Elizabeth Nolan
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American biochemist
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Elizabeth Nolanbiology Degrees
Biology
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Biochemistry
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Biology
Elizabeth Nolan's Degrees
- Bachelors Chemistry University of California, Berkeley
Why Is Elizabeth Nolan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Elizabeth Marie Nolan is an American chemist and associate professor at Massachusetts Institute of Technology. Early life and education Nolan was born in Niskayuna, New York. She studied at Smith College, where she majored in chemistry and graduated magna cum laude in 2000. During her undergraduate studies she minored in music and worked with Robert Linck on computational chemistry. She studied the stereoelectronic effects in substituted alkanes. Nolan was a member of Phi Beta Kappa. She was awarded a Fulbright Program Scholarship and moved to France to study siderophore-iron complexes. Nolan moved to Massachusetts Institute of Technology for her graduate studies, where she was supervised by Stephen J. Lippard. She developed small molecule fluorescent sensors to monitor for zinc in neurobiology and mercury in aqueous solutions. Together they filed a patent for Fluorescein-based metal sensors. Nolan was a postdoctoral scientist at the Harvard Medical School, working with Christopher T. Walsh on the biosynthetic assembly of microcin E492m. Microcin E492m is an antibiotic peptide that can target Gram-negative bacteria which express siderophore transporters. She was awarded a $2.5 million National Institutes of Health grant in 2010 to study antibacterial peptides and zinc in innate immunity. In 2011 she contributed to the book Letters to a Young Chemist.
Elizabeth Nolan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Tools and tactics for the optical detection of mercuric ion. (2008) (1942)
- A "turn-on" fluorescent sensor for the selective detection of mercuric ion in aqueous media. (2003) (532)
- Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry. (2009) (529)
- Turn-on and ratiometric mercury sensing in water with a red-emitting probe. (2007) (376)
- Beyond iron: non-classical biological functions of bacterial siderophores. (2015) (281)
- QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II). (2005) (215)
- Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization. (2006) (208)
- A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc. (2004) (190)
- Human Calprotectin Is an Iron-Sequestering Host-Defense Protein (2015) (186)
- Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells. (2008) (178)
- Selective Hg(II) detection in aqueous solution with thiol derivatized fluoresceins. (2006) (145)
- Calcium ion gradients modulate the zinc affinity and antibacterial activity of human calprotectin. (2012) (129)
- Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc. (2004) (124)
- Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform. (2004) (112)
- Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli (2014) (104)
- High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface. (2012) (103)
- How Nature Morphs Peptide Scaffolds into Antibiotics (2009) (103)
- Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase (2016) (102)
- Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery. (2009) (101)
- ZP8, a neuronal zinc sensor with improved dynamic range; imaging zinc in hippocampal slices with two-photon microscopy. (2004) (99)
- Transition Metal Sequestration by the Host-Defense Protein Calprotectin. (2018) (99)
- MS4, a seminaphthofluorescein-based chemosensor for the ratiometric detection of Hg(II) (2005) (91)
- The zinspy family of fluorescent zinc sensors: syntheses and spectroscopic investigations. (2004) (90)
- Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential? (2008) (89)
- Tools and Tactics for the Optical Detection of Mercuric Ion (2008) (85)
- CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases. (2007) (82)
- Siderophore-mediated cargo delivery to the cytoplasm of Escherichia coli and Pseudomonas aeruginosa: syntheses of monofunctionalized enterobactin scaffolds and evaluation of enterobactin-cargo conjugate uptake. (2012) (82)
- Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7. (2008) (80)
- Visualizing attack of Escherichia coli by the antimicrobial peptide human defensin 5. (2015) (79)
- Nickel Sequestration by the Host-Defense Protein Human Calprotectin. (2017) (76)
- Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity. (2018) (74)
- Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms (2015) (73)
- Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut (2016) (72)
- Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. (2007) (61)
- Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. (2009) (61)
- Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus. (2011) (60)
- Midrange affinity fluorescent Zn(II) sensors of the Zinpyr family: syntheses, characterization, and biological imaging applications. (2006) (60)
- Contributions of the S100A9 C-terminal tail to high-affinity Mn(II) chelation by the host-defense protein human calprotectin. (2013) (60)
- Molecular Basis for Self-Assembly of a Human Host-Defense Peptide That Entraps Bacterial Pathogens (2014) (59)
- Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. (2015) (53)
- Siderophore-based detection of Fe(III) and microbial pathogens. (2012) (49)
- Siderophore-based immunization strategy to inhibit growth of enteric pathogens (2016) (48)
- Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics. (2008) (48)
- Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12 (2015) (46)
- Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes. (2017) (45)
- The human innate immune protein calprotectin induces iron starvation responses in Pseudomonas aeruginosa (2019) (43)
- NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. (2012) (41)
- Reduction of human defensin 5 affords a high-affinity zinc-chelating peptide. (2013) (41)
- The State of the Art of Chemical Biology (2009) (40)
- The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility. (2016) (40)
- Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide (2014) (39)
- Calcium-induced tetramerization and zinc chelation shield human calprotectin from degradation by host and bacterial extracellular proteases (2015) (35)
- Chemical Synthesis of Staphyloferrin B Affords Insight into the Molecular Structure, Iron Chelation, and Biological Activity of a Polycarboxylate Siderophore Deployed by the Human Pathogen Staphylococcus aureus. (2015) (31)
- Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247 (2016) (31)
- Morphing peptide backbones into heterocycles (2008) (29)
- Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response. (2017) (29)
- Proteolysis triggers self-assembly and unmasks innate immune function of a human α-defensin peptide (2015) (27)
- Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore-antibiotic conjugates. (2015) (24)
- Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics (2018) (23)
- Human α-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans. (2017) (21)
- Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin). (2017) (21)
- Transition metals at the host-pathogen interface: how Neisseria exploit human metalloproteins for acquiring iron and zinc. (2017) (20)
- Human calprotectin affects the redox speciation of iron. (2017) (20)
- Determination of the Molecular Structures of Ferric Enterobactin and Ferric Enantioenterobactin Using Racemic Crystallography. (2017) (18)
- Charge Variations in Substituted Alkanes: Evidence for a Through-Space Effect (2000) (18)
- Extremity transplantation: a review of its current state of development. (1993) (16)
- Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins. (2018) (16)
- Oxidative Post-translational Modifications Accelerate Proteolytic Degradation of Calprotectin. (2018) (16)
- Metal Sequestration and Antimicrobial Activity of Human Calprotectin are pH-Dependent. (2020) (15)
- A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. (2018) (15)
- Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin. (2018) (14)
- Exploring Iron Withholding by the Innate Immune Protein Human Calprotectin. (2019) (12)
- A Bacterial Mutant Library as a Tool to Study the Attack of a Defensin Peptide (2014) (12)
- Initial Biochemical and Functional Evaluation of Murine Calprotectin Reveals Ca(II)-Dependence and Its Ability to Chelate Multiple Nutrient Transition Metal Ions. (2018) (11)
- Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. (2018) (11)
- Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous "black" pigment gallstone formation in germfree Swiss Webster mice. (2014) (10)
- Calprotectin influences the aggregation of metal-free and metal-bound amyloid-β by direct interaction. (2018) (10)
- Magnetic circular dichroism studies of iron(ii) binding to human calprotectin† †Electronic supplementary information (ESI) available: Sample details and supplemental magnetic circular dichroism spectra. See DOI: 10.1039/c6sc03487j Click here for additional data file. (2016) (10)
- Harnessing Iron Acquisition Machinery to Target Enterobacteriaceae. (2020) (9)
- Calcium Binding to the Innate Immune Protein Human Calprotectin Revealed by Integrated Mass Spectrometry. (2020) (9)
- Heme protects Pseudomonas aeruginosa and Staphylococcus aureus from calprotectin-induced iron starvation (2020) (7)
- Murine Calprotectin Coordinates Mn(II) at a Hexahistidine Site with Ca(II)-Dependent Affinity. (2019) (7)
- Magnetic circular dichroism studies of iron( II ) binding to human calprotectin † (2017) (7)
- Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli. (2022) (7)
- The Pneumococcal Iron Uptake Protein a (PiuA) Specifically Recognizes Tetradentate FeIIIbis- and Mono-Catechol Complexes. (2020) (7)
- Avian MRP126 Restricts Microbial Growth through Ca(II)-dependent Zn(II) Sequestration. (2019) (7)
- Bacterial Responses to Iron Withholding by Calprotectin. (2021) (6)
- Design, solid-phase synthesis and evaluation of enterobactin analogs for iron delivery into the human pathogen Campylobacter jejuni. (2018) (5)
- Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against Nontyphoidal Salmonella. (2021) (5)
- High-Field EPR Spectroscopic Characterization of Mn(II) Bound to the Bacterial Solute-Binding Proteins MntC and PsaA. (2019) (5)
- Siderophore Immunization Restricted Colonization of Adherent-Invasive Escherichia coli and Ameliorated Experimental Colitis (2022) (5)
- A metal shuttle keeps pathogens well fed (2016) (5)
- A Noncanonical Role for Yersiniabactin in Bacterial Copper Acquisition. (2017) (4)
- Metal sequestration by S100 proteins in chemically diverse environments. (2022) (4)
- Preparation and Iron Redox Speciation Study of the Fe(II)-Binding Antimicrobial Protein Calprotectin. (2019) (4)
- Molecular Basis of Ca(II)-Induced Tetramerization and Transition-Metal Sequestration in Human Calprotectin. (2021) (4)
- Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073† (2021) (3)
- The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa (2021) (3)
- A Sensitive, Nonradioactive Assay for Zn(II) Uptake into Metazoan Cells. (2018) (2)
- Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis (2015) (2)
- Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry (2009) (1)
- Preparation of the Oxidized and Reduced Forms of Psoriasin (S100A7). (2019) (1)
- Post-translational modifications on the metal-sequestering protein calprotectin. (2023) (1)
- Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC. (2022) (1)
- Metals and immunity (2017) (0)
- TARGETING SIDEROPHORES TO REDUCE COLONIZATION OF ADHERENT INVASIVE E. COLI IN CROHN’S DISEASE (2021) (0)
- Solution Structure of the Antimicrobial Peptide Human Defensin 5 (2012) (0)
- S100A12 promotes Mn(II) binding to pneumococcal PsaA and staphylococcal MntC by Zn(II) sequestration. (2022) (0)
- A Novel Method for Studying Zinc Deficiency in vitro and its Application (2018) (0)
- Fluorescent chemosensors for exploring zinc metalloneurochemistry and detecting mercury in aqueous solution (2006) (0)
- Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide (2014) (0)
- Let's Visualize Biology: Chemistry and Cellular Imaging (2011) (0)
- NMR Solution Structure and Condition-Dependent Oligomerization of the Antimicrobial Peptide Human Defensin 5 Citation Wommack (2013) (0)
- Metal homeostasis and infectious disease: siderophore-based strategies to inhibit growth of bacterial pathogens (2017) (0)
- Crystal structure of Ni(II)-bound human calprotectin (2018) (0)
- Faculty Opinions recommendation of Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms. (2017) (0)
- Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli. (2015) (0)
- How Nature Morphs Reptide Scaffolds into Antibiotics (2009) (0)
- Crystal structure of Ni(II)- and Ca(II)-bound human calprotectin (2017) (0)
- The human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa (2021) (0)
- Solution structure of oxidized dimeric form of human defensin 5 (2014) (0)
- Impaired Cholecystokinin-Induced Gallbladder Emptying Incriminated in 1 Spontaneous “ Black ” Pigment Gallstone Formation in Germfree (2015) (0)
- Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics (2018) (0)
- Editorial overview: bioinorganic chemistry: recent advances in bioinorganic chemistry. (2014) (0)
- Faculty Opinions recommendation of A four-helix bundle stores copper for methane oxidation. (2016) (0)
- Faculty Opinions recommendation of Human urinary composition controls antibacterial activity of siderocalin. (2016) (0)
- Faculty Opinions recommendation of Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. (2016) (0)
- Faculty of 1000 evaluation for Iron in infection and immunity. (2013) (0)
- Faculty Opinions recommendation of Cd2+ as a Ca2+ surrogate in protein-membrane interactions: isostructural but not isofunctional. (2013) (0)
- Faculty Opinions recommendation of A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. (2013) (0)
- Metals and immunity: Explorations of a biological hexahistidine site (2017) (0)
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