Elizabeth A. Winzeler
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Elizabeth A. Winzelerchemistry Degrees
Chemistry
#4180
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#5245
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#887
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Organic Chemistry
#674
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#769
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#115
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Elizabeth A. Winzelerbiology Degrees
Biology
#10135
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#13434
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#2481
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Computational Biology
#244
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#245
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#37
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Biochemistry
#1847
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#1987
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#294
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Chemistry Biology
Elizabeth A. Winzeler's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, San Diego
Why Is Elizabeth A. Winzeler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Elizabeth Ann Winzeler is an American microbiologist and geneticist. She is a professor in the Division of Host-Microbe Systems and Therapeutics of the School of Medicine at the University of California at San Diego. Although she works in a variety of different disease areas, most research focuses on developing better medicines for the treatment and eradication of malaria.
Elizabeth A. Winzeler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Functional profiling of the Saccharomyces cerevisiae genome (2002) (4225)
- Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. (1999) (4002)
- A genome-wide transcriptional analysis of the mitotic cell cycle. (1998) (2299)
- Genomics, gene expression and DNA arrays (2000) (2077)
- Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle (2003) (1252)
- Spiroindolones, a Potent Compound Class for the Treatment of Malaria (2010) (983)
- Replication dynamics of the yeast genome. (2001) (848)
- Genomic profiling of drug sensitivities via induced haploinsufficiency (1999) (535)
- Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. (2004) (457)
- The core meiotic transcriptome in budding yeasts (2000) (454)
- In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen (2008) (423)
- Large-scale identification of single-feature polymorphisms in complex genomes. (2003) (390)
- Direct allelic variation scanning of the yeast genome. (1998) (378)
- Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria (2010) (361)
- Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae (2003) (358)
- The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites (2012) (351)
- The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. (2005) (348)
- Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016) (324)
- Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016) (324)
- Targeting Plasmodium PI(4)K to eliminate malaria (2013) (322)
- A novel multiple-stage antimalarial agent that inhibits protein synthesis (2015) (315)
- Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery (2011) (307)
- A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes (2010) (287)
- Molecular Mechanism for Switching of P. falciparum Invasion Pathways into Human Erythrocytes (2005) (285)
- Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent (2012) (254)
- Distinct physiological states of Plasmodium falciparum in malaria-infected patients (2007) (246)
- Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. (2008) (220)
- First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. (2010) (219)
- Plasmodium Circumsporozoite Protein Promotes the Development of the Liver Stages of the Parasite (2007) (217)
- A Systematic Map of Genetic Variation in Plasmodium falciparum (2006) (204)
- Na+ Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials (2013) (202)
- malERA: An updated research agenda for malaria elimination and eradication (2017) (198)
- Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin (2012) (194)
- Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. (2003) (191)
- Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (2016) (190)
- Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families (2013) (178)
- Antimalarial drug discovery — approaches and progress towards new medicines (2013) (164)
- Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics (2017) (161)
- A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. (2004) (157)
- Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection (2018) (137)
- Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum (2009) (135)
- The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands (2010) (135)
- Validation of isoleucine utilization targets in Plasmodium falciparum (2011) (127)
- Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast (2002) (127)
- High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission (2016) (125)
- In silico discovery of transcription regulatory elements in Plasmodium falciparum (2008) (123)
- The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast (2002) (122)
- KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission (2014) (119)
- In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. (2005) (114)
- Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites (2011) (114)
- Exploiting the divergent reactivity of aryl-palladium intermediates for the rapid assembly of fluorene and phenanthrene derivatives. (2009) (107)
- Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes (2010) (101)
- Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents (2011) (99)
- Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum (2002) (97)
- Antimalarial drug discovery — approaches and progress towards new medicines (2017) (96)
- UDP-galactose and Acetyl-CoA transporters as Plasmodium multidrug resistance genes (2016) (95)
- A broad analysis of resistance development in the malaria parasite (2016) (94)
- A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito (2010) (94)
- Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimal (2012) (92)
- Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design (2012) (92)
- In silico gene function prediction using ontology-based pattern identification (2005) (91)
- Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents (2012) (89)
- A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine (2017) (88)
- A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor (2011) (87)
- Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes (2009) (84)
- Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. (2013) (84)
- Treasures and traps in genome-wide data sets: case examples from yeast (2002) (84)
- Evidence-Based Annotation of the Malaria Parasite's Genome Using Comparative Expression Profiling (2008) (84)
- Open-source discovery of chemical leads for next-generation chemoprotective antimalarials (2018) (83)
- Drug resistance genomics of the antimalarial drug artemisinin (2014) (77)
- Application of High-Density Array-Based Signature-Tagged Mutagenesis To Discover Novel YersiniaVirulence-Associated Genes (2001) (76)
- Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials (2014) (76)
- Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study (2018) (75)
- A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum (2008) (75)
- High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria (2016) (73)
- Malaria research in the post-genomic era (2008) (72)
- Parallel identification of new genes in Saccharomyces cerevisiae. (2002) (71)
- Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (2019) (70)
- A high throughput screen for next-generation leads targeting malaria parasite transmission (2018) (70)
- Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. (2011) (70)
- A High Resolution Case Study of a Patient with Recurrent Plasmodium vivax Infections Shows That Relapses Were Caused by Meiotic Siblings (2014) (70)
- Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles (2015) (70)
- A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles. (2008) (69)
- Synthesis of annulated 2H-indazoles and 1,2,3- and 1,2,4-triazoles via a one-pot palladium-catalyzed alkylation/direct arylation reaction. (2008) (69)
- Resolution of [4]heterohelicenium dyes with unprecedented Pummerer-like chemistry. (2005) (68)
- KAI407, a Potent Non-8-Aminoquinoline Compound That Kills Plasmodium cynomolgi Early Dormant Liver Stage Parasites In Vitro (2013) (64)
- Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. (2014) (64)
- Using genetic methods to define the targets of compounds with antimalarial activity. (2013) (64)
- Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. (2010) (62)
- Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm (2016) (62)
- Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria (2013) (62)
- Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. (2007) (61)
- Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity (2017) (60)
- Direct transfer of whole genomes from bacteria to yeast (2013) (60)
- In vivo transcriptional profiling of Plasmodium falciparum (2004) (59)
- The paradoxical population genetics of Plasmodium falciparum. (2002) (58)
- Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. (2002) (56)
- Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity. (2007) (55)
- Whole genome genetic-typing in yeast using high-density oligonucleotide arrays (1999) (54)
- CRISPR‐Cas9‐modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs (2016) (54)
- Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays. (2005) (54)
- Functional analysis of the yeast genome. (1997) (53)
- Mechanisms of gene regulation in Plasmodium. (2007) (52)
- Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates (2017) (52)
- Fluorescence-based expression monitoring using microarrays. (1999) (51)
- Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy (2016) (50)
- Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples (2017) (50)
- Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery (2018) (50)
- Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome (2018) (49)
- Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target (2018) (48)
- Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections (2019) (46)
- Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery (2019) (46)
- The genomic architecture of antimalarial drug resistance (2019) (45)
- Whole genome sequencing analysis of Plasmodium vivax using whole genome capture (2012) (45)
- Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity (2020) (45)
- Infection of Laboratory-Colonized Anopheles darlingi Mosquitoes by Plasmodium vivax (2014) (45)
- Identification of pathogen genomic variants through an integrated pipeline (2014) (44)
- Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class. (2016) (43)
- Applied systems biology and malaria (2006) (42)
- The development process for discovery and clinical advancement of modern antimalarials. (2019) (42)
- Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance (2016) (41)
- Phenotypic Screens in Antimalarial Drug Discovery. (2016) (41)
- Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis (2018) (41)
- Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box (2020) (41)
- Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. (2016) (41)
- Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents (2019) (41)
- Target identification and validation of novel antimalarials. (2011) (41)
- Use of flow cytometry to identify a Caulobacter 4.5 S RNA temperature-sensitive mutant defective in the cell cycle. (1995) (41)
- New Ru Nanoparticles Stabilized by Organosilane Fragments (2004) (40)
- Pummerer fragmentation vs. pummerer rearrangement: a mechanistic analysis. (2006) (40)
- Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. (2007) (39)
- Large-Scale Annotation of Small-Molecule Libraries Using Public Databases (2007) (38)
- Chiral selectivity in the binding of [4]helicene derivatives to double-stranded DNA. (2013) (37)
- Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor (2016) (37)
- MalDA, Accelerating Malaria Drug Discovery (2021) (36)
- Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. (2004) (36)
- Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection (2019) (35)
- Excited-state properties of chiral [4]helicene cations. (2012) (34)
- Esterase mutation is a mechanism of resistance to antimalarial compounds (2017) (33)
- A key role for lipoic acid synthesis during Plasmodium liver stage development (2013) (33)
- Antimalarial drug discovery — approaches and progress towards new medicines (2013) (33)
- Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes (2016) (30)
- Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays (2004) (30)
- Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity (2017) (30)
- Genomics, systems biology and drug development for infectious diseases. (2007) (30)
- Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. (2015) (29)
- Effective HPLC resolution of [4]heterohelicenium dyes on chiral stationary phases using reversed-phase eluents. (2007) (29)
- Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. (2014) (28)
- Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival (2010) (28)
- In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum. (2017) (27)
- Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii (2019) (27)
- A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines. (2015) (27)
- One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. (2018) (27)
- The antimalarial resistome – finding new drug targets and their modes of action (2020) (26)
- Large-scale mutagenesis and functional genomics in yeast (2002) (25)
- Trimesitylmethylphosphonium cation. Supramolecular stereocontrol and simple enantiomerization mechanism determination. (2006) (25)
- Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma (2018) (25)
- Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. (2017) (25)
- Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. (2012) (25)
- Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. (2005) (24)
- Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites (2018) (23)
- Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria (2013) (23)
- Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus (2017) (23)
- Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling (2015) (22)
- Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. (2011) (22)
- Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. (2010) (22)
- Systems analysis of host–parasite interactions (2015) (21)
- Structure–Activity and Structure–Toxicity Relationships of Peptoid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Antiplasmodial Activity (2019) (21)
- Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing (2018) (21)
- In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model (2019) (20)
- Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention (2021) (19)
- Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization. (2000) (19)
- Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni (2018) (18)
- Translation of the leaderless Caulobacter dnaX mRNA (1997) (18)
- Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box. (2018) (18)
- Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities. (2016) (17)
- Screening of the ‘Stasis Box’ identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus (2017) (17)
- Bent structure and dynamic stereochemistry of chiral acridinium cations. (2003) (17)
- A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes. (1996) (17)
- Cell-based optimization of novel benzamides as potential antimalarial leads (2009) (16)
- Elucidating genetic diversity with oligonucleotide arrays (2005) (16)
- Exploiting the Divergent Reactivity of Aryl—Palladium Intermediates for the Rapid Assembly of Fluorene and Phenanthrene Derivatives. (2009) (16)
- Tris(2,4,6-trimethoxyphenyl)methyl carbenium ion for charge derivatization of amines and amino acids. (2008) (15)
- Targeted Disruption of a Ring-infected Erythrocyte Surface Antigen (RESA)-like Export Protein Gene in Plasmodium falciparum Confers Stable Chondroitin 4-Sulfate Cytoadherence Capacity* (2014) (15)
- Genomics and systems biology in malaria drug discovery. (2010) (15)
- Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway (2019) (15)
- Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases (2020) (15)
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 (2013) (14)
- Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials (2020) (14)
- Prioritization of Molecular Targets for Antimalarial Drug Discovery (2021) (13)
- Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites (2020) (13)
- Epidemiology: Resistance mapping in malaria (2013) (13)
- malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication (2017) (13)
- Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. (2021) (12)
- Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. (2021) (12)
- Exploration of the Plasmodium falciparum Resistome and Druggable Genome Reveals New Mechanisms of Drug Resistance and Antimalarial Targets (2018) (12)
- Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome (2021) (11)
- Vicinal diphosphoniums: electrostatic repulsion under covalent constraint. (2009) (11)
- Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites (2021) (11)
- Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon (2018) (11)
- Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. (2020) (11)
- Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum (2011) (11)
- Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. (2020) (11)
- Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus (2021) (11)
- PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum (2021) (10)
- Fluorescence anisotropy decay of ethidium bound to nucleosome core particles. 2. The torsional motion of the DNA is highly constrained and sensitive to pH. (1991) (10)
- Perspectives: The missing pieces (2012) (10)
- Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy (2022) (10)
- Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins during in vitro Culture Attenuation (2016) (10)
- Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents. (2018) (10)
- Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials (2016) (9)
- Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development (2022) (9)
- Actives from MMV Open Access Boxes? A suggested way forward (2021) (9)
- Susceptibility Testing of Medically Important Parasites (2017) (9)
- The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance (2021) (9)
- Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. (2021) (9)
- Design and Synthesis of Terephthalic Acid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Anti‐Plasmodium Activity (2017) (9)
- The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance (2021) (9)
- In vivo profiles in malaria are consistent with a novel physiological state (2009) (8)
- Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors (2021) (8)
- Plasmodium Circumsporozoite Protein Promotes the Development of the Liver Stages of the Parasite (2008) (8)
- Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection (2017) (8)
- Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis (2016) (8)
- Genomic Approaches to Drug Resistance in Malaria. (2020) (8)
- Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region. (2018) (8)
- Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone (2019) (7)
- Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives. (2020) (7)
- A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites. (2020) (6)
- Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype. (1997) (6)
- Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity. (2021) (6)
- Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone (2019) (6)
- Aneuploidy—it's more common than you think (2000) (5)
- Using the genome to dissect the molecular basis of drug resistance. (2006) (5)
- The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa (2019) (5)
- Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. (2021) (5)
- A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum (2022) (5)
- Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity. (2020) (5)
- Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum (2022) (4)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (4)
- Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2 (2022) (4)
- 8‐Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual‐Stage Antiplasmodial Activity (2019) (4)
- 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. (2017) (4)
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 (2013) (4)
- The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages (2022) (4)
- Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2 (2022) (4)
- Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance (2022) (4)
- Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. (2021) (3)
- A roadmap for malaria research (2019) (3)
- Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum. (2021) (3)
- The Transcriptome of the Malaria Parasite Plasmodium falciparum (2005) (3)
- The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides (2020) (3)
- Analysis of the Meiotic Transcriptome in Genetically Distinct Budding Yeasts Using High Density Oligonucleotide Arrays (2000) (3)
- In vivo transcriptional profiling of P . falciparum (2004) (3)
- Advances in Parasite Genomics: From Sequences to Regulatory Networks (2009) (3)
- Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing (2021) (3)
- Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty (2020) (3)
- Large‐Scale Annotation of Small‐Molecule Libraries Using Public Databases. (2007) (2)
- A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays. (2005) (2)
- Editorial OverviewTechniques: Editorial overview: Genome-wide approaches to cell function (2000) (2)
- Piperaquine Resistance is Associated with a Copy Number Variation on 1 (2011) (2)
- Failure of in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes arises because of poor gamete fertilisation (2017) (2)
- Glycophorin alleles link to malaria protection (2017) (2)
- Dual RNAseq shows the human mucosal immunity protein, MUC13, is a hallmark of Plasmodium exoerythrocytic infection (2017) (2)
- A small-molecule myosin inhibitor as a targeted multi-stage antimalarial (2022) (2)
- Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases (2021) (2)
- A Sleeping Area of Malaria Research Awakes. (2018) (2)
- Substituted Aminoacetamides as Novel Leads for Malaria Treatment (2019) (2)
- Coordinated functions of WSS 1 , PSY 2 and TOF 1 in the DNA damage response (2004) (2)
- Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis (2018) (2)
- Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out (2022) (2)
- Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 (2022) (2)
- A small-molecule myosin inhibitor as a targeted multi-stage antimalarial (2022) (2)
- Using in vitro evolution and whole genome analysis (IVIEWGA) to identify targets of antiparasitic compounds (2019) (1)
- Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer (2022) (1)
- Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance (2017) (1)
- A high throughput screen for next-generation leads targeting malaria parasite transmission (2018) (1)
- Identification of pathogen genomic variants through an integrated pipeline (2014) (1)
- Development of Potent and Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors. (2023) (1)
- Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus (2017) (1)
- Biochips in Malaria for Antiparasitic Discovery (2006) (1)
- IDENTIFYING HEXAHYDROQUINOLINES AS NEW ANTIMALARIALS WITH POTENT BLOOD STAGE AND TRANSMISSION-BLOCKING ACTIVITY (2017) (1)
- SnapShot: Antimalarial Drugs (2020) (1)
- IDENTIFICATION OF THE PLASMODIUM FALCIPARUM ACETYL-COA SYNTHETASE AS AN EMERGING ANTIPLASMODIAL DRUG TARGET (2019) (1)
- Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing (2018) (1)
- Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target (2023) (1)
- Screening of the ‘Stasis Box’ identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus (2017) (1)
- Drug resistance genomics of the antimalarial drug artemisinin (2014) (1)
- Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases (2020) (1)
- Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei (2022) (1)
- Mining High‐Throughput Screening Data by Novel Knowledge‐Based Optimization Analysis (2009) (1)
- Meister Antimalarial Drug Discovery Liver Stages to Drive Next-Generation Plasmodium Imaging of (2012) (0)
- Pan-active imidazolopiperazine antimalarials target the falciparum intracellular secretory pathway. (2020) (0)
- 1 Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum 2 intracellular secretory pathway 3 (2019) (0)
- Systems biology and malaria (2004) (0)
- CCDC 1045853: Experimental Crystal Structure Determination (2017) (0)
- A Palladium‐Catalyzed Alkyation/Direct Arylation Synthesis of Nitrogen‐Containing Heterocycles. (2008) (0)
- Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation (2016) (0)
- Rudimentary Structure-Activity-Relationship study of the MMV Pathogen Box compound MMV675968 (2,4-diaminoquinazoline) unveils novel inhibitors of Trypanosoma brucei brucei DHFR enzyme (2022) (0)
- Targeting Plasmodium phosphatidylinositol-4 kinase for the treatment, prevention and elimination of malaria (2013) (0)
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation (2023) (0)
- A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL) (2022) (0)
- Evidence for mitotic recombination in the sub‐telomeric regions of the Plasmodium falciparum genome, with implications for malaria virulence (1050.8) (2014) (0)
- through the of as (2018) (0)
- Current Pipeline of Antimalarial Therapies (2017) (0)
- Whole genome sequencing analysis of Plasmodium vivax using whole genome capture BMC Genomics (2019) (0)
- Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection (2019) (0)
- Development of high-density DNA array based signature-tagged mutagenesis and its application for the discovery of novel Y. pseudotuberculosis virulence-associated genes (2000) (0)
- Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in Toxoplasma gondii (2019) (0)
- IDENTIFICATION OF A DUAL LIVER-ASEXUAL STAGE ANTIMALARIAL TARGETING PFDHODH (2018) (0)
- CCDC 1045854: Experimental Crystal Structure Determination (2017) (0)
- An improbable journey: Creativity helped me make the transition from art to curing malaria (2018) (0)
- Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections (2019) (0)
- New targets for antimalarial drug discovery. (2022) (0)
- Antiplasmodial Peptaibols Act Through Membrane Directed Mechanisms (2022) (0)
- Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity (2022) (0)
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation (2023) (0)
- Human Polo-like Kinase Inhibitors as Antiplasmodials. (2023) (0)
- Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni (2018) (0)
- I pyrazolo pyridine derivatives as inhibitors of NADPH oxidase (2009) (0)
- Strategic collaboration between Medicines for Malaria Venture (MMV) and Antimicrobial and Biocontrol Agents Unit (AmBcAU) at the University of Yaoundé 1 identifies potent inhibitors of the causative agents of Amoebiasis, Buruli ulcer and Toxoplasmosis (2019) (0)
- A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL) (2022) (0)
- Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis (2023) (0)
- Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development. (2023) (0)
- Faculty Opinions recommendation of Finding functional features in Saccharomyces genomes by phylogenetic footprinting. (2003) (0)
- Screening the MMV Open Access Pathogen box unveils novel and potent inhibitors of Amoebiasis agent: Entamoeba histolytica (2019) (0)
- In vitro evolution and whole genome analysis to study chemotherapy drug resistance in haploid human cells (2022) (0)
- Chapter 4:Human Targets Repositioning and Cell-based Approaches for Antimalarial Discovery (2011) (0)
- Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity (2017) (0)
- 7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex (2023) (0)
- Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance (2017) (0)
- Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation (2016) (0)
- Plasmodium exoerythrocytic parasites redirect trafficking of human proteins to the parasitophorous vacuole (2023) (0)
- The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite (2021) (0)
- New Approaches to Finding Next‐Generation Treatments for Malaria (2015) (0)
- Synthesis of Annulated 2H‐Indazoles and 1,2,3‐ and 1,2,4‐Triazoles via a One‐Pot Palladium‐Catalyzed Alkylation/Direct Arylation Reaction. (2009) (0)
- Functional Genomics of Plasmodium falciparum: a new approach for identifying therapeutic targets against malaria (2005) (0)
- Plasmodium falciparum Niemann-Pick Type-C1 Related protein is a druggable target required for parasite membrane homeostasis (2019) (0)
- Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways (2022) (0)
- Discovering biomarkers of chemotherapy resistance using in vitro evolution in haploid human cells (2020) (0)
- Platypus ‐ A Streamlined Pipeline to Identify Plasmodium Genomic Variants, with Drug Development Applications (2012) (0)
- CCDC 1045851: Experimental Crystal Structure Determination (2017) (0)
- Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response (2020) (0)
- Further strategies for signature-tagged mutagenesis and the application of oligonucleotide microarrays for the quantification of DNA-tagged strains (2002) (0)
- CCDC 1045852: Experimental Crystal Structure Determination (2017) (0)
- Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum (2006) (0)
- Open Source Drug Discovery - Highly Potent Antimalarial Compounds Derived from the GlaxoSmithKline Tres Cantos Arylpyrroles (2013) (0)
- Proteins: Structural Properties and Expression Profiling Gene Family Encoding Maurer's Cleft Membrane Plasmodium A (2006) (0)
- Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box (2021) (0)
- Disease Transmission Prophylaxis, Treatment, and Prevention of Candidate with Potential for Use in KAF156 Is an Antimalarial Clinical (2014) (0)
- Target deconvolution using in vitro evolution in haploid human cells (2020) (0)
- Whole genome sequencing analysis of Plasmodium vivax using whole genome capture (2012) (0)
- Front Cover: Structure–Activity and Structure–Toxicity Relationships of Peptoid‐Based Histone Deacetylase Inhibitors with Dual‐Stage Antiplasmodial Activity (ChemMedChem 9/2019) (2019) (0)
- Flexing of DNA on the nucleosome core particle (1990) (0)
- The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle (1990) (0)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (0)
- Title Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 Permalink (2013) (0)
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