Eckhard R. Podack

Eckhard R. Podack's AcademicInfluence.com Rankings

Eckhard R. Podack

Biology

#7517

World Rank

#10454

Historical Rank

Immunology

#410

World Rank

#425

Historical Rank

biology Degrees

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Biology

Eckhard R. Podack's Degrees

Masters Medicine University of Miami
PhD Immunology University of Miami

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Eckhard R. Podack's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice (1994) (1948)
Immunological mechanisms of the antitumor effects of supplemental oxygenation (2015) (414)
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules. (1985) (396)
Structure and function of human perforin (1988) (323)
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. (2002) (313)
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice (1996) (307)
Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity (1986) (306)
A central role of perforin in cytolysis? (1991) (297)
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization (1984) (291)
The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities. (1986) (261)
Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells (1983) (240)
Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway (1995) (229)
Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes (1983) (226)
Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells. (1996) (202)
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain (1997) (202)
The molecular mechanism of lymphocyte-mediated tumor cell lysis. (1985) (190)
Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2. (1993) (189)
Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. (1993) (181)
Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation (2008) (172)
Isolation of human S-protein, an inhibitor of the membrane attack complex of complement. (1979) (172)
Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9 (1982) (153)
Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins (1979) (150)
Membrane attack by complement. (1984) (150)
Polymerization of the ninth component of complement (C9): formation of poly(C9) with a tubular ultrastructure resembling the membrane attack complex of complement. (1982) (149)
Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines. (1998) (148)
Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function. (1997) (146)
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection (2014) (146)
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. (2010) (145)
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. (1997) (144)
Structure and expression of murine CD30 and its role in cytokine production. (1996) (140)
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. (1997) (140)
Cutting edge: tumor secreted heat shock-fusion protein elicits CD8 cells for rejection. (1999) (138)
The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum. (1978) (133)
The SC5b-7 complex: formation, isolation, properties, and subunit composition. (1977) (131)
C1q: isolation from human serum in high yield by affinity chromatography and development of a highly sensitive hemolytic assay. (1979) (130)
CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway. (1999) (123)
The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model (2011) (117)
Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease. (2015) (113)
Characterization of three serine esterases isolated from human IL-2 activated killer cells. (1988) (112)
T-cell effector functions: mechanisms for delivery of cytotoxicity and help. (1991) (112)
Inhibition of C9 polymerization within the SC5b-9 complex of complement by S-protein. (1984) (109)
Perforin is required for innate and adaptive immunity induced by heat shock protein gp96. (2003) (107)
Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer. (2004) (106)
Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9. (1989) (105)
Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis (1989) (105)
Ultrastructure of the membrane attack complex of complement: detection of the tetramolecular C9-polymerizing complex C5b-8. (1982) (105)
Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis. (1998) (102)
Defining the roles of perforin, Fas/FasL, and tumour necrosis factor α in T cell induced mucosal damage in the mouse intestine (2002) (100)
IL-2 Receptor Signaling Is Essential for the Development of Klrg1+ Terminally Differentiated T Regulatory Cells (2012) (100)
Decrease in CD3-negative-CD8dim(+) and Vdelta2/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection. (2002) (99)
Membrane attack complex of complement: generation of high-affinity phospholipid binding sites by fusion of five hydrophilic plasma proteins. (1979) (98)
CD30 Signals Integrate Expression of Cytotoxic Effector Molecules, Lymphocyte Trafficking Signals, and Signals for Proliferation and Apoptosis1 (2000) (98)
The membrane attack mechanism of complement: photolabeling reveals insertion of terminal proteins into target membrane. (1981) (95)
Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules (1986) (91)
CD30/CD30 Ligand (CD153) Interaction Regulates CD4+ T Cell-Mediated Graft-versus-Host Disease1 (2004) (88)
Binding of desoxycholate, phosphatidylcholine vesicles, lipoprotein and of the S-protein to complexes of terminal complement components. (1978) (87)
C5b-9 dimer: isolation from complement lysed cells and ultrastructural identification with complement-dependent membrane lesions (1979) (86)
Age-Related Decline of Perforin Expression in Human Cytotoxic T Lymphocytes and Natural Killer Cells (1998) (80)
Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes (1986) (79)
Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways. (1995) (78)
Functional channel formation associated with cytotoxic T-cell granules. (1986) (78)
Structure of the human perforin gene. A simple gene organization with interesting potential regulatory sequences. (1989) (78)
Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-κB (1997) (78)
Interleukin-6 cDNA transfected Lewis lung carcinoma cells show unaltered net tumour growth rate but cause weight loss and shortened survival in syngeneic mice. (1993) (77)
CD30: an important new target in hematologic malignancies (2011) (76)
Molecular reorganization of lipid bilayers by complement: a possible mechanism for membranolysis. (1979) (75)
The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7. (1985) (75)
TCR-Independent CD30 Signaling Selectively Induces IL-13 Production Via a TNF Receptor-Associated Factor/p38 Mitogen-Activated Protein Kinase-Dependent Mechanism1 (2002) (75)
Characteristics of Perforin Expressing Lymphocytes Within the First Trimester Decidua of Human Pregnancy (1995) (73)
B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion (2012) (73)
Perforin expression by thyroid‐infiltrating T cells in autoimmune thyroid disease (1994) (71)
Induction of a TRAIL mediated suicide program by interferon alpha in primary effusion lymphoma (2001) (70)
Circular polymerization of the ninth component of complement. Ring closure of the tubular complex confers resistance to detergent dissociation and to proteolytic degradation. (1982) (68)
Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation. (1993) (68)
Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria (2015) (67)
Inhibition of Intracellular Bacterial Replication in Fibroblasts Is Dependent on the Perforin-Like Protein (Perforin-2) Encoded by Macrophage-Expressed Gene 1 (2012) (67)
Membrane attack complex of complement: a structural analysis of its assembly (1980) (66)
The membrane attack complex of complement: C5b-8 complex as accelerator of C9 polymerization. (1985) (65)
Lung cancer immunotherapy. (2005) (65)
Perforin expression in human peripheral blood mononuclear cells. Definition of an IL-2-independent pathway of perforin induction in CD8+ T cells. (1992) (63)
Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. (2001) (61)
Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. (1992) (61)
Abundant perforin expression at the maternal-fetal interface: guarding the semiallogeneic transplant? (2000) (60)
Activation of complement by serum-resistant Neisseria gonorrhoeae. Assembly of the membrane attack complex without subsequent cell death (1982) (60)
Functional significance of two cytolytic pathways of cytotoxic T lymphocytes (1995) (60)
Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice. (1995) (60)
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. (2008) (59)
CD30 Ligand/CD30 Plays a Critical Role in Th17 Differentiation in Mice (2010) (58)
Progesterone Induced Blocking Factor (PIBF) Mediates Progesterone Induced Suppression of Decidual Lymphocyte Cytotoxicity (2002) (58)
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors. (1996) (58)
CD30-regulated apoptosis in murine CD8 T cells after cessation of TCR signals. (1997) (57)
The role of C9 in complement-mediated killing of Neisseria. (1981) (57)
Purification of the sixth and seventh component of human complement without loss of hemolytic activity. (1976) (57)
A Novel Role of CD30L/CD30 Signaling by T-T Cell Interaction in Th1 Response against Mycobacterial Infection1 (2008) (56)
Immunotherapy as a strategy for the treatment of non-small-cell lung cancer. (2011) (55)
Azidothymidine and Interferon-α Induce Apoptosis in Herpesvirus-associated Lymphomas (1999) (54)
Molecular weight of poly(C9). 12 to 18 C9 molecules form the transmembrane channel of complement. (1984) (53)
Killing machines: three pore-forming proteins of the immune system (2013) (53)
B cell regulation of anti-tumor immune response (2013) (53)
Pleiotropic effects of Bcl-2 on transcription factors in T cells: potential role of NF-kappa B p50-p50 for the anti-apoptotic function of Bcl-2. (1995) (52)
Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines. (1994) (52)
A Novel Role of CD30/CD30 Ligand Signaling in the Generation of Long-Lived Memory CD8+ T Cells1 (2005) (52)
Tumor-induced suppression of CTL expansion and subjugation by gp96-Ig vaccination. (2009) (49)
The C5b-6 complex: reaction with C7, C8, C9. (1978) (49)
SC5b-9 complex of complement: formation of the dimeric membrane attack complex by removal of S-protein. (1980) (49)
Structural similarities between C6 and C7 of human complement. (1979) (49)
Surmounting Tumor-induced Immune Suppression by Frequent Vaccination or Immunization in the Absence of B Cells (2008) (47)
Heat shock protein-based cancer vaccines. (2006) (47)
Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages (2013) (47)
Analysis of perforin expression in human peripheral blood lymphocytes, CD56+ natural killer cell subsets and its induction by interleukin-2. (1995) (46)
Combination effect of vaccination with IL2 and IL4 cdna transfected cells on the induction of a therapeutic immune response against lewis lung carcinoma cells (1993) (46)
The interaction of C5 with C3b in free solution: a sufficient condition for cleavage by a fluid phase C3/C5 convertase. (1980) (46)
CD30: from basic research to cancer therapy (2013) (46)
Cloning, Expression, and Functional Characterization of TL1A-Ig (2013) (46)
Cutting Edge: Novel Vaccination Modality Provides Significant Protection against Mucosal Infection by Highly Pathogenic Simian Immunodeficiency Virus (2013) (45)
CD30—Governor of Memory T Cells? (2002) (45)
Tumor immunogenicity and responsiveness to cancer vaccine therapy: the state of the art. (2010) (44)
Tregs Expanded In Vivo by TNFRSF25 Agonists Promote Cardiac Allograft Survival (2012) (44)
APRIL (TNFSF13) regulates collagen‐induced arthritis, IL‐17 production and Th2 response (2008) (43)
Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes. (1989) (42)
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen (2015) (42)
A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas (2009) (41)
Membrane attach complex of complement (MAC): three-dimensional analysis of MAC-phospholipid vesicle recombinants. (1982) (41)
Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 (2015) (41)
Loss of the Perforin Cytotoxic Pathway Predisposes Mice to Experimental Cytomegalovirus Retinitis (2003) (41)
Perforin: structure, function, and regulation. (1992) (40)
Cytokine and cytotoxic pathways of NK cell rejection of class I-deficient bone marrow grafts: influence of mouse colony environment. (1998) (40)
CD30 Ligand Is a Target for a Novel Biological Therapy against Colitis Associated with Th17 Responses (2010) (40)
Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation. (2017) (38)
Perforin and granzyme B as markers for acute rejection in heart transplantation. (1991) (37)
Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer. (1995) (37)
Tumor antigen specific iTreg accumulate in the tumor microenvironment and suppress therapeutic vaccination (2012) (37)
Molecular and Cellular Requirements for Enhanced Antigen Cross-Presentation to CD8 Cytotoxic T Lymphocytes1 (2007) (37)
IL‐18 is Present at the Maternal–Fetal Interface and Enhances Cytotoxic Activity of Decidual Lymphocytes (2002) (36)
Structure, Function and Expression of Murine and Human Perforin 1 (P1) (1988) (36)
Bcl-2 protects against Fas-based but not perforin-based T cell-mediated cytolysis. (1996) (36)
Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways. (2005) (36)
The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex. (1976) (36)
REVIEW ARTICLE: Secreted Heat Shock Protein gp96‐Ig: An Innovative Vaccine Approach (2008) (35)
Membrane attack complex of complement: distribution of subunits between the hydrocarbon phase of target membranes and water. (1981) (35)
Humanized mice: novel model for studying mechanisms of human immune-based therapies (2013) (35)
Regulatory T Cell–Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9 (2017) (34)
Isolation and characterization of cytotoxic granules from human lymphokine (interleukin 2) activated killer cells. (1988) (33)
Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study (2016) (33)
Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas. (1999) (33)
Cell-secreted Gp96-Ig-peptide complexes induce lamina propria and intraepithelial CD8+ cytotoxic T lymphocytes in the intestinal mucosa (2010) (32)
T Cell Costimulation by TNFR Superfamily (TNFRSF)4 and TNFRSF25 in the Context of Vaccination (2012) (32)
Cytolytic cell functions (1997) (32)
CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice (2013) (31)
Small cell lung carcinomas express shared and private tumor antigens presented by HLA-A1 or HLA-A2. (1999) (30)
MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections. (2017) (30)
Impaired nonrestricted cytolytic activity in systemic lupus erythematosus: involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP that is associated with little detectable perforin. (1997) (30)
Structure and function of the murine perforin promoter and upstream region. Reciprocal gene activation or silencing in perforin positive and negative cells. (1992) (30)
Membranolysis by the ninth component of human complement. (1981) (30)
RESISTANCE AND SUSCEPTIBILITY OF NEURAL CELLS TO LYSIS BY CYTOTOXIC LYMPHOCYTES AND BY CYTOLYTIC GRANULES (1992) (29)
Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen (2016) (29)
Cellular localization of perforin 1 in murine cloned cytotoxic T lymphocytes. (1987) (29)
Immunobiology of TNFSF15 and TNFRSF25 (2013) (29)
Soluble and membrane-bound TNF-alpha are involved in the cytotoxic activity of B cells from tumor-bearing mice against tumor targets. (1994) (29)
Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients (2004) (28)
TNFRSF25 Agonistic Antibody and Galectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions (2012) (28)
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases (2013) (28)
Heat Shock Fusion Protein gp96‐Ig Mediates Strong CD8 CTL Expansion in vivo (2002) (28)
Increased perforin expression in multiple sclerosis patients during exacerbation of disease in peripheral blood lymphocytes (1997) (27)
Short‐term Cytolytic Mediators’ Expression in Decidual Lymphocytes is Enhanced by Interleukin‐15 (2006) (26)
Faculty Opinions recommendation of The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. (2005) (26)
CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. (1996) (26)
Induction of CD8 T-cell-Ifn-γ response and positive clinical outcome after immunization with gene-modified allogeneic tumor cells in advanced non-small-cell lung carcinoma (2003) (26)
Bcl10 expression, rearrangement and mutation in MALT lymphoma: correlation with expression of nuclear factor-kappaB. (2001) (26)
Transgenic control of perforin gene expression. Functional evidence for two separate control regions. (1995) (25)
Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease. (1998) (25)
A “Minimal Signal‐Stepwise Activation” Analysis of Functional Maturation of T Lymphocytes (1989) (25)
How to induce involuntary suicide: the need for dipeptidyl peptidase I. (1999) (24)
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa. (2011) (23)
Limited proteolysis of C5b-6: functional stability of the degraded complex. (1980) (23)
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. (2007) (22)
Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer Proteins (2016) (22)
Structure and function of perforin. (1989) (22)
Faculty Opinions recommendation of Systemic control of plasmacytoid dendritic cells by CD8+ T cells and commensal microbiota. (2008) (22)
Cytolytic lymphocytes and complement : effectors of the immune system (2017) (21)
Down‐Regulated Expression of Perforin‐Positive/CD16+ Cells in the Peripheral Blood Lymphocytes in the First Trimester of Pregnancy and Up‐Regulation at the End of Pregnancy (1997) (21)
Membrane attack complex of complement. Evidence for its dimeric structure based on hybrid formation. (1981) (21)
Systemic and local expression of perforin in lymphocyte subsets in acute and chronic rheumatoid arthritis. (2003) (20)
CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing γδ T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guérin Infection (2013) (19)
Loss of Intra‐Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV‐Infected Women (2016) (19)
The role of TNFRSF25:TNFSF15 in disease… and health? (2011) (19)
Function of granule perforin and esterases in T cell-mediated reactions. Components required for delivery of molecules to target cells. (1988) (19)
Phase I study of transfected cancer cells expressing the interleukin-2 gene product in limited stage small cell lung cancer. (1995) (19)
Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96 (2007) (18)
Granule-mediated cytolysis of target cells. (1989) (18)
Generation of tumor-specific cytotoxic T lymphocytes by stimulation with HPV type 16 E7 peptide-pulsed dendritic cells: an approach to immunotherapy of cervical cancer. (1999) (17)
Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors. (2014) (17)
Gene therapy for Lewis lung carcinoma with tumor necrosis factor and interleukin 2 cDNAs co-transfected subline. (1994) (17)
Cytotoxic Effector Mechanisms (1989) (16)
Cytolytic T-cell granules: biochemical properties and functional specificity. (1985) (16)
CD30 Ligand/CD30 Interaction Is Involved in Pathogenesis of Inflammatory Bowel Disease (2012) (16)
Pore formers of the immune system. (2007) (16)
Perforin‐Deficient T Cells Can Induce Acute Graft‐versus‐Host Disease after Transplantation of MHC‐Matched or MHC Disparate Allogeneic Bone Marrow (1995) (15)
Perforin, killer cells and gene transfer immunotherapy for cancer. (1995) (15)
CD30 ligand is a new therapeutic target for central nervous system autoimmunity. (2015) (15)
Self-association of the seventh component of human complement (C7): dimerization and polymerization. (1985) (14)
CD30 supports lung inflammation. (2008) (14)
Impaired nonrestricted cytolytic activity in systemic lupus erythematosus : Involvement of a pathway independent of Fas, tumor necrosis factor, and extracellular ATP that is associated with little detectable perforin (1997) (14)
Primary sequence homology between the effector molecules that mediate complement and T-lymphocyte cytotoxicity. (1987) (14)
Severe intrahepatic cholestasis in patients treated with recombinant interleukin-2 and lymphokine-activated killer cells (2004) (13)
Assembly and Functions of the Terminal Components (1986) (13)
CD8 T cell response in a phase I study of therapeutic vaccination of advanced NSCLC with allogeneic tumor cells secreting endoplasmic reticulum-chaperone gp96-Ig-peptide complexes * (2013) (13)
Human decidual lymphocytes: Phenotype, perforin expression, and function (1994) (13)
In vitro and in vivo growth of B16F10 melanoma cells transfected with interleukin-4 cDNA and gene therapy with the transfectant (2005) (12)
Multiple Low-Dose Challenges in a Rhesus Macaque AIDS Vaccine Trial Result in an Evolving Host Response That Affects Protective Outcome (2014) (12)
An Essential Role for Perforin-2 in Type I IFN Signaling (2020) (12)
Killer lymphocytes and how they kill. (1989) (11)
Fas and Perforin Cytotoxic Pathways Are Not the Major Effector Mechanisms in Allogeneic Resistance to Bone Marrow (1995) (11)
Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation. (2002) (11)
Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. (2014) (11)
Gene transfer of the CD80 costimulatory molecule into ocular melanoma cells using a novel episomal vector. (1997) (10)
Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines (2005) (10)
Transgenic control of perforin gene expression (1995) (10)
CD40‐CD40L interactions provide “third‐party” costimulation for T cell response against B7‐1‐transfected human breast tumor cells (1997) (10)
Present and future of lung cancer vaccines (2006) (10)
DONOR T CELLS WHICH CANNOT MEDIATE PERFORIN DEPENDENT AND FASL-DEPENDENT CYTOTOXICITY CAN EFFECT GRAFT VS. HOST REACTIVITY FOLLOWING ALLOGENEIC BONE M ARROW TRANSPLANTATION (1998) (10)
Statistical Considerations in Clinical Trial Design of Immunotherapeutic Cancer Agents. (2015) (10)
Structure of perforin and its role in cytolysis. (1989) (10)
Determination of the number of lytic sites in biconcave and spheroid erythrocyte ghosts after complement lysis. (1979) (8)
The use of real-time PCR and fluorogenic probes for rapid and accurate genotyping of newborn mice. (2001) (8)
The membrane attack complex of complement and its precursor proteins lack phospholipase activity. (1983) (8)
Cellular interactions in hemopoiesis. (1987) (7)
Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA. (2003) (7)
T-cell Mediated Cytotoxicity (1993) (5)
Increased cytotoxicity and CD16 (Leu 11) expression in long-term, IL-2-activated human peripheral blood mononuclear cells. (1987) (5)
Advances in Tumor Immunology and Immunotherapy (2014) (5)
Impaired B Cell Function in Mice Lacking Perforin-2 (2020) (4)
in Vitro characterization of hammerhead ribozymes against perforin and fas-Ligand RNA (1996) (4)
Cytolytic Lymphocytes and Complement Effectors of the Immune System: Volume 1 (1988) (4)
Abrogation of Graft‐versus‐Host Disease Following Allotransplantation of Cytotoxically Deficient Bone Marrow across Major Histocompatibility Barriers (1995) (4)
SC5b-9: Regeneration of the Ability to Interact with Lipid by Selective Removal of the S-Protein (1978) (3)
Erythropoiesis in cancer patients undergoing immunotherapy. (1989) (3)
Molecular Events in Late Stages of T‐Cell Functional Maturation (1992) (3)
Cytokines and hormones in the regulation of perforin expression in the decidual lymphocytes (1998) (3)
Interleukin 2 therapy for disseminated cancer. (1987) (3)
Small Cell Lung Carcinomas Express Shared and Private Tumor Antigens Presented by HLA-A 1 or HLA-A 21 (1999) (3)
Prognostic Value of Bcl 10 Rearrangement in Diffuse Large B-cell Lymphoma (2002) (3)
How to polymerize in order to survive. (2009) (3)
CD 30 Ligand Is a Target for a Novel Biological Therapy against Colitis Associated with Th 17 Responses (2010) (2)
Perforin, FasL, TNFR1, TWEAK, TRAIL, and DR3-TL1a are not required for efficient T cell mediated resistance against allogeneic bone marrow grafts (2004) (2)
Corrigendum to distinct transcriptomic features are associated with transitional and mature B-cell Populations in the mouse spleen [Front Immunol (2015) 6, 30], DOI: 10.3389/fimmu.2015.00030 (2016) (2)
Marked in vivo Donor Treg Expansion via IL-2 and TL1A-Ig stimulation ameliorates GVHD but preserves GVL in recipients post-HSCT (2017) (2)
Author response: Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria (2015) (2)
Natural killer cytolytic activity (2010) (2)
Combining Early Heat Shock Protein Vaccination with Directed IL-2 Leads to Effective Anti-Tumor Immunity in Autologous Hematopoietic Cell Transplantation Recipients (2011) (2)
Secreted heat shock protein gp96-Ig vaccine for malaria prophylaxis (2016) (2)
C5b-8 mediated and spontaneous polymerization of C9: Formation of C9 polymers with ultrastructural resemblance of the membrane attack complex (MAC) (1982) (2)
Lymphocyte‐Mediated Cytotoxicity (2010) (2)
Chapter 14 Perforin and the Mechanism of Lymphocyte-Mediated Cytolysis (1990) (2)
Suppression of the anti-erythrocyte immune response in mice by the C5b--9 complex of complement. (1981) (2)
Interaction of progesterone and IL15 in the regulation of perforin expression and cytolytic activity of decidual lymphocytes at the maternofetal interface (2002) (1)
Detection of perforin in human peritoneal fluid T-lymphocytes. (1996) (1)
Proposal for Classification of Leukocyte‐Associated Cytolytic Molecules: Denver, Colorado, September 28, 1986 (1987) (1)
Cytolytic lymphocyte granules: content of a pore forming protein (perforin 1) and homology to C9 (1988) (1)
Immunology and microbiology in Miami (2013) (1)
Induction of tumor immunity by gp96 secreted from engineered tumor cells (2000) (1)
Pathway Programmed Cell Death Via a Bcl-2-Sensitive Selection in the Thymus and Mediates CD 30 Overexpression Enhances Negative (1999) (1)
Response to Taraban, Ferdinand, and Al-Shamkhani (2011) (1)
Secreted heat shock protein gp96-Ig vaccine induces malaria specific intrahepatic CD8 T cell responses (2020) (1)
Quantitation of the membrane attack complex of complement in an air-driven ultracentrifuge. (1979) (1)
Characterisation of antigen presenting cells in the human first trimester decidua (2002) (1)
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases (2013) (1)
TL1A-Ig induces transplantation tolerance (P1003) (2013) (1)
Deviated Lysis: Formation of a Properdin Stabilized C3/C5 Convertase As the Active Principle Underlying the Phenomenon (1978) (1)
Differentiated T Regulatory Cells Terminally + Development of Klrg 1 IL-2 Receptor Signaling Is Essential for the Podack (2012) (1)
Long-Term Growth and Expansion of Ril-2 Activated Nk- Cells for Cancer Therapy (2018) (0)
CD30L null SJL mice exhibit reduced lymph node and spleen weights but support growth of transplantable SJL lymphoma RCS-X (48.29) (2011) (0)
CD8 T Cell Expansion Early Post-Autologous HSCT Following Vaccination with Lymphoma Cells Secreting gp96-Ig and Augmentation by IL-2 Antibody Cytokine Complex (2010) (0)
TNFRSF25 agonists as potent cancer vaccine adjuvants (131.25) (2010) (0)
Characerization of a novel pore‐forming protein in macrophages (2008) (0)
A method for the in vivo proliferation of regulatory T-cells (2010) (0)
TNFRSF25 promotes Th2 polarization after CD28 costimulation (2008) (0)
Tumor Antigens Presented by HLA-A 1 or HLA-A 2 Small Cell Lung Carcinomas Express Shared and Private Updated (1999) (0)
TNFR25 Expression on CD4 + CD25 + T Cells: Down Modulation of Regulatory Activity. (2006) (0)
The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success (2013) (0)
Perforin- expressing lymphocytes in peripheral blood and decidua of normal and pathological pregnancies (1994) (0)
NSG-hu mice generate HIV specific human immune responses after gp96 vaccination (46.14) (2010) (0)
This information is current as Dependent on Galectin-9 Inflammation Induced by DR 3 Signaling Is Mediated Suppression of − Regulatory T Cell (2017) (0)
In vitro cultivation of human decidual granulated leucocytes exerts a significant changes in expression of cell mediated cytotoxicity-related molecules (2017) (0)
CD30: from basic research to cancer therapy (2013) (0)
Membrane attack complex of complement subunit distribution of hydrophobic domains probed with photo affinity labeled phospho lipids (1980) (0)
Heat shock protein Gp96-Ig-peptide complexes based vaccine induce predominant immune responses at mucosal sites (46.13) (2010) (0)
Targeting the IL-2/CD25 and TL1A/TNFRSF25 Pathways: A New Approach to Markedly Expand Donor Tregs in Multiple Compartments Leads to in Situ Immune Regulation (2015) (0)
Graft-versus-Host Disease T Cell-Mediated + Regulates CD4 CD30/CD30 Ligand (CD153) Interaction (2004) (0)
Cloning of murine CD30 interacting protein genes (1996) (0)
Up-regulation of perforin protein expression in peripheral blood and decidual lymphocytes co-cultivated with decidual macrophages (2019) (0)
Heat shock protein gp96 : modulates innate immune response at the materno-fetal interface (2004) (0)
Abstract A38: T cell costimulation by TNFRSF4, TNFRSF18, and TNFRSF25 in the context of vaccination. (2013) (0)
Based immunotherapy cancer cells allogenic (2009) (0)
CD30 mediates thymic Programmed Cell Death (PCD) through a BCL-2 sensitive pathway (1998) (0)
Different treatment of dendritic cells as antigen presenting cells in generation of tumor specific cytotoxic T lymphocytes against cervical cancer (1999) (0)
The modified heat shock protein / peptide antigen complex (1999) (0)
M17-01: Immunotherapy for lung tumors (2007) (0)
Expression and Purification of native TL1A (TNFSF15) to generate TL1A Aptamers. (2008) (0)
Novel tumor vaccine gp96-Ig fusion heat shock protein in advanced non-small cell lung cancer (NSCLC) patients who have failed palliative chemotherapy and erlotinib. (2010) (0)
Evolving Host Response that affects Protective Outcome (2014) (0)
Faculty Opinions recommendation of Granzyme B activity in target cells detects attack by cytotoxic lymphocytes. (2007) (0)
Mechanism of formation of membrane lesions by killer lymphocytes (1984) (0)
Corrigendum: Distinct Transcriptomic Features Are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen (2016) (0)
TNFRSF25 promotes IL-17 and TL1A expression in murine CD4+ T cells (96.10) (2009) (0)
TNFR25SF AND GALECTIN-9 COMBINATION THERAPY REDUCES HERPES SIMPLEX VIRUS-1 INDUCED STROMAL KERATITIS BY EXPANDING REGULATORY T CELLS AND REDUCING PATHOGENIC TH1 CELLS (170.17) (2012) (0)
Perforin expression in peripheral blood lymphocytes (PBL) in kidney transplant recipients (2017) (0)
Complement mediated killing of neisseria (1982) (0)
Membranolysis by isolated C9 in the absence of other complement proteins (1982) (0)
Abstract 754: Heat shock protein vaccines for immunotherapy ofHer-2/neu positive breast cancers (2011) (0)
Molecular and Cellular Requirements for Enhanced Antigen Cross-Presentation to CD 8 Cytotoxic T Lymphocytes 1 (2007) (0)
Mechanism of Lymphocyte-Mediated Tumor Cell Lysis (1988) (0)
Proliferation and Apoptosis Trafficking Signals, and Signals for Cytotoxic Effector Molecules, Lymphocyte CD30 Signals Integrate Expression of (2000) (0)
Boosting anti-tumor immunity by combining gp96-Ig vaccination and Ig-mTL1A fusion protein (131.33) (2010) (0)
Immunobiology of TNFSF15 and TNFRSF25 (2013) (0)
Membrane attack complex of comp affinity phospholipid binding sites 1 of five hydrophilic plasma proteins (transmembrane channel/protein-phospholipid micelles/mechar (2017) (0)
Gp96-Ig DNA transfer into muscle by electroporation induces antigen specific cellular immune responses (VAC12P.1027) (2014) (0)
Focus on Complement 40 December 2015 corrected (2015) (0)
In Situ Manipulation of Tregs Via Combined IL-2 and TNFRSF25 Signaling Pre- and Post-Transplant: A Novel Approach to Regulate GVHD By Marked Expansion of CD4+Foxp3+ T Cells (2015) (0)
HLA A2 restricted HIV specific mucosal and systemic immunity induced with secreted heat shock protein gp96‐Ig (2008) (0)
Characterization of TL1A-Ig Cloning, Expression, and Functional (0)
Human Lymphokine ( Interleukin 2 ) Activated Killer Cells Isolation and Characterization of Cytotoxic Granules from Updated (2006) (0)
Polymerization of the ninth compo Formation of poly(C9) with a tubul the membrane attack complex of c, (protein-protein interactions/protein-phospholipid interactions/prot (2016) (0)
Signaling in the Generation of Long-Lived A Novel Role of CD30/CD30 Ligand (2005) (0)
Killing machines: three pore-forming proteins of the immune system (2013) (0)
Secretory Heat Shock Protein - gp96-Ig Chaperoned Her-2/New Vaccines (1999) (0)
Enhanced cardiac allograft survival by TNFRSF25 expanded natural Treg cells in an allogeneic mouse model (169.9) (2011) (0)
Th17 Differentiation in Mice CD30 Ligand/CD30 Plays a Critical Role in (0)
NSG-hu mice generate antigen specific human immune responses after gp96 vaccination (161.9) (2010) (0)
TNFRSF25 mediated in vivo expansion of regulatory T-cells reduces immunopathology in a chronic model of allergic lung inflammation (55.4) (2011) (0)
LPS modifications and AvrA activity of Salmonella enterica serovar Typhimurium are required to prevent Perforin-2 expression by infected fibroblasts and intestinal epithelial cells. (2021) (0)
Polymerization of C7: Formation of amphiphilic poly C7 and its relation to insertion of met astable C5b-7 into phosphilipid bilayer membranes (1982) (0)
Galectin-9 Controls the Activity of DR3 (TNFRSF25) in Suppressing Immunity (2016) (0)
Abstract 5029: Comparative combination cancer immunotherapy with vaccination, checkpoint inhibition and TNFRSF stimulation (2014) (0)
Expression of Perforin-2 is regulated via transcriptional and translational mechanisms (52.18) (2007) (0)
Small Cell Lung Carcinomas Express Shared and Private Tumor Antigens Presented by HLA-A 1 or HLA-A 2 1 (1999) (0)
Abstract A24: Cancer-testis antigen expression is shared among gynecological tumors (2015) (0)
Faculty Opinions recommendation of Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. (2005) (0)
Advances in the Development of Lung Cancer Vaccines (2007) (0)
Induction of mucosal immunity by hsp gp96 (2007) (0)
In vivo Treg expansion by TNFRSF25 stimulation inhibits allergic lung inflammation (97.11) (2010) (0)
Powerful mucosal immune response in macaques (Macaca mulatta) in response to SIV gp96-Ig immunization (39.35) (2009) (0)
Adoptively transferred tumor-specific T cells expanded ex vivo using HSV amplicons encoding 4-1BBL persist in the host and demonstrate anti-tumor activity in vivo. (88.11) (2007) (0)
Herpesvirus-associated Lymphomas Induce Apoptosis in α Azidothymidine and Interferon-Updated Version (1999) (0)
Induction of mucosal immunity by hsp gp96 (41.2) (2007) (0)
Mycobacterial Infection T-T Cell Interaction in Th1 Response against A Novel Role of CD30L/CD30 Signaling by (2008) (0)
Novel function of perforin in control of lymphocyte regulatory function and proliferation (1996) (0)
Control of Treg by TNFRSF25 (2010) (0)
Expression and functional analysis of murine ÇD30 (1996) (0)
Marked In Vivo Expansion of Donor T Regulatory Cells Via Targeting of the IL-2/CD25 and TL1A/TNFRSF25 Pathways Elicits Gender Differences and Ameliorates Gvhd (2016) (0)
Perforin-2 Expression in Fibroblasts is Upregulated during dsRNA Stimulation. (52.12) (2007) (0)
Abstract A32: Combining early heat shock protein vaccination with directed IL-2 leads to effective and persistent antitumor immunity in recipients of experimental autologous hematopoietic cell transplantation. (2013) (0)
Molecular mechanisms of cell mediated cytotoxicity in early pregnancy (2002) (0)
Cancer testis-antigen expression shared among gynecological cancers (2015) (0)
Isolation and Characterization of Cytotoxic Granules from Human Lymphokine ( Interleukin 2 ) Activated Killer Cells 1 (2006) (0)
Morphological damage induced by isolated cytolytic granules in K562 target cells. (1992) (0)
The Role of T Cell Costimulation by CD80 in the Immune Response to Human Waldenstrom’s Macroglobulinemia. (2006) (0)
TNFRSF)4 and TNFRSF25 in the Context T Cell Costimulation by TNFR Superfamily (2012) (0)
O-152 Immunotherapy with gene-modified allogenic cells successfully induced CD8 T cell and clinical responses in patients with advanced non-small cell lung cancer (NSCLC) (2003) (0)
DAMD 1798-1-8317 TITLE : Secretory Heat Shock Protein-gp 96-Ig Chaperoned her-2 / new Vaccines (0)
A New Family of Pore Forming Proteins, the Perforin Family, in Immune Cytolysis by Complement and by Lymphocytes (1988) (0)
Properties and Function of Cytolytic Lymphocyte Granules (2018) (0)
Humanized mice: novel model for studying mechanisms of human immune-based therapies (2013) (0)
Compositions and methods for treating inflamed lung disease (2004) (0)
Author response: Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 (2015) (0)
Control of Cytotoxic Lymphocyte Survival in Vivo By Members of the TNF-R Family (2001) (0)
Complexe peptide antigenique/proteine du stress modifiee (1999) (0)
Faculty Opinions recommendation of Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. (2003) (0)
Immunotherapy by intra-peritoneal intra-peritoneal injection of interleukin-2 gene transduced ling cancer cell line. (1994) (0)
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection (2014) (0)
Differentiated T Regulatory Cells Terminally + Development of Klrg1 IL-2 Receptor Signaling Is Essential for the (2012) (0)
Immunomodulation of agonists, antagonists and immunotoxins receptor tumor necrosis factor 25 (TNFR25) (2006) (0)
Combined absence of perforin and FasL in perf -/- x gld mice significantly decreases anti-CD3 induced enteropathy (2000) (0)
B cell regulation of anti-tumor immune response (2013) (0)
Cytotoxic T Lymphocytes CD 8 Enhanced Antigen Cross-Presentation to Molecular and Cellular Requirements for and (2007) (0)
APRIL (TNFSF13) Promotes Collagen Induced Arthritis and IL‐17 Production and Inhibits IFN‐gamma and IL‐4 Production (2008) (0)
Perforin and granzyme B as markers for acute rejection in heart transplantation (1991) (0)
TNFRSF25 agonists as potent cancer vaccine adjuvants (2010) (0)
Soluble CD30 Levels Are Highest in Autoimmune Hemolytic Anemia (AIHA) and Lymphoma among the Hematologic Disorders, but Are Not Elevated in ITP. (2004) (0)
Role of co-stimulation in Mtv29 superantigen induced V-beta-16 T cell responses to SJL lymphomas (1997) (0)
Control of Treg by TNFRSF25 (49.12) (2010) (0)
Heat shock protein Gp96-Ig-peptide complexes based vaccine induce predominant immune responses at mucosal sites (2010) (0)
Formation of membrane lesions (poly perforins) by cloned tk cells on tumor target membranes. Abstr. (1983) (0)
Cloning and Analysis of Perforin 1 cDNA (1989) (0)
Erratum: Resistance and susceptibility of neural cells to lysis by cytotoxic lymphocytes and by cytotoxic granules (Transplantation (522)) (1992) (0)
Combining gp96-Ig vaccination and mTL1A-Ig fusion protein boosts anti-tumor immunity. (165.10) (2011) (0)
Faculty Opinions recommendation of Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. (2005) (0)
Marked in vivo Donor Treg expansion via targeting of the IL-2/CD25 and TL1A/TNFRSF25 pathways ameliorates GVHD and preserves GVL (2017) (0)
Soluble CD30 (sCD30), a Marker of Th2 Polarization, Is Elevated in Patients with Autoimmune Hemolytic Anemia (AIHA) but Not with Idiopathic Thrombocytopenia (ITP). (2005) (0)
Three dimensional analysis of the membrane attack complex of complement recombined with phospholipid vesicles (1982) (0)
Kinase-DependentMitogen-Activated Protein Receptor-Associated Factor / p 38 Induces IL-13 Production Via a TNF TCR-Independent CD 30 Signaling Selectively (2002) (0)
Abstract 4769: Relevance of the TRIF pathway for in vivo gp96-mediated CD8+ T cell cross presentation (2010) (0)
Comparative combination cancer immunotherapy with vaccination, checkpoint inhibition and TNFRSF stimulation (VAC12P.1021) (2014) (0)
Immunology and microbiology in Miami (2013) (0)
Abstract LB-164: B lymphocytes inhibit anti-tumor response in a murine EMT6 tumor model by facilitating expansion of T regulatory cells (2011) (0)
CD30 costimulation is required for negative selection in the thymus (1996) (0)
Properties of Transmembrane Channels Induced by Cytolytic Lymphocytes (2018) (0)
Heat shock fusion protein gp96-Ig induces activation of innate and adaptive immunity (2002) (0)

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