Evan R. Simpson
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Chemistry Biology
Evan R. Simpson's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Chemistry Stanford University
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(Suggest an Edit or Addition)Evan R. Simpson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. (1994) (1516)
- Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. (1995) (1455)
- Effect of testosterone and estradiol in a man with aromatase deficiency. (1997) (1133)
- Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. (1998) (894)
- Sources of estrogen and their importance (2003) (851)
- Estrogen and spermatogenesis. (2001) (765)
- Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. (2000) (716)
- Aromatase--a brief overview. (2002) (707)
- Control of mammary stem cell function by steroid hormone signalling (2010) (674)
- Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. (1999) (633)
- Aromatase expression in endometriosis. (1996) (554)
- Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. (1988) (474)
- Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. (1996) (460)
- Minireview: Aromatase and the Regulation of Estrogen Biosynthesis-Some New Perspectives. (2001) (457)
- Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. (2006) (431)
- Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. (2002) (416)
- Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. (1981) (411)
- Aromatase expression in health and disease. (1997) (368)
- Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. (1986) (366)
- History of aromatase: saga of an important biological mediator and therapeutic target. (2009) (362)
- A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. (1993) (351)
- A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom). (1994) (336)
- Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment. (2004) (329)
- Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. (1989) (325)
- 17α-Hydroxylase/17,20-Lyase Deficiency: From Clinical Investigation to Molecular Definition* (1991) (322)
- Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. (1988) (286)
- Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. (1993) (282)
- Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. (1996) (271)
- Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis (1979) (263)
- Assay of aromatase activity. (1991) (259)
- Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. (1991) (258)
- Estrogen--the good, the bad, and the unexpected. (2005) (251)
- Ad4BP/SF-1 Regulates Cyclic AMP-induced Transcription from the Proximal Promoter (PII) of the Human Aromatase P450 (CYP19) Gene in the Ovary (*) (1995) (246)
- The Role of Local Estrogen Biosynthesis in Males and Females (2000) (241)
- Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER (*) (1995) (237)
- Update on estrogen signaling (2003) (234)
- An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene. (2000) (234)
- Liver Receptor Homologue-1 (LRH-1) Regulates Expression of Aromatase in Preadipocytes* (2002) (233)
- Endocrine physiology of the placenta. (1981) (215)
- Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries. (1993) (214)
- Expression of the CYP19 (aromatase) gene: an unusual case of alternative promoter usage (1997) (209)
- Bone Has a Sexually Dimorphic Response to Aromatase Deficiency (2000) (206)
- Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. (2009) (205)
- Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic Neuroprotection (2003) (204)
- Effects of aging and obesity on aromatase activity of human adipose cells. (1985) (199)
- A three‐dimensional model of aromatase cytochrome P450 (1995) (196)
- Immunolocalization of aromatase, 17 alpha-hydroxylase and side-chain-cleavage cytochromes P-450 in the human ovary. (1989) (195)
- Transcriptional regulation of steroid hydroxylase genes by corticotropin. (1986) (194)
- p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. (2015) (194)
- Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. (2011) (194)
- Of mice and men: the evolving phenotype of aromatase deficiency (2006) (193)
- Local estrogen biosynthesis in males and females. (1999) (190)
- Aromatase: biologic relevance of tissue-specific expression. (2004) (184)
- Regulation of estrogen biosynthesis by human adipose cells. (1989) (184)
- Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse. (2004) (183)
- Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. (1996) (181)
- Competitive reverse transcription-polymerase chain reaction analysis indicates that levels of aromatase cytochrome P450 transcripts in adipose tissue of buttocks, thighs, and abdomen of women increase with advancing age. (1994) (181)
- Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta. (1991) (176)
- Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. (2001) (173)
- Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. (1981) (172)
- Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450. (1978) (172)
- Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence. (1986) (172)
- Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. (1983) (172)
- Peroxisome Proliferator-activated Receptor γ Ligands Inhibit Estrogen Biosynthesis in Human Breast Adipose Tissue: Possible Implications for Breast Cancer Therapy (2000) (169)
- The cholesterol side-chain cleavage system of bovine adrenal cortex. (1967) (166)
- Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodies. (1991) (162)
- The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen. (1988) (160)
- Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. (1995) (157)
- Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture. (1994) (156)
- Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. (1987) (154)
- A CRE-like sequence that binds CREB and contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP19) gene (1997) (151)
- Estrogen receptor beta protects against acoustic trauma in mice. (2008) (149)
- Endocrine disorders associated with inappropriately high aromatase expression (1997) (147)
- Aromatase-deficient (ArKO) mice accumulate excess adipose tissue (2001) (144)
- Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450AROM), and their use in its purification. (1985) (144)
- Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse. (2003) (143)
- Cholesterol metabolism in cancer cells in monolayer culture. III. Low‐density lipoprotein metabolism (1981) (143)
- Structural Characterization of Normal and Mutant Human Steroid 17α- Hydroxylase Genes: Molecular Basis of One Example of Combined 17α- Hydroxylase/17,20 Lyase Deficiency (1988) (142)
- The multiple roles of estrogens and the enzyme aromatase. (2010) (142)
- Recognizing rare disorders: aromatase deficiency (2007) (142)
- Aromatization of androgens in women: current concepts and findings. (2002) (142)
- Regulation of cholesterol and progesterone synthesis in human placental cells in culture by serum lipoproteins. (1980) (141)
- Aromatase-deficient mice spontaneously develop a lymphoproliferative autoimmune disease resembling Sjogren's syndrome. (2004) (141)
- Role of aromatase in sex steroid action. (2000) (140)
- Regulation by follicle-stimulating hormone of the synthesis of aromatase cytochrome P-450 in human granulosa cells. (1987) (139)
- Expression of messenger ribonucleic acid species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle. (1990) (137)
- Lipoprotein utilization and cholesterol synthesis by the human fetal adrenal gland. (1981) (137)
- Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells (1996) (136)
- The effect of ether anaesthesia stress on cholesterol-side-chain cleavage and cytochrome P450 in rat-adrenal mitochondria. (1972) (135)
- Obesity and breast cancer: progress to understanding the relationship. (2010) (134)
- Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. (1997) (132)
- The ovarian phenotype of the aromatase knockout (ArKO) mouse (2001) (131)
- Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase (2010) (130)
- Characterization of the fertility of male aromatase knockout mice. (2001) (127)
- Low-density lipoprotein as a potential vehicle for chemotherapeutic agents and radionucleotides in the management of gynecologic neoplasms. (1981) (126)
- Mitochondrial malic enzyme: the source of reduced nicotinamide adenine dinucleotide phosphate for steroid hydroxylation in bovine adrenal cortex mitochondria. (1969) (126)
- Aromatase expression of human osteoblast-like cells (1998) (124)
- Tissue-specific promoters regulate aromatase cytochrome P450 expression (1993) (122)
- Spectral properties of rat adrenal-mitochondrial cytochrome P-450. (1974) (119)
- CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors. (1994) (118)
- Cytochromes P-450scc, P-450(17)alpha, adrenodoxin, and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase in bovine follicles and corpora lutea. Changes in specific contents during the ovarian cycle. (1986) (117)
- The cholesterol side-chain cleavage system of the adrenal cortex: a mixed-function oxidase. (1966) (117)
- Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells (1988) (116)
- The phenotype of the aromatase knockout mouse reveals dietary phytoestrogens impact significantly on testis function. (2002) (116)
- Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads. (1993) (116)
- Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat. (1992) (115)
- Angiotensin II inhibits luteinizing hormone-stimulated cholesterol side chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture. (1990) (114)
- Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. (2007) (114)
- Aromatase research and its clinical significance. (2010) (113)
- Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter (2010) (112)
- The Role of Lipoproteins in the Regulation of Progesterone Secretion by the Human Corpus Luteum (1982) (111)
- Regulation of aromatase activity of stromal cells derived from human adipose tissue. (1982) (111)
- Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture (1997) (111)
- Effect of estrogen deficiency in the male: the ArKO mouse model (2002) (109)
- Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer. (2005) (108)
- Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. (1994) (107)
- Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. (2009) (106)
- Estrogen actions on follicle formation and early follicle development. (2004) (105)
- Functional aromatase expression in porcine adrenal gland and testis. (1996) (105)
- Changes in content of cytochrome P450(17)alpha, cytochrome P450scc, and 3-hydroxy-3-methylglutaryl CoA reductase in developing rat ovarian follicles and corpora lutea: correlation with theca cell steroidogenesis. (1987) (105)
- Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. (2004) (104)
- Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification. (1992) (103)
- Aromatase gene expression in adipose tissue: Relationship to breast cancer (1994) (101)
- Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450. (1984) (100)
- Estrogen regulates development of the somatic cell phenotype in the eutherian ovary (2002) (99)
- Conversion of plasma progesterone to deoxycorticosterone in men, nonpregnant and pregnant women, and adrenalectomized subjects. (1980) (98)
- A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome (2007) (98)
- Aromatase and its inhibitors: significance for breast cancer therapy. (2002) (98)
- Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis. (1991) (97)
- Estrogen Deficient Male Mice Develop Compulsive Behavior (2007) (96)
- Plasma lipoproteins in follicular fluid of human ovaries. (1980) (96)
- Growth factors suppress and phorbol esters potentiate the action of dibutyryl adenosine 3',5'-monophosphate to stimulate aromatase activity of human adipose stromal cells. (1986) (95)
- Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. (1998) (93)
- Bone phenotype of the aromatase deficient mouse (2001) (93)
- The insulin-like growth factor, somatomedin C, induces the synthesis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in ovarian cells. (1986) (92)
- Expression of mRNA encoding basic fibroblast growth factor (bFGF) in bovine corpora lutea and cultured luteal cells. (1991) (92)
- Regulation of estrogen biosynthesis in human adipose stromal cells. Effects of dibutyryl cyclic AMP, epidermal growth factor, and phorbol esters on the synthesis of aromatase cytochrome P-450. (1987) (91)
- Aromatase in aging women. (1999) (90)
- 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. (1991) (89)
- Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis (1985) (89)
- Polymerase chain reaction amplification fails to detect aromatase cytochrome P450 transcripts in normal human endometrium or decidua. (1993) (88)
- The role of low density, high density, and very low density lipoproteins in steroidogenesis by the human fetal adrenal gland. (1980) (88)
- Regulation of steroid hydroxylase gene expression is multifactorial in nature. (1989) (87)
- Ovarian steroid receptors and their role in ovarian function (2002) (87)
- Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer (2015) (86)
- Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism. (2013) (86)
- Secretion of progesterone and prostaglandins by cells of bovine corpora lutea from three stages of the luteal phase. (1988) (86)
- Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells. (1981) (86)
- Deletion of a phenylalanine in the N-terminal region of human cytochrome P-450(17 alpha) results in partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. (1989) (85)
- Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA. (1986) (85)
- Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer. (2013) (85)
- Adipose aromatase gene expression is greater in older women and is unaffected by postmenopausal estrogen therapy (2005) (84)
- Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6. (1998) (84)
- Induction of synthesis of mitochondrial steroidogenic enzymes of bovine adrenocortical cells by analogs of cyclic AMP. (1984) (82)
- Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin: evidence for a previously unidentified COOH-terminal peptide. (1985) (82)
- Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. (2002) (82)
- Levels of messenger ribonucleic acid encoding cholesterol side-chain cleavage cytochrome P-450, 17 alpha-hydroxylase cytochrome P-450, adrenodoxin, and low density lipoprotein receptor in bovine follicles and corpora lutea throughout the ovarian cycle. (1987) (80)
- Characterization of complementary deoxyribonucleic acid for human adrenocortical 17α-hydroxylase: A probe for analysis of 17α-hydroxylase deficiency (1987) (80)
- Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma. (1980) (79)
- Obesity and breast cancer: role of inflammation and aromatase. (2013) (79)
- Studies on the synthesis of sterol carrier protein-2 in rat adrenocortical cells in monolayer culture. Regulation by ACTH and dibutyryl cyclic 3',5'-AMP. (1987) (79)
- Immunolocalization of cholesterol side-chain-cleavage cytochrome P-450 and 17 alpha-hydroxylase cytochrome P-450 in bovine ovarian follicles. (1986) (78)
- Cholesterol synthesis in human fetal tissues. (1982) (77)
- EFFECT OF ACTH ON ADRENAL MITOCHONDRIAL CYTOCHROME P‐450 IN THE RAT * (1973) (76)
- Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: incorporation of a steroidogenic pathway into nonsteroidogenic cells. (1988) (75)
- Effect of ACTH on cholesterol side-chain cleavage in rat adrenal mitochondria. (1972) (75)
- Aromatase activity of membrane fractions of human adipose tissue stromal cells and adipocytes. (1983) (75)
- Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy. (2000) (74)
- Decline in the concentration of low-density lipoprotein-cholesterol in human fetal plasma near term. (1983) (74)
- Regulation of aromatase expression in human tissues (2004) (74)
- Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. (2005) (73)
- Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue (2004) (73)
- The roles of activins, inhibins and estrogen in early committed follicles (2000) (73)
- Plasma lipoprotein regulation of progesterone biosynthesis by human corpus luteum tissue in organ culture. (1981) (73)
- The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis. (2003) (71)
- Exon-specific northern analysis and rapid amplification of cDNA ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P 450 (CYP19) expression in human ovary (1993) (71)
- The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language (2012) (71)
- Endocrine-related cancers and the role of AMPK (2013) (70)
- Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression (1999) (70)
- Differential expression of factors involved in fat metabolism with age and the menopause transition. (2005) (70)
- Aromatase expression in women's cancers. (2008) (69)
- Tissue‐Specific Estrogen Biosynthesis and Metabolism (2001) (68)
- Genetic mutations resulting in estrogen insufficiency in the male (1998) (67)
- Impaired spatial reference memory in aromatase-deficient (ArKO) mice (2003) (67)
- Estrogen Actions on Follicle Formation and Early Follicle Development1 (2004) (67)
- Regulation of cholesterol side-chain cleavage and 17 alpha-hydroxylase/lyase activities in proliferating human theca interna cells in long term monolayer culture. (1989) (67)
- Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer. (2016) (67)
- Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. (1998) (67)
- THE DETECTION OF DIFFERENT STATES OF THE P‐450 CYTOCHROMES IN ADRENAL MITOCHONDRIA; CHANGES INDUCED BY ACTH (1973) (66)
- Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis. (1993) (66)
- The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture. (1994) (66)
- Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast. (1996) (66)
- Canadian Mennonites and individuals residing in the Friesland region of the Netherlands share the same molecular basis of 17α-hydroxylase deficiency (1992) (66)
- Demonstration of tissue-specific promoters in nonprimate species that express aromatase P450 in placentae. (1995) (65)
- Uptake and degradation of lipoproteins by human trophoblastic cells in primary culture. (1980) (64)
- Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450. (1993) (64)
- Alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in adipose tissue of women. (1997) (64)
- Regulation of adenosine 5',monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state. (2006) (63)
- The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad. (2004) (63)
- Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice (2008) (63)
- Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice (2004) (62)
- Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells. (1981) (61)
- Role of CRE-Binding Protein (CREB) in Aromatase Expression in Breast Adipose (2003) (61)
- Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo (2011) (61)
- The road to ovulation: the role of oestrogens. (2001) (61)
- The role of serum lipoproteins in steroidogenesis by the human fetal adrenal cortex. (1979) (58)
- Endogenous Estrogen Deficiency Reduces Proliferation and Enhances Apoptosis-Related Death in Vascular Smooth Muscle Cells: Insights From the Aromatase-Knockout Mouse (2004) (58)
- Impaired Acetylcholine-Induced Release of Nitric Oxide in the Aorta of Male Aromatase-Knockout Mice: Regulation of Nitric Oxide Production by Endogenous Sex Hormones in Males (2003) (58)
- 3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1. (1992) (57)
- Cholesterol side-chain cleavage, cytochrome P450, and iron-sulfur protein in human placental mitochondria. (1978) (57)
- The binding of high and low density lipoproteins to human placental membrane fractions. (1982) (57)
- Alternative promotion of aromatase P-450 expression in the human placenta (1992) (56)
- A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. (2011) (56)
- Aromatase expression in a feminizing adrenocortical tumor. (1996) (56)
- Bovine steroid 21-hydroxylase: regulation of biosynthesis. (1986) (56)
- Partial resolution of the mixed-function oxidase involved in the cholesterol side-chain cleavage reaction in bovine adrenal mitochondria. (1967) (56)
- Cholesterol metabolism in cancer cells in monolayer culture. VI. Metabolism of high-density lipoprotein. (1982) (56)
- Estrogen and adiposity—Utilizing models of aromatase deficiency to explore the relationship (2007) (56)
- Adrenal cells in tissue culture. V. On the specificity of the stimulation of 11beta-hydroxylation by adrenocorticotropin. (1970) (56)
- Regulation of LKB1 expression by sex hormones in adipocytes (2012) (55)
- Deoxycorticosterone biosynthesis in human kidney: potential for formation of a potent mineralocorticosteroid in its site of action. (1980) (55)
- Therapeutic potential of Liver Receptor Homolog-1 modulators (2012) (54)
- Effect of cell density and confluency on cholesterol metabolism in cancer cells in monolayer culture. (1981) (53)
- Compound heterozygous mutations (Arg 239----stop, Pro 342----Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency. (1992) (53)
- Proliferating human granulosa-lutein cells in long term monolayer culture: expression of aromatase, cholesterol side-chain cleavage, and 3 beta-hydroxysteroid dehydrogenase. (1990) (52)
- HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma (2013) (52)
- Uptake and degradation of plasma lipoproteins by human choriocarcinoma cells in culture. (1979) (51)
- Functional modification of pituitary somatotropes in the aromatase knockout mouse and the effect of estrogen replacement. (2004) (51)
- Induction of 11 beta-hydroxylase by corticotropin in primary cultures of bovine adrenocortical cells. (1983) (50)
- Deoxycorticosterone biosynthesis from progesterone in kidney tissue of the human fetus. (1981) (50)
- Regulation by plasma lipoproteins of progesterone biosynthesis and 3-hydroxy-3-methyl glutaryl coenzyme a reductase activity in cultured human choriocarcinoma cells. (1978) (50)
- Effect of adrenocorticotropin on steroid 21-hydroxylase synthesis and activity in cultured bovine adrenocortical cells. Increased synthesis in the absence of increased activity. (1983) (50)
- Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads. (1994) (50)
- Regulation of Synthesis and Activity of Cytochrome P-450 Enzymes in Physiological Pathways (1986) (50)
- Effects of Cyclic AMP and Andre‐gens on in vitro Brain Aromatase Enzyme Activity During Prenatal Development in the Rat (1992) (50)
- Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex. (1982) (49)
- Estrogen signaling in the regulation of female reproductive functions. (2010) (49)
- Aromatase as a Therapeutic Target in Endometriosis (2000) (49)
- Combined 17α-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17α-hydroxylase cytochrome P-450 (1988) (49)
- Ligands for the Peroxisomal Proliferator-Activated Receptor γ and the Retinoid X Receptor Inhibit Aromatase Cytochrome P450 (CYP19) Expression Mediated by Promoter II in Human Breast Adipose. (2002) (48)
- Estrogen biosynthesis in THP1 cells is regulated by promoter switching of the aromatase (CYP19) gene. (1997) (47)
- Sequencing of cDNA inserts encoding aromatase cytochrome P-450 (P-450AROM) (1987) (47)
- Effects of adrenocorticotropin on 17 alpha-hydroxylase activity and cytochrome P-450(17 alpha) synthesis in bovine adrenocortical cells. (1985) (47)
- Synthesis of the cholesterol side-chain cleavage enzymes in cultured rat ovarian granulosa cells: induction by follicle-stimulating hormone and dibutyryl adenosine 3',5'-monophosphate. (1986) (46)
- Human chorionic gonadotropin binding to human fetal testes as a function of gestational age. (1982) (45)
- Combined 17α-Hydroxylase/17,20-Lyase Deficiency due to a 7-Basepair Duplication in the N-Terminal Region of the Cytochrome P45017α (CYP17) Gene* (1990) (45)
- Structural characterization of the bovine CYP17 (17α-hydroxylase) gene (1989) (45)
- Metabolism of low density lipoprotein by human fetal adrenal tissue. (1980) (45)
- Estrogen deficiency results in apoptosis in the frontal cortex of adult female aromatase knockout mice (2009) (44)
- Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. (1989) (44)
- Studies on the regulation of the onset of steroid hormone biosynthesis in fetal rabbit gonads. (1979) (44)
- PRMT2 and RORγ expression are associated with breast cancer survival outcomes. (2014) (44)
- Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency. (1992) (44)
- Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin by follicle-stimulating hormone, 8-bromo-cyclic AMP, and low density lipoprotein in cultured bovine granulosa cells. (1984) (43)
- Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer. (2015) (43)
- Validation of new aromatase monoclonal antibodies for immunohistochemistry: progress report (2003) (43)
- Models of aromatase insufficiency. (2004) (43)
- Transcriptional control of local estrogen formation by aromatase in the breast (2015) (43)
- Expression of mRNA species encoding steroidogenic enzymes in the rat ovary. (1991) (43)
- Tissue-specific promoters regulate aromatase cytochrome P450 expression. (1993) (43)
- Vasoactive intestinal peptide induces the synthesis of the cholesterol side-chain cleavage enzyme complex in cultured rat ovarian granulosa cells. (1986) (43)
- Prepulse inhibition of acoustic startle in aromatase knock‐out mice: effects of age and gender (2003) (42)
- Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone. (1980) (42)
- Obesity and breast cancer: mechanisms and therapeutic implications. (2012) (42)
- Hypercholesterolemia due to elevated low density lipoprotein-cholesterol in newborns with anencephaly and adrenal atrophy. (1983) (42)
- Production rate of deoxycorticosterone in women during the follicular and luteal phases of the ovarian cycle: the role of extraadrenal 21-hydroxylation of circulating progesterone in deoxycorticosterone production. (1980) (42)
- Aromatase deficiency confers paradoxical postischemic cardioprotection. (2011) (42)
- Estrogen Is Not Directly Required for Oocyte Developmental Competence1 (2004) (42)
- Cellular characterization of adipose tissue from various body sites of women. (1996) (42)
- Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture. (1985) (42)
- Expression of Neural 5α-Reductase Messenger Ribonucleic Acid: Comparison to 5α-Reductase Activity during Prenatal Development in the Rat* (1990) (41)
- Immunolocalization of cholesterol side-chain-cleavage cytochrome P-450 and ultrastructural studies of bovine corpora lutea. (1986) (41)
- Upregulation of estrogen receptors in the forebrain of aromatase knockout (ArKO) mice (2000) (41)
- Aromatase-deficient (ArKO) mice have reduced blood pressure and baroreflex sensitivity. (2004) (41)
- Deletion within the CYP17 gene together with insertion of foreign DNA is the cause of combined complete 17 alpha-hydroxylase/17,20-lyase deficiency in an Italian patient. (1991) (40)
- Regulation of cytochrome P-45011 beta gene expression by adrenocorticotropin. (1985) (40)
- Distinct nuclear receptor expression in stroma adjacent to breast tumors (2013) (40)
- De novo synthesis of cholesterol by the human fetal adrenal gland. (1981) (39)
- Regulation by cyclic AMP of the genes encoding steroidogenic enzymes: when the light finally shines … (1990) (38)
- Estrogen biosynthesis in adipose tissue: regulation by paracrine and autocrine mechanisms. (1996) (38)
- Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes. (2004) (37)
- Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency. (1988) (37)
- TGF-β1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells (2000) (37)
- Promoter-specific effects of metformin on aromatase transcript expression (2011) (37)
- Regulation of aromatase activity of cultured adipose stromal cells by catecholamines and adrenocorticotropin (1984) (36)
- Effect of aging and obesity on aromatase activity of human adipose cells. (1987) (36)
- Effects of adrenocorticotropic hormone on low density lipoprotein receptors of human fetal adrenal tissue. (1981) (36)
- Breast cancer and expression of aromatase in breast adipose tissue (1994) (35)
- Biology of Aromatase in the Mammary Gland (2000) (35)
- Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex (1997) (35)
- Regulation of human fetal testicular secretion of testosterone: low-density lipoprotein-cholesterol and cholesterol synthesized de novo as steroid precursor. (1983) (35)
- Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts (2010) (35)
- Aromatase expression is increased in BRCA1 mutation carriers (2009) (35)
- Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene (2009) (35)
- Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts (2012) (35)
- Estrogen, a fundamental player in energy homeostasis (2005) (35)
- Aromatase and Prostaglandin Inter-Relationships in Breast Adipose Tissue: Significance for Breast Cancer Development (2002) (35)
- Maintenance and regulation of 17 alpha-hydroxylase expression by bovine thecal cells in primary culture. (1993) (34)
- Lipoprotein-binding sites in human corpus luteum membrane fractions. (1982) (34)
- Hippocampal NMDA receptor subunit expression and watermaze learning in estrogen deficient female mice. (2005) (34)
- Tetradecanoyl phorbol acetate suppresses follicle-stimulating hormone-induced synthesis of the cholesterol side-chain cleavage enzyme complex in rat ovarian granulosa cells. (1987) (33)
- Synergistic induction of monooxygenase activity by glucocorticoids and polycyclic aromatic hydrocarbons in human fetal hepatocytes in primary monolayer culture. (1986) (33)
- CREB-Regulated Transcription Co-Activator Family Stimulates Promoter II-Driven Aromatase Expression in Preadipocytes (2013) (33)
- OVARIAN PHYSIOLOGY: FOLLICLE DEVELOPMENT, OOCYTE AND HORMONE RELATIONSHIPS (2009) (33)
- Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR. (1995) (32)
- Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts (2011) (32)
- Ontogeny of adrenal steroid hydroxylases: evidence for cAMP-independent gene expression (1987) (32)
- Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. (2012) (32)
- Effect of calcium ions on steroid-binding spectra and pregnenolone formation in rat-adrenal mitochondria. (1974) (32)
- Steroid secretion by ACTH-stimulated human fetal adrenal tissue during the first week in organ culture (1980) (31)
- A possible mechanism for the transfer of cytosol-generated NADPH to the mitochondrial mixed-function oxidases in bovine adrenal cortex: a malate shuttle. (1968) (31)
- Dexamethasone inhibits corticotropin-induced accumulation of CYP11A and CYP17 messenger RNAs in bovine adrenocortical cells. (1993) (31)
- Defective internalization of low density lipoprotein in epidermoid cervical cancer cells (1982) (30)
- LKB1 expression is inhibited by estradiol-17β in MCF-7 cells (2011) (30)
- Induction of 17α-hydroxylase (cytochrome P-45017α) activity by adrenocorticotropin in bovine adrenocortical cells maintained in monolayer culture☆ (1983) (30)
- Effect of calcium(ion) uptake by rat adrenal mitochondria on pregnenolone formation and spectral properties of cytochrome P-450. (1975) (30)
- Ovarian aromatase cytochrome P-450 mRNA levels correlate with enzyme activity and serum estradiol levels in anestrous, pregnant and lactating rats (1992) (30)
- Spin state changes in cytochrome P‐450 associated with cholesterol side chain cleavage in bovine adrenal cortex mitochondria (1971) (29)
- Ligands for the peroxisomal proliferator-activated receptor gamma and the retinoid X receptor inhibit aromatase cytochrome P450 (CYP19) expression mediated by promoter II in human breast adipose. (2002) (29)
- Effects of phytoestrogens on the ovarian and pituitary phenotypes of estrogen-deficient female aromatase knockout mice (2005) (29)
- Adrenodoxin biosynthesis by bovine adrenal cells in monolayer culture. Induction by adrenocorticotropin. (1982) (29)
- Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives. (1981) (29)
- Expression of a recombinant derivative of human aromatase P450 in insect cells utilizing the baculovirus vector system (1995) (29)
- Electron paramagnetic resonance studies of cytochrome P-450 and adrenal ferredoxin in single whole rat adrenal glands. Effect of corticotropin. (1976) (29)
- Expression of aromatase, estrogen receptors, and their coactivators in patients with endometrial cancer. (2006) (29)
- THE LEVELS OF PLASMA CHOLESTEROL IN THE HUMAN FETUS THROUGHOUT GESTATION (1982) (28)
- Another role highlighted for estrogens in the male: sexual behavior. (2000) (28)
- Regulation of the biosynthesis of steroidogenic enzymes. (1987) (28)
- Vasoactive intestinal peptide regulates cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene expression in granulosa cells from immature rat ovaries. (1987) (28)
- The role of receptor-mediated low-density lipoprotein uptake and degradation in the regulation of progesterone biosynthesis and cholesterol metabolism by human trophoblasts. (1981) (28)
- Regulation of aromatase activity of rat granulosa cells: induction of synthesis of NADPH-cytochrome P-450 reductase by FSH and dibutyryl cyclic AMP (1985) (27)
- Characterisation of aromatase expression in the human adipocyte cell line SGBS (2008) (27)
- Evidence for the presence of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin in fresh granulosa cells. Effects of follicle-stimulating hormone and cyclic AMP on cholesterol side chain cleavage cytochrome P-450 synthesis and activity. (1983) (27)
- Teasing out the role of aromatase in the healthy and diseased testis (2011) (27)
- The metabolism of pyruvate by bovine-adrenal-cortex mitochondria. (1971) (27)
- Regulation of expression of the genes encoding steroidogenic enzymes (1991) (27)
- Regulation of expression of the genes encoding steroidogenic enzymes in the ovary (1992) (27)
- Endogenous estrogen regulation of inflammatory arthritis and cytokine expression in male mice, predominantly via estrogen receptor alpha. (2010) (27)
- Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists. (1981) (27)
- The role of malic enzyme in bovine adrenal cortex mitochondria. (1968) (27)
- The 5'-flanking region of the ovarian promoter of the bovine CYP19 gene contains a deletion in a cyclic adenosine 3',5'-monophosphate-like responsive sequence. (1997) (26)
- Inverse relationship between ovarian aromatase cytochrome P450 and 5α-reductase enzyme activities and mRNA levels during the estrous cycle in the rat (1992) (26)
- Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus. (1980) (26)
- Multiple species of bovine adrenodoxin mRNA. Occurrence of two different mitochondrial precursor sequences associated with the same mature sequence. (1987) (26)
- Cholesterol synthesis by human fetal hepatocytes: effects of hormones. (1984) (26)
- Deoxycorticosterone sulfate biosynthesis in human fetal kidney. (1981) (26)
- Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease (2014) (26)
- Genetic Mutations Resulting in Loss of Aromatase Activity in Humans and Mice (2000) (26)
- Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for prepubertal gynecomastia in boys with Peutz-Jeghers syndrome. (2013) (25)
- Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. (2013) (25)
- Regulation of estrogen biosynthesis by human adipose cells in vitro (1987) (25)
- Effect of ACTH on the stability of mRNAs encoding bovine adrenocortical P-450scc, P-45011β, P-45017α, P-450C21 and adrenodoxin (1989) (25)
- The regulation of de novo synthesis of cholesterol in the human fetal adrenal gland by low density lipoprotein and adrenocorticotropin. (1980) (24)
- Oestrogens in male reproduction. (2000) (24)
- Investigations into the role of calcium ions in the control of steroid production by isolated adrenal zona glomerulosa cells of the rat. (1978) (24)
- Of mice and men: the many guises of estrogens. (2006) (24)
- A putative binding site for Sp1 is involved in transcriptional regulation of CYP17 gene expression in bovine ovary. (1997) (24)
- Sleep and Rest Regulation in Young and Old Oestrogen‐Deficient Female Mice (2006) (24)
- SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment (2017) (23)
- Rat adrenal 5α-reductase mRNA content and enzyme activity are sex hormone dependent (1991) (23)
- Hepatic Glucose Intolerance Precedes Hepatic Steatosis in the Male Aromatase Knockout (ArKO) Mouse (2014) (23)
- Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice (2015) (23)
- Regulation of cholesterol side-chain cleavage cytochrome P-450 gene expression in adrenal cells in monolayer culture (1986) (23)
- Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene. (2007) (23)
- Identification of a common molecular basis for combined 17α-hydroxylase/17,20-lyase deficiency in two Mennonite families (1989) (22)
- cAMP-dependent and tissue-specific expression of genes encoding steroidogenic enzymes in bovine luteal and granulosa cells in primary culture (1993) (22)
- Differential permeability of the blood-testis barrier during reinitiation of spermatogenesis in adult male rats. (2014) (22)
- Lipoproteins and the regulation of adrenal steroidogenesis. (1984) (22)
- Aromatase gene expression in adipose tissue: relationship to breast cancer. (1994) (22)
- Effects of epidermal growth factor on the synthesis of the cholesterol side-chain cleavage enzyme complex in rat ovarian granulosa cells in primary culture (1987) (22)
- Oestrogen, telomerase, ovarian ageing and cancer (2010) (22)
- 6 – Expression of Genes Encoding Steroidogenic Enzymes in the Ovary (1994) (22)
- Control of gene expression of adrenal steroid hydroxylases and related enzymes. (1986) (22)
- Effect of calcium on pregnenolone formation and cytochrome P-450 in rat adrenal mitochondria. (1975) (21)
- Detection of aromatase cytochrome P450, 17α-hydroxylase cytochrome P450 and NADPH:P450 reductase on the surface of cells in which they are expressed (1996) (21)
- Anti‐androgenic action by red clover‐derived dietary isoflavones reduces non‐malignant prostate enlargement in aromatase knockout (arko) mice (2003) (21)
- Inhibition of prostaglandin biosynthesis in human adipose tissue by glucocorticosteroids. (1983) (21)
- Mature bovine adrenodoxin contains a 14-amino-acid COOH-terminal extension originally detected by cDNA sequencing. (1987) (21)
- Effects of ACTH on steroidogenesis in bovine adrenocortical cells in primary culture--increased secretion of 17 alpha-hydroxylated steroids associated with a refractoriness in total steroid output. (1983) (21)
- Aromatase expression in the human fetal osteoblastic cell line SV-HFO. (2004) (21)
- Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size. (2012) (20)
- Prostaglandin E 2 Inhibits p 53 in Human Breast Adipose Stromal Cells : A Novel Mechanism for the Regulation of Aromatase in Obesity and Breast Cancer (2015) (20)
- The "malate shuttle" and control of steroid hydroxylation in the adrenal cortex. (1969) (19)
- Use of molecular probes to study regulation of aromatase cytochrome P-450. (1990) (19)
- Do intracrine mechanisms regulate aromatase expression? (1999) (19)
- Regulation of cholesterol metabolism by human trophoblastic cells in primary culture. (1981) (19)
- TGF-beta1 stimulates expression of the aromatase (CYP19) gene in human osteoblast-like cells and THP-1 cells. (2000) (19)
- Breast cancer prognosis predicted by nuclear receptor‐coregulator networks (2014) (19)
- Aromatization of androgens by human adipose tissue in vitro. (1983) (19)
- Metabolic events associated with steroid hydroxylation by the adrenal cortex. (1969) (19)
- Why do the clinical sequelae of estrogen deficiency affect women more than men? (1998) (18)
- Immunoblot analysis of cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin in corpora lutea of cyclic and late-pregnant sheep. (1988) (18)
- Generation and characterization of a mouse model of the metabolic syndrome: apolipoprotein E and aromatase double knockout mice. (2012) (18)
- Low density lipoprotein binding and de novo synthesis of cholesterol in the neocortex and fetal zones of the human fetal adrenal gland. (1982) (18)
- Intracellular potassium and steroidogenesis of isolated rat adrenal cells: effect of potassium ions and angiotensin II on purified zona glomerulosa cells. (1977) (18)
- Erratum to “Expression of transcripts of interleukin-6 and related cytokines by human breast tumors, breast cancer cells, and adipose stromal cells” [Mol. Cell. Endocrinol. 118 (1996) 215–220] (1996) (18)
- Biosynthesis of cholesterol side-chain cleavage cytochrome P-450 in human fetal adrenal cells in culture. (1983) (18)
- Erratum: Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads (Journal of Clinical Endocrinology and Metabolism (1993) 77 (1616-1621)) (1994) (17)
- Induction of synthesis of bovine adrenocortical cytochromes P-450scc, P-45011β, P-450c21, and adrenodoxin by prostaglandins E2 and F2α and cholera toxin (1984) (17)
- Regulation of cholesterol metabolism by human choriocarcinoma cells in culture: effect of lipoproteins and progesterone on cholesteryl ester synthesis. (1980) (17)
- Prostaglandin biosynthesis in the human fetal adrenal gland: regulation by glucocorticosteroids. (1982) (17)
- Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots. (2019) (17)
- Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively (2007) (16)
- Cholesterol hydroxylation in the adrenal cortex and liver. (1971) (16)
- Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction. (2016) (16)
- Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice (2017) (16)
- Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse. (2005) (15)
- The role of cyclic adenosine 3',5'-monophosphate in cholesterol metabolism and steroidogenesis by the human fetal adrenal gland. (1981) (15)
- Regulation of the synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the bovine ovary in vivo and in vitro. (1987) (15)
- Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal. (1976) (15)
- Molecular aspects of the biosynthesis of adrenal steroids. (1976) (15)
- Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes (1992) (15)
- CHAPTER 8 – Adrenodoxin: An Iron-Sulfur Protein of Adrenal Cortex Mitochondria (1973) (14)
- Erratum: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription (Journal of Clinical Endocrinology and Metabolism (1993) 77 (1622-1 (1994) (14)
- Obesity, aromatase and breast cancer (2011) (14)
- Interaction of androgens with the adrenal mitochondrial cytochrome system. The influence of androgen treatment on the levels of cytochrome in rat adrenal cortical mitochondria and on substrate-induced spectral changes. (1970) (14)
- Regulation of CYP11A gene expression in bovine ovarian granulosa cells in primary culture by cAMP and phorbol esters is conferred by a common cis-acting element (1993) (14)
- Metabolism of high density lipoprotein by human fetal adrenal tissue. (1980) (14)
- Regulation of low-density lipoprotein receptors in cultured bovine adrenocortical cells. (1982) (14)
- Rat adrenal 5 alpha-reductase mRNA content and enzyme activity are sex hormone dependent. (1991) (13)
- Regulation of aromatase expression in the ovary and placenta: a comparison between two species (1997) (13)
- Effects of Conditioned Medium from Different Cultured Cell Types on Aromatase Expression in Adipose Stromal Cells (1995) (13)
- Involvement of early growth response factors in TNFα-induced aromatase expression in breast adipose (2013) (13)
- Minireview: aromatase and the regulation of estrogen biosynthesis--some new perspectives. (2001) (13)
- Molecular basis of 17α-hydroxylase/17,20-lyase deficiency (1992) (13)
- Myocardial and cardiomyocyte stress resilience is enhanced in aromatase-deficient female mouse hearts through CaMKIIδ activation. (2015) (13)
- Genetic mutations resulting in loss of aromatase activity in humans and mice. (2000) (13)
- Synthesis of cholesterol in the human fetus: 3-hydroxy-3-methylglutaryl coenzyme A reductase activity of liver microsomes. (1981) (13)
- Regulation of CYP11A (P450SCC) and CYP17 (P450(17) alpha) gene expression in bovine luteal cells in primary culture. (1991) (12)
- Cholesterol metabolism in human cancer cells in monolayer culture. V. The effect of progesterone on the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by low density lipoprotein. (1981) (12)
- Factors affecting cholesterol esterase and cholesterol side-chain-cleavage activities in rat adrenal. (1972) (12)
- The regulation of oestrogen biosynthesis in human adipose tissue (1989) (12)
- 17α-Hydroxylase gene expression in the bovine ovary: Mechanisms regulating expression differ from those in adrenal cells (1996) (12)
- Binding of high density lipoprotein to human fetal adrenal membrane fractions. (1981) (12)
- Human anencephalic adrenal tissue: low density lipoprotein metabolism and cholesterol synthesis. (1981) (12)
- Aromatase deficiency inhibits the permeability transition in mouse liver mitochondria. (2010) (12)
- Sex and fat--can one factor handle both? (2005) (11)
- Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer (2012) (11)
- Regulation of steroid hydroxylase gene expression. (1988) (11)
- Regulation of aromatase in estrogen-producing cells. (1987) (11)
- Cholesterol synthesis by human fetal hepatocytes: effect of lipoproteins. (1984) (11)
- Regulation of human aromatase cytochrome P450 gene expression (1992) (11)
- Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain (2008) (10)
- Adenylate cyclase activity in neocortex and fetal zone membrane fractions of the human fetal adrenal gland. (1985) (10)
- Brenner tumor of the ovary: immunoanalysis of steroidogenic enzymes in 23 cases. (1989) (9)
- Transcription of the bovine adrenodoxin gene produces two species of mRNA of which only one is translated into adrenodoxin. (1988) (9)
- Erratum: p53: Protection against tumor growth beyond effects on cell cycle and apoptosis (Cancer Res (2015) 75 (5001-5007)) (2016) (9)
- Regulation of steroid hydroxylase gene expression and steroid hormone biosynthesis. (1990) (9)
- Oestrogen Replacement in vivo Rescues the Dysfunction of Pituitary Somatotropes in Ovariectomised Aromatase Knockout Mice (2005) (9)
- Inverse relationship between ovarian aromatase cytochrome P450 and 5 alpha-reductase enzyme activities and mRNA levels during the estrous cycle in the rat. (1992) (8)
- Steroidogenic refractoriness of bovine adrenocortical cells to dibutyryl cyclic AMP (1983) (8)
- Tissue-Specific Regulation of Aromatase Cytochrome P450 (CYP19) Expression (1993) (7)
- Regulation of the synthesis of aromatase cytochrome P-450 in human adipose stromal and ovarian granulosa cells (1987) (7)
- Regulation of Cytochrome P‐45017α Activity and Synthesis in Bovine Adrenocortical Cells a (1985) (7)
- Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency. (1987) (7)
- Expression of neural 5 alpha-reductase messenger ribonucleic acid: comparison to 5 alpha-reductase activity during prenatal development in the rat. (1990) (7)
- Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a stop codon in the N-terminal region of 17 alpha-hydroxylase cytochrome P-450. (1988) (7)
- Complexity of steroid hydroxylase gent expression in the adrenal cortex A microcosm of regulated transcription (1989) (7)
- Cellular mechanisms involved in the acute and chronic actions of ACTH (1985) (6)
- Expression of genes encoding steroidogenic enzymes in the bovine corpus luteum. (2019) (6)
- Inhibition of adenylate cyclase activity in human fat cells by alpha-adrenergic agonists. (1982) (6)
- ISGE statement on oral emergency contraception (2014) (6)
- The heterologous expression of the cytochromes P450: a new approach for the study of enzyme activities and regulation. (1991) (6)
- Immunolocalisation of aromatase regulators liver kinase B1, phosphorylated AMP-activated protein kinase and cAMP response element-binding protein-regulated transcription co-activators in the human testis. (2017) (6)
- Sex, fat and breast cancer (2009) (5)
- Developmental Regulation of P-45017α Gene Expression in Fetal Bovine Adrenal (1989) (5)
- Bovine Adrenocortical Cytochrome P-45OI7, REGULATION OF GENE EXPRESSION BY ACTH AND ELUCIDATION OF PRIMARY SEQUENCE* (2001) (5)
- Estrogens, Obesity, Inflammation, and Breast Cancer—What Is the Link? (2015) (5)
- The Cytochrome P-450 Superfamily: Impact on Biology and Medicine (1990) (5)
- Combined 17 alpha-hydroxylase/17,20-lyase deficiency due to a 7-basepair duplication in the N-terminal region of the cytochrome P45017 alpha (CYP17) gene. (1990) (5)
- The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice (2009) (5)
- Structural characterization of the bovine CYP17 (17 alpha-hydroxylase) gene. (1989) (5)
- The role of adipose tissue in estrogen biosynthesis in the human (1990) (4)
- Lack of aromatase improves cell-mediated immune response after burn. (2006) (4)
- Expression of P-450 enzyme activities in heterologous cells by transfection. (1989) (4)
- Neuroendocrine Inherited or Induced Aromatase Enzyme Deficits (2012) (4)
- Effect of prostaglandins on steroid secretion by human fetal adrenal tissue (1983) (4)
- Cholesterol metabolism in cancer cells in monolayer culture--IV. regulation of cholesteryl ester synthesis. (1982) (4)
- A doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse (2012) (4)
- Hormonal regulation of the xenobiotic metabolizing enzymes (1988) (4)
- Cytochrome P-450 activity in sheep corpora lutea during the oestrous cycle. (1973) (4)
- Substrate-induced efflux of anions from bovine adrenal cortex mitochondria and its relationship to steroidogenesis. (1969) (4)
- Failure of contraceptive steroids to modify human chorionic gonadotrophin secretion by hydatidiform mole tissue and choriocarcinoma cells in culture (1981) (4)
- Induction of synthesis of steroidogenic enzymes by corticotropin in bovine adrenocortical cells in culture. (1983) (3)
- Molecular cloning of steroid hydroxylases. (1984) (3)
- Prostaglandin secretion by the neocortex and fetal zones of the human fetal adrenal gland. (1983) (3)
- Lessons from the ArKO mouse (2008) (3)
- The Link Between Obesity and Breast Cancer Risk: Epidemiological Evidence (2014) (3)
- Tibolone was associated with an increase in 7 alpha-methyl-ethinylestradiol. (2003) (3)
- Correction: p53: Protection against Tumor Growth beyond Effects on Cell Cycle and Apoptosis. (2016) (3)
- The Aromatase Reaction (1996) (3)
- Lipoproteins and the regulation of steroidogenesis. (1985) (2)
- Effect of ACTH on the stability of mRNAs encoding bovine adrenocortical P-450scc, P-45011 beta, P-45017 alpha, P-450C21 and adrenodoxin. (1989) (2)
- Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism (2013) (2)
- Developmental regulation of P-45017 alpha gene expression in fetal bovine adrenal. (1989) (2)
- Abstract S5-6: Steroid Hormone Regulation of Mammary Stem Cell Function (2010) (2)
- Peroxisome Proliferator-activated Receptorg Ligands Inhibit Estrogen Biosynthesis in Human Breast Adipose Tissue: Possible Implications for Breast Cancer Therapy (2000) (2)
- Induction of 17 alpha-hydroxylase (cytochrome P-450(17)alpha) activity by adrenocorticotropin in bovine adrenocortical cells maintained in monolayer culture. (1983) (2)
- Mechanisms of induction of endogenous substrate oxidation (1985) (2)
- Regulation of aromatase P450 gene expression in human placenta (1996) (2)
- Steroidogenic capacity in the adrenal cortex and its regulation. (1990) (2)
- Role of estrogens in the male reproductive tract. (2004) (2)
- Low density lipoprotein receptors in adrenal tissue of a human anencephalic fetus. (1982) (2)
- The aromatase enzyme: from cloning to cancer. (1990) (2)
- Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice. (2017) (2)
- HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma (2013) (1)
- Synergistic induction of aryl hydrocarbon hydroxylase (AHH) activity in human fetal hepatocytes by polycyclic hydrocarbons and dexamethasone (1984) (1)
- 1061 AROMATASE DEFICIENCY INCREASES FUNCTIONAL RESPONSE TO Ca2+ LOADING CONDITIONS IN FEMALE CARDIOMYOCYTES (2012) (1)
- Aromatase research and its clinical significance Znaczenie kliniczne badań nad aromatazą (2010) (1)
- Metformin Inhibits Aromatase Expression in Primary Human Breast Adipose Stromal Cells. (2009) (1)
- 158. Effects of phytoestrogens on the ovarian and pituitary phenotypes of oestrogen deficient female aromatase knockout mice (2004) (1)
- Obesity and Breast Cancer (2014) (1)
- Cholesterol hydroxylation in the adrenal cortex and liver. (1972) (1)
- Lessons from the ArKO mouse: Aromatase Inhibitors (2006) (1)
- Letter to the editor (multiple letters) (2000) (1)
- Aromatase cytochrome P-450: Preparation of polyclonal and monoclonal antibodies and a cDNA insert (1987) (1)
- Estrogen Deficient Male Mice Develop Compulsive (2007) (1)
- Induction of synthesis of bovine adrenocortical cytochromes P-450scc, P-45011 beta, P-450C21, and adrenodoxin by prostaglandins E2 and F2 alpha and cholera toxin. (1984) (1)
- Characterization of the Promoter / Regulatory Region of the Bovine CYPllA ( P-450 , , , ) Gene (2001) (1)
- A Selective Estrogen Receptor Alpha Agonist Ameliorates Hepatic Steatosis in the Male (2011) (1)
- Dysregulated metabolism and the regulation of aromatase in breast adipose stromal cells in obesity and cancer (2012) (1)
- Inhibins, Activins, and Estrogens: Roles in the Ovulatory Sequence (2000) (1)
- Transcriptional regulation of the CYP17 gene in the bovine ovary before and after luteinization (1998) (0)
- IS-57 Somatic Cells within Abnormal Follicles of the Female ArKO Mouse Exhibit Characteristics of Adult Sertoli Cells (2001) (0)
- Metabolic Syndrome Alters Expression Levels of Metabolic Disease Risk Loci Genes (2010) (0)
- 75. The aromatase knockout (ArKO) mouse as a model to study the oestrogenic actions of tibolone (2003) (0)
- Regulation of Genes Encoding Steroidogenic Enzymes in the Ovary (1991) (0)
- A novel compound heterozigous mutation of the aromatase gene in an adult manl (2006) (0)
- Studies of the hydroxylation of cholesterol in endocrine tissues (1967) (0)
- Fat, sex hormones and breast cancer (2011) (0)
- Estrogen, telomerase, ovarian againg and cancer (2009) (0)
- Lack of estrogen in aromatase deficient mice results in hypertension, reduced baroreflex sensitivity and response to stress. (2007) (0)
- Isolation and characterization of a complementary DNA specific for human aromatase-system cytochrome P-450 mRNA ( estrogen biosynthesis / regulation ) (0)
- Abstract A18: Inflaming breast cancer development: Expression of aromatase is increased by TNFα via the early growth response genes (2011) (0)
- Aromatase and Estrogen Insufficiency (2003) (0)
- Pharmacotherapy: Disparate bedfellows in a lasting drug union? (2013) (0)
- CASE SEMINAR Expression in a Feminizing Adrenocortical (1996) (0)
- Investigations into the epigenetic mechanisms regulating the prostanoid receptor EP2 in estrogen dependent breast cancer (2012) (0)
- Dysmetabolic Syndrome in a new case of male aromatase deficiency (AD): effects of testosterone (TT) and estradiol treatment (ET) (2003) (0)
- Sex, Fat, and Ovarian Cancer. (2008) (0)
- Lipoprotein regulation of progesterone secretion by choriocarcinoma cells in culture [proceedings]. (1979) (0)
- ACTH induction of cytochrome P-450(SCC) in bovine adrenal cortical cell cultures (1981) (0)
- ACTH INDUCTION OF CHOLESTEROL SIDE CHAIN CLEAVAGE CYTOCHROME (P–450scc) IN PRIMARY CULTURES OF ADULT BOVINE ADRENAL CORTICAL CELLS (1981) (0)
- Edinburgh Research Explorer SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24(+) CD49f(hi) Mammary Stem Cell-Enriched Compartment (2018) (0)
- Characterization and role of α-adrenergic receptors in human adipocytes (1981) (0)
- Electron-Paramagnetic-Resonance Studies of Cytochrome P-450 in Whole Rat Adrenal Glands (1975) (0)
- The effects of targeted deletion of the aromatase enzyme on prostatic contractile responses to noradrenaline in mice. (2007) (0)
- Breast cancer and metastasis free survival are effected by PRMT2 and Rory; Expression: Understanding the Role of DNA Repair (2014) (0)
- Estrogens, Adiposity and the Menopause (2014) (0)
- Aromatase and metabolic regulation: Molecular pathogenesis and therapy of pituitary disease (2006) (0)
- TNF[alpha] induced aromatase expression is mediated by the Early Growth Response transcription factors in breast adipose (2012) (0)
- Effects of ACTH and LDL on the transcription of cytochrome P-450scc mRNA (1985) (0)
- Estrogens and the brain. Preface. (2009) (0)
- Brain phenotype of the aromatase knockout mouse (2003) (0)
- ErratumSex and fat—Can one factor handle both? (2006) (0)
- Proceedings: Effect of respiration-supported calcium uptake on pregnenolone formation and spectral changes of cytochrome P450 in rat adrenal mitochondria. (1975) (0)
- Estrogen synthesis genes: P-450 Aromatase (2003) (0)
- Stem Cell Repor ts SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24 + CD49f hi Mammary Stem Cell-Enriched Compar tment (0)
- Characterising a novel mouse model of the metabolic syndrome (2009) (0)
- Diminished Contracture and Improved Post-Ischemic Functional Recovery in the Aromatase Knockout Mouse Heart (2010) (0)
- Adipose-Derived and Obesity-Related Factors and Breast Cancer (2014) (0)
- A doxycycline-inducible, tissue-specific aromatase-expressing transgenic mouse (2011) (0)
- Aromatase Deficiency Influences the Acute Response to Myocardial Ischaemic Insult in Female Mice—A Matter of Local Sex Steroid Balance? (2011) (0)
- 2. Regulation of Estrogen Receptor Activity and Aromatase Expression: Roles of Selective Estrogen Receptor Modulators and Metabolic Factors (2012) (0)
- Aromatase, Nuclear Receptors, Adipose Tissue, And Breast Cancer (2002) (0)
- of CYPIIA and CYP17 Messenger RNAs in Bovine Adrenocortical Cells (1993) (0)
- Adrenodoxin Biosynthesis by Bovine Adrenal Cells in (1982) (0)
- Death in Vascular Smooth Muscle Cells : Insights From the Aromatase-Knockout Mouse Endogenous Estrogen Deficiency Reduces Proliferation and Enhances Apoptosis-Related (2004) (0)
- Catechol-O-methyltransferase activity in erythrocytes of persons with severe thermal injury. (1983) (0)
- Alendronate and long-term testosterone treatment and BMD in an aromatase-deficient man (2001) (0)
- Metabolism in Cancer Cells in Monolayer Culture Effect of Cell Density and Confluency on Cholesterol Updated (2006) (0)
- Epigenetic Control of Estrogen Synthesis in Human Preadipocytes and Breast Cancer Cells. (2009) (0)
- The effects of estrogen deficiency on bone mineral density and body composition in aging female mice (2000) (0)
- Chapter 5 Tissue-specific expression of the CYP19 (aromatase) gene (1998) (0)
- Therapy Aimed at Breaking the Linkage Between Obesity and Breast Cancer (2014) (0)
- Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin : Evidence for a previously unidentified COOH-terminal peptide ( iron-sulfur proteins / adrenocortical steroidogenesis / mitochondrial biogenesis / nucleotide sequencing / regulation of gene expression ) (0)
- Regulation of cytochrome P-450(17)alpha activity and synthesis in bovine adrenocortical cells. (1985) (0)
- Regulation of prostaglandin biosynthesis in the human-fetal adrenal by glucocorticosteroids (1982) (0)
- Contents (2014) (0)
- Regulation of prostaglandin (PG) formation in human adipose stromal cells by dexamethasone(DEX) and dibutyryl-cyclic-AMP (BU2CAMP) - A role for lipomodulin (1983) (0)
- Session 54: New findings in reproductive oncology (2013) (0)
- EFFECT OF CALCIUM ON PREGNENOLONE FORMATION AND CYTOCHROME P-450 IN RAT ADRENAL MITOCHONDRIA (1976) (0)
- Inhibition of the lipolytic action of p-adrenergic agonists in human adipocytes by a-adrenergic agonists (2002) (0)
- Unchanged prostate contractility in the aromatase knockout (ArKO) mouse: comparison between wildtype, heterozygous and mutant mice (2006) (0)
- A novel compound heterozygous mutation of the aromatase gene in an adult man: a reinforced evidence on the relationships among congenital estrogen deficiency, adiposity and the metabolic syndrome (2007) (0)
- 41. Effect of prostaglandins on steroid secretion by human fetal adrenal tissue (1982) (0)
- 161. Measurement of total testosterone in women: comparison of a direct radioimmunoassay versus radioimmunoassay after organic solvent extraction and celite partition column chromotography (2004) (0)
- Quantitation of aromatase cytochrome P450 mRNA levels in human breast tumours, using a comparative PCR technique (1992) (0)
- Comprar Obesity and Breast Cancer. The Role of Dysregulated Estrogen Metabolism Series: SpringerBriefs in Cancer Research | K. Brown | 9781489980014 | Springer (2014) (0)
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What Schools Are Affiliated With Evan R. Simpson?
Evan R. Simpson is affiliated with the following schools:
