Elizabeth C. Leroy
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Elizabeth C. Leroymedical Degrees
Medical
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Rheumatology
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Why Is Elizabeth C. Leroy Influential?
(Suggest an Edit or Addition)Elizabeth C. Leroy's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. (1988) (3914)
- Criteria for the classification of early systemic sclerosis. (2001) (1319)
- Natural History of Asymptomatic Left Ventricular Systolic Dysfunction in the Community (2003) (562)
- A disease severity scale for systemic sclerosis: development and testing. (1999) (436)
- Pathogenesis of systemic sclerosis: a vascular hypothesis. (1975) (399)
- Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. (1974) (386)
- Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. (1980) (365)
- TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression (1987) (333)
- THE RELATIONSHIP OF HYPERTENSION AND RENAL FAILURE IN SCLERODERMA (PROGRESSIVE SYSTEMIC SCLEROSIS) TO STRUCTURAL AND FUNCTIONAL ABNORMALITIES OF THE RENAL CORTICAL CIRCULATION (1974) (320)
- Patterns of finger capillary abnormalities in connective tissue disease by "wide-field" microscopy. (1973) (309)
- Endothelial injury in scleroderma (1979) (280)
- Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. (1980) (272)
- Systemic sclerosis. A vascular perspective. (1996) (265)
- Raynaud's phenomenon: a proposal for classification. (1992) (243)
- Activation of Hageman factor by collagen. (1968) (216)
- Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. (1981) (214)
- A STRATEGY FOR DETERMINING THE PATHOGENESIS OF SYSTEMIC SCLEROSIS: Is Transforming Growth Factor β the Answer? (1989) (201)
- Microvascular abnormalities as possible predictors of disease subsets in Raynaud phenomenon and early connective tissue disease. (1983) (198)
- CONNECTIVE TISSUE SYNTHESIS BY SCLERODERMA SKIN FIBROBLASTS IN CELL CULTURE (1972) (190)
- Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts (1992) (179)
- Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis. (1976) (177)
- Undifferentiated connective tissue syndromes. (1980) (176)
- Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. (1995) (170)
- Prevalence of scleroderma spectrum disorders in the general population of South Carolina. (1989) (166)
- Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis. (1996) (163)
- Aggregation of platelets by collagen. (1968) (157)
- A prospective study of Raynaud phenomenon and early connective tissue disease. A five-year report. (1982) (151)
- Transcriptional regulation of the human alpha2(I) collagen gene. Combined action of upstream stimulatory and inhibitory cis-acting elements. (1996) (150)
- Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site* (1997) (149)
- Fibroblast selection in scleroderma (1982) (146)
- Elevated levels of circulating platelet aggregates and beta-thromboglobulin in scleroderma. (1982) (131)
- Characterization of a GC-rich Region Containing Sp1 Binding Site(s) as a Constitutive Responsive Element of the α2(I) Collagen Gene in Human Fibroblasts (*) (1995) (127)
- Interleukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration. (1989) (125)
- Guidelines for clinical trials in systemic sclerosis (scleroderma). I. Disease-modifying interventions. The American College of Rheumatology Committee on Design and Outcomes in Clinical Trials in Systemic Sclerosis. (1995) (120)
- Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor. (1994) (118)
- Pericardial disease in scleroderma (systemic sclerosis). (1974) (117)
- Prevalence of Raynaud phenomenon in the general population. A preliminary study by questionnaire. (1986) (110)
- Human cytomegalovirus and the vasculopathies of autoimmune diseases (especially scleroderma), allograft rejection, and coronary restenosis. (1998) (109)
- A HYDROXYPROLINE-CONTAINING, COLLAGEN-LIKE PROTEIN IN PLASMA AND A PROCEDURE FOR ITS ASSAY. (1964) (105)
- IL-4 upregulates tenascin synthesis in scleroderma and healthy skin fibroblasts. (1996) (100)
- Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation. (1992) (94)
- Mitogenic effect of transforming growth factor β1 on human fibroblasts involves the induction of platelet‐derived growth factor α receptors (1990) (92)
- A modified scleroderma skin scoring method. (1986) (89)
- Interstitial lung disease in scleroderma. Analysis by bronchoalveolar lavage. (1984) (88)
- Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents. (1984) (84)
- Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) Study. (2011) (84)
- A brief overview of the pathogenesis of scleroderma (systemic sclerosis). (1992) (81)
- Antibodies to collagen in scleroderma. (1982) (76)
- Importances of Polar Groups for initiating Blood Coagulation and aggregating Platelets (1969) (74)
- Skin capillary blood flow in scleroderma. (1971) (69)
- The management of renal scleroderma: experience with dialysis, nephrectomy and transplantation. (1978) (69)
- Autoimmunity and vascular involvement in systemic sclerosis (SSc). (1999) (66)
- Variable response to oral angiotensin-converting-enzyme blockade in hypertensive scleroderma patients. (1982) (66)
- Serum DNA binding activity in healthy subjects and in rheumatic disease. (1974) (65)
- Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma. (1992) (65)
- Hydroxyproline and Collagen Metabolism: Clinical Implications: Combined Clinical Staff Conference at the National Institutes of Health (1965) (64)
- The role of infectious agents in the pathogenesis of systemic sclerosis (2002) (64)
- Macroscopic Studies of Platelet Agglutination; Nature of Thrombocyte Agglutinating Activity of Plasma.∗ (1958) (62)
- Mast Cells and Their Degranulation in the Tsk Mouse Model of Scleroderma (1985) (62)
- Nucleographic studies of axial spondarthritides. I. Quantitative sacroiliac scintigraphy in early HLA-B27-associated sacroiliitis. (1977) (62)
- Fibroblast selection in scleroderma. An alternative model of fibrosis. (1982) (60)
- Primary heart disease in systemic sclerosis (scleroderma): advances in clinical and pathologic features, pathogenesis, and new therapeutic approaches. (1981) (59)
- The coincidence of Klinefelter's syndrome and systemic lupus erythematosus. (1969) (58)
- Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon. (1982) (57)
- Inhibition of fibrosis in TSK mice by blocking mast cell degranulation. (1987) (57)
- Human monocyte stimulation of fibroblast growth by a soluble mediator(s). (1980) (57)
- Cytokines and human fibrosis. (1990) (54)
- Effect of lymphotoxin and tumor necrosis factor on endothelial and connective tissue cell growth and function. (1988) (54)
- Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors. (1982) (52)
- Cellular immunity to collagen and laminin in scleroderma. (1985) (52)
- CLINICAL SIGNIFICANCE OF A HYDROXYPROLINE-CONTAINING PROTEIN IN HUMAN PLASMA. (1965) (51)
- Scleroderma and related conditions. (1997) (50)
- The Technique and Significance of Hydroxyproline Measurement in Man (1967) (49)
- Spontaneous production of fibronectin by alveolar macrophages in patients with scleroderma. (1989) (49)
- Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. (2010) (49)
- Evidence of activation of 2 herpesviruses, Epstein-Barr virus and cytomegalovirus, in systemic sclerosis and normal skins. (2000) (48)
- Consensus statement on the relationship of breast implants to connective-tissue disorders. (1992) (48)
- Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts. (1988) (48)
- The pathogenesis of scleroderma (systemic sclerosis, SSc). (1991) (48)
- Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts. (1994) (47)
- A Possible Role for Transforming Growth Factor-β in Systemic Sclerosis (1990) (45)
- The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. (1995) (45)
- Fibronectin release by systemic sclerosis and normal dermal fibroblasts in response to TGF-beta. (1991) (45)
- SEXUAL FUNCTION AND ERECTION CAPABILITY AMONG YOUNG MEN WITH SPINA BIFIDA (1996) (43)
- The connective tissue in scleroderma. (1981) (42)
- Collagen-Like Protein in Human Plasma (1963) (42)
- Pathogenesis of scleroderma (systemic sclerosis). (1982) (41)
- Fasciitis (not scleroderma) following prolonged exposure to an organic solvent (trichloroethylene). (1994) (41)
- Basic fibroblast growth factor inhibits basal and transforming growth factor-beta induced collagen alpha 2(I) gene expression in scleroderma and normal fibroblasts. (1997) (41)
- Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy. (1976) (41)
- Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry. (2010) (40)
- Ketotifen prevents skin fibrosis in the tight skin mouse. (1990) (40)
- Eosinophil adhesion and maturation is modulated by laminin. (1993) (39)
- Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig. (1997) (38)
- Persistent effect of TGF-beta 1 on extracellular matrix gene expression in human dermal fibroblasts. (1990) (38)
- Transforming growth factor-beta 1 and collagen gene expression during postnatal skin development and fibrosis in the tight-skin mouse. (1995) (38)
- Familial clustering of scleroderma spectrum disease. (1988) (37)
- Different effects of basic fibroblast growth factor and transforming growth factor-beta on the two platelet-derived growth factor receptors' expression in scleroderma and healthy human dermal fibroblasts. (1995) (36)
- MCMV induces neointima in IFN-γR-/- mice: Intimal cell apoptosis and persistent proliferation of myofibroblasts (2001) (36)
- Pulmonary hypertension in interstitial lung disease: relation of vascular resistance to abnormal lung structure. (1975) (36)
- Adoptive Transfer of tsk Skin Fibrosis to +/+ Recipients by tsk Bone Marrow and Spleen Cells (1989) (35)
- Standstill of nailfold capillary blood flow during cooling in scleroderma and Raynaud's syndrome. (1976) (35)
- Blood viscosity, plasma proteins, and Raynaud syndrome. (1975) (34)
- Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites (2010) (34)
- Major clinical diagnoses found among patients with Raynaud phenomenon from the general population. (1990) (34)
- Cytokines and systemic sclerosis. (1994) (34)
- Surface binding, internalization and degradation by cultured human fibroblasts of low density lipoproteins isolated from Type 1 (insulin-dependent) diabetic patients: Changes with metabolic control (1982) (32)
- Chromosome breakage and sister chromatid exchange frequencies in scleroderma. (1981) (31)
- Collagen synthesis in the developing chick heart. (1979) (30)
- A possible role for transforming growth factor-beta in systemic sclerosis. (1990) (30)
- Interstitial lung disease in scleroderma. Immune complexes in sera and bronchoalveolar lavage fluid. (1986) (29)
- Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's phenomenon from a single kindred. (1981) (29)
- Immune response to connective tissue components of the basement membrane. (1982) (25)
- Human monocyte modulation of endothelial cells and fibroblast growth: possible mechanism for fibrosis. (1986) (25)
- Anti-Fibrillin-1 Autoantibodies in Systemic Sclerosis Are GM and KM Allotype-Restricted (2001) (25)
- Dipyridamole Decreases Platelet‐Derived Growth Factor Levels in Human Serum (1987) (24)
- The heart in systemic sclerosis. (1984) (21)
- Differential responses of human papillary and reticular fibroblasts to growth factors. (1993) (20)
- Precursor-size components are the basic collagenous subunits of murine tumor basement membrane. (1982) (20)
- Association of fibrinogen and microfibrils with trophoblast basement membrane. (1975) (18)
- A modified procedure for radioactive hydroxyproline assay in urine and tissues after labeled proline administration. (1966) (18)
- Characterization of the release of human monocyte regulators of fibroblast proliferation. (1982) (18)
- Human alveolar basement membrane. Chemical and immunologic comparisons with glomerular basement membrane and trophoblast basement membrane. (1976) (18)
- Raynaud's phenomenon of a single digit following local intradermal bleomycin sulfate injection. (1985) (17)
- Gonococcal arthritis in two patients with active lupus erythematosus. A diagnostic problem. (1971) (16)
- Thermoregulation and Raynaud's phenomenon. (1971) (16)
- Elevated plasma levels of a hydroxyproline-containing protein in Hodgkin's disease and their relation to disease activity. (1966) (16)
- Endothelial injury in scleroderma. A protease mechanism. (1983) (16)
- Cultivation of microvascular endothelial cells from human preputial skin (1980) (15)
- The 72-kilodalton IE-1 protein of human cytomegalovirus (HCMV) is a potent inducer of connective tissue growth factor (CTGF) in human dermal fibroblasts. (2004) (15)
- Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts. (1992) (14)
- Delayed-type hypersensitivity to elastase-soluble lung peptides in the tight-skin (Tsk) mouse. (1983) (13)
- In vivo observations of skin capillaries in workers exposed to vinyl chloride. An English-American comparison. (1978) (13)
- Cell-mediated immunity to homologous basement membrane (type IV) collagen in C57BL6 mice (1981) (13)
- Sentinel signs and symptoms of systemic sclerosis. (1990) (13)
- Ascorbate effects on type I procollagen synthesis by human adult skin fibroblasts: different migration positions of type I procollagen chains on SDS polyacrylamide gel after incubation with ascorbate. (1987) (13)
- Raynaud's phenomenon and scleroderma. (1981) (13)
- Human Monocyte Regulation of Connective Tissue Growth (1983) (12)
- Mitogenic effect of transforming growth factor beta 1 on human fibroblasts involves the induction of platelet-derived growth factor alpha receptors. (1990) (12)
- Genes in the insulin and insulin-like growth factor pathway and odds of metachronous colorectal neoplasia (2011) (12)
- Studies in patients with connective tissue disorders. (1977) (11)
- Enhanced platelet adhesion to collagen in scleroderma. Effect of scleroderma plasma and scleroderma platelets. (1985) (11)
- Species differences in platelet agglutination in man and in the dog, swine and rabbit. (1960) (11)
- Immune Response to Laminin, a Noncollagenous Glycoprotein of Basement Membrane, in a Syngeneic Murine System 1 (1982) (10)
- Differential Modulation of bFGF Receptors by TGF‐β in Adult Skin, Scleroderma Skin, and Newborn Foreskin Fibroblasts (1992) (10)
- Sexual knowledge and experience among young men with spina bifida. (1994) (10)
- Systemic vasculitis : the biological basis (1992) (10)
- Variations in plasma levels of a hydroxyproline-containing protein with fever and inflammation in man (1966) (8)
- Nailfold biopsy in scleroderma and related disorders. Correlation of histologic, capillaroscopic, and clinical data. (1984) (8)
- Abnormal capillary patterns and systemic disease in scleroderma (progressive systemic sclerosis). (1975) (7)
- Dot-like focal contacts in adherent eosinophils, their redistribution into peripheral belts, and correlated effects on cell migration and protected zone formation. (1996) (7)
- Cation Specificity of Thrombocyte Agglutinating Activity (TAg) of Canine Plasma.∗ (1959) (7)
- Scleroderma (Systemic Sclerosis) and Morphea (1998) (7)
- Overlap features of connective tissue disease. (1982) (7)
- Capillary blood flow in scleroderma. (1973) (6)
- Fibroblast heterogeneity in scleroderma: Clq studies. (1987) (6)
- DNA binding activity of serum from patients with systemic lupus erythematosus. (1979) (6)
- Thrombospondin 1 is Expressed by Mesenchymal Cells in Mouse Post-natal Skin and Hair Follicle Development (1998) (6)
- The changing face of severe scleroderma in five patients. (1990) (6)
- Transcriptional Regulation of the Human α2(I) Collagen Gene (1996) (6)
- The vascular defect in scleroderma (systemic sclerosis). (2009) (5)
- A fibroblast mitogen present in scleroderma but not control sera: Inhibition by proteinase inhibitors (2004) (5)
- Selective Upregulation of Platelet-derived Growth Factor c ~ Receptors by Transforming Growth Factor / ~ in Scleroder Fibroblasts (2003) (5)
- The spectrum of scleroderma (II). (1989) (5)
- The spectrum of scleroderma. (1989) (5)
- Collagen deposition in autoimmune diseases: the expanding role of the fibroblast in human fibrotic disease. (1985) (5)
- The acute phase response in scleroderma. Differing responses to intravenous PGE1. (1986) (4)
- The tight-skin (Tsk) mutation is closely linked to B2m on mouse Chromosome 2 (2004) (4)
- Cell-mediated immunity to homologous basement membrane (type IV) collagen in C57BL/6 mice. (1981) (4)
- Paul Klee and scleroderma. (1996) (4)
- Raynaud phenomenon. (1986) (4)
- Pulmonary hypertension: the bête noire of the diffuse connective tissue diseases. (1991) (3)
- A profibrotic polymorphism (of TGFβ1) in systemic sclerosis (2002) (3)
- Effect of scleroderma serum on human fibroblast collagen production: possible selection through proliferation. (1986) (2)
- Collagen in the physiology and pathology of connective tissue. Steffan Gay and Edward J. Miller. New York, Gustav Fischer Inc., 1978. 106 pages; illustrated. price: $21.10. (1980) (2)
- Correlation of capillary morphology and flow during cold exposure in Raynaud syndrome. (1979) (2)
- Lupus and its management. (1993) (2)
- Human Leukocyte Antigens (HLA) (1978) (2)
- Some characteristics of the antigenic moiety of calfskin collagen. (1969) (2)
- Scientific workshop on the biology and pathology of acquired connective tissue diseases. (1992) (2)
- The immunopathogenesis of systemic sclerosis. Introduction. (1995) (1)
- Proceedings: Connective tissue proteins synthesized by scleroderma fibroblasts in cell culture. (1975) (1)
- Hydroxyproline and Collagen Metabolism (2020) (1)
- Collagens and human disease. (1974) (1)
- Precipitating and Complement-Fixing Antibodies to Collagen with Species and Collagen Subunit Specificity∗ (1968) (1)
- Breast augmentation--is there a risk? (1990) (1)
- Cross-reactivity of cell-mediated immunity between interstitial (type I) and basement membrane (type IV) collagens (1982) (1)
- Systemic sclerosis (scleroderma): Current topics in rheumatology. C. M. Black and A. R. Myers (editors). New York, Gower Medical Publishing, 1985, 459 pages. $50.00 (1986) (1)
- Raynaud's phenomenon, scleroderma, overlap syndromes, and other fibrosing syndromes. (1992) (1)
- Biology of platelet-derived growth factor Edited by B. Westermark and C. Sorg. (Cytokines, volume 5, edited by C. Sorg). Basel, Karger, 1993, $196.00, SFr. 245.-, DM 293,-, f106.60 (viii + 168 pages), ISBN 3-805-55635-7 (1993) (0)
- Transitions in generalized scleroderma. (1989) (0)
- Mechanisms of tissue injury with reference to Rheumatoid Arthritis: Edited by R. J. Perper. Annals of the New York Academy of Sciences256, 1–450, 1975 (1977) (0)
- A dialogue for the management of common musculoskeletal disorders. (1993) (0)
- Raynaud's phenomenon and connective tissue diseases. (1993) (0)
- In Vivo Skin Capillary Abnormalities in Vinyl Chloride Workers (1976) (0)
- [Study of a protein anabolic agent in pediatrics. Apropos of 2 clinical trials]. (1963) (0)
- Scleroderma as a Fibrotic Disorder (1985) (0)
- Basic FGF inhibits collagen α2(I) gene expression in scleroderma and normal fibroblasts (1994) (0)
- Scleroderma: A Review of Vascular Features (1995) (0)
- In appreciation fo j. claude bennet, m.d. editor, 1975–1980 (1980) (0)
- The 1968 interim scientific session of the American Rheumatism Association. (1969) (0)
- The pathogenesis of systemic sclerosis. (1989) (0)
- Abstract 2853: Genetic variation in IGF1, GHR, and IGFBP1 is associated with colorectal cancer (2010) (0)
- The 1969 Interim Meeting of the American Rheumatism Association. (1970) (0)
- Genetic Variation in IGF1, GHR, and IGFBP1 is Associated with Colorectal Cancer (2010) (0)
- Proceedings: Changes in blood viscosity and plasma proteins with Raynaud's phenomenon. (1976) (0)
- The year book of rheumatology (1994) (0)
- The systemic vasculitides. (1992) (0)
- Therapy for connective tissue disease. (1986) (0)
- Transcriptional regulation of human collagen α2(I) promoter in human fibroblasts (1994) (0)
- Association Between Polymorphic Variation in GC and Circulating Levels of Vitamin D Metabolites (2010) (0)
- Passing of an American College of Rheumatology collaborator and friend (1997) (0)
- 16 – PROTEINASES IN THE FIBROSIS OF SYSTEMIC SCLEROSIS (1989) (0)
- Sentinel signs and symptoms of systemic sclerosis. (1989) (0)
- Raynaud's phenomenon, scleroderma, overlap syndromes, and other fibrosing syndromes Editorial overview (1992) (0)
- Morbidity and mortality of rheumatic and diffuse connective tissue diseases. (1989) (0)
- The t ight-skin ( Tsk ) mutat ion is closely l inked to B 2 m on mouse Chromosome 2 (0)
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