Elizabeth Rakoczy
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Hungarian-born molecular ophthalmologist
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Why Is Elizabeth Rakoczy Influential?
(Suggest an Edit or Addition)According to Wikipedia, Elizabeth P. Rakoczy is a Hungarian-born molecular ophthalmologist. She is a professor at the University of Western Australia. She started the molecular ophthalmology department at the Lions Eye Institute. In 2017, Rakoczy was awarded the Florey Medal for her human gene therapy trial to modify viruses for the treatment of wet age-related macular degeneration.
Elizabeth Rakoczy's Published Works
Published Works
- Lipofuscin of the retinal pigment epithelium: A review (1995) (374)
- Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. (2000) (370)
- Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog. (2003) (254)
- Differentiation of Marrow Stromal Cells into Photoreceptors in the Rat Eye (2003) (214)
- Adenovirus and adeno-associated virus vectors. (2002) (177)
- Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. (2002) (171)
- Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity (2005) (151)
- Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial (2015) (147)
- Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions (2007) (135)
- Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat (1998) (130)
- Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy (2013) (127)
- In vivo gene therapy in young and adult RPE65-/- dogs produces long-term visual improvement. (2003) (126)
- The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides (2001) (117)
- Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. (2005) (115)
- Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration (2016) (111)
- Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. (2001) (103)
- Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations. (2011) (96)
- Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. (2004) (91)
- Characterization of a mouse model of hyperglycemia and retinal neovascularization. (2010) (91)
- Recombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescue (2004) (87)
- Argon laser photocoagulation-induced modification of gene expression in the retina. (2003) (83)
- Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization. (2000) (67)
- Senescence of the retinal pigment epithelium. (1999) (64)
- Assessment of Structure and Function Over a 3-year Period after Gene Transfer in RPE65−/− dogs (2005) (64)
- Evaluation of adeno-associated virus-mediated gene transfer into the rat retina by clinical fluorescence photography. (1999) (63)
- Inhibition of corneal neovascularization by recombinant adenovirus mediated antisense VEGF RNA. (2002) (62)
- Modulation of cathepsin D activity in retinal pigment epithelial cells. (1997) (62)
- Generation of transgenic mice with mild and severe retinal neovascularisation (2005) (62)
- VEGF differentially regulates transcription and translation of ZO-1α+ and ZO-1α− and mediates trans-epithelial resistance in cultured endothelial and epithelial cells (2005) (61)
- Molecular analysis of blood-retinal barrier loss in the Akimba mouse, a model of advanced diabetic retinopathy. (2014) (59)
- Retinal GFAP and bFGF expression after multiple argon laser photocoagulation injuries assessed by both immunoreactivity and mRNA levels. (1997) (55)
- Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial. (2017) (53)
- Changes in murine hyalocytes are valuable early indicators of ocular disease. (2012) (53)
- Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model (2006) (50)
- Angiography reveals novel features of the retinal vasculature in healthy and diabetic mice. (2015) (50)
- Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides. (2002) (50)
- Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization. (2006) (48)
- Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates (2011) (48)
- Kinetic studies on phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro. (1994) (48)
- The effects of age and Cx3cr1 deficiency on retinal microglia in the Ins2(Akita) diabetic mouse. (2013) (46)
- Distribution of cathepsin D in human eyes with or without age-related maculopathy. (1999) (46)
- Detection and possible functions of a cysteine protease involved in digestion of rod outer segments by retinal pigment epithelial cells. (1994) (46)
- Expression of basic fibroblast growth factor and its receptor in the retina of Royal College of Surgeons rats. A comparative study. (1993) (45)
- Functional and structural evaluation after AAV.RPE65 gene transfer in the canine model of Leber's congenital amaurosis. (2003) (43)
- rAAV.sFlt-1 gene therapy achieves lasting reversal of retinal neovascularization in the absence of a strong immune response to the viral vector. (2009) (43)
- In vivo use of oligonucleotides to inhibit choroidal neovascularisation in the eye (2001) (41)
- Correlation between autofluorescent debris accumulation and the presence of partially processed forms of cathepsin D in cultured retinal pigment epithelial cells challenged with rod outer segments. (1996) (41)
- Gene transfer in the RPE65 null mutation dog: relationship between construct volume, visual behavior and electroretinographic (ERG) results (2003) (38)
- Absence of clinical correlates of diabetic retinopathy in the Ins2Akita retina (2013) (36)
- Three-year follow-up of Phase 1 and 2a rAAV.sFLT-1 subretinal gene therapy trials for exudative age related macular degeneration. (2019) (36)
- Enhanced recombinant adeno-associated virus-mediated vascular endothelial growth factor expression in the adult mouse retina: a potential model for diabetic retinopathy. (2003) (35)
- Gene Therapy for Age-Related Macular Degeneration (2016) (34)
- A simple flow cytometric technique to quantify rod outer segment phagocytosis in cultured retinal pigment epithelial cells. (1996) (34)
- Changes in retinal pigment epithelial cell autofluorescence and protein expression associated with phagocytosis of rod outer segments in vitro (1992) (34)
- Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. (2006) (33)
- Predilection of the macular region to high incidence of choroidal neovascularization after intense laser photocoagulation in the monkey. (2003) (32)
- Long‐term effect of therapeutic laser photocoagulation on gene expression in the eye (2006) (31)
- Eph/ephrin expression in the adult rat visual system following localized retinal lesions: localized and transneuronal up‐regulation in the retina and superior colliculus (2005) (27)
- Morphological aspects related to long-term functional improvement of the retina in the 4 years following rAAV-mediated gene transfer in the RPE65 null mutation dog. (2008) (27)
- Targeted delivery of an antisense oligonucleotide in the retina: uptake, distribution, stability, and effect. (1996) (27)
- The microarray: potential applications for ophthalmic research. (2002) (27)
- Inhibition of diclofenac formulated in hyaluronan on angiogenesis in vitro and its intraocular tolerance in the rabbit eye (2000) (27)
- Preclinical Evaluation of a Phosphorothioate Oligonucleotide in the Retina of Rhesus Monkey (2002) (26)
- Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice. (2005) (26)
- Influence of endotoxin-mediated retinal inflammation on phenotype of diabetic retinopathy in Ins2Akita mice (2013) (25)
- Human papillomavirus coinfections of the vulva and uterine cervix (1989) (23)
- Combined effect of cyclosporine and sirolimus on improving the longevity of recombinant adenovirus-mediated transgene expression in the retina. (2001) (23)
- Long‐term real‐time monitoring of adeno‐associated virus‐mediated gene expression in the rat retina (2000) (22)
- Expression of cathepsin S antisense transcripts by adenovirus in retinal pigment epithelial cells. (1998) (22)
- Adeno-associated virus-mediated vascular endothelial growth factor gene therapy in skeletal muscle before transplantation promotes revascularization of regenerating muscle. (2002) (20)
- In Vivo Monitoring of VEGF-Induced Retinal Damage in the Kimba Mouse Model of Retinal Neovascularization (2011) (19)
- VEGF-induced choroidal damage in a murine model of retinal neovascularisation (2008) (19)
- Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa (2014) (18)
- Dynamics of gene transfer to retinal pigment epithelium. (1996) (18)
- The Role of Vascular Endothelial Growth Factor (VEGF) in Abnormal Vascular Changes in the Adult Rat Eye (2000) (18)
- Synthetic Hydrogels as Carriers in Antisense Therapy: Preliminary Evaluation of an Oligodeoxynucleotide Covalent Conjugate with a Copolymer of 1-Vinyl-2-Pyrrolidinone and 2-Hydroxyethyl Methacrylate (2001) (18)
- The use of adenovirus-mediated gene transfer to develop a rat model for photoreceptor degeneration. (2000) (18)
- Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas (2017) (18)
- Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina (1999) (18)
- Uptake dynamics and retinal tolerance of phosphorothioate oligonucleotide and its direct delivery into the site of choroidal neovascularization through subretinal administration in the rat. (2001) (17)
- Detection of human papillomavirus type 16 DNA in cervical swabs and formalin-fixed, paraffin-embedded squamous cell carcinomas of non-genital tissues using a synthetic oligodeoxynucleotide probe. (1989) (17)
- Focusing on Sodium Glucose Cotransporter-2 and the Sympathetic Nervous System: Potential Impact in Diabetic Retinopathy (2018) (17)
- Biomarkers for Diabetic Retinopathy – Could Endothelin 2 Be Part of the Answer? (2016) (16)
- 13C NMR specta of 4‐quinolones and related compounds (1981) (16)
- A model for a blinding eye disease of the aged (2004) (16)
- Initiation of impaired outer segment degradation in vivo using an antisense oligonucleotide. (1996) (12)
- Correction: Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy (2013) (12)
- Laser photocoagulation: ocular research and therapy in diabetic retinopathy. (2006) (12)
- Antisense DNA technology. (2001) (11)
- Assessment of Local Functional Improvement following Gene Therapy in the RPE65 Null Mutation Dog Model (2003) (11)
- Development of gene therapy‐based strategies for the treatment of eye diseases (1999) (11)
- Assessment of rAAV-mediated gene therapy in the Rpe65-/- mouse. (2003) (10)
- Cell polarity, phagocytosis and viral gene transfer in cultured human retinal pigment epithelial cells. (1998) (10)
- Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice (2020) (10)
- Impurity of recombinant adeno-associated virus type 2 affects the transduction characteristics following subretinal injection in the rat (2004) (10)
- OVEREXPRESSION OF HEMOPEXIN IN THE DIABETIC EYE: A NEW PATHOGENIC CANDIDATE FOR DIABETIC MACULAR EDEMA (2013) (9)
- Cloning of a major human retinal pigment epithelial lysosomal aspartic protease and mapping its transcriptional start sites. (1999) (9)
- Characterisation of a model for retinal neovascularisation. VEGF model characterisation. (2006) (9)
- Preferential adenovirus-mediated transduction of cells at the sites of laser photocoagulation in the rat eye. (1999) (9)
- Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. (2007) (9)
- Detection of human papillomavirus DNA in cell scrapes and formalin‐fixed, paraffin‐embedded tissue of the uterine cervix by filter in situ hybridisation (1988) (9)
- Adeno-associated virus-mediated gene transfer into human retinal pigment epithelium cells. (1998) (8)
- Generation and characterization of a recombinant adenovirus expressing vascular endothelial growth factor for studies of neovascularization in the eye. (1999) (8)
- Gene therapy for eye as regenerative medicine? Lessons from RPE65 gene therapy for Leber's Congenital Amaurosis. (2014) (8)
- Addition of a c-myc epitope tag within the VEGF protein does not affect in vitro biological activity. (2001) (8)
- Kinetics of efficient recombinant adeno-associated virus transduction in retinal pigment epithelial cells. (2001) (8)
- Vision research protocols (2000) (7)
- Emerging biological therapies for age-related macula degeneration (2005) (7)
- Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization (2000) (7)
- Gene therapy for the long term treatment of wet AMD (2017) (7)
- Virus-mediated secretion gene therapy--a potential treatment for ocular neovascularization. (2003) (6)
- Contrasting actions of prolonged mitogen-activated protein kinase activation on cell survival. (2006) (6)
- Determining the role of SGLT2 inhibition with Empagliflozin in the development of diabetic retinopathy (2022) (6)
- Controlled production of active cathepsin D in retinal pigment epithelial cells following adenovirus-mediated gene delivery. (2000) (5)
- Discovery of a Novel Control Element within the 5′-Untranslated Region of the Vascular Endothelial Growth Factor (2004) (5)
- Entrainment of circadian rhythm to a photoperiod reversal shows retinal dystrophy in RPE65−/− mice (2003) (5)
- Detection of human papillomavirus in reprocessed routine papanicolaou smears by dna hybridization (1990) (5)
- Retinal cell responses to Argon Laser photocoagulation (1995) (4)
- Development and Evaluation of the Specificity of a Cathepsin D Proximal Promoter in the Eye (2005) (4)
- Pathogenesis of macular degeneration: is there any progress? (1998) (4)
- Pathological heterogeneity of vasoproliferative retinopathy in transgenic mice overexpressing vascular endothelial growth factor in photoreceptors. (2006) (4)
- An improved method using densitometry for evaluating severity of laser photocoagulation induced CNV (2006) (4)
- Recombinant adenovirus-mediated gene delivery into the rat retinal pigment epithelium in vivo. (1998) (4)
- Ocular gene therapy: the basic science and current state of research. (1997) (4)
- Concurrent enhancement of transcriptional activity and specificity of a retinal pigment epithelial cell-preferential promoter. (2004) (4)
- Discovery of a novel control element within the 5'UTR of VEGF: Regulation of expression using sense oligonucleotides. (2004) (3)
- Expression of transgenes in human and rat retinal pigment epithelium in vitro using an adenoviral vector. (1996) (3)
- Evaluation of AAV mediated gene trasfer into the rat retina by clinical fluorescent photography (1999) (3)
- Gene- and Cell-Based Treatment Strategies for the Eye (2015) (3)
- Regulation of tight junction proteins in cultured retinal pigment epithelial cells and in VEGF overexpressing transgenic mouse retinas. (2006) (3)
- A preliminary report on a DNA-based screening method for retinitis pigmentosa. A trial on a west Australian population. (1995) (2)
- Glial reactions to argon laser photocoagulation injury in rabbit and rat retinas (1996) (2)
- A novel immunoassay for the evaluation of rod outer segment digestion in cultured retinal pigment epithelial cells (2000) (2)
- Cloning of VEGF165 into expression vector for protein production. (1996) (2)
- HLA DQA tissue typing of cadaveric eye bank donor material with polymerase chain reaction. (1992) (2)
- Neovascular Age-Related Macular Degeneration: Secretion Gene Therapy (2015) (2)
- Partial recovery of retinal function and structure in RPE65-/- mice and dogs following rAAV - mediated gene therapy (2005) (1)
- Long–term modulation of gene expression in the mouse eye following laser photocoagulation (2004) (1)
- Age-Related Macular Degeneration: The Challenges (2015) (1)
- Gene transfer to human retinal pigment epithelial cells in vitro using an adenoviral vector (1995) (1)
- Simple modifications of clinical fundus cameras for retinal photography and angiography in small laboratory animals (2002) (1)
- Expression of cell adhesion molecules in experimental choroidal neovascularization in the rat (1998) (1)
- Anti-VEGF Gene Therapy for Wet AMD: Phase I/II Safety and Pharmacology Results (2013) (1)
- Gene Therapy in 6 Dogs With RPE65 Null Mutation Improves Visual Function: A Short-term Study Using Clinical Observations, Electrophysiology and Morphology (2002) (1)
- One Year Follow-Up Report on the rAAV.sFlt-1 Phase I Gene Therapy Trial for Exudative Age-Related Macular Degeneration (2014) (1)
- Cathepsin D Mutations Associated with Retinal Dystrophy in Transgenic Mice (2003) (1)
- Association of serum neutralizing antibodies with safety and efficacy outcomes in a Phase 2a trial of rAAV.sFlt-1 in the treatment of wet AMD (2016) (1)
- Long-term Ultrastructural Studies in RPE65-/- Dogs with and without Unilateral rAAV.RPE65 Gene Transfer Treatment (2003) (1)
- Quantifying rod outer segment phagocytosis and digestion and lipofuscin accumulation in cultured human RPE cells (1993) (1)
- Human retinal pigment epithelial cells in vitro: Quantification of rod outer segment phagocytosis and digestion, and lipofuscin accumulation (1993) (1)
- Phagocytosis and lysosomal digestion of rod outer segments by human retinal pigment epithelial cells in vitro (1993) (1)
- A Non-Invasive in vivo Assessment of the Akimba Mouse Eye (2010) (1)
- Potential use of cellular promoter(s) to target RPE in AAV-mediated delivery. Cellular promoters and RPE-targeting. (2006) (1)
- Controlling vascular endothelial growth factor: therapies for ocular diseases associated with neovascularization. (2006) (1)
- SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 5-SUBSTITUTED 6,7-METHYLENEDIOXY-4-QUINOLONE-3-CARBOXYLIC ACID DERIVATIVES (1979) (1)
- Uniform deletions of HPV16 DNA in the Caski cell line and in cervical carciomas; an analysis of the characteristics of integrated multimeric HPV16 genomes (1993) (1)
- 394. Baseline Data for Patients Participating in the Phase 2a rAAV.sFlt-1 Gene Therapy Trial for Exudative Age-Related Macular Degeneration (2015) (1)
- Use of Synthetic Dendrimer Peptide’s to Mediate the Delivery of a Sense Oligonucleotide (2003) (1)
- ASPECTS RELATED TO LONG-TERM FUNCTIONAL IMPROVEMENT OF THE RETINA IN THE 4 YEARS FOLLOWING rAAV-MEDIATED GENE TRANSFER IN THE RPE 65 NULL MUTATION DOG (1)
- Partial Denervation of the Superior Colliculus Induces Localised Up-regulation of Ephrin-A2 in the Adult Rat (2002) (1)
- 418. AAV-Mediated sFLT-1 Gene Therapy for Ocular Neovascularization: Longevity, Toxicity and Efficacy Results from Mice and Monkeys (2006) (1)
- Oligonucleotide gene therapy for choroidal neovascularisation enhanced by dendrimer mediated delivery (2003) (0)
- Autofluorescence induced by antisense DNA mediated inhibition of lysosomal enzymes (1994) (0)
- The Lessons of rAAV Mediated RPE65 Gene Delivery from Mouse and Dog Models of LCA (2003) (0)
- SOME ANOMALOUS REACTIONS OF 4-QUINOLONE-5-DIAZONIUM SALTS (1982) (0)
- Some anomalous reactions of 4‐quinolone‐5‐diazonium salts (1981) (0)
- Potential Use of Cathepsin D Proximal Promoter to Drive RPE-Specific Gene Expression (2003) (0)
- Preliminary report on the isolation of human RPE specific lysosomal enzyme clones (1993) (0)
- Construction of lysosomal enzyme expressions systems (1995) (0)
- 434. Long-Term Effects on Retinal Function and Structure Using AAV-Mediated Gene Therapy in Blind RPE65 Null Mutation Dogs (2005) (0)
- Boosting the Effects of Gene Therapy in RPE65 Null Mutation Dogs by Re–Treatment (2005) (0)
- Point mutations in the rhodopsin gene of Western Australian retinitis pigmentosa patients (1994) (0)
- Expression of Cathepsin S by adenovirus in retinal pigment epithelial cells (1998) (0)
- Is rAAV Mediated Upregulation of VEGF Sufficient to Induce a Neovascular Response in the Eye (2002) (0)
- One-year analysis of sFlt-1 and VEGF proteins and immunological markers in the bodily fluids of subjects participating in the Phase I rAAV.sFlt-1 trial. (2015) (0)
- 23rd Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec) (2013) (0)
- Antisense DNA mediated inhibition of lysosomal enzyme function in vivo (1995) (0)
- VEGF upregulation in retinal pigment epithelial cells (1996) (0)
- Cathepsin D upregulation in vitro (1997) (0)
- Characterization of the Akimba Mouse: A Diabetic Mouse With Ocular and Renal Changes (2008) (0)
- Histological changes in the rat retina following the upregulation of vegf expression by adenovirus mediated gene delivery (1998) (0)
- Cathepsin D or A cathepsin D-like enzyme in the retinal pigment epithelial cells (1994) (0)
- Isolation, sequencing and tissue distribution of a partial cathepsin D cDNA clone from human RPE cells. (1996) (0)
- Induction of photoreceptor derived debris accumulation in the retinal pigment epithelium (1996) (0)
- Development of an animal model for Age Related Macular Degeneration (2002) (0)
- Specific inhibition of lysosomal enzymes in human retinal pigment epithelial (HRPE) cells (1994) (0)
- Hyaluronan gene transfer to the retinal pigment epithelium of the eye. Prospects for treatment of subretinal neovascularization in age-related macular degeneration (1996) (0)
- Laser Induced Choroidal Neovascularization in a Mouse Model of Dry Age–related Macular Degeneration (2004) (0)
- Development of a Model for Macular Degeneration (1997) (0)
- Recombinant adenovirus-mediated transfer of genes into choridal neovascular membrane (1999) (0)
- Persistence of intravitreally injected cathepsin S antisense oligonucleotides (1995) (0)
- Cloning of VEGF165 into expression vector for antibody production (1995) (0)
- Combination of enhancing transcriptional activity and RPE–cell specificity improves transgene expression in RPE cells (2004) (0)
- Gene Therapy and Stem Cell Therapy: Overview (2015) (0)
- IDENTIFICATION OF GENES REGULATED BY ACCELERATED DEBRIS ACCUMULATION IN THE RETINAL PIGMENT EPITHELIAL CELLS OF THE MCD1 TRANSGENIC MOUSE (2004) (0)
- Rod outer segment digestion in cultured retinal pigment epithelium cells. The relationship between autofluorescent debris accumulation and different forms of cathepsin D (1996) (0)
- The role of cysteine proteases in the accumulation of lipofuscin within retinal pigment epithelial cells (1993) (0)
- Antisense DNA mediated manipulation of lysosomal enzymes (1995) (0)
- Microarray Analysis of Retinal Laser Photocoagulation (2002) (0)
- Ageing of the RPE development of a model (1995) (0)
- Determining the Role of SGLT2 Inhibition with Dapagliflozin in the Development of Diabetic Retinopathy. (2022) (0)
- Subanalysis of data from rAAV.sFLT-1 phase 1 and 2a randomized gene therapy trials for wet age-related macular degeneration. (2018) (0)
- Inhibition of Retinal Vascular Leakage in a Transgenic Vegf Mouse Model Following Intravitreal Bevacizumab (2007) (0)
- Transgenic mouse models with human diabetic retinopathy–like features (2004) (0)
- The Effect of SGLT2 Inhibition on Diabetic Kidney Disease in a Model of Diabetic Retinopathy (2022) (0)
- Sequencing and tissue distribution of a partial clone of lysosomal cathepsin D enzyme from a human RPE cDNA library (1995) (0)
- Ocular gene therapy - aspects of targeting the retinal pigment epithelium (1996) (0)
- The role of cathepsin D down regulation in ROS processing by RPE cells (1997) (0)
- Identification of the regulatory elements responsible for cathepsin D expression and activation in retinal pigment epithelium cells (1999) (0)
- Identification of mutations in patients with retinitis pigmentosa in beta subunit cGMPPDE (1994) (0)
- Cloning of human RPE specific lysosomal enzyme genes (1993) (0)
- Assessment of Endothelin-2 Expression in Hyperglycemic and Retinal Neovascularisation Mouse Models (2010) (0)
- Development Of Rat Models For Choroidal Neovascularisation (CNV) (1999) (0)
- Element regulateur de cathepsine d (2000) (0)
- In vitro and in vivo adeno-associated virus mediated gene transfer into RPE cells (1998) (0)
- Transfection and expression of mouse VEGF165 in a human retinal pigment epithelial cell line (1997) (0)
- Long-Term Upregulation of Endothelin-2 in a VEGF-Driven Mouse Model (trVEGF029) of Retinal Neovascularisation (RNV) (2008) (0)
- Genetic Vaccines and Therapy (2004) (0)
- Identification of a New Angiogenesis Associated Gene in the Retina (2007) (0)
- Longevity and Toxicity of AAV–Mediated sFLT–1 Gene Therapy for Ocular Neovascularization in Mice and Monkeys (2006) (0)
- Anti-VEGF Gene Therapy for Wet AMD: Safety and Tolerability of Subretinal Delivery in a Phase I/II Clinical Trial (2013) (0)
- Development and Implementation of an ELISA to Detect “Anti- Ranibizumab” Immunity in Age-Related Macular Degeneration Patients (2013) (0)
- Comparison of Adenovirus and Adeno-Associated virus mediated gene transfer into the rat tetina-efficiency and theirintraocular tolerance (1999) (0)
- Correlation Between Protein Stability And Retinitis Pigmentosa (2010) (0)
- The Response of the Retina to Systemic Inflammatory Stimuli in a Model of Background Non-Proliferative Diabetic Retinopathy (2010) (0)
- Safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration following a phase 2a randomized clinical trial (2017) (0)
- The Potential Of Marrow Stromal Cells (msc) In The Treatment Of Ocular Disease (2002) (0)
- Construction of a cDNA library from human retinal pigment epithelial cells challenged with rod outer segments. (1995) (0)
- The results of establishing a regional Eye Bank (1992) (0)
- Traitement de la néovascularisation excessive (2007) (0)
- CHARACTERIZATION OF NEOVASCULAR RESPONSES IN TRANSGENIC MICE WITH TISSUE–SPECIFIC OVEREXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (2004) (0)
- Lipid and carbohydrate based macromolecules in drug and vaccine delivery (2003) (0)
- Synthesis of cationic lipidic peptide dendrimer vectors for in vitro oligonucleotide delivery. (2001) (0)
- The effect of antisense-mediated inhibition of a new cathepsin type enzyme on rod outer segment digestion by human retinal pigment epithelial (HRPE) cells (1993) (0)
- Comparing and Contrasting the Effects of the SGLT Inhibitors Canagliflozin and Empagliflozin on the Progression of Retinopathy. (2023) (0)
- Preclinical Evaluation of rAAV.sFlt-1 in Monkeys: Toxicity and Biodistribution (2008) (0)
- Human adipose stem cell derived pericytes protect against retinal vasculopathy in vivo (2013) (0)
- Retinal and Choroidal Vascular Changes in VEGF Transgenic Models of Retinal Neovascularisation (2007) (0)
- The role of cellular orientation in gene transfer to the RPE (1997) (0)
- Combined SGLT1 and 2 Inhibition Os Associated With Improved Glucose Control and Multi-Organ Protection in the Type 1 Diabetic Akimba Mouse (2022) (0)
- Long-term Visual Behavior Correlates with Functional Electroretinographic Assessment after Gene Transfer in RPE65-/- Dogs (2003) (0)
- Kinetics of rod outer segment processing by human RPE in vitro (1993) (0)
- 248. Results of a Phase 1 and 2a Trial on rAAV. sFlt-1 in Treatment of Wet Age-Related Macular Degeneration (2016) (0)
- Development of an animal model for eye diseases induced by debris accumulation in the Retinal Pigment Epithelial cells (1995) (0)
- Animal Model Progressive Age-Related Changes Similar to Age-Related Macular Degeneration in a Transgenic Mouse Model (2002) (0)
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