Elizabeth Iorns

Q: What Schools Are Affiliated With Elizabeth Iorns

Elizabeth Iorns is affiliated with the following schools: Institute of Cancer Research, University of Miami, University of Auckland

Elizabeth Iorns's AcademicInfluence.com Rankings

Elizabeth Iorns

Philosophy

#11498

World Rank

#15836

Historical Rank

Logic

#9274

World Rank

#11734

Historical Rank

philosophy Degrees

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Philosophy

Elizabeth Iorns's Degrees

PhD Cancer Biology University of Miami
Bachelors Biomedical Science University of Auckland

Why Is Elizabeth Iorns Influential?

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According to Wikipedia, Elizabeth Jane Iorns is a New Zealand scientist, entrepreneur and researcher, and the founder and CEO of Science Exchange, a Silicon Valley startup which operates a platform to allow scientists to outsource their research to scientific institutions such as university facilities or commercial contract research organizations. Science Exchange has received considerable media attention since it first launched in August 2011, particularly following its participation in the Y Combinator incubator program in Summer 2011 and its role in launching the Reproducibility Initiative in Summer 2012. Iorns has been profiled in many leading publications including Nature, FastCompany, the San Francisco Business Times and Xconomy. Iorns lives in Palo Alto, California, where Science Exchange is now headquartered.

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Elizabeth Iorns's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. (2010) (631)
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor (2008) (318)
Utilizing RNA interference to enhance cancer drug discovery (2007) (258)
An open investigation of the reproducibility of cancer biology research (2014) (221)
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer. (2008) (205)
A New Mouse Model for the Study of Human Breast Cancer Metastasis (2012) (147)
Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets (2009) (125)
The role of SATB1 in breast cancer pathogenesis. (2010) (73)
Investigating the replicability of preclinical cancer biology (2021) (66)
Reproducibility Project: Cancer Biology (2013) (62)
Challenges for assessing replicability in preclinical cancer biology (2021) (61)
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. (2009) (61)
Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor (2012) (57)
Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma (2018) (41)
PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells (2012) (39)
Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5 (2012) (38)
Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome (2014) (35)
Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc (2018) (28)
Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization (2012) (27)
Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET (2018) (26)
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. (2009) (22)
Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells (2018) (21)
Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 (2019) (15)
Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells (2015) (13)
Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion (2014) (12)
Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis (2019) (12)
Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development (2015) (12)
New forms of checks and balances are needed to improve research integrity (2014) (11)
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology (2021) (11)
Replication Attempt: “Effect of BMAP-28 Antimicrobial Peptides on Leishmania Major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival” (2014) (11)
Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models (2011) (10)
Truncated p 110 ERBB 2 induces mammary epithelial cell migration , invasion and orthotopic xenograft formation , and is associated with loss of phosphorylated STAT 5 (2012) (10)
Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota (2018) (10)
Tumor and Stem Cell Biology Cancer Research FGFR 1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer (2010) (9)
Registered report: Intestinal inflammation targets cancer-inducing activity of the microbiota (2015) (9)
Registered report: Transcriptional amplification in tumor cells with elevated c-Myc (2015) (9)
Registered report: androgen receptor splice variants determine taxane sensitivity in prostate cancer (2015) (8)
Reproducibility concerns (2012) (6)
Proceedings of the 4th World Conference on Research Integrity (2016) (6)
Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2019) (6)
Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations (2014) (6)
Registered report: The CD47-signal regulated protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors (2015) (4)
Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth (2021) (4)
Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs (2020) (4)
Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors (2014) (4)
Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology (2020) (4)
Replication study: androgen receptor splice variants determine taxane sensitivity in prostate cancer (2018) (3)
Study 19: Replication of Delmore et al., 2011 (Cell) (2013) (3)
Author response: An open investigation of the reproducibility of cancer biology research (2014) (3)
Dissecting resistance to endocrine therapy in breast cancer (2008) (3)
Study 16: Replication of Ward et al., 2010 (Cancer Cell) (2013) (2)
Study 39: Replication of Willingham et al., 2012 (PNAS) (2013) (2)
Study 21: Replication of Sirota et al., 2011 (Science Translational Medicine) (2013) (2)
Author response: Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc (2017) (2)
Study 44: Replication of Berger et al., 2012 (Nature) (2013) (2)
Study 15: Replication of Sugahara et al., 2010 (Science) (2013) (2)
Abstract 5053: Preliminary results from the Reproducibility Project: Cancer Biology - a replication of 50 high-impact cancer cell biology papers from 2010-2012 (2014) (1)
Mammosphere Culture of Established Cell Lines Does Not Enrich for a More Tumorigenic Breast Cancer Stem Cell Population. (2009) (1)
Next-Generation Sequencing for High-Throughput RNA Interference Screens (2013) (1)
PD01-09: Identifying Novel Mechanisms of Resistance to Lapatinib in ERBB2+ Breast Cancer Cells through Whole Genome Mutational Analysis. (2011) (1)
Study 48: Replication of Lin et al., 2012 (Cell) (2013) (1)
Abstract P3-14-14: Activation of SRC and MAPK Mediates Resistance to Lapatinib in ER-/ERBB2+ Breast Cancer (2010) (1)
Study 42: Replication of Peinado et al., 2012 (Nature Medicine) (2013) (1)
Study 20: Replication of Goetz et al., 2011 (Cell) (2013) (1)
Study 29: Replication of Dawson et al., 2011 (Nature) (2013) (1)
Study 50: Replication of Castellarin et al., 2012 (Genome Research) (2013) (1)
Author response: Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis (2019) (1)
Proceedings of the 4th World Conference on Research Integrity (2016) (1)
Study 1: Replication of Poliseno et al., 2010 (Nature) (2013) (1)
Study 28: Replication of Liu et al., 2011 (Nature Medicine) (2013) (1)
Study 9: Replication of Vermeulen et al., 2010 (Nature Cell Biology) (2013) (1)
Study 41: Replication of Arthur et al., 2012 (Science) (2013) (1)
366 days: Nature's 10 (2012) (1)
Study 24: Replication of Tay et al., 2011 (Cell) (2013) (1)
Registered report: the androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man (2015) (1)
Study 37: Replication of Garnett et al., 2012 (Nature) (2013) (1)
Abstract P4-07-03: Dynamic regulation of a microRNA-mRNA network during breast cancer metastasis reveals an essential tumor-promoting role for miR-203 (2017) (1)
Worth the paper it's on? (2012) (1)
Study 6: Replication of Kan et al., 2010 (Nature) (2013) (0)
Tumorigenicity assay of TOP-GFP CSC clone (2018) (0)
Study 26: De Nicola et al. 2011, Nature (2013) (0)
Study 43: Replication of Malanchi et al., 2012 (Nature) (2013) (0)
Assessment of maximum tolerated dose of I-BET151 in xenograft MLL mouse model (2016) (0)
Study 30: Qian et al. 2011, Nature (2013) (0)
Abstract P1-05-12: Metastatic xenograft models of human estrogen receptor negative breast cancer primary cultures are driven by the recruitment of myeloid-derived suppressor cells (2012) (0)
Isolation of colon cancer stem cells, infection with TOP-GFP, and flow cytometry analysis of CSC marker expression in TOP-GFP clones (2018) (0)
Study 14: Poulikakos et al. 2010, Nature (2013) (0)
Study 32: Chaffer et al. 2011, PNAS (2013) (0)
Quantitative PCR following siRNA transfection (2017) (0)
Cell growth assay following siRNA transfection (2017) (0)
Study 12: Johannessen et al. 2010, Nature (2013) (0)
Effect of Dox alone or Dox in combination with iRGD on tumor growth and total body weight (2015) (0)
Assessment of TUNEL staining of tumor and heart tissue after treatment (2016) (0)
Trends in research (2015) (0)
Luciferase assays to assess putative miR-34a binding sites in the 3’UTR of CD44 (2016) (0)
Study 11: Nazarian et al. 2010, Nature (2013) (0)
Isolation and characterization of Cav1 WT and Cav1 KO primary MEFs (2016) (0)
Confirming ectopic expression of PREX2 mutant isoforms by Western blot (2016) (0)
Generation of tumor xenografts expressing PREX2 isoforms and evaluation of tumor free survival and tumor growth (2016) (0)
Effect of miR-34a on tumor growth and CD44 expression in LAPC4 tumor tissue (2017) (0)
Study 48: Lin et al. 2012, Cell (2013) (0)
Study 10: Carro et al. 2010, Nature (2013) (0)
Analysis of BCL2 gene expression following I-BET151 treatment (2015) (0)
Study 49: Lee et al. 2012, Cell (2013) (0)
Abstract P5-05-02: Whole Genome In Vivo RNA Interference Screening Identifies the Leukemia Inhibitory Factor Receptor as a Novel Breast Tumor Suppressor (2010) (0)
Author response: Investigating the replicability of preclinical cancer biology (2021) (0)
Author response: Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 (2019) (0)
Study 7: Replication of Heidorn et al., 2010 (Cell) (2013) (0)
Study 24: Tay et al. 2011, Cell (2013) (0)
Testing the efficacy of JQ1 treatment in mice harboring bioluminescent MM lesions (2016) (0)
Study 18: Zuber et al. 2011, Nature (2013) (0)
Replication reporting standards variables, review, and support (2014) (0)
Study 21: Sirota et al. 2011, Science Translational Medicine (2013) (0)
Study 22: Raj et al. 2011, Nature (2013) (0)
Sequencing of endogenous PREX2 in NRAS-G12D melanocytes (2016) (0)
Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens (2009) (0)
Generation and characterization of shMet B16-F10 cells and exosomes (2016) (0)
Author response: Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma (2017) (0)
Abstract 3986: Science Exchange: An integrated platform for experiment outsourcing (2012) (0)
Study 2: Replication of Sharma et al., 2010 (Cell) (2013) (0)
Author response: Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology (2020) (0)
Study 46: Wilson et al. 2012, Nature (2013) (0)
Author response: Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET (2018) (0)
Study 3: Gupta et al. 2010, Nature (2013) (0)
Generation of disseminated xenograft MLL mouse model and testing of I-BET151 compound in vivo (2016) (0)
Quantitative PCR for amplification of F. nucleatum from matched normal and tumor human colon cancer specimens (2016) (0)
Western blot assay following siRNA transfection (2017) (0)
Assessing 2HG levels in AML patient samples (2016) (0)
Author response: Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology (2021) (0)
Using Market‐Driven Collaboration to Accelerate Innovation in Biomedicine (2014) (0)
Author response: Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells (2017) (0)
Author response: Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota (2018) (0)
Expression of miR-34a in LAPC4 sub-populations (2018) (0)
Study 23: Possemato et al. 2011, Nature (2013) (0)
Quantitative PCR following PTEN 3′ UTR transfection (2016) (0)
Study 34: Kang et al. 2011, Nature (2013) (0)
Olaparib sensitivity after depletion of EWS-FLI1 from A673 cells (2017) (0)
Study 17: Ko et al. 2010, Nature (2013) (0)
Registered Report: The transcriptional network for mesenchymal transformation of brain tumours (2016) (0)
Identifying Breast Tumor Suppressors Using in Vitro and in Vivo RNAi Screens (2011) (0)
Sensitivity to olaparib in cells transformed with the EWS-FLI1 rearrangement (2017) (0)
Study 38: Schepers et al. 2012, Science (2013) (0)
Study 27: Zhu et al. 2011, Nature (2013) (0)
Western blot of c-Myc reactivation in tetracyclic-repressible system and total RNA expression during c-Myc re-activation (2016) (0)
Study 29: Dawson et al. 2011, Nature (2013) (0)
Study 47: Replication of Lu et al., 2012. (Nature) (2013) (0)
Study 7: Heidorn et al. 2010, Cell (2013) (0)
Practicalities of conducting.qxp_Layout 1 (2018) (0)
Study 12: Replication of Johannessen et al., 2010 (Nature) (2013) (0)
Abstract P5-06-03: Truncated ERBB2 Receptors: Diagnostic and Therapeutic Targets (2010) (0)
Evaluating the selective inhibition of a MLL-fusion leukemic cell line with I-BET151 (2015) (0)
Study 34: Replication of Kang et al., 2011 (Nature) (2013) (0)
Assessing the effect of cimetidine treatment on tumor growth (2015) (0)
Subcutaneous tumorigenicity assay of tumor cells co-injected with Cav1 WT or Cav1 KO primary MEFs (2017) (0)
Study 13: Kim et al. 2010, Cell (2013) (0)
Production of 2HG from wild-type or R172K mutant IDH2 transfected cells (2016) (0)
Study 40: Replication of Straussman et al., 2012 (Nature) (2013) (0)
Study 45: Prahallad et al. 2012, Nature (2013) (0)
Engraftment of mouse breast cancer cells and treatment with CD47 targeted antibodies (2015) (0)
Study 40: Straussman et al. 2012, Nature (2013) (0)
t he r ole of SAt B1 in Breast cancer Pathogenesis (2010) (0)
Study 33: Opitz et al. 2011, Nature (2013) (0)
PCR amplification and sequencing of polyketide synthase (pks) genotoxic island in E. coli NC101 and NC101∆pks (2017) (0)
Abstract 1211: Novel detection and characterization of truncated ERBB2 demonstrates potent oncogenicity of the p110 isoform in human mammary epithelial cells (2011) (0)
Study 46: Replication of Wilson et al., 2012 (Nature) (2013) (0)
Quantifying the amount of Dox present in tumor tissue and major organs in mice treated with Dox with or without iRGD (2016) (0)
Study 43: Malanchi et al. 2012, Nature (2013) (0)
P2-01-25: Truncated p110 ERBB2 (CTF611) Increases Migration and Invasion of Breast Epithelial Cells by Inhibiting STAT5b Activation. (2011) (0)
Study 5: Replication of Ricci-Vitiani et al., 2010 (Nature) (2014) (0)
Plasmid quality control data (2016) (0)
Study 12: Registered Report Additional Materials (2015) (0)
Study 25: Replication of Xu et al., 2011 (Cancer Cell) (2013) (0)
Author response: Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs (2020) (0)
Truncated p95erbB2Isoforms Are Capable of Transforming Human Mammary Epithelial Cells. (2009) (0)
Cell growth assay following PTEN 3′ UTR transfection (2017) (0)
Study 8: Replication of Hatzivassiliou et al., 2010 (Nature) (2013) (0)
Transcript levels during c-Myc re-activation and NanoString nCounter digital gene expression assay (2016) (0)
Study 44: Berger et al. 2012, Nature (2013) (0)
Assessing the isocitrate-dependent NADPH production and alpha-ketoglutarate-dependent NADPH consumption of wild-type or R172K mutant IDH2 (2016) (0)
Sensitivity of Ewing’s sarcoma cell lines to PARP inhibition (2017) (0)
Study 16: Ward et al. 2010, Cancer Cell (2013) (0)
Clonogenicity assay of TOP-GFP CSC clones (2018) (0)
Study 4: Figueroa et al. 2010, Cancer Cell (2013) (0)
Registered Report Additional Materials (2015) (0)
Intestinal tumorigenesis and inflammation of germ-free IL10-/- mice mono-associated with E. coli NC101 or NC101Δpks (2016) (0)
Evaluation of MYC expression in JQ1-treated MM.1S-luc cells (2016) (0)
Cell line quality control data (2016) (0)
Exosome-dependent MET signaling on primary tumor growth and metastasis (2017) (0)
Author response: Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis (2015) (0)
Study 35: Chen et al. 2012, Nature (2013) (0)
Author response: Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2019) (0)

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Other Resources About Elizabeth Iorns

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What Schools Are Affiliated With Elizabeth Iorns?

Elizabeth Iorns is affiliated with the following schools:

Elizabeth Iorns's Academic­Influence.com Rankings