Edwin Southern
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English molecular biologist
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Edwin Southernbiology Degrees
Biology
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#170
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Molecular Biology
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#17
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Genetics
#42
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#67
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Biology
Why Is Edwin Southern Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sir Edwin Mellor Southern is an English Lasker Award-winning molecular biologist, Emeritus Professor of Biochemistry at the University of Oxford and a fellow of Trinity College, Oxford. He is most widely known for the invention of the Southern blot, published in 1975 and now a common laboratory procedure.
Edwin Southern's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Detection of specific sequences among DNA fragments separated by gel electrophoresis. (1975) (29251)
- Molecular interactions on microarrays (1999) (767)
- Gel electrophoresis of restriction fragments. (1979) (551)
- Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays. (1997) (391)
- Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. (1978) (388)
- Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models. (1992) (368)
- Measurement of DNA length by gel electrophoresis. (1979) (364)
- Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ. (1992) (324)
- Long range periodicities in mouse satellite DNA. (1975) (314)
- Base Sequence and Evolution of Guinea-pig α-Satellite DNA (1970) (309)
- Removal of repeated sequences from hybridisation probes. (1985) (265)
- Selecting effective antisense reagents on combinatorial oligonucleotide arrays (1997) (261)
- A model for the separation of large DNA molecules by crossed field gel electrophoresis. (1987) (251)
- The Efficacy of Small Interfering RNAs Targeted to the Type 1 Insulin-like Growth Factor Receptor (IGF1R) Is Influenced by Secondary Structure in the IGF1R Transcript* (2003) (248)
- Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids. (1994) (222)
- DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale. (1996) (189)
- Determining the influence of structure on hybridization using oligonucleotide arrays (1999) (185)
- Different sequences for 5S RNA in kidney cells and ovaries of Xenopus laevis. (1973) (152)
- Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes. (1997) (117)
- Heterogeneity of the ribosomal genes in mice and men (1977) (116)
- DNA microarrays. History and overview. (2001) (115)
- Oligonucleotide dendrimers: stable nano-structures. (1999) (105)
- Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation. (1992) (104)
- Selecting optimal antisense reagents. (2000) (101)
- A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. (1993) (98)
- Measurement of DNA length by gel electrophoresis II: Comparison of methods for relating mobility to fragment length. (1983) (92)
- In Vitro Evidence That the Untranslated Leader of the HIV-1 Genome Is an RNA Checkpoint That Regulates Multiple Functions through Conformational Changes* (2002) (92)
- A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. (2004) (84)
- Ellipsometric and Interferometric Characterization of DNA Probes Immobilized on a Combinatorial Array (1997) (81)
- Southern blotting (2020) (80)
- Studies on the base pairing properties of deoxyinosine by solid phase hybridisation to oligonucleotides. (1994) (74)
- An improved method for transferring nucleotides from electrophoresis strips to thin layers of ion-exchange cellulose. (1974) (70)
- Fetal anoxia and its possible relation to changes in the prenatal fetal electrocardiogram. (1957) (69)
- A simple and cost-effective method for producing small interfering RNAs with high efficacy. (2003) (69)
- Multiplex target protein imaging in tissue sections by mass spectrometry--TAMSIM. (2007) (68)
- Partial sequence analysis of mouse satellite DNA evidence for short range periodicities. (1975) (67)
- Electrochemically directed synthesis of oligonucleotides for DNA microarray fabrication (2005) (66)
- Chromatography of nucleic acid digests on thin layers of cellulose impregnated with polyethyleneimine. (1971) (65)
- The folding of large RNAs studied by hybridization to arrays of complementary oligonucleotides. (1999) (63)
- Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. (2001) (63)
- In situ oligonucleotide synthesis on poly(dimethylsiloxane): a flexible substrate for microarray fabrication (2005) (62)
- Effects of sequence divergence on the reassociation properties of repetitive DNAs. (1971) (60)
- Sequence variation in genes and genomic DNA: methods for large-scale analysis. (2000) (58)
- Enhanced recovery and restriction mapping of DNA fragments cloned in a new λ vector (1988) (58)
- Effects of base mismatches on joining of short oligodeoxynucleotides by DNA ligases. (1997) (56)
- Automatic reading of DNA sequencing gel autoradiographs using a large format digital scanner (1986) (51)
- A novel method for the analysis of multiple sequence variants by hybridisation to oligonucleotides. (1993) (50)
- Fidelity of DNA ligation: a novel experimental approach based on the polymerisation of libraries of oligonucleotides. (1998) (50)
- Detection of specific sequences among DNA fragments separated by gel electrophoresis. 1975. (1992) (49)
- Application of DNA analysis to mapping the human genome. (1982) (46)
- Minimising the secondary structure of DNA targets by incorporation of a modified deoxynucleoside: implications for nucleic acid analysis by hybridisation. (2000) (41)
- How to find all those mutations (1995) (40)
- Analysing genetic information with DNA arrays. (1998) (39)
- Probing alternative foldings of the HIV-1 leader RNA by antisense oligonucleotide scanning arrays. (2004) (39)
- Studies of oligonucleotide interactions by hybridisation to arrays: the influence of dangling ends on duplex yield. (1994) (39)
- A novel method for the parallel analysis of multiple mutations in multiple samples. (1993) (37)
- Blotting at 25. (2000) (36)
- Report on the sequencing by hybridization workshop. (1992) (35)
- Pulsed‐field Gel Electrophoresis of DNA (2003) (34)
- Trityl Tags for Encoding in Combinatorial Synthesis (2000) (30)
- ELECTROCARDIOGRAPHY AND PHONOCARDIOGRAPHY OF THE FOETAL HEART (1954) (28)
- Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with scanning array-designed antisense oligonucleotides. (2003) (28)
- Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays. (1997) (26)
- The prostaglandins: clinical applications in human reproduction (1972) (25)
- Measurement of DNA length by gel electrophoresis. I. Improved accuracy of mobility measurements using a digital microdensitometer and computer processing. (1983) (24)
- 5 – Gel Electrophoresis of Restriction Fragments (1989) (24)
- Hybridization of antisense reagents to RNA. (2000) (24)
- Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides. (1994) (22)
- Trityl mass-tags for encoding in combinatorial oligonucleotide synthesis. (1999) (21)
- An electrochemical redox couple activitated by microelectrodes for confined chemical patterning of surfaces. (2002) (21)
- Ultraviolet irradiation of DNA: a way of generating partial digests for rapid restriction site mapping. (1986) (20)
- Clones from an 840-kb fragment containing the 5' region of the DMD locus enriched by pulsed field gel electrophoresis. (1988) (16)
- A preparative gel electrophoresis apparatus for large scale separations. (1979) (16)
- Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications. (2008) (16)
- The genesis of microarrays (2014) (15)
- Novel mass tags for single nucleotide polymorphism detection. (2008) (15)
- Base sequence and evolution of guinea-pig alpha-satellite DNA. (1970) (15)
- Using oligonucleotide scanning arrays to find effective antisense reagents. (2001) (14)
- The action of a restriction endonuclease on higher organism DNA. (1974) (13)
- High-density gridding: techniques and applications. (1996) (12)
- Enhanced recovery and restriction mapping of DNA fragments cloned in a new lambda vector. (1988) (12)
- Optimised ligation of oligonucleotides by thermal ligases: comparison of Thermus scotoductus and Rhodothermus marinus DNA ligases to other thermophilic ligases. (2000) (12)
- Genome mapping: cDNA approaches. (1992) (12)
- DNA Sequences and Chromosome Structure (1984) (11)
- Tools for genomics (2005) (10)
- S(O)-pixyl protecting group as efficient mass-tag. (2005) (10)
- Changing trends in caesarean section. (1958) (10)
- Fluorescence in situ hybridisation of multiple probes on a single microscope slide. (1994) (9)
- Thermus scotoductus and Rhodothermus marinus DNA ligases have higher ligation efficiencies than thermus thermophilus DNA ligase. (2002) (8)
- Oligonucleotide scanning arrays: application to high-throughput screening for effective antisense reagents and the study of nucleic acid interactions. (2002) (8)
- Conformations of satellite DNAs. (1976) (8)
- Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels (2000) (8)
- Analysis of a study of menses induction using a vaginal suppository containing 3.0 mg 15(S)-15-methyl-PGF2 alpha methyl ester. (1980) (8)
- Analysis of restriction-fragment patterns from complex deoxyribonucleic acid species. (1979) (7)
- The early days of blotting. (2015) (6)
- Prospects for a complete molecular map of the human genome. (1988) (5)
- Antisense arrays. (2000) (5)
- Fred Sanger - Double Nobel Laureate: A Biography (2014) (5)
- New methods for analysing DNA make genetics simpler. (1982) (5)
- A modelfortheseparation oflarge DNAmolecules bycrossed field gelelectrophoresis (1987) (5)
- Aberrant Endometrial Tissue and Intussusception (1948) (4)
- RADIATION CHEMISTRY OF POLYAMINO ACIDS IN AQUEOUS SOLUTIONS. (1968) (4)
- The effect of a 15(S)-15-methyl prostaglandin F2 alpha (methyl ester) suppository upon termination of early pregnancy. (1980) (4)
- Synthesis of S-Pixyl Derivatives for Mass Spectrometric Applications (2005) (4)
- Denaturing Gel Electrophoresis of RNA and DNA Using Urea–Polyacrylamide Gels (2002) (3)
- Clinical comparison of abortifacient activity of vaginally administered prostaglandin E2 in two dosage forms. (1977) (3)
- Structural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy (2005) (3)
- An evaluation of contractile activity in the lower uterine segment in labor by external tokodynamometry. (1957) (3)
- Antisense Oligonucleotide Scanning Arrays (2001) (3)
- Radiation-induced hydrogen isotope exchange in solutions of polyamino acids. (1969) (2)
- Analysing DNA in small numbers of cells. (1987) (2)
- Synthesis of S-Pixyl Derivatives for Mass Spectrometric Applications. (2006) (2)
- IRRADIATION OF MEAT PROTEIN. (1967) (1)
- THE SYNTHESIS OF BRANCHED OLIGONUCLEOTIDE STRUCTURES (1998) (1)
- Oligonucleotide arrays for genotyping: enzymatic methods for typing single nucleotide polymorphisms and short tandem repeats. (2003) (1)
- Preliminary trials of vaginal silastic devices containing (15s)-15 methyl prostaglandin f2 alpha methyl ester for the induction of menses and for pregnancy termination summary of brook lodge workshop (January 29, 1976). (1976) (1)
- A case of foetus papyraceus. (1956) (1)
- Denaturing Gel Electrophoresis of DNA in Alkaline Agarose Gels (2002) (1)
- Electrophoresis of DNA and RNA in Non‐denaturing Vertical Polyacrylamide Gels (2003) (1)
- Analyse de sequences de polynucleotides (1989) (1)
- Management of Intrauterine Fetal Demise and Missed Abortion Using Prostaglandin E2 Vaginal Suppositories (1976) (1)
- The termination of human pregnancy with prostaglandin analogs. (1975) (1)
- Electroblotting of Gels (2003) (0)
- Etikettierreagenz and proven method (1994) (0)
- S(O)‐Pixyl Protecting Group as Efficient Mass‐Tag. (2005) (0)
- DNA microarrays - the how and the why. (1999) (0)
- Problem solved: an interview with Sir Edwin Southern. Interviewed by Jane Gitschier. (2013) (0)
- Isolation of DNA from Agarose Gels using Agarase (2003) (0)
- Cancer: the impact of new-generation sequencing (2014) (0)
- The industrial challenge in reproductive drug development. (1978) (0)
- Isolation of DNA from Low Gelling Temperature Agarose (2003) (0)
- A method for the highly parallel analysis of gene expression of single cells (2007) (0)
- DNA Variation and Its Analysis by Hybridisation to Oligonucleotide Arrays (1994) (0)
- Substrate-bound oligonucleotides. (1989) (0)
- Preis Molecular Bioanalytics 2004 (2004) (0)
- Prostaglandins and their clinical applications in human reproduction. (1972) (0)
- Application of DNA analysis to mapping the human genome. (1982) (0)
- PRESENT STATUS AND FUTURE PROSPECTS OF FOOD IRRADIATION. (1967) (0)
- Alkaline Blotting of DNA Gels (2003) (0)
- Interview of Fred by the author in 1992: Early life (2014) (0)
- Etiketierreagenz and detection method (1994) (0)
- Mapping the human genome by analysing the DNA (1981) (0)
- Devices and methods for the analysis of individual cells (2006) (0)
- DNA microarrays—the how and the why (abstract) (1999) (0)
- Foetus Papyraceus (1956) (0)
- Electrocardiographic interpretations in late prenatal and early neonatal life. (1962) (0)
- Interview of Fred by the author in 1992: Nucleic acids at the MRC Laboratory of Molecular Biology, Cambridge (2014) (0)
- Radiation-induced optical inversion of L-glutamate residues in poly-alpha,L-glutamic acid. (1965) (0)
- Labeling reagent and assay method. (1994) (0)
- Method for the Concentration of RNA and DNA Samples (2002) (0)
- High Resolution Electrochemical In Situ Printing (2004) (0)
- Structural features of the Y chromosome (1987) (0)
- Fred Sanger - Double Nobel Laureate: Interview of Fred by the author in 1992: Insulin and the Biochemistry Department, University of Cambridge (2014) (0)
- The use of prostaglandins for the therapeutic termination of pregnancy. (1974) (0)
- Sports in the Carolinas: From Death Valley to Tobacco Road (2009) (0)
- Restriction Enzyme Digests of DNA in Agarose Plugs for Pulsed Field Gel Electrophoresis (2003) (0)
- THE EFFECT 0~ A ~~(S)-~~-METH~L PROSTAGLANDIN F (METHYL ESTER) (1980) (0)
- Detection of nucleic acid changes (1996) (0)
- Libraries of oligomers with different tags (TAGS) are marked (1999) (0)
- cDNA approaches to genome mapping (1992) (0)
- Staining, Viewing and Photography of Gels and Estimation of Fragment Sizes (2003) (0)
- Chromatography ofNucleic AcidDigests on ThinLayersofCellulose Impregnated withPolyethyleneimine (1971) (0)
- The Prevention and avoidance of genetic disease : proceedings of a Royal Society discussion meeting held on 29 and 30 april 1987 (1988) (0)
- A Quaker upbringing (2014) (0)
- Minimizing the secondary structure of DNA targets with a modified deoxynucleoside and its implication for nucleic acid analysis by hybridization (1999) (0)
- Library of oligomers that are labeled with various markers (1999) (0)
- Fred Sanger - Double Nobel Laureate: Radioactive sequencing of proteins and nucleic acids (2014) (0)
- Combined Strassmann Metroplasty and Bilateral Tuboplasty: Report of a Case Resulting in Normal Pregnancy (1961) (0)
- A new device for pre-operation cervical dilatation. (1980) (0)
- Denaturing Formamide Polyacrylamide Gels for Separating RNA and DNA (2003) (0)
- Calibration of a Transilluminator for UV Fixation of DNA to Nylon Filters (2003) (0)
- Post-Sanger sequencing: high-throughput automated sequencing (2014) (0)
- A simple and cost-effective method for producing small interfering RNAs with high ef®cacy (0)
- Fighting Climate Stress with Orphan Legumes (2016) (0)
- A method and apparatus for generating biopolymermatrizen on a solid phase support surface (1994) (0)
- Separation of RNA and DNA in Methylmercuric Hydroxide Denaturing Agarose Gels (2003) (0)
- Oligonucleotides lies a un support (1989) (0)
- Letter from Ed Southern, Medical Research Council of Great Britain to Harold Varmus and Stephen Hughes (1978) (0)
- Confocal image following hybridization indicating non-uniform synthesis of 6mer oligonucleotides (5′-CTACGC) on HBAPTES deposited via solution-phase silanization (2011) (0)
- Appendix: Complete bibliography of Fred Sanger (2014) (0)
- The tag and method of analysis (1996) (0)
- Denaturation of RNA Using Glyoxal (2003) (0)
- Commentaries on Fred Sanger’s scientific legacy (2014) (0)
- Fred Sanger - Double Nobel Laureate: Honours (2014) (0)
- Libraries of differentially labeled oligomeric (1999) (0)
- Gel Electrophoresis of RNA in Denaturing Formaldehyde Agarose Gels (2003) (0)
- Labeling reagent and analytical approach. (1994) (0)
- Capillary Blotting of RNA and DNA Gels (2003) (0)
- Some aspects of intrauterine fetal anoxia. (1957) (0)
- Microarrays for basic studies of nucleic acid hybridization and selection of antisense reagents (1999) (0)
- Fred Sanger - Double Nobel Laureate: How about studying insulin? (2014) (0)
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