Elizabeth Robertson
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British geneticist
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Why Is Elizabeth Robertson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Elizabeth Jane Robertson is a British developmental biologist based at the Sir William Dunn School of Pathology, University of Oxford. She is Professor of Developmental Biology at Oxford and a Wellcome Trust Principal Research Fellow. She is best known for her pioneering work in developmental genetics, showing that genetic mutations could be introduced into the mouse germ line by using genetically altered embryonic stem cells. This discovery opened up a major field of experimentation for biologists and clinicians.
Elizabeth Robertson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) (1993) (2981)
- Role of insulin-like growth factors in embryonic and postnatal growth (1993) (2384)
- Parental imprinting of the mouse insulin-like growth factor II gene (1991) (1810)
- Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines (1984) (1554)
- Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 (1991) (1313)
- Teratocarcinomas and embryonic stem cells : a practical approach (1987) (1240)
- A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. (1995) (1170)
- A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. (1994) (834)
- Axis Development and Early Asymmetry in Mammals (1999) (763)
- Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector (1986) (754)
- Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection (2012) (705)
- Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo (2009) (701)
- An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. (1989) (591)
- Relationship between asymmetric nodal expression and the direction of embryonic turning (1996) (579)
- Nodal signalling in the epiblast patterns the early mouse embryo (2001) (537)
- Pitx2 determines left–right asymmetry of internal organs in vertebrates (1998) (530)
- An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation (2007) (512)
- A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice (1987) (492)
- Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo (1998) (489)
- Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos (1997) (476)
- Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development (1995) (454)
- Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. (2001) (419)
- nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. (1997) (418)
- Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. (1999) (404)
- Mice lacking Bmp6 function. (1998) (388)
- Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. (1999) (374)
- Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. (2002) (373)
- Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression (1993) (358)
- The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse (2005) (346)
- Pluripotency factors regulate definitive endoderm specification through eomesodermin. (2011) (335)
- The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo. (1991) (332)
- Cell fate decisions within the mouse organizer are governed by graded Nodal signals. (2003) (331)
- Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. (1993) (328)
- Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. (1992) (324)
- Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases (1999) (318)
- The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. (2008) (312)
- The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. (2006) (308)
- Anterior patterning in mouse. (1998) (308)
- Mice homozygous for the abl m1 mutation show poor viability and depletion of selected B and T cell populations (1991) (305)
- Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. (1998) (305)
- XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. (1990) (304)
- Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme. (1999) (298)
- Nodal activity in the node governs left-right asymmetry. (2002) (290)
- BMP7 acts in murine lens placode development. (1999) (284)
- Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. (1989) (284)
- The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. (2002) (244)
- From fertilization to gastrulation: axis formation in the mouse embryo. (2001) (240)
- Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. (2001) (226)
- The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation (2011) (222)
- X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation. (1985) (221)
- Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse (2008) (220)
- Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo (2004) (215)
- Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. (1993) (209)
- Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice (2007) (208)
- Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. (2012) (203)
- SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. (2000) (195)
- Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. (1999) (193)
- Establishment of pluripotential cell lines from haploid mouse embryos. (1983) (190)
- Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene. (1993) (190)
- Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo (2004) (178)
- Formation of the definitive endoderm in mouse is a Smad2-dependent process. (2000) (172)
- Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. (2006) (171)
- Regulation of BMP7 expression during kidney development. (1998) (160)
- Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. (2006) (148)
- A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. (1991) (147)
- Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes. (1993) (143)
- Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain (2014) (141)
- arc6, A Fertile Arabidopsis Mutant with Only Two Mesophyll Cell Chloroplasts (1994) (134)
- Synthesis of medium-chain-length polyhydroxyalkanoates in arabidopsis thaliana using intermediates of peroxisomal fatty acid beta-oxidation. (1998) (133)
- Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. (1995) (125)
- Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice (2007) (124)
- Using embryonic stem cells to introduce mutations into the mouse germ line. (1991) (119)
- The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes (2011) (115)
- TGFβ superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population (2004) (109)
- The distinctive roles of five different ARC genes in the chloroplast division process in Arabidopsis. (1999) (108)
- SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis (1996) (104)
- Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development (2011) (102)
- Dose-dependent Nodal/Smad signals pattern the early mouse embryo. (2014) (101)
- An expanding job description for Blimp-1/PRDM1. (2009) (100)
- Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. (2000) (100)
- X-chromosome instability in pluripotential stem cell lines derived from parthenogenetic embryos. (1983) (96)
- The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development (1994) (96)
- arc6, an extreme chloroplast division mutant of Arabidopsis also alters proplastid proliferation and morphology in shoot and root apices. (1995) (95)
- Pluripotential stem cell lines as a route into the mouse germ line (1986) (94)
- Characterization of Chloroplast Division Using the Arabidopsis Mutant arc5 (1996) (93)
- Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. (2005) (90)
- Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta. (1990) (90)
- Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. (2004) (89)
- Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function (2008) (88)
- Role of BMP family members during kidney development. (1999) (80)
- Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development. (1991) (75)
- Response of the photosynthetic apparatus in maize leaves grown at low temperature on transfer to normal growth temperature (1995) (72)
- Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. (2003) (71)
- Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy (2016) (70)
- Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development (2015) (69)
- BMP4 substitutes for loss of BMP7 during kidney development. (2005) (69)
- BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. (2008) (69)
- High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination (1990) (66)
- Significant Changes in Cell and Chloroplast Development in Young Wheat Leaves (Triticum aestivum cv Hereward) Grown in Elevated CO2 (1995) (66)
- Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein. (1990) (66)
- Left-Right Asymmetry (1997) (64)
- The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. (2013) (63)
- Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. (2008) (63)
- MHC class I surface expression in embryo-derived cell lines inducible with peptide or interferon (1991) (62)
- Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. (2012) (60)
- Blimp-1/Prdm1 Alternative Promoter Usage during Mouse Development and Plasma Cell Differentiation (2009) (59)
- Identification of novel protein kinases expressed in the myocardium of the developing mouse heart (1994) (58)
- Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development (2009) (56)
- The murine LIM-kinase gene (limk) encodes a novel serine threonine kinase expressed predominantly in trophoblast giant cells and the developing nervous system (1995) (54)
- Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis. (2011) (54)
- Mitochondria Increase Three-Fold and Mitochondrial Proteins and Lipid Change Dramatically in Postmeristematic Cells in Young Wheat Leaves Grown in Elevated CO2 (1995) (51)
- Chloroplast thylakoid protein changes induced by low growth temperature in maize revealed by immunocytology (1993) (51)
- DM Loss in k Haplotype Mice Reveals Isotype-Specific Chaperone Requirements 1 (2003) (49)
- Nodal signaling and axis formation in the mouse. (1997) (47)
- The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis (2011) (47)
- A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response (2012) (47)
- Experimental approaches to mammalian embryonic development: Production of permanent cell lines from early embryos and their use in studying developmental problems (1987) (45)
- Embryo-derived stem cells: a tool for elucidating the developmental genetics of the mouse. (1986) (44)
- Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain. (1995) (41)
- Relaxed DM Requirements During Class II Peptide Loading and CD4+ T Cell Maturation in BALB/c Mice1 (2001) (41)
- Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping, and in situ hybridization. (1990) (40)
- Effects of the TWis mutation on notochord formation and mesodermal patterning (1995) (40)
- Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts. (1997) (38)
- Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements (2004) (37)
- Highly efficient transgene‐independent recombination directed by a maternally derived SOX2CRE transgene (2003) (36)
- Tissue-specific expression of the human type II collagen gene in mice. (1987) (36)
- Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off (1991) (36)
- Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo (2017) (34)
- Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation (2015) (33)
- Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes (2013) (32)
- Derivation and maintenance of embryonic stem cell cultures. (1997) (31)
- No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. (2002) (30)
- Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life (2017) (29)
- Derivation and maintenance of embryonic stem cell cultures. (1990) (28)
- Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming (2018) (28)
- Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney (2002) (27)
- Transformation of embryonic stem cells with the human type-II collagen gene and its expression in chimeric mice. (1985) (26)
- The ability of EK cells to form chimeras after selection of clones in G418 and some observations on the integration of retroviral vector proviral DNA into EK cells. (1985) (26)
- Efficient gene-specific expression of Cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci (1999) (25)
- The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo (2013) (24)
- Defective assembly of class I major histocompatibility complex molecules in an embryonic cell line (1991) (24)
- Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens. (1992) (23)
- Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse (2019) (23)
- The Nonconventional MHC Class II Molecule DM Governs Diabetes Susceptibility in NOD Mice (2013) (23)
- In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain. (1997) (21)
- Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. (2007) (20)
- Left-right asymmetry in vertebrates. (1997) (20)
- The mouse frizzled 8 receptor is expressed in anterior organizer tissues. (2004) (19)
- Keeping a lid on nodal: transcriptional and translational repression of nodal signalling (2016) (19)
- Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation (2017) (17)
- Use of embryonic stem cells to study mutations affecting postimplantation development in the mouse. (1992) (17)
- Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. (2007) (17)
- Alternative Splicing Regulates Prdm1/Blimp-1 DNA Binding Activities and Corepressor Interactions (2012) (16)
- Lipid metabolism in leaves from young wheat (Triticum aestivum cv. Hereward) plants grown at two carbon dioxide levels (1998) (16)
- Influence of injected pluripotential (EK) cells on haploid and diploid parthenogenetic development. (1984) (15)
- Targeted insertion of an IRES Cre into the Hnf4α locus: Cre‐mediated recombination in the liver, kidney, and gut epithelium (2004) (14)
- The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice (2020) (12)
- The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development (2016) (12)
- Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells (2018) (12)
- Formation of the definitive endoderm is a Smad2-dependent process (2000) (11)
- Importance of sequences adjacent to the terminal tripeptide in the import of a peroxisomal Candida tropicalis protein in plant peroxisomes (2000) (11)
- Insulin-like growth factors, imprinting and embryonic growth control (1995) (11)
- The transcriptional repressor Blimp 1 is expressed in rare luminal progenitors and is essential for mammary gland development (2016) (8)
- The effects of elevated atmospheric CO2 on lipid metabolism in leaves from mature wheat (Triticum aestivum cv. Hereward) plants (1998) (8)
- TGF beta signaling pathways controlling polarity of the early mouse embryo. (2000) (7)
- The T-box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk-Sac Mesodermal Progenitors (2021) (6)
- Cell-Cell Signaling in Vertebrate Development (1993) (6)
- One PRDM is not enough for germ cell development (2008) (6)
- Low Level of Hoxl.3 Gene Expression Does Not Preclude the Use of Promoterless Vectors To Generate a Targeted Gene Disruptiont (4)
- Erratum: Efficient gene-specific expression of Cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci (Mechanisms of Development 85 (1999) (35-47) PII: S0925477399000520) (1999) (3)
- Summary Differential requirements for Smad 4 in TGF β-dependent patterning of the early mouse embryo (2)
- Experimental pathology - 2 (2009) (2)
- Publisher Correction: Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy (2018) (1)
- Embryonic lethality in mice homozygous for a targeted disruption of References (2007) (1)
- Making heads and tails of the early mouse embryo. (2005) (1)
- Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse (2018) (1)
- The expression of a soluble 14.5 Kdal ß-galactosine binding lectin is regulated during mouse embryogenesis (1989) (1)
- Publisher Correction: The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors (2021) (1)
- Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life (2017) (1)
- Maturation in BALB/c Mice Peptide Loading and CD4+ T Cell Relaxed DM Requirements During Class II (2013) (0)
- A possible role of prolactin in preventing heartburn during pregnancy. (1979) (0)
- The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice (2020) (0)
- Pathways controlling cell fate decisions in the early mouse embryo (2009) (0)
- Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation (2017) (0)
- Developmental Regulation of MHC Class I Gene Expression in Mice (1994) (0)
- Author index (1995) (0)
- Isotype-Specific Chaperone Requirements DM Loss in k Haplotype Mice Reveals (2013) (0)
- Methods and vector constructs for the generation of transgenic rodents expressing a heterologous gen ubiquitously (1999) (0)
- No Effects of Smad2 ( Madh2 ) Null Mutation on Malignant Progression of Intestinal Polyps in Apc (cid:1) 716 Knockout Mice 1 (2002) (0)
- Axis Development and Early Review Asymmetry in Mammals (1999) (0)
- Transcriptional networks regulating cell allocation in the post-implantation mouse embryo (2017) (0)
- The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors (2021) (0)
- 2018 – EOMESODERMIN GOVERNS THE HEMOGENIC COMPETENCE OF MURINE YOLK-SAC MESODERMAL PROGENITORS (2020) (0)
- Developmental failure ofchimeric embryos expressing highlevels ofH-2Ddtransplantation antigens (1992) (0)
- Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells (2018) (0)
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