Edith Graef Mcgeer
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Edith Graef Mcgeerbiology Degrees
Biology
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Neuroscience
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#271
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Biology
Edith Graef Mcgeer's Degrees
- PhD Neuroscience University of British Columbia
- Bachelors Biology University of British Columbia
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(Suggest an Edit or Addition)Edith Graef Mcgeer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains (1988) (2578)
- Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease (1996) (1396)
- The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases (1995) (1326)
- The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat (1981) (857)
- Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids (1976) (828)
- Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR (1987) (817)
- Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry (1983) (690)
- Kainic acid as a tool in neurobiology (1978) (682)
- Glial reactions in Parkinson's disease (2008) (664)
- Aging and extrapyramidal function. (1977) (662)
- Generation of C-reactive protein and complement components in atherosclerotic plaques. (2001) (625)
- Microglia in degenerative neurological disease (1993) (603)
- Inflammation and neurodegeneration in Parkinson's disease. (2004) (593)
- Rate of cell death in parkinsonism indicates active neuropathological process (1988) (560)
- Inflammation and the Degenerative Diseases of Aging (2004) (520)
- Molecular Neurobiology of the Mammalian Brain (1978) (496)
- Inflammation, autotoxicity and Alzheimer disease (2001) (492)
- NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies (2007) (491)
- Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain (1984) (478)
- ENZYMES ASSOCIATED WITH THE METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA (1976) (477)
- A glutamatergic corticostriatal path? (1977) (474)
- Inflammatory processes in amyotrophic lateral sclerosis (2002) (472)
- Immune System Response in Alzheimer's Disease (1989) (468)
- Anti-inflammatory drugs and Alzheimer disease (1990) (438)
- Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K (1990) (415)
- Activation of the classical complement pathway in brain tissue of Alzheimer patients (1989) (395)
- The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy (2013) (356)
- Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide (2001) (350)
- The importance of inflammatory mechanisms in alzheimer disease (1998) (339)
- Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. (1980) (336)
- Up-regulated production and activation of the complement system in Alzheimer's disease brain. (1999) (333)
- Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract (1978) (324)
- Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. (2010) (322)
- Inflammation in Parkinson's disease. (2001) (306)
- Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer’s disease (2000) (300)
- Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome. (1973) (292)
- On the source of GABA-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies. (1973) (288)
- Distribution of reduced‐nicotinamide‐adenine‐dinucleotide‐phosphate diaphorase‐positive cells and fibers in the cat central nervous system (1989) (287)
- Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat (1988) (283)
- Neostriatal choline acetylase and cholinesterase following selective brain lesions. (1971) (274)
- Inflammatory processes in Alzheimer's disease (2003) (273)
- Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs (1999) (249)
- Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. (2006) (242)
- Inflammation of the brain in Alzheimer's disease: implications for therapy (1999) (233)
- Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain (2001) (217)
- α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia (2008) (213)
- Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls (1983) (208)
- Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases (2010) (207)
- Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys (2006) (207)
- Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain (1997) (203)
- Therapeutic approaches to inflammation in neurodegenerative disease (2007) (200)
- Aging and brain enzymes. (1971) (198)
- Polymorphisms in inflammatory genes and the risk of Alzheimer disease. (2001) (196)
- Brain inflammation in Alzheimer disease and the therapeutic implications. (1999) (194)
- Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue (1992) (191)
- The nigrotectal projection: a biochemical and ultrastructural characterization (1978) (190)
- Inflammation, the complement system and the diseases of aging (2005) (187)
- Choline acetylase and glutamic acid decarboxylase in Huntington's chorea (1973) (187)
- Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide (2009) (185)
- Evidence for glutamic acid decarboxylase-containing interneurons in the neostriatum (1975) (178)
- LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines (2006) (173)
- Immunohistochemical localization of choline acetyltransferase containing neostriatal neurons and their relationship with dopaminergic synapses (1976) (164)
- Influence of noncholinergic drugs on rat striatal acetylcholine levels. (1974) (159)
- Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration. (1973) (158)
- Marked increase in cyclooxygenase-2 in ALS spinal cord (2001) (158)
- Human heart generates complement proteins that are upregulated and activated after myocardial infarction. (1998) (156)
- Neuroimmune Mechanisms in Alzheimer Disease Pathogenesis (1994) (155)
- Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years. (2016) (151)
- Cholinergic projections from the basal forebrain of rat to the amygdala (1982) (146)
- Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. (2009) (145)
- Neurons express proteins of the classical complement pathway in Alzheimer disease (1997) (144)
- Fine structural changes in the rat striatum after local injections of kainic acid (1977) (142)
- Distribution of choline acetyltransferase immunopositive structures in the rat brainstem (1989) (139)
- Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase. (1971) (138)
- Some characteristics of brain tyrosine hydroxylase. (1967) (138)
- Positron emission tomography and histopathology in Pick's disease (1987) (137)
- Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease (1986) (134)
- Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease (1994) (133)
- Choline acetyltransferase localization in the central nervous system by immunohistochemistry. (1974) (128)
- Alzheimer disease and neuroinflammation. (2000) (122)
- Early response of brain resident microglia to kainic acid-induced hippocampal lesions (1994) (118)
- Anti‐Inflammatory Drugs in the Fight against Alzheimer's Disease a (1996) (117)
- AXONAL TRANSPORT IN NIGRO‐STRIATAL AND NIGRO‐THALAMIC NEURONS: EFFECTS OF MEDIAL FOREBRAIN BUNDLE LESIONS AND 6‐HYDROXYDOPAMINE 1 (1972) (117)
- Positron emission tomography in patients with clinically diagnosed Alzheimer's disease. (1986) (116)
- Myelin degeneration in multiple system atrophy detected by unique antibodies. (1998) (115)
- Complement Components, but Not Complement Inhibitors, Are Upregulated in Atherosclerotic Plaques (2001) (110)
- Mechanisms of GABA release from human astrocytes (2011) (110)
- Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain (2000) (108)
- Expression of MRP14, 27E10, interferon-α and leukocyte common antigen by reactive microglia in postmortem human brain tissue (1994) (106)
- Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease (2002) (106)
- Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug Therapy (1992) (105)
- Lipid Peroxide Distribution in Brain and the Effect of Hyperbaric Oxygen (1983) (104)
- Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain (1991) (104)
- The role of the immune system in neurodegenerative disorders (1997) (102)
- Cyanocarbon Chemistry. I. Preparation and Reactions of Tetracyanoethylene (1958) (97)
- THE INHIBITORY ACTION OF 3‐HYDROXYTYRAMINE, GAMMA‐AMINOBUTYRIC ACID (GABA) AND SOME OTHER COMPOUNDS TOWARDS THE CRAYFISH STRETCH RECEPTOR NEURON * (1961) (97)
- Differential development of caudate enzymes in the neonatal rat. (1971) (96)
- Peroxidase-labeled lectin as a neuroanatomical tracer: evaluation in a CNS pathway (1980) (95)
- The Role of Anti-Inflammatory Agents in Parkinson’s Disease (2007) (95)
- Hydrogen sulfide‐releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation (2010) (95)
- THE DISTRIBUTION OF TRYPTOPHAN HYDROXYLASE IN CAT BRAIN (1968) (94)
- Innate immunity, local inflammation, and degenerative disease. (2002) (92)
- Reactions of the Immune System in Chronic Degenerative Neurological Diseases (1991) (92)
- High stability of mRNAs postmortem and protocols for their assessment by RT-PCR. (2001) (92)
- Age Changes in the Human for Some Enzymes Associated with Metabolism of Catecholamines, GABA and Acetylcholine (1975) (91)
- Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage (1992) (91)
- Neurotransmitters in the Basal Ganglia (1984) (90)
- Evidence on the cellular localization of adenyl cyclase in the neostriatum (1976) (90)
- Central Aromatic Amine Levels and Behavior: II. Serotonin and Catecholamine Levels in Various Cat Brain Areas Following Administration of Psychoactive Drugs or Amine Precursors (1963) (89)
- Inhibition of rat brain tryptophan hydroxylase by 6-halotryptophans. (1968) (88)
- Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease (1995) (87)
- Pathological proteins in senile plaques. (1994) (86)
- Synaptic Transmission in the Central Nervous System (1978) (83)
- 18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans (1990) (82)
- The pentraxins: possible role in Alzheimer’s disease and other innate inflammatory diseases (2001) (82)
- Postnatal changes of GABAergic and glutamatergic parameters. (1981) (81)
- Mechanisms of cell death in Alzheimer disease--immunopathology. (1998) (81)
- Distribution of glutamic acid decarboxylase in the brains of various mammalian species. (1970) (81)
- Glutamic acid decarboxylase in Parkinson's disease and epilepsy (1971) (79)
- Effects of Hydrogen Sulfide-releasing l-DOPA Derivatives on Glial Activation (2010) (79)
- Enhancement of immunoreactivity for NF-κB in human cerebral infarctions (1996) (79)
- 6‐[18F]fluoro‐L‐DOPA PET studies of the turnover of dopamine in MPTP‐induced parkinsonism in monkeys (1998) (78)
- Electrophysiological properties of cortically projecting histamine neurons of the rat hypothalamus (1987) (77)
- Transmitters contained in the efferents of the habenula (1980) (76)
- A comparison of sodium-dependent glutamate binding with high-affinity glutamate uptake in rat striatum (1980) (76)
- The possible role of complement activation in Alzheimer disease. (2002) (76)
- Lipid peroxides in brain during aging and vitamin E deficiency: Possible relations to changes in neurotransmitter indices (1982) (76)
- Choline acetyltransferase: purification and immunohistochemical localization. (1984) (75)
- Retrograde HRP tracing combined with a pharmacohistochemical method for GABA transaminase for the identification of presumptive GABAergic projections to the habenula (1984) (74)
- Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons (1992) (74)
- Lamotrigine protects against kainate but not ibotenate lesions in rat striatum (1990) (74)
- Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis (2015) (72)
- Immunohistochemical localization of hyaluronic acid in rat and human brain (1994) (72)
- Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens. (1997) (71)
- Familial nature and continuing morbidity of the amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam (1997) (71)
- Cholinergic synapse of the interpeduncular nucleus (1977) (70)
- Immunohistochemical staining of the human forebrain with monoclonal antibody to human choline acetyltransferase (1983) (69)
- Possible changes in striatal and limbic cholinergic systems in schizophrenia. (1977) (69)
- Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease (1998) (68)
- A Method for Diagnosing Alzheimer's Disease Based on Salivary Amyloid-β Protein 42 Levels. (2016) (68)
- Presumptive γ-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-γ-aminobutyric acid transaminase pharmacohistochemical method (1984) (64)
- Amine synthesis in various brain regions with caudate or septal lesions. (1969) (64)
- Cholinergic enzyme systems in Parkinson's disease. (1971) (64)
- Aging and neurotransmitter systems. (1980) (64)
- Chemistry of mood and emotion. (1980) (63)
- Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrast with loss in Parkinson's disease (1994) (63)
- Brainstem projecting neurons in the rat basal forebrain: Neurochemical, topographical, and physiological distinctions from cortically projecting cholinergic neurons (1989) (63)
- Quercetin, not caffeine, is a major neuroprotective component in coffee (2016) (62)
- Kainic acid: The neurotoxic breakthrough. (1982) (61)
- Formation of adrenaline by brain tissue (1964) (60)
- Striatonigral and pallidonigral pathways studied by a combination of retrograde horseradish peroxidase tracing and a pharmacohistochemical method for γ-aminobutyric acid transaminase (1985) (60)
- Neurotransmitter systems in aging and senile dementia. (1981) (60)
- Fine structural analysis of the cortico‐striatal pathway (1979) (59)
- Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases (1994) (59)
- Complement regulators C1 inhibitor and CD59 do not significantly inhibit complement activation in Alzheimer disease (1999) (59)
- Anatomy and Pathology of the Basal Ganglia (1987) (59)
- The use of kainic acid in the localization of enzymes in the substantia nigra (1978) (59)
- GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease. (2013) (57)
- Complement proteins and complement inhibitors in Alzheimer's disease. (1992) (57)
- Effect of selective inhibitors of tyrosine and tryptophan hydroxylases on self-stimulation in the rat. (1970) (55)
- Distribution of tyrosine hydroxylase activity in adult and developing brain. (1967) (55)
- Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA (1999) (55)
- NOSH‐aspirin (NBS‐1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders (2013) (54)
- Evidence for descending pallido-nigral GABA-containing neurons. (1974) (54)
- Neurotransmitter synthetic enzymes. (1973) (53)
- A case of adult‐onset dementia with argyrophilic grains (1989) (53)
- Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease. (2002) (52)
- The effect of brain stem lesions on tyrosine and tryptophan hydroxylases in various structures of the telencephalon of the cat. (1969) (52)
- PERIPHERAL‐TYPE BENZODIAZEPINE BINDING IN ALZHEIMER DISEASE (1988) (51)
- A substance P projection to the hippocampus (1981) (51)
- Acetylcholinesterase fibers and the development of senile plaques (1987) (51)
- Autotoxicity and Alzheimer disease. (2000) (51)
- Circadian Rhythm in Pineal Tyrosine Hydroxylase (1966) (51)
- History of Innate Immunity in Neurodegenerative Disorders (2011) (50)
- Subcellular localization of tyrosine hydroxylase in beef caudate nucleus. (1965) (50)
- Dendro axonic neurotransmission. II. Morphological sites for the synthesis, binding and release of neurotransmitters in dopaminergic dendrites in the substantia nigra and cholinergic dendrites in the neostriatum (1979) (50)
- Morphology of cortically projecting basal forebrain neurons in the rat as revealed by intracellular iontophoresis of horseradish peroxidase (1987) (49)
- Effects of cannabinoids on testosterone and protein synthesis in rat testis leydig cells in vitro (1979) (49)
- Two types of dystrophic neurites in senile plaques of alzheimer disease and elderly non-demented cases (1994) (48)
- Histological and biochemical pathology in a family with autosomal dominant Parkinsonism and dementia (1993) (48)
- Occurrence of HLA‐DR Reactive Microglia in Alzheimer's Disease (1988) (47)
- LOCALIZATION OF GLUTAMINASE IN THE RAT NEOSTRIATUM (1979) (47)
- The α-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease (2008) (47)
- Substantia nigra cell death from kainic acid or folic acid injections into the pontine tegmentum (1984) (46)
- Inflammatory Cytokines in the CNS (1997) (46)
- Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates β-amyloid protein activation of complement in vitro (1997) (46)
- Alzheimer’s Disease Can Be Spared by Nonsteroidal Anti-Inflammatory Drugs (2017) (45)
- Expression of the complement membrane attack complex and its inhibitors in Pick disease brain (1994) (45)
- GABAergic and cholinergic indices in various regions of rat brain after intracerebral injections of folic acid (1983) (45)
- Physiological evidence for subpopulations of cortically projecting basal forebrain neurons in the anesthetized rat (1987) (44)
- Methylmercury-induced movement and postural disorders in developing rat: regional analysis of brain catecholamines and indoleamines (1988) (44)
- Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease (1989) (44)
- High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain (1992) (43)
- Neurotoxins as tools in neurobiology. (1981) (42)
- Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation. (2015) (42)
- Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in alzheimer's disease (1990) (42)
- Confirmatory data on habenular projections (1979) (42)
- Targeting microglia for the treatment of Alzheimer’s disease (2015) (41)
- Optineurin in Huntington's disease intranuclear inclusions (2012) (41)
- Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases (2016) (41)
- Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels (2011) (41)
- Light microscopic evidence for a substance P-containing innervation of the human nucleus basalis of Meynert (1987) (41)
- Is there a future for vaccination as a treatment for Alzheimer’s disease? (2003) (40)
- Choline acetyltransferase in developing rat brain and spinal cord (1977) (40)
- Ultrastructure of reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase-positive neurons in the cat cerebral cortex, amygdala and caudate nucleus (1988) (40)
- Enhancement of immunoreactivity for NF-kappa B in human cerebral infarctions. (1996) (39)
- Ontogeny of histidine‐decarboxylase‐immunoreactive neurons in the tuberomammillary nucleus of the rat hypothalamus: Time of origin and development of transmitter phenotype (1988) (38)
- Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome (1985) (38)
- Chemical and autoradiographic analysis of γ-aminobutyric acid transport in Purkinje cells of the cerebellum (1975) (38)
- Central aromatic amine levels and behavior. I. Conditioned avoidance response in cats, following administration of psychoactive drugs or amine precursors. (1963) (38)
- Dendro axonic transmission. I. Evidence from receptor binding of dopaminergic and cholinergic agents (1979) (38)
- Kainic acid binding to membranes of striatal neurons. (1979) (38)
- Interleukin 1α and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage (2004) (37)
- Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease (1998) (37)
- Differential effect of kainic acid on somatostatin, GABAergic and cholinergic neurons in the rat striatum (1985) (37)
- Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases (1998) (36)
- The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model. (1999) (36)
- Cortical Glutaminase, β-Glucuronidase and Glucose Utilization in Alzheimer's Disease (1989) (35)
- A review of human diseases caused or exacerbated by aberrant complement activation (2017) (35)
- EXCRETION OF 4-AMINO-5-IMIDAZOLECARBOXAMIDE IN HUMAN URINE (1961) (35)
- Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques (2002) (34)
- 6-Hydroxydopamine and striatal acetylcholine levels. (1974) (34)
- Innate immunity in Alzheimer's disease: a model for local inflammatory reactions. (2001) (34)
- Thalamic injections of kainic acid produce myocardial necrosis. (1979) (33)
- Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease (1993) (33)
- Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase-positive neurons in cat cerebral white matter (1988) (33)
- Central aromatic amines and behavior. III. Correlative analysis of conditioned approach behavior and brain levels of serotonin and catecholamines in monkeys. (1966) (32)
- Relationship of Complement-Activated Oligodendrocytes to Reactive Microglia and Neuronal Pathology in Neurodegenerative Disease (1991) (31)
- A histochemical study of GABA-transaminase in the efferents of the pallidum (1982) (31)
- Neurotoxic effects of endogenous materials: Quinolinic acid, l-pyroglutamic acid, and thyroid releasing hormone (TRH) (1984) (30)
- The distribution of somatostatin-immunoreactive neurons and fibers in the rat cerebral cortex: light and electron microscopic studies (1987) (30)
- Cortical Metabolism, Acetylcholinesterase Staining and Pathological Changes in Alzheimers Disease (1986) (30)
- Distribution and persistence of kainic acid in brain. (1979) (30)
- Decreased prostaglandin synthesis in postmortem cerebral cortex from patients with Alzheimer's disease (1992) (29)
- IN VITRO SCREEN OF INHIBITORS OF RAT BRAIN TYROSINE HYDROXYLASE (1967) (29)
- Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease. (2009) (29)
- Involvement of microglia in Alzheimer's disease. (1994) (29)
- Aromatic excretory pattern of schizophrenics. (1956) (29)
- In vitro screen of inhibitors of rat brain serotonin synthesis. (1969) (28)
- Relation of aromatic amino acids to excretory pattern of schizophrenics. (1956) (28)
- Clinically tested drugs for Alzheimer’s disease (2003) (28)
- Non-cholinergic basal forebrain neurons project to the contralateral basal forebrain in the rat (1988) (28)
- Methylmercury poisoning of the developing nervous system in the rat: decreased activity of glutamic acid decarboxylase in cerebral cortex and neostriatum. (1985) (28)
- Some Immunohistochemical Features of Argyrophilic Grain Dementia With Normal Cortical Choline Acetyltransferase Levels but Extensive Subcortical Pathology and Markedly Reduced Dopamine (1992) (28)
- GABA-transaminase in the basal ganglia: a pharmacohistochemical study (1982) (28)
- Methylmercury‐Induced Movement and Postural Disorders in Developing Rat: High‐Affinity Uptake of Choline, Glutamate, and γ‐Aminobutyric Acid in the Cerebral Cortex and Caudate‐Putamen (1989) (27)
- Glutamic-acid decarboxylase and choline acetylase in Huntington's chorea and Parkinson's disease. (1973) (27)
- Ornithine aminotransferase in Huntington's disease (1982) (27)
- CYANOCARBON CHEMISTRY—SYNTHESIS AND CHEMISTRY OF TETRACYANOETHYLENE (1957) (27)
- Electron microscopic localization of labeled norepinephrine transported in nigro-striatal neurons (1975) (27)
- Localization and Possible Functions of Presenilins in Brain (1998) (27)
- THA increases action potential duration of central histamine neurons in vitro. (1988) (27)
- Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex (2012) (27)
- Putative Excitatory Neurons: Glutamate and Aspartate (1978) (26)
- Neurotoxins released from interferon-gamma-stimulated human astrocytes (2013) (26)
- Neurotransmitters and their receptors in the basal ganglia. (1993) (26)
- Lack of support for bexarotene as a treatment for Alzheimer's disease (2016) (26)
- Autoradiographic study on dopamine uptake sites and their correlation with dopamine levels and their striata from patients with Parkinson disease, Alzheimer disease, and neurologically normal controls. (1993) (26)
- The pharmacohistochemical demonstration of GABA-transaminase (1980) (25)
- Neonatal enzymic development in the interpeduncular nucleus and surrounding ventral tegmentum (1976) (24)
- Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation (2007) (23)
- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain (2001) (23)
- Angiotensin-Converting Enzyme in Cortical Tissue in Alzheimer's and Some Other Neurological Diseases (1992) (23)
- Transplantation of Newborn Brain Tissue into Adult Kainic-Acid-Lesioned Neostriatum (1984) (23)
- Chronic taurine effects on various neurochemical indices in control and kainic acid-lesioned neostriatum (1979) (23)
- Signaling in the Nervous System (1978) (23)
- Preconditioning reduces myocardial complement gene expression in vivo. (2000) (23)
- The histochemical localization of GABA-transaminase in the efferents of the striatum (1981) (23)
- Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxam ide (PK 11195) on some mononuclear phagocyte functions. (2000) (23)
- Neuropsychological "systems efficiency" and positron emission tomography. (1989) (23)
- Conversion of tyrosine to catecholamines by cat brain in vivo (1963) (22)
- Lasting influence of amygdaloid kindling on cholinergic neurotransmission (1982) (22)
- AROMATIC METABOLISM IN SCHIZOPHRENIA II. Bidimensional Urinary Chromatograms (1957) (21)
- Inhibition of angiotensin converting enzyme by substance P (1979) (21)
- Binding of [3H]histamine to receptor sites in rat brain (1979) (21)
- Interferon-γ-induced neurotoxicity of human astrocytes. (2015) (21)
- Strain differences and kainic acid neurotoxicity (1979) (21)
- Sodium-dependent glutamate binding in senile dementia (1987) (21)
- Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2012) (20)
- Dopamine-acetylcholine-GABA neuronal linkages in the extrapyramidal and limbic systems. (1977) (20)
- The localization of GABA-transaminase in the striato-nigral system. (1980) (20)
- Inhibitory Amino Acid Neurons: GABA and Glycine (1978) (20)
- Clusterin as a marker for ischaemic Purkinje cells in human brain. (1994) (20)
- Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein. (1998) (19)
- A general chromatographic survey of aromatic compounds obtained from urine. (1959) (19)
- Cholinergic Systems and Cholinergic Pathology (1984) (19)
- Aurin Tricarboxylic Acid Protects against Red Blood Cell Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinemia (2014) (18)
- Inhibitory Amino Acid Neurotransmitters (1987) (18)
- Two immunologically different choline acetyltransferases in human neostriatum (1975) (17)
- gamma-Glutamyltransferase: normal cortical levels in Alzheimer disease. (1987) (17)
- Biochemical alterations induced by cannabinoids in the Leydig cells of the rat testis in vitro: effects on testosterone and protein synthesis. (1978) (17)
- The ultrastructure of somatostatin-immunoreactive cell bodies, nerve fibers and terminals in the dorsal horn of rat spinal cord. (1988) (17)
- Apparent anterograde transport of basic fibroblast growth factor in the rat nigrostriatal dopamine system (1992) (17)
- Inhibition of brain tyrosine hydroxylase by 5-halotryptophans. (1967) (17)
- Anti-choline acetyltransferase fragments antigen binding (Fab) for immunohistochemistry (1981) (17)
- RF VALUES OF SOME CATECHOLAMINES, PRECURSORS AND METABOLITES. (1964) (17)
- Metabolic alterations in an animal model of Huntington's disease using the 14C-deoxyglucose method. (1980) (17)
- Chromatographic characteristics of some aromatic compounds of biological interest. (1961) (16)
- Accumulation and axoplasmic transport of dopamine but not of amino acids by axons of the nigro-neostriatal projection. (1974) (16)
- Parallel distributed processing and neural networks: origins, methodology and cognitive functions. (1991) (16)
- Neurotoxic factors released by stimulated human monocytes and THP-1 cells (2011) (16)
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- Chronic inflammation in Alzheimer’s disease offers therapeutic opportunities (2001) (15)
- Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages (2013) (15)
- Metabolism of catecholamines in cold‐exposed rats 1 (1969) (15)
- Cholinergic Systems in the CNS (1982) (15)
- Ethanol, baclofen, and kainic acid neurotoxicity (1980) (15)
- Biochemical interactions in the basal ganglia. (1979) (15)
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- Biochemical Neuroanatomy of the Basal Ganglia (1989) (15)
- The L-DOPA story - an early Japanese contribution (2000) (15)
- The effect of amantadine on spontaneous locomotor activity in the rat (1971) (14)
- Transmitters in the Basal Ganglia (1978) (14)
- Midkine-like immunoreactivity in extracellular neurofibrillary tangles in brains of patients with parkinsonism-dementia complex of Guam (1996) (13)
- Abeta immunotherapy and other means to remove amyloid. (2005) (13)
- Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia (2004) (13)
- Mapping of Cholinergic Systems in Rostral Forebrain of the Rodent (1981) (13)
- Physiological effects of schizophrenic body fluids. (1959) (13)
- Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate (1989) (13)
- A clinical trial of folic acid in Parkinson's disease. (1972) (12)
- Cholinergic systems in extrapyramidal function. (1976) (12)
- Comparative enzymatic development in chick embryonic brain areas. (1974) (12)
- Presumptive gamma-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-gamma-aminobutyric acid transaminase pharmacohistochemical method. (1984) (12)
- Some factors influencing the neurotoxicity of intrastriatal injections of kainic acid (1978) (12)
- Aromatic metabolism in schizophrenia. I. Statistical evidence for aromaturia. (1957) (12)
- Research report Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease (2000) (11)
- The susceptibility to audiogenic stimuli of rats treated with methionine sulfoximine and various psychoactive agents. (1967) (11)
- Cytomegalovirus infection of the developing brain alters catecholamine and indoleamine metabolism (1991) (11)
- Serotonin and Other Brain Indoles (1987) (10)
- Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease (1994) (10)
- Increased acoplasmic transport of H3-dopamine in nigro-neostriatal neurons after reserpine. (1973) (10)
- GABA-transaminase and glutamic acid decarboxylase changes in the brain of rats treated with pyrithiamine (1985) (10)
- Expression of HLA-DR and interleukin-2 receptor on reactive microglia in senile dementia of the alzheimer's type (1987) (10)
- Coupled intracellular horseradish peroxidase-monoamine oxidase histochemistry: description of the technique and its application to the study of physiologically identified tuberomammillary neurons (1987) (9)
- CONVERSION OF TYROSINE TO CATECHOLAMINES BY RAT BRAIN SLICES (1963) (9)
- Effect of amethopterin and vincaleukoblastinc on urinary 4-amino-5-imidazolecarboxamide☆ (1963) (9)
- P3.191 LRRK2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications (2009) (9)
- TRYPTOPHAN HYDROXYLASE INHIBITORS OTHER THAN PCPA (1973) (9)
- Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease (1986) (9)
- IMMUNE MECHANISMS IN NEURODEGENERATIVE DISORDERS (1996) (9)
- Aging, Neurodegenerative Disease and the Brain (1997) (8)
- Tetrahydroaminoacridine potentiates neurotoxicity of quinolinic acid in rat striatum (1988) (8)
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- Strategies for the Identification of Novel Brain Specific Genes Affected in Alzheimer Disease (1989) (8)
- Growth Factors in Parkinson’s Disease (1994) (8)
- Immunohistochemistry of choline acetyltransferase. (1979) (8)
- HLA-DR reactive microglia in Parkinson's disease (1987) (7)
- Inflammatory Processes Exacerbate Degenerative Neurological Disorders (2009) (7)
- Changes of [3H]colchicine binding and protein synthesis in the rat striatum following kainic acid lesions (1978) (7)
- Saliva Diagnosis as a Disease Predictor (2020) (7)
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- Possible cortico-hypothalamic glycinergic tract (1980) (7)
- Monoamines and their metabolites in Huntington's disease brain: Evidence for decreased catechol-O-methyltransferase activity (1993) (7)
- Control of Movement by the Brain (1978) (7)
- Protein and RNA synthesis in kainic acid-injected striata (1979) (7)
- Increased Uric Acid in the Developing Brain and Spinal Cord Following Cytomegalovirus Infection (1989) (7)
- CHAPTER 2 – Amino Acid Hydroxylase Inhibitors (1973) (6)
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- Distribution of Cholinergic Neurons in Human Brain (1987) (6)
- Changes in striatal neuron-specific enolase (NSE) and non-neuronal enolase (NNE) following kainic acid administration (1980) (6)
- Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid (2015) (6)
- Effect of fixatives on rat brain acetylcholinesterase activity (1989) (6)
- Preliminary Survey of 4-Amino-5-Imidazolecarboxamide Excretion in Leukemia and Other Illnesses. (1961) (6)
- Biochemical Mapping of Specific Neuronal Pathways (1980) (6)
- Cysteinesulfinate decarboxylase activity as an index of taurine‐containing structures (1980) (6)
- Excitatory amino acids and Alzheimer's disease: Idle thoughts on an exciting subject (1989) (5)
- Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS (1986) (5)
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- Immunotherapy for Alzheimer's disease. (2004) (4)
- GABA Enzymes and Pathways (1982) (4)
- Cross-reactivity of antibodies to chicken brain choline acetyltransferase with mammalian enzyme (1982) (4)
- Evidence for descending basal forebrain projections anatomical and physiological studies (1986) (4)
- Neuronal Mechanisms Involved in Learning and Memory (1978) (4)
- Comparative inhibition of biosynthetic processes in rat liver testicular cells by D-, L,-and DL-methadone. (1978) (4)
- Central nervous system immune reactions in Alzheimer's disease (1997) (4)
- Integration of Motor Functions in the Basal Ganglia (1987) (4)
- Cardiovascular events and COX-2 inhibitors. (2001) (4)
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- Vitamin B6 in mental deficiency: xanthurenic acid excretion in phenylketonurics. (1958) (4)
- Excitotoxic amino acids as tools in neurobiology. (1983) (3)
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- GABA accumulation by embryonic chick tectum. (1975) (3)
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- Prospects for preventing alzheimer's disease (1999) (3)
- Effects of folic acid on the phenylalanine tolerance test in phenylketonuria. (1962) (3)
- The Prominent Peptides (1987) (3)
- Morphine, naloxone and kainic acid neurotoxicity. (1979) (2)
- Synaptic morphology in the neostriatum of the rat: Possible serotonergic synapse (1976) (2)
- A possible relationship between folic acid neurotoxicity and cholinergic receptors in the pyriform cortex and amygdala. (1983) (2)
- The Future Use of Complement Inhibitors for the Treatment of Neurological Diseases (1998) (2)
- Intracerebral injections of kainic acid and tetanus toxin: possible models for the signs of chorea and dystonia. (1978) (2)
- Vitamin B6 and mental deficiency; the effects of large doses of B6 (pyridoxine) in phenylketonuria. (1959) (2)
- Cardiovascular events and COX-2 inhibitors. Authors' reply (2001) (2)
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- Principles of Synaptic Biochemistry (1987) (2)
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- Innate Inflammatory Reaction of the Brain in Alzheimer Disease (2020) (2)
- METABOLISM OF CATECHOLAMINES, GABA AND ACETYLCHOLINE (1975) (2)
- Other Heterocyclic Putative Neurotransmitters: Histamine and Purines (1987) (1)
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- Toxicity of p-methoxyphenol to dopamine neurons in the rat substantia nigra (1987) (1)
- Complement, neuroinflammation and neuronal degeneration in Alzheimer disease (2001) (1)
- γ-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate (1990) (1)
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- Effect of Cannabinoids and Narcotics on Gonadal Functions (1981) (1)
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- ???THE ROLE OF THE NUCLEUS BASALIS OF MEYNERT IN DEMENTIA: REVIEW AND RECONSIDERATION??? (1987) (0)
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- Neuroimmune Mechanisms In The Pathogenesis Of Alzheimer’s Disease (2019) (0)
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- 807 Evidence supporting the inflammatory hypothesis of Alzheimer disease (1996) (0)
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- Distribution and metabolism of apolipoproteins in the brains with aging and alzheimer-type dementia alzheimer's disease (1994) (0)
- The Fine Structure of the Mammalian Brain (1978) (0)
- Neuroinflammation, Alzheimer Disease, and Other Aging Disorders (2007) (0)
- Inflammation and the lesions of Alzheimer’s disease (2006) (0)
- The Building of the Brain and Its Adaptive Capacity (1978) (0)
- Putative Transmitters and Transmitter Candidates (1978) (0)
- Novel neuroprotective hydrogen sulfide-releasing L-DOPA derivatives for the treatment of Parkinson disease (2010) (0)
- Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2011) (0)
- Erratum to: Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2012) (0)
- Immune System Reaction to Model Lesions of Rat Brain (1990) (0)
- CORTICALLY PROJECTING BASAL FOREBRAIN NEURONS IN THE ANESTHETIZED RAT OF (2002) (0)
- Positron emission tomography and histopathology in Pickʼs disease (1987) (0)
- Milk Fat Globule Epidermal Growth Factor 8 ( MFG-E 8 ) Expression in Progressive Supranuclear Palsy (2016) (0)
- Excretion of 4-Amino-5-Imidazolecarboxamide by Mental Patients (1963) (0)
- Effects of d1-methadone and morphine on developing chick embryo (1978) (0)
- Functional Roles of Group II Metabotropic Glutamate Receptors in the Hippocampal CA1 Network (2015) (0)
- Aurin tricarboxylic acid may help Alzheimer's disease and other conditions by blocking the MAC of complement (2012) (0)
- Immunohistochemical Features which Distinguish Pallido‐Nigro‐Luysial Atrophy from Progressive Supranuclear Palsy (1994) (0)
- Iontophoresis of kainic acid (2004) (0)
- 3-12-06 Glial cell reactions in dementia: Pathophysiology and therapeutic interventions (1997) (0)
- Aging and neurotransmitter systems. (1978) (0)
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