Ernst Mutschler
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(Suggest an Edit or Addition)Ernst Mutschler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Antagonist binding profiles of five cloned human muscarinic receptor subtypes. (1991) (613)
- P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand‐gated ion channels (1998) (559)
- PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. (1992) (307)
- Renal function in the elderly: impact of hypertension and cardiac function. (1997) (256)
- Predictability of the covalent binding of acidic drugs in man. (1993) (145)
- PPADS selectively antagonizes P2X‐purinoceptor‐mediated responses in the rabbit urinary bladder (1993) (137)
- Coadministration of albumin and furosemide in patients with the nephrotic syndrome. (1999) (131)
- p-fluoro-hexahydro-sila-difenidol: The first M2β-selective muscarinic antagonist (1988) (122)
- Selective antagonism by PPADS at P2X‐purinoceptors in rabbit isolated blood vessels (1994) (119)
- Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity (1995) (117)
- In vitro antispasmodic compounds of the dry extract obtained from Hedera helix. (1997) (117)
- Antimuscarinic action of methoctramine, a new cardioselective M-2 muscarinic receptor antagonist, alone and in combination with atropine and gallamine. (1987) (114)
- Active transport of the angiotensin‐II antagonist losartan and its main metabolite EXP 3174 across MDCK‐MDR1 and Caco‐2 cell monolayers (2000) (100)
- Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes. (1989) (100)
- Sequential nephron blockade breaks resistance to diuretics in edematous states. (1997) (94)
- Cardiovascular effects, pharmacokinetics, and converting enzyme inhibition of enalapril after morning versus evening administration (1993) (93)
- Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x‐purinoceptors (1994) (91)
- Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer's dementia. (1995) (88)
- Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in Vivo (1996) (84)
- Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea‐pig taenia coli and rat duodenum (1995) (82)
- Renal handling of drugs in the healthy elderly Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged (1999) (82)
- Clinical Pharmacokinetics and Pharmacodynamics of Torasemide (1998) (80)
- Diuretic Effectiveness of Hydrochlorothiazide and Furosemide Alone and in Combination in Chronic Renal Failure (1995) (77)
- Pharmacokinetics of Intrathecal Baclofen (1988) (76)
- Functional role in ligand binding and receptor activation of an asparagine residue present in the sixth transmembrane domain of all muscarinic acetylcholine receptors. (1994) (76)
- Investigation of the actions of PPADS, a novel P2X‐purinoceptor antagonist, in the guinea‐pig isolated vas deferens (1994) (73)
- Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type. (1990) (73)
- Muscarinic receptor subtypes in rat pancreatic islets: binding and functional studies. (1990) (71)
- Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. (1991) (70)
- Study of the contractile effect of 5-hydroxytryptamine (5-HT) in the isolated longitudinal muscle strip from guinea-pig ileum (1985) (69)
- HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats. (1998) (67)
- NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. (1998) (65)
- Identification of an intracellular tyrosine residue critical for muscarinic receptor-mediated stimulation of phosphatidylinositol hydrolysis. (1994) (58)
- Drug actions : basic principles and theraputic aspects (1995) (57)
- Human HT-29 colon carcinoma cells contain muscarinic M3 receptors coupled to phosphoinositide metabolism. (1989) (55)
- Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type. (1988) (54)
- Muscarinic acetylcholine receptors: structural basis of ligand binding and G protein coupling. (1995) (54)
- INTERACTION OF CIMETIDINE WITH METOPROLOL, PROPRANOLOL, OR ATENOLOL (1981) (54)
- Zinc changes AMPA receptor properties: Results of binding studies and patch clamp recordings (1996) (50)
- Selectivity profile of the novel muscarinic antagonist UH‐AH 37 determined by the use of cloned receptors and isolated tissue preparations (1991) (49)
- [Pharmacology of diuretics]. (2006) (49)
- Influence of ranitidine on plasma metoprolol and atenolol concentrations. (1983) (49)
- Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs (1995) (49)
- GERD 2003 – A Consensus on the Way Ahead (2003) (47)
- Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney. (1993) (46)
- Pharmacokinetic and Pharmacodynamic Aspects of an Ophthalmic Pilocarpine Nanoparticle-Delivery-System (1994) (46)
- WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties. (1993) (46)
- New functionally selective muscarinic agonists. (1993) (45)
- The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X(1) receptors. (2000) (45)
- Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling. (1994) (44)
- Structure‐activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes (1989) (43)
- Functional role of a cytoplasmic aromatic amino acid in muscarinic receptor-mediated activation of phospholipase C. (1994) (42)
- Vitamins C and E protect isolated cardiomyocytes against oxidative damage. (2000) (41)
- Cryptolepis sanguinolenta: antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors. (1992) (40)
- Blue native PAGE as a useful method for the analysis of the assembly of distinct combinations of nicotinic acetylcholine receptor subunits. (1999) (40)
- Determination of the bioavailability of the quaternary compound trospium chloride in man from urinary excretion data. (1986) (39)
- Time course and extent of angiotensin II antagonism after irbesartan, losartan, and valsartan in humans assessed by angiotensin II dose response and radioligand receptor assay (1999) (38)
- Stereoselectivity of the enantiomers of trihexyphenidyl and its methiodide at muscarinic receptor subtypes. (1988) (38)
- Chloroformates and isothiocyanates derived from 2-arylpropionic acids as chiral reagents: synthetic routes and chromatographic behaviour of the derivatives (1996) (35)
- A comparison of the antimuscarinic effects of pirenzepine and N-methylatropine on ganglionic and vascular muscarinic receptors in the rat. (1984) (34)
- Gemfibrozil and its oxidative metabolites: quantification of aglycones, acyl glucuronides, and covalent adducts in samples from preclinical and clinical kinetic studies. (2000) (34)
- Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism (2001) (32)
- Inhibition of angiotensin II pressor response and ex vivo angiotensin II radioligand binding by candesartan cilexetil and losartan in healthy human volunteers. (1997) (32)
- Pharmacokinetics of hydrochlorothiazide in relation to renal function (2004) (32)
- Vasoconstrictor responses via P2X‐receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery (1997) (31)
- Fluorimetric determination of atenolol in plasma and urine by direct evaluation of thin-layer chromatograms. (1979) (31)
- Functional state of the nephron and diuretic dose-response--rationale for low-dose combination therapy. (1994) (31)
- Measurement of Carvedilol Enantiomers in Human Plasma and Urine Using S‐Naproxen Chloride for Chiral Derivatization (1990) (31)
- Different binding properties of muscarinic M2-receptor subtypes for agonists and antagonists in porcine gastric smooth muscle and mucosa. (1988) (31)
- Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists. (2003) (30)
- Methylmethacrylate sulfopropylmethacrylate copolymer nanoparticles for drug delivery: Part III: Evaluation as drug delivery system for ophthalmic applications (1997) (30)
- Angiotensin II antagonism and plasma radioreceptor-kinetics of candesartan in man. (1998) (30)
- The interaction between H2-receptor antagonists and beta-adrenoceptor blockers. (1984) (29)
- Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers (1990) (29)
- [Nigragillin, a new alkaloid from the Aspergillus niger group. 1. Isolation and structure clarification of nigragillin and a dioxopiperazine]. (1969) (28)
- Comparative Pharmacodynamics and Pharmacokinetics of Candesartan and Losartan in Man (2000) (28)
- Ketoconazole concentrations in human skin blister fluid and plasma. (1984) (28)
- Fluorimetric determination of oxprenolol in plasma by direct evaluation of thin-layer chromatograms. (1979) (27)
- Nebivolol Increases Survival in Cardiomyopathic Hamsters with Congestive Heart Failure (1991) (26)
- Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects. (1991) (26)
- Abstracts of papers (2005) (26)
- Enantiospecific high-performance liquid chromatographic assay with fluorescence detection for the monoamine oxidase inhibitor tranylcypromine and its applicability in pharmacokinetic studies. (1992) (26)
- Biological recognition of enantiomeric silanes: Syntheses and antimuscarinic properties of optically active (2-aminoethyl)cyclohexyl(hydroxymethyl)phenylsilanes and related quaternary ammonium derivatives (1995) (26)
- Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. (1992) (25)
- Methylmethacrylate sulfopropylmethacrylate copolymer nanoparticles for drug delivery: Part II: arecaidine propargyl ester and pilocarpine loading and in vitro release (1997) (25)
- Interaction of atenolol with furosemide and calcium and aluminum salts (1981) (25)
- Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle (1997) (25)
- Stereoselectivity of the interaction of muscarinic antagonists with their receptors. (1989) (24)
- Pharmacokinetics of triamterene. (1983) (24)
- Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro‐difenidol and acetylenic analogues (1990) (24)
- Atenolol interaction with aspirin, allopurinol, and ampicillin (1983) (24)
- Carvedilol Stereopharmacokinetics in Rats: Affinities to Blood Constituents and Tissues (1993) (24)
- Pharmacokinetics of amiloride in renal and hepatic disease (2004) (23)
- (-)-(S)-flunoxaprofen and (-)-(S)-naproxen isocyanate: two new fluorescent chiral derivatizing agents for an enantiospecific determination of primary and secondary amines. (1989) (23)
- Pharmacokinetics of atenolol in relation to renal function (2004) (23)
- Clinical Experience with Atenolol in Patients with Chronic Liver Disease (1983) (23)
- [Fluorometric determination of propranolol and its metabolite n-desisopropylpropranolol in plasma and urine by direct meausrement of thin-layer chromatographic plates (author's transl]. (1977) (22)
- Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes (1996) (22)
- Enantiospecific High-Performance Liquid Chromatographic (HPLC) Determination of Baclofen and Its Fluoro Analogue in Biological Material (1988) (22)
- Activated α-alkyl-α-arylacetic acid enantiomers for stereoselective thin-layer chromatographic and high-performance liquid chromatographic determination of chiral amines (1984) (22)
- Predictions of in Vivo Plasma Concentrations from in Vitro Release Kinetics: Application to Doxepin Parenteral (I.M.) Suspensions in Lipophilic Vehicles in Dogs (1994) (21)
- Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists. (1994) (21)
- Conventional versus novel conditions for the in vitro dissolution testing of parenteral slow release formulations: application to doxepin parenteral dosage forms. (1993) (20)
- Determination of metoprolol enantiomers in plasma and urine using (S)-(-)-phenylethyl isocyanate as a chiral reagent. (1987) (20)
- Blockade of epithelial Na+ channels by triamterenes — Underlying mechanisms and molecular basis (1996) (20)
- Increase in magnesium plasma level after orally administered trimagnesium dicitrate (2004) (20)
- o-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist. (1988) (20)
- Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat. (1990) (19)
- Gemfibrozil absorption and elimination in kidney and liver disease (1990) (19)
- Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats (1995) (19)
- Characterization of muscarinic receptors mediating vasodilation in guinea-pig ileum submucosal arterioles by the use of computer-assisted videomicroscopy. (1992) (19)
- Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4. (1990) (19)
- Pharmacological discrimination between enantiomeric germanes by muscarinic receptors: a study on germanium/silicon bioisosterism (1996) (19)
- Simultaneous determination of (R)- and (S)-celiprolol in human plasma and urine: high-performance liquid chromatographic assay on a chiral stationary phase with fluorimetric detection. (1989) (19)
- Inhibition of uridinediphosphate glucuronyltransferase caused by furosemide (1980) (18)
- Fluorimetric determination of fluvoxamine or clovoxamine in human plasma after thin-layer chromatographic or high-performance liquid chromatographic separation. (1986) (18)
- [The spasmolytic activity of propiverine and some of its structural analogs]. (1987) (18)
- Single- and multiple-dose pharmacokinetics of R-(−)- and S-(+)-prenylamine in man (2004) (18)
- Effect of extracellular calcium concentration on potency of muscarinic agonists at M1 and M2 receptors in rabbit vas deferens. (1991) (18)
- A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites. (1998) (18)
- Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. (1989) (18)
- Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo (1988) (17)
- Influence of cardiac function on the diuretic and hemodynamic effects of the loop diuretic piretanide (1987) (17)
- Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus (1990) (17)
- The pharmacokinetics of tranylcypromine enantiomers in healthy subjects after oral administration of racemic drug and the single enantiomers. (1993) (17)
- Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3. (1992) (17)
- [Fluorimetric determination of amiloride in human plasma using thin-layer chromatography]. (1982) (17)
- Improved enantiospecific RP-HPLC assays for propranolol in plasma and urine with pronethalol as internal standard. (1991) (17)
- Intracellular pH Regulation in Bovine Aortic Endothelial Cells: Evidence of Both Na+/H+ Exchange and Na+-Dependent Cl–/HCO–3 Exchange (1998) (17)
- Novel ligands for P2 receptor subtypes in innervated tissues. (1999) (17)
- The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. (1995) (17)
- [Fluorometric determination of hydrochlorothiazide in body fluids by direct measurement of thin-layer chromatographic plates (author's transl)]. (1977) (17)
- Stimulation of ganglionic muscarinic M1 receptors by a series of tertiary arecaidine and isoarecaidine esters in the pithed rat. (1987) (17)
- Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component. (1988) (16)
- Simple and reliable radioreceptor assay for beta-adrenoceptor antagonists and active metabolites in native human plasma (2004) (16)
- Simultaneous determination of R- and S-prenylamine in plasma and urine by reversed-phase high-performance liquid chromatography. (1988) (16)
- Investigations on structure-activity relationships of arecaidine-derivatives on the guinea pig isolated atria. (1967) (16)
- Pharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney function (2004) (16)
- Pharmacokinetics of torasemide and its metabolites in healthy controls and in chronic renal failure (2004) (16)
- [Quantitative determination of diclofenac sodium in plasma by absorption measurement by means of direct evaluation of thin layer chromatograms]. (1980) (16)
- Muscarinic receptor subtypes--pharmacological, molecular biological and therapeutical aspects. (1995) (16)
- Stereoselectivity of (R)- and (S)-hexahydro-difenidol binding to neuroblastoma M1, cardiac M2, pancreatic M3, and striatum M4 muscarinic receptors. (1991) (15)
- Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila‐pridinol, diphenidol and sila‐diphenidol type (1993) (15)
- Determination of triamterene and its main metabolite hydroxytriamterene sulfate in human urine by capillary electrophoresis using ultraviolet absorbance and laser-induced fluorescence detection. (2002) (15)
- Rapid determination of the enantiomers of metoprolol, oxprenolol and propranolol in urine. (1987) (15)
- Contribution of M2 alpha and M2 beta muscarinic receptors to the action of cholinergic stimuli on prostaglandin synthesis and mechanical function in the isolated rabbit heart. (1988) (15)
- Lipophilisation of hydrophilic compounds. Consequences on transepidermal and intestinal transport of trospium chloride. (1987) (15)
- Influence of triamterene and hydroxytriamterene sulfuric acid ester on diuresis and saluresis in rats after oral and intravenous application. (1980) (15)
- Beta 1-adrenoceptor subtype selective antagonism of esmolol and its major metabolite in vitro and in man. Investigations using tricresylphosphate as red blood cell carboxylesterase inhibitor. (1995) (15)
- Sympathetic re-innervation after heart transplantation: dual-isotope neurotransmitter scintigraphy, norepinephrine content and histological examination (1995) (15)
- Human plasma and skin blister fluid levels of griseofulvin following a single oral dose (2004) (15)
- Depressor effects of isoguvacine propyl ester and isoarecaidine propyl ester due to stimulation of central GABA receptors in the cat. (1982) (14)
- Selective Inhibition of Muscarinic Receptors in Intestinal Smooth Muscle (1985) (14)
- Fluorimetric determination of the quaternary compound trospium and its metabolite in biological material after derivatization with benoxaprofen chloride. (1985) (14)
- In vivo non-linear intestinal permeability of celiprolol and propranolol in conscious dogs: evidence for intestinal secretion. (1998) (14)
- Low-dose reserpine/thiazide combination in first-line treatment of hypertension: efficacy and safety compared to an ACE inhibitor. (1997) (14)
- Rate-limiting biotransformation of triamterene is mediated by CYP1A2. (2005) (14)
- The renin-angiotensin-aldosterone system: focus on its distinct role in arterial hypertension and its various inhibitors as a therapeutic strategy to effectively lower blood pressure. (1996) (13)
- 2-methylimidazol-1-yl-substituted analogs of hexahydro-difenidol (HHD) and hexahydro-sila-difenidol (HHSiD) as m3 receptor-preferring muscarinic antagonists: A study on C/Si bioisosterism (2002) (13)
- Quality of cefotaxime sodium preparations. (1995) (13)
- Regioisomeric 3-, 4- and 5-aminomethyl isoxazoles: synthesis and muscarinic activity (1995) (13)
- Modulation of electrolyte excretion by potassium retaining diuretics. (1992) (13)
- Functional characterization of muscarinic receptors in rat duodenum (1995) (13)
- Binding and functional properties of hexocyclium and sila‐hexocyclium derivatives to muscarinic receptor subtypes (1994) (13)
- Limitation on the use of amiloride in early renal failure (2004) (13)
- [Fluorimetric determination of furosemide and 4-chloro-5-sulfamoylanthranilic acid in plasma through direct interpretation of thin layer chromatographs]. (1977) (13)
- Blockade as an Alternative to Cardioplegic Arrest During Cardiopulmonary Bypass 1 1 This article h (1998) (13)
- 4-(6-methoxy-2-naphthyl)-2-butyl chloroformate enantiomers: new reagents for the enantiospecific analysis of amino compounds in biogenic matrices. (1996) (13)
- Dose‐Effect and Kinetic‐Dynamic Relationships of the (β-Adrenoceptor Blocking Properties of Various Doses of Talinolol in Healthy Humans (1995) (13)
- Digoxin concentrations in serum and cantharides blister fluid: Correlations with cardiac response (1987) (13)
- Cyclohexy (4-fluorophenyl)(3-piperidinopropyl)silanol ((itp)-fluoro-hexahydro-sila-difenidol, p-F-HSSiD) and derivatives: synthesis and antimuscarinic properties (1991) (13)
- Design and pharmacological characterization of selective P2-purinoceptor antagonists (1996) (13)
- The influence of cardiovascular and antiinflammatory drugs on thiazide-induced hemodynamic and saluretic effects (2006) (12)
- Delayed elimination of triamterene and its active metabolite in chronic renal failure (2004) (12)
- Current Status of Sustained Release Formulations in the Treatment of Hypertension (1999) (12)
- Kinetics of MAO inhibitors. (1983) (12)
- Human anatomy, physiology, and pathophysiology (1985) (12)
- Influence of monovalent cations on the binding of a charged and an uncharged (‘carbo’‐)muscarinic antagonist to muscarinic receptors (1996) (12)
- Selective blockade in vivo of cardiac muscarinic M2 receptors by a polymethylene tetramine, BHC-9C. (1987) (12)
- Influence of inflammatory disease on the clinical pharmacokinetics of atenolol and metoprolol. (1983) (12)
- Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide. (1994) (12)
- Cefodizime in serum and skin blister fluid after single intravenous and intramuscular doses in healthy volunteers (1987) (12)
- Muscarinic ganglionic stimulants: conformationally restrained analogues related to [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. (1986) (12)
- Low-dose segmental blockade of the nephron rather than high-dose diuretic monotherapy (2005) (12)
- Two different inhibitory effects of pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid on adenosine diphosphate-induced human platelet aggregation. (1995) (12)
- In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. (1993) (12)
- Influence of ranitidine on plasma metoprolol concentrations. (1983) (12)
- [Drug interactions. Mechanisms and clinical relevance]. (2003) (12)
- Plasma and urinary levels of triamterene and certain metabolites after oral administration to man (2004) (11)
- Ultrastructural localization of calcium in the myocardium of cardiomyopathic syrian hamsters. (1988) (11)
- The action of tertiary and quaternary arecaidine and dihydroarecaidine esters on the guinea pig isolated ileum. (1966) (11)
- Different muscarine receptors mediate the prejunctional inhibition of [3H]-noradrenaline release in rat or guinea-pig iris and the contraction of the rabbit iris sphincter muscle (1989) (11)
- Beta-blockade as an alternative to cardioplegic arrest during cardiopulmonary bypass. (1998) (11)
- Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. (1999) (11)
- An approach to reduce the number of skin samples in testing the transdermal permeation of drugs (1986) (11)
- Synthesis of the selective antimuscarinic agent 4- { (cyclohexylhydroxy(2-methoxyphenyl)silyl)· methyl} -1, 1-dimethylpiperazinium methyl sulfate {o-methoxy-sila-hexocyclium methyl sulfate) (1989) (11)
- THE EFFECT OF CYCLOSPORINE ON ELECTRICALLY PACED ISOLATED RAT CARDIOMYOCYTES (1991) (10)
- Characterization of postjunctional muscarinic receptors mediating contraction in rat anococcygeus muscle (1997) (10)
- Preparation and Properties of the Enantiomers of the Selective Antimuscarinic Agent 1-Cyclohexyl-1-phenyl-4-piperidino-1-butanol (Hexahydro-Difenidol). (1989) (10)
- Pharmacokinetic and pharmacodynamic interactions between phenprocoumon and atenolol or metoprolol. (1984) (10)
- Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis (2009) (10)
- Direct enantiospecific HPLC bioanalysis of (R,S)-atenolol on a chiral stationary phase. (1993) (10)
- [On the quantitative determination of ergot alkaloids after thin-layer chromatography]. (1967) (10)
- Interaction of metoprolol, propranolol and atenolol with concurrent administration of cimetidine (1982) (10)
- Stereoselectivity at muscarinic receptor subtypes: observations with the enantiomers of phenglutarimide. (1989) (10)
- The interaction of cimetidine with metoprolol, atenolol, propranolol, pindolol and penbutolol. (1983) (9)
- The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study. (2001) (9)
- Does cantharides blister fluid provide access to the peripheral compartment? (1982) (9)
- Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function (2004) (9)
- A New Rapid and Sensitive High‐Performance Liquid Chromatographic Assay for Diclofenac in Human Plasma (1995) (9)
- Sila-Pharmaca. Part 33. Synthesis and Properties of the Selective Antimuscarinic Agent Cyclohexylphenyl(3-piperidinopropyl)silanol. (1986) (9)
- Characterization of the prejunctional muscarinic receptors mediating inhibition of evoked release of endogenous noradrenaline in rabbit isolated vas deferens (2004) (9)
- Single-dose kinetics of oral propranolol, metoprolol, atenolol, and sotalol: relation to lipophilicity. (1985) (9)
- Absolute Configuration of the Enantiomers of the Antimuscarinic Agents Procyclidine and Tricyclamol Iodide: X-Ray Structural Analysis of (R)-1-[3-Cyclohexyl-3-hydroxy-3-phenylpropyl]-1-methylpyrrolidinium Iodide (1986) (9)
- Sila‐Pharmaca. Part 37. Preparation and Properties of the Enantiomers of the Antimuscarinic Agents Sila‐Procyclidine and Sila‐Tricyclamol Iodide: Optically Active Silanols with Silicon as the Centre of Chirality. (1987) (9)
- Pharmacodynamic Studies on the Angiotensin II Type 1 Antagonists Irbesartan and Candesartan Based on Angiotensin II Dose Response in Humans (2002) (9)
- Accumulation and adverse effects of metoprolol and propranolol after concurrent administration of cimetidine. (1983) (9)
- Interaction between the beta-adrenoceptor blockers metoprolol and atenolol with amitriptyline and their effects on oxidative liver metabolism. (1984) (9)
- Pharmacodynamic and kinetic considerations on diuretics as a basis for differential therapy (1991) (9)
- The pharmaceutical and biological availability of commercial preparations of furosemide. (1982) (9)
- Sila–pharmaca. Part 32. Crystal and molecular structures of the (R)-enantiomer and the racemate of the antimuscarinic agent (cyclohexyl)phenyl[2-(pyrrolidin-1-yl)ethyl]silanol (sila–procyclidine) (1985) (9)
- Saluretic effect of the loop diuretic torasemide in chronic renal failure (1990) (9)
- Thin-layer chromatographic separation and in situ fluorimetric determination of ofloxacin in plasma and pleural fluid. (1989) (9)
- Editorial from the president of the EUFEPS (1993) (9)
- Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function (2004) (9)
- Muscarinic Properties of Compounds Related to Arecaidine Propargyl Ester (2000) (9)
- Pharmacokinetics of carteolol in relation to renal function (2004) (8)
- [Structure-activity relationships of unsaturated esters of arecaidine and dihydroarecaidine]. (1973) (8)
- Effect of M2 muscarinic receptor antagonist 4-DAMP, on prostaglandin synthesis and mechanical function in the isolated rabbit heart. (1989) (8)
- Rats with portacaval shunt as a potential experimental pharmacokinetic model for liver cirrhosis: application to carvedilol stereopharmacokinetics. (1993) (8)
- The novel heteromeric bivalent ligand SB9 potently antagonizes P2Y(1) receptor-mediated responses. (2000) (8)
- The central action of various arecaidine esters (arecoline derivatives) on blood pressure and heart rate in the cat. Comparison with the peripheral effects. (1978) (8)
- Pharmacokinetics and pharmacodynamics of triamterene and hydrochlorothiazide and their combination in healthy volunteers. (1997) (8)
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- [On cyclic acetylcholine analogs of the aminophenol series]. (1967) (0)
- Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2 (2021) (0)
- Do molsidomine, organic nitrates, or antithrombotic agents prevent the cardiomyopathy of the Syrian hamster? (1992) (0)
- [On the structure-effect-relations in cyclic acetylcholine analogues of the aminophenol-series]. (1967) (0)
- [On relations between the distribution of electrons in monoguanylhydrazones and their pharmacological action]. (1967) (0)
- Use of (3S, 2'R) -glycopyrronium as medicine (1997) (0)
- Interaction Between Alcohol and Metoprolol or Atenolol in Social Drinking (1983) (0)
- [Analgesic activity of some reduced Mannich-bases of the monoacyl-biphenyl series (author's transl)]. (1976) (0)
- [Synthesis and pharmacological activities of cyclic analogues of fentanyl (author's transl)]. (1975) (0)
- Cefodizime inSerumandSkinBlister Fluid after Single Intravenous andIntramuscular DosesinHealthy Volunteers (1987) (0)
- Improved enantiospecific RP-HPLC assays for propranolol in plasma and urine with pronethalol as internal standard. (1991) (0)
- [Diuretic therapy in the aged]. (1990) (0)
- Centrally induced cardiovascular effects and kinetic behaviour of isoarecaidine propyl ester in the cat. (1982) (0)
- Investigations on the acute toxicity of acidic and basic triamterene derivatives. (1995) (0)
- [Isolation, structure determination and quantitative determination of a new dye from Claviceps purpurea Tul]. (1970) (0)
- Abstracts of papers medicinal chemistry meeting (2005) (0)
- [Synthesis of 1-,2-, and 3-(aminoacetyl)indoles and 1-(aminoacetyl)indolines (author's transl)]. (1978) (0)
- [Direct quantitative determination of Scilla glycosides on thin-layer chromatograms by means of remission measurements]. (1969) (0)
- [N-Aryl-derivatives of 3-substituted anthranilic acids (author's transl)]. (1976) (0)
- [Living collegenin and collagen]. (2003) (0)
- Pharmacokinetics and bioavailability of piretanide in healthy volunteers following intramuscular administration. (1987) (0)
- [Basic substituted 1,8-dioxo-octahydroxanthenes. 3. Transformotion of dialkylaminoethylchlorides using condensation products of glyoxylic acid]. (1972) (0)
- [Letter: Drug stability]. (1976) (0)
- Fluorimetric determination of dimethylaminohydroxypropoxytriamterene in biological fluids by direct evaluation of thin-layer chromatograms. (1985) (0)
- [Why does adequate tolerance of a lipid-lowering agent play such an important role?]. (1990) (0)
- [On the microbiological conversion of N-containing substrates. 4. On the microbiological conversion of 5-hydroxyindole through Clavic eps purpurea, Cordyceps militaris and Aspergillus oryzae]. (1968) (0)
- Enantiospecific assay method for beclobrinic acid and preliminary pharmacokinetic studies after beclobrate dosage (1990) (0)
- Cyclic Analogues of Agonists as a Tool for Structure-Activity Relationships (1981) (0)
- FC61 comparable diuretic effect following I.V. administration of equimolar doses of etacrynic acid and etacrynic acid-cystein conjugate in dogs (1994) (0)
- [Transdermal therapeutic systems]. (1987) (0)
- [Synthesis of the isomeric 3-(pyridyl)- and 3-(piperidyl)-5-hydroxyindoles (author's transl)]. (1975) (0)
- M1-selective muscarinic antagonists in peptic ulcer therapy. Proceedings of a workshop. October 2 and 3, 1987, Constance, FRG. (1988) (0)
- Synthesis and Muscarinic Activity of Isoxazole‐Substituted 1,2,5,6‐ Tetrahydropyridines. (1995) (0)
- Use of a pharmaceutically acceptable salt of (3R, 2'R) -3 - ((ciclopentilhidroxifenilacetil) oxy) -1,1-dimethylpyrrolidinium for preparing a medicament. (1997) (0)
- The portocaval shunt rat as a model to study pharmacokinetics in cirrhosis: Propranolol and its glucuronides (1990) (0)
- Thioctic Acid Prevents Oxidativedamage in Isolated Cardiac Myocytes (1998) (0)
- [Potenial analgesics, IX: synthesis and pharmacological test of derivatives of n-(piperidine-4-yl)anthranilic acid (author's transl)]. (1978) (0)
- SYNTHESIS AND PHARMACOLOGICAL SCREENING OF PYRIDINE ANALOGS OF FENTANYL (1979) (0)
- [Kinetics of the effect of acebutolol in multimorbid geriatric patients]. (1985) (0)
- Fluorimetric determination of levoprotiline in human plasma after thin-layer chromatographic or high performance liquid chromatographic separation. (1987) (0)
- Pharmacodynamics of Acebutolol in Geriatric Patients with Multiple Diseases (1986) (0)
- P187 celiprolol double peak occurrence and gastric motility: Nonlinear mixed effect modeling of bioavailability data obtained in dogs (1994) (0)
- P185 computer-assisted videomicroscopy: Effects of some antihypertensives on guinea-pig ileum resistance vessels (1994) (0)
- [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 17. Conformational behavior and cholinergic properties of arecaidine and sulfoarecaidine esters]. (1983) (0)
- Solubility and distribution coefficient of potassium and magnesium retaining triamterene derivatives (1996) (0)
- [Comparison of bumadizone-, phenylbutazone- and oxyphenbutazone-plasma levels after a single oral dose of phenylbutazone and of bumadizone, respectively (author's transl)]. (1981) (0)
- [Effect of a third electron dense center on the effect of aromatic bisguanylhydrazones]. (1968) (0)
- SILA DRUGS. 31. SYNTHESIS, STRUCTURE, AND PHARMACOLOGICAL PROPERTIES OF DIPHENYL(2-PIPERIDINOETHOXYMETHYL)SILANOL AND ITS CARBON ANALOG (1983) (0)
- [A statement on the future development of the pharmacy school]. (1996) (0)
- INVESTIGATIONS ON THE ANTIDIURETIC ACTIVITY OF SOME POTASSIUM AND MAGNESIUM RETAINING TRIAMTERENE DERIVATIVES IN RATS (1996) (0)
- Enantiomers of the Muscarinic Antagonist 1-Cyclohexyl-1-(4- fluorophenyl)-4-piperidino-1-butanol (p-Fluoro-hexahydro-difenidol): Synthesis, Absolute Configuration, and Enantiomeric Purity. (2010) (0)
- [Synthesis and pharmacological activity of carbocyclic analogs of muscarine (author's transl)]. (1974) (0)
- Abstracts of papers (1971) (0)
- Fluorine‐Containing Derivatives of the Muscarinic Antagonists Silapridinol and Siladifenidol: Syntheses and Antimuscarinic Properties. (1996) (0)
- [On the structure-function relation of cyclic acetylcholine analogues of the aminophenol series. 2. Pharmacologic studies on isolated rat and guinea pig uterus, on isolated guinea pig uterus, on isolated guinea pig auricle and on blood pressure of the rat]. (1968) (0)
- P211 characterization of phase-I metabolism of carvedilol in human liver microsomes (1994) (0)
- [Consensus conference "Therapy of chronic heart insufficiency" inaugurated by the Munich Collegium for Therapy Research e.V. together with the German Society for Cardiovascular Research]. (1993) (0)
- [Morphologic, biochemical and pharmacokinetic studies on suction blisters in relationship to their nature and time of formation]. (1985) (0)
- alpha-Alkyl-alpha-arylacetic acid derivatives as fluorescence markers for thin-layer chromatographic and high-performance liquid chromatographic assay of amines and alcohols. (1984) (0)
- POTENTIAL ANALGESICS, IX: SYNTHESIS AND PHARMACOLOGICAL TEST OF SUBSTITUTED N-(PIPERIDIN-4-YL)ANTHRANILIC ACID DERIVATIVES (1979) (0)
- [Pharmacokinetics of antihypertensive drugs in kidney and liver diseases]. (1983) (0)
- [On the affinity of arecaidine derivatives for acetylcholinesterase of guinea pig erythrocytes]. (1967) (0)
- [The role of ionic interaction of parasympathomimetic drugs (author's transl)]. (1975) (0)
- P170 diclofenac/codein phosphate combination: Relative bioavailability of suppositories as compared to film-coated tablets (1994) (0)
- Pharmacokinetics of (R)- and (S)-propranolol and their glucuronides in the elderly (1990) (0)
- Studies with triamterene derivatives for oral application. (1985) (0)
- Trends in medicinal chemistry : proceedings of the Ninth International Symposium on Medicinal Chemistry, Berlin, 1986 (1987) (0)
- Unsaturated Derivatives of the Muscarinic Antagonists Hexahydro‐sila‐ difenidol (HHSiD) and p‐Fluoro‐hexahydro‐sila‐difenidol (p‐F‐HHSiD) with an (E)‐Si‐CH=CH‐CH2‐N Moiety: Syntheses and Binding Affinities at Muscarinic Receptor Subtypes. (1996) (0)
- [Basic substituted tryptamines and tryptophols. 3. Pharmacologic studies on 1- and 2-position of basic substituted derivatives]. (1970) (0)
- Antiarrhythmic properties of triamterene derivatives in the coronary artery ligated rat model (1991) (0)
- [On the microbiological conversion of N-containing substrates. 1. On the microbiological acetylation of amines by Cordyceps militaris]. (1967) (0)
- [Azapropazone plasma levels in rheumatologic therapy with D-penicillamine combined with immunosuppressive agents]. (1977) (0)
- [On the use of homogeneous azeotropic mixtures in thin layer chromatography]. (1969) (0)
- [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs, 18. Synthesis and muscarine-type activity of sulfoarecaidine and sulfoisoarecaidine esters]. (1983) (0)
- [Synthesis of 1-(piperidinyl-4)-indolinones-(2) and-3,4-dihydrocarbostyriles (author's transl)]. (1974) (0)
- Synthesis , Structure and Antimuscarinic Properties (2013) (0)
- [Risk factors in hypertension: a disease with fatal consequences]. (2001) (0)
- [On the protein binding of bisguanylhydrazones of 4,4'-diacetyldiphenyl series as a function of structure]. (1968) (0)
- [On the use of homogenous azeotropic mixtures in thin-layer chromatography. 1]. (1968) (0)
- [Direct quantitative evaluation of thin layer chromatogramms by remission- and fluorescence measurement. 1. Microdetermination of xanthine derivatives in blood]. (1969) (0)
- [Determination of canrenone in biological fluids (author's transl)]. (1981) (0)
- Circadian pharmacokinetics and converting enzyme inhibition of enalapril maleate in healthy volunteers (1990) (0)
- [Stereochemistry of aralkylation on tropane nitrogen]. (1974) (0)
- LOCAL ANESTHETICALLY AND ANTIARRYTHMICALLY EFFECTIVE INDOLES AND INDOLINE DERIVATIVES, I. SYNTHESIS OF 1-, 2-, AND 3-(AMINOACETYL)INDOLES AND 1-(AMINOACETYL)INDOLINES (1978) (0)
- SYNTHESIS AND β‐SYMPATHOLYTIC ACTIVITY OF BASICALLY SUBSTITUTED 1,3‐DIOXOLAN‐2‐YL‐ AND 1,3‐DIOXAN‐2‐YL‐PHENOXYPROPANOLS (1978) (0)
- Using (3S, 2'R) -glycopyrronium as a medicament (1997) (0)
- Effect of Nebivolol on Survival of Cardiomyopathic Hamsters with Congestive Heart Failure (1991) (0)
- [On the basically substituted tryptamines and tryptophols. 1. Synthesis of in 1-position substituted derivateves]. (1967) (0)
- [Electron distribution and dissociation constants of pharmacologically active Arecaidine derivatives]. (1967) (0)
- Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3 (2021) (0)
- [On a difference in their effect on the heart of mono- and bisguanyl hydrazones]. (1966) (0)
- [Extraction of drugs. 4. Selective extraction properties of solvents]. (1969) (0)
- Preparation and Diuretic Properties of Novel Amiloride Analogues. (1993) (0)
- [Structure-effect relations in cyclic acetylcholine analogues of the pilocarpine series]. (1969) (0)
- The Cardiovascular Effects of Diuretics (1987) (0)
- Abstracts of papers medicinal chemistry meeting (2005) (0)
- Multiple-Dose Pharmacokinetics ofOfloxacin inSerum,Saliva, and SkinBlister Fluid ofHealthy Volunteers (1990) (0)
- [On the presence of atropine in Sclerotinia minor Jagger and Corticium rolfsii Curzi]. (1960) (0)
- FC31 kinetic-dynamic relationship of the renal effects of triamterene (1994) (0)
- [The importance of magnesium in therapy]. (1982) (0)
- [The hormonal system. Physiology and mechanism of action of hormones]. (1988) (0)
- Stereoselectivities in carvedilol phase-I metabolism Studies with human liver microsomes (1994) (0)
- The influence of aluminium hydroxide on the bioavailability of feprazone. Single dose study. (1985) (0)
- [Structure-activity relationship of N-methyl-3-pyrroline and N-methyl-pyrrolidine-3-carboxylic acid]. (1971) (0)
- [The direct quantitation of thin layer chromatograms by remission- and fluorescence measurement. 7. A rapid method for the determination of serotonin in urine (author's transl)]. (1974) (0)
- [Reversible inhibition of thrombocyte stimulation by acetylsalicylic acid and its role in antithrombotic therapy]. (1983) (0)
- Adenosine and its derivatives for use in the treatment of pain (2011) (0)
- Sila‐biperiden and endo‐Sila‐biperiden: Synthesis, Crystal Structures and Antimuscarinic Properties. (1994) (0)
- PHARMACOLOGY OF SELECTIVE MUSCARINIC LIGANDS RELATED TO MCN-A-343 (1995) (0)
- [On the microbiological conversion of N-containing substrates. 3. On the determination of the constitution oc conversion products of 5-hydroxyindole through Cordyceps militaris]. (1968) (0)
- [Determination of protein binding of some guanylhydrazones by means of Sephadex gel filtration]. (1970) (0)
- Use of pteridine derivatives for the treatment of cardiac arrhythmias (1984) (0)
- Synthesis of the Selective Antimuscarinic Agent 4-((Cyclohexylhydroxy-(2-methoxyphenyl)silyl)methyl)-1,1-dimethylpiperazinium Methyl Sulfate (o-Methoxysilahexocyclium Methyl Sulfate). (1989) (0)
- Effects of Piretanide on Sodium and Potassium Excretion and on Renal Hemodynamics (1991) (0)
- Muscarinic Ganglionic Stimulants: Conformationally Restrained Analogues Related to [4‐[[N‐(3‐Chlorophenyl)carbamoyl]oxy]‐2‐butynyl]trimethylammonium Chloride. (1986) (0)
- When should atheromatous renal artery stenosis be considered? A guide for the general physician (2003) (0)
- [Letter: Stress and trauma as cause of diabetes]. (1976) (0)
- New drug compositions (1996) (0)
- Use of a pharmaceutically suitable salt of (3R, 2'R) -3 - [(cyclopentil-hydroxyphenylacetyl) oxy] -1,1-dimethyl-pyrrolidinium for the preparation of a medicament (1997) (0)
- [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues. 16. Conformational behaviour and cholinergic properties of isoarecaidine and sulfoisoarecaidine esters]. (1983) (0)
- [Potential analgesics. 8. Synthesis and pharmacologic testing of 3-, 4- and 5-substituted N-arylanthranilic acids]. (1978) (0)
- Pteridine having pharmaceutical efficacy (1984) (0)
- [Pharmacokinetics and -dynamics of calcium antagonists in the elderly]. (1993) (0)
- [On the chemistry and pharmacology of the alkaloids damascenine and arecoline. 5. On structure-effect relations in cyclical acetylcholine derivatives of the arecoline and damascenine series]. (1966) (0)
- [Direct quantitative evaluation of thin layer chromatogramms by remission- and fluorescence measurement. 2. Determination of drugs in 2 combination preparations by remission measurements]. (1969) (0)
- [The content of free serotonin in urine after resection of part of the gastro-intestinal-tract (author's transl)]. (1975) (0)
- SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF CYCLIC ANALOGS OF FENTANYL (1976) (0)
- (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes of the Type (HOCH2)( C6H5)2Si(CH2)nNC5H10 (n = 2, 3) and Their Methiodides: Synthesis, Structure and Antimuscarinic Properties. (1994) (0)
- [Direct quantitative evaluation of thin-layer chromatograms by remission- and fluorescence measurement. 6. Determination of adrenaline, noradrenaline and dopamine from urine]. (1971) (0)
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What Schools Are Affiliated With Ernst Mutschler?
Ernst Mutschler is affiliated with the following schools: