Eckard Wimmer | Academic Influence

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Eckard Wimmer

Biology

#849

World Rank

#1480

Historical Rank

#456

USA Rank

Virology

#60

World Rank

#63

Historical Rank

#24

USA Rank

biology Degrees

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Biology

Eckard Wimmer's Degrees

PhD Virology University of Vienna

Why Is Eckard Wimmer Influential?

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According to Wikipedia, Eckard Wimmer is a German American virologist, organic chemist and distinguished professor of molecular genetics and microbiology at Stony Brook University. He is best known for his seminal work on the molecular biology of poliovirus and the first chemical synthesis of a viral genome capable of infection and subsequent production of live viruses.

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Eckard Wimmer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation (1988) (1347)
Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily (1989) (1067)
Chemical Synthesis of Poliovirus cDNA: Generation of Infectious Virus in the Absence of Natural Template (2002) (908)
Primary structure, gene organization and polypeptide expression of poliovirus RNA (1981) (832)
Virus Attenuation by Genome-Scale Changes in Codon Pair Bias (2008) (588)
Genetics of poliovirus. (1993) (573)
Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. (1990) (423)
Protein-primed RNA synthesis by purified poliovirus RNA polymerase (1998) (408)
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo (1989) (401)
A protein covalently linked to poliovirus genome RNA. (1977) (395)
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein (1986) (389)
Cell-free, de novo synthesis of poliovirus. (1991) (384)
Intergeneric poliovirus recombinants for the treatment of malignant glioma. (2000) (355)
Systematic nomenclature of picornavirus proteins (1984) (351)
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220 (1987) (345)
Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses (2015) (343)
Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase. (1986) (336)
Reduction of the Rate of Poliovirus Protein Synthesis through Large-Scale Codon Deoptimization Causes Attenuation of Viral Virulence by Lowering Specific Infectivity (2006) (327)
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. (1993) (327)
Identification of an RNA Hairpin in Poliovirus RNA That Serves as the Primary Template in the In Vitro Uridylylation of VPg (2000) (311)
Molecular biology of picornaviruses (2002) (303)
Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. (1996) (299)
Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding. (1994) (254)
Nectin Couples Cell-Cell Adhesion and the Actin Scaffold at Heterotypic Testicular Junctions (2002) (252)
The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np. (1976) (240)
Similarity in gene organization and homology between proteins of animal picornaviruses and a plant comovirus suggest common ancestry of these virus families. (1984) (240)
The location of the polio genome protein in viral RNAs and its implication for RNA synthesis (1977) (239)
In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate (1984) (239)
Interaction of the poliovirus receptor with poliovirus. (2000) (236)
Viral proteinases. (1988) (232)
Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. (1982) (225)
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides (1983) (216)
Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site. (1990) (210)
Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication (1995) (204)
Polyadenylic acid at the 3'-terminus of poliovirus RNA. (1972) (198)
O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus. (1978) (193)
The 5'-terminal structures of poliovirion RNA and poliovirus mRNA differ only in the genome-linked protein VPg. (1977) (185)
Genetic analysis of the attenuation phenotype of poliovirus type 1 (1986) (181)
Genome-linked proteins of viruses (1982) (180)
Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus. (1996) (178)
Characterization of the Nucleoside Triphosphatase Activity of Poliovirus Protein 2C Reveals a Mechanism by Which Guanidine Inhibits Poliovirus Replication* (1999) (177)
Implications of the picornavirus capsid structure for polyprotein processing. (1987) (176)
Genetic and Biochemical Studies of Polioviruscis-Acting Replication Element cre in Relation to VPg Uridylylation (2000) (172)
Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus. (1991) (171)
Cis-acting RNA elements in human and animal plus-strand RNA viruses (2009) (168)
Guanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2C (1986) (166)
Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells (1986) (163)
Cellular receptors for animal viruses (1994) (163)
Live Attenuated Influenza Vaccines by Computer-Aided Rational Design (2010) (162)
Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides. (1989) (160)
Dual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence (1999) (160)
Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein (1991) (159)
Proteolytic processing of polyproteins in the replication of RNA viruses. (1989) (157)
Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus. (1983) (153)
Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I. (1988) (152)
Interaction of the Poliovirus Receptor CD155 with the Dynein Light Chain Tctex-1 and Its Implication for Poliovirus Pathogenesis* (2002) (147)
The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region (1994) (144)
Synthetic viruses: a new opportunity to understand and prevent viral disease (2009) (139)
Pyrite-induced hydroxyl radical formation and its effect on nucleic acids (2006) (139)
Complete Protein Linkage Map of Poliovirus P3 Proteins: Interaction of Polymerase 3Dpol with VPg and with Genetic Variants of 3AB (1998) (138)
MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network (138)
Properties of purified recombinant poliovirus protein 3aB as substrate for viral proteinases and as co-factor for RNA polymerase 3Dpol. (1994) (137)
Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies (1982) (136)
A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide (1982) (135)
Defective Interfering Particles of Poliovirus I. Isolation and Physical Properties (1971) (133)
Picornavirus Morphogenesis (2014) (132)
Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event. (2005) (131)
Protein processing map of poliovirus (1984) (129)
Loss of Nectin-2 at Sertoli-Spermatid Junctions Leads to Male Infertility and Correlates with Severe Spermatozoan Head and Midpiece Malformation, Impaired Binding to the Zona Pellucida, and Oocyte Penetration1 (2003) (129)
Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. (1983) (129)
Paradoxes of the replication of picornaviral genomes. (1999) (128)
Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus (1992) (127)
Direct Interaction between Two Viral Proteins, the Nonstructural Protein 2CATPase and the Capsid Protein VP3, Is Required for Enterovirus Morphogenesis (2010) (122)
Biochemical studies on poliovirus polypeptide 2C: evidence for ATPase activity. (1994) (117)
Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: genetic hybrids and the expression of a foreign gene. (1994) (116)
Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinases. (1987) (111)
Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals. (1984) (111)
Proteolytic Processing in the Replication of Polio and Related Viruses (1986) (111)
Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase (1992) (110)
Functional basis of poliovirus neutralization determined with monospecific neutralizing antibodies (1983) (109)
Antibody-complexed foot-and-mouth disease virus, but not poliovirus, can infect normally insusceptible cells via the Fc receptor. (1993) (108)
Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity (1986) (107)
Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection. (2002) (107)
Mechanism of Injury-Provoked Poliomyelitis (1998) (105)
Transformation of a human poliovirus receptor gene into mouse cells. (1986) (105)
New Ways of Initiating Translation in Eukaryotes? (2001) (104)
Stimulation of poliovirus proteinase 3Cpro-related proteolysis by the genome-linked protein VPg and its precursor 3AB. (1994) (103)
Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization (2014) (102)
cis-Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome (2004) (100)
Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Identification of a cis-Replicating Element in the Coding Sequence of 2Apro (2001) (99)
Processing of in vitro-synthesized gag precursor proteins of human immunodeficiency virus (HIV) type 1 by HIV proteinase generated in Escherichia coli (1988) (99)
Capsid protein VP4 of poliovirus is N-myristoylated. (1987) (97)
The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. (2001) (97)
Inhibition of basal transcription by poliovirus: a virus- encoded protease (3Cpro) inhibits formation of TBP-TATA box complex in vitro (1996) (97)
Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication (2007) (96)
Studies with poliovirus polymerase 3Dpol. Stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB. (1994) (96)
Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. (2006) (95)
Expression of a cloned gene segment of poliovirus in E. coli: Evidence for autocatalytic production of the viral proteinase (1984) (92)
Molecular dissection of the multifunctional poliovirus RNA-binding protein 3AB. (1995) (91)
Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice (2013) (91)
Brefeldin A Inhibits Cell-Free, De Novo Synthesis of Poliovirus (1998) (90)
Biochemical and Genetic Studies of the VPg Uridylylation Reaction Catalyzed by the RNA Polymerase of Poliovirus (2003) (90)
Interaction of Coxsackievirus A21 with Its Cellular Receptor, ICAM-1 (2001) (90)
Sequence Requirements for Viral RNA Replication and VPg Uridylylation Directed by the Internal cis-Acting Replication Element (cre) of Human Rhinovirus Type 14 (2002) (89)
A Cysteine-Rich Motif in Poliovirus Protein 2CATPaseIs Involved in RNA Replication and Binds Zinc In Vitro (2000) (88)
Polypeptide p41 of a Norwalk-Like Virus Is a Nucleic Acid-Independent Nucleoside Triphosphatase (2001) (88)
Functional Dissection of a Poliovirus cis-Acting Replication Element [PV-cre(2C)]: Analysis of Single- and Dual-cre Viral Genomes and Proteins That Bind Specifically to PV-cre RNA (2003) (87)
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro (1988) (87)
Studies of a putative amphipathic helix in the N-terminus of poliovirus protein 2C. (1994) (86)
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. (2005) (86)
A “Slide-back” Mechanism for the Initiation of Protein-primed RNA Synthesis by the RNA Polymerase of Poliovirus* (2003) (86)
Recruitment of Nectin-3 to Cell-Cell Junctions through trans-Heterophilic Interaction with CD155, a Vitronectin and Poliovirus Receptor That Localizes to αvβ3 Integrin-containing Membrane Microdomains* (2003) (86)
Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses (2008) (86)
Canyon rim residues, including antigenic determinants, modulate serotype-specific binding of polioviruses to mutants of the poliovirus receptor. (1995) (86)
The poliovirus receptor: identification of domains and amino acid residues critical for virus binding. (1994) (86)
The entire nucleotide sequence of the genome of human hepatitis A virus (isolate MBB). (1987) (85)
Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys. (1988) (85)
Identification of the initiation site of poliovirus polyprotein synthesis (1982) (85)
Vaccination against polio should not be stopped (2007) (85)
Genetic analysis of an NTP-binding motif in poliovirus polypeptide 2C. (1992) (84)
Replication of Poliovirus Requires Binding of the Poly(rC) Binding Protein to the Cloverleaf as Well as to the Adjacent C-Rich Spacer Sequence between the Cloverleaf and the Internal Ribosomal Entry Site (2007) (84)
Complexes of Poliovirus Serotypes with Their Common Cellular Receptor, CD155 (2003) (84)
Determinants of substrate recognition by poliovirus 2A proteinase (1992) (84)
Analysis of RNA synthesis of type 1 poliovirus by using an in vitro molecular genetic approach (1987) (83)
Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization (1983) (82)
Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase. (1991) (82)
Poliovirus can enter and infect mammalian cells by way of an intercellular adhesion molecule 1 pathway. (1991) (82)
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220 (1991) (81)
Cleavage of the cap binding protein complex polypeptide p220 is not effected by the second poliovirus protease 2A. (1986) (81)
Proteolytic processing of poliovirus polyprotein: elimination of 2Apro-mediated, alternative cleavage of polypeptide 3CD by in vitro mutagenesis. (1988) (80)
Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference (2015) (80)
Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity (1990) (78)
Genetics, Pathogenesis and Evolution of Picornaviruses (1999) (78)
Expression of Foreign Proteins by Poliovirus Polyprotein Fusion: Analysis of Genetic Stability Reveals Rapid Deletions and Formation of Cardioviruslike Open Reading Frames (1998) (78)
Studies on dicistronic polioviruses implicate viral proteinase 2Apro in RNA replication. (1993) (76)
Vectorial release of poliovirus from polarized human intestinal epithelial cells (1993) (75)
Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model. (2007) (74)
Replication of picornaviruses. I. Evidence from in vitro RNA synthesis that poly(A) of the poliovirus genome is genetically coded (1975) (74)
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication. (2007) (74)
A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus (1998) (73)
Defective interfering particles of poliovirus: mapping of the deletion and evidence that the deletions in the genomes of DI(1), (2) and (3) are located in the same region. (1979) (73)
Cell recognition and entry by rhino- and enteroviruses. (2000) (72)
Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication. (1993) (72)
Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors (1993) (71)
RNA Signals in Entero- and Rhinovirus Genome Replication☆ (1997) (71)
Initiation of protein-primed picornavirus RNA synthesis. (2015) (70)
Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1. (1991) (70)
Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus (1990) (70)
Cleavage sites within the poliovirus capsid protein precursors (1982) (67)
Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing. (1981) (67)
Translation of encephalomyocarditis virus RNA by internal ribosomal entry. (1995) (67)
Maturation of poliovirus capsid proteins. (1992) (67)
Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy (2021) (67)
Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2 (1991) (66)
HIV- 1 Protease Inhibits Cap- and Poly(A)-Dependent Translation upon eIF4GI and PABP Cleavage (2009) (65)
Effects of temperature and lipophilic agents on poliovirus formation and RNA synthesis in a cell-free system (1993) (65)
Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg (1990) (65)
Poly (A) and poly (U) in poliovirus double stranded RNA. (1973) (65)
Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog* (2002) (63)
Molecular characterization of the cellular receptor for poliovirus. (1994) (62)
Factors affecting the detection of enteroviruses in cerebrospinal fluid with coxsackievirus B3 and poliovirus 1 cDNA probes (1985) (61)
Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro). (2001) (61)
The test‐tube synthesis of a chemical called poliovirus (2006) (60)
In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain (1985) (60)
The genome-linked protein of picornaviruses. IV. Difference in the VPg's of encephalomyocarditis virus and poliovirus as evidence that the genome-linked proteins are virus-coded. (1978) (59)
"Fingerprinting" high molecular weight RNA by two-dimensional gel electrophoresis: application to poliovirus RNA. (1976) (59)
Interaction of polypyrimidine tract binding protein with the encephalomyocarditis virus mRNA internal ribosomal entry site. (1993) (59)
Mutation of a Single Conserved Nucleotide between the Cloverleaf and Internal Ribosome Entry Site Attenuates Poliovirus Neurovirulence (2005) (59)
Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets. (2016) (58)
Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase (1990) (58)
The genome-linked protein of picornaviruses. VII. Genetic mapping of poliovirus VPg by protein and RNA sequence studies (1980) (56)
Genetic Analysis of a Poliovirus/Hepatitis C Virus Chimera: New Structure for Domain II of the Internal Ribosomal Entry Site of Hepatitis C Virus (2001) (55)
Mutational analysis of the genome-linked protein VPg of poliovirus (1988) (55)
Statement on Scientific Publication and Security (2003) (55)
Sequence studies of satellite tobacco necrosis virus RNA. Isolation and characterization of a 5'-terminal trinucleotide. (1968) (54)
Polyprotein processing in picornavirus replication. (1988) (54)
Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis (1994) (53)
Sequence studies of poliovirus RNA. IV. Nucleotide sequence complexities of poliovirus type 1, type 2 and two type 1 defective interfering particles RNAs, and fingerprint of the poliovirus type 3 genome. (1979) (52)
Sequence studies of poliovirus RNA. III. Polyuridylic acid and polyadenylic acid as components of the purified poliovirus replicative intermediate. (1975) (52)
Guanidine-dependent mutants of poliovirus: identification of three classes with different growth requirements. (1987) (51)
Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate (2015) (50)
Putting Synthesis into Biology: A Viral View of Genetic Engineering through De Novo Gene and Genome Synthesis (2009) (50)
Regulation of Gene Expression in Animal Viruses (1993) (50)
Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg. (2000) (49)
Genetic recombination of poliovirus in a cell-free system. (1997) (49)
Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter (1992) (49)
The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage. (2001) (49)
Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNA (1981) (49)
The Genome-Linked Protein of Picornaviruses (1980) (48)
Molecular Biology of Picornavirus (2002) (48)
Molecular Events Leading to Picornavirus Genome Replication (1987) (48)
Poliovirus/Hepatitis C Virus (Internal Ribosomal Entry Site-Core) Chimeric Viruses: Improved Growth Properties through Modification of a Proteolytic Cleavage Site and Requirement for Core RNA Sequences but Not for Core-Related Polypeptides (1999) (47)
A conserved AUG triplet in the 5' nontranslated region of poliovirus can function as an initiation codon in vitro and in vivo. (1994) (46)
Recombinants of Mahoney and Sabin strain poliovirus type 1: analysis of in vitro phenotypic markers and evidence that resistance to guanidine maps in the nonstructural proteins. (1984) (46)
Sequence studies of poliovirus RNA. I. Characterization of the 5'-terminus. (1972) (46)
Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions (1994) (45)
Cleavage sites in the polypeptide precursors of poliovirus protein P2-X. (1981) (45)
Identification of cellular proteins enhancing activities of internal ribosomal entry sites by competition with oligodeoxynucleotides. (2004) (43)
Analysis of picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions (1995) (43)
The genome of poliovirus is an exceptional eukaryotic mRNA. (1976) (43)
Viral Proteinases As Targets for Chemotherapy (1989) (43)
Cis-acting elements of the encephalomyocarditis virus internal ribosomal entry site. (1995) (42)
Alanine Scanning of Poliovirus 2CATPase Reveals New Genetic Evidence that Capsid Protein/2CATPase Interactions Are Essential for Morphogenesis (2012) (42)
Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II (1989) (42)
Carboxy-terminal analysis of poliovirus proteins: termination of poliovirus RNA translation and location of unique poliovirus polyprotein cleavage sites (1982) (42)
Statement on the consideration of biodefence and biosecurity (2003) (41)
Expression in Escherichia coli and purification of human immunodeficiency virus type 1 capsid protein (p24). (1990) (41)
Identification of a poliovirus neutralization epitope through use of neutralizing antiserum raised against a purified viral structural protein. (1983) (41)
Identification of a Nuclear Respiratory Factor-1 Binding Site within the Core Promoter of the human polio virus receptor/CD155 Gene* (2000) (40)
Identification of a new neutralization antigenic site on poliovirus coat protein VP2 (1984) (40)
Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120 (1995) (40)
Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus. (2007) (40)
Dengue and Zika Virus 5′ Untranslated Regions Harbor Internal Ribosomal Entry Site Functions (2019) (39)
Mutational analysis of the proposed FG loop of poliovirus proteinase 3C identifies amino acids that are necessary for 3CD cleavage and might be determinants of a function distinct from proteolytic activity (1992) (39)
Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design (2012) (38)
Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro (1980) (37)
Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure (2017) (37)
Antigenic conservation and divergence between the viral-specific proteins of poliovirus type 1 and various picornaviruses. (1985) (37)
Molecular cloning of the genome of poliovirus type 1. (1981) (37)
Poliovirus RNA synthesis in vitro: structural elements and antibody inhibition. (1983) (37)
Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity. (1996) (36)
The Promoters for Human and Monkey Poliovirus Receptors (1997) (36)
Binding of Glutathione to Enterovirus Capsids Is Essential for Virion Morphogenesis (2014) (36)
An Interaction between Glutathione and the Capsid Is Required for the Morphogenesis of C-Cluster Enteroviruses (2014) (36)
Poliovirus single-stranded RNA and double-stranded RNA: differential infectivity in enucleate cells (1978) (35)
Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants. (1988) (35)
Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Purification and Enzymatic Analysis of the RNA-Dependent RNA Polymerase 3Dpol (2001) (35)
Genetic recombination of poliovirus in vitro and in vivo: temperature-dependent alteration of crossover sites. (1999) (34)
Picornaviral VPg sequences are contained in the replicase precursor (1980) (34)
Poly(U) in poliovirus minus RNA is 5'-terminal. (1974) (34)
The structure of poliovirus replicative form. (1980) (34)
A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells (1992) (33)
STRUCTURE AND EXPRESSION OF THE PICORNAVIRUS GENOME * (1980) (33)
Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA. (2000) (33)
Analysis of the cloverleaf element in a human rhinovirus type 14/poliovirus chimera: correlation of subdomain D structure, ternary protein complex formation and virus replication. (2003) (32)
Genetic variation of the poliovirus genome with two VPg coding units. (1996) (32)
Synthetic poliovirus and other designer viruses: what have we learned from them? (2011) (31)
Replication of poliovirus RNA containing two VPg coding sequences leads to a specific deletion event (1993) (31)
Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. (1990) (31)
Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro (1994) (30)
The antiviral compound 5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic cleavages and the assembly of poliovirus in a cell-free system. (2000) (30)
Mononucleotide and dinucleotide frequencies, and codon usage in poliovirion RNA. (1981) (29)
Bidirectional entry of poliovirus into polarized epithelial cells (1993) (29)
Tyrosine 3 of Poliovirus Terminal Peptide VPg(3B) Has an Essential Function in RNA Replication in the Context of Its Precursor Protein, 3AB (2007) (29)
Uncensored exchange of scientific results (2003) (29)
An electron microscope study of the proteins attached to polio virus RNA and its replicative form (RF). (1978) (28)
Will the polio niche remain vacant? (2001) (28)
Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis (1995) (27)
The Genome-Linked Protein of Picornaviruses: Discovery, Properties and Possible Functions (1979) (27)
Identification of point mutations in the genome of the poliovirus Sabin vaccine LSc 2ab, and catalogue of RNase T1- and RNase A-resistant oligonucleotides of poliovirus type 1 (Mahoney) RNA. (1981) (27)
Intragenomic complementation of a 3AB mutant in dicistronic polioviruses. (1995) (26)
Poliovirus protease 3C (P3-7c) does not cleave P220 of the eucaryotic mRNA cap-binding protein complex (1985) (26)
Identification of specific fragments containing the 5' end of poliovirus RNA after ribonuclease III digestion. (1978) (26)
The fate of VPg during in vitro translation of poliovirus RNA (1981) (25)
Improved distribution of antigenic site specificity of poliovirus-neutralizing antibodies induced by a protease-cleaved immunogen in mice (1990) (25)
IRES-controlled protein synthesis and genome replication of poliovirus. (1994) (25)
Interaction of poliovirus with its cell surface binding site. (1994) (25)
Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Identification of a cis-Replicating Element in the Coding Sequence of 2A (2001) (25)
Vaccinia virus-mediated expression and identification of the human poliovirus receptor. (1991) (25)
A poliovirus mutant defective for self-cleavage at the COOH-terminus of the 3C protease exhibits secondary processing defects. (1988) (24)
Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro (2005) (24)
Genetic Analysis of a Poliovirus/Hepatitis C Virus (HCV) Chimera: Interaction between the Poliovirus Cloverleaf and a Sequence in the HCV 5′ Nontranslated Region Results in a Replication Phenotype (2000) (24)
Identification and Characterization of the cis-Acting Elements of the Human CD155 Gene Core Promoter* (1999) (24)
Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo. (2010) (24)
Natural variants of the Sabin type 1 vaccine strain of poliovirus and correlation with a poliovirus neutralization site. (1985) (24)
Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as determined by a modification of the dideoxynucleotide method. (1980) (24)
Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes. (1992) (24)
The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. (2003) (24)
Growth phenotypes and biosafety profiles in poliovirus‐receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses (2008) (23)
Protein synthesis during aging of human cells in culture. Direction by polio virus. (1975) (23)
Internal ribosomal entry site scanning of the poliovirus polyprotein: implications for proteolytic processing. (1998) (23)
Stimulation of Poliovirus Synthesis in a HeLa Cell-Free In Vitro Translation-RNA Replication System by Viral Protein 3CDpro (2005) (22)
Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine (2016) (22)
A Single Amino Acid Substitution in Poliovirus Nonstructural Protein 2CATPase Causes Conditional Defects in Encapsidation and Uncoating (2016) (22)
A C-terminal, cysteine-rich site in poliovirus 2C(ATPase) is required for morphogenesis. (2014) (21)
The Making of a Picornavirus Genome (2010) (21)
The role of proteolytic processing in the morphogenesis of virus particles (1992) (21)
Two 3′-Terminal Sequences in Satellite Tobacco Necrosis Virus RNA (1969) (21)
Cellular Receptors of Picornaviruses: an Overview (2002) (21)
Reply to Simmonds et al.: Codon pair and dinucleotide bias have not been functionally distinguished (2015) (20)
A Host-Specific, Temperature-Sensitive Translation Defect Determines the Attenuation Phenotype of a Human Rhinovirus/Poliovirus Chimera, PV1(RIPO) (2011) (20)
Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector (2011) (20)
The genome-linked protein of picornaviruses. VIII. Complete amino acid sequence of poliovirus VPg and carboxy-terminal analysis of its precursor, P3-9. (1983) (20)
Enterovirus Structure and Assembly (1995) (20)
Construction and characterization of a poliovirus/rhinovirus antigenic hybrid. (1991) (19)
Molecular biology and cell-free synthesis of poliovirus. (1993) (19)
Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids. (1987) (18)
Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes (2017) (18)
Poliovirus antigenic sites and vaccines (1984) (17)
Dicistronic polioviruses as expression vectors for foreign genes. (1994) (16)
Pyrophosphate in the 5' Terminal Position of a Viral Ribonucleic Acid (1968) (16)
N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor (1992) (15)
The human poliovirus receptor alpha is a serine phosphoprotein (1994) (15)
The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection. (1992) (15)
Genetic Analysis oftheAttenuation Phenotype ofPoliovirus Type1 (1986) (15)
Mapping Neutralization Domains of Viruses (1986) (15)
Uridylylation of the genome-linked protein of poliovirus in vitro is dependent upon an endogenous RNA template. (1987) (15)
Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction (1998) (14)
Restricted fragmentation of poliovirus type 1, 2 and 3 RNAs by ribonuclease III. (1979) (14)
Production of high titer attenuated poliovirus strains on the serum-free PER.C6(®) cell culture platform for the generation of safe and affordable next generation IPV. (2015) (14)
Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells. (2005) (14)
7 Poliovirus Receptors (1994) (14)
Don't drop current vaccine until we have new ones (2005) (14)
Evolution of Poliovirus Defective Interfering Particles Expressing Gaussia Luciferase (2011) (13)
Viral proteases as targets for chemotherapeutic intervention (1992) (13)
Specificity of the polioviral proteinase 3C towards genetically engineered cleavage sites in the viral capsid. (1991) (13)
The relation of prophylactic inoculations to the onset of poliomyelitis (1999) (12)
Determinants of poliovirus neurovirulence. (1997) (12)
The C-Terminal Hydrophobic Domain of Hepatitis C Virus RNA Polymerase NS5B Can Be Replaced with a Heterologous Domain of Poliovirus Protein 3A (2006) (12)
Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO) (2013) (12)
Rhodomycine, VIII; Antibiotica aus Actinomyceten, LI: Die Konstitution des β‐, γ‐, ϵ‐ und ζ‐Rhodomycinons (1965) (12)
Aspects of the Molecular Biology of Poliovirus Replication (1993) (11)
Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication : Purification and Enzymatic Analysis of the RNA-Dependent RNA Polymerase 3 Dpol (2001) (11)
Phenotypic characterization of antigenic hybrids of poliovirus. (1991) (11)
Polio eradication at the crossroads. (2021) (11)
Molecular events leading to poliovirus genome replication. (1987) (10)
Optimization of the Codon Pair Usage of Human Respiratory Syncytial Virus Paradoxically Resulted in Reduced Viral Replication In Vivo and Reduced Immunogenicity (2019) (10)
The genomic map of hepatitis A virus: an alternate analysis. (1986) (10)
Extensive genomic recoding by codon-pair deoptimization selective for mammals is a flexible tool to generate attenuated vaccine candidates for dengue virus 2. (2019) (10)
In vitro synthesis of poliovirus. (1993) (10)
Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes (2018) (10)
Poliomyelitis in transgenic mice expressing CD155 under the control of the Tage4 promoter after oral and parenteral poliovirus inoculation. (2014) (10)
Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Puriﬁcation and Enzymatic Analysis of the RNA-Dependent RNA Polymerase 3D pol (2001) (10)
The Human Poliovirus Receptor (1995) (9)
Comparison of African, Asian, and American Zika Viruses in Swiss Webster mice: Virulence, neutralizing antibodies, and serotypes (2016) (9)
The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication (2002) (9)
Model of Picornavirus RNA Replication (2009) (8)
The effect of site and mode of expression of a heterologous antigenic determinant on the properties of poliovirus hybrids. (1991) (8)
Cleavage site of the poliovirus receptor signal sequence. (1994) (8)
Mutational Analysis oftheProposed FG LoopofPoliovirus Proteinase 3CIdentifies AminoAcidsThatAreNecessary for 3CDCleavage andMightBeDeterminants ofaFunction Distinct fromProteolytic Activity (1992) (7)
Brunenders: a partially attenuated historic poliovirus type I vaccine strain. (2015) (7)
Antibodies may act synergistically or additively with interferon to inhibit poliovirus. (1991) (7)
20 – Proteolytic Processing of the Poliovirus Polyprotein by Two Virus-Encoded Proteinases (1973) (7)
Synthese von Descarbomethoxy‐η‐iso‐pyrromycinon und anderen Hydroxy‐tetracenchinonen (1963) (6)
Novel approaches to picornavirus vaccines. (1990) (6)
Vaccines should be kept even if polio is wiped out (2002) (6)
The Role of RNA-Binding Proteins in IRES-Dependent Translation (2002) (6)
Chemical Synthesis of Poliovirus Peptides and Neutralizing Antibody Responses (1988) (5)
Eradicating polio: A balancing act. (2016) (5)
Synthesis of infectious poliovirus RNA by purified T 7 RNA polymerase ( poliovirus cDNA / T 7 promoter ) (2003) (5)
POLIOVIRUSES (PICORNAVIRIDAE) | Molecular Biology (1999) (4)
Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides. (2009) (4)
Characterization of the New World Monkey Homologues of Human Poliovirus Receptor CD155 (2008) (4)
The immune response to poliovirus-specific synthetic peptides: effects of adjuvants and test animal species. (1985) (4)
Expression in E. coli and Purification of Human Immunodeficiency Virus Type 1 Major Core Protein, p24 (1990) (3)
Mutational analysis of a native substrate of the HIV-1 proteinase. (1991) (3)
Synthetic Biology, Dual Use Research, and Possibilities for Control (2018) (3)
Synthetic Biology Approaches for Vaccine Development (2014) (3)
Characterization ofPoliovirus 2AProteinase byMutational Analysis: Residues Required forAutocatalytic Activity AreEssential forInduction ofCleavage ofEukaryotic Initiation Factor 4FPolypeptide p220 (1991) (3)
11 – The Polio virus Genome: A Unique RNA in Structure, Gene Organization, and Replication (1987) (3)
Rescue of codon-pair deoptimized respiratory syncytial virus by the emergence of genomes with very large internal deletions that complemented replication (2021) (3)
Neutralization antigenic sites of poliovirus and peptide induction of neutralizing antibodies. (1984) (2)
Two different murine sarcoma virus isolates have homologous genome sequences: implication for their origin. (1978) (2)
VPg: THE GENOME LINKED PROTEIN OF PICORNAVIRUSES (1980) (2)
Poliovirus replication proteins : RNA sequence encoding P 3lb and the sites of proteolytic processing ( protein sequence analysis / picornavirus / genome map / proteinase ) (2)
Structure, Possible Function, and Biosynthesis of VPg, the Genome-linked Protein of Poliovirus (1981) (2)
Capsid protein VP 4 of poliovirus is N-myristoylated ( protein modification / fatty acylation of proteins / picornaviruses ) (2)
Mutational Analysis oftheGenome-Linked Protein VPgofPoliovirus (1988) (2)
04-( 5 '-Uridylyl ) tyrosine is the bond between the genome-linked protein and the RNA of poliovirus * ( iodination / acid and alkali hydrolysis / enzymatic degradation / paper electrophoresis and chromatography ) (2004) (2)
Replication of the Poliovirus Genome (2018) (1)
Erratum: Uncensored exchange of scientific results (Proceedings of the National Academy of Sciences (2003) 100, 4, (1464) DOI: 10.1073/pnas.0630491100) (2012) (1)
Peptide priming of a poliovirus neutralizing antibody response. (1984) (1)
RNA replication . and 3 AB / 3 CDpro of poliovirus is essential for Interaction between the 5 '-terminal cloverleaf (1995) (1)
Organization of the poliovirus genome and the sites for proteolytic processing (1984) (1)
The crystal structure of coxsackievirus A21 (2005) (1)
SEQUENCE ANALYSIS OF THE POLIOVIRUS GENOME AND MAPPING OF THE GENOME-LINKED PROTEIN (1980) (1)
Viral genetics. (1992) (1)
Isolation of escape mutants of a hybrid poliovirus with the aid of insert-specific polyclonal antibodies. (1995) (1)
The genome-linked protein of picornaviruses. VI. The 5'-terminal protein of poliovirus type 2RNA is covalently linked to a nonanucleotide identical to that of poliovirus type 1 RNA. (1980) (1)
Eatenued vira use for vaccines (2008) (0)
CryoEM structure of poliovirus receptor bound to poliovirus type 1 (2008) (0)
[Rhodomycin, 8. Antibiotics from Actinomycetes, LI. Structure of beta-, gamma-, epsilon- and zeta-rhodomycinone]. (1965) (0)
proSequence of 2 A-Replicating Element in the Coding cis Replication : Identification of a Initiation of Human Rhinovirus 2 RNA Biochemical and Genetic Studies of the (2001) (0)
Nucleic Acids Research (0)
CryoEM structure of poliovirus receptor bound to poliovirus type 2 (2008) (0)
Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 (2000) (0)
Restriction map of poliovirus type 2 cDNA. (1981) (0)
The molecular biology of poliovirus By F. Koch and G. Koch. New York: Springer-Verlag. (1985). 590 pp. $74.00 (1986) (0)
Introducing recombinant picornaviral genomes into cells. (2011) (0)
InVitro Phenotypic Markers ofaPoliovirus Recombinant Constructed fromInfectious cDNAClones oftheNeurovirulent MahoneyStrain andtheAttenuated Sabin 1Strain (1985) (0)
Preface/Front Matter (1994) (0)
Synchrotron radiation-induced X-ray emission to identify metal ions in preparations of purified protein. (2002) (0)
Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi (2005) (0)
Initiation ofPoliovirus Plus-Strand RNA Synthesis ina Membrane ComplexofInfected HeLaCells (1986) (0)
Establishment of a CPER Reverse Genetics System for Powassan Virus Defines Attenuating NS1 Glycosylation Sites and an Infectious NS1-GFP11 Reporter Virus (2023) (0)
Profile of Eckard Wimmer. Interview by Sujata Gupta. (2013) (0)
Eleventh International Chromosome Conference (2004) (0)
Encephalomyocarditis VirusInternal Ribosomal EntrySite RNA-Protein Interactions (1994) (0)
Dengue and Zika virus 5’-UTRs harbor IRES functions (2019) (0)
Foreword (2020) (0)
Poliovirus morphogenesis in a cell-free system (1996) (0)
Myristoylation ofthePoliovirus Polyprotein IsRequired for Proteolytic Processing oftheCapsid andforViral Infectivity (1990) (0)
An impact of synthetic virology: Recoding arboviruses for vaccine development (2017) (0)
Synthese des Descarbomethoxy-η-iso-pyrromycinons (2004) (0)
gag Precursor Proteins of HumanImmunodeficiency Virus(HIV)Type1 byHIV Proteinase Generated inEscherichia coli (1988) (0)
17 Expression of Viral Receptors and the Vectorial Release of Viruses in Polarized Epithelial Cells (1994) (0)
Pseudo-atomic Structure of Coxsackievirus A21 Complexed with Its Cellular Receptor, ICAM-1 (2002) (0)
Oncolytic Poliovirus Therapy in a Mouse Model of Neuroblastoma: Preclinical Data Analysis and Future Studies (2012) (0)
Fingerprint analyses of cytoplasmic adenovirus 2 RNA size classes synthesized late in productive infection. (1975) (0)
AN IMPACT OF DE NOVO SYNTHESIZING POLIOVIRUS: RECODING ARBOVIRUSES FOR VACCINE DEVELOPMENT (2019) (0)
Structure, Proteolytic Processing, and Neutralization Antigenic Sites of Poliovirus (1984) (0)
Nucleic Acids Research Production of infectious poUovirus from doited cDNA b dramatically increased by SV40 transcription and replication signals (2005) (0)
Sequence between the Cloverleaf and the Internal Ribosomal Entry Site. 3 (2007) (0)
S1933 The Difference of Hepatitis C Viral (HCV) Internal Ribosomal Entry Site (Ires) and Picornaviral Ires-Mediated Translation Inhibited By Oligonucleotides (2008) (0)
Poliovirus receptor CD155 D1D2 (2008) (0)
involvement of a cellular 57-kD RNA-binding protein. structural elements of the internal ribosomal entry site and Cap-independent translation of encephalomyocarditis virus RNA: (2007) (0)
CryoEM structure of poliovirus receptor bound to poliovirus (2004) (0)
Poliovirus antigenic sites and vaccines/A vailability of Mo and HTLV-II/Limitations of physical theory/Interstitial fluid (1984) (0)
CryoEM structure of poliovirus receptor bound to poliovirus type 3 (2008) (0)
Table of Contents (1996) (0)
Proteolytic processing of poliovirus polypeptides: Antibodies (2003) (0)

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