Elliott N. Shaw
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Elliott N. Shawchemistry Degrees
Chemistry
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Analytical Chemistry
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Chemistry
Elliott N. Shaw's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry Stanford University
Why Is Elliott N. Shaw Influential?
(Suggest an Edit or Addition)Elliott N. Shaw's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin. (1967) (733)
- Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin‐like endoprotease. (1992) (626)
- Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60 (1992) (591)
- A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS. (1954) (590)
- Direct evidence for the presence of histidine in the active center of chymotrypsin. (1963) (536)
- Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine* (1965) (476)
- [2] Titration of trypsin, plasmin, and thrombin with p-nitrophenyl p′-guanidinobenzoate HCl☆ (1970) (414)
- Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes. (1969) (358)
- D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin. (1979) (280)
- STUDIES ON THE ACTIVE CENTER OF TRYPSIN. THE BINDING OF AMIDINES AND GUANIDINES AS MODELS OF THE SUBSTRATE SIDE CHAIN. (1965) (247)
- Chromatography of trypsin and its derivatives. Characterization of a new active form of bovine trypsin. (1968) (223)
- Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases. (1981) (174)
- Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones. (1994) (170)
- Some Neurophysiological Aspects of Serotonin (1954) (161)
- Thiobenzyl benzyloxycarbonyl-L-lysinate, substrate for a sensitive colorimetric assay for trypsin-like enzymes. (1979) (152)
- Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone. (1981) (135)
- Analogs of Aspergillic Acid. IV. Substituted 2-Bromopyridine-N-oxides and Their Conversion to Cyclic Thiohydroxamic Acids1 (1950) (123)
- The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B. (1988) (113)
- Cysteinyl proteinases and their selective inactivation. (1990) (109)
- Cofactor dependence of factor Xa incorporation into the prothrombinase complex. (1981) (106)
- Thrombocytin, a serine protease from Bothrops atrox venom. 1. Purification and characterization of the enzyme. (1979) (94)
- Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion. (1969) (94)
- The Purification of Thrombin and Isolation of a Peptide Containing the Active Center Histidine (1971) (83)
- A new method for labelling the active center of chymotrypsin. (1962) (81)
- Human plasma kallikrein. Purification and preliminary characterization. (1974) (80)
- A synthesis of protoanemonin; the tautomerism of acetylacrylic acid and of penicillic acid. (1946) (79)
- Rapid inactivation of cathepsin L by Z-Phe-PheCHN2 and Z-Phe-AlaCHN2 (1981) (78)
- Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2 (1994) (75)
- Some serotoninlike activities of lysergic acid diethylamide. (1956) (74)
- Kallikrein-Like Activity Of Crotalase, A Snake Venom Enzyme Which Clots Fibrinogen (1982) (74)
- THE IDENTIFICATION OF THE HISTIDINE RESIDUE AT THE ACTIVE CENTER OF CHYMOTRYPSIN. (1965) (72)
- The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor. (1989) (68)
- The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases. (1986) (67)
- Characterisation of a cysteine protease from bloodstream forms of Trypanosoma congolense. (1992) (66)
- [80] Site-specific reagents for chymotrypsin and trypsin (1967) (65)
- Yohimbine and ergot alkaloids as naturally occurring antimetabolites of serotonin. (1953) (62)
- Analogs of aspergillic acid; the tautomerism of the hydroxypyridine-N-oxides. (1949) (60)
- Further observations on substrate-derived chloromethyl ketones that inactivate trypsin. (1970) (59)
- 2 Chemical Modification by Active-Site-Directed Reagents* (1970) (58)
- Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein. (1978) (58)
- The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. (1993) (56)
- In vivo studies of a synthetic inhibitor of thrombin. (1982) (55)
- Active center differences between cathepsins L and B: The S1 binding region (1988) (55)
- Specific labeling of cysteine proteinases in pathogenic and nonpathogenic Entamoeba histolytica (1990) (52)
- The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases. (1980) (52)
- The specific inactivation of trypsin by ethyl p-guanidinobenzoate. (1967) (51)
- An Active Center Histidine Peptide of α-Chymotrypsin (1964) (50)
- Analogs of aspergillic acid; various antibacterial heterocyclic hydroxamic acids. (1949) (49)
- Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases. (1994) (46)
- Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone. (1974) (45)
- The use of isoxazolium salts for carboxyl group modification in proteins. Trypsin. (1969) (45)
- Inactivation of calpain by peptidyl fluoromethyl ketones. (1992) (44)
- Diazomethyl ketone substrate derivatives as active-site-directed inhibitors of thiol proteases. Papain. (1977) (44)
- The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B. (1987) (42)
- The reactivity of His-57 in chymotrypsin to alkylation. (1971) (42)
- The affinity‐labelling of cathepsin s with peptidyl diazomethyl ketones (1993) (42)
- Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis. (1991) (40)
- A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones. (1979) (39)
- Identification of the histidine residue at the active center of trypsin labelled by TLCK. (1967) (39)
- Lysis of trypanosomes by peptidyl fluoromethyl ketones. (1990) (37)
- The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketone. (1981) (36)
- An exploration of the primary specificity site of cathepsin B. (1983) (36)
- Active site mapping of human and rat urinary kallikreins by peptidyl chloromethyl ketones. (1980) (35)
- A new and convenient synthesis of 4-amino-5-imidazolecarboxamide. (1949) (35)
- The Synthesis of Tryptamines Related to Serotonin (1955) (35)
- The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketone. (1979) (35)
- 5-Amino-4-imidazolecarboxamide Riboside from Inosine. Ring-opening Reactions of Purine Nucleosides (1958) (34)
- Some imidazo-1,2,3,-triazines and their biological relationship to the purines. (1951) (33)
- The essentiality of histidine in the catalytic action of subtilisin. Covalent modification by a specific reagent. (1968) (33)
- The Synthesis of 6-Hydroxymethylypteridines (1964) (33)
- Studies on the active center of trypsin. Further characterization of the hydrophobic binding site. (1967) (33)
- 4-Benzyl-2,6-dimethylpyridine, 1-benzylisoquinoline, 9-benzylacridine, and certain relatives. (1948) (33)
- Antimetabolites of serotonin. (1953) (32)
- Imidazo-1,2,3-triazines as substrates and inhibitors for xanthine oxidase. (1952) (31)
- Inhibition of intraerythrocytic development of Plasmodium falciparum by proteinase inhibitors (1990) (29)
- Leishmania amazonensis: involvement of cysteine proteinases in the killing of isolated amastigotes by L-leucine methyl ester. (1989) (29)
- Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors. (1991) (28)
- The specificity of cathepsin B. (1981) (28)
- Evaluation of inhibitor constants and alkylation rates for a series of thrombin affinity labels. (1985) (27)
- Peptidyl sulfonium salts. A new class of protease inhibitors. (1988) (27)
- Inactivation of cathepsin B1 by diazomethyl ketones. (1977) (27)
- Affinity labelling of the Ca(2+)-activated neutral proteinase (calpain) in intact human platelets. (1993) (27)
- The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents. (1989) (27)
- A comparison of deacylation rates of para-substituted benzoyl-trypsins and chymotrypsins. (1972) (27)
- Substrate specificity and inhibitor sensitivity of a trypanosomatid alkaline peptidase. (1990) (26)
- Functional sites of glia-derived nexin (GDN): importance of the site reacting with the protease. (1990) (26)
- Isolation of a Chinese Hamster Ovary Cell Clone Possessing Decreased μ-Calpain Content and a Reduced Proliferative Growth Rate* (1996) (26)
- The Synthesis of Nitro- and Aminoindoles Analogous to Serotonin (1953) (25)
- Inactivation of thiol proteases with peptidyl diazomethyl ketones. (1981) (25)
- Differentiation between receptors for serotonin and tryptamine by means of the exquisite specificity of antimetabolites. (1957) (25)
- The modification of essential carboxylic acid side chains of trypsin. (1969) (25)
- Synthesis and properties of peptidyl derivatives of arginylfluoromethanes. (1988) (25)
- SOME ANTIMETABOLITES OF SEROTONIN AND THEIR POSSIBLE APPLICATION TO THE TREATMENT OF HYPERTENSION (1952) (24)
- Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes. (1993) (24)
- Antiserotonins in hypertension and the antimetabolite approach to chemotherapy. (1956) (24)
- Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone. (1979) (24)
- The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. (1989) (23)
- [58] Site-specific reagents for chymotrypsin, trypsin, and other serine proteases. (1972) (23)
- Isolation and characterization of a trypsin-like serine proteinase from the membranes of Walker 256 carcino-sarcoma cells. (1983) (22)
- Inactivation of boar acrosin by peptidyl-arginyl-chloromethanes. Comparison of the reactivity of acrosin, trypsin and thrombin. (1978) (22)
- Rearrangements in the Displacement of Chloride from 2-Chloro-7-methyladenine (1962) (22)
- The specificity of macrophage elastase on the insulin B-chain. (1981) (21)
- Synthesis and properties of Cbz-Phe-Arg-CHN2 (benzyloxycarbonylphenylalanylarginyldiazomethane) as a proteinase inhibitor. (1988) (21)
- A Convenient Preparation of 5-Amino-4-imidazolecarboxamide Riboside. Ring Opening of N1-p-Toluenesulfonyl-inosine (1959) (21)
- Methylserotonins as potent antimetabolites of serotonin active both in vitro and in vivo. (1956) (21)
- Pharmacological properties of some antimetabolites of serotonin having unusually high activity on isolated tissues. (1954) (20)
- Isolation and characterization of the alkylated histidine from TLCK inhibited trypsin. (1965) (20)
- Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification. (1991) (20)
- Inhibition of endoproteolytic cleavage of cytomegalovirus (HCMV) glycoprotein B by palmitoyl-peptidyl-chloromethyl ketone. (1990) (17)
- Inactivation of cathepsin B by active site-directed disulfide exchange. Application in covalent affinity chromatography. (1983) (17)
- An antiserotonin which is active when fed. (1953) (17)
- A prolyl endopeptidase from murine macrophages, its assay and specific inactivation. (1983) (17)
- Active-site-directed phenacyl halides inhibitory to trypsin. (1971) (17)
- Heterogeneity in late-onset metachromatic leukodystrophy. Effect of inhibitors of cysteine proteinases. (1986) (16)
- The biosynthesis of 2-amino-4-hydroxy-6-substituted pteridines. The origin of carbon atoms 6, 7, and 9 of folic acid. (1966) (15)
- Inhibition of cancer procoagulant by peptidyl diazomethyl ketones and peptidyl sulfonium salts. (1989) (15)
- Peptidyl fluoromethyl ketones as thiol protease inhibitors. (1986) (15)
- Aromatic esters which inhibit plasmin or thrombin by formation of relatively stable acyl enzymes. (1973) (14)
- The properties of peptidyl diazoethanes and chloroethanes as protease inactivators. (1989) (14)
- Identification of histidine 64 in the active site of subtilisin. (1968) (13)
- A METHOD FOR INCREASING BRAIN SEROTONIN WITHOUT INCURRING SOME OF THE PERIPHERAL EFFECTS OF THE HORMONE. (1957) (13)
- A Chemical Preparation of 5-Amino-4-imidazolecarboxamide Ribotide (1961) (13)
- Cysteine protease characteristics of the proteoglycanase activity from normal and pseudoxanthoma elasticum (PXE) fibroblasts. (1983) (13)
- Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase. (1992) (12)
- Rapid interaction of cathepsin L by Z-Phe-PheCHN12 and Z-Phe-AlaCHN2. (1981) (12)
- The Preparation and Properties of Certain Acetylenic Tertiary Carbinols (1941) (12)
- The inhibition of crotalase, a thrombin-like snake venom enzyme, by several peptide chloromethyl ketone derivatives. (1981) (12)
- Differences in active center reactivity of trypsin homologs. Specific inactivation of thrombin by nitrophenyl p-amidinophenylmethanesulfonate. (1974) (11)
- Studies on the Active Center of Trypsin (2003) (11)
- Observations on the Cyclization of a Substituted α-Formamidoamidine to Aminoimidazolecarboxamide Derivatives1 (1965) (11)
- The reaction of β-propiolactone with inosine 5′-phosphate: The preparation of N-(5-amino-1-β-d-ribofuranosyl-imidazole-4-carbonyl)-β-alanine 5′-phosphate (1966) (11)
- Iodination of peptidyl chloromethyl ketones for protease affinity labels. (1988) (11)
- Inactivation of trypsin-like proteases by active-site-directed sulfonylation. Ability of the departing group to confer selectivity. (1976) (11)
- Synthesis of lysine-containing sulphonium salts and their properties as proteinase inhibitors. (1988) (11)
- Progress in Designing Small Inhibitors which Discriminate among Trypsin-Like Enzymes (1974) (11)
- 13C high-resolution nuclear magnetic resonance studies of enzyme-substrate reactions at equilibrium. Substrate studies of chymotrypsin-N-acetyltyrosine semicarbazide complexes. (1974) (10)
- The role of pyrimidines in the biogenesis of pteridines. (1963) (9)
- Indole Carboxamidines and Aminomethylindoles as Antimetabolites of Serotonin (1957) (9)
- Serotonin Analogs. The Synthesis of 5-Dimethylaminoindoles (1954) (9)
- Leishmania amazonensis: specific labeling of amastigote cysteine proteinases by radioiodinated N-benzyloxycarbonyl-tyrosyl-alanyl diazomethane. (1991) (9)
- Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length. (1978) (9)
- Synthesis and properties of cyclic peptides containing the activation site of plasminogen. (2009) (9)
- Benzyldimethylbufotenin, a Powerful Antimetabolite of Serotonin (1956) (9)
- The selective inactivation of thiol proteasesin vitro andin vivo (1984) (9)
- Intra-acrosomal inhibition of boar acrosin by synthetic proteinase inhibitors. (1983) (8)
- Detection of peptidases in Trypanosoma cruzi epimastigotes using chromogenic and fluorogenic substrates (1992) (8)
- Synthesis of oligopeptide chloromethanes to investigate extended binding regions of proteinases: application to the interaction of fibrinogen with thrombin. (1993) (7)
- The chemical degradation of folic acid. Photolysis of 2,4,7-trihydroxypteridine. (1966) (7)
- Analogs of Aspergillic Acid. III. Synthesis of Cyclic Hydroxamic Acids with a Five-membered Ring (1949) (7)
- Improved synthetic inactivators of plasmin. (1987) (7)
- Inhibition of cysteine proteinase activity by Z-Phe-Phe-diazomethane and of aspartic proteinase activity by pepstatin in different organs from some animals and isolated cells from rat liver. (1982) (7)
- Active-site-directed alkylation of chymotrypsin by reagents utilizing various departing groups. (1976) (6)
- Synthesis and Demonstration of Antiserotonin Activity of 1-Benzyl-2-methyl-5-hydroxytryptamine (BAS-phenol) (1957) (6)
- Pseudoarginine: synthesis and properties of derivatives of delta-(1-imidazolyl)norvaline. (1990) (6)
- The synthesis and properties of peptidylmethylsulphonium salts with two cationic residues as potential inhibitors of prohormone processing. (1988) (6)
- Inactivation of trypsin-like proteases by depsipeptides of p-guanidinobenzoic acid. (1981) (6)
- AN ANTISEROTONIN WHICH IS ORALLY EFFECTIVE (1952) (5)
- Expression of an active cathepsin B-like protein Sm31 from Schistosoma mansoni in insect cells. (1992) (5)
- The Partial Reduction of Acetylenes to Olefins Using an Iron Catalyst. II. Enyne and Dienyne Reduction1 (1942) (5)
- THE BIOSYNTHESIS OF 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLPTERIDINE. (1964) (4)
- Modification of trypsin by a reactive intermediate generated from p-(N 3 ,S-dimethylisothiouronium)-benzoyl trypsin. (1971) (3)
- Additional peptidyl diazomethyl ketones, including biotinyl derivatives, which affinity-label calpain and related cysteinyl proteinases. (1992) (3)
- The Specificity Site of Trypsin (1970) (3)
- Tryptamine and Serotonin Receptors (1962) (3)
- Enkephalins Mediate Cholecystokinin-Induced Gallbladder Contraction in the Guinea Pig (1984) (3)
- The use of cysteine proteinase inhibitors as a possible antischistosomal approach (1994) (2)
- Peptidyl chloromethyl ketones and diazomethyl ketones as protease affinity labels (1981) (2)
- Synthesis of histidine-containing dipeptide affinity-labelling agents. Relative inactivation rates of cathepsins B and L. (2009) (1)
- Thrombin inhibitors based on peptidyl halomethanes with a long peptide sequence (1991) (1)
- INACTIVATION OF TRYPSIN-LIKE PROTEASES BY SULFONYLATION. VARIATION OF POSITIVELY CHARGED GROUP AND INHIBITOR LENGTH (1978) (1)
- Substrate specificity and inhibitor sensitivity of a Trypanosoma cruzi alkaline peptidase. (1990) (1)
- Leishmanicidal activity of amino acid and peptide esters: an update. (1988) (1)
- A novel mechanism ofinteraction withprolyl endopeptidase (1992) (0)
- ACTIVE-SITE-DIRECTED ALKYLATION OF CHYMOTRYPSIN BY REAGENTS UTILIZING VARIOUS DEPARTING GROUPS (1977) (0)
- Lysosomes of Leishmania Mexicana Sp. as Targets for Potential Therapeutic Agents (1992) (0)
- INACTIVATION OF TRYPSIN-LIKE PROTEASES BY DEPSIPEPTIDES OF P-GUANIDINOBENZOIC ACID (1981) (0)
- The reaction of beta-propiolactone with inosine 5'-phosphate. The preparation of N-(5-amino-I-beta-D-ribofuranosyl-imidazol-4-carbonyl)-beta-alanine 5-phosphate. (1966) (0)
- ADDITIONAL PEPTIDYL DIAZOMETHYL KETONES, INCLUDING BIOTINYL DERIVATIVES, RELATED CYSTEINYL PROTEINASES WHICH AFFINITY-LABEL CALPAIN AND (1993) (0)
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