Edward Tuddenham | Academic Influence

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Edward Tuddenham

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Philosophy

Edward Tuddenham's Degrees

Doctorate Medicine Harvard University

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According to Wikipedia, Edward G. D. Tuddenham FMedSci is considered one of the world's leading haematologists having authored over 200 papers in the field. He gained his Bachelor of Medicine, Bachelor of Surgery at the University of London in 1968 and his Membership of the Royal College of Physicians in 1975. Up until 2005 was head of the Haemostasis and Thrombosis Research Group at Imperial College. Professor Tuddenham is a pioneer in the field of haemophilia and was responsible, along with Frances Rotblat, for the purification and cloning of the factor VIII gene, which led to the highly effective and safe treatments available to haemophilia sufferers today. In more recent years, he has been actively involved in developing gene therapy for haemophilia. The first successful use of gene transfer to convert severe to mild haemophilia B was reported by his group in December 2011.He retired from Directorship of the Katharine Dormandy Centre in July 2011 and is now Emeritus Professor of Haemophilia at University College London. He continues to work in the Haemophilia Centre at the Royal Free Hospital on gene therapy clinical trials, with the goal of curing all forms of haemophilia.

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Edward Tuddenham's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. (2011) (1558)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 (2004) (1140)
The hemophilias--from royal genes to gene therapy. (2001) (969)
Long-term safety and efficacy of factor IX gene therapy in hemophilia B. (2014) (942)
Structure of human factor VIII (1984) (831)
Expression of active human factor VIII from recombinant DNA clones (1984) (657)
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. (2006) (388)
Haemophilia A: Mutation Type Determines Risk of Inhibitor Formation (1995) (350)
Distribution of factor VIII mRNA and antigen in human liver and other tissues (1985) (296)
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates. (2007) (265)
High Prevalence of Elevated Factor VIII Levels in Patients Referred for Thrombophilia Screening: Role of Increased Synthesis and Relationship to the Acute Phase Reaction (1997) (246)
The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4 (1998) (240)
Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA. (2011) (231)
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant. (2013) (231)
Crystal structure of the extracellular region of human tissue factor (1994) (205)
Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene (1985) (204)
HLA Genotype of Patients with Severe Haemophilia A due to Intron 22 Inversion with and without Inhibitors of Factor VIII (1997) (202)
Detection and sequence of mutations in the factor VIII gene of haemophiliacs (1985) (195)
Definition of the Bleeding Tendency in Factor XI-Deficient Kindreds–A Clinical and Laboratory Study (1995) (180)
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene. (1991) (173)
Environmental and genetic factors influencing inhibitor development. (2004) (165)
Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease (1982) (163)
Codon optimization of human factor VIII cDNAs leads to high-level expression. (2011) (163)
Relationship between hemostatic abnormalities and neuroendocrine activity in heart failure. (1994) (162)
Factor VII deficiency and the FVII mutation database (2001) (157)
The Molecular Genetics of Haemostasis and Its Inherited Disorders (1994) (157)
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition. (1994) (150)
Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene (1991) (143)
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. (2004) (142)
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. (2008) (140)
Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. (1988) (138)
A new polymorphism in the factor VIII gene for prenatal diagnosis of hemophilia A. (1986) (135)
Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1 (2004) (135)
Relationships of Plasma Viscosity, Coagulation and Fibrinolysis to Coronary Risk Factors and Angina (1991) (135)
Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies. (1985) (122)
Inherited Factor VII Deficiency: Molecular Genetics and Pathophysiology (1997) (122)
Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. (2006) (120)
Molecular etiology of factor VIII deficiency in hemophilia A (1995) (120)
Clinical experience with polyelectrolyte-fractionated porcine factor VIII concentrate in the treatment of hemophiliacs with antibodies to factor VIII. (1984) (108)
A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. (2005) (99)
Complete Inhibition of Acute Humoral Rejection Using Regulated Expression of Membrane‐tethered Anticoagulants on Xenograft Endothelium (2004) (99)
Menorrhagia in adolescents with inherited bleeding disorders. (2010) (97)
Molecular evolution of the vertebrate blood coagulation network (2003) (91)
Haemostatic problems in liver disease. (1986) (91)
Von Willebrand factor multimer patterns in von Willebrand's disease (1983) (91)
Thromboelastography, whole-blood haemostasis and recurrent miscarriage. (2003) (88)
Analysis of the F8 Gene in Individuals with High Plasma Factor VIII:C Levels and Associated Venous Thrombosis (1998) (85)
Inherited Factor VII Deficiency: Genetics and Molecular Pathology (1995) (84)
Desmopressin and bleeding time in patients with cirrhosis. (1985) (82)
Inherited Factor X Deficiency: Molecular Genetics and Pathophysiology (1997) (81)
Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene (1994) (80)
Synthesis and Release of Factor VIII by Cultured Human Endothelial Cells (1981) (72)
The Factor VIII Mutation Database on the World Wide Web: the haemophilia A mutation, search, test and resource site. HAMSTeRS update (version 3.0) (1997) (72)
A G → A substitution in an HNF I binding site in the human α-fetoprotein gene is associated with hereditary persistence of α-fetoprotein (HPAFP) (1993) (72)
Coagulation and fibrosis in chronic liver disease (2008) (70)
Adeno-Associated Mediated Gene Transfer for Hemophilia B:8 Year Follow up and Impact of Removing "Empty Viral Particles" on Safety and Efficacy of Gene Transfer (2018) (69)
Epidemiology of coagulation disorders. (1992) (67)
Assessing thrombotic risk (1998) (66)
Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. (2008) (64)
Molecular defects in CRM+ factor VII deficiencies: modelling of missense mutations in the catalytic domain of FVII (1994) (63)
The properties of factor VIII coagulant activity prepared by immunoadsorbent chromatography. (1979) (59)
The genetic basis of inhibitor development in haemophilia A (1998) (58)
Monoclonal antibodies to human procoagulant factor VIII. (1983) (55)
Coronary Thrombosis and the Platelet Glycoprotein IIIA Gene PLA2 Polymorphism (1998) (55)
Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. (2004) (54)
Localization of factor VIIIC: antigen in guinea‐pig tissues and isolated liver cell fractions (1984) (53)
Homozygous protein C deficiency with delayed onset of symptoms at 7 to 10 months. (1989) (53)
Advances in Gene Therapy for Hemophilia. (2017) (50)
Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis. (2004) (49)
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage (2011) (46)
Structure of human factor VIII. Nature (1984) (45)
Factor VIII – novel insights into form and function (2002) (45)
An immunoradiometric assay for human factor VIII/von Willebrand factor (VIII:vWF) using a monoclonal antibody that defines a functional epitope (1985) (44)
Solution structure of the major factor VIII binding region on von Willebrand factor. (2014) (43)
Factor VIII gene mutations found by a comparative study of SSCP, DGGE and CMC and their analysis on a molecular model of factor VIII protein (1997) (42)
Changes in the levels of factor VIII and von Willebrand factor in the puerperium (2012) (42)
The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103. (1997) (42)
Energetic contributions and topographical organization of ligand binding residues of tissue factor. (1995) (41)
Contact activation in shock caused by invasive group A Streptococcus pyogenes (2000) (41)
Immunologic studies of factor VIII coagulant activity (VIII:C) 1. Assays based on a haemophilic and an acquired antibody to VIII:C. (1981) (40)
Monitoring low dose recombinant factor VIIa therapy in patients with severe factor XI deficiency undergoing surgery (2011) (39)
Analysis of the essential sequences of the factor VIII gene in twelve haemophilia A patients by single‐stranded conformation polymorphism (1994) (36)
ANTENATAL DIAGNOSIS AND CARRIER DETECTION OF HAEMOPHILIA A USING FACTOR VIII GENE PROBE (1985) (36)
Detection of missense mutations by single-strand conformational polymorphism (SSCP) analysis in five dysfunctional variants of coagulation factor VII. (1993) (36)
Severe perinatal thrombosis in double and triple heterozygous offspring of a family segregating two independent protein S mutations and a protein C mutation. (1996) (35)
Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A (2006) (34)
Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter (1994) (34)
Novel, human cell line‐derived recombinant factor VIII (human‐cl rhFVIII; Nuwiq®) in adults with severe haemophilia A: efficacy and safety (2016) (33)
A Two-Site, Monoclonal Antibody-Based Immunoassay for von Willebrand Factor -Demonstration that vWF Function Resides in a Conformational Epitope (1986) (33)
The impact of sport on health status, psychological well‐being and physical performance of adults with haemophilia (2016) (32)
GO-8: Preliminary Results of a Phase I/II Dose Escalation Trial of Gene Therapy for Haemophilia a Using a Novel Human Factor VIII Variant (2018) (32)
von Willebrand factor and its disorders: an overview of recent molecular studies. (1989) (32)
Factor VIII Ise (R2159C) in a Patient with Mild Hemophilia A, an Abnormal Factor VIII with Retention of Function but Modification of C2 Epitopes (1997) (31)
Thrombin generation assay identifies individual variability in responses to low molecular weight heparin in pregnancy: implications for anticoagulant monitoring (2015) (31)
The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS (1996) (30)
Expression of factor VII by muscle cells in vitro and in vivo following direct gene transfer: modelling gene therapy for haemophilia. (1995) (30)
Recent advances in developing specific therapies for haemophilia (2018) (29)
Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency (2009) (28)
Factor Vila and other Haemostatic Variables following Bone Marrow Transplantation (1994) (28)
Multicenter Comparison of von Willebrand Factor Multimer Sizing Techniques (1985) (26)
A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP). (1993) (26)
Preparation of factor IX deficient human plasma by immunoaffinity chromatography using a monoclonal antibody. (1982) (25)
The effect of liver disease on factors V, VIII and protein C (1985) (23)
Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI‐CD4 and hirudin‐CD4 fusion proteins (2001) (23)
Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy. (1995) (23)
Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B (2010) (23)
A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier syndrome (BSS) (2005) (22)
4 Factor VIII and haemophilia A (1989) (22)
Coagulation Factor VII Gln100 → Arg (1998) (22)
Human Tissue Factor Pathway Inhibitor Fused to CD4 Binds both FXa and TF/FVIIa at the Cell Surface (1997) (22)
Endogenous heparinoids contribute to coagulopathy in patients with liver disease. (2008) (21)
Factor VIII and haemophilia A. (1989) (21)
Inhibition of coagulation by macromolecular complexes. (2005) (21)
Gene therapy for haemophilia B (2012) (21)
Crystal structure of the extracellular region of human tissue factor (1994) (20)
α1-antitrypsin Pittsburgh in a family with bleeding tendency (2009) (20)
Factor VIIa and the extracellular domains of human tissue factor form a compact complex: A study by X‐ray and neutron solution scattering (1995) (20)
The varieties of von Willebrand's disease. (2008) (20)
Use of a non‐depleting anti‐CD4 antibody to modulate the immune response to coagulation factors VIII and IX (2002) (20)
Erratum: The hemophilias - From royal genes to gene therapy (New England Journal of Medicine (June 7, 2001) 344 (1773-9)) (2001) (20)
Postgraduate Haematology: Hoffbrand/Postgraduate Haematology (2010) (20)
Hyperviscosity Syndrome in IgA Multiple Myeloma (1974) (19)
Haemophilia A: carrier detection and prenatal diagnosis by linkage analysis using DNA polymorphism. (1987) (18)
Exclusion of the First EGF Domain of Factor VII by a Splice Site Mutation Causes Lethal Factor VII Deficiency (1998) (18)
A maximum likelihood estimate of the sex ratio of mutation rates in Haemophilia A (2004) (18)
Appendix II: World Health Organization Classification of Tumours of the Haematopoietic and Lymphoid Tissues (2010) (18)
A Single Intravenous Infusion of FLT180a Results in Factor IX Activity Levels of More Than 40% and Has the Potential to Provide a Functional Cure for Patients with Haemophilia B (2018) (17)
Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381 → Ser) in the substrate‐binding pocket (1993) (17)
Plasma volume expansion and increased serum viscosity in myeloma and macroglobulinaemia. (1974) (16)
Gene therapy for hemophilia? (2005) (15)
Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B. (2022) (14)
Identification of factor IX mutations in Iranian haemophilia B patients by SSCP and sequencing. (2007) (14)
Global coagulation assays in hemophilia A: A comparison to conventional assays (2019) (13)
The Interaction of Botrocetin with Normal or Variant von Willebrand Factor (Types IIA and IIB) and Its Inhibition by Monoclonal Antibodies that Block Receptor Binding (1992) (13)
Increase of activated factor VIIA and haemostatic molecular markers in juvenile chronic arthritis. (1995) (13)
An Alloantibody Recognizing the FVIII A1 Domain in a Patient with CRM Reduced Haemophilia A due to Deletion of a Large Portion of the A1 Domain DNA Sequence (2000) (13)
Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles. (1994) (12)
Identification of six functional clotting factor VIII:C epitopes by analysis of cross-reactive public idiotypes in murine monoclonal VIII:C inhibitors. (1987) (11)
Hyperviscosity syndrome in IgA multiple myeloma. (1973) (11)
Genetics of haemostasis (2012) (10)
Molecular genetics of familial venous thrombosis. (1994) (10)
Reactions to low-molecular-weight porcine factor VIII concentrates. (1981) (10)
Characterisation of blood coagulation factor XIT475I (2005) (10)
Monoclonal antibodies to human factor VII: a one step immunoradiometric assay for VII:Ag. (1988) (10)
Tissue Localization and Synthesis of Factor‐VIII‐Related Antigen in the Human Foetus (1974) (10)
Two novel mutations in severe factor VII deficiency (2003) (10)
AMINO ACID SUBSTITUTION AT THE EPIDERMAL GROWTH FACTOR 2-PROTEASE DOMAIN INTERFACE RESULTS IN SEVERELY REDUCED TISSUE FACTOR BINDING AND PROCOAGULANT FUNCTION* (1998) (10)
Factor VIII gene analysis in Japanese CRM‐positive and CRM‐reduced haemophilia A patients by single‐strand conformation polymorphism (1997) (10)
Disappearance of Antibodies to Factor VIII in a Patient with Acquired Haemophilia and Carcinoma of the Pancreas During Cytotoxic Therapy with Fluorouracil and CCNU (1984) (10)
Mutation databases on the Web. (1998) (9)
A Standard Nomenclature for Factor VIII and Factor IX Gene Mutations and Associated Amino Acid Alterations (1994) (9)
Interaction Between the a3 Region of Factor VIII and the TIL’E’ Domains of the von Willebrand Factor (2019) (9)
Activated protein C resistance in venous thrombosis (1994) (9)
10 Myeloproliferative and metabolic causes (1994) (9)
Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM−) and G1948D (CRMr) (2001) (9)
Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies (1987) (9)
Characterisation of lymphocyte responses to Ca2+ in Scott syndrome (2004) (9)
Corrigendum: The haemophilia A mutation search test and resource site, home page of the factor VIII mutation database: HAMSTeRS (Nucleic Acids Research (1996) 24 (100-102)) (1996) (8)
Gene therapy for the haemophilias. (1995) (8)
Immunologic studies of factor VIII coagulant activity (VIII:C). 2. Factor VIII in selected vertebrates. (1982) (8)
expression of human FIX in nonhuman primates of self-complementary AAV vector results in stable therapeutic Safe and efficient transduction of the liver after peripheral vein infusion (2013) (8)
Anticoagulation after liver transplantation: a retrospective audit and case–control study (2009) (8)
In search of the eighth factor: a personal reminiscence (2003) (8)
Inhibitors to Factor VIII—Molecular Basis (2007) (7)
Laboratory Evaluation of Hemostasis and Thrombosis: 3rd edn. (1984) (7)
Molecular Biological Aspects of Inhibitor Development (1999) (7)
The effect of an acute phase reaction and BCG innoculation on factor VIII in the guinea-pig. (1985) (7)
transduction of murine and nonhuman primate liver efficient liver-specific human factor IX expression cassette enable highly Self-complementary adeno-associated virus vectors containing a novel (2013) (7)
Inherited Bleeding Disorders (1985) (7)
Human Congenital Diseases with Mixed Modes of Inheritance Have a Shortage of Recessive Disease. A Demographic Scenario? (2011) (6)
Lipogranuloma of the breast due to phenothiazine therapy (1970) (6)
Thrombophilia: an expanding group of genetic defects that predispose to thrombosis. (1997) (6)
In search of the source of factor VIII. (2014) (6)
Genetic Basis of Inhibitor Development in Severe Haemophilia A and B (2008) (6)
Gene therapy for hemophilia? Gene therapy for hemophilia is both desirable and achievable in the near future. (2005) (5)
Hemophilia [4] (multiple letters) (2001) (5)
MOLECULAR CHARACTERIZATION OF THE FACTOR IX GENE IN 28 IRANIAN HEMOPHILIA B PATIENTS (2009) (5)
Haemophilia, the journey in search of a cure. 1960–2020 (2020) (5)
Response to desmopressin in type IID von Willebrand's disease. (1989) (5)
Bleeding score as a screening tool for the identification and assessment of von Willebrand disease in women (2007) (4)
Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition. (1994) (4)
Medicine: RNA as drug and antidote (2002) (4)
Purified factor VIII (1995) (4)
Ways to bypass a blocked tenase complex (2005) (4)
Monoclonal antibodies to human factor VII: production of immunodepleted plasma for VII:C assays. (1988) (4)
Axillary vein thrombosis in adolescent onset systemic sclerosis. (1990) (4)
Factor VIII: the protein, cloning its gene, synthetic factor and now – 35 years later – gene therapy; what happened in between? (2020) (4)
Killing 2 birds with 1 stone. (2008) (4)
concentrate in the treatment of hemophiliacs with antibodies to factor VIII Clinical experience with polyelectrolyte-fractionated porcine factor VIII (2011) (3)
The Synthesis of Factor V in Tissue Culture and Isolated Organ Perfusion (1975) (3)
Pre pregnancy thrombophilic abnormalities are associated with subsequent miscarriage (2000) (3)
Cellular Immune Responses To Vector In a Gene Therapy Trial For Hemophilia B Using An AAV8 Self-Complementary Factor IX Vector (2013) (3)
The tissue factor-factor VII complex: recent advances towards elucidating the structure and function of the initiator of haemostasis. (1996) (3)
Genetic aspects and research development in haemostasis (2008) (3)
Cloned factor VIII and the molecular genetics of hemophilia. (1986) (3)
Surgery with Turoctocog Alfa: Efficacy and Safety in Bleeding Prevention During Surgical Procedures - Results From the guardian™ Trials. (2012) (3)
Polyelectrolyte Fractionated Porcine Factor VIII Concentrate In The Treatment Of Haemophiliacs With Antibodies To Factor VIII: C (1981) (2)
O-132. Computerized thromboelastographic parameters amongst women with recurrent miscarriage—evidence for a pro-thrombotic state (1999) (2)
Junior Hospital Doctors' Contract (1975) (2)
Flipping the tip of the X (1993) (2)
A monoclonal antibody based immunoradiometric assay for von Willebrand factor: survey of a large patient group. (1987) (2)
Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B (2012) (2)
Factor-VIII Inhibitor in Less Severely Affected Haemophilic Patients (1975) (2)
From human to humans: Introducing the first recombinant human FVIII product produced from a human cell line (2010) (2)
Affinity Depletion and Affinity Purification of Human Factor IX by Monoclonal Antibodies (1983) (2)
Mono clonal antibodies to pro coagulant factor viii preparation and applications (1983) (2)
Erratum: Haemophilia A: Database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition (Nucleic Acids Research (1994) 22 (3511-3533)) (1994) (2)
Innovative alternatives to human factor VIII. (2009) (2)
Appendix 2: WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues (2005) (2)
Platelets are a safe way to deliver factor VIII. After 13 years of preclinical research it is now time for a clinical trial (2017) (2)
EXPRESSION OF NOVEL ANTICOAGULANT FUSION PROTEINS INHIBITS FACTOR XA‐ AND THROMBIN‐INDUCED ACTIVATION OF PORCINE VASCULAR ENDOTHELIAL CELLS.: Abstract# 1042 (2000) (2)
Assessing the Potential of Perinatal Gene Transfer Using Congenital Factor VII Deficiency as a Model System (2010) (2)
Haemophilic pseudotumour of the carotid artery (2012) (1)
Postpartum changes in the level of factor VIII and von Willebrand factor (2010) (1)
The Physiology of Hemostasis (1984) (1)
In Vitro Studies of Synthesis and Release of Factor VIII Related Protein by Endothelial Cells (1977) (1)
Genetic and Laboratory Diagnosis (2009) (1)
Subject Index, Vol. 26 (suppl 1), 1996 (1996) (1)
Gene therapy for severe hemophilia B (2012) (1)
Stable High Level Coagulation Factor VIII Expression In Vivo Following Gene Transfer Using a Novel Expression Cassette Encoding a More Potent FVIII Variant (2010) (1)
Molecular evolution of haemostasis. (2000) (1)
Mutations in the VKORC1 Gene Cause Warfarin Resistance, Warfarin Sensitivity and Combined Deficiency of Vitamin K Dependent Coagulation Factors. (2004) (1)
Factor VIII: purer is not necessarily better (2006) (1)
EXTRACELLULAR REGION OF HUMAN TISSUE FACTOR (1996) (1)
Myeloproliferative and metabolic causes. (1994) (1)
Appendix I: Normal Values (2010) (1)
LATE-BREAKING AND COVID-19 ORAL COMMUNICATION SESSION ABSTRACTS (2020) (1)
Hemophilia and Other Bleeding Disorders: Genetics (2006) (0)
The cellular site of synthesis of factor VIII in the circulation has long been disputed (2014) (0)
The road to cloning of factor VIII and the recombinant era (2015) (0)
A Cloned Dna Sequence Closely Linked to Haemophilia A (1984) (0)
Haemostasis and Thrombosis: Proceedings of the Serono Symposia, vol 15. (1980) (0)
COAGULATION ABNORMALITIES IN SEVERE STREPTOCOCCAL SHOCK SYNDROME: 74 (1999) (0)
The Use of a Pegylated Liposome in a Phase II Trial to Enhance the Potency and Extend the Dosing Interval of Prophylactic Standard Half-Life FVIII, without Increasing the Dose (2022) (0)
Prophylactic Treatment of Severe Haemophilia Á Patients with Inhibitors to FVIII with Peglip-FVIII (2021) (0)
Abstracts of Papers Presented at a Meeting of the British Society for Haematology held in London, 9 January 1976 (1976) (0)
THROMBOSIS AND HEMOSTASIS Solution structure of the major factor VIII binding region on von Willebrand factor (2014) (0)
THE 40-HOUR WEEK AND SHORTAGE SPECIALTIES (1975) (0)
either LMAN1 or MCFD2 Combined deficiency of factor V and factor VIII is due to mutations in (2013) (0)
ACTIVATED PROTEIN C RESISTANCE IN VENOUS THROMBOSIS. AUTHOR'S REPLY (1994) (0)
A23187 induced apoptosis and pro-coagulant activity are delayed, but not absent, in lymphocytes from an individual with Scott syndrome (2000) (0)
Is Factor VIII an Acute Phase Protein (1985) (0)
Hemophilia and hemostasis (progress in clinical and biological research vol. 72): edited by Doris Menache, Douglas MacN. Surgenor and Harlan Anderson, Alan R. Liss Inc, 1981. £20.50/DM 90.00 (xxiii + 282 pages) ISBN 0 8451 0072 9 (1982) (0)
Commentary on book review: A History of Blood Coagulation (2002) (0)
gene strategy for the detection of point mutations in the human factor VIII The molecular genetic analysis of hemophilia A : a directed search (2003) (0)
Book Review: The Physiology of Hemostasis (1984) (0)
Association of Thrombotic Disease with Genetic Polymorphism of Haemostatic Genes: Relevance to Pharmacogenetics (2004) (0)
Book Review: Hemophilia and Hemostasis (1982) (0)
Accumulation of Hypoactive Factor VIII in Liver Disease (1983) (0)
Accuracy of Point of Care Testing in Patients on Dual Anticoagulation During Initiation of Anticoagulation or Bridging (2011) (0)
Enhancing FVIII Expression By Modifying B-Domain Sequence for Hemophilia A Gene Therapy (2018) (0)
Factor VII and cardiovascular risk (2005) (0)
Human-Cl Rhfviii Effectively and Safely Prevents Bleeding Episodes in Previously Treated Adult Patients with Severe Haemophilia A (2012) (0)
Bone-marrow transplantation is not associated with increased levels of factor-VIIa [Abstract] (1993) (0)
Prothrombin Complex Concentrate for Warfarin Reversal: A Single Dose Is Effective for All INRs >4.5. (2008) (0)
Hemophilia and Hemostasis: Progress in Clinical and Biological Research, vol 72 (1982) (0)
Cardiovascular disease:hyperlipidaemia and coagulation:Editorial comment (1990) (0)
chromatography using a monoclonal antibody Preparation of factor IX deficient human plasma by immunoaffinity (2011) (0)
Thrombin Generation Is Normal in Most Patients with Cirrhosis despite a Prolonged INR. (2008) (0)
Thrombogenic mechanisms investigated with coagulation activation markers after infusion of factor IX concentrates in patients with haemophilia B (1995) (0)
Application of PCR to the detection and analysis of point mutations in the human factor VIII gene (1991) (0)
Book Review: Laboratory Evaluation of Hemostasis and Thrombosis (1984) (0)
Title Page / Table of Contents, Vol. 26, Supplement 1, 1996 (1996) (0)
Abstract (2003) (0)
variant administration of rAAV vector encoding a novel human factor VIII Therapeutic levels of FVIII following a single peripheral vein (2014) (0)
Genetically engineered and affinity purified plasma proteins. (1990) (0)
Use of Prothrombin Complex Concentrate (Beriplex/Octaplex) in Acquired Bleeding Disorders: A Two-Year Single Centre Experience. (2009) (0)
12 Genetically engineered and affinity purified plasma proteins (1990) (0)
Phenotypic classification of the mutations in coagulation factor IXx segregate to different locations in its protein structure (2012) (0)
mice by prenatal gene therapy Permanent phenotypic correction of Hemophilia B in immunocompetent (2013) (0)
Cardiovascular Pharmacogenetics (2004) (0)
Factor VIII Related Activities In Various Species (1981) (0)
Therapy genique s'appliquant a l'hemophilie (1994) (0)
Appendix 1: Normal Values (2005) (0)
P53 Menorrhagia in adolescents with inherited bleeding disorders (2009) (0)
Book Review: Integrated Clinical Science: Haematology (1984) (0)
Haemostatic, fibrinolytic and lipid parameters in relation to the initial manifestation of coronary artery disease (1996) (0)
Cardiovascular and Blood-Related Proteins (1988) (0)
Book Review: Haemostasis and Thrombosis (1980) (0)
aBNORMaL sPLIcING OF MUtaNt BRAF DRIV es R a F IN h IBI tOR R es I sta N ce (2012) (0)
Haemostatic problems in liver disease Table Principal coagulation abnormalities in liver disease I (0)
, the journey in search of a cure. (2022) (0)
Book Review: Platelet Transfusion (1980) (0)
Haemophilia: does the future lie in replacement therapy or auto-supply? (1998) (0)
The Molecular Genetic Analysis of Hemophilia A : A Directed Search Strategy for the Detection of Point Mutations in the Human Factor VI 11 Gene (2003) (0)
The Site of Synthesis of Factor VIII: C (1983) (0)
Inherited thrombophilias. (1997) (0)
On Historiography of Eugenics by Jonathan Marks. (1993) (0)
Far away and long ago (2014) (0)
Proceedings: Factor-VIII-related antigen in the human foetus and its synthesis in tissue culture. (1974) (0)
associated with thrombosis Functional characterization of factor V-Ile359Thr: a novel mutation (2013) (0)
Untitled (2017) (0)
Sterilise in haste, repent at leisure and great expense (2000) (0)
TheLocusforCombinedFactor V-Factor VilDeficiency (F5F8D) Mapsto18q21, between D18S849andD18S1103 (1997) (0)
“Magic” mushrooms don’t cause renal failure (2012) (0)

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