Ed Harlow
#58,093
Most Influential Person Now
American molecular biologist
Ed Harlow's AcademicInfluence.com Rankings
Ed Harlowbiology Degrees
Biology
#2772
World Rank
#4355
Historical Rank
#1206
USA Rank
Molecular Biology
#606
World Rank
#621
Historical Rank
#160
USA Rank
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Chemistry Biology
Ed Harlow's Degrees
- Bachelors Chemistry University of California, Berkeley
Why Is Ed Harlow Influential?
(Suggest an Edit or Addition)According to Wikipedia, Ed Harlow is an American molecular biologist. Harlow received the Ph.D. degree from the Imperial Cancer Research Fund Laboratories in London. Harlow is professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.
Ed Harlow's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. (1989) (2983)
- New functional activities for the p21 family of CDK inhibitors. (1997) (1503)
- Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product (1988) (1451)
- Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. (1989) (1201)
- Distinct roles for cyclin-dependent kinases in cell cycle control. (1993) (1156)
- Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. (2002) (1060)
- The retinoblastoma protein is phosphorylated during specific phases of the cell cycle (1989) (1021)
- Monoclonal antibodies specific for simian virus 40 tumor antigens (1981) (954)
- p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 (1994) (927)
- A family of human cdc2‐related protein kinases. (1992) (899)
- Identification of G1 kinase activity for cdk6, a novel cyclin D partner (1994) (870)
- Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 (1996) (797)
- The retinoblastoma tumour suppressor in development and cancer (2002) (783)
- Cellular targets for transformation by the adenovirus E1A proteins (1989) (708)
- NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (2000) (633)
- A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F (1992) (618)
- Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition (1995) (560)
- Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. (1993) (545)
- The retinoblastoma protein binds to a family of E2F transcription factors (1993) (493)
- Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. (1993) (485)
- Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. (1993) (480)
- Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein (1993) (476)
- Shared role of the pRB-related p130 and p107 proteins in limb development. (1996) (470)
- Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. (1992) (451)
- Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase (1991) (419)
- Differential regulation of E2F transactivation by cyclin/cdk2 complexes. (1994) (419)
- Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. (1996) (419)
- Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins (1992) (409)
- Association of adenovirus early-region 1A proteins with cellular polypeptides (1986) (402)
- Point mutational inactivation of the retinoblastoma antioncogene. (1989) (397)
- Cyclin-dependent kinases: a family portrait (2009) (378)
- Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (1998) (374)
- Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F (1992) (367)
- Targeted disruption of p107: functional overlap between p107 and Rb. (1996) (367)
- Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products (1985) (360)
- The cdk2 kinase is required for the G1-to-S transition in mammalian cells. (1993) (345)
- The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. (1991) (343)
- Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice (1998) (334)
- The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. (1990) (324)
- The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus (1989) (318)
- Nuclear organization of DNA replication in primary mammalian cells. (2000) (315)
- Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein (1990) (305)
- A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. (2004) (285)
- Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. (1997) (279)
- p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. (1995) (276)
- Proteome-scale purification of human proteins from bacteria (2002) (271)
- In vivo association of E2F and DP family proteins (1995) (266)
- pRB plays an essential role in cell cycle arrest induced by DNA damage. (1998) (255)
- Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. (1998) (238)
- Two regions of the adenovirus early region 1A proteins are required for transformation (1988) (234)
- Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. (1992) (233)
- Identification of small molecule inhibitors of pyruvate kinase M2. (2010) (228)
- A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells (1989) (224)
- Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. (1998) (214)
- Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (1992) (214)
- RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest (2001) (204)
- Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. (1996) (182)
- Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. (2001) (180)
- Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells (1980) (178)
- Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (1993) (168)
- Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase (1993) (165)
- Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53 (1985) (162)
- Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes (1993) (162)
- Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. (1996) (161)
- Tumour-suppressor genes: evolving definitions in the genomic age (1997) (161)
- Opposing roles of pRB and p107 in adipocyte differentiation. (2000) (161)
- Adenovirus E1A targets key regulators of cell proliferation. (1992) (159)
- Distinct sub‐populations of the retinoblastoma protein show a distinct pattern of phosphorylation. (1994) (157)
- Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1 (1996) (152)
- The pRB‐related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. (1995) (148)
- Kinase requirements in human cells: III. Altered kinase requirements in VHL−/− cancer cells detected in a pilot synthetic lethal screen (2008) (147)
- Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides (1991) (136)
- Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins. (1987) (131)
- A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes (2001) (131)
- Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. (2000) (128)
- The retinoblastoma protein physically associates with the human cdc2 kinase (1992) (126)
- Specific regulation of E2F family members by cyclin-dependent kinases (1997) (122)
- Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. (2007) (122)
- A kinase shRNA screen links LATS2 and the pRB tumor suppressor. (2011) (122)
- Adenovirus E1A makes two distinct contacts with the retinoblastoma protein (1992) (116)
- High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy (2011) (104)
- Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen (1982) (103)
- Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production (1986) (103)
- Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells (1981) (96)
- Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. (1995) (91)
- SV40 T antigen binds specifically to a cellular 53 K protein in vitro (1981) (89)
- Kinase requirements in human cells: I. Comparing kinase requirements across various cell types (2008) (87)
- The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2 (1993) (86)
- Dp1 is required for extra-embryonic development (2003) (79)
- Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization (1991) (76)
- Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. (1991) (69)
- Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 (2010) (67)
- Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs (1997) (64)
- Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein (1994) (63)
- Disruption of Retinoblastoma Protein Family Function by Human Papillomavirus Type 16 E7 Oncoprotein Inhibits Lens Development in Part through E2F-1 (1999) (60)
- Adenovirus E1A is associated with a serine/threonine protein kinase (1991) (52)
- An Inverted Repeat Motif Stabilizes Binding of E2F and Enhances Transcription of the Dihydrofolate Reductase Gene (*) (1995) (46)
- Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells (2008) (43)
- p16 inhibition of transformed and primary squamous epithelial cells. (1996) (43)
- Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases. (1990) (41)
- Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines. (2013) (41)
- Expression of the Retinoblastoma Protein in Low-Grade B-Cell Lymphoma: Relationship to Cyclin D1 (1996) (39)
- Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. (2005) (39)
- Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. (1996) (38)
- GRK3 is essential for metastatic cells and promotes prostate tumor progression (2014) (36)
- Nuclear Reorganization of Mammalian DNA Synthesis Prior to Cell Cycle Exit (2004) (33)
- Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40‐transformed cells. (1983) (33)
- Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines (2008) (33)
- Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis (2010) (32)
- Uniform Nomenclature for Monoclonal Antibodies Directed Against Virus-Coded Proteins of Simian Virus 40 and Polyoma Virus (1982) (32)
- Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft (2001) (30)
- The cyclin-dependent kinase family. (1991) (29)
- Monoclonal Antibodies Specific for Adenovirus Early Region lA Proteins : Extensive Heterogeneity in Early Region 1 A Products (28)
- Cellular proteins that are targetted by DNA tumor viruses for transformation. (1989) (28)
- Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells. (1980) (26)
- Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells. (2005) (26)
- No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice (1999) (24)
- Identification of small molecule inhibitors of pyruvate kinase M 2 (2010) (23)
- Purification and analysis of CIP/KIP proteins. (1997) (18)
- Growth suppression by members of the retinoblastoma protein family. (1994) (15)
- High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability (2010) (13)
- Cellular proteins that are targets for transformation by DNA tumour viruses. (1990) (12)
- Polyomavirus Small tAntigen: Overproduction inBacteria, Purification, andUtilization forMonoclonal andPolyclonal Antibody Production (1986) (11)
- Transcriptional inhibition by the retinoblastoma protein. (1993) (11)
- Differential regulation of E 2 F t r a n s-activation by cyclin / cdk 2 complexes (2007) (9)
- In-Vitro Assays to Detect the Interaction of DNA Tumor Virus Transforming Proteins with the Retinoblastoma Protein (1989) (8)
- A research shortcut from a common cold virus to human cancer (1996) (8)
- UICC study group on basic and clinical cancer research: Cell‐cycle control: A target for therapy? (1995) (7)
- Immunoblot affinity purification (2005) (5)
- Anti-oncogenes and the negative regulation of cell growth. (1988) (5)
- Targeted disruption of pi07: functional overlap between pl07 and Rb (1996) (5)
- Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells. (2000) (3)
- Specific Regulation of E2F Family Members by Cyclin-Dependent Kinases (1997) (2)
- No Effect of Loss of E 2 F 1 on Liver Regeneration or Hepatocarcinogenesis in C 57 BL / 6 J or C 3 H / HeJ Mice (1999) (1)
- Cellular Proteins Implicated in Transformation by Adenovirus and Other DNA Tumor Viruses (1989) (1)
- Cdk6: Cyclin-dependent kinase-6 (vertebrates) (PLSTIIRE) (1995) (1)
- Cellular Targets for Transformation by DNA Tumor Viruses (1990) (1)
- Monoclonal Antibodies Specific for Adenovirus Early Region lA (0)
- Abstract LB-90: Essential kinases for human metastatic cells pertaining to c-Met signaling (2012) (0)
- Abstract A200: Differential kinase requirements of human cell lines pertaining to metastasis and c‐Met signaling (2009) (0)
- Complex ofSimian Virus 40Large-T Antigen andHost53,000- Molecular-Weight Protein inMonkeyCells (1981) (0)
- TheRetinoblastoma Protein BindstoaFamily ofE2F Transcription Factors (1993) (0)
- Abstract LB-189: GRK3 is essential for metastatic cells and promotes prostate cancer progression (2014) (0)
- Adenovirus ElAIsAssociated withaSerine/Threonine (1991) (0)
- Cdk3: Cyclin-dependent kinase-3 (vertebrates) (1995) (0)
- Autophagy and Tamoxifen Resistance in Breast Cancer. (2009) (0)
- Sequences within theConserved Cyclin BoxofHumanCyclin A AreSufficient forBinding toandActivation ofcdc2Kinase (1993) (0)
- Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division. (1992) (0)
- General Discussion .1. the Role of Protooncogenes in Amphibian Development (1990) (0)
- Inhibition ofE2F-1Transactivation byDirect Binding oftheRetinoblastoma Protein (1993) (0)
- blocks cell cycle progression in G1. Expression of dominant-negative mutant DP-1 (2013) (0)
- Molecular Cloning andInVitro Expression ofacDNA Clonefor HumanCellular TumorAntigen p53 (1985) (0)
- - Cdk5: Cyclin-dependent kinase 5 (vertebrates) (PSSALRE) (1995) (0)
- Saccharomyces cerevisiaeprotein-encoding clones for Approaching a complete repository of sequence-verified data (2007) (0)
- MISCUES IN THE pRB SIGNALING PATHWAY (1996) (0)
- General Discussion .2. Regulation of the Eukaryotic Cell-Cycle (1990) (0)
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