Edward Rebar
#56,741
Most Influential Person Now
American biologist
Edward Rebar's AcademicInfluence.com Rankings
Edward Rebarbiology Degrees
Biology
#6425
World Rank
#9133
Historical Rank
#2068
USA Rank
Molecular Biology
#2637
World Rank
#2678
Historical Rank
#293
USA Rank
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Biology
Edward Rebar's Degrees
- Bachelors Biology University of California, Berkeley
- PhD Molecular Biology Stanford University
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Why Is Edward Rebar Influential?
(Suggest an Edit or Addition)According to Wikipedia, Edward John Rebar is an American biologist, and is Senior Vice President and Chief Technology Officer of Sana Biotechnology. Education Edward John Rebar earned a Bachelor of Science in biochemistry from Rutgers University. He completed a Doctor of Philosophy in biophysics and structural biology from Massachusetts Institute of Technology. His 1997 dissertation was titled Selection studies of zinc finger-DNA recognition. His doctoral advisor was Carl Pabo. Rebar worked as a post-doctoral fellow at the University of California, Berkeley.
Edward Rebar's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A TALE nuclease architecture for efficient genome editing (2011) (1947)
- Genome editing with engineered zinc finger nucleases (2010) (1937)
- Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases (2009) (1054)
- An improved zinc-finger nuclease architecture for highly specific genome editing (2007) (1033)
- Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases (2008) (1010)
- Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases (2009) (926)
- Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases (2008) (922)
- Precise genome modification in the crop species Zea mays using zinc-finger nucleases (2009) (853)
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (675)
- Targeted Genome Editing Across Species Using ZFNs and TALENs (2011) (633)
- In vivo genome editing restores hemostasis in a mouse model of hemophilia (2011) (544)
- Genetic engineering of human ES and iPS cells using TALE nucleases (2011) (489)
- A rapid and general assay for monitoring endogenous gene modification. (2010) (486)
- A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. (2012) (434)
- Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. (1994) (422)
- Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases (2008) (377)
- PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis (2002) (313)
- Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. (2010) (295)
- Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells. (2015) (289)
- DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation (2011) (284)
- Translating Dosage Compensation to Trisomy 21 (2013) (280)
- Induction of angiogenesis in a mouse model using engineered transcription factors (2002) (272)
- Regulation of an Endogenous Locus Using a Panel of Designed Zinc Finger Proteins Targeted to Accessible Chromatin Regions (2001) (248)
- In vivo genome editing of the albumin locus as a platform for protein replacement therapy. (2015) (244)
- Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells (2011) (241)
- Toward eliminating HLA class I expression to generate universal cells from allogeneic donors. (2013) (232)
- Targeted transgene integration in plant cells using designed zinc finger nucleases (2009) (221)
- Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations (2014) (214)
- Trait stacking via targeted genome editing. (2013) (209)
- Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site (2000) (186)
- Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo (2018) (177)
- Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases (2012) (162)
- PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. (2002) (150)
- BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells (2010) (148)
- Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases (2011) (144)
- Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases (2011) (131)
- Functional footprinting of regulatory DNA (2015) (123)
- Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells (2017) (119)
- Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease (2019) (105)
- Improved specificity of TALE-based genome editing using an expanded RVD repertoire (2015) (90)
- Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (84)
- Mammalian interspecies substitution of immune modulatory alleles by genome editing (2016) (81)
- Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors. (2003) (76)
- Engineered Zinc Finger–Activating Vascular Endothelial Growth Factor Transcription Factor Plasmid DNA Induces Therapeutic Angiogenesis in Rabbits With Hindlimb Ischemia (2004) (74)
- Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma. (2015) (73)
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations (2011) (70)
- Transcriptional activation of Brassica napus β-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor. (2012) (65)
- An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease (2010) (60)
- Diversifying the structure of zinc finger nucleases for high-precision genome editing (2019) (58)
- Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy (2006) (57)
- An engineered VEGF‐activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced‐age mice (2006) (56)
- Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates. (2016) (54)
- Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities. (1996) (50)
- Elevation of seed alpha-tocopherol levels using plant-based transcription factors targeted to an endogenous locus. (2004) (41)
- Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects (2016) (37)
- Designed transcription factors as tools for therapeutics and functional genomics. (2002) (36)
- Activation of Vascular Endothelial Growth Factor A Transcription in Tumorigenic Glioblastoma Cell Lines by an Enhancer with Cell Type-specific DNase I Accessibility* (2002) (34)
- Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application (2016) (34)
- Enhancing gene editing specificity by attenuating DNA cleavage kinetics (2019) (33)
- Development of pro-angiogenic engineered transcription factors for the treatment of cardiovascular disease (2004) (24)
- Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo (2002) (21)
- Gene editing of the multi-copy H2A.B gene and its importance for fertility (2019) (21)
- A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart (2012) (20)
- Persistent repression of tau in the brain using engineered zinc finger protein transcription factors (2021) (18)
- Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing (2016) (16)
- Gene regulation in planta by plant-derived engineered zinc finger protein transcription factors (2005) (16)
- A Potential Therapy for Beta-Thalassemia (ST-400) and Sickle Cell Disease (BIVV003) (2017) (10)
- Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies (2015) (10)
- Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells (2014) (6)
- ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates (2015) (5)
- 758. Towards Gene Knock out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases (ZFNs) (2006) (5)
- 974. Towards Gene Knock out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases (ZFNs) (2005) (5)
- 53. From GWAS To the Clinic: Genome-Editing the Human BCL11A Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies (2015) (4)
- Clonal Analysis of Human Bone Marrow CD34+ Cells Edited By BCL11A-Targeting Zinc Finger Nucleases Reveals Clinically Relevant Levels of Fetal Globin Expression in Edited Erythroid Progeny (2015) (4)
- In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9 (2012) (4)
- Novel approaches to controlling transcription. (2002) (4)
- 85. Development of Zinc Finger Nucleases for Therapeutic Gene Correction of Sickle Cell Anemia (2005) (4)
- Selection studies of zinc finger-DNA recognition (1997) (4)
- A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart. (2012) (4)
- Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease (2015) (3)
- 329 GENETIC TARGETING OF THE PORCINE α1,3-GALACTOSYLTRANSFERASE GENE IN FETAL FIBROBLAST CELLS USING ZINC FINGER NUCLEASES (2011) (3)
- Erratum: Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells (Stem Cell Reports (2014) 2 (838-852)) (2014) (3)
- Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma (2014) (3)
- Abstract LB144: Overexpression of CD47 protects hypoimmune CAR T cells from innate immune cell killing (2021) (2)
- HLA and TCR Knockout by Zinc Finger Nucleases: Toward “off-the-Shelf” Allogeneic T-Cell Therapy for CD19+ Malignancies. (2010) (2)
- ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A (2013) (2)
- 239. Preclinical Studies for the First Hematopoietic Stem Cell (HSC) Gene Editing Trial: Phase 1 Study of Beta-Thalassemia With Autologous Transplantation of Zinc Finger Nuclease-Treated HSC To Upregulate Fetal Hemoglobin (2015) (2)
- Targeted Killing of Glioblastoma Multiforme In Vivo by IL-13 Zetakine Redirected CTLs Made Glucocorticoid Resistant with Zinc Finger Nucleases. (2007) (2)
- 387. Advantageous Properties of the piggyBac Transposon System for Gene Transfer in Human Cells (2006) (1)
- Gene editing of the multi-copy H2A.B gene and its importance for fertility (2019) (1)
- Enhancing gene editing specificity by attenuating DNA cleavage kinetics (2019) (1)
- Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity (2021) (1)
- Phenotypic Correction of a Mouse Model of Hemophilia B by In Vivo Genetic Correction of the F9 Gene (2010) (1)
- A7 Drug discovery approach for rare neurological diseases: using novel zinc finger protein technology to develop potential therapy for huntington’s disease (2016) (1)
- into a safe harbor locus in the human genome isogenic settings using zinc finger nuclease-driven transgenesis Functional genomics , proteomics , and regulatory DNA analysis in Material Supplemental (2010) (0)
- 564. Finding the Needle in a Haystack: Precise Genome Editing With a Multi-Reporter Selection Systems (2015) (0)
- Integration et expression ciblees de sequences d'acides nucleiques exogenes (2006) (0)
- 931. Enhanced Cardiac Muscle Contractility Achieved by Engineered Zinc Finger Transcriptional Repressors of Phospholamban (2004) (0)
- 1049. Engineered ZFPs Can Prevent Limb Loss in Mice (2004) (0)
- Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS (2017) (0)
- from allogeneic donors Towards eliminating HLA class I expression to generate universal cells (2013) (0)
- 641. Highly Efficient, ZFN-Driven Knockout of Surface Expression of the T-Cell Receptor and HLA Class I Proteins in Human T-Cells for Enhancing Allogeneic Adoptive Cell Therapies (2016) (0)
- Abstract 5598: Engineered hypoimmune allogeneic CAR T cells as potential off-the-shelf CAR T cell immunotherapies (2022) (0)
- 115. Correction of the Sickle-Cell Disease Mutation in Human Hematopoietic Stem/Progenitor Cells (2015) (0)
- 659. Development of Designed Zinc Finger Protein Transcriptional Regulators for Use in Multi-Factor Therapeutic Angiogenesis (2004) (0)
- Running title: HLA-A disruption in donor cells (2017) (0)
- Human tissue with adult stem cell properties derived from pluripotent stem cells. (2014) (0)
- TARGETED MODIFICATION OF THE RAT GENOME USING ZINC FINGER NUCLEASES (2009) (0)
- Diversifying the structure of zinc finger nucleases for high-precision genome editing (2019) (0)
- Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo (2018) (0)
- VPAAMAERPFQCRICMRNFS RSDSLSV HIRTHTGEKPFACDICGRKFA HNDSRKN HTKIHTGEKPFQCRICMRKFA DQSNLRA HTKIHTHPRAPIPKPFQCRICMRNFS RSANL AR HIRTHTGEKPFACDICGRKFA QSGNLAR HTKIHLRGS VPAAMAERPFQCRICMRNFS RSDHLSA HIRTHTGEKPFACDICGRKFA SYWSRTV HTKIHTHPRAPIPKPFQCRICMRNFS RSDALSV HIRTHTGEKPFACDICGRKFA DSSHRT R HTKIHTGSQK (2011) (0)
- 555. Large-Scale, Flow-Based Electroporation To Deliver Engineered Zinc Finger Protein Nucleases That Mediate High-Efficiency Disruption of the Human CCR5 Gene (2006) (0)
- Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b (2022) (0)
- 77. Clinical Scale Zinc Finger Nuclease (ZFN)-Driven Gene-Editing of PD-1 in Tumor Infiltrating Lymphocytes (TIL) for the Potential Treatment of Metastatic Melanoma (2015) (0)
- 302. Engineered Zinc Finger Transcription Factors: A Platform for Therapeutic Gene Regulation with Exquisite Specificity (2004) (0)
- Repression of vascular endothelial growth factor-A over-expression in glioblastoma cells using engineered zinc-finger transcription factors (2004) (0)
- “Designer” Cells for Cellular Immunotherapy: Zinc Finger Nuclease (ZFN) Stimulated Targeted Recombination for the Simultaneous Disruption of the Endogenous Glucocorticoid Receptor and Site-Specific Addition of the IL13-Zetakine. (2006) (0)
- 787. Engineered Fok I Heterodimers for Enhanced Zinc Finger Nuclease Specificity (2006) (0)
- 43. Targeting the Biology of Heart Disease: Engineered Zinc Finger Protein Repressors of Phospholamban as a Potential Therapy for Congestive Heart Failure (2005) (0)
- 531. Activation of VEGF by Engineered Zinc Finger Transcriptional Activators: A Novel Therapeutic Approach to Diabetic Neuropathy (2004) (0)
- 379. New Zinc Finger Protein Nuclease Architectures for More Efficient Gene Modification Therapies (2005) (0)
- 107. Use of Adeno-Associated Viral Vectors for Effective Delivery of Engineered Zinc Finger Protein Transcription Factors (2004) (0)
- 1072. Superactivation of the SR|[alpha]| and CMV Promoters Using Designed Zinc Finger Proteins (2005) (0)
- Tal-effector (tale) dna-binding polypeptides and uses thereof (2011) (0)
- Selection of binding areas for zinc finger proteins and design methods for zinc finger proteins capable of binding to such pre-selected areas (2000) (0)
- Targeted Gene Modification In Hematopoietic Stem Cells: A Potential Treatment For Thalassemia and Sickle Cell Anemia (2013) (0)
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