Edith Graef Mcgeer

Edith Graef Mcgeer's AcademicInfluence.com Rankings

Edith Graef Mcgeer

Biology

#2918

World Rank

#4548

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Neuroscience

#257

World Rank

#271

Historical Rank

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Biology

Edith Graef Mcgeer's Degrees

PhD Neuroscience University of British Columbia
Bachelors Biology University of British Columbia

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Edith Graef Mcgeer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains (1988) (2578)
Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease (1996) (1396)
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases (1995) (1326)
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat (1981) (857)
Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids (1976) (828)
Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR (1987) (817)
Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry (1983) (690)
Kainic acid as a tool in neurobiology (1978) (682)
Glial reactions in Parkinson's disease (2008) (664)
Aging and extrapyramidal function. (1977) (662)
Generation of C-reactive protein and complement components in atherosclerotic plaques. (2001) (625)
Microglia in degenerative neurological disease (1993) (603)
Inflammation and neurodegeneration in Parkinson's disease. (2004) (593)
Rate of cell death in parkinsonism indicates active neuropathological process (1988) (560)
Inflammation and the Degenerative Diseases of Aging (2004) (520)
Molecular Neurobiology of the Mammalian Brain (1978) (496)
Inflammation, autotoxicity and Alzheimer disease (2001) (492)
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies (2007) (491)
Aging, Alzheimer's disease, and the cholinergic system of the basal forebrain (1984) (478)
ENZYMES ASSOCIATED WITH THE METABOLISM OF CATECHOLAMINES, ACETYLCHOLINE AND GABA IN HUMAN CONTROLS AND PATIENTS WITH PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA (1976) (477)
A glutamatergic corticostriatal path? (1977) (474)
Inflammatory processes in amyotrophic lateral sclerosis (2002) (472)
Immune System Response in Alzheimer's Disease (1989) (468)
Anti-inflammatory drugs and Alzheimer disease (1990) (438)
Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K (1990) (415)
Activation of the classical complement pathway in brain tissue of Alzheimer patients (1989) (395)
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy (2013) (356)
Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide (2001) (350)
The importance of inflammatory mechanisms in alzheimer disease (1998) (339)
Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. (1980) (336)
Up-regulated production and activation of the complement system in Alzheimer's disease brain. (1999) (333)
Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract (1978) (324)
Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. (2010) (322)
Inflammation in Parkinson's disease. (2001) (306)
Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer’s disease (2000) (300)
Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome. (1973) (292)
On the source of GABA-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies. (1973) (288)
Distribution of reduced‐nicotinamide‐adenine‐dinucleotide‐phosphate diaphorase‐positive cells and fibers in the cat central nervous system (1989) (287)
Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat (1988) (283)
Neostriatal choline acetylase and cholinesterase following selective brain lesions. (1971) (274)
Inflammatory processes in Alzheimer's disease (2003) (273)
Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs (1999) (249)
Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. (2006) (242)
Inflammation of the brain in Alzheimer's disease: implications for therapy (1999) (233)
Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain (2001) (217)
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia (2008) (213)
Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls (1983) (208)
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases (2010) (207)
Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys (2006) (207)
Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain (1997) (203)
Therapeutic approaches to inflammation in neurodegenerative disease (2007) (200)
Aging and brain enzymes. (1971) (198)
Polymorphisms in inflammatory genes and the risk of Alzheimer disease. (2001) (196)
Brain inflammation in Alzheimer disease and the therapeutic implications. (1999) (194)
Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue (1992) (191)
The nigrotectal projection: a biochemical and ultrastructural characterization (1978) (190)
Inflammation, the complement system and the diseases of aging (2005) (187)
Choline acetylase and glutamic acid decarboxylase in Huntington's chorea (1973) (187)
Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide (2009) (185)
Evidence for glutamic acid decarboxylase-containing interneurons in the neostriatum (1975) (178)
LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines (2006) (173)
Immunohistochemical localization of choline acetyltransferase containing neostriatal neurons and their relationship with dopaminergic synapses (1976) (164)
Influence of noncholinergic drugs on rat striatal acetylcholine levels. (1974) (159)
Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration. (1973) (158)
Marked increase in cyclooxygenase-2 in ALS spinal cord (2001) (158)
Human heart generates complement proteins that are upregulated and activated after myocardial infarction. (1998) (156)
Neuroimmune Mechanisms in Alzheimer Disease Pathogenesis (1994) (155)
Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years. (2016) (151)
Cholinergic projections from the basal forebrain of rat to the amygdala (1982) (146)
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. (2009) (145)
Neurons express proteins of the classical complement pathway in Alzheimer disease (1997) (144)
Fine structural changes in the rat striatum after local injections of kainic acid (1977) (142)
Distribution of choline acetyltransferase immunopositive structures in the rat brainstem (1989) (139)
Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase. (1971) (138)
Some characteristics of brain tyrosine hydroxylase. (1967) (138)
Positron emission tomography and histopathology in Pick's disease (1987) (137)
Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease (1986) (134)
Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease (1994) (133)
Choline acetyltransferase localization in the central nervous system by immunohistochemistry. (1974) (128)
Alzheimer disease and neuroinflammation. (2000) (122)
Early response of brain resident microglia to kainic acid-induced hippocampal lesions (1994) (118)
Anti‐Inflammatory Drugs in the Fight against Alzheimer's Disease a (1996) (117)
AXONAL TRANSPORT IN NIGRO‐STRIATAL AND NIGRO‐THALAMIC NEURONS: EFFECTS OF MEDIAL FOREBRAIN BUNDLE LESIONS AND 6‐HYDROXYDOPAMINE 1 (1972) (117)
Positron emission tomography in patients with clinically diagnosed Alzheimer's disease. (1986) (116)
Myelin degeneration in multiple system atrophy detected by unique antibodies. (1998) (115)
Complement Components, but Not Complement Inhibitors, Are Upregulated in Atherosclerotic Plaques (2001) (110)
Mechanisms of GABA release from human astrocytes (2011) (110)
Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain (2000) (108)
Expression of MRP14, 27E10, interferon-α and leukocyte common antigen by reactive microglia in postmortem human brain tissue (1994) (106)
Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease (2002) (106)
Prevalence of Dementia amongst Elderly Japanese with Leprosy: Apparent Effect of Chronic Drug Therapy (1992) (105)
Lipid Peroxide Distribution in Brain and the Effect of Hyperbaric Oxygen (1983) (104)
Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain (1991) (104)
The role of the immune system in neurodegenerative disorders (1997) (102)
Cyanocarbon Chemistry. I. Preparation and Reactions of Tetracyanoethylene (1958) (97)
THE INHIBITORY ACTION OF 3‐HYDROXYTYRAMINE, GAMMA‐AMINOBUTYRIC ACID (GABA) AND SOME OTHER COMPOUNDS TOWARDS THE CRAYFISH STRETCH RECEPTOR NEURON * (1961) (97)
Differential development of caudate enzymes in the neonatal rat. (1971) (96)
Peroxidase-labeled lectin as a neuroanatomical tracer: evaluation in a CNS pathway (1980) (95)
The Role of Anti-Inflammatory Agents in Parkinson’s Disease (2007) (95)
Hydrogen sulfide‐releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation (2010) (95)
THE DISTRIBUTION OF TRYPTOPHAN HYDROXYLASE IN CAT BRAIN (1968) (94)
Innate immunity, local inflammation, and degenerative disease. (2002) (92)
Reactions of the Immune System in Chronic Degenerative Neurological Diseases (1991) (92)
High stability of mRNAs postmortem and protocols for their assessment by RT-PCR. (2001) (92)
Age Changes in the Human for Some Enzymes Associated with Metabolism of Catecholamines, GABA and Acetylcholine (1975) (91)
Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage (1992) (91)
Neurotransmitters in the Basal Ganglia (1984) (90)
Evidence on the cellular localization of adenyl cyclase in the neostriatum (1976) (90)
Central Aromatic Amine Levels and Behavior: II. Serotonin and Catecholamine Levels in Various Cat Brain Areas Following Administration of Psychoactive Drugs or Amine Precursors (1963) (89)
Inhibition of rat brain tryptophan hydroxylase by 6-halotryptophans. (1968) (88)
Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease (1995) (87)
Pathological proteins in senile plaques. (1994) (86)
Synaptic Transmission in the Central Nervous System (1978) (83)
18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans (1990) (82)
The pentraxins: possible role in Alzheimer’s disease and other innate inflammatory diseases (2001) (82)
Postnatal changes of GABAergic and glutamatergic parameters. (1981) (81)
Mechanisms of cell death in Alzheimer disease--immunopathology. (1998) (81)
Distribution of glutamic acid decarboxylase in the brains of various mammalian species. (1970) (81)
Glutamic acid decarboxylase in Parkinson's disease and epilepsy (1971) (79)
Effects of Hydrogen Sulfide-releasing l-DOPA Derivatives on Glial Activation (2010) (79)
Enhancement of immunoreactivity for NF-κB in human cerebral infarctions (1996) (79)
6‐[18F]fluoro‐L‐DOPA PET studies of the turnover of dopamine in MPTP‐induced parkinsonism in monkeys (1998) (78)
Electrophysiological properties of cortically projecting histamine neurons of the rat hypothalamus (1987) (77)
Transmitters contained in the efferents of the habenula (1980) (76)
A comparison of sodium-dependent glutamate binding with high-affinity glutamate uptake in rat striatum (1980) (76)
The possible role of complement activation in Alzheimer disease. (2002) (76)
Lipid peroxides in brain during aging and vitamin E deficiency: Possible relations to changes in neurotransmitter indices (1982) (76)
Choline acetyltransferase: purification and immunohistochemical localization. (1984) (75)
Retrograde HRP tracing combined with a pharmacohistochemical method for GABA transaminase for the identification of presumptive GABAergic projections to the habenula (1984) (74)
Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons (1992) (74)
Lamotrigine protects against kainate but not ibotenate lesions in rat striatum (1990) (74)
Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis (2015) (72)
Immunohistochemical localization of hyaluronic acid in rat and human brain (1994) (72)
Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens. (1997) (71)
Familial nature and continuing morbidity of the amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam (1997) (71)
Cholinergic synapse of the interpeduncular nucleus (1977) (70)
Immunohistochemical staining of the human forebrain with monoclonal antibody to human choline acetyltransferase (1983) (69)
Possible changes in striatal and limbic cholinergic systems in schizophrenia. (1977) (69)
Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease (1998) (68)
A Method for Diagnosing Alzheimer's Disease Based on Salivary Amyloid-β Protein 42 Levels. (2016) (68)
Presumptive γ-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-γ-aminobutyric acid transaminase pharmacohistochemical method (1984) (64)
Amine synthesis in various brain regions with caudate or septal lesions. (1969) (64)
Cholinergic enzyme systems in Parkinson's disease. (1971) (64)
Aging and neurotransmitter systems. (1980) (64)
Chemistry of mood and emotion. (1980) (63)
Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrast with loss in Parkinson's disease (1994) (63)
Brainstem projecting neurons in the rat basal forebrain: Neurochemical, topographical, and physiological distinctions from cortically projecting cholinergic neurons (1989) (63)
Quercetin, not caffeine, is a major neuroprotective component in coffee (2016) (62)
Kainic acid: The neurotoxic breakthrough. (1982) (61)
Formation of adrenaline by brain tissue (1964) (60)
Striatonigral and pallidonigral pathways studied by a combination of retrograde horseradish peroxidase tracing and a pharmacohistochemical method for γ-aminobutyric acid transaminase (1985) (60)
Neurotransmitter systems in aging and senile dementia. (1981) (60)
Fine structural analysis of the cortico‐striatal pathway (1979) (59)
Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases (1994) (59)
Complement regulators C1 inhibitor and CD59 do not significantly inhibit complement activation in Alzheimer disease (1999) (59)
Anatomy and Pathology of the Basal Ganglia (1987) (59)
The use of kainic acid in the localization of enzymes in the substantia nigra (1978) (59)
GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease. (2013) (57)
Complement proteins and complement inhibitors in Alzheimer's disease. (1992) (57)
Effect of selective inhibitors of tyrosine and tryptophan hydroxylases on self-stimulation in the rat. (1970) (55)
Distribution of tyrosine hydroxylase activity in adult and developing brain. (1967) (55)
Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA (1999) (55)
NOSH‐aspirin (NBS‐1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders (2013) (54)
Evidence for descending pallido-nigral GABA-containing neurons. (1974) (54)
Neurotransmitter synthetic enzymes. (1973) (53)
A case of adult‐onset dementia with argyrophilic grains (1989) (53)
Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease. (2002) (52)
The effect of brain stem lesions on tyrosine and tryptophan hydroxylases in various structures of the telencephalon of the cat. (1969) (52)
PERIPHERAL‐TYPE BENZODIAZEPINE BINDING IN ALZHEIMER DISEASE (1988) (51)
A substance P projection to the hippocampus (1981) (51)
Acetylcholinesterase fibers and the development of senile plaques (1987) (51)
Autotoxicity and Alzheimer disease. (2000) (51)
Circadian Rhythm in Pineal Tyrosine Hydroxylase (1966) (51)
History of Innate Immunity in Neurodegenerative Disorders (2011) (50)
Subcellular localization of tyrosine hydroxylase in beef caudate nucleus. (1965) (50)
Dendro axonic neurotransmission. II. Morphological sites for the synthesis, binding and release of neurotransmitters in dopaminergic dendrites in the substantia nigra and cholinergic dendrites in the neostriatum (1979) (50)
Morphology of cortically projecting basal forebrain neurons in the rat as revealed by intracellular iontophoresis of horseradish peroxidase (1987) (49)
Effects of cannabinoids on testosterone and protein synthesis in rat testis leydig cells in vitro (1979) (49)
Two types of dystrophic neurites in senile plaques of alzheimer disease and elderly non-demented cases (1994) (48)
Histological and biochemical pathology in a family with autosomal dominant Parkinsonism and dementia (1993) (48)
Occurrence of HLA‐DR Reactive Microglia in Alzheimer's Disease (1988) (47)
LOCALIZATION OF GLUTAMINASE IN THE RAT NEOSTRIATUM (1979) (47)
The α-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease (2008) (47)
Substantia nigra cell death from kainic acid or folic acid injections into the pontine tegmentum (1984) (46)
Inflammatory Cytokines in the CNS (1997) (46)
Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates β-amyloid protein activation of complement in vitro (1997) (46)
Alzheimer’s Disease Can Be Spared by Nonsteroidal Anti-Inflammatory Drugs (2017) (45)
Expression of the complement membrane attack complex and its inhibitors in Pick disease brain (1994) (45)
GABAergic and cholinergic indices in various regions of rat brain after intracerebral injections of folic acid (1983) (45)
Physiological evidence for subpopulations of cortically projecting basal forebrain neurons in the anesthetized rat (1987) (44)
Methylmercury-induced movement and postural disorders in developing rat: regional analysis of brain catecholamines and indoleamines (1988) (44)
Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease (1989) (44)
High molecular weight basic fibroblast growth factor-like protein is localized to a subpopulation of mesencephalic dopaminergic neurons in the rat brain (1992) (43)
Neurotoxins as tools in neurobiology. (1981) (42)
Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation. (2015) (42)
Correlations of regional postmortem enzyme activities with premortem local glucose metabolic rates in alzheimer's disease (1990) (42)
Confirmatory data on habenular projections (1979) (42)
Targeting microglia for the treatment of Alzheimer’s disease (2015) (41)
Optineurin in Huntington's disease intranuclear inclusions (2012) (41)
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases (2016) (41)
Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels (2011) (41)
Light microscopic evidence for a substance P-containing innervation of the human nucleus basalis of Meynert (1987) (41)
Is there a future for vaccination as a treatment for Alzheimer’s disease? (2003) (40)
Choline acetyltransferase in developing rat brain and spinal cord (1977) (40)
Ultrastructure of reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase-positive neurons in the cat cerebral cortex, amygdala and caudate nucleus (1988) (40)
Enhancement of immunoreactivity for NF-kappa B in human cerebral infarctions. (1996) (39)
Ontogeny of histidine‐decarboxylase‐immunoreactive neurons in the tuberomammillary nucleus of the rat hypothalamus: Time of origin and development of transmitter phenotype (1988) (38)
Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome (1985) (38)
Chemical and autoradiographic analysis of γ-aminobutyric acid transport in Purkinje cells of the cerebellum (1975) (38)
Central aromatic amine levels and behavior. I. Conditioned avoidance response in cats, following administration of psychoactive drugs or amine precursors. (1963) (38)
Dendro axonic transmission. I. Evidence from receptor binding of dopaminergic and cholinergic agents (1979) (38)
Kainic acid binding to membranes of striatal neurons. (1979) (38)
Interleukin 1α and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage (2004) (37)
Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease (1998) (37)
Differential effect of kainic acid on somatostatin, GABAergic and cholinergic neurons in the rat striatum (1985) (37)
Immunohistochemical analyses of fibroblast growth factor receptor-1 in the human substantia nigra. Comparison between normal and Parkinson's disease cases (1998) (36)
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model. (1999) (36)
Cortical Glutaminase, β-Glucuronidase and Glucose Utilization in Alzheimer's Disease (1989) (35)
A review of human diseases caused or exacerbated by aberrant complement activation (2017) (35)
EXCRETION OF 4-AMINO-5-IMIDAZOLECARBOXAMIDE IN HUMAN URINE (1961) (35)
Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques (2002) (34)
6-Hydroxydopamine and striatal acetylcholine levels. (1974) (34)
Innate immunity in Alzheimer's disease: a model for local inflammatory reactions. (2001) (34)
Thalamic injections of kainic acid produce myocardial necrosis. (1979) (33)
Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease (1993) (33)
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase-positive neurons in cat cerebral white matter (1988) (33)
Central aromatic amines and behavior. III. Correlative analysis of conditioned approach behavior and brain levels of serotonin and catecholamines in monkeys. (1966) (32)
Relationship of Complement-Activated Oligodendrocytes to Reactive Microglia and Neuronal Pathology in Neurodegenerative Disease (1991) (31)
A histochemical study of GABA-transaminase in the efferents of the pallidum (1982) (31)
Neurotoxic effects of endogenous materials: Quinolinic acid, l-pyroglutamic acid, and thyroid releasing hormone (TRH) (1984) (30)
The distribution of somatostatin-immunoreactive neurons and fibers in the rat cerebral cortex: light and electron microscopic studies (1987) (30)
Cortical Metabolism, Acetylcholinesterase Staining and Pathological Changes in Alzheimers Disease (1986) (30)
Distribution and persistence of kainic acid in brain. (1979) (30)
Decreased prostaglandin synthesis in postmortem cerebral cortex from patients with Alzheimer's disease (1992) (29)
IN VITRO SCREEN OF INHIBITORS OF RAT BRAIN TYROSINE HYDROXYLASE (1967) (29)
Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease. (2009) (29)
Involvement of microglia in Alzheimer's disease. (1994) (29)
Aromatic excretory pattern of schizophrenics. (1956) (29)
In vitro screen of inhibitors of rat brain serotonin synthesis. (1969) (28)
Relation of aromatic amino acids to excretory pattern of schizophrenics. (1956) (28)
Clinically tested drugs for Alzheimer’s disease (2003) (28)
Non-cholinergic basal forebrain neurons project to the contralateral basal forebrain in the rat (1988) (28)
Methylmercury poisoning of the developing nervous system in the rat: decreased activity of glutamic acid decarboxylase in cerebral cortex and neostriatum. (1985) (28)
Some Immunohistochemical Features of Argyrophilic Grain Dementia With Normal Cortical Choline Acetyltransferase Levels but Extensive Subcortical Pathology and Markedly Reduced Dopamine (1992) (28)
GABA-transaminase in the basal ganglia: a pharmacohistochemical study (1982) (28)
Methylmercury‐Induced Movement and Postural Disorders in Developing Rat: High‐Affinity Uptake of Choline, Glutamate, and γ‐Aminobutyric Acid in the Cerebral Cortex and Caudate‐Putamen (1989) (27)
Glutamic-acid decarboxylase and choline acetylase in Huntington's chorea and Parkinson's disease. (1973) (27)
Ornithine aminotransferase in Huntington's disease (1982) (27)
CYANOCARBON CHEMISTRY—SYNTHESIS AND CHEMISTRY OF TETRACYANOETHYLENE (1957) (27)
Electron microscopic localization of labeled norepinephrine transported in nigro-striatal neurons (1975) (27)
Localization and Possible Functions of Presenilins in Brain (1998) (27)
THA increases action potential duration of central histamine neurons in vitro. (1988) (27)
Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex (2012) (27)
Putative Excitatory Neurons: Glutamate and Aspartate (1978) (26)
Neurotoxins released from interferon-gamma-stimulated human astrocytes (2013) (26)
Neurotransmitters and their receptors in the basal ganglia. (1993) (26)
Lack of support for bexarotene as a treatment for Alzheimer's disease (2016) (26)
Autoradiographic study on dopamine uptake sites and their correlation with dopamine levels and their striata from patients with Parkinson disease, Alzheimer disease, and neurologically normal controls. (1993) (26)
The pharmacohistochemical demonstration of GABA-transaminase (1980) (25)
Neonatal enzymic development in the interpeduncular nucleus and surrounding ventral tegmentum (1976) (24)
Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation (2007) (23)
3-Hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain (2001) (23)
Angiotensin-Converting Enzyme in Cortical Tissue in Alzheimer's and Some Other Neurological Diseases (1992) (23)
Transplantation of Newborn Brain Tissue into Adult Kainic-Acid-Lesioned Neostriatum (1984) (23)
Chronic taurine effects on various neurochemical indices in control and kainic acid-lesioned neostriatum (1979) (23)
Signaling in the Nervous System (1978) (23)
Preconditioning reduces myocardial complement gene expression in vivo. (2000) (23)
The histochemical localization of GABA-transaminase in the efferents of the striatum (1981) (23)
Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxam ide (PK 11195) on some mononuclear phagocyte functions. (2000) (23)
Neuropsychological "systems efficiency" and positron emission tomography. (1989) (23)
Conversion of tyrosine to catecholamines by cat brain in vivo (1963) (22)
Lasting influence of amygdaloid kindling on cholinergic neurotransmission (1982) (22)
AROMATIC METABOLISM IN SCHIZOPHRENIA II. Bidimensional Urinary Chromatograms (1957) (21)
Inhibition of angiotensin converting enzyme by substance P (1979) (21)
Binding of [3H]histamine to receptor sites in rat brain (1979) (21)
Interferon-γ-induced neurotoxicity of human astrocytes. (2015) (21)
Strain differences and kainic acid neurotoxicity (1979) (21)
Sodium-dependent glutamate binding in senile dementia (1987) (21)
Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2012) (20)
Dopamine-acetylcholine-GABA neuronal linkages in the extrapyramidal and limbic systems. (1977) (20)
The localization of GABA-transaminase in the striato-nigral system. (1980) (20)
Inhibitory Amino Acid Neurons: GABA and Glycine (1978) (20)
Clusterin as a marker for ischaemic Purkinje cells in human brain. (1994) (20)
Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein. (1998) (19)
A general chromatographic survey of aromatic compounds obtained from urine. (1959) (19)
Cholinergic Systems and Cholinergic Pathology (1984) (19)
Aurin Tricarboxylic Acid Protects against Red Blood Cell Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinemia (2014) (18)
Inhibitory Amino Acid Neurotransmitters (1987) (18)
Two immunologically different choline acetyltransferases in human neostriatum (1975) (17)
gamma-Glutamyltransferase: normal cortical levels in Alzheimer disease. (1987) (17)
Biochemical alterations induced by cannabinoids in the Leydig cells of the rat testis in vitro: effects on testosterone and protein synthesis. (1978) (17)
The ultrastructure of somatostatin-immunoreactive cell bodies, nerve fibers and terminals in the dorsal horn of rat spinal cord. (1988) (17)
Apparent anterograde transport of basic fibroblast growth factor in the rat nigrostriatal dopamine system (1992) (17)
Inhibition of brain tyrosine hydroxylase by 5-halotryptophans. (1967) (17)
Anti-choline acetyltransferase fragments antigen binding (Fab) for immunohistochemistry (1981) (17)
RF VALUES OF SOME CATECHOLAMINES, PRECURSORS AND METABOLITES. (1964) (17)
Metabolic alterations in an animal model of Huntington's disease using the 14C-deoxyglucose method. (1980) (17)
Chromatographic characteristics of some aromatic compounds of biological interest. (1961) (16)
Accumulation and axoplasmic transport of dopamine but not of amino acids by axons of the nigro-neostriatal projection. (1974) (16)
Parallel distributed processing and neural networks: origins, methodology and cognitive functions. (1991) (16)
Neurotoxic factors released by stimulated human monocytes and THP-1 cells (2011) (16)
Neurotransmitters in Normal Aging (1982) (16)
Evidence for an intracerebellar acetylcholinesterase-rich but probably non-cholinergic flocculo-nodular projection in the rat (1983) (15)
Chronic inflammation in Alzheimer’s disease offers therapeutic opportunities (2001) (15)
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages (2013) (15)
Metabolism of catecholamines in cold‐exposed rats 1 (1969) (15)
Cholinergic Systems in the CNS (1982) (15)
Ethanol, baclofen, and kainic acid neurotoxicity (1980) (15)
Biochemical interactions in the basal ganglia. (1979) (15)
Rotatory effects of intracerebral tetanus toxin injections (1980) (15)
Biochemical Neuroanatomy of the Basal Ganglia (1989) (15)
The L-DOPA story - an early Japanese contribution (2000) (15)
The effect of amantadine on spontaneous locomotor activity in the rat (1971) (14)
Transmitters in the Basal Ganglia (1978) (14)
Midkine-like immunoreactivity in extracellular neurofibrillary tangles in brains of patients with parkinsonism-dementia complex of Guam (1996) (13)
Abeta immunotherapy and other means to remove amyloid. (2005) (13)
Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia (2004) (13)
Mapping of Cholinergic Systems in Rostral Forebrain of the Rodent (1981) (13)
Physiological effects of schizophrenic body fluids. (1959) (13)
Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate (1989) (13)
A clinical trial of folic acid in Parkinson's disease. (1972) (12)
Cholinergic systems in extrapyramidal function. (1976) (12)
Comparative enzymatic development in chick embryonic brain areas. (1974) (12)
Presumptive gamma-aminobutyric acid pathways from the midbrain to the superior colliculus studied by a combined horseradish peroxidase-gamma-aminobutyric acid transaminase pharmacohistochemical method. (1984) (12)
Some factors influencing the neurotoxicity of intrastriatal injections of kainic acid (1978) (12)
Aromatic metabolism in schizophrenia. I. Statistical evidence for aromaturia. (1957) (12)
Research report Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease (2000) (11)
The susceptibility to audiogenic stimuli of rats treated with methionine sulfoximine and various psychoactive agents. (1967) (11)
Cytomegalovirus infection of the developing brain alters catecholamine and indoleamine metabolism (1991) (11)
Serotonin and Other Brain Indoles (1987) (10)
Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease (1994) (10)
Increased acoplasmic transport of H3-dopamine in nigro-neostriatal neurons after reserpine. (1973) (10)
GABA-transaminase and glutamic acid decarboxylase changes in the brain of rats treated with pyrithiamine (1985) (10)
Expression of HLA-DR and interleukin-2 receptor on reactive microglia in senile dementia of the alzheimer's type (1987) (10)
Coupled intracellular horseradish peroxidase-monoamine oxidase histochemistry: description of the technique and its application to the study of physiologically identified tuberomammillary neurons (1987) (9)
CONVERSION OF TYROSINE TO CATECHOLAMINES BY RAT BRAIN SLICES (1963) (9)
Effect of amethopterin and vincaleukoblastinc on urinary 4-amino-5-imidazolecarboxamide☆ (1963) (9)
P3.191 LRRK2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications (2009) (9)
TRYPTOPHAN HYDROXYLASE INHIBITORS OTHER THAN PCPA (1973) (9)
Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease (1986) (9)
IMMUNE MECHANISMS IN NEURODEGENERATIVE DISORDERS (1996) (9)
Aging, Neurodegenerative Disease and the Brain (1997) (8)
Tetrahydroaminoacridine potentiates neurotoxicity of quinolinic acid in rat striatum (1988) (8)
Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts. (1986) (8)
Strategies for the Identification of Novel Brain Specific Genes Affected in Alzheimer Disease (1989) (8)
Growth Factors in Parkinson’s Disease (1994) (8)
Immunohistochemistry of choline acetyltransferase. (1979) (8)
HLA-DR reactive microglia in Parkinson's disease (1987) (7)
Inflammatory Processes Exacerbate Degenerative Neurological Disorders (2009) (7)
Changes of [3H]colchicine binding and protein synthesis in the rat striatum following kainic acid lesions (1978) (7)
Saliva Diagnosis as a Disease Predictor (2020) (7)
Excitotoxins and Animal “Models” of Human Disease (1988) (7)
Possible cortico-hypothalamic glycinergic tract (1980) (7)
Monoamines and their metabolites in Huntington's disease brain: Evidence for decreased catechol-O-methyltransferase activity (1993) (7)
Control of Movement by the Brain (1978) (7)
Protein and RNA synthesis in kainic acid-injected striata (1979) (7)
Increased Uric Acid in the Developing Brain and Spinal Cord Following Cytomegalovirus Infection (1989) (7)
CHAPTER 2 – Amino Acid Hydroxylase Inhibitors (1973) (6)
Axonal transport in nigro-striatal neurones. (1972) (6)
Distribution of Cholinergic Neurons in Human Brain (1987) (6)
Changes in striatal neuron-specific enolase (NSE) and non-neuronal enolase (NNE) following kainic acid administration (1980) (6)
Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid (2015) (6)
Effect of fixatives on rat brain acetylcholinesterase activity (1989) (6)
Preliminary Survey of 4-Amino-5-Imidazolecarboxamide Excretion in Leukemia and Other Illnesses. (1961) (6)
Biochemical Mapping of Specific Neuronal Pathways (1980) (6)
Cysteinesulfinate decarboxylase activity as an index of taurine‐containing structures (1980) (6)
Excitatory amino acids and Alzheimer's disease: Idle thoughts on an exciting subject (1989) (5)
Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS (1986) (5)
Degrees of mental retardation in phenylketonuria. (1961) (5)
Anti-human choline acetyltransferase Fragments Antigen Binding (FAB)-Sepharose chromatography for enzyme purification (1983) (5)
Identification and characterization of a large human brain gene whose expression is increased in Alzheimer disease. (1992) (5)
Brain enzymes in amantadine-treated rats. (1972) (5)
Immunotherapy for Alzheimer's disease. (2004) (4)
GABA Enzymes and Pathways (1982) (4)
Cross-reactivity of antibodies to chicken brain choline acetyltransferase with mammalian enzyme (1982) (4)
Evidence for descending basal forebrain projections anatomical and physiological studies (1986) (4)
Neuronal Mechanisms Involved in Learning and Memory (1978) (4)
Comparative inhibition of biosynthetic processes in rat liver testicular cells by D-, L,-and DL-methadone. (1978) (4)
Central nervous system immune reactions in Alzheimer's disease (1997) (4)
Integration of Motor Functions in the Basal Ganglia (1987) (4)
Cardiovascular events and COX-2 inhibitors. (2001) (4)
Narcotics and rat testicular metabolism. (1979) (4)
Vitamin B6 in mental deficiency: xanthurenic acid excretion in phenylketonurics. (1958) (4)
Excitotoxic amino acids as tools in neurobiology. (1983) (3)
Myocardial Infarction Human Heart Generates Complement Proteins That Are Upregulated and Activated After (1998) (3)
Axonal transport in the habenulo-interpeduncular tract (1977) (3)
Conquering Alzheimer's Disease by Self Treatment. (2018) (3)
GABA accumulation by embryonic chick tectum. (1975) (3)
The Serotonin Neuron (1978) (3)
Postnatal activity of angiotensin converting enzyme in rat brain. (1979) (3)
Prospects for preventing alzheimer's disease (1999) (3)
Effects of folic acid on the phenylalanine tolerance test in phenylketonuria. (1962) (3)
The Prominent Peptides (1987) (3)
Morphine, naloxone and kainic acid neurotoxicity. (1979) (2)
Synaptic morphology in the neostriatum of the rat: Possible serotonergic synapse (1976) (2)
A possible relationship between folic acid neurotoxicity and cholinergic receptors in the pyriform cortex and amygdala. (1983) (2)
The Future Use of Complement Inhibitors for the Treatment of Neurological Diseases (1998) (2)
Intracerebral injections of kainic acid and tetanus toxin: possible models for the signs of chorea and dystonia. (1978) (2)
Vitamin B6 and mental deficiency; the effects of large doses of B6 (pyridoxine) in phenylketonuria. (1959) (2)
Cardiovascular events and COX-2 inhibitors. Authors' reply (2001) (2)
The Dystonias (1988) (2)
Principles of Synaptic Biochemistry (1987) (2)
Inhibitory Properties of the Catecholamines (1961) (2)
Innate Inflammatory Reaction of the Brain in Alzheimer Disease (2020) (2)
METABOLISM OF CATECHOLAMINES, GABA AND ACETYLCHOLINE (1975) (2)
Other Heterocyclic Putative Neurotransmitters: Histamine and Purines (1987) (1)
Central Cholinergic Pathways: The Histochemical Evidence (1988) (1)
Toxicity of p-methoxyphenol to dopamine neurons in the rat substantia nigra (1987) (1)
Complement, neuroinflammation and neuronal degeneration in Alzheimer disease (2001) (1)
γ-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate (1990) (1)
Anti-inflammatory agents as possible protective factors for Alzheimer’s disease: Analysis of relevant epidemiological studies (2001) (1)
Excretion of 4-Amino-5-Imidazolecarboxamide by Various Animal Species. (1961) (1)
Sodium-independent glutamic acid binding in cultured fibroblasts from patients with Huntington's disease (1984) (1)
Steroid therapy in AD (1997) (1)
Immune mechanism in senile plaque formation (1994) (1)
Contents Vol. 3, 1992 (1992) (1)
Effects of morphine on axonal transport in nigrostriatal neurons (1978) (1)
Effect of Cannabinoids and Narcotics on Gonadal Functions (1981) (1)
γ‐GLUTAMYLTRANSFERASE: NORMAL CORTICAL LEVELS IN ALZHEIMER DISEASE (1987) (1)
Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue (1990) (1)
Use of the neurotoxic agents kainic acid and tetanus toxin in the extrapyramidal system. (1979) (1)
Preface (1989) (0)
Kainic acid and neurotransmitter interactions in the basal ganglia. (1980) (0)
Use of NSAIDs for the treatment of dementia (1992) (0)
Cortical Glutaminase , ( 3-Glucuronidase and Glucose Utilization in Alzheimer ' s Disease (2014) (0)
Induction of neuronal tau expression by conditioned medium from activated microglial cells (2012) (0)
Basic Fibroblast Growth Factor in the Substantia nigra in Parkinson’s Disease and Normal Aging (1995) (0)
Basic Behavioral Patterns (1978) (0)
Conversion of typrosine to catecholamines by rat brain slices. (1963) (0)
METHODS FOR DIAGNOSING AND TREATING CACHEXIA (2018) (0)
The Use of Neurotransmitter Indices and the Deoxyglucose Technique to Assess Neurotoxic Effects (1988) (0)
PHYLOGENY AND DEVELOPMENT OF CATECHOLAMINE SYSTEMS IN THE CNS OF VERTEBRATES. 1994. Edited by W.J.A.J. Smeets and A. Reiner. Published by Cambridge University Press. 488 pages. $C 150.00 (1995) (0)
???THE ROLE OF THE NUCLEUS BASALIS OF MEYNERT IN DEMENTIA: REVIEW AND RECONSIDERATION??? (1987) (0)
Chemical Synaptic Transmission at Peripheral Synapses (1978) (0)
Neuroimmune Mechanisms In The Pathogenesis Of Alzheimer’s Disease (2019) (0)
Relation of Aromatic Amino Acids to Excretory Pattern of Schizophrenics (1956) (0)
Perception, Speech, and Consciousness (1978) (0)
Positron Emission Tomography and Neuropsychological Studies in Dementia (2020) (0)
Diencephalic injections of kainic acid produce myo cardial necrosis (1979) (0)
Erratum to: Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2011) (0)
807 Evidence supporting the inflammatory hypothesis of Alzheimer disease (1996) (0)
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases (2016) (0)
Subject Index Vol 3, 1992 (1992) (0)
Familial nature and continuing morbidity of the ALS-PDC of Guam (1998) (0)
Distribution and metabolism of apolipoproteins in the brains with aging and alzheimer-type dementia alzheimer's disease (1994) (0)
The Fine Structure of the Mammalian Brain (1978) (0)
Neuroinflammation, Alzheimer Disease, and Other Aging Disorders (2007) (0)
Inflammation and the lesions of Alzheimer’s disease (2006) (0)
The Building of the Brain and Its Adaptive Capacity (1978) (0)
Putative Transmitters and Transmitter Candidates (1978) (0)
Novel neuroprotective hydrogen sulfide-releasing L-DOPA derivatives for the treatment of Parkinson disease (2010) (0)
Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2011) (0)
Erratum to: Effects of Obovatol on GSH Depleted Glia-Mediated Neurotoxicity and Oxidative Damage (2012) (0)
Immune System Reaction to Model Lesions of Rat Brain (1990) (0)
CORTICALLY PROJECTING BASAL FOREBRAIN NEURONS IN THE ANESTHETIZED RAT OF (2002) (0)
Positron emission tomography and histopathology in Pickʼs disease (1987) (0)
Milk Fat Globule Epidermal Growth Factor 8 ( MFG-E 8 ) Expression in Progressive Supranuclear Palsy (2016) (0)
Excretion of 4-Amino-5-Imidazolecarboxamide by Mental Patients (1963) (0)
Effects of d1-methadone and morphine on developing chick embryo (1978) (0)
Functional Roles of Group II Metabotropic Glutamate Receptors in the Hippocampal CA1 Network (2015) (0)
Aurin tricarboxylic acid may help Alzheimer's disease and other conditions by blocking the MAC of complement (2012) (0)
Immunohistochemical Features which Distinguish Pallido‐Nigro‐Luysial Atrophy from Progressive Supranuclear Palsy (1994) (0)
Iontophoresis of kainic acid (2004) (0)
3-12-06 Glial cell reactions in dementia: Pathophysiology and therapeutic interventions (1997) (0)
Aging and neurotransmitter systems. (1978) (0)