Edna Cukierman
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Edna Cukiermancomputer-science Degrees
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Computer Science
Edna Cukierman's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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Why Is Edna Cukierman Influential?
(Suggest an Edit or Addition)According to Wikipedia, Edna "Eti" Cukierman is a Mexican biochemist who is a professor at the Fox Chase Cancer Center. She serves as co-director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute. Her research investigates pancreatic cancer and the tumor microenvironment.
Edna Cukierman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Taking Cell-Matrix Adhesions to the Third Dimension (2001) (2969)
- Modeling Tissue Morphogenesis and Cancer in 3D (2007) (1585)
- A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1376)
- Cell interactions with three-dimensional matrices. (2002) (907)
- Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis (2011) (613)
- A Rac switch regulates random versus directionally persistent cell migration (2005) (499)
- Integrin Dynamics and Matrix Assembly: Tensin-Dependent Translocation of α5β1 Integrins Promotes Early Fibronectin Fibrillogenesis (2000) (408)
- The ARF1 GTPase-Activating Protein: Zinc Finger Motif and Golgi Complex Localization (1995) (341)
- Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. (2015) (249)
- FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells (2011) (241)
- Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression. (2005) (218)
- Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. (2005) (212)
- Dimensions and dynamics in integrin function. (2003) (211)
- The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. (2007) (184)
- Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. (2018) (182)
- The wound healing, chronic fibrosis, and cancer progression triad. (2014) (182)
- The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase‐activating protein for ARF1 (1997) (178)
- Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts (2006) (165)
- Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. (2008) (163)
- uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion (2003) (156)
- The benefits and challenges associated with the use of drug delivery systems in cancer therapy. (2010) (146)
- Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein. (1996) (124)
- Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. (2010) (113)
- Stromagenesis during tumorigenesis: characterization of tumor-associated fibroblasts and stroma-derived 3D matrices. (2009) (112)
- Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts (2006) (108)
- Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions. (2016) (104)
- The growth and morphological behavior of salivary epithelial cells on matrix protein-coated biodegradable substrata. (2000) (102)
- Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins (2009) (97)
- Targeting Membrane-localized Focal Adhesion Kinase to Focal Adhesions (2003) (93)
- Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A* (2003) (89)
- Integrin Dynamics and Matrix Assembly (2000) (87)
- ADP-ribosylation Factor-directed GTPase-activating Protein (1995) (81)
- Multiple Mechanisms of Telomere Maintenance Exist in Liposarcomas (2005) (79)
- Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression (2018) (64)
- Tumor-Reprogrammed Stromal BCAT1 Fuels Branched Chain Ketoacid Dependency in Stromal-Rich PDAC Tumors (2020) (59)
- Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence (2017) (56)
- Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors (2010) (56)
- Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. (2020) (55)
- PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression. (2005) (54)
- Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland. (2002) (54)
- Re‐engineering the Functions of a Terminally Differentiated Epithelial Cell in Vivo (1999) (54)
- Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner. (2008) (51)
- Cell-matrix adhesions on poly(vinyl alcohol) hydrogels. (2003) (49)
- Requirement for both the Amino-terminal Catalytic Domain and a Noncatalytic Domain for in Vivo Activity of ADP-ribosylation Factor GTPase-activating Protein* (1998) (47)
- Elevated Expression of Stromal Palladin Predicts Poor Clinical Outcome in Renal Cell Carcinoma (2011) (47)
- Tissue compatibility of two biodegradable tubular scaffolds implanted adjacent to skin or buccal mucosa in mice. (2002) (47)
- Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis. (2010) (47)
- Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment (2013) (46)
- A Chemomechanical Model of Matrix and Nuclear Rigidity Regulation of Focal Adhesion Size. (2015) (46)
- Estrogen and Cytochrome P450 1B1 Contribute to Both Early- and Late-Stage Head and Neck Carcinogenesis (2011) (44)
- Miniaturized pre-clinical cancer models as research and diagnostic tools. (2014) (41)
- α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration (2019) (41)
- Three‐dimensional matrix induces sustained activation of ERK1/2 via Src/Ras/Raf signaling pathway (2008) (41)
- Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2. (2019) (39)
- Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling. (2014) (38)
- Cell migration analyses within fibroblast-derived 3-D matrices. (2005) (38)
- Differential Expressions of Adhesive Molecules and Proteases Define Mechanisms of Ovarian Tumor Cell Matrix Penetration/Invasion (2011) (37)
- Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response. (2018) (37)
- Extracellular matrix protein-induced changes in human salivary epithelial cell organization and proliferation on a model biological substratum. (1999) (37)
- Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. (2003) (35)
- Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells. (2018) (34)
- The mesenchymal tumor microenvironment (2012) (32)
- Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland1 (2018) (28)
- Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1. (2001) (28)
- Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses (2012) (28)
- Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma (2016) (27)
- A Visual-Quantitative Analysis of Fibroblastic Stromagenesis in Breast Cancer Progression (2004) (24)
- Preparation of Extracellular Matrices Produced by Cultured Fibroblasts (2002) (24)
- Cancer Associated Fibroblast: Mediators of Tumorigenesis. (2020) (24)
- Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma. (2020) (20)
- Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis (2004) (19)
- Deconstructing tumor heterogeneity: the stromal perspective (2020) (18)
- Using HSV-thymidine kinase for safety in an allogeneic salivary graft cell line. (2001) (17)
- Engineering clinically-relevant human fibroblastic cell-derived extracellular matrices. (2020) (16)
- CD38 in cancer-associated fibroblasts promotes pro-tumoral activity (2020) (16)
- Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours (2020) (15)
- Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix (2020) (15)
- Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction (2020) (14)
- 3‐D Extracellular Matrix from Sectioned Human Tissues (2014) (13)
- Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma (2022) (12)
- Leishmania donovani: characterization of a 38-kDa membrane protein that cross-reacts with the mammalian G-protein transducin. (1991) (12)
- Enhanced aggressiveness of benzopyrene‐induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6) (2015) (10)
- Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma (2021) (8)
- ARF GTPase-activating protein 1. (2002) (8)
- Engineering of tumor microenvironments. (2014) (6)
- NetrinG1+ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress (2021) (4)
- CHAPTER 16. Fibroblastic Cell-derived Extracellular Matrices: A Cell Culturing System to Model Key Aspects of the Tumor Microenvironment (2019) (3)
- Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer (2019) (3)
- A Chemo-Mechanical Model for Extracellular Matrix and Nuclear Rigidity Regulated Size of Focal Adhesion Plaques (2016) (2)
- Novel Insights Into the Role of Inflammation in Promoting Breast Cancer Development (2011) (2)
- A Reflection on How Carcinoma-Associated Fibroblasts Were Recognized as Active Participants of Epithelial Tumorigenesis (2021) (2)
- Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction (2019) (1)
- Tumour development due to stroma permissiveness (2005) (1)
- Meaningful connections: Interrogating the role of physical fibroblast cell-cell communication in cancer. (2022) (1)
- Tumor suppressive and immune-stimulating roles of cholesterol 25-hydroxylase in pancreatic cancer cells. (2022) (1)
- Abstract 2038: NG1/NGL1 engagement supports PDAC development via CAF to PDAC nutrition and CAF-regulated immunosuppression (2019) (1)
- A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment (2022) (1)
- Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition (2022) (1)
- A framework for advancing our understanding of cancer-associated fibroblasts (2020) (1)
- The Few yet Fabp4ulous Pancreatic Stellate Cells Give Rise to Protumoral CAFs. (2022) (1)
- Abstract 3173: NetrinG1's pro-tumor role on stroma-derived extracellular vesicles in pancreatic cancer (2021) (0)
- MultipleMechanisms of TelomereMaintenance Exist in Liposarcomas (2005) (0)
- Abstract 40: Targeting SOX10-deficient cells to reduce resistance to targeted therapy in melanoma (2021) (0)
- Abstract B070: Loss of cytoskeletal protein palladin desensitizes pancreatic cancer associated fibroblast to TGFβ1-dependent desmoplastic induction (2020) (0)
- Tumor-restrictive type III collagen in the breast cancer microenvironment: prognostic and therapeutic implications (2023) (0)
- Capturing relevant extracellular matrices for investigating cell migration (2019) (0)
- Abstract 3725: SETD2 loss in renal carcinoma cells induces the unfolded protein response (2022) (0)
- Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating TGFβ inhibition (2022) (0)
- Abstract 3379: Metabolic influences of pancreatic tumor microenvironment on pancreatic cancer cell's metabolism (2014) (0)
- ID: 191 Fibroblast Activation Protein Confers Enhanced Motility in a Fibroblast Derived 3D Matrix System (2006) (0)
- Concurrent Pulsed Low-Dose-Rate Radiation and Gemcitabine Reduces Desmoplastic Activation in the Pancreatic Tumor Microenvironment (2019) (0)
- ACTR-33. TUMOR TISSUE PENETRATION AND PHARMACODYNAMICS OF ONC201 IN ADULT RECURRENT GLIOBLASTOMA PATIENTS (2018) (0)
- Abstract PR-015: Cancer-associated fibroblasts sustain critical dependency of pancreatic cancer cells on exogenous lipids (2021) (0)
- Abstract PR017: Stromal Netrin G1 ligand (NGL-1): A new modulator of tumorigenesis and immunosuppression in pancreatic cancer (2022) (0)
- Abstract PO-096: The synaptic protein Netrin G1 ligand (NGL-1) modulates tumorigenesis and immunosuppression in pancreatic cancer (2021) (0)
- Abstract PR-006: Pulsed low-dose-rate radiation (PLDR) limits pancreatic pro-tumor stroma aggravation: Pre-clinical basis for an ongoing PLDR trail (2021) (0)
- Abstract 2979: Inhibition of palladin in cancer associated fibroblast impedes pancreatic ductal adenocarcinoma associated desmoplasia (2017) (0)
- Abstract 1571: Cancer associated fibroblasts sustain critical dependency of pancreatic cancer cells on exogenous lipids (2022) (0)
- Author response: Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence (2016) (0)
- Author Correction: Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction (2020) (0)
- Abstract 3649: Stromal netrinG1-ligand (NGL1) constitutes a new modulator of pancreatic cancer immunosuppression (2022) (0)
- Abstract 2913: Transcriptional reprogramming of pancreatic stroma induces metabolic changes in pancreatic tumor cells (2015) (0)
- Author's response to reviews Title: FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells Authors: (2011) (0)
- Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. (2023) (0)
- Abstract 6794: SETD2 loss in renal cell carcinoma generates peptides from aberrantly translated retained introns (2023) (0)
- Abstract PR004: NetrinG1’s pro-tumor role on stroma-derived extracellular vesicles in pancreatic cancer (2021) (0)
- Abstract B39: Estrogen and cytochrome P450 1B1 contribute to early-stage head and neck carcinogenesis (2010) (0)
- Abstract LT019: The synaptic protein netrin G1 ligand (NGL-1) modulates the immunosuppressive environment in pancreatic cancer (2021) (0)
- Abstract 116: Stromal expression of the synaptic protein netrin G1 ligand (NGL-1) promotes tumorigenesis and immunosuppression in pancreatic cancer (2021) (0)
- Abstract 137: Tumor-associated ECM induces renal cell carcinoma tumorigenic responses via α6β1-integrin regulation of ITPKA (2014) (0)
- Abstract 1115: A discrete tuning of α5β1 integrin activity sustains the tumor-ECM induced fibroblastic activation in pancreatic cancer stroma (2014) (0)
- Abstract C047: Phospholipid scramblase TMEM16F in cancer associated fibroblasts regulates trogocytosis to sustain critical dependency of pancreatic cancer cells on exogenous lipids (2022) (0)
- Abstract 3171: Stromal palladin is a poor prognostic marker in renal cell carcinoma (2011) (0)
- Abstract IA-03: ECM-dependent CAF functions in pancreatic cancer nutritional support & immunosuppression (2020) (0)
- Abstract C06: Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer (2019) (0)
- Abstract SY30-03: Desmoplastic matrices: Enablers of a synapse-like axis in pancreatic cancer (2019) (0)
- Lorazepam stimulates IL-6 production and is associated with poor survival outcomes in pancreatic cancer (2023) (0)
- Abstract LB-109: PDeX (Patient Derived eXplant) models to determine the basis for response to targeted agents in prostate cancer (2017) (0)
- Abstract P6-02-05: A novel culturing 3-D model to evaluate the role of tumor microenvironment in IBC. (2012) (0)
- Effects of losartan and vitamin D on outcomes in metastatic pancreatic adenocarcinoma. (2023) (0)
- Extracellular Matrix-Controlled Contractile 3D Perpendicular Lateral Protrusions Enable Desmoplastic Expansion (2021) (0)
- Abstract 438: Cholesterol biosynthesis is a critical metabolic dependency in pancreatic cancer (2017) (0)
- Abstract 5089: Desmoplastic stroma affects growth and invasion of progressively mutated human pancreatic cancer cellsin vitro (2015) (0)
- Author Correction: Force-exerting perpendicular lateral protrusions in fibroblastic cell contraction (2020) (0)
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