E. J. Jr. Merck Sharp Cragoe

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Chemistry

E. J. Jr. Merck Sharp Cragoe's Degrees

PhD Chemistry University of California, Berkeley

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E. J. Jr. Merck Sharp Cragoe's Published Works

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Published Works

Amiloride and its analogs as tools in the study of ion transport (1988) (524)
Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series. (1984) (272)
Control of intracellular pH and growth by fibronectin in capillary endothelial cells (1990) (240)
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. (1990) (239)
Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways. (1987) (206)
NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na(+)-H+ exchange. (1993) (194)
Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system. (1984) (184)
Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride. (1984) (173)
Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange. (1985) (173)
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3. (1992) (168)
Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. (1987) (166)
Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets. (1986) (159)
Demonstration of a [K+,Cl-]-cotransport system in human red cells by its sensitivity to [(dihydroindenyl)oxy]alkanoic acids: regulation of cell swelling and distinction from the bumetanide-sensitive [Na+,K+,Cl-]-cotransport system. (1988) (158)
Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types. (1983) (146)
Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+/H+ exchanger. (1991) (144)
Regulation of human neutrophil chemotaxis by intracellular pH. (1986) (142)
Epithelial chloride channel. Development of inhibitory ligands (1987) (138)
Inhibition of Na+/Ca2+ exchange in pituitary plasma membrane vesicles by analogues of amiloride. (1985) (133)
Intracellular pH regulation in resting and contracting segments of rat mesenteric resistance vessels. (1988) (131)
Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. (1989) (129)
Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step. (1986) (126)
Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs. (1986) (125)
Inhibition of Na+/Ca2+ exchange enhances delayed neuronal death elicited by glutamate in cerebellar granule cell cultures (1991) (124)
Characterization of potent Na+/H+ exchange inhibitors from the amiloride series in A431 cells. (1984) (121)
Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin. (1985) (120)
Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform. (1993) (120)
Relations among sodium pump inhibition, Na-Ca and Na-H exchange activities, and Ca-H interaction in cultured chick heart cells. (1987) (119)
Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways. (1990) (116)
Inhibition of chemotactic factor-activated Na+/H+ exchange in human neutrophils by analogues of amiloride: structure-activity relationships in the amiloride series. (1986) (111)
Cation transport probes: the amiloride series. (1990) (107)
Ethylisopropylamiloride-sensitive pH control mechanisms modulate vascular smooth muscle cell growth. (1991) (100)
Effects of proton buffering and of amiloride derivatives on reperfusion arrhythmias in isolated rat hearts. Possible evidence for an arrhythmogenic role of Na(+)-H+ exchange. (1990) (98)
Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs. (1990) (98)
Chemical modification of cell proliferation and fluid secretion in renal cysts. (1989) (96)
Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation. (1985) (91)
Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive. (1987) (86)
Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange. (1987) (86)
Thrombin-stimulated events in cultured vascular smooth-muscle cells. (1991) (85)
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. (1988) (85)
Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium (1989) (84)
Activation of the Na+/H+ and Cl-/HCO3- exchange by stimulation of acid secretion in the parietal cell. (1988) (82)
Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol (1990) (82)
Na-H exchange is a major pathway for Na influx in rat vascular smooth muscle. (1986) (81)
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy. (1993) (77)
Intracellular pH in human arterial smooth muscle. Regulation by Na+/H+ exchange and a novel 5-(N-ethyl-N-isopropyl)amiloride-sensitive Na(+)- and HCO3(-)-dependent mechanism. (1990) (76)
The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport. (1989) (74)
Alpha 1-adrenoceptor stimulation increases intracellular pH and Ca2+ in cardiomyocytes through Na+/H+ and Na+/Ca2+ exchange. (1990) (74)
Na+/Ca2+ antiport in cultured arterial smooth muscle cells. Inhibition by magnesium and other divalent cations. (1987) (74)
pH regulation in spread cells and round cells. (1990) (73)
Chloride transport activation by plasma osmolarity during rapid adaptation to high salinity of Fundulus heteroclitus (1995) (72)
Stimulation by glutamate receptors of arachidonic acid release depends on the Na+/Ca2+ exchanger in neuronal cells. (1993) (72)
Na+-H+ exchanger of human placental brush-border membrane: identification and characterization. (1986) (69)
Amiloride, a specific inhibitor for the Na+-driven flagellar motors of alkalophilic Bacillus. (1988) (69)
Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP. Evidence for the involvement of calmodulin-dependent kinases. (1988) (68)
Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts. (1988) (67)
Immunocytochemical and functional characterization of Na+ conductance in adult alveolar pneumocytes. (1992) (67)
Regulation of intracellular pH in the perfused heart by external HCO3- and Na(+)-H+ exchange. (1993) (64)
Specific inhibition of the Na(+)-driven flagellar motors of alkalophilic Bacillus strains by the amiloride analog phenamil (1990) (64)
Increase in thermosensitivity of tumor cells by lowering intracellular pH. (1993) (64)
Participation of a K(+) channel modulated directly by cGMP in the speract-induced signaling cascade of strongylocentrotus purpuratus sea urchin sperm. (2000) (63)
Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 1. Mechanism of inhibition by amiloride analogues. (1988) (61)
Bicarbonate determines cytoplasmic pH and suppresses mitogen-induced alkalinization in fibroblastic cells. (1988) (61)
Inhibition of na/h antiport activity in sugar beet tonoplast by analogs of amiloride. (1987) (59)
Estimation of the number and turnover rate of Na+/H+ exchangers in lymphocytes. Effect of phorbol ester and osmotic shrinking. (1987) (57)
A derivative of amiloride blocks both the light-regulated and cyclic GMP-regulated conductances in rod photoreceptors (1987) (56)
Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. (1987) (56)
Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition. (1988) (56)
Na-H antiport in cultured rat aortic smooth muscle: its role in cytoplasmic pH regulation. (1987) (55)
Insulin-induced cytoplasmic alkalinization and glucose transport in muscle cells. (1986) (55)
Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. (1988) (55)
Inhibition of K+ efflux and dehydration of sickle cells by [(dihydroindenyl)oxy]alkanoic acid: an inhibitor of the K+ Cl- cotransport system. (1989) (54)
Differentiation of human promyelocytic HL 60 cells by retinoic acid is accompanied by an increase in the intracellular pH. The role of the Na+/H+ exchange system. (1987) (54)
Na(+)-dependent and -independent Cl-/HCO3- exchangers in cultured rabbit esophageal epithelial cells. (1993) (53)
Na(+)-H+ and Na(+)-dependent Cl(-)-HCO3- exchange control pHi in vascular smooth muscle. (1990) (52)
Microtubule integrity is necessary for the epithelial barrier function of cultured thyroid cell monolayers. (1995) (52)
The cellular pool of Na+ channels in the amphibian cell line A6 is not altered by mineralocorticoids. Analysis using a new photoactive amiloride analog in combination with anti-amiloride antibodies. (1989) (52)
Isolation and properties of fibroblast mutants overexpressing an altered Na+/H+ antiporter. (1986) (51)
A role for Na+/Ca2+ exchange in the generation of superoxide radicals by human neutrophils. (1990) (51)
Intracellular-pH dependence of Na-H exchange and acid loading in quiescent and arginine vasopressin-activated mesangial cells. (1990) (50)
Inhibition of epidermal growth factor-induced mitogenesis by amiloride and an analog: evidence against a requirement for Na+/H+ exchange. (1984) (50)
Angiotensin II activates Na+-H+ exchange and stimulates growth in cultured vascular smooth muscle cells (1988) (49)
Mechanisms of HCl-induced lowering of intracellular pH in rabbit esophageal epithelial cells. (1993) (48)
Na+-Ca2+ exchange in human neutrophils. (1988) (48)
Amiloride-sensitive Na+ pathways in capillary endothelial cell swelling during hemorrhagic shock. (1992) (48)
The control of mediator release from RBL-2H3 cells: roles for Ca2+, Na+, and protein kinase C1. (1987) (48)
Astrocytic swelling in traumatic-hypoxic brain injury. Beneficial effects of an inhibitor of anion exchange transport and glutamate uptake in glial cells. (1989) (47)
Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: inhibition by amiloride and its derivatives. (1985) (47)
Evidence for a halide-binding site in halorhodopsin. (1983) (46)
Amiloride and Its Analogs: Unique Cation Transport Inhibitors (1992) (44)
The Na(+)-H+ exchanger of the placental brush-border membrane is pharmacologically distinct from that of the renal brush-border membrane. (1990) (44)
Angiotensin II and potassium activate different calcium entry mechanisms in rat adrenal glomerulosa cells. (1989) (44)
Studies of pHi in rabbit esophageal basal and squamous epithelial cells in culture. (1992) (44)
Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated urodeoxycholate, and increased ursodeoxycholate glucuronidation. (1988) (43)
Osmotic activation of Na(+)-H+ exchange in human endothelial cells. (1990) (42)
Inhibition of synaptosomal membrane Na+-Ca2+ exchange transport by amiloride and amiloride analogues. (1985) (42)
Fetal lung epithelial cells contain two populations of amiloride-sensitive Na+ channels. (1993) (40)
Characterisation of proton fluxes across the cytoplasmic membrane of the yeast Saccharomyces cerevisiae. (1991) (40)
Photoaffinity labeling of the epithelial sodium channel. (1986) (40)
Improved recovery from a traumatic-hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor. (1987) (39)
Kinetics and peculiarities of thermal inactivation of volume-induced Na+/H+ exchange, Na+,K+,2Cl- cotransport and K+,Cl- cotransport in rat erythrocytes. (1993) (37)
A Na(+)-dependent Ca2+ exchanger generates the sustained increase in intracellular Ca2+ required for T cell activation. (1992) (37)
Ca2+ mobilization can occur independent of acceleration of Na+/H+ exchange in thrombin-stimulated human platelets. (1988) (37)
Amiloride and analogues inhibit Na(+)-H+ exchange and cell proliferation in AR42J pancreatic cell line. (1990) (37)
Amiloride and amiloride analogs inhibit Na+/K+-transporting ATPase and Na+-coupled alanine transport in rat hepatocytes. (1988) (37)
Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta. (1991) (37)
Effect of partial Na pump and Na-H exchange inhibition on [Ca]i during acidosis in cardiac cells. (1991) (37)
Purification and subunit structure of the [3H]phenamil receptor associated with the renal apical Na+ channel. (1987) (36)
The mechanism of action of amiloride. (1988) (36)
Characteristics of the Na+-H+ antiporter in the intact renal proximal tubular cell. (1986) (36)
Ultrastructural features of a brain injury model in cat (1988) (36)
Activation of proximal tubular Na(+)-H+ exchange by angiotensin II. (1992) (36)
Interaction of amiloride and its analogues with adenosine A1 receptors in calf brain. (1990) (36)
Culture-induced alterations in alveolar type II cell Na+ conductance. (1993) (36)
Successive inactivation of the force-generating units of sodium-driven bacterial flagellar motors by a photoreactive amiloride analog. (1994) (36)
Na/H exchange-dependent cell volume and pH regulation and disturbances. (1988) (35)
Regulation of pH in rat papillary tubule cells in primary culture. (1987) (35)
[3H]ethylpropylamiloride, a radio‐labelled diuretic for the analysis of the Na+/H+ exchange system. Its use with kidney cell membranes. (1984) (35)
5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death (1992) (35)
Synergistic alpha-1 and alpha-2 adrenergic stimulation of rat proximal nephron Na+/H+ exchange. (1989) (34)
IGF-I regulation of Na(+)-K(+)-ATPase in rat arterial smooth muscle. (1997) (34)
Inhibition of colonic Na+ transport by amiloride analogues. (1989) (34)
Identification of amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells. Stimulation by 12-O-tetradecanoyl-phorbol-13-acetate. (1987) (34)
Cell volume regulation in human neutrophils: 2-(aminomethyl)phenols as Cl- channel inhibitors. (1993) (34)
Activation of the Na+/H+ antiport is not required for lectin-induced proliferation of human T lymphocytes. (1986) (34)
Extracellular ATP stimulates an amiloride-sensitive sodium influx in human lymphocytes. (1990) (34)
Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles. (1985) (33)
Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. (1990) (33)
Ursodeoxycholic acid choleresis: relationship to biliary HCO-3 and effects of Na+-H+ exchange inhibitors. (1988) (32)
Arginine vasopressin stimulates net fluid secretion in a polarized subculture of cyst-forming MDCK cells. (1991) (32)
Protein kinase C-mediated intracellular alkalinization in rat and rabbit aortic smooth muscle cells. (1987) (31)
Effects of amiloride on isolated Malpighian tubules of the yellow fever mosquito (Aedes aegypti) (1992) (31)
Enhancement of ricin cytotoxicity in Chinese hamster ovary cells by depletion of intracellular K+: evidence for an Na+/H+ exchange system in Chinese hamster ovary cells (1985) (31)
Characterization of the mitochondrial Na+H+ exchange. The effect of amiloride analogues (1988) (30)
Involvement of calcium and protein kinase C in the activation of the Na+/H+ exchanger in cultured bovine aortic endothelial cells stimulated by extracellular ATP. (1989) (30)
Na+/H+ exchange modulates the production of leukotriene B4 by human neutrophils. (1989) (30)
Taurine indirectly increases [Ca]i by inducing Ca2+ influx through the Na+-Ca2+ exchanger (1998) (30)
Intracellular pH in Human Resistance Arteries in Essential Hypertension (1991) (29)
Studies on L‐640,035: a novel antagonist of contractile prostanoids in the lung (1984) (29)
Phenamil: An irreversible inhibitor of sodium channels in the toad urinary bladder (2005) (29)
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. (1987) (29)
Intracellular pH in vascular smooth muscle: regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms. (1995) (29)
Low-dose glucocorticoids stimulate electroneutral NaCl absorption in rat colon. (1989) (29)
Photolabeling of tonoplast from sugar beet cell suspensions by [h]5-(N-methyl-N-isobutyl)-amiloride, an inhibitor of the vacuolar na/h antiport. (1990) (28)
Amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells. Stimulation by prolactin and other mitogens. (1987) (28)
New amiloride analogue as hapten to raise anti-amiloride antibodies. (1986) (28)
[3H]phenamil, a radiolabelled diuretic for the analysis of the amiloride-sensitive Na+ channels in kidney membranes. (1986) (28)
HCl-induced cell edema in rabbit esophageal epithelium: a bumetanide-sensitive process. (1995) (28)
Atrial natriuretic peptide and cGMP inhibit Na+/H+ antiporter in vascular smooth muscle cells in culture. (1994) (28)
Relationship among activation of the Na+/H+ antiporter, ornithine decarboxylase induction, and DNA synthesis. (1987) (28)
Calcium dependency of frequency-stimulated atrial natriuretic peptide secretion. (1994) (28)
Effects of amiloride analogues on Na+ transport in toad bladder membrane vesicles. Evidence for two electrogenic transporters with different affinities toward pyrazinecarboxamides. (1987) (28)
Single-cell analysis of the intracellular pH and its regulation during the monocytic differentiation of U937 human leukemic cells. (1988) (28)
Sodium-Lithium Exchange and Sodium-Proton Exchange Are Mediated by the Same Transport System in Sarcolemmal Vesicles From Bovine Superior Mesenteric Artery (1989) (28)
The effect of amiloride analogs on taste responses in gerbil (1990) (28)
Thermosensitization by increasing intracellular acidity with amiloride and its analogs. (1994) (27)
Ion transport mechanisms in rat parotid intralobular striated ducts. (1994) (27)
Actions of bradykinin and related peptides on rabbit coeliac artery rings (1989) (27)
Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters (2003) (27)
Na(+)-H+ exchange is not important for pancreatic HCO3- secretion in the pig. (1992) (26)
Effects of barium and 5-(N-ethyl-N-isopropyl)-amiloride on proximal tubule ammonia transport. (1992) (26)
Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype. (1991) (26)
Intracellular [Na+], Na+ pathways, and fluid transport in cultured bovine corneal endothelial cells. (2004) (26)
Effects of HMA, an analog of amiloride, on the thermosensitivity of tumors in vivo. (1994) (25)
Na(+)-Ca2+ exchange activity in central nerve endings. II. Relationship between pharmacological blockade by amiloride analogues and dopamine release from tuberoinfundibular hypothalamic neurons. (1990) (25)
Electrogenic sodium absorption in rabbit cecum in vitro. (1988) (25)
Intracellular pH and cell adhesion to solid substrate (1988) (24)
Effects of 5-(N, N Hexamethylene) Amiloride on Action Potentials, Intracellular Na, and pH of Guinea Pig Ventricular Muscle In Vitro (1994) (24)
Interactions of chloride and amiloride with the renal Na+/H/ antiporter. (1988) (24)
Na+ influx is mediated by Na(+)-K(+)-2Cl- cotransport and Na(+)-H+ exchange in sublingual mucous acini. (1993) (24)
Evidence of alpha 1-adrenergic----protein kinase C----Na+/H+ antiporter-dependent increase in pinealocyte intracellular pH. Role in the adrenergic stimulation of cGMP accumulation. (1989) (24)
Effects of serotonin on intracellular pH and contraction in vascular smooth muscle. (1992) (23)
Conductive sodium pathway with low affinity to amiloride in LLC-PK1 cells and other epithelia. (1988) (23)
Sodium-calcium exchanger in cultured human retinal pigment epithelium. (1997) (23)
Properties of the Na+-dependent Cl-/HCO3- exchange system in U937 human leukemic cells. (1987) (23)
Delineation of the role of a Na+/Ca2+ exchanger in regulating intracellular Ca2+ in T cells. (1993) (23)
Regulation of cytoplasmic pH of cultured bovine corneal endothelial cells in the absence and presence of bicarbonate (1988) (23)
Effects of amiloride and its analogues on [3H]batrachotoxinin-A 20-alpha benzoate binding, [3H]tetracaine binding and 22Na influx. (1988) (23)
Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters. (1989) (22)
Modulation of bovine aortic alpha-2 receptors by Na+, 5'-guanylylimidodiphosphate, amiloride and ethylisopropylamiloride: evidence for receptor G-protein precoupling. (1990) (22)
Species‐specific Mn2+/Mg2+ antiport from Mg2+‐loaded erythrocytes (1990) (22)
Sodium Channel Blockers Are Vasodilator As Well As Natriuretic and Diuretic Agents (1985) (22)
Amiloride and 5-(N-ethyl-N-isopropyl) amiloride inhibit medium acidification and glucose metabolism by the fission yeast Schizosaccharomyces pombe. (1993) (22)
IP3-and cAMP-induced responses in isolated olfactory receptor neurons from the channel catfish (1992) (21)
Identification and purification of a renal amiloride-binding protein with properties of the Na+-H+ exchanger. (1989) (20)
Na+ transport in human proximal colonic apical membrane vesicles. (1994) (20)
Ouabain. A stimulator of atrial natriuretic peptide secretion and its mechanism of action. (1993) (20)
Recombinant human interleukin 1-stimulated Na+/H+ exchange is not required for differentiation in pre-B lymphocyte cell line, 70Z/3. (1987) (20)
Brain anti-cytoxic edema agents. (1990) (20)
Different development of apical and basolateral Na-H exchangers in LLC-PK1 renal epithelial cells: characterization by inhibitors and antisense oligonucleotide. (1994) (20)
Influence of atrial natriuretic factor on 5-(N-ethyl-N-isopropyl)amiloride-sensitive 22Na+ uptake in rabbit aorta. (1989) (20)
Regulation of cytoplasmic pH in rat sublingual mucous acini at rest and during muscarinic stimulation (1992) (20)
Glucocorticoids inhibit colonic aldosterone-induced conductive Na+ absorption in adrenalectomized rat. (1992) (20)
Alpha 2-adrenergic receptors regulate Na(+)-H+ exchange via a cAMP-dependent mechanism. (1990) (19)
Inhibition of Na+ influx and DNA synthesis in human fibroblasts and neuroblastoma-glioma hybrid cells by amiloride analogs. (1983) (19)
Volume‐dependent K+ and Cl‐ fluxes in rat thymocytes. (1993) (19)
HCO3(-)-dependent intracellular pH regulation in the premature myocardium. (1992) (19)
Cytoplasmic pH change induced by leukotriene B4 in human neutrophils. (1988) (19)
Na+-H+ and Na+-Ca2+ exchange in glomerulosa cells: possible role in control of aldosterone production. (1988) (19)
Regulation of amino acid uptake by phorbol esters and hypertonic solutions in rat thymocytes (1986) (19)
Conductive cation transport in apical membrane vesicles prepared from fetal lung. (1994) (19)
Intracellular pH and Catecholamine Secretion from Bovine Adrenal Chromaffin Cells (1991) (19)
The role of transmembrane cationic gradients in immune complex stimulation of human polymorphonuclear leukocytes (1988) (19)
The Role of the Na+/H+ Antiporter in Human Neutrophil NADPH‐Oxidase Activation (1988) (18)
Effects of pHi on Na(+)-H+, Na(+)-dependent, and Na(+)-independent C1(-)-HCO3-exchangers in vascular smooth muscle. (1991) (18)
Sodium‐Lithium Exchange in Sarcolemmal Vesicles From Canine Superior Mesenteric Artery (1988) (18)
Agonist-specific role for Na+-H+ antiport in prostaglandin release from microvessel endothelium. (1989) (18)
Inhibition by 5-N-(4-chlorobenzyl)-2',4'-dimethylbenzamil of Na+/Ca2+ exchange and L-type Ca2+ channels in isolated cardiomyocytes. (1997) (18)
Inhibition of taste responses to Na+ salts by epithelial Na+ channel blockers in gerbil (1990) (18)
Effect of Na+/H+ exchange inhibitors on agonist-induced contraction of rat aorta. (1988) (17)
Chloride conductance of apical membrane in cultured porcine thyroid cells activated by cyclic AMP (1992) (17)
Characterization of the mitochondrial Na+-H+ exchange. The effect of amiloride analogues. (1988) (17)
Modulation of intracellular pH by secretagogues and the Na+/H+ antiporter in cultured bovine chromaffin cells (1991) (17)
Vascular effects of tetramethylpyrazuie: direct interaction with smooth muscle α-adrenoceptors (1991) (17)
Polyvalent cations inhibit human neutrophil chemotaxis by interfering with the polymerization of actin. (1990) (17)
Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins. (1991) (16)
Na+-dependent activation of Na+-K+ pump in human myocardium during recovery from acidosis. (1989) (16)
Stimulation of Na+/H+ exchange is not required for induction of hypertrophy of renal cells in vitro. (1992) (16)
Mechanisms of Na+ transport in human distal colonic apical membrane vesicles. (1994) (16)
Na+ dependence of gonadotropin-releasing hormone action: characterization of the Na+/H+ antiport in pituitary gonadotropes. (1991) (16)
Intracellular accumulation of potent amiloride analogues by human neutrophils. (1987) (16)
Volume regulation determinants in isolated proximal tubules in hypertonic medium. (1989) (15)
Evidence for a DIOA-sensitive [K+,Cl-]-cotransport system in cultured vascular smooth muscle cells. (1990) (15)
The hydrophobic tryptic core of the porcine alpha 2-adrenergic receptor retains allosteric modulation of binding by Na+, H+, and 5-amino-substituted amiloride analogs. (1990) (15)
Alpha-adrenoceptors in vascular smooth muscle: all is not well. (1991) (15)
Leukotriene D4-induced proliferation of glomerular epithelial cells: PKC- and Na+-H+ exchanger-mediated response. (1989) (14)
Inner medullary collecting duct Na(+)-H+ exchanger. (1991) (14)
The influence of calcium, sodium, and the Na+/Ca2+ antiport on susceptibility to cytolysin/perforin-mediated cytolysis. (1990) (14)
Endothelin-induced contraction of human peripheral resistance vessels is partly dependent on stimulation of sodium-hydrogen exchange. (1989) (14)
Stimulation of Ca2+ uptake into epididymal bull spermatozoa by analogues of amiloride. (1990) (14)
The effect of sodium transport and calcium channel inhibitors on phorbol ester-induced contraction of bovine airway smooth muscle. (1993) (14)
Protection by benzamil against dysfunction and damage in rat myocardium after calcium depletion and repletion. (1990) (14)
The Neuronal Basis of Salt Sensitivity (1989) (14)
Inhibition of brain mitochondrial Ca2+ transport by amiloride analogues. (1985) (13)
Regulation of thyroid follicular volume by bidirectional transepithelial ion transport (1991) (13)
Inhibition of Na + / Ca 2 " exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride ( calcium influx / intracellular calcium stores / contractility ) (13)
Amiloride analogues induce responses in isolated rat cardiovascular tissues by inhibition of Na+/Ca2+ exchange (2004) (13)
Na+/H+ exchange modulates rat neutrophil mediated tumor cytotoxicity. (1991) (13)
Amiloride analogues inhibit proximal tubule metabolism. (1986) (13)
Mechanism of chloride uptake in rabbit corneal epithelium. (1989) (13)
Systemic blood acidosis in low-flow ischemia induces capillary luminal narrowing. (1994) (13)
Characterization of an apical sodium conductance in rabbit cecum. (1993) (13)
Intracellular pH in frog skin: effects of Na+, volume, and cAMP. (1988) (13)
Effect of amiloride on the compensatory renal growth that follows uninephrectomy in mice. (1989) (13)
Regulation of aldosterone biosynthesis by Na+/H+ antiport: relationships between intracellular pH and angiotensin II. (1989) (13)
Solubilization and reconstitution of renal brush border Na+-H+ exchanger. (1988) (12)
Solubilization and reconsitution of renal brush border Na+−H+ exchanger (2005) (12)
The relationship between mitogen-induced changes in the cytoplasmic pH and free Ca2+ concentration in rat thymocytes. (1990) (12)
The interaction of amiloride analogues with the Na+/H+ exchanger in kidney medulla microsomes. (1984) (12)
Influence of isolation media on synaptosomal properties: Intracellular pH, pCa, and Ca2+ uptake (1990) (12)
Possible involvement of Ca++ ions, protein kinase C and Na(+)-H+ antiporter in insulin-induced endogenous dopamine release from tuberoinfundibular neurons. (1990) (12)
Secretin stimulates bile ductules to secrete both H+ and HCO3(-)-ions. (1992) (12)
LLC-PK1 mutant with increased Na+-H+ exchange and decreased sensitivity to amiloride. (1988) (12)
Inhibition by amiloride analogues of Na+-dependent hexose uptake in LLC-PK1/Cl4 cells. (1987) (12)
A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro. (1991) (11)
Structure-activity relations of amiloride derivatives, acting as antagonists of cation binding on Na+/K(+)-ATPase. (1993) (11)
Calcium: its role in alpha 1-adrenergic stimulation of atrial natriuretic peptide secretion. (1992) (11)
Amiloride derivatives that block Na+/Ca2+ exchange inhibit spontaneous inward currents in Na+-loaded cardiac myocytes. (1987) (11)
A dextran-bound amiloride derivative is a selective inhibitor of Na+/H+ antiport. Application for studying the role of the antiporter in cellular proliferation in human fibroblasts. (1987) (11)
Intracellular acidification-induced alkali metal cation/H+ exchange in human neutrophils (1987) (10)
Alpha 2-adrenergic receptor-mediated regulation of intestinal calcium transport. (1985) (10)
Mechanism of hyperosmolality stimulation of ANP secretion: its dependency on calcium and sodium. (1995) (10)
The significance of the relative effects of loop diuretics and anti-brain edema agents on the Na+, K+, Cl− cotransport system and the Cl−/NaCO3− anion exchanger (1986) (10)
Bidirectional ion transport in thyroid: secretion of anions by monolayer cultures that absorb sodium. (1992) (10)
High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. (1991) (10)
Evidence for a Role for Na+‐H+ Exchange in Activation of Human Platelets by PAF (1987) (10)
Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. (1992) (10)
DNA intercalation and inhibition of topoisomerase II. Structure-activity relationships for a series of amiloride analogs. (1989) (10)
Kinetic properties of the Na+/H+ antiport of heart mitochondria. (1989) (10)
Na+-Ca2+ exchange and calcium permeability in canine basolateral membrane vesicles: the effects of dibutyryl cAMP and specific inhibitors. (1988) (10)
The intracellular localization of amiloride in frog skin (1983) (10)
The Na+/Ca2+ exchanger regulates cytolysin/perforin-induced increases in intracellular Ca2+ and susceptibility to cytolysis. (1992) (9)
Antagonistic effect of amiloride on alpha-2 adrenoceptor-mediated pigment aggregation: pharmacological heterogeneity between B-HT 920 and noradrenaline. (1991) (9)
An epithelial high-affinity amiloride-binding site, different from the Na+ channel. (1993) (9)
Characterization of chicken intestinal brush border membrane Na/H exchange. (1992) (9)
Sequential sodium-proton exchange in thrombin-induced human platelets. (1987) (9)
Modulation of kidney cell protein degradation by insulin. (1990) (9)
The Na+/H+ antiport in renal mitochondria. (1995) (9)
Determinants of ammonia entry along the rat proximal tubule during chronic metabolic acidosis. (1989) (9)
Inhibitory effect of local anesthetics on Na+/H+ antiporter in brush border membrane-reconstituted vesicles. (1990) (8)
Inhibition of Na/Ca exchange in pancreatic islet cells by 3',4'-dichlorobenzamil. (1991) (8)
Ion transport in rabbit proximal colon: effects of sodium, amiloride, cAMP, and epinephrine. (1994) (8)
Effect of 6-iodoamiloride in various models of experimental hypertension. (1988) (8)
Characterization of Na+-dependent and Na+-independent Mg2+ efflux from erythrocytes by amiloride derivatives (1989) (8)
Role of sodium in mediator release from human basophils. (1992) (8)
Inhibition of monoamine oxidase by analogues of amiloride. (1989) (8)
Intracellular pH in rat resistance arteries during the development of experimental hypertension. (1991) (8)
Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels: II. Side-chain modifications (2005) (8)
Mechanisms of regulatory volume increase in collecting duct cells. (1993) (7)
Leukotriene D4‐induced increases in the cytoplasmic pH of human myelocytic leukocytes (1988) (7)
Regulation of Intracellular pH in Human Platelets (2001) (7)
Distinct epitopes on amiloride. (1989) (7)
pH in principal cells of frog skin (Rana pipiens): dependence on extracellular Na+. (1988) (7)
High-performance liquid chromatographic determination of amiloride and its analogues in rat plasma. (1990) (7)
Inhibitory effects of amilorides on pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate accumulation: possible involvement of postreceptor mechanisms. (1990) (7)
Expression of a mammalian Na–H exchanger in muscle fibres of the giant barnacle (1985) (7)
Effects of amiloride and an analogue on ventricular arrhythmias, contracture and cellular injury during reperfusion in isolated and perfused guinea pig heart. (1991) (7)
Phenamil inhibits electrogenic sodium absorption in rabbit ileum. (1989) (7)
Low-dose glucocorticoids maintain Na-H exchange in distal colon of adrenalectomized rats. (1991) (7)
The mode of interaction of amiloride and some of its analogues with the adenosine A1 receptor (1992) (7)
Influence of amiloride derivatives on alpha-1 adrenergic receptor-induced contractions of the rabbit aorta. (1990) (6)
Activation of sodium transport mediates regulation of thyroid follicle volume in response to hypotonic media. (1993) (6)
Comparison with the Muscarinic Agonist Carbachol (1990) (6)
Control of ion transport in the thyroid: prostaglandin E2 activates cation transport on the basal membrane of cultured porcine thyroid cell monolayers. (1990) (6)
Preparation of 6-125I-labeled amiloride derivatives. (1988) (6)
Cytoplasmic alkalinization induced by insulin through an activation of Na(+)-H+ antiporter inhibits tyrosine hydroxylase activity in striatal synaptosomes. (1991) (6)
Pyrazine compounds and the measurement of cytosolic Ca2+. (1993) (6)
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, amiloride analogues, and renal Na+/H+ antiporter. (1987) (6)
Amiloride analogs induce the phosphorylation of elongation factor-2 in vascular endothelial cells. (1990) (6)
Treatment of tyramine-induced brain edema with anion transport inhibitor L-644,711. (1988) (5)
The depressant effects of some amiloride analogues on the slow outward K+ current and contraction of voltage-clamped frog muscle fibres. (1989) (5)
Effects of amiloride and 5-(N,N-hexamethylene)amiloride on dopaminergic and cholinergic neurotransmission. (1988) (5)
Comparison of the effectiveness of seven amiloride congeners as inhibitors of Na/H and Na/Ca antiport in cultured smooth muscle cells (1987) (5)
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC. (1993) (5)
Vascular effects of tetramethylpyrazine: direct interaction with smooth muscle alpha-adrenoceptors. (1991) (5)
Inhibitory effects of amiloride and its analogues on prostaglandin E2-stimulated fluid transport by cultured porcine thyroid cells: evidence for apical membrane Na+ channels. (1989) (4)
Regulation of the Na+/H+ antiporter: evidence for a membrane shuttling mechanism. (1993) (4)
Cytosolic pH changes in contracting canine trachealis smooth muscle. (1990) (4)
Direct inhibition of contractile apparatus by analogues of amiloride in the smooth muscle of guinea-pig taenia caecum and chicken gizzard. (1989) (4)
Volume- and catecholamine-dependent regulation of Na/H antiporter and unidirectional potassium fluxes in Salmo trutta red blood cells (1994) (4)
Paradoxical effects of amiloride analogs on protein phosphorylation and serotonin release induced by agonists in human platelets. (1988) (4)
Wound currents and wound healing in the newt, Notophthalmus viridescens (1990) (4)
Heterogeneity of the Na(+)-H+ antiport systems in renal cells. (1992) (4)
Evidence for the O-sulfo derivative of MK-447 as active metabolite of MK-447. (1991) (4)
Role of sodium in antigen-induced contraction of tracheal smooth muscle in dogs. (1993) (4)
Hyponatremia-induced brain edema in guinea pigs is reduced by treatment with the novel anion transport inhibitor L-644,711. (1989) (3)
5-(N,N-dimethyl)amiloride-sensitive Na-Li exchange in isolated specimens of human atrium. (1988) (3)
LLC-PK sub 1 mutant with increased Na sup + -H sup + exchange and decreased sensitivity to amiloride (1988) (3)
Effect of ethylisopropyl amiloride on intracellular pH regulation in cultured rat astrocytes. (1989) (3)
Effects of Na+/H+ exchange inhibition on cardiac reperfusion arrhythmias (1988) (3)
Characterization of Na/sup +/-linked and Na/sup +/-independent Cl/sup -//HCO/sub 3//sup -/ exchange systems in Chinese hamster lung fibroblasts (1988) (3)
Na+/H+ exchange in PAF-stimulated platelets. (1989) (3)
Development of reversible and irreversible inhibitors of Na+/Ca2+ exchange in pituitary plasma membrane vesicles. (1984) (3)
Rapid Communication: Exaggerated Depressor Response to 6-lodoamiloride in NaCl-Sensitive Spontaneously Hypertensive Rats (1988) (2)
Ursodeoxycholic acid choleresis: Relationship to biliary HCO sup minus sub 3 and effects of Na sup + -H sup + exchange inhibitors (1988) (2)
Evidence for a Na+/H+ exchanger at the basolateral membranes of the isolated frog skin epithelium: Effect of amiloride analogues (1987) (2)
Binding of3H-phenamil, an irreversible amiloride analog, to toad urinary bladder: effects of aldosterone and vasopressin (2005) (2)
Sodium–Proton (Na+/H+) Exchange Inhibition Increases Blood Pressure in Spontaneously Hypertensive Rat (1994) (2)
A Study of the Interaction between the Na+, K+ Pump and Na+ : Ca 2+ Exchange in Macrophages and Vascular Smooth Muscle Cells (1988) (2)
Electrogenic sodium transport in the developing rabbit cecum. (1989) (2)
Inhibition of Na+ flux in Chinese hamster ovary cells and Swiss 3T3 cells by a potent new derivative of amiloride, methylisopropyl-amiloride. (1986) (2)
Determination of active 5-(N,N-hexamethylene)amiloride in pig plasma. (1992) (2)
Amiloride analogs stimulate protein phosphorylation and serotonin release in human platelets. (1988) (1)
Mechanisms influencing sodium entry to cultured vascular smooth muscle. (1988) (1)
Characteristics of Two Different Na+‐H+ Antiport Systems in Several Epithelial and Nonepithelial Cell Lines (1989) (1)
Effects of anion exchange on intracellular pH and tension in basilar artery of dogs. (1996) (1)
Identification of apical membranes from tight epithelia using spin-labeled amiloride and electron paramagnetic resonance spectroscopy (2005) (1)
Effects of epidermal growth factor on gluconeogenesis and cellular redox state do not require Na+/H+ exchange or Na+/K+-ATPase activities (1994) (1)
Effect of autologous serum on human leucocyte Na+/H+ exchange and intracellular pH. (1990) (1)
Na-H Exchange Is a Major Determinant of Cellular Sodium Handling in Vascular Smooth-Muscle Cells (1986) (1)
[The role of ion transport system of sarcolemma in amino acid loss during myocardial perfusion with calcium-free medium and myocardium injury during "calcium paradox"]. (1999) (1)
An aldosterone regulated chicken intestine protein with high affinity to amiloride. (1997) (1)
Effects of 6-iodo-amiloride, a sodium channel blocker, on cardiovascular parameters in spontaneously hypertensive and Wistar-Kyoto rats. (1986) (1)
Actions ofamiloride analogues onprostacyclin synthesis byrataortic rings (1987) (1)
Inhibition of bradykinin-induced increases of cytosolic Ca++ by a novel amiloride analog. (1989) (1)
Intracellular pH and Contraction in Vascular Smooth Muscle (2005) (0)
Regulation of Intracellular ph in Beating Mammalian Cardiac Cells (1988) (0)
Inhibition by amiloride analogues of Na sup + -dependent hexose uptake in LLC-PK sub 1 /Cl sub 4 cells (1987) (0)
[Effect of blockers of the sarcolemmal anion transporter systems on the development of myocardial edema during ischemia and recovery of the contractile function during reperfusion]. (1999) (0)
[Effect of sarcolemmal ion-transporting system blockers on the intensity of heart damage during "calcium paradox"]. (2000) (0)
[Mechanisms of action of hypersodium medium on contractile activity of isolated rat heart]. (2001) (0)
18 Blockade of the Na+/H+ antiport in resistance arterioles from spontaneously hypertensive and Wlstar‐Kyoto rats with amilorlde analogues: evidence of a central role in vascular contraction (1988) (0)
Endothelin Stimulates Na/H Exchange in Human Peripheral Resistance Vessels but does not Inhibit Isolated Na/K ATPase (1989) (0)
[The importance of the ion-transport systems of the sarcolemma and sarcoplasmic reticulum in changing rat cardiac contractile function under a hypersodium medium]. (1999) (0)
Development of lnhibitory Ligands (1987) (0)
Exaggerated depressor response to 6-iodoamiloride in NaCl-sensitive spontaneously hypertensive rats. (1988) (0)
News of the Society for Microcirculation (1994) (0)
A study of the interaction between the Na+, K+ pump and Na+:Ca2+ exchange in macrophages and vascular smooth muscle cells. (1988) (0)
Angiotensin I1 Effect on Cytosolic pH in Cultured Rat Vascular Smooth Muscle Cells* (2001) (0)
Hormonal and pharmacologic regulation of sodium absorption in rabbit cecumin vitro (1992) (0)
Nordic Microcirculation Society (1994) (0)
5-(N,N-Hexamethylene) Amiloride is an Effective Inhibitor of Na/H Exchange in Human Leucocytes (1989) (0)
MECHANISMS INVOLVED IN 5-HT STIMULATION OF PROSTACYCLIN PRODUCTION BY BOVINE AORTIC SMOOTH MUSCLE CELLS (1987) (0)
Inhibition of Na/sup +/-dependent uptake of hexose and amino acids in LLC-PK1 cells by amiloride and amiloride-derivatives (1986) (0)
Renal Effects of Selective Alpha-1 and Alpha-2 Adre noceptor Agonists in Conscious , Normotensive Rats (2017) (0)
Amiloride inhibits the vasopressin-induced increase in epithelial water permeability (1990) (0)
[Dependence of myocardial damage on the anion composition and osmotic pressure in the extracellular fluid during "calcium paradox" in rats]. (1999) (0)
[The mechanisms of the effect of a high extracellular sodium concentration on the contractile activity of the isolated rat heart]. (1996) (0)
Mechanisms influencing Na+ entry in cultured vascular smooth muscle (1988) (0)

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