Eugene Willard Gerner

Eugene Willard Gerner's AcademicInfluence.com Rankings

Biology

#12743

World Rank

#16239

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Biochemistry

#2203

World Rank

#2348

Historical Rank

biology Degrees

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Biology

Eugene Willard Gerner's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Eugene Willard Gerner's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Polyamines and cancer: old molecules, new understanding (2004) (979)
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial (2008) (460)
Polyamine-dependent gene expression (2003) (355)
Development of difluoromethylornithine (DFMO) as a chemoprevention agent. (1999) (333)
Heat shock proteins in thermotolerance and other cellular processes. (1987) (224)
Clinical hyperthermia: Results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy (1982) (220)
Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. (1998) (203)
A transient thermotolerant survival response produced by single thermal doses in HeLa cells. (1976) (197)
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene (2003) (182)
Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer* (2003) (142)
Hyperthermic potentiation. Biological aspects and applications to radiation therapy (1977) (138)
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. (1998) (130)
Cell cycle-specific activity of type I and type II cyclic adenosine 3':5'-monophosphate-dependent protein kinases in Chinese hamster ovary cells. (1976) (129)
Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man. (1977) (112)
Dose de-escalation chemoprevention trial of alpha-difluoromethylornithine in patients with colon polyps. (1994) (110)
The potential of localized heating as a adjunct to radiation therapy. (1975) (108)
Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts (1986) (105)
Efflux of the Natural Polyamine Spermidine Facilitated by the Bacillus subtilis Multidrug Transporter Blt* (1997) (101)
Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. (1997) (100)
A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma (2015) (98)
Cholesterol levels inversely reflect the thermal sensitivity of mammalian cells in culture (1980) (96)
Surrogate end-point biomarkers as measures of colon cancer risk and their use in cancer chemoprevention trials. (1997) (96)
APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse. (1999) (95)
Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. (2006) (93)
Effect of heating on lethality due to hyperthermia and selected chemotherapeutic drugs. (1982) (93)
Polyamine biosynthesis and accumulation during the G1 to S phase transition (1977) (89)
Selenomethionine Inhibits Growth and Suppresses Cyclooxygenase-2 (COX-2) Protein Expression in Human Colon Cancer Cell Lines (2002) (89)
Identification and Characterization of a Diamine Exporter in Colon Epithelial Cells* (2008) (87)
Endoscopic optical coherence tomography and laser‐induced fluorescence spectroscopy in a murine colon cancer model (2006) (86)
Survival and cell kinetics effects of adriamycin on mammalian cells. (1973) (84)
Targeting polyamines and inflammation for cancer prevention. (2011) (78)
The relationship between polyamine accumulation and DNA replication in synchronized Chinese hamster ovary cells after heat shock. (1977) (78)
The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial (2008) (77)
Combination Chemoprevention for Colon Cancer Targeting Polyamine Synthesis and Inflammation (2009) (75)
Development of a polyamine database for assessing dietary intake. (2007) (74)
Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa. (1993) (74)
FACTORS REGULATING MEMBRANE PERMEABILITY ALTER THERMAL RESISTANCE * (1980) (71)
Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy. (2006) (69)
Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. (2010) (67)
Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β‐catenin activity in colon cancer cells (2010) (66)
Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. (2013) (65)
Suppression of polyamine catabolism by activated Ki‐ras in human colon cancer cells (2004) (65)
Risk of Cardiovascular Events in a Randomized Placebo-Controlled, Double-Blind Trial of Difluoromethylornithine plus Sulindac for the Prevention of Sporadic Colorectal Adenomas (2009) (63)
Loss of intracellular putrescine pool-size regulation induces apoptosis. (1997) (62)
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. (1986) (60)
AMXT‐1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport (2013) (60)
Hypusine formation in protein by a two-step process in cell lysates. (1987) (60)
Ornithine decarboxylase and polyamine levels in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus. (1988) (58)
Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells. (2008) (57)
Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival (2007) (57)
Spermidine mediates degradation of ornithine decarboxylase by a non‐lysosomal, ubiquitin‐independent mechanism (1987) (57)
Correlation between amounts of cellular membrane components and sensitivity to hyperthermia in a variety of mammalian cell lines in culture. (1982) (56)
Reactive nitrogen species in colon carcinogenesis. (1999) (56)
Assessment of mutations in ki‐ras and p53 in colon cancers from azoxymethane‐ and dimethylhydrazine‐treated rats (1997) (56)
Enhancement of hyperthermia-induced cytotoxicity by polyamines. (1980) (55)
Rate of heating as a determinant of hyperthermic cytotoxicity. (1981) (54)
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer (2018) (54)
Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. (2003) (53)
Combination of 5-Fluorouracil and N1,N11-Diethylnorspermine Markedly Activates Spermidine/Spermine N1-Acetyltransferase Expression, Depletes Polyamines, and Synergistically Induces Apoptosis in Colon Carcinoma Cells* (2005) (50)
Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. (2000) (49)
Caveolin‐1 is a novel regulator of K‐RAS‐dependent migration in colon carcinogenesis (2013) (49)
Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas (2013) (49)
Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis. (1997) (48)
Role of c-Myc in intestinal tumorigenesis of the Apc min/+ mouse1 (2006) (48)
Polyamine contents in rectal and buccal mucosae in humans treated with oral difluoromethylornithine. (1992) (47)
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention (2007) (47)
Task-based imaging of colon cancer in the Apc(Min/+) mouse model. (2006) (47)
Unique dietary‐related mouse model of colitis (2006) (46)
Combination Chemoprevention of Intestinal Carcinogenesis in a Murine Model of Familial Adenomatous Polyposis (2008) (46)
Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. (2010) (46)
Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine. (2000) (46)
APC‐dependent regulation of ornithine decarboxylase in human colon tumor cells (2002) (45)
Characterization of a Diamine Exporter in Chinese Hamster Ovary Cells and Identification of Specific Polyamine Substrates* (1997) (45)
Spermidine acetylation in response to a variety of stresses in Escherichia coli. (1991) (45)
Cyclic AMP levels and types I and II cyclic AMP-dependent protein kinase activity in synchronized cells and in quiescent cultures stimulated to proliferate. (1978) (44)
Heat-inducible vectors for use in gene therapy (2000) (44)
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells (2008) (44)
Non‐histone protein synthesis during G1 phase and its relation to dna replication (1976) (42)
Heat shock stimulates polyamine oxidation by two distinct mechanisms in mammalian cell cultures. (1987) (42)
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. (2001) (42)
Polyamines as modifiers of genetic risk factors in human intestinal cancers. (2003) (41)
Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. (1999) (41)
Interaction of Hyperthermia with Radiations of Different Linear Energy Transfer (1977) (40)
Polyamines are oncometabolites that regulate the LIN28/let‐7 pathway in colorectal cancer cells (2014) (40)
The cell-cycle phase synthesis of non-histone proteins in mammalian cells. (1973) (40)
DFMO: targeted risk reduction therapy for colorectal neoplasia. (2011) (39)
Modification of Radiosensitivity of Biological Systems (1978) (39)
The chemopreventive agent α‐difluoromethylornithine blocks Ki‐ras–dependent tumor formation and specific gene expression in Caco‐2 cells (2004) (39)
Dietary polyamine intake and risk of colorectal adenomatous polyps. (2012) (39)
Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine. (1994) (39)
Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer (1995) (38)
Reversal of resistance to methotrexate by hyperthermia in Chinese hamster ovary cells. (1981) (38)
Influence of growth state on several thermal responses of EMT6/Az tumor cells in vitro. (1979) (37)
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation. (1986) (37)
Hydroxyurea treatment affects the G1 phase in next generation CHO cells. (1977) (37)
G1 specific increases in cyclic AMP levels and protein kinase activity in Chinese hamster ovary cells. (1976) (37)
Associations of a Polymorphism in the Ornithine Decarboxylase Gene with Colorectal Cancer Survival (2009) (36)
The role of NO synthases in arginine‐dependent small intestinal and colonic carcinogenesis (2006) (35)
Dietary Putrescine Reduces the Intestinal Anticarcinogenic Activity of Sulindac in a Murine Model of Familial Adenomatous Polyposis (2006) (35)
Thermal dose and time-temperature factors for biological responses to heat shock. (1987) (34)
Dose-rate dependence of heat radiosensitization. (1983) (33)
Dissociation of 68,000 Mr heat shock protein synthesis from thermotolerance expression in rat fibroblasts. (1984) (33)
Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography (2007) (32)
Longitudinal Assessment of Air Conduction Audiograms in a Phase III Clinical Trial of Difluoromethylornithine and Sulindac for Prevention of Sporadic Colorectal Adenomas (2008) (32)
Ex vivo optical coherence tomography and laser induced fluorescence spectroscopy imaging of murine gastrointestinal tract (2005) (32)
Polyamine-mediated post-transcriptional regulation of COX-2. (2002) (31)
Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. (2010) (31)
Components of Metabolic Syndrome and Metachronous Colorectal Neoplasia (2009) (30)
Polyamine regulation of heat-shock-induced spermidine N1-acetyltransferase activity. (1990) (30)
The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells. (2004) (29)
Sources of variability in estimating ornithine decarboxylase activity and polyamine contents in human colorectal mucosa. (1994) (29)
Mammalian cell survival response following irradiation with 4 MeV X rays or accelerated helium ions combined with hyperthermia. (1976) (28)
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. (2007) (28)
Delayed sensitization to heat by inhibitors of polyamine-biosynthetic enzymes. (1982) (27)
Effects of interstitial irradiation alone, or in combination with localized hyperthermia on the response of a mouse mammary tumor. (1978) (27)
The Untapped Potential of Genetically Engineered Mouse Models in Chemoprevention Research: Opportunities and Challenges (2008) (26)
Polyamine-mediated turnover of ornithine decarboxylase in Chinese-hamster ovary cells. (1986) (26)
Cancer Chemoprevention Locks onto a New Polyamine Metabolic Target (2010) (26)
Polyamine transport systems in mammalian cells and tissues. (2011) (26)
Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer (2009) (26)
Polyamines and polyamine biosynthesis in cells exposed to hyperthermia. (1983) (25)
Collateral sensitivity to methotrexate in cells resistant to adriamycin. (1979) (25)
Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention. (2009) (25)
Potentiation of radiation myelitis in rats by hyperthermia. (1976) (25)
Deoxycholate-Induced Colitis is Markedly Attenuated in Nos2 Knockout Mice in Association with Modulation of Gene Expression Profiles (2007) (24)
Bile acid activation of the gadd153 promoter and of p53-independent apoptosis: relevance to colon cancer. (1996) (23)
Heat shock-induced shedding of cell surface integrins in A549 human lung tumor cells in culture. (1994) (22)
Inhibition of ionizing radiation recovery processes in polyamine-depleted Chinese hamster cells. (1988) (22)
Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells. (2003) (21)
Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine. (2014) (21)
Evaluation of Difluoromethylornithine for the Chemoprevention of Barrett's Esophagus and Mucosal Dysplasia (2011) (21)
Current concepts in colorectal cancer prevention (2009) (20)
The effects of ionizing radiation on the kinetics of DNA replication in synchronized Chinese hamster ovary cells. (1974) (20)
Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. (2002) (19)
Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. (2007) (18)
Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives. (2002) (17)
Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells (2007) (17)
Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047. (2009) (16)
Dietary Polyamine Intake and Polyamines Measured in Urine (2014) (16)
Cytoplasmic and nuclear protein kinases during the cell cycle. (1977) (16)
Inactivation of IκB contributes to transcriptional activation of spermidine/spermine N(1)‐acetyltransferase (2006) (16)
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells. (2004) (16)
Phosphorylation of a high molecular weight DNA polymerase alpha. (1987) (16)
Increased susceptibility of cells to inducible apoptosis during growth from early to late log phase: an important caveat for in vitro apoptosis research. (2000) (15)
Polyamines: a dual role in the modulation of cellular sensitivity to heat. (1982) (15)
Effect of a-Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention (1998) (15)
Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells. (1993) (15)
DNA replication kinetics in X-irradiated chinese hamster ovary cells. (1977) (14)
Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli. (1996) (14)
Accumulation of heat shock protein 70 RNA and its relationship to protein synthesis after heat shock in mammalian cells. (1987) (14)
Separation of normal human bone marrow cells by counterflow centrifugal elutriation. I. Morphological analysis and subfractionation of neutrophilic granulocytes. (1979) (14)
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells. (1996) (13)
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines. (1986) (13)
Combining polyamine depletion with radiation therapy for rapidly dividing head and neck tumors: strategies for improved locoregional control. (1994) (13)
Defining the role of polyamines in colon carcinogenesis using mouse models (2011) (13)
Back to the Future: Mechanism-Based, Mutation-Specific Combination Chemoprevention with a Synthetic Lethality Approach (2011) (13)
Delta-type DNA polymerase characterized from Drosophila melanogaster embryos. (1992) (13)
Sensitization of Chinese Hamster Ovary Cells to Heat Shock by α-Difluoromethylornithine (1987) (12)
Preclinical models for chemoprevention of colon cancer. (2003) (12)
Polyamine biosynthesis inhibitors combined with systemic hyperthermia in cancer therapy. (1990) (12)
Hydroxyurea inhibits ODC induction, but not the G1 to S phase transition. (1979) (12)
Alteration of cellular adhesion by heat shock. (1990) (12)
Polyamine catabolism in rodent and human cells in culture. (1991) (11)
GSTΠ stimulates caveolin-1-regulated polyamine uptake via actin remodeling (2019) (10)
Effects of diethyldithiocarbamate and endogenous polyamine content on cellular responses to hydrogen peroxide cytotoxicity. (1989) (10)
Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. (2001) (9)
Molecular Biology of Cancer (2003) (9)
Altered polyamine metabolism in chinese hamster cells growing in a defined medium (1986) (8)
Amifostine: a tonic or toxin to myeloid progenitors. (2000) (8)
Chemoprevention in patients with genetic risk of colorectal cancers. (2012) (8)
Intermittent Dosing with Sulindac Provides Effective Colorectal Cancer Chemoprevention in the Azoxymethane-Treated Mouse Model (2017) (8)
Ornithine decarboxylase induction in cells stimulated to proliferate differs from that in continuously dividing cells. (1980) (8)
Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. (1993) (7)
Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma. (2008) (7)
Activation of ornithine decarboxylase in monolayer cells treated with trypsin (1985) (7)
Pharmacogenomics of the Polyamine Analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl] eicosane Tetrahydrochloride, CGC-11093, in the Colon Adenocarcinoma Cell Line HCT1161 (2006) (7)
Regulation of DNA replication by serum and the transforming function in cultured rat fibroblasts transformed by Rous sarcoma virus (1979) (7)
Sensitization to heat by the polyamines and their analogs. (1983) (6)
Role of dietary polyamines in a phase III clinical trial of DFMO and sulindac for prevention of metachronous colorectal adenomas. (2010) (6)
Ornithine decarboxylase production in vitro by using mouse cDNA. (1987) (6)
Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas (2012) (5)
Combined Benefit of Prediction and Treatment: A Criterion for Evaluating Clinical Prediction Models (2014) (5)
Hypusine modification in eukaryotic initiation factor 5A in rodent cells selected for resistance to growth inhibition by ornithine decarboxylase-inhibiting drugs. (1996) (5)
Clinical end points for developing pharmaceuticals to manage patients with a sporadic or genetic risk of colorectal cancer (2012) (5)
Regulation of the HIV1 long terminal repeat by mutant heat shock factor. (2003) (5)
Flavin-containing monooxygenase (2019) (5)
Interstitial thermoradiotherapy. (1982) (5)
Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography (2015) (5)
Ornithine decarboxylase (Odc)-1 gene polymorphism effects on baseline tissue polyamine levels and adenoma recurrence in a randomized phase III adenoma prevention trial of DFMO + sulindac versus placebo (2008) (5)
Analysis of the Length of S‐Phase Required to Show Sister Chromatid Differential Staining (1986) (4)
Polyamine Pools and Cancer Prevention (2006) (4)
A DNA Polymerase α-Associated 56 kDa Protein Kinase (1993) (4)
Erratum: Caveolin-1 is a novel regulator of K-RASdependent migration in colon carcinogenesis (International Journal of Cancer (2013) 133: 1 (43-57) DOI: 10.1002/ijc.28001) (2015) (3)
Sensitization of Chinese hamster ovary cells to heat shock by alpha-difluoromethylornithine. (1987) (3)
Enteraction of hyperthermia with radiations of different linerar energy transfer. (1977) (3)
Of Timing and Surrogates: A Way Forward for Cancer Chemoprevention (2011) (3)
Imaging of Colon Cancer in a Mouse Model (ApcMin) (2005) (2)
Serial endoscopy in azoxymethane treated mice using ultra-high-resolution optical coherence tomography (2007) (2)
Inhibition of Polyamine Synthesis Suppresses Growth and γ‐Ray‐Induced Sublethal and Potentially Lethal Damage Recovery in Human Tumor Cells in Culture (1993) (2)
HuRrying colon cancer progression (2008) (2)
Get the Fat Out! (2013) (2)
Hyperthermia in the treatment of human cancers (1986) (2)
Identifying gene copy number variants associated with colorectal adenoma recurrence (2010) (2)
NANT 2012-01: Phase 1 study of DFMO and celecoxib with cyclophosphamide and topotecan for relapsed or refractory high-risk neuroblastoma. (2018) (2)
A DNA polymerase alpha-associated 56 kDa protein kinase. (1993) (1)
Influence of Kras Activation on the Survival Responses of Caco-2 Cells to the Chemopreventive Agents Sulindac and Difluoromethylornithine 1 (2000) (1)
Changing winds in the war on cancer (2005) (1)
Post-translational modification of the protein-synthesis initiation factor eIF4D by spermidine in rat hepatoma cells (2005) (1)
538: The Effect of Difluoromethylornithine on Prostate Size and Polyamines in Men at Familial Risk for Prostate Cancer: Results of a One Year, Randomized, Double Blind, Placebo Controlled Chemoprevention Trial (2007) (1)
S6 Targeting polyamines and inflammation for cancer prevention (2010) (1)
Phosphorylation of nuclear and DNA-binding proteins in proliferating and quiescent mammalian cells. (1981) (1)
In vivo treatment of emt-6 mouse mammary sarcoma with localized hyperthermia plus interstitial radiation. Abstr. (1976) (1)
Abstract LB-179: Phase I trial of relapsed neuroblastoma with DFMO alone and in combination with etoposide. (2013) (1)
Hypusine biosynthesis in protein and its biological consequences. (1988) (1)
Therapeutic Strategies Targeting Polyamines (2004) (1)
Collateral sensitivity to methotrexate in adriamycin resistant cells (1977) (0)
Effects of non-steroidal anti-inflammatory drugs (NSAIDS) on ras mutation frequency, in colon cancers, and growth in cells expressing normal and mutant ras (1995) (0)
W1111 Effect of α-Difluoromethylornithine (DFMO) On Histopathology, Mucosal Polyamines, and Gene Expression Profiles in Patients with Dysplastic Barrett's Epithelium (2008) (0)
A phase IIa clinical biomarker trial of aspirin and dietary arginine restriction in colorectal cancer patients. (2011) (0)
804 Marked Efficacy of Difluoromethylornithine (DFMO) Plus Sulindac in Reducing Recurrent Colorectal Adenomas in Patients with Prior Adenomas: Results of a Randomized, Placebo-Controlled Double-Blind Trial (2008) (0)
Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas (2012) (0)
Polyamines in development, tissue repair and cancer. (2004) (0)
Increasing the ursodeoxycholate (UDC): deoxycholate (DCA) ratio in model fecal water solutions enhances apoptosis of colon cancer cells. Possible mechanism for cancer chemoprevention effect of UDC (2000) (0)
Reducing the risk of recurrent colon polyps. (2009) (0)
Session 4 S9. Genetically altered rodents and human tumor cells as preclinical models for prevention of intestinal cancers (2002) (0)
Effects ofCycloheximide onThermotolerance Expression, Heat ShockProtein Synthesis, andHeatShockProtein mRNA Accumulation inRatFibroblasts (1986) (0)
Mutations at hotspots in the P53 tumor suppressor gene in colonic carcinomas from azoxymethane (AOM) treated rats (1995) (0)
Polyamine modulation of c-myc expression and its effects on radioresponses of human glioblastoma cells (astro fellowship) (1991) (0)
123 Hypusine as a potential prognostic marker in glial derived brain tumors (1995) (0)
S27. Prevention of colorectal polyps by DMFO and Sulindac (2008) (0)
Perspectivesin CancerResearch Heat Shock Proteins in Thermotolerance and Other Cellular Processes 1 (2006) (0)
Abstract CN04-03: Development of NSAID eflornithine combinations for treating cancer risk factors (2012) (0)
Inducible gene expression strategies in gene therapy (2002) (0)
Abstract A61: Pilot study of difluoromethylornithine (DFMO) in patients with Barrett's esophagus and dysplasia (2008) (0)
Abstract LB-142: Marked efficacy of difluoromethylornithine plus sulindac in reducing recurrent colorectal adenomas in patients with prior adenomas: Results of a randomized, placebo-controlled, double-blind Phase III trial. (2008) (0)
Pharmacotherapy for patients with familial adenomatous polyposis (FAP). (2017) (0)
Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention. - eScholarship (2007) (0)
Role of obesity in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas. (2011) (0)
P30 23 WP – STRESS-INDUCED POLYAMINE ACETYLATION IN E. COLI (1991) (0)
Abstract 2765: Targeting both ornithine decarboxylase and polyamine transport inhibits tumor growth in neuroblastoma. (2013) (0)
Vitamin D and APC modulate molecular crosstalk between β-catenin/Wnt signaling and the vitamin D receptor in colon cancer cells (2007) (0)
Delayed Sensitizaron to Heat by Inhibitors of Polyamine-biosynthetic Enzymes 1 (2006) (0)
Elevation of intestinal polyamine content precedes tumor development in the min mouse (1998) (0)
Influenceof GrowthState on Several Thermal Responsesof EMT6IAz TumorCellsin Vitro1 (1979) (0)
ON THE TEMPORAL RELATIONSHIP BETWEEN NON-HISTONE PROTEIN SYNTHESIS AND DNA REPLICATION IN NORMAL AND IRRADIATED MAMMALIAN CELLS. (1974) (0)
Biological effects of hyperthermia and interaction with radiation (1990) (0)
Effect of (cid:97) -Difluoromethylornithine on Rectal Mucosal Levels of Polyamines in a Randomized, Double-Blinded Trial for Colon Cancer Prevention (1998) (0)
Effects of combination chemoprevention on markers of cell turnover and agent action in colorectal mucosal tissue from patients in a Phase III trial of difluoromethylornithine and sulindac for prevention of colon polyp recurrence (2007) (0)
P30 18 WP – DECREASED CELLULAR ADHESION AND LOSS OF CELL SURFACE INTEGRINS IN HUMAN TUMOR CELL LINES BY HEAT SHOCK (1991) (0)
Role of c-MYC in normal intestinal development and tumorigenesis in the ApcMin/+ mouse (2005) (0)
Diagnosis and treatment of carcinoma, based on the genotype of ODC1 (2010) (0)
Genetically altered rodents and human tumor cells as preclinical models for prevention of intestinal cancers (2002) (0)
Abstract A29: Rectal mucosal polyamine and PGE2 levels and risk of colorectal adenomas in a phase IIb/III trial of combination difluoromethylornithine (DFMO) plus sulindac (2010) (0)
Abstract PL01-04: ODC genotype as prognostic and predictive factors in colorectal carcinogenesis and prevention (2010) (0)
Dietary intakes and tissue concentrations of polyamines in a colon cancer chemoprevention clinical trial. (2006) (0)
Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer (2012) (0)
Enhancement of Hyperthermia @ inducedCytotoxicity by Polyamines 1 (2006) (0)
Abstract PR-01: Properties of adenomas in subjects treated with difluoromethylornithine and sulindac for reduction of colorectal adenomas (2011) (0)
P37 17 TP – POLYAMINE-DEPENDENT RADIATION RECOVERY PROCESSES IN RODENT AND HUMAN CELLS (1991) (0)
Effects of diethyldithiocarbamate and endogenous polyamine (2005) (0)
Gene-diet interactions in arginine-dependent intestinal carcinogenesis (2004) (0)

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