Edgar Pick
#81,858
Most Influential Person Now
Israeli immunologist
Edgar Pick's AcademicInfluence.com Rankings
Edgar Pickbiology Degrees
Biology
#6581
World Rank
#9331
Historical Rank
Immunology
#583
World Rank
#602
Historical Rank
Download Badge
Biology
Edgar Pick's Degrees
- PhD Immunology Weizmann Institute of Science
- Bachelors Biology Tel Aviv University
Similar Degrees You Can Earn
Why Is Edgar Pick Influential?
(Suggest an Edit or Addition)According to Wikipedia, Edgar Pick is an Israeli immunologist who is Professor Emeritus of Immunology in the Department of Clinical Microbiology and Immunology at the Faculty of Medicine at Tel Aviv University, Israel. Early life and education Pick was born in 1938 in Lugoj, Romania. After receiving his baccalaureate at the Coriolan Brediceanu High School in Lugoj, he enrolled at the Victor Babeș University of Medicine and Pharmacy. He completed his medical studies at the Hebrew University Hadassah Medical School in Jerusalem, graduating with an M.D. in 1965. He was a postdoctoral fellow in experimental pathology at the Scripps Clinic and Research Foundation in La Jolla, California, from 1965 to 1967, where he trained with Joseph D. Feldman. In 1967 he joined the laboratory of John L.Turk, the world leader of cell-mediated immunity studies. He received a Ph.D. from the University of London in 1970. While in London, Pick focused on the study of soluble products made by antigen-stimulated T lymphocytes—known as lymphokines, and later as a form of cytokines—characterizing molecules known as "skin reactive factor" and "migration inhibitory factor". With Turk, he published one of the first reviews on lymphokines.
Edgar Pick's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. (1981) (1120)
- A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. (1980) (1093)
- Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1 (1991) (936)
- Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages--induction by multiple nonphagocytic stimuli. (1981) (477)
- Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate. (1985) (295)
- Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages. (1984) (280)
- Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader. (1986) (243)
- Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. (1998) (220)
- Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds* (1997) (205)
- The Cytosolic Component p47phox Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production* (1996) (154)
- Unsaturated fatty acids as second messengers of superoxide generation by macrophages. (1983) (142)
- Targeting of Rac1 to the Phagocyte Membrane Is Sufficient for the Induction of NADPH Oxidase Assembly* (2000) (130)
- Dual Role of Rac in the Assembly of NADPH Oxidase, Tethering to the Membrane and Activation of p67phox (2004) (125)
- The biological activities of soluble lymphocyte products. (1972) (121)
- Interaction between 'sensitized lymphocytes' and antigen in vitro. I. The release of a skin reactive factor. (1969) (106)
- Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex. (2001) (93)
- Mapping of Functional Domains in the p22 phox Subunit of Flavocytochrome b 559 Participating in the Assembly of the NADPH Oxidase Complex by “Peptide Walking”* (2002) (89)
- Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Absolute lipid dependence of the solubilized enzyme. (1989) (88)
- The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559. (1991) (87)
- Generation of Superoxide by purified and relipidated cytochrome b 559 in the absence of cytosolic activators (1993) (86)
- Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase (2014) (79)
- G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction. (2011) (77)
- Interaction between “sensitized lymphocytes” and antigen in vitro: II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors (1970) (75)
- A rapid densitometric microassay for nitroblue tetrazolium reduction and application of the microassay to macrophages. (1981) (74)
- Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure‐function relationships (2006) (70)
- A Prenylated p67 phox -Rac1 Chimera Elicits NADPH-dependent Superoxide Production by Phagocyte Membranes in the Absence of an Activator and of p47 phox (2002) (68)
- Functional melatonin receptors in human prostate epithelial cells. (1996) (67)
- Activation of the superoxide forming NADPH oxidase in a cell-free system by sodium dodecyl sulfate. Characterization of the membrane-associated component. (1987) (66)
- The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages. (1994) (64)
- Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages. (1991) (64)
- " Peptide Walking" Is a Novel Method for Mapping Functional Domains in Proteins (1995) (64)
- Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1. (2001) (63)
- Superoxide production by cytochrome b559. Mechanism of cytosol-independent activation. (1994) (63)
- Cyclic AMP affects macrophage migration. (1972) (61)
- Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase. (1998) (60)
- Inhibition of NADPH oxidase activation by synthetic peptides mapping within the carboxyl-terminal domain of small GTP-binding proteins. Lack of amino acid sequence specificity and importance of polybasic motif. (1994) (59)
- Interaction between "sensitized lymphocytes" and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors. (1970) (57)
- Electron transfer in the superoxide-generating NADPH oxidase complex reconstituted in vitro. (1997) (57)
- Activation of the Phagocyte NADPH Oxidase by Rac Guanine Nucleotide Exchange Factors in Conjunction with ATP and Nucleoside Diphosphate Kinase* (2005) (54)
- Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. (2012) (53)
- Mapping of Functional Domains in p47 phox Involved in the Activation of NADPH Oxidase by “Peptide Walking”* (1998) (49)
- Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase. (2007) (49)
- Dissociation of Rac1(GDP)·RhoGDI Complexes by the Cooperative Action of Anionic Liposomes Containing Phosphatidylinositol 3,4,5-Trisphosphate, Rac Guanine Nucleotide Exchange Factor, and GTP* (2008) (47)
- Release of Skin Reactive Factor from Guinea-pig Lymphocytes by Mitogens (1970) (44)
- Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages. (1993) (43)
- Studies on the inhibition of macrophage migration induced by soluble antigen-antibody complexes. (1975) (41)
- Liposomes Comprising Anionic but Not Neutral Phospholipids Cause Dissociation of Rac(1 or 2)·RhoGDI Complexes and Support Amphiphile-independent NADPH Oxidase Activation by Such Complexes* (2006) (39)
- Blocking of macrophage migration inhibitory factor action by microtubular disruptive drugs. (1973) (38)
- Activation of the superoxide-forming NADPH oxidase of macrophages requires two cytosolic components--one of them is also present in certain nonphagocytic cells. (1989) (37)
- Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask". (2007) (36)
- The mechanism of action of soluble lymphocytic mediators. II. Modification of macrophage migration and migration inhibitory factor action by drugs, enzymes and cationic environment. (1974) (36)
- A Prenylated p47phox-p67phox-Rac1 Chimera Is a Quintessential NADPH Oxidase Activator (2010) (31)
- The mechanism of action of soluble lymphocyte mediators. IV. Effect of migratio inhibitory factor (MIF) on macrophage cyclic AMP and on responsiveness to adenylate cyclase stimulators. (1977) (30)
- The mechanism of action of soluble lymphocytic mediators. I. A pulse exposure test for the measurement of macrophage migration inhibitory factor. (1973) (27)
- Macrophage-derived superoxide-generating NADPH oxidase in an amphiphile-activated, cell-free system; partial purification of the cytosolic component and evidence that it may contain the NADPH binding site. (1988) (27)
- Cell-free NADPH oxidase activation assays: "in vitro veritas". (2014) (27)
- Tripartite Chimeras Comprising Functional Domains Derived from the Cytosolic NADPH Oxidase Components p47phox, p67phox, and Rac1 Elicit Activator-independent Superoxide Production by Phagocyte Membranes (2007) (26)
- Activation of the Superoxide‐Generating NADPH Oxidase of Macrophages by Sodium Dodecyl Sulfate in a Soluble Cell‐Free System: Evidence for Involvement of a G Protein (1990) (26)
- INTRACELLULAR MEDIATION OF LYMPHOKINE ACTION: MIMICRY OF MIGRATION INHIBITORY FACTOR (MIF) ACTION BY PHORBOL MYRISTATE ACETATE (PMA) AND THE IONOPHORE A23187 * (1979) (25)
- Epitope identification for human neutrophil flavocytochrome b monoclonals 48 and 449 (2000) (25)
- HETEROGENEITY OF ANTIBODY-FORMING CELLS AN ELECTRON MICROSCOPIC ANALYSIS (1969) (25)
- Cyclic GMP metabolism in macrophages. I. Regulation of cyclic GMP levels by calcium and stimulation of cyclic GMP synthesis by NO-generating agents. (1980) (24)
- Certain lymphoid cells contain the membrane-associated component of the phagocyte-specific NADPH oxidase. (1988) (23)
- Lymphokines: Physiologic Control and Pharmacological Modulation of Their Production and Action (1977) (23)
- Two Pathways of Activation of the Superoxide-Generating NADPH Oxidase of Phagocytes In Vitro—Distinctive Effects of Inhibitors (2003) (22)
- The Guanine Nucleotide Exchange Factor Trio Activates the Phagocyte NADPH Oxidase in the Absence of GDP to GTP Exchange on Rac (2003) (22)
- Soluble lymphocytic mediators. I. Inhibition of macrophage migration inhibitory factor production by drugs. (1974) (21)
- Enhancement of macrophage adenylate cyclase by microtubule disrupting drugs. (1978) (21)
- The mechanism of action of soluble lymphocyte mediators. V. Mechanism of refractoriness to adenylate cyclase stimulators induced by migration inhibitory factor (MIF). (1977) (20)
- Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides” (2012) (20)
- The mechanism of action of soluble lymphocyte mediators. VI. Effect of migration inhibitory factor (MIF) on macrophage microtubules. (1979) (20)
- Cytoskeletal control of concanavalin A receptor mobility in peritoneal macrophages. (1979) (20)
- The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox (2015) (19)
- Macrophage-mediated cytolysis off erythrocytes in the guinea pig. I. Activation by stimulators of the oxidative burst. (1981) (19)
- phox-Rac 1 Chimera Elicits NADPH-dependent Superoxide Production by Phagocyte Membranes in the Absence of an Activator and of p 47 phox CONVERSION OF A PAGAN NADPH OXIDASE TO MONOTHEISM (2002) (19)
- Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2‐A “peptide walking” study (2012) (19)
- Lymphokines : a forum for immunoregulatory cell products (1981) (19)
- A simple method for the production of migration inhibitory factor by concanavalin A - stimulated lymphocytes. (1977) (18)
- Role of transmethylation in the elicitation of an oxidative burst in macrophages. (1982) (17)
- Nucleotide binding properties of cytosolic components required for expression of activity of the superoxide generating NADPH oxidase. (1990) (16)
- Turning off NADPH oxidase-2 by impeding p67phox activation in infected mouse macrophages reduced viral entry and inflammation. (2018) (16)
- Mechanism of Action of Migration Inhibitory Lymphokines (1979) (14)
- The Lymphokine Concept (1979) (14)
- A Cys‐Gly‐Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox (2015) (14)
- Facilitation of adenylate cyclase stimulation in macrophages by lectins. (1979) (14)
- Activation of macrophage adenylate cyclase by stimulants of the oxidative burst and by arachidonic acid--two distinct mechanisms. (1981) (13)
- The mechanism of action of lymphokines. VIII. Lymphokine-enhanced spontaneous hydrogen peroxide production by macrophages. (1985) (13)
- The mechanism of action of lymphokines. IX. The enzymatic basis of hydrogen peroxide production by lymphokine-activated macrophages. (1986) (12)
- Erratum to: Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or ‘‘All that you did and did not want to know about Nox inhibitory peptides’’ (2012) (11)
- The mechanism of action of macrophage migration inhibitory factor (MIF). (1973) (11)
- Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b. (2007) (11)
- Interaction between 'sensitized lymphocytes' and antigen in vitro. IV. Studies on the mechanism of release of skin reactive and macrophage migration-inhibitory factors. (1972) (11)
- Lymphokine-related eosinophil responses. (1980) (10)
- Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox. (2014) (10)
- Renal homotransplantation in rats. II. Tolerant recipients. (1968) (9)
- Effect of tumor promoters in immunological systems--the macrophage as a target cell for the action of phorbol esters. (1982) (9)
- Interaction between 'sensitized lymphocytes' and antigen in vitro. V. Vascular permeability induced by skin-reactive factor. (1972) (8)
- Antigen and mitogen induced production of macrophage migration inhibitory factor in the mouse. (1979) (8)
- Binding of p67phox to Nox2 is stabilized by disulfide bonds between cysteines in the 369Cys‐Gly‐Cys371 triad in Nox2 and in p67phox (2018) (8)
- Cell-Free NADPH Oxidase Activation Assays: A Triumph of Reductionism. (2020) (8)
- Quo vadis macrophage activation--role of phospholipids in the elicitation of the oxidative burst in macrophages. (1982) (7)
- The mechanism of action of lymphokines. VII. Modulation of the action of macrophage migration inhibitory factor by antioxidants and drugs affecting thromboxane synthesis. (1983) (7)
- Does migration inhibitory factor (MIF) act by promoting tubulin polymerization (1976) (7)
- Editorial: When charge is in charge—“Millikan” for leukocyte biologists (2010) (7)
- Passive Agglutination Tests: Bismuth Tannate Test (1963) (6)
- Studies on guinea-pig macrophage migration inhibitory factor (MIF). I. Glycoprotein nature and net charge. (1979) (5)
- Interaction between 'sensitized lymphocytes' and antigen in vitro. 3. Release of soluble mediators by particulate antigen. (1972) (5)
- Vitamin A-induced Rejection of Autografts and Homografts (1965) (5)
- Transfer of cutaneous hypersensitivity to tuberculin in the guinea pig by gamma G2 from immunized donors. (1968) (5)
- Using Synthetic Peptides for Exploring Protein-Protein Interactions in the Assembly of the NADPH Oxidase Complex. (2019) (5)
- Nonlymphoid cells interacted with mitogens fail to elaborate macrophage migration inhibitory factor (MIF). (1978) (5)
- Absolute and Relative Activity Values in Assessing the Effect of NADPH Oxidase Inhibitors. (2015) (5)
- Localization of lymphocytes producing macrophage migration inhibitory factor in albumin density gradients (1973) (4)
- A dithiol/disulfide redox switch in the dehydrogenase region on Nox2 regulates the assembly of the superoxide-generating NADPH oxidase of phagocytes (2012) (4)
- Studies on guinea-pig macrophage migration inhibitory factor (MIF). II. Purification of MIF after treatment with reducing and denaturing agents. (1979) (4)
- p67phox binds to a newly identified site in Nox2 following the disengagement of an intramolecular bond—Canaan sighted? (2020) (4)
- Molecular Mechanisms in Lymphokine-Induced Macrophage Activation-Enhanced Production of Oxygen Radicals (1985) (4)
- Effect of Phytohemagglutinin on Hemolytic Plaque Formation by Rat Lymphoid Cells∗ (1968) (4)
- In vivo action of soluble mediators associated with cell-mediated immunity. (1971) (4)
- Regulation of Macrophage Function by Lymphokines Role of Membrane Phospholipids (1983) (3)
- Extrinsic regulation of macrophage function by lymphokines--effect of lymphokines on the stimulated oxidative metabolism of macrophages. (1982) (3)
- Macrophage Microtubules: An Optimized Method for the Assay of Tubulin Concentration and State of Polymerization in Macrophages (1984) (3)
- Biology of the Lymphokines (2013) (3)
- New approaches to the characterization and isolation of migration inhibitory factor (MIF) (1976) (3)
- Participation of immunoglobulin‐bearing lymphocytes in the production of macrophage migration inhibitory factor (1975) (3)
- Characterization of Ca2+-activated, phospholipid-dependent protein kinase C/protein kinase M in guinea pig peritoneal exudate macrophages. (1986) (3)
- 34 – IN VITRO PRODUCTION AND ASSESSMENT OF ACTIVITY OF SKIN REACTIVE FACTORS RELEASED BY LYMPHOID CELLS AND ASSOCIATED WITH CELLULAR IMMUNITY (1971) (2)
- The molecular basis of Rac‐GTP action—promoting binding of p67phox to Nox2 by disengaging the β hairpin from downstream residues (2021) (2)
- AN INDIRECT ANTIGLOBULIN TEST FOR THE DETECTION OF HEMAGGLUTININS AFTER SKIN TRANSPLANTATION. (1964) (2)
- p67phox‐derived self‐assembled peptides prevent Nox2 NADPH oxidase activation by an auto‐inhibitory mechanism (2020) (2)
- Alfred Froehlich; 1871-1953. (1953) (2)
- Release of skin reactive factor from guinea pig lymphocytes by mitogens (1970) (2)
- Activation of the superoxide forming NADPH oxidase in a macrophage-derived cell-free system by fatty acids and detergents. (1986) (2)
- Superoxide production by cytochrome b 559 (2)
- Biochemistry of Lymphokine Action on Macrophages Modulation of Macrophage Superoxide Production by Lymphokine (1984) (1)
- "In vivo" reactions induced by soluble mediators of cellular immunity. (1970) (1)
- ADRENALINE AND SCHIZOPHRENIA (1962) (1)
- HETEROGENEITY OF ANTIBODY-FORMING CELLS (1969) (1)
- Fibrin-clot Formation by Extracts of Rabbit-skin Homografts (1964) (1)
- Lymphokine reports : a forum for nonantibody lymphocyte products (1980) (1)
- Medical luminaries (2001) (1)
- Lymphokines in macrophage activation (1981) (0)
- X-RAY SENSITIVITY OF SARCOMAS (1964) (0)
- Oxidative metabolism of lymphokine-activated macrophages—Free fatty acids as second messengers of superoxide generation☆☆☆ (1982) (0)
- Biochemistry of Lymphokine Action on Macrophages (1984) (0)
- Cytoskeletal control of concanavalin a receptor mobility in macrophages (1979) (0)
- Enzymes and metabolic activity of phagocytes (1986) (0)
- DISSOCIATION OF Rac1(GDP) · RhoGDI COMPLEXES BY THE COOPERATIVE ACTION OF ANIONIC LIPOSOMES CONTAINING PtdIns(3,4,5)P 3 , Rac GUANINE NUCLEOTIDE EXCHANGE FACTOR, AND GTP* (2008) (0)
- Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides” (2012) (0)
- Mechanism of lymphokine (LK)-enhanced oxygen radical generation by macrophages (MPs)- sodium nitroprusside (SNP) causes switch from H2O2 to O2 production (1985) (0)
- Erratum to: Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or ‘‘All that you did and did not want to know about Nox inhibitory peptides’’ (2013) (0)
- Biochemical Mechanisms of Macrophage Activation by Lymphokines (1983) (0)
- Round Table Conference on Allergen Standardization (1971) (0)
- Prolonged survival of rabbit skin homografts following intratesticular implantation of donor testis. (1966) (0)
- Proceedings: Macrophage adenyl cyclase tachyphylaxis-a new property of migration inhibitory factor. (1975) (0)
- Proceedings: "In vitro" production of pharmacological agents resulting from the interaction between sensitized lymphocytes and tuberculin. (1971) (0)
This paper list is powered by the following services:
Other Resources About Edgar Pick
What Schools Are Affiliated With Edgar Pick?
Edgar Pick is affiliated with the following schools:
