Eduardo Agustin Padlan
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Eduardo Agustin Padlanbiology Degrees
Biology
#12865
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#16369
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Immunology
#867
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#890
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Biochemistry
#2224
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#2370
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Biology
Eduardo Agustin Padlan's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Biochemistry University of California, Berkeley
- Bachelors Chemistry University of the Philippines
Why Is Eduardo Agustin Padlan Influential?
(Suggest an Edit or Addition)Eduardo Agustin Padlan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Conformations of immunoglobulin hypervariable regions (1989) (1112)
- Anatomy of the antibody molecule. (1994) (877)
- Antibody-antigen complexes. (1988) (636)
- Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium. (1988) (599)
- Three-dimensional structure of an antibody-antigen complex. (1987) (536)
- Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. (1985) (513)
- Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex. (1989) (417)
- The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. (1974) (402)
- Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action. (1987) (270)
- On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands (1990) (223)
- Three-dimensional structure of immunoglobulins. (1975) (208)
- The B-cell binding site on human immunoglobulin E (1988) (207)
- A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties. (1991) (172)
- Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis. (1987) (166)
- X-ray crystallography of antibodies. (1996) (156)
- Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex (1992) (151)
- Identification of specificity‐determining residues in antibodies (1995) (134)
- Three-dimensional structure of hemoglobin from the polychaete annelid, Glycera dibranchiata, at 2.5 A resolution. (1974) (119)
- Structural basis for the specificity of phosphorylcholine-binding immunoglobulins. (1976) (110)
- Refined crystal structure of deoxyhemoglobin S. II. Molecular interactions in the crystal. (1985) (107)
- Structure at 4.5 A resolution of a phosphorylcholine-binding fab. (1973) (104)
- H-2Dd exploits a four residue peptide binding motif (1993) (93)
- Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49. (1995) (88)
- Refined crystal structure of deoxyhemoglobin S. I. Restrained least-squares refinement at 3.0-A resolution. (1982) (88)
- Structural basis for the specificity of antibody–antigen reactions and structural mechanisms for the diversification of antigen-binding specificities (1977) (82)
- A humanized form of a CD4-specific monoclonal antibody exhibits decreased antigenicity and prolonged plasma half-life in rhesus monkeys while retaining its unique biological and antiviral properties. (1997) (74)
- Model-building studies of antigen-binding sites: the hapten-binding site of mopc-315. (1977) (73)
- The structural and genetic basis for expression of normal and latent VHa allotypes of the rabbit. (1984) (69)
- The mast cell binding site on human immunoglobulin E (1988) (60)
- Antibody-antigen complexes. (1988) (57)
- Structural Correlates of an Anticarcinoma Antibody: Identification of Specificity-Determining Residues (SDRs) and Development of a Minimally Immunogenic Antibody Variant by Retention of SDRs Only (2000) (57)
- On the specificity of antibody/antigen interactions: phosphocholine binding to McPC603 and the correlation of three-dimensional structure and sequence data. (1985) (56)
- Crystals of phosphorylcholine-binding Fab-fragments from mouse myeloma proteins: preparation and x-ray analysis. (1972) (55)
- Structure‐function analysis of a lupus anti‐DNA autoantibody: central role of the heavy chain complementarity‐determining region 3 Arg in binding of double‐ and single‐stranded DNA (2000) (54)
- Structure of the Haemoglobin of the Marine Annelid Worm, Glycera dibranchiata, at 5.5 Å Resolution (1968) (53)
- Variability of three-dimensional structure in immunoglobulins. (1975) (52)
- Water molecules in the antibody-antigen interface of the structure of the Fab HyHEL-5-lysozyme complex at 1.7 A resolution: comparison with results from isothermal titration calorimetry. (2005) (49)
- Model-building study of the combining sites of two antibodies to alpha (1----6)dextran. (1988) (48)
- A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough (2015) (47)
- A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation. (2001) (46)
- Why is there a greater incidence of allergy to the tropomyosin of certain animals than to that of others? (2007) (45)
- Analysis of the structure of naturally processed peptides bound by class I and class II major histocompatibility complex molecules. (1995) (44)
- Structural implications of sequence variability in immunoglobulins. (1977) (44)
- SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity. (2004) (43)
- A monoclonal anti-IgE antibody against an epitope (amino acids 367-376) in the CH3 domain inhibits IgE binding to the low affinity IgE receptor (CD23). (1988) (42)
- Amino acid residues that influence Fc epsilon RI-mediated effector functions of human immunoglobulin E. (1998) (42)
- Analysis of the antibody structure based on high-resolution crystallographic studies. (2011) (39)
- A model of the Fc of immunoglobulin E. (1985) (39)
- BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties. (2011) (39)
- Kappa chain structure from a crystallized murine Fab': role of joining segment in hapten binding. (1981) (38)
- Identification of the High Affinity Receptor Binding Region in Human Immunoglobulin E (*) (1996) (37)
- Immunoglobulin structures at high resolution. (1975) (36)
- Grafting of “Abbreviated” Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody (2002) (36)
- Glycera dibranchiata Hemoglobin (1989) (35)
- Peptide blocking of IgE/receptor interaction: possibilities and pitfalls (1997) (35)
- CDR substitutions of a humanized monoclonal antibody (CC49): contributions of individual CDRs to antigen binding and immunogenicity. (1999) (34)
- Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. (1994) (33)
- The nature and importance of the inter‐ε chain disulfide bonds in human IgE (1991) (32)
- The structures of lamprey and bloodworm hemoglobins in relation to their evolution and function. (1972) (32)
- Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies (2010) (32)
- Crystal structure of galactan-binding mouse immunoglobulin J539 Fab at 4.5-A resolution. (1979) (31)
- Structural Studies of Human Autoantibodies (1996) (30)
- Twisting into shape (1992) (30)
- Antibody Fab assembly: the interface residues between CH1 and CL. (1986) (29)
- Modeling of antibody combining sites. (1991) (29)
- Structures of complexes of rhizopuspepsin with pepstatin and other statine‐containing inhibitors (1991) (25)
- Binding characteristics of IgA 16.4.12E, a monoclonal antibody with specificity for the nonreducing terminal epitope of alpha-(1----6)-dextrans. Comparisons between IgA hybridoma 16.4.12E and myeloma W3129. (1990) (25)
- In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and characterization of minimally immunogenic high-affinity variants. (2003) (24)
- Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues. (2003) (22)
- The pandemic 2009 (H1N1) swine influenza virus is mild compared to the pandemic 1918 (H1N1) virus because of a proline-to-serine substitution in the receptor-binding site of its hemagglutinin - a hypothesis. (2010) (21)
- A humanized antibody with specificity for hepatitis B surface antigen. (1996) (20)
- Crystalline monoclonal antibody Fabs complexed to hen egg white lysozyme. (1984) (19)
- Humanization of Monoclonal Antibodies (1994) (18)
- Development of a minimally immunogenic variant of humanized anti-carcinoma monoclonal antibody CC49. (2001) (17)
- A study of the structural correlates of affinity maturation: antibody affinity as a function of chemical interactions, structural plasticity and stability. (2007) (17)
- Generation and characterization of a single gene-encoded single-chain-tetravalent antitumor antibody. (1999) (16)
- A T cell receptor V alpha domain expressed in bacteria: does it dimerize in solution? (1996) (16)
- Generation and characterization of a novel single-gene-encoded single-chain immunoglobulin molecule with antigen binding activity and effector functions. (1999) (16)
- Quantitation of the immunogenic potential of protein antigens. (1985) (15)
- Evolutionary and structural influences on light chain constant (CL) region of human and mouse immunoglobulins. (1975) (15)
- Localized deletion-insertion mutations: a major factor in the evolution of immunoglobulin structural variability. (1976) (15)
- The X-ray crystal structure of a Valpha2.6Jalpha38 mouse T cell receptor domain at 2.5 A resolution: alternate modes of dimerization and crystal packing. (1999) (15)
- Molecular-replacement structure determination of two different antibody:antigen complexes. (1990) (15)
- Structure–function studies of an anti-asialo GM1 antibody obtained from a phage display library (1999) (14)
- Humanization of KC4G3, an anti-human carcinoma antibody. (1994) (14)
- A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E. (1995) (13)
- Binding of modified fragments of the Shigella dysenteriae type 1 O-specific polysaccharide to monoclonal IgM 3707 E9 and docking of the immunodeterminant to its modeled Fv. (1998) (13)
- Structural significance of sequence variability in antibody complementarity-determining regions. (1994) (13)
- A crystallographic study of deoxy cobalt (II) mesoporphyrin IX myoglobin. (1975) (12)
- Comparative study of two Fab-lysozyme crystal structures. (1989) (12)
- Glycera dibranchiata hemoglobin. X-ray structure of carbonmonoxide hemoglobin at 1.5 A resolution. (1994) (12)
- Engineering of antibodies for breast cancer therapy: construction of chimeric and humanized versions of the murine monoclonal antibody BrE-3. (1994) (12)
- Modelling study of IgE/receptor interactions. (1993) (11)
- Evaluation of the structural variation among light chain variable domains. (1979) (11)
- Structure-function studies of anti-3-fucosyllactosamine (Le(x)) and galactosylgloboside antibodies. (1994) (11)
- THE THREE-DIMENSIONAL STRUCTURE OF THE ANTIGEN BINDING SITE OF McPC 603 PROTEIN (1974) (10)
- Why don't humans get scrapie from eating sheep? A possible explanation based on secondary structure predictions. (2005) (9)
- Structural and genetic basis of idiotypy in the galactan-binding myeloma proteins. (1979) (9)
- Novel humanized anti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions. (1992) (9)
- Structure/function studies on IgE as a basis for the development of rational IgE (1998) (9)
- Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation? (1997) (9)
- T-cell receptors: Feeling out the complex (1997) (8)
- Are humans getting 'mad-cow disease' from eating beef, or something else? (2003) (7)
- The codon for the methionine at position 129 (M129) in the human prion protein provides an alternative initiation site for translation and renders individuals homozygous for M129 more susceptible to prion disease. (2005) (5)
- Protein and cell engineering of components of the human immunoglobulin E receptor/effector system: applications for therapy and diagnosis. (1998) (5)
- Development of more efficacious antibodies for medical therapy and diagnosis. (1998) (5)
- Localization of rabbit kappa light chain allotypic determinants. (1986) (5)
- Selected essays on science and technology for securing a better Philippines (2008) (5)
- An em study of phosphorylcholine-binding fab immunoglobulin fragment crystals. (1975) (5)
- Two Ig framework I epitopic specificities recognized by a rabbit antiserum and a monoclonal antibody to mouse VH chains. (1990) (4)
- A Novel Method for Designing Vaccines Against Constantly Mutating Pathogens (2008) (3)
- A method for designing molecules for use in directing the antibody response to a chosen region of a protein antigen (2010) (3)
- Crystalline semisynthetic ribonuclease-S'. (1976) (3)
- REFINED CRYSTAL STRUCTURE OF THE MC/PC603 FAB-PHOSPHOCHOLINE COMPLEX AT 3.1 ANGSTROMS RESOLUTION (1985) (3)
- Crystallographic studies and primary structure of the antitumor monoclonal CC49 Fab′ (1993) (3)
- Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23). (1993) (2)
- Do prions aggregate in response to electrical stimulation and does this play a role in long-term memory? (2009) (2)
- Effects of engineering charged amino acids in the C H 3 domains on antibody heavy chain dimerization (2011) (2)
- Commerce versus collaboration (1991) (2)
- Structure/function studies on IgE as a basis for the development of rational IgE antagonists. (1998) (2)
- Anatomy of the antibody molecule : a continuing analysis based on high-resolution crystallographic structures (2012) (1)
- MODEL-BUILDING STUDY OF THE COMBINING SITES OF TWO ANTIBODIES TO ALPHA(1(RIGHT ARROW)6)DEXTRAN (1989) (1)
- Can we find a possible structural explanation for antibody-dependent enhancement of dengue virus infection resulting in hemorrhagic fever? (2016) (1)
- Philippine Science Letters - now on its second year (2009) (1)
- Does mRNA translation starting from an alternative initiation site contribute to the pathology of Huntington's disease? (2000) (1)
- REFINED CRYSTAL STRUCTURE OF THE GALACTAN-BINDING IMMUNOGLOBULIN FAB J539 AT 1.95-ANGSTROMS RESOLUTION (1990) (1)
- MODELING OF THE LECTIN-HOMOLOGY DOMAINS OF THE HUMAN AND MURINE LOW-AFFINITY FCE RECEPTOR (FCERII(SLASH)CD23) (1994) (1)
- Derivation of Therapeutically Active Humanized and Veneered Anti-CD18 Antibodies (1994) (1)
- Does the electrical activity of neurons contribute to the pathogenesis of Alzheimer's Disease? (2010) (1)
- Fab Assembly: An Analysis of Different CH1: CL Combinations (1986) (1)
- Expressed in Bacteria : Does It D imer ize in Solution ? (1996) (0)
- Peptides with broad specificity of neoplastic (1993) (0)
- TR1.9 FAB FRAGMENT OF A HUMAN IGG1 KAPPA AUTOANTIBODY (1996) (0)
- V-ALPHA 2.6 MOUSE T CELL RECEPTOR (TCR) DOMAIN (1999) (0)
- Protein and cell engineering of components of the human receptor/effector system : applications for therapy and diagnosis (1998) (0)
- Variability of Three-Dimensional Structure in Immunoglobulins ( three-dimensional structure comparisons / structure-sequence homology / diagonal plots / antibody diversity / evolutionary relationships ) (0)
- The Three Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site ( x-ray diffraction / domain structure / hypervariable cavity / hapten binding / antibody diversity ) (0)
- Proud of our science – and our scientists (2008) (0)
- Three-dimensional structure of an antibody-antigen complex ( immunoglobulins / epitope / x-ray crystallography / complementarity / lysozyme ) (2003) (0)
- Humanized col-1 antibody with substituted residues at the skeleton, and their application (2005) (0)
- MODELING OF THE LECTIN-HOMOLOGY DOMAINS OF THE HUMAN AND MURINE FCE RECEPTOR (FCERII(SLASH)CD23) (1994) (0)
- Comparative Structures of Mouse Antibody Combining Sites (1985) (0)
- Myeloma proteins, preparation and x-ray analysis. (1972) (0)
- Can we explain the allergenicity of peanuts on the basis of the three-dimensional structure of its allergens and use the information to devise means of eliminating peanut allergy? (2012) (0)
- Peptides et peptides anti-sens a large specificite neoplasique (1993) (0)
- COMMERCE VERSUS COLLABORATION. REPLY (1991) (0)
- Design of possibly useful vaccines against human immunodeficiency virus 1 (2012) (0)
- 15 – Comparative Structures of Two Lysozyme–Antilysozyme Complexes (1990) (0)
- SHORT COMMUNICATION: On Scientific Publications (2007) (0)
- The crystal structure of the antibody Fab HyHEL5 complex with lysozyme at 1.7A resolution (2005) (0)
- Protein engineering from plants to animals, from big to small, from outside to inside and other advances. (1997) (0)
- Crystal structure of galactan-binding mouse immunoglobulin J 539 Fab at 4 . 5-A resolution ( x-ray diffraction / pattern recognition / antibody structure ) (0)
- Can we use DNA triple helices as treatment for systemic lupus erythematosus? (2014) (0)
- Structural implications of sequence variability in immunoglobulins ( dissimilarities between amino acids / conservative and nonconservative replacements / specificity-determining residues ) (0)
- Anticorps monoclonal anti-cd-20 (2006) (0)
- Antibody Variant by Retention of SDRs Only Development of a Minimally Immunogenic Specificity-Determining Residues (SDRs) and Antibody: Identification of Structural Correlates of an Anticarcinoma (2000) (0)
- Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses (2023) (0)
- Humanized antibodies against humanes gp39, compositions containing them and their therapeutic uses (1996) (0)
- Synthetic Saccharides Can Delineate the Binding of Polysaccharide to Monoclonal Antibodies. (1995) (0)
- Structure of a phosphorycholine-binding mouse myeloma Fab. (1975) (0)
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What Schools Are Affiliated With Eduardo Agustin Padlan?
Eduardo Agustin Padlan is affiliated with the following schools:
