Elizabeth H. Head
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Elizabeth H. Headbiology Degrees
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Molecular Biology
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Biochemistry
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Chemistry Biology
Elizabeth H. Head's Degrees
- PhD Biochemistry Stanford University
Why Is Elizabeth H. Head Influential?
(Suggest an Edit or Addition)Elizabeth H. Head's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis (2003) (3868)
- Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease (2011) (1656)
- Analysis of shared heritability in common disorders of the brain (2016) (1385)
- Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers (2007) (709)
- Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid (2002) (548)
- Gene expression changes in the course of normal brain aging are sexually dimorphic (2008) (486)
- Clinical and pathological evidence for a frontal variant of Alzheimer disease. (1999) (390)
- Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer* (2009) (334)
- Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction (2009) (315)
- Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis (2012) (308)
- Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies (2011) (296)
- Common variants at MS 4 A 4 / MS 4 A 6 E , CD 2 AP , CD 33 and EPHA 1 are associated with late-onset Alzheimer ’ s disease (2011) (274)
- The canine as an animal model of human aging and dementia (1996) (267)
- Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain (2002) (251)
- Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need (2018) (247)
- Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease (2011) (242)
- Nutrition, Brain Aging, and Neurodegeneration (2009) (240)
- Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity (2014) (239)
- Alzheimer disease and Down syndrome: factors in pathogenesis (2005) (226)
- β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine (1996) (210)
- Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease (2008) (194)
- Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease (2010) (190)
- Oxidative damage increases with age in a canine model of human brain aging (2002) (188)
- Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. (2003) (181)
- Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. (2015) (181)
- Activation of Caspase-8 in the Alzheimer's Disease Brain (2001) (174)
- Dementia in Down syndrome: unique insights for Alzheimer disease research (2019) (173)
- Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. (2001) (172)
- APOE ε2 is associated with intact cognition but increased Alzheimer pathology in the oldest old (2009) (172)
- The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. (2008) (170)
- Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction (2002) (159)
- Visual-discrimination learning ability and β-amyloid accumulation in the dog (1998) (157)
- Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. (2008) (156)
- Down syndrome and Alzheimer's disease: a link between development and aging. (2001) (156)
- Alzheimer's Disease in Down Syndrome. (2012) (149)
- Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers (2010) (146)
- Spatial learning and memory as a function of age in the dog. (1995) (145)
- Dietary enrichment counteracts age-associated cognitive dysfunction in canines (2002) (140)
- Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. (2014) (140)
- Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. (2010) (138)
- Region-specific age at onset of β-amyloid in dogs☆ (2000) (137)
- Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy (2002) (132)
- Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain (2007) (131)
- Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. (1994) (130)
- Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. (2014) (128)
- Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2 (2008) (128)
- Diffuse plaques contain C-terminal Aβ 42 and not Aβ 40: Evidence from cats and dogs (1996) (127)
- Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function (2007) (125)
- Frontal Lobe Volume, Function, and β-Amyloid Pathology in a Canine Model of Aging (2004) (124)
- Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs (2004) (124)
- Neuroprotective effects of cognitive enrichment (2006) (121)
- Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation (2011) (120)
- Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study (2004) (120)
- Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging (1998) (118)
- Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. (2006) (118)
- Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease (2011) (116)
- Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia (2006) (115)
- Down syndrome and beta-amyloid deposition (2004) (115)
- Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks (1994) (114)
- Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. (2002) (113)
- Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. (1995) (112)
- Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging (2009) (111)
- Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. (2017) (111)
- Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. (2013) (110)
- Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. (2012) (109)
- A canine model of human aging and Alzheimer's disease. (2013) (109)
- Comparison of the Effects of l‐Carnitine and Acetyl‐l‐Carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats (2004) (109)
- Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy (2008) (107)
- Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog (2000) (105)
- Beta-amyloid, oxidative stress and down syndrome. (2006) (100)
- β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats (2005) (99)
- Region specific neuron loss in the aged canine hippocampus is reduced by enrichment (2008) (98)
- Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels as a Central Target for the Development of Human AD and AD‐Like Pathology in Aged Transgenic Mice (2002) (97)
- Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease (2021) (97)
- Synaptic proteins, neuropathology and cognitive status in the oldest-old (2009) (97)
- Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease (2003) (95)
- Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. (2014) (94)
- Complement Association with Neurons and β-Amyloid Deposition in the Brains of Aged Individuals with Down Syndrome (2001) (94)
- BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog (2010) (93)
- Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases (2016) (93)
- Landmark discrimination learning in the dog. (1999) (89)
- Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble But Not Soluble/Oligomeric Aβ Species in Amyloid Precursor Protein Transgenic Mice (2007) (88)
- An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease (2012) (88)
- Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. (2014) (88)
- Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. (2011) (88)
- A Two-Year Study with Fibrillar β-Amyloid (Aβ) Immunization in Aged Canines: Effects on Cognitive Function and Brain Aβ (2008) (85)
- Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. (2014) (85)
- Cognitive dysfunction and the neurobiology of ageing in cats. (2007) (85)
- Early Brain Injury Alters the Blood–Brain Barrier Phenotype in Parallel with β-Amyloid and Cognitive Changes in Adulthood (2013) (83)
- Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. (2007) (81)
- ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons (2005) (80)
- The progression of β-amyloid deposition in the frontal cortex of the aged canine (1997) (80)
- Aging and Down Syndrome (2012) (79)
- Frontal cortex neuropathology in dementia pugilistica. (2012) (78)
- Chromosome 21-derived MicroRNAs Provide an Etiological Basis for Aberrant Protein Expression in Human Down Syndrome Brains* (2009) (73)
- Frontal white matter integrity in adults with Down syndrome with and without dementia (2014) (73)
- Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging (2009) (73)
- Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain (2002) (71)
- Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? (2009) (70)
- Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human down syndrome brains. (2013) (69)
- Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. (2014) (69)
- Visual-discrimination learning ability and beta-amyloid accumulation in the dog. (1998) (68)
- Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. (2010) (68)
- Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy (2010) (67)
- Translational models for vascular cognitive impairment: a review including larger species (2017) (67)
- Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. (2011) (67)
- Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease (2015) (67)
- Locomotor activity rhythms in dogs vary with age and cognitive status. (2003) (66)
- Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. (2012) (65)
- Region-specific age at onset of beta-amyloid in dogs. (2000) (65)
- Biliverdin reductase‐A: a novel drug target for atorvastatin in a dog pre‐clinical model of Alzheimer disease (2012) (64)
- mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease‐like dementia (2018) (63)
- Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging (2006) (62)
- Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. (2008) (62)
- Ageing changes in cat brains demonstrated by β-amyloid and AT8-immunoreactive phosphorylated tau deposits (2006) (61)
- Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome (2001) (61)
- Neuroimaging of individuals with Down’s syndrome at-risk for dementia: Evidence for possible compensatory events (2008) (61)
- Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia (2003) (61)
- Ultrastructural evidence of fibrillar β-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains (2000) (59)
- Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis (2010) (59)
- Molecular Dating of Senile Plaques in the Brains of Individuals with Down Syndrome and in Aged Dogs (2000) (58)
- Generation and characterization of the humoral immune response to DNA immunization with a chimeric β‐amyloid‐interleukin‐4 minigene (2003) (58)
- Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and α-synuclein pathology (2005) (56)
- Learning and memory as a function of age in Down syndrome: A study using animal-based tasks (2005) (56)
- Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression (1995) (56)
- The Presence of Isoaspartic Acid in β-Amyloid Plaques Indicates Plaque Age (1999) (56)
- Development of a protocol for studying object recognition memory in the dog (2000) (56)
- BACE2 expression increases in human neurodegenerative disease. (2012) (54)
- Aging in the canine and feline brain. (2014) (54)
- Open Field Activity and Human Interaction as a Function of Age and Breed in Dogs (1997) (53)
- Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. (2015) (53)
- A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging (2005) (53)
- Synergistic Effects of Long-Term Antioxidant Diet and Behavioral Enrichment on β-Amyloid Load and Non-Amyloidogenic Processing in Aged Canines (2010) (51)
- Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging (2017) (51)
- Neurobiology of the aging dog (2011) (50)
- Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. (1996) (49)
- Neurobiological Models of Aging in the Dog and Other Vertebrate Species (2001) (48)
- Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. (2002) (48)
- Cerebrovascular pathology in Down syndrome and Alzheimer disease (2017) (48)
- (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. (1994) (45)
- Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. (2016) (45)
- Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. (2014) (44)
- A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain (2009) (42)
- The effect ofl-deprenyl on behavior, cognitive function, and biogenic amines in the dog (1993) (41)
- Caspase Activation in Alzheimer's Disease: Early to Rise and Late to Bed (2008) (41)
- A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog (2005) (41)
- Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease (2017) (41)
- Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. (2010) (40)
- Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. (2007) (40)
- Alzheimer's disease associated with Down syndrome: a genetic form of dementia (2021) (39)
- Rarity of the Alzheimer disease-protective APP A673T variant in the United States. (2015) (39)
- Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome (2020) (38)
- Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration (2014) (38)
- Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease (2018) (37)
- Effects of extended electrical kindling on exploratory behavior and spatial learning (1997) (37)
- Further understanding the connection between Alzheimer's disease and Down syndrome (2020) (37)
- HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. (2017) (37)
- Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs (2005) (36)
- Protective effects of R‐alpha‐lipoic acid and acetyl‐L‐carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid (2008) (35)
- Combining an Antioxidant‐Fortified Diet with Behavioral Enrichment Leads to Cognitive Improvement and Reduced Brain Pathology in Aging Canines (2007) (35)
- Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging (2005) (35)
- Insights into Aβ and Presenilin from a Canine Model of Human Brain Aging (2002) (35)
- Isolated Executive Impairment and Associated Frontal Neuropathology (2004) (35)
- Juvenile Traumatic Brain Injury Induces Long-Term Perivascular Matrix Changes Alongside Amyloid-Beta Accumulation (2014) (35)
- Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. (2001) (34)
- Ultrastructural analyses of β-amyloid in the aged dog brain: Neuronal β-amyloid is localized to the plasma membrane (2000) (34)
- Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. (2018) (33)
- Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. (2001) (33)
- Intersectin 1 contributes to phenotypes in vivo: implications for Down’s syndrome (2011) (33)
- The progression of beta-amyloid deposition in the frontal cortex of the aged canine. (1997) (33)
- Prevention approaches in a preclinical canine model of Alzheimer’s disease: benefits and challenges (2014) (33)
- Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism. (2018) (32)
- Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks (2004) (32)
- BioVision: An application for the automated image analysis of histological sections (2006) (32)
- Dissociation of Neuropathologic Findings and Cognition: Case Report of an Apolipoprotein E ε2/ε2 Genotype (2007) (32)
- Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy (2013) (31)
- The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodology (2020) (31)
- Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. (2016) (31)
- Parallel Compensatory and Pathological Events Associated with Tau Pathology in Middle Aged Individuals with Down Syndrome (2003) (31)
- Neuropathological correlates of amyloid PET imaging in Down syndrome (2019) (31)
- Changes in spontaneous behavior in the dog following oral administration of L-deprenyl (1992) (30)
- 1H-MRS metabolites in adults with Down syndrome: Effects of dementia (2016) (28)
- A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. (2012) (28)
- Antioxidants in the canine model of human aging. (2012) (26)
- Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms (2016) (26)
- Alzheimer‐Related Cerebrovascular Disease in Down Syndrome (2020) (25)
- Reduced neuronal expression of synaptic transmission modulator HNK‐1/neural cell adhesion molecule as a potential consequence of amyloid β‐mediated oxidative stress: a proteomic approach (2005) (25)
- Short-term supplementation with acetyl-l-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles (2009) (24)
- Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease (2019) (24)
- Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome (2020) (24)
- Initiation and propagation of molecular cascades in human brain aging: Insight from the canine model to promote successful aging (2000) (24)
- The effects of L-deprenyl on spatial short term memory in young and aged dogs (1996) (24)
- Nutritional management of brain aging in dogs. (2005) (24)
- Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (24)
- Down syndrome, beta-amyloid and neuroimaging. (2018) (24)
- Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines (2012) (24)
- A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. (2016) (23)
- Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta (2010) (23)
- Effects of chronic oral administration of l-deprenyl in the dog (1995) (23)
- Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging - eScholarship (2004) (23)
- An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. (2014) (23)
- β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome (2002) (22)
- Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? (2014) (22)
- The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. (1999) (22)
- APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease (2020) (21)
- Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review (2019) (20)
- Identification of neuronal plasma membrane microdomains that colocalize β-amyloid and presenilin: implications for β-amyloid precursor protein processing (2003) (20)
- Immunization with fibrillar Aβ1–42 in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Aβ (2006) (20)
- Spatial patterns of mammalian brain aging: Distribution of cathepsin D–immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease (2003) (19)
- Nutraceuticals, aging, and cognitive dysfunction. (2004) (19)
- Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. (2007) (19)
- Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. (2019) (19)
- Coenzyme Q10 and cognition in atorvastatin treated dogs (2011) (18)
- Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. (2020) (18)
- Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan (2017) (18)
- Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages (2017) (17)
- Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome (2020) (17)
- Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model (2011) (17)
- Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis (2018) (17)
- Opportunities, barriers, and recommendations in down syndrome research (2021) (17)
- Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice (2022) (16)
- APOE (cid:1) 2 is associated with intact cognition but increased Alzheimer pathology in the oldest old (2009) (16)
- Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease (2021) (15)
- Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels (2012) (15)
- Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study (2020) (14)
- Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention (2020) (14)
- Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. (2000) (14)
- Relapsing polychondritis with features of dementia with Lewy bodies (2006) (14)
- Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging (2005) (13)
- Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. (2003) (13)
- Effects of L‐Deprenyl on Manifestations of Aging in the Rat and Dog (1994) (13)
- Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. (2009) (13)
- Canine cognition, aging and neuropathology (2000) (12)
- An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers (2018) (12)
- Therapeutic actions of L-deprenyl in dogs: a model of human brain aging. (1998) (12)
- The AT(N) framework for Alzheimer's disease in adults with Down syndrome. (2020) (12)
- Erratum: Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs (Journal of Alzheimer's Disease (2010) 22:1 (135-150) DOI: 10.3233/JAD-2010-100639) (2011) (12)
- Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer’s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study (2021) (11)
- Response latency in Canis familiaris: mental ability or mental strategy? (2003) (10)
- Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. (2017) (10)
- Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. (2006) (9)
- Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease (2021) (8)
- Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines (2009) (8)
- Deposition of phosphorylated amyloid‐β in brains of aged nonhuman primates and canines (2018) (8)
- Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model (2021) (8)
- Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society (2018) (7)
- Oxidative Stress and mTOR Activation in Down Syndrome Brain: Roles in Aβ42 and Tau Neuropathology and Transition to Alzheimer Disease-Like Dementia (2017) (6)
- Oxidative Stress, Aging and CNS disease in the Canine Model of Human Brain Aging (2008) (6)
- Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures (1998) (6)
- Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. (2009) (6)
- Con: are we ready to translate Alzheimer’s disease-modifying therapies to people with down syndrome? (2014) (6)
- Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain (2016) (6)
- DOWN SYNDROME: AGE-DEPENDENCE OF PIB BINDING IN POSTMORTEM FRONTAL CORTEX ACROSS THE LIFESPAN (2017) (6)
- Longitudinal assessment of dementia measures in Down syndrome (2020) (6)
- Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain (2021) (5)
- A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease (2022) (4)
- Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome (2022) (4)
- Erratum: Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human down syndrome brains (Journal of Biological Chemistry (2010) 285 (1529-1543)) (2013) (4)
- Neuropathology of Feline Dementia (2017) (4)
- Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines (2008) (4)
- Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease† (2007) (4)
- Retraction notice to "Human chromosome 21-derived miRNAs are over-expressed in down syndrome brains and hearts" [Biochem. Biophys. Res. Commun. 370 (2008) 473-477]. (2013) (4)
- Brain–Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method (2019) (4)
- Commentary: Building the Older Adult Fall Prevention Movement – Steps and Lessons Learned (2016) (3)
- Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils. (2016) (3)
- Amyloid β -Peptide and Oligomers in the Brain and CSF of Aged Canines (2010) (3)
- A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. (2020) (3)
- Chapter 4 – Aging and Effects on Behavior (2004) (3)
- Canine cognition, aging and neuropathology. Introduction. (2000) (3)
- Oxidative Stress, Cognitive Dysfunction, and Brain Aging (2011) (2)
- 18F-Fluoropropyl curcumin: A potential PET tracer for imaging inflammation and A{beta}-plaques (2007) (2)
- The Dog as a Model for Aging Research (2018) (2)
- Neuropathology of Aging in Cats and its Similarities to Human Alzheimer’s Disease (2021) (2)
- Chapter 15 – Down Syndrome (2015) (2)
- 18F-fluoropropyl curcumin binding to β-amyloid plaques in transgenic mouse model of Alzheimer's disease (2008) (2)
- 18F-FBM: A new PET radiotracer for imaging {beta}-amyloid plaques and neurofibrillary tangles (2006) (2)
- 18F-Mefway binding to serotonin 5HT1A receptors is reduced in transgenic mouse models of Alzheimer's disease (2007) (2)
- Aβ and tau prions feature in the neuropathogenesis of Down syndrome (2022) (2)
- Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (2)
- Biomarkers in Down syndrome can help us understand Alzheimer's disease (2020) (2)
- Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy (2018) (2)
- Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome (2021) (2)
- A Novel liposomal nanoparticle for the imaging of amyloid plaque by MRI (2016) (1)
- Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease (2021) (1)
- Brain Aging in the Dog (2017) (1)
- The contribution of inflammation to Alzheimer's disease in Down syndrome (2022) (1)
- Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. (2022) (1)
- Antioxidants Combined with Behavioral Enrichment Can Slow Brain Aging (2010) (1)
- Reduction of dopamine D2/D3 receptors in transgenic mouse models of Alzheimer's disease (2007) (1)
- APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. (2021) (1)
- Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates (2010) (1)
- Subject Index Vol. 17, 2004 (2004) (1)
- Iconography : Aging in the Canine and Feline Brain (2014) (1)
- C1Q and inflammation in Down syndrome pathogenesis (2000) (1)
- Commentary on Oeckl et al., “Serum Beta‐Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181” (2022) (1)
- Biliverdin reductase-A: A novel drug target for atorvastatin in a dog preclinical model of Alzheimer’s disease (2012) (1)
- FRONTAL CORTEX MICROHEMORRHAGES IN AGING ADULTS WITH DOWN SYNDROME: A POTENTIALLY IMPORTANT CONTRIBUTOR TO ALZHEIMER’S DISEASE PATHOGENESIS (2016) (1)
- Alzheimer's disease in aging Down syndrome (2019) (1)
- Potential Therapeutic Effects of Statins in Alzheimer’s Disease (2014) (1)
- Single‐cell multi‐omics analysis identifies dynamic regulation of SREBF1 in Alzheimer’s disease (2021) (1)
- Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome (2022) (1)
- Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities. (2021) (1)
- Use of Voxel-based Morphometry Techniques to Assess the Benefits of an Antioxidant Diet in Preventing Cortical Atrophy in a Dog Model of Brain Aging (2005) (1)
- Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome. (2021) (1)
- A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. (2016) (0)
- Transcriptional profile of the aging canine brain (2010) (0)
- Nicotinic {alpha}4{beta}2 receptors in transgenic mice models of Alzheimer's disease (2007) (0)
- In Vivo Brain Imaging in Down Syndrome: Functional and Structural Similarities with Alzheimer’s Disease (2015) (0)
- Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain (2016) (0)
- Editorial Aging and Down Syndrome (2018) (0)
- Cognition, Aging, and the Development of Dementia in Down Syndrome (2019) (0)
- 56 - Disturbance of Protein Oxidation/degradation Homeostasis in Down Syndrome Brain Contributes to the Development of Alzheimer-Like Dementia (2015) (0)
- Spatial attention is improved in aged canines treated with a medical food cocktail (2012) (0)
- Effects of acetyl-L-carnitine and Lipoic Acid supplementation on cognition in aged beagles (2010) (0)
- 18F-Fluoropropyl curcumin: Improved radiosynthesis and binding to {beta}-amyloid plaques in a transgenic mouse model of Alzheimer's disease (2008) (0)
- CEREBROVASCULAR NEUROPATHOLOGY AS A FUNCTION OF AGE IN DOWN SYNDROME (2018) (0)
- Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults (2023) (0)
- ABERRANT POLYUBIQUITOME PROFILE IN DOWN SYNDROME AND ALZHEIMER DISEASE BRAIN (2017) (0)
- Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults (2022) (0)
- Lewy Body Pathology and Alzheimer Disease in Down Syndrome (2022) (0)
- Aging 1-2018 Down Syndrome , Beta-Amyloid and Neuroimaging (2019) (0)
- Changes in {beta}-secretase activity in down syndrome and aging (2009) (0)
- CAA and related co‐morbidities in Down syndrome and Alzheimer disease (2021) (0)
- Evaluation of 18F-nifrolene binding to transgenic mice model of Alzheimer's disease (2008) (0)
- The Effects of Antioxidants and Experience on the Development of Age Dependent Cognitive Dysfunction and Neuropathology in Canines (2000) (0)
- LOSSES IN FRONTAL WHITE MATTER INTEGRITY IN ADULTS WITH DOWN SYNDROME WITH AND WITHOUT DEMENTIA (2014) (0)
- Cross‐sectional and longitudinal associations of white matter hyperintensities and cortical thickness in the biomarkers of Alzheimer’s Disease in Down Syndrome (ADDS) study (2020) (0)
- The role of cerebrovascular disease in aging and Alzheimer's disease among people with Down syndrome (2022) (0)
- Mild Cognitive Impairment: Pivotal Cingulate Damage in Amnestic and Dysexecutive Subgroups (2009) (0)
- Dissociation of Neuropathologic Findings and Cognition (2016) (0)
- Antioxidant supplementation and the course of dementia in down syndrome (2010) (0)
- Effect of calcineurin inhibitors on cognition in a canine model of Alzheimer’s disease (2022) (0)
- Title An amyloid β 42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer ' s disease Permalink (2012) (0)
- Changes in β‐secretase activity in down syndrome and aging (2009) (0)
- Impact of Aging on Brain Structure and Function in Rodents and Canines (2011) (0)
- 5. Molecular dating of senile plaques in the brains of individuals with Down syndrome. (2000) (0)
- Omega-3 fatty acid deficit in Alzheimer's disease (2009) (0)
- A longitudinal study of aging and the development of Alzheimer's disease in people with Down syndrome (2012) (0)
- P1-119: Caspase-cleavage of the amyloid precursor protein is prevented in a triple transgenic mouse model of Alzheimer's disease following overexpression of Bcl-2 (2008) (0)
- Effect of an Antioxidant-Diet and Cognitive Enrichment on Age-Dependent Cognitive Dysfunction in Dogs (2005) (0)
- THE EARLY ONSET OF BRAIN INSULIN RESISTANCE IN DOWN SYNDROME: ROLE OF TRIPLICATED MIR802 (2019) (0)
- P3.066 Neuropathological characterization of posttranslationally modifled a-synuclein in PD and DLB (2009) (0)
- Diet and Brain Aging (2013) (0)
- Contents Vol. 17, 2004 (2004) (0)
- Evaluation of serotonin receptors using 18F-trans-Mefway in aging canine model (2009) (0)
- Development of a VBM Protocol for Assessing Regional Gray and White Matter Brain Changes in a Canine Model of Aging (2006) (0)
- Alzheimer’s Disease associations of ferritin and glutathione with oxidative damage and neuronal loss (2023) (0)
- Immunological animal models for the immunotherapy against Alzheimer’s disease (81.13) (2009) (0)
- Flow cytometry detection of inflammatory markers in glial cells and synaptosomes derived from AD cortex (2020) (0)
- O3-13-02 CHRONIC TREATMENT WITH A CNTF-DERIVED PEPTIDE REVERSES DENDRITIC AND SYNAPTIC PLASTICITY DEFICITS, COGNITIVE IMPAIRMENTAND TAU PATHOLOGY IN AN ALZHEIMER’S DISEASE MOUSE MODEL (2013) (0)
- Degeneration in Canine Brain Aging (2008) (0)
- CEREBRAL AMYLOID ANGIOPATHY AND MICROHEMORRHAGES IN THE OCCIPITAL CORTEX OF AGING ADULTS WITH DOWN SYNDROME (2017) (0)
- Nutritional Antioxidant Enrichment and Improved Cognitive Function in Canines (2005) (0)
- 77 Somatic mtDNA control region mutations and their effects in down syndrome with Alzheimer dementia (2007) (0)
- Title: Frontal Lobe Volume, Function, and A (cid:1) Pathology in a Canine Model of Aging Abbreviated Title: Frontal Lobe Volume and Aging in the Beagle (2005) (0)
- P3-212 Caspase-cleaved tau accumulation in Pick's disease, Lewy body disease and frontotemporal dementia (2004) (0)
- Evaluation of 18F-FBM for imaging β-amyloid plaques and neurofibrillary tangles (2008) (0)
- Gene expression changes as a function of age in beagles: preliminary results (2010) (0)
- Title Assessing general cognitive and adaptive abilities in adults with Down syndrome : a systematic review (2019) (0)
- Longitudinal plasma levels of neurofilament light in Down syndrome: A multicenter study (2020) (0)
- Immunological dysfunction and MCI-like behavior in the 3xTgAD mice (2013) (0)
- P2-008 β-Amyloid accumulation and tau phosphorylation in the aged cat brain: comparison with Alzheimer's disease and Down syndrome (2004) (0)
- Microglial phenotypes in the brains of aging people with Down syndrome and Alzheimer disease (2020) (0)
- O1-01-04 Inflammatory cell infiltrates are commonly associated with brain vasculature and cerebral amyloid angiopathy in Alzheimer’s disease (2006) (0)
- A COMBINATION APPROACH IN A CANINE MODEL OF AGING: IMMUNOTHERAPY WITH BEHAVIORAL ENRICHMENT (2014) (0)
- P3-066 Changes in frontal lobe volume, executive function, and amyloid load in a canine model of aging (2004) (0)
- Biliverdin reductase-A: A novel drug target for atorvastatin and relevance to statin-mediated reduced risk of developing Alzheimer’s disease (2013) (0)
- 20 - Proteomics Insights into Molecular Mechanisms Engaged Prior to and Following Development of Alzheimer’s Disease (AD) Neuropathology in Down Syndrome (DS) Brain: Relevance to Oxidative Stress and Neuropathology of Both DS and AD (2014) (0)
- Autoradiographic studies of transgenic (Tg2576) mice with 18F-nifene and 18F-FDDNP (2006) (0)
- Single‐nucleus open chromatin accessibility landscape of Pick’s and Alzheimer’s disease (2022) (0)
- Validity of the severe impairment battery, brief praxis test, and dementia questionnaire for persons with intellectual disabilities in differentiating dementia status in individuals with Down syndrome (2020) (0)
- Frontal Release Signs in Adults with Down Syndrome Are Associated with Dementia (P3.198) (2014) (0)
- Autoradiographic studies 18F-FDNNP and 18F-FBM in transgenic mouse models (2007) (0)
- Targeting Mitochondria for Healthy Brain Aging (2015) (0)
- Ubiquitome Profile in Down Syndrome Brain: Understanding the Mechanisms of Neurodegeneration (2016) (0)
- Excess Synaptojanin 1 Co ntributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer ’ s Disease Graphical Abstract Highlights (0)
- Feasibility of dual‐task gait to estimate Alzheimer's related cognitive decline in Down syndrome (2020) (0)
- Increased plasma DYRK1A with aging may protect against neurodegenerative diseases (2023) (0)
- Alzheimer’s disease and Down syndrome (2020) (0)
- O4-05-03: The apolipoprotein E-epsilon 2 allele is associated with increased Alzheimer neuropathology but preserved cognition: Findings from the 90+ study (2008) (0)
- Micronutrient Antioxidants, Cognition, and Neuropathology: A Longitudinal Study in the Canine Model of Human Aging (2009) (0)
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What Schools Are Affiliated With Elizabeth H. Head?
Elizabeth H. Head is affiliated with the following schools:
