Elaine Sanders‐bush
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Elaine Sanders‐bush's Degrees
- PhD Pharmacology Vanderbilt University
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(Suggest an Edit or Addition)Elaine Sanders‐bush's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Regulation of serotonin-2C receptor G-protein coupling by RNA editing (1997) (1001)
- National Institutes of Health State-of-the-Science Conference Statement: Preventing Alzheimer Disease* and Cognitive Decline (2010) (416)
- RNA Editing of the Human Serotonin 5-Hydroxytryptamine 2C Receptor Silences Constitutive Activity* (1999) (366)
- Serotonin and brain development. (2004) (301)
- Structural Instability of a Constitutively Active G Protein-coupled Receptor (1997) (280)
- Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior (2012) (273)
- A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. (1986) (266)
- Surface modification to reduce nonspecific binding of quantum dots in live cell assays. (2005) (252)
- RNA Editing of the Human Serotonin 5-HT2C Receptor: Alterations in Suicide and Implications for Serotonergic Pharmacotherapy (2001) (252)
- Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. (1994) (251)
- Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. (1987) (225)
- Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. (1985) (204)
- Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms. (1975) (202)
- Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site (1986) (194)
- Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex (2003) (194)
- Serotonin receptor sensitivity after acute and chronic treatment with mianserin. (1982) (192)
- Selective 5ht-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex (1984) (171)
- NIH state-of-the-science conference statement: Preventing Alzheimer's disease and cognitive decline. (2010) (157)
- Long-term effects of p-chloroamphetamine on tryptophan hydroxylase activity and on the levels of 5-hydroxytryptamine and 5-hydroxyindole acetic acid in brain. (1972) (157)
- A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis (2007) (154)
- Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. (1988) (153)
- Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo (1999) (146)
- RNA‐editing of the 5‐HT2C receptor alters agonist‐receptor‐effector coupling specificity (2001) (145)
- Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A (2009) (138)
- Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. (1996) (135)
- Polymorphisms in the Regulatory Region of the Human Serotonin 5-HT2A Receptor Gene (HTR2A) Influence Gene Expression (2007) (130)
- Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (125)
- Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors (1998) (122)
- A Single Dose of Lysergic Acid Diethylamide Influences Gene Expression Patterns within the Mammalian Brain (2002) (120)
- IMMEDIATE AND LONG‐TERM EFFECTS OF p‐CHLOROAMPHETAMINE ON BRAIN AMINES * (1978) (114)
- Metabotropic Glutamate Receptor 5-Induced Phosphorylation of Extracellular Signal-Regulated Kinase in Astrocytes Depends on Transactivation of the Epidermal Growth Factor Receptor (2001) (105)
- Multiple serotonin receptors: regional distribution and effect of Raphe lesions. (1981) (104)
- The Serotonin Receptors (1989) (99)
- Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3',5'-monophosphate. (1989) (99)
- Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice. (1980) (97)
- Reciprocal binding properties of 5-hydroxytryptamine type 2C receptor agonists and inverse agonists. (1994) (96)
- Biogenic amines and narcotic effects. II. Serotonin turnover in the rat after acute and chronic morphine administration. (1973) (95)
- Dissecting G Protein-coupled Receptor Signaling Pathways with Membrane-permeable Blocking Peptides (2000) (94)
- Identification and Characterization of RNA Editing Events within the 5‐HT2C Receptor a (1998) (92)
- 5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat (1999) (91)
- Effect of drugs on amines in the CNS. (1971) (86)
- Putative selective 5-HT-2 antagonists block serotonin 5-HT-1c receptors in the choroid plexus. (1988) (85)
- p-Chloroamphetamine--inhibition of cerebral tryptophan hydroxylase. (1972) (78)
- Long-term effects of fenfluramine on central serotonergic mechanisms (1979) (78)
- Increased basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization. (1995) (78)
- 5-HT2C receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice (2006) (78)
- The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen (2010) (76)
- Agonist‐Induced Phosphoinositide Hydrolysis in Choroid Plexus (1986) (76)
- Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives. (1997) (75)
- 5-Hydroxytryptamine2C Receptor Contribution to m-Chlorophenylpiperazine and N-Methyl-β-carboline-3-carboxamide-Induced Anxiety-Like Behavior and Limbic Brain Activation (2007) (74)
- Serotonin 5-ht2 receptors: molecular and genomic diversity. (2003) (74)
- The serotonin autoreceptor: Antagonism by quipazine (1982) (73)
- His452Tyr polymorphism in the human 5-HT2A receptor destabilizes the signaling conformation. (2004) (73)
- Phospholipase D Activation by Endogenous 5-Hydroxytryptamine 2C Receptors Is Mediated by Gα13 and Pertussis Toxin-Insensitive Gβγ Subunits (2002) (70)
- 5-hydroxytryptamine1C receptor density and mRNA levels in choroid plexus epithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. (1993) (69)
- (+)Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist. (1991) (66)
- p-Chloroamphetamine. Temporal relationship between psychomotor stimulation and metabolism of brain norepinephrine. (1970) (65)
- Agonist-induced Phosphorylation of the Serotonin 5-HT2C Receptor Regulates Its Interaction with Multiple PDZ Protein 1* (2003) (65)
- Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release (1982) (64)
- Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis. (1990) (63)
- Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration. (2003) (63)
- Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression (2008) (62)
- Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor. (1995) (62)
- P-chloroamphetamine: in vivo investigations on the mechanism of action of the selective depletion of cerebral serotonin. (1970) (62)
- Agonist-Directed Signaling of Serotonin 5-HT2C Receptors: Differences Between Serotonin and Lysergic Acid Diethylamide (LSD) (1999) (61)
- Signal transduction abnormalities in melancholic depression. (2005) (61)
- Distribution of serotonin 5‐HT2A receptors in afferents of the rat striatum (2001) (61)
- On the mechanism of brain 5-hydroxytryptamine depletion by p-chloroamphetamine and related drugs and the specificity of their action. (1974) (59)
- Serotonergic Antagonist Effects on Trafficking of Serotonin 5‐HT2A Receptors in Vitro and in Vivo a (1998) (59)
- Tryptophan hydroxylase activity in developing rat brain 1 (1971) (59)
- Discriminative stimulus properties of quipazine: mediation by serotonin2 binding sites. (1984) (58)
- RNA editing of the human serotonin 5-HT(2C) receptor delays agonist-stimulated calcium release. (2000) (55)
- Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor (1999) (54)
- Increased serotonin turnover in the acutely morphine treated rat. (1971) (54)
- Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors (2002) (53)
- Sodium‐Dependent Antiporters in Choroid Plexus Epithelial Cultures from Rabbit (1993) (53)
- Behavioral Tolerance to Lysergic Acid Diethylamide is Associated with Reduced Serotonin-2A Receptor Signaling in Rat Cortex (2005) (52)
- Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase‐1, C/EBP‐β and ILAD‐1, a novel gene with homology to arrestins (2004) (51)
- Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus (1987) (50)
- Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists (1986) (50)
- RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA. (2004) (49)
- Role of Gq protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (2007) (48)
- Sertraline-induced desensitization of the serotonin 5HT-2 receptor transmembrane signaling system (2004) (45)
- Differences in agonist-independent activity of 5-HT2A and 5-HT2C receptors revealed by heterologous expression (1999) (44)
- Decreased Serotonin 5-HT2A Receptor-Stimulated Phosphoinositide Signaling in Fibroblasts from Melancholic Depressed Patients (2004) (44)
- National Institutes of Health State-ofthe-Science Conference Statement : Preventing Alzheimer Disease * and Cognitive Decline (2010) (43)
- Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms (2005) (43)
- Discriminative stimulus properties of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(±)DOI] in C57BL/6J mice (2003) (43)
- Hallucinogens and Drosophila: linking serotonin receptor activation to behavior (2002) (40)
- A Rapid New Assay to Detect RNA Editing Reveals Antipsychotic-Induced Changes in Serotonin-2C Transcripts (2005) (40)
- Actions of drugs that deplete serotonin. (1977) (40)
- Central serotonin receptors: effector systems, physiological roles and regulation (2004) (39)
- Regulation of Serotonin2A Receptors in Heterologous Expression Systems (1994) (39)
- m-chlorophenylpiperazine and m-trifluoromethylphenylpiperazine are partial agonists at cloned 5-HT2A receptors expressed in fibroblasts. (1994) (38)
- p-Chloramphetamine--species differences in the rate of disappearance and the lowering of cerebral serotonin. (1971) (38)
- Biochemical characterization of serotonin stimulated phosphoinositide turnover. (1986) (38)
- The serotonin/norepinephrine-link in brain. II. Role of serotonin in the regulation of beta adrenoceptors in the low agonist affinity conformation. (1988) (37)
- 5HT2 binding sites after mianserin: comparison of loss of sites and brain levels of drug. (1987) (35)
- Serotonin1c receptor reserve in choroid plexus masks receptor subsensitivity. (1990) (35)
- Identification of rat serotonin 5-HT2C receptors as glycoproteins containing N-linked oligosaccharides. (1995) (35)
- Species differences in the rate of disappearance of fenfluramine and its effects on brain serotonin neurons. (1979) (35)
- Effector systems coupled to serotonin receptors in brain: serotonin stimulated phosphoinositide hydrolysis. (1986) (34)
- Phospholipase D activation by endogenous 5-hydroxytryptamine 2C receptors is mediated by Galpha13 and pertussis toxin-insensitive Gbetagamma subunits. (2002) (34)
- Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice (2005) (33)
- Adaptation of brain 5HT2 receptors after mianserin treatment: receptor sensitivity, not receptor binding, more accurately correlates with behavior. (1990) (33)
- 5-Hydroxytryptamine (Serotonin)2A Receptors in Rat Anterior Cingulate Cortex Mediate the Discriminative Stimulus Properties of d-Lysergic Acid Diethylamide (2007) (32)
- Generation of anti-peptide antibodies against serotonin 5-HT2A and 5-HT2C receptors (1997) (32)
- Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium (1992) (32)
- Behavioral effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI) in the elevated plus-maze test. (1995) (30)
- Correlation between brain levels and biochemical effects of the optical isomers of p-chloroamphetamine. (1975) (30)
- Impact of RNA Editing on Functions of the Serotonin 2C Receptor in vivo (2009) (30)
- Choroid plexus epithelial cells in primary culture: a model of 5HT1C receptor activation by hallucinoginic drugs (2005) (29)
- Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling (1998) (27)
- Evaluation of the neurotoxic effects of p-chloroamphetamine: A histological and biochemical study (1978) (26)
- Preventing Alzheimer Disease and Cognitive Decline (2011) (26)
- Acute tissue-type plasminogen activator release in human microvascular endothelial cells: The roles of Gαq, PLC-β, IP3 and 5,6-epoxyeicosatrienoic acid (2007) (25)
- Hallucinogens and serotonergic mechanisms. (1992) (25)
- Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. (1995) (24)
- Metabolism of bufotenine-2'-14C in human volunteers. (1976) (24)
- Differences in agonist-independent and -dependent 5-hydroxytryptamine2C receptor-mediated cell division. (1996) (23)
- Clozapine blocks disruptive and discriminative stimulus effects of quipazine. (1984) (22)
- 5-HT Receptors Coupled to Phosphoinositide Hydrolysis (1988) (22)
- Serotonin Receptor Signaling and Hallucinogenic Drug Action (2004) (21)
- Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites (1983) (21)
- An innovative real-time PCR method to measure changes in RNA editing of the serotonin 2C receptor (5-HT2CR) in brain (2009) (21)
- Long-term reduction of brain serotonin by p-chloroamphetamine: effects of inducers and inhibitors of drug metabolism. (1978) (20)
- Chronic Phenethylamine Hallucinogen Treatment Alters Behavioral Sensitivity to a Metabotropic Glutamate 2/3 Receptor Agonist (2008) (20)
- Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. (2007) (18)
- Developmental switch in the hippocampal serotonin receptor linked to phosphoinositide hydrolysis (1995) (18)
- Unsurmountable antagonism of brain 5-hydroxytryptamine2 receptors by (+)-lysergic acid diethylamide and bromo-lysergic acid diethylamide. (1992) (17)
- From neurotransmitter to gene: identifying the missing links. (1991) (16)
- The serotonin-norepinephrine link hypothesis of affective disorders: receptor-receptor interactions in brain. (1987) (16)
- Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice (2014) (16)
- 5-Hydroxytryptamine type 2A and 2C receptors linked to Na+/K+/Cl- cotransport. (1994) (16)
- Universal polyethylene glycol linkers for attaching receptor ligands to quantum dots. (2006) (15)
- Regulation of serotonin storage and release. (1982) (15)
- Tyr Polymorphism in the Human 5-HT 2 A Receptor Destabilizes the Signaling Conformation (2004) (15)
- Temporal effects of p-chloroamphetamine on catecholamine synthesis. (1977) (14)
- An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine (1975) (14)
- Synaptosomal uptake and levels of serotonin in rat brain areas after p-chloroamphetamine or B-9 lesions. (1975) (13)
- Action of (S)-and(R)-para-substituted amphetamine hydrochlorides and (alphaS)-and (alphaR)-p-chloronorephedrine and (alphaS)-and (alphaR)-p-chloronorpseudoephedrine hydrochlorides on the level of 5-hydroxytryptamine and the activity of tryptophan hydroxylase in rat brain. (1974) (13)
- Neurochemical evidence that hallucinogenic drugs are 5-HT1c receptor agonists: what next? (1994) (13)
- Long-term effects of continuous exposure to p-chloroamphetamine on central serotonergic mechanisms in mice. (1978) (12)
- Dissecting Intracellular Signaling Pathways with Membrane-Permeable Peptides (2000) (12)
- 5-HT-induced transferrin production by choroid plexus epithelial cells in culture: role of 5-HT1c receptor. (1990) (11)
- Discriminative stimulus properties of l-5-hydroxytryptophan: Behavioral evidence for multiple serotonin receptors (2004) (11)
- Reversible and irreversible effects of p-chloroamphetamine on brain serotonin in mice. (1977) (10)
- The serotonin/noradrenaline-link in brain (1987) (10)
- Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. (1998) (10)
- Facilitation of sidman avoidance performance by p-chloroamphet amine: Role of biogenic amines (1977) (10)
- Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus (1991) (10)
- p-Chloroamphetamine: evidence against a serotonin mediated learning deficit in PKU. (1974) (9)
- Serotonin Receptor Signaling (2004) (9)
- Halogen substitution of amphetamine biochemical and pharmacological consequences (1974) (9)
- The serotonin/norepinephrine-linked beta-adrenoceptor system and the mode of action of antidepressants. (1985) (8)
- Quantitative trait loci mapping and gene network analysis implicate protocadherin‐15 as a determinant of brain serotonin transporter expression (2014) (8)
- Stimulus generalization by fenfluramine in a quipazine–ketanserin drug discrimination is not dependent on indirect serotonin release (2002) (8)
- Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following δ9-tetrahydrocannabinol (2004) (8)
- Additional evidence that l-5-hydroxytryptophan discrimination models a unique serotonin receptor (2004) (7)
- Tolerance to p-chloroamphetamine's effects on sidman avoidance performance and catecholamine metabolism (1977) (6)
- RNA editing of the serotonin 2C receptor and expression of Gαq protein: genetic mouse models do not support a role for regulation or compensation (2009) (6)
- Diazomethane: improved analytical and distillation techniques for small quantities and some synthetic applications. (1980) (5)
- Serotonin/Norepinephrine Receptor Interactions: Sensitivity Changes after Antidepressants and Lesions (1987) (4)
- Long-term effects of para-chloroamphetamine on central serotonergic mechanisms. (1976) (4)
- Serotonin Receptors and Neurotransmission (2004) (3)
- RECENT STUDIES ON THE MECHANISM OF ACTION OF CHLORINATED AMPHETAMINES (1973) (3)
- Pharmacology, Function and Adaptive Regulation of 5HT-1c Receptors (1990) (2)
- Rapid tolerance to the motor effects of p-chloroamphetamine in rats (1977) (2)
- Modification of the noradrenergic cyclic AMP generating system in the rat limbic forebrain by amphetamine: Role of its hydroxylated metabolites (1979) (2)
- Unique serotonin receptor (5HT-1C) in choroid plexus is linked to phosphoinositide hydrolysis (1986) (2)
- Constitutively Active 5-Hydroxytryptamine2, (1994) (2)
- The molecular mechanisms of calcium dependent tissue-type plasminogen activator release (2003) (1)
- Specificity of 5‐HT2A Receptor Ligands in Mice (2008) (1)
- ACTION OF (S)- AND (R)-PARA-SUBSTITUTED AMPHETAMINE HYDROCHLORIDES AND (S)- AND (R)-P-CHLORONOREPHEDRINE AND (S)- AND (R)-P-CHLORONORPSEUDOEPHEDRINE HYDROCHLORIDES ON THE LEVEL OF 5-HYDROXYTRYPTAMINE AND THE ACTIVITY OF TRYPTOPHAN HYD (1974) (1)
- Schild analyses reveal that the cerebral cortical serotonin 5HT/sub 2/ site is linked to phosphoinositide (PI) hydrolysis: relative efficacies of piperazines (1986) (1)
- Phospholipase D Activation by Endogenous 5-Hydroxytryptamine 2C Receptors Is Mediated by G (cid:1) 13 and Pertussis Toxin-Insensitive G (cid:2)(cid:3) Subunits (2002) (0)
- Ex vivo and in vivo changes in function of the serotonin 2C receptor due to RNA editing (2009) (0)
- The Role of Noradrenergic and Serotonergic Neuronal Input in the Regulation of Density and Function of Central Noradrenergic Receptor Systems (1987) (0)
- Centennial perspective: serotonin receptors. (2008) (0)
- No relationship found between RNA editing of the serotonin 2c receptor and expression of Gαq protein (2008) (0)
- CONTROL OF INTRACELLULAR SIGNALING PATHWAYS: LESSONS FROM THE SEROTONIN 5-HT2C RECEPTOR (1999) (0)
- Serotonin/Norepinephrine/Steroid Receptor Link in Brain and the Mode of Action of Antidepressants: Update and New Perspectives (1989) (0)
- Editorial commentary (1995) (0)
- Halogen substitution of amphetamine-like drugs: Biochemical and pharmacological consequences (1973) (0)
- Na+/H+ antiport in cultured choroid plexus epithelium☆ (1990) (0)
- 5‐HT2C receptor RNA editing in the amygdala of inbred mouse strains (2006) (0)
- Unraveling the Role of G‐proteins in Hallucinogenic Drug Action (2007) (0)
- Synthesis andN-methylation of -14C-p-chloroamphetamine hydrochloride (1976) (0)
- Role of serotonin 5HT1c receptors in the regulation of protein synthesis by choroid plexus epithelial cells in culture (1990) (0)
- Fridolin Sulser (2016) (0)
- In‐Vivo Functional Properties of the Fully Edited 5‐HT2C Receptor (2009) (0)
- Chapter 17 – Serotonin Receptors and Neurotransmission (2012) (0)
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