Emilio Hirsch
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Computer Science
Emilio Hirsch's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Emilio Hirsch's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology (2017) (2773)
- Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology (2017) (1891)
- Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation (2000) (1168)
- Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. (1997) (1038)
- PI3K/AKT signaling pathway and cancer: an updated review (2014) (869)
- Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. (1997) (675)
- Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. (2000) (673)
- Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response (2002) (644)
- Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. (2000) (617)
- Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways (2002) (608)
- Instruction manual for the ILAE 2017 operational classification of seizure types (2017) (606)
- Nitric oxide synthase and neuronal vulnerability in parkinson's disease (1996) (589)
- Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis (2005) (556)
- Neuroinflammatory processes in Parkinson's disease (2003) (522)
- Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis (1991) (517)
- PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects (2004) (478)
- PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization (2004) (402)
- Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease (2002) (383)
- Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology (2011) (380)
- GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction (2013) (365)
- Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate (2013) (360)
- Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins (1996) (356)
- Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. (2011) (342)
- Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. (2005) (334)
- Glial cells and inflammation in parkinson's disease: A role in neurodegeneration? (1998) (328)
- Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology (2009) (319)
- Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions. (1998) (314)
- Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload (2003) (303)
- Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (2016) (299)
- Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. (1999) (297)
- Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development (2008) (292)
- Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function (2002) (275)
- Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. (2004) (275)
- Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. (2002) (272)
- SRPX2 mutations in disorders of language cortex and cognition. (2006) (253)
- EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy (2001) (251)
- Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis (2000) (249)
- Skin wounds and severed nerves heal normally in mice lacking tenascin-C. (1996) (240)
- Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. (2012) (231)
- Landau‐Kleffner Syndrome: A Clinical and EEG Study of Five Cases (1990) (217)
- Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content? (1992) (216)
- Mutations of DEPDC5 cause autosomal dominant focal epilepsies (2013) (214)
- Nocturnal Hypermotor Seizures, Suggesting Frontal Lobe Epilepsy, Can Originate in the Insula (2006) (207)
- Landau‐Kleffner Syndrome: A Pharmacologic Study of Five Cases (1990) (203)
- Crosslinking of α-synuclein by advanced glycation endproducts — an early pathophysiological step in Lewy body formation? (2000) (201)
- Phosphoinositide 3-kinase signalling in the vascular system. (2008) (200)
- Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. (2016) (199)
- Resistance to thromboembolism in PI3Kγ‐deficient mice (2001) (198)
- Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK* (2000) (197)
- Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements (2000) (196)
- Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. (1999) (189)
- Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. (2011) (187)
- Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases (2013) (183)
- Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy (1995) (180)
- Integrin signalling: the tug-of-war in heart hypertrophy. (2006) (178)
- Neurocan Is Dispensable for Brain Development (2001) (175)
- NADPH oxidases in heart failure: poachers or gamekeepers? (2013) (172)
- PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function (2014) (169)
- Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase1 (2005) (167)
- An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease (1999) (167)
- Antiepileptic Effect of High-frequency Stimulation of the Subthalamic Nucleus (Corpus Luysi) in a Case of Medically Intractable Epilepsy Caused by Focal Dysplasia: A 30-month Follow-up: Technical Case Report (2002) (165)
- Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer. (2015) (164)
- Regional cerebral glucose metabolism in children with deterioration of one or more cognitive functions and continuous spike-and-wave discharges during sleep. (1995) (164)
- Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ (2005) (160)
- The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism (2003) (160)
- Epileptic encephalopathies of the Landau‐Kleffner and continuous spike and waves during slow‐wave sleep types: Genomic dissection makes the link with autism (2012) (160)
- Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. (1997) (159)
- Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice (2004) (159)
- A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress (2007) (158)
- Cognitive Development in Benign Focal Epilepsies of Childhood (1999) (158)
- Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence. (2004) (155)
- CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. (2008) (148)
- PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. (2007) (148)
- PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis (2007) (147)
- Methodology of photic stimulation revisited: Updated European algorithm for visual stimulation in the EEG laboratory (2012) (145)
- Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. (1999) (142)
- New signal transduction paradigms in anthracycline-induced cardiotoxicity. (2016) (141)
- Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. (2007) (139)
- Preservation of midbrain catecholaminergic neurons in very old human subjects. (2000) (138)
- Are dopaminergic neurons selectively vulnerable to Parkinson's disease? (1993) (136)
- Consensus on diagnosis and management of JME: From founder's observations to current trends (2013) (136)
- Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. (2010) (135)
- Genetic analyses of integrin function in mice. (1996) (135)
- Lipids on the move: phosphoinositide 3-kinases in leukocyte function. (2000) (135)
- Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. (2002) (134)
- Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. (2009) (133)
- Melusin Is a New Muscle-specific Interactor for β1Integrin Cytoplasmic Domain* (1999) (132)
- Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats (1992) (131)
- Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? (1990) (130)
- PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling (2015) (129)
- Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-&ggr; Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes (2008) (128)
- Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. (2002) (127)
- A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. (2012) (126)
- Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. (2007) (125)
- PI3K inhibition in inflammation: Toward tailored therapies for specific diseases (2010) (125)
- Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte. (1993) (124)
- Regulating neutrophil apoptosis: new players enter the game. (2011) (123)
- Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial‐onset seizures: A phase IIb, randomized, controlled trial (2013) (121)
- Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy (2001) (121)
- Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth (2018) (118)
- Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease. (1996) (114)
- A Selective Role for Phosphatidylinositol 3,4,5-Trisphosphate in the Gi-dependent Activation of Platelet Rap1B* (2003) (111)
- The landscape of epilepsy-related GATOR1 variants (2018) (110)
- Contralateral disappearance of parkinsonian signs after subthalamic hematoma (1992) (108)
- Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes? (2007) (106)
- Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP? (1993) (106)
- GRIN2A-related disorders: genotype and functional consequence predict phenotype (2018) (104)
- Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex. (2010) (104)
- Cerebral Glucose Utilization During Sleep in Landau‐Kleffner Syndrome: A PET Study (1990) (103)
- Involvement of Phosphoinositide 3-Kinase γ, Rac, and PAK Signaling in Chemokine-induced Macrophage Migration* (2004) (102)
- Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. (1997) (101)
- The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC (2018) (101)
- Crossroads of PI3K and Rac pathways (2015) (101)
- Evidence for digenic inheritance in a family with both febrile convulsions and temporal lobe epilepsy implicating chromosomes 18qter and 1q25‐q31 (2001) (101)
- Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model (2007) (99)
- Resistance to thromboembolism in PI3Kgamma-deficient mice. (2001) (98)
- Integrin function and regulation in development. (2000) (96)
- Mesencephalic cholinergic nuclei in progressive supranuclear palsy (1991) (95)
- Targeting myocardial remodelling to develop novel therapies for heart failure (2014) (94)
- Targeting PI3K in Cancer: Any Good News? (2013) (94)
- Plasma protein haptoglobin modulates renal iron loading. (2005) (93)
- In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. (2015) (93)
- Optimizing therapy of seizures in patients with renal or hepatic dysfunction (2006) (93)
- The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. (2007) (93)
- Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum (1996) (92)
- Genome-wide linkage scan of epilepsy-related photoparoxysmal electroencephalographic response: evidence for linkage on chromosomes 7q32 and 16p13. (2005) (92)
- The amygdala is critical for seizure propagation from brainstem to forebrain (1997) (91)
- Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families. (2000) (91)
- αv Integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development (1994) (91)
- PI3Kγ Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells (2009) (90)
- Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain (2002) (89)
- Dopaminergic cell group A8 in the monkey: Anatomical organization and projections to the striatum (1999) (89)
- p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. (2005) (88)
- Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1 (2003) (88)
- PRRT2 links infantile convulsions and paroxysmal dyskinesia with migraine (2012) (87)
- Inhibition of the substantia nigra suppresses absences and clonic seizures in audiogenic rats, but not tonic seizures: evidence for seizure specificity of the nigral control (2001) (86)
- Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. (1989) (85)
- Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration (2001) (84)
- Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3 (2019) (84)
- Classification of the epilepsies: New concepts for discussion and debate—Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology† (2016) (84)
- Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion1 (2006) (83)
- Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions (2007) (82)
- From rolandic epilepsy to continuous spike‐and‐waves during sleep and Landau‐Kleffner syndromes: Insights into possible genetic factors (2009) (81)
- An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology (2018) (81)
- Risk factors of postictal generalized EEG suppression in generalized convulsive seizures (2015) (81)
- Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation (2007) (80)
- Involvement of Phosphoinositide 3-Kinase &ggr; in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice (2010) (80)
- Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition1 (2007) (80)
- Normal Skeletal Development of Mice Lacking Matrilin 1: Redundant Function of Matrilins in Cartilage? (1999) (80)
- Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe (2016) (79)
- Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor* (2001) (79)
- Superoxide dismutase and Parkinson's disease (1990) (78)
- Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study. (1992) (77)
- ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (77)
- International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions (2022) (76)
- IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. (2011) (76)
- Tremor‐related activity of neurons in the ‘motor’ thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism (2003) (76)
- Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases (2005) (75)
- Future prospects of brain stimlation (2000) (75)
- Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep (2004) (74)
- PI3K and Calcium Signaling in Cardiovascular Disease (2017) (74)
- Phosphoinositide 3-Kinase &ggr; Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases (2012) (74)
- Nonredundant role of CCRL2 in lung dendritic cell trafficking. (2010) (74)
- Distribution of ataxin-7 in normal human brain and retina. (2000) (73)
- Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2 (2019) (73)
- Contractile Function During Angiotensin-II Activation (2015) (73)
- Familial cortical myoclonic tremor with epilepsy (2010) (72)
- Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease (1993) (72)
- Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes (1996) (71)
- A pro‐inflammatory signature mediates FGF2‐induced angiogenesis (2009) (71)
- C-fos expression after single and kindled audiogenic seizures in Wistar rats (1994) (71)
- Blockade of Phosphatidylinositol 3-Kinase (PI3K)δ or PI3Kγ Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis (2012) (70)
- Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio1 (2003) (70)
- Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model (2013) (70)
- Epilepsy, antiepileptic drugs (AEDs) and cognition (2003) (70)
- Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection (2007) (68)
- Anchoring Proteins as Regulators of Signaling Pathways (2012) (68)
- Integrin subunit expression associated with epithelial‐mesenchymal interactions during murine tooth development (1996) (68)
- The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role? (1990) (67)
- Cost‐effectiveness analysis of epilepsy surgery in a controlled cohort of adult patients with intractable partial epilepsy: A 5‐year follow‐up study (2016) (67)
- Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues. (2010) (67)
- The novel butyrate derivative phenylalanine‐butyramide protects from doxorubicin‐induced cardiotoxicity (2019) (67)
- FADD: A link between TNF family receptors and caspases in Parkinson’s disease (2002) (67)
- Class II PI3K Functions in Cell Biology and Disease. (2019) (67)
- Twice upon a time: PI3K's secret double life exposed. (2009) (66)
- A subset of genomic alterations detected in rolandic epilepsies contains candidate or known epilepsy genes including GRIN2A and PRRT2 (2014) (66)
- The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation (2010) (66)
- Electroclinical signs of benign neonatal familial convulsions (1993) (66)
- Immunocytochemical Quantification of Tyrosine Hydroxylase at a Cellular Level in the Mesencephalon of Control Subjects and Patients with Parkinson's and Alzheimer's Disease (1993) (65)
- Effects of Nigrostriatal Denervation and L‐Dopa Therapy on the GABAergic Neurons of the Striatum in MPTP‐treated Monkeys and Parkinson's Disease: An In Situ Hybridization Study of GAD67 mRNA (1995) (64)
- PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. (2011) (64)
- Correlation between PET and SISCOM in temporal lobe epilepsy. (2002) (64)
- Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis (2013) (63)
- Distribution of manganese-dependent superoxide dismutase in the human brain (1994) (63)
- Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery (2016) (62)
- Current standards of neuropsychological assessment in epilepsy surgery centers across Europe (2017) (62)
- PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control (2013) (62)
- Signaling through PI3Kγ: a common platform for leukocyte, platelet and cardiovascular stress sensing (2005) (62)
- Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis (2018) (62)
- Leukocyte transmigration is modulated by chemokine‐mediated PI3Kγ‐dependent phosphorylation of vimentin (2009) (62)
- A Single Cis-acting Element in a Short Promoter Segment of the Gene Encoding the Interphotoreceptor Retinoid-binding Protein Confers Tissue-specific Expression (*) (1995) (62)
- Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture. (2004) (62)
- Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines (2011) (62)
- S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase. (1999) (61)
- Present and future of PI3K pathway inhibition in cancer: perspectives and limitations. (2011) (61)
- Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. (2010) (61)
- Taming the PI3K team to hold inflammation and cancer at bay. (2008) (61)
- Myocyte signalling in leucocyte recruitment to the heart. (2014) (60)
- Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality? (2009) (60)
- PI3K in cancer–stroma interactions: bad in seed and ugly in soil (2014) (59)
- Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs (2020) (59)
- Liver X Receptor Activation Reduces Angiogenesis by Impairing Lipid Raft Localization and Signaling of Vascular Endothelial Growth Factor Receptor-2 (2012) (59)
- Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy (1995) (59)
- Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes (2018) (59)
- Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ (2007) (59)
- Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: A post mortem in situ hybridization study with special reference to Parkinson's disease (2005) (58)
- Idiopathic Rolandic Epilepsy with “Interictal” Facial Myoclonia and Oromotor Deficit: A Longitudinal EEG and PET Study (1999) (58)
- Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function. (2017) (58)
- Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase &ggr; Activity in Pressure Overload–Induced Cardiac Failure (2011) (57)
- Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. (2003) (57)
- Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU (2017) (57)
- Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility (2010) (57)
- Phosphoinositide 3‐kinase gamma; participates in T cell receptor‐induced T cell activation. (2008) (57)
- PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth (2013) (57)
- The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. (2008) (57)
- Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling. (2012) (56)
- Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury (2006) (56)
- γ-Hydroxybutyric acid induced spike and wave discharges in rats: Relation to high-affinity [3H]γ-hydroxybutyric acid binding sites in the thalamus and cortex (1993) (55)
- CHF6001 I: A Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-Inflammatory Activity and Suitable for Topical Pulmonary Administration (2015) (55)
- Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. (2003) (55)
- Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: Analysis of two randomized, double-blind, placebo-controlled studies (2009) (55)
- Distribution of 125I‐Ferrotransferrin Binding Sites in the Mesencephalon of Control Subjects and Patients with Parkinson's Disease (1993) (55)
- Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities (2018) (55)
- Mouse myoblasts can fuse and form a normal sarcomere in the absence of beta1 integrin expression. (1998) (55)
- Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. (2010) (54)
- PI3K kinase and scaffold functions in heart (2010) (53)
- GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys (1993) (53)
- Loss of PI3K&ggr; Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress (2010) (53)
- Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking. (2017) (52)
- Epidemiology of epilepsy. (2016) (52)
- Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. (2018) (51)
- Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer? (2020) (50)
- Epileptogenic networks in nodular heterotopia: A stereoelectroencephalography study (2017) (50)
- Targeting PI3K signaling in cancer: Challenges and advances. (2019) (49)
- Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP–intoxicated monkeys: Effect of levodopa and GM1 ganglioside therapy (1994) (49)
- Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease (2015) (49)
- Green fluorescent protein as a reporter of gene expression in transgenic mice. (1997) (49)
- Epilepsy and neuroprotection: an illustrated review. (2002) (48)
- Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. (2014) (48)
- Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. (2008) (48)
- PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. (2012) (47)
- Neuronal localization of copper-zinc superoxide dismutase protein and mRNA within the human hippocampus from control and Alzheimer's disease brains. (1991) (47)
- The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. (2011) (47)
- Nocturnal paroxysmal dystonia: a clinical form of focal epilepsy (1994) (46)
- Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. (2007) (46)
- ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (46)
- LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa‐induced motor alterations in Parkinsonian rats (2001) (46)
- Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain (1992) (46)
- PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress (2020) (45)
- Effects of L-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys. (1996) (45)
- Landau–Kleffner syndrome: sleep EEG characteristics at onset (2000) (45)
- Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. (2020) (45)
- Progressive supranuclear palsy (1991) (44)
- Seizures and the basal ganglia: a review of the clinical data. (2002) (43)
- Contribution of SISCOM Imaging in the Presurgical Evaluation of Temporal Lobe Epilepsy Related to Dysembryoplastic Neuroepithelial Tumors (2002) (43)
- Lack of phosphoinositide 3-kinase-&ggr; attenuates ventilator-induced lung injury* (2006) (43)
- Tyrosine kinase B messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study (1998) (43)
- Tumour biology. Weakening link to colorectal cancer (2001) (43)
- Ablation of Phosphoinositide 3-Kinase-γ Reduces the Severity of Acute Pancreatitis (2004) (42)
- Novel mutations in EPM2A and NHLRC1 widen the spectrum of Lafora disease (2010) (42)
- Targeting phosphoinositide 3-kinase γ to fight inflammation and more (2008) (42)
- Phosphoinositide 3-Kinases γ and δ, Linkers of Coordinate C5a Receptor-Fcγ Receptor Activation and Immune Complex-induced Inflammation* (2008) (42)
- Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study. (2000) (41)
- PI3K keeps the balance between metabolism and cancer. (2012) (41)
- Semiology of typical and atypical Rolandic epilepsy: a video-EEG analysis. (2002) (41)
- Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation. (2016) (41)
- Long‐term outcome after cognitive and behavioral regression in nonlesional epilepsy with continuous spike‐waves during slow‐wave sleep (2012) (41)
- Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease. (1997) (40)
- Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) (cid:1) 2 and PI3K (cid:1) pathways (2010) (40)
- Hypothalamic hamartoma: Epileptogenesis beyond the lesion? (2017) (40)
- Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice. (2011) (39)
- Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking (2019) (39)
- Eyelid fluttering, typical EEG pattern, and impaired intellectual function: A homogeneous epileptic condition among the patients presenting with eyelid myoclonia (2009) (39)
- Combined Measurements of Hippocampal N‐Acetyl‐Aspartate and T2 Relaxation Time in the Evaluation of Mesial Temporal Lobe Epilepsy: Correlation with Clinical Severity and Memory Performances (1999) (39)
- Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. (2014) (39)
- Epilepsies and video games: results of a multicentric study. (1998) (39)
- Integrating Cardiac PIP 3 and cAMP Signaling through a PKA Anchoring Function of p 110 g (39)
- Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes (1990) (38)
- Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: An exploratory, placebo-controlled study (2007) (38)
- A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation. (2012) (37)
- Heterogeneity and frequency of movement disorders in juvenile and adult-onset Niemann-Pick C disease (2013) (37)
- Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions. (2003) (37)
- Intracranial electrodes in the presurgical evaluation of epilepsy (2012) (36)
- Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer (2021) (36)
- PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway (2010) (36)
- Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys (1995) (36)
- Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells (2014) (36)
- Hypothalamic hamartoma: Is the epileptogenic zone always hypothalamic? Arguments for independent (third stage) secondary epileptogenesis (2013) (36)
- Phosphoinositide 3-kinase γ : kinase-dependent and -independent activities in cardiovascular function and disease (2004) (36)
- The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium. (2019) (36)
- Preventing and Treating Anthracycline Cardiotoxicity: New Insights. (2020) (36)
- Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH–dependent sympathetic drive (2014) (36)
- Hemopexin counteracts systolic dysfunction induced by heme‐driven oxidative stress (2017) (36)
- Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues (2017) (35)
- Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression (2018) (35)
- Landau–Kleffner syndrome is not an eponymic badge of ignorance (2006) (35)
- Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation (2013) (35)
- PI(3,4)P2 Signaling in Cancer and Metabolism (2020) (35)
- Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development. (1994) (35)
- PI3K‐C2α: One enzyme for two products coupling vesicle trafficking and signal transduction (2015) (35)
- Clinical and pathological features in hydrocarbon‐induced Parkinsonism (1996) (35)
- International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions (2022) (34)
- Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats (1992) (34)
- Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema (2010) (34)
- Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction (2018) (34)
- Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice. (1996) (34)
- Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl (2002) (33)
- PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts (2017) (33)
- Role of pontine nuclei damage in smooth pursuit impairment of progressive supranuclear palsy (1994) (33)
- Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure (2020) (33)
- Neural responses associated with positive and negative emotion processing in patients with left versus right temporal lobe epilepsy (2006) (33)
- Genetic analysis of β 1 integrin function : confirmed , new and revised roles for a crucial family of cell adhesion molecules (1997) (33)
- The influence of seizure frequency on anterograde and remote memory in mesial temporal lobe epilepsy (2014) (33)
- Antiepileptic Drug-Induced Pharmacodynamic Aggravation of Seizures (2003) (33)
- Neurologic presentations of renal diseases. (2010) (32)
- Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling (2015) (32)
- Subtraction ictal SPECT co-registered to MRI (SISCOM) in Sturge-Weber syndrome. (2005) (32)
- PI3K p110γ Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions (2013) (32)
- The proline‐rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside‐in signaling (2013) (32)
- Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. (2004) (31)
- PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development. (2015) (31)
- [Neuronal death caused by apoptosis in Parkinson disease]. (1997) (31)
- Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy. (2013) (31)
- Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities (2015) (31)
- Changes in GAD67 mRNA expression evidenced by in situ hybridization in the brain of R6/2 transgenic mice (2003) (30)
- Phosphoinositide 3‐kinase γ controls autonomic regulation of the mouse heart through Gi‐independent downregulation of cAMP level (2005) (30)
- Loss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy (2016) (29)
- Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response. (2019) (29)
- The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. (2010) (29)
- Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. (2020) (29)
- Phosphoinositide 3‐kinase p110γ in immunity (2011) (29)
- Neuromelanin accumulation with age in catecholaminergic neurons from Macaca fascicularis brainstem. (1993) (29)
- The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice (2000) (29)
- Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions (2022) (29)
- Essential role of phosphoinositide 3‐kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation (2009) (28)
- Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures. (2004) (28)
- Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. (2003) (28)
- Expression of 1 integrin complexes on the surface of unfertilized mouse oocyte (28)
- Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease (2021) (28)
- Co‐Occurrence of infantile epileptic seizures and childhood paroxysmal choreoathetosis in one family: Clinical, EEG, and SPECT characterization of episodic events (2002) (27)
- Therapeutic applications of PI3K inhibitors in cardiovascular diseases. (2013) (27)
- Short-interval amygdala kindling in neonatal rats. (1993) (27)
- Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits (2016) (27)
- Functions of PDE3 Isoforms in Cardiac Muscle (2018) (27)
- SPM analysis of ictal–interictal SPECT in mesial temporal lobe epilepsy: Relationships between ictal semiology and perfusion changes (2009) (26)
- The ideal characteristics of antiepileptic therapy: an overview of old and new AEDs (2003) (26)
- Lupus Anticoagulant Induced by the Combination of Valproate and Lamotrigine (1999) (26)
- Signaling pathways underlying anthracycline cardiotoxicity. (2020) (26)
- Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology. (2013) (26)
- trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study. (1998) (26)
- PI3K signaling in the pathogenesis of obesity: The cause and the cure. (2015) (26)
- Update on the genetics of the epilepsy-aphasia spectrum and role of GRIN2A mutations. (2019) (26)
- KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP. (2019) (26)
- PI3Ks and small GTPases in neutrophil migration: two sides of the same coin. (2013) (26)
- Phosphoinositide 3‐kinaseγ (PI3Kγ) controls L‐type calcium current (ICa,L) through its positive modulation of type‐3 phosphodiesterase (PDE3) (2006) (25)
- Hypoxemia following generalized convulsive seizures (2019) (25)
- Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response (2014) (25)
- Pharmacologic Inhibition of Phosphoinositide 3-Kinase Gamma (PI3Kγ) Promotes Infarct Resorption and Prevents Adverse Cardiac Remodeling After Myocardial Infarction in Mice (2010) (24)
- Glutamic acid decarboxylase mRNA expression in medial and lateral pallidal neurons in the MPTP-treated monkey and patients with Parkinson's disease. (1996) (24)
- Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics (2018) (24)
- Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception (2012) (24)
- Morgana acts as an oncosuppressor in chronic myeloid leukemia. (2015) (24)
- Phosphoinositide 3-kinases in health and disease. (2012) (24)
- Tyrosine hydroxylase gene expression in human ventral mesencephalon: Detection of tyrosine hydroxylase messenger RNA in neurites (1990) (23)
- Efficacy and safety in frameless robot-assisted stereo-electroencephalography (SEEG) for drug-resistant epilepsy. (2017) (23)
- Galanin pathogenic mutations in temporal lobe epilepsy. (2015) (23)
- Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (23)
- Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum (1993) (23)
- Dichotic listening performances in the follow-up of Landau and Kleffner syndrome (1997) (23)
- Contribution of T2Relaxation Time Mapping in the Evaluation of Cryptogenic Temporal Lobe Epilepsy (1998) (23)
- Mutations in the Novel Protein PRRT2 Cause Infantile Convulsions with Paroxysmal Kinesigenic Dyskinesia (2012) (23)
- [Cognitive consequences of Rolandic Epilepsy]. (2001) (23)
- Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 (2018) (22)
- [Cost-effectiveness of epilepsy surgery in a cohort of patients with medically intractable partial epilepsy--preliminary results]. (2004) (22)
- p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity (2019) (22)
- Basal ganglia involvement in rotational seizures. (1999) (22)
- Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential. (2008) (22)
- CC-Chemokine Ligand 16 Induces a Novel Maturation Program in Human Immature Monocyte-Derived Dendritic Cells1 (2006) (22)
- Postencephalitic stereotyped involuntary movements responsive to L‐Dopa (1996) (21)
- Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl. (2015) (21)
- New Insights into the Clinical Management of Partial Epilepsies (2000) (21)
- KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum. (2021) (21)
- Key role of PI3Kγ in monocyte chemotactic protein‐1‐mediated amplification of PDGF‐induced aortic smooth muscle cell migration (2012) (21)
- More than just kinases: the scaffolding function of PI3K. (2010) (21)
- Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling. (2015) (20)
- Visual and auditory socio-cognitive perception in unilateral temporal lobe epilepsy in children and adolescents: a prospective controlled study. (2014) (20)
- Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus (1993) (20)
- Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia (2016) (20)
- Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2–2q11.2 (2016) (20)
- The RhoA‐associated protein Citron‐N controls dendritic spine maintenance by interacting with spine‐associated Golgi compartments (2008) (20)
- PI3Kγ integrates cAMP and Akt signalling of the μ‐opioid receptor (2014) (20)
- Mild malformations of cortical development in sleep‐related hypermotor epilepsy due to KCNT1 mutations (2018) (20)
- Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ−/− mice causes alveolar macrophage deficiency and fatal respiratory viral infection (2017) (19)
- Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting (2018) (19)
- Modulation of μ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ (2010) (19)
- PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation (2021) (19)
- Specific PI3K Isoform Modulation in Heart Failure: Lessons from Transgenic Mice (2011) (18)
- Epilepsy and Videogames (2004) (18)
- Benign childhood epilepsy with centrotemporal spikes: Is it always benign? (2000) (18)
- Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. (2004) (18)
- Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. (2015) (18)
- Phosphoinositide 3-kinasegamma (PI3Kgamma) controls L-type calcium current (ICa,L) through its positive modulation of type-3 phosphodiesterase (PDE3). (2006) (18)
- Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure. (2014) (18)
- Analysis of the murine phosphoinositide 3-kinase γ gene (2000) (17)
- Summary PTX 3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization (2004) (17)
- Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases* (2012) (17)
- Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis (2018) (17)
- Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia (2020) (17)
- Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months (2016) (16)
- Angiogenesis in metabolic-vascular disease (2017) (16)
- Increase of valproate‐induced hyperammonemia in normal subjects by carbohydrate intake (1984) (16)
- [Parkinson disease: mechanisms of cell death]. (2002) (16)
- Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions (2010) (16)
- New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole. (2019) (16)
- Pure endoscopic management of epileptogenic hypothalamic hamartomas (2017) (16)
- Levetiracetam: preliminary efficacy in generalized seizures. (2003) (16)
- gamma-Hydroxybutyric acid induced spike and wave discharges in rats: relation to high-affinity [3H]gamma-hydroxybutyric acid binding sites in the thalamus and cortex. (1993) (16)
- Selective memory impairment for public events in a patient with left temporal lobe epilepsy (2005) (15)
- The beta 1 integrin distal promoter is developmentally regulated in transgenic mice. (1993) (15)
- Landau–Kleffner syndrome: a rare childhood epileptic aphasia (1999) (15)
- Metabolomic characterization of human hippocampus from drug‐resistant epilepsy with mesial temporal seizure (2018) (15)
- Dramatic changes in artistic preference after left temporal lobectomy (2003) (14)
- Operationale Klassifikation der Anfallsformen durch die Internationale Liga gegen Epilepsie: Positionspapier der ILAE-Klassifikations- und Terminologiekommission (2018) (14)
- Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease (2015) (14)
- Rac signal adaptation controls neutrophil mobilization from the bone marrow (2016) (14)
- Late onset heart failure after childhood chemotherapy. (2019) (14)
- Long-term outcome in neuroZika (2019) (14)
- Language‐induced Epilepsy, Acquired Stuttering, and Idiopathic Generalized Epilepsy: Phenotypic Study of One Family (2006) (14)
- Methods to measure the enzymatic activity of PI3Ks. (2014) (14)
- Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors. (2011) (14)
- Ciliary Neurotrophic Factor Constitutively Expressed in the Nervous System of Transgenic Mice Protects Embryonic Dorsal Root Ganglion Neurons from Apoptosis (1996) (14)
- How PI3K-derived lipids control cell division (2015) (14)
- ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models (2014) (14)
- The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. (2015) (13)
- PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis (2012) (13)
- Contractile Function During Angiotensin-II Activation Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban (13)
- Adjunctive antiepileptic drugs in adult epilepsy: how the first add-on could be the last (2010) (13)
- Dorsal tegmentum kindling in rats (1992) (13)
- Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs (2017) (13)
- Focal epilepsy in SCN1A‐mutation carrying patients: is there a role for epilepsy surgery? (2020) (12)
- The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model (2019) (12)
- Gangliosides and parkinsonism (1993) (12)
- Mechanisms underlying the cross‐talk between heart and cancer (2020) (12)
- Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut (2017) (12)
- Phosphoinositides in cell proliferation and metabolism. (2020) (12)
- A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials (2021) (12)
- Antiglial Cell Autoantibodies and Childhood Epilepsy: A Case Report (2005) (12)
- Pathophysiological aspects of Landau-Kleffner syndrome: from the active epileptic phase to recovery. (2001) (11)
- High affinity neurotrophin receptors in cholinergic neurons in the human brain. (1994) (11)
- Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. (2014) (11)
- The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc 42 Activation (2008) (11)
- CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients. (2021) (11)
- Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia (2022) (11)
- [Children with drug-resistant partial epilepsy: criteria for the identification of surgical candidates]. (2004) (11)
- Exome sequencing in 57 patients with self-limited focal epilepsies of childhood with typical or atypical presentations suggests novel candidate genes. (2020) (10)
- Analysis of the murine phosphoinositide 3-kinase gamma gene. (2000) (10)
- Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth (2019) (10)
- Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (2016) (10)
- PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice. (2017) (10)
- High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia (2019) (10)
- PI3K Signaling in Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and Acute Lung Injury (2022) (10)
- [Autosomal dominant nocturnal frontal lobe epilepsy]. (1998) (9)
- Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures (2018) (9)
- Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply (2016) (9)
- 2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction (2019) (9)
- Peri-Implantation Lethality in Mice Lacking the Sm Motif-Containing Protein Lsm4 (2000) (9)
- Targeting the Extracellular HSP90 Co-Chaperone Morgana Inhibits Cancer Cell Migration and Promotes Anticancer Immunity (2021) (9)
- Inhalation of the prodrug PI 3 K inhibitor CL 27 c improves lung function in asthma and fi brosis (2018) (9)
- Generalized seizures : from clinical phenomenology to underlying systems and networks /Edouard Hirsch ...[et al.] (2006) (9)
- Data demonstrating the anti-oxidant role of hemopexin in the heart (2017) (9)
- Regional and cellular presenilin 2 (STM2) gene expression in the human brain. (1996) (9)
- Contribution of T2 relaxation time mapping in the evaluation of cryptogenic temporal lobe epilepsy. (1998) (9)
- The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. (2014) (9)
- Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia (2017) (9)
- Loss of β1-integrin-deficient cells during the development of endoderm-derived epithelia (2003) (8)
- Non-linear analysis of epileptic seizures I. Correlation-dimension measurements for absence epilepsy and near-periodic signals (1999) (8)
- PI3Ks in Diabetic Cardiomyopathy (2017) (8)
- Hypermetabolism during resting-state FDG-PET suggesting intrinsic epileptogenicity in focal cortical dysplasia. (2014) (8)
- [Autoimmune encephalitis, clinical, radiological and immunological data]. (2013) (8)
- Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-α and Tfr2-β isoforms in different tissues (8)
- Therapeutic peptides for the treatment of cystic fibrosis: Challenges and perspectives. (2021) (7)
- Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage (2019) (7)
- Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy. (2017) (7)
- Can histologically normal epileptogenic zone share common electrophysiological phenotypes with focal cortical dysplasia? SEEG-based study in MRI-negative epileptic patients (2019) (7)
- Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus (1992) (7)
- Impairment in auditory verbal processing and dichotic listening after recovery of epilepsy in Landau and Kleffner Syndrome (1999) (7)
- Inactivation of PI3K (cid:1) and PI3K (cid:2) distorts T-cell development and causes multiple organ inflammation (2007) (7)
- Erratum to: Regulating neutrophil apoptosis: new players enter the game [Trends in Immunology (2011) 32, 117–124] (2011) (7)
- Overlapping and distinct roles for PI 3 K b and g isoforms in S 1 P-induced migration of human and mouse endothelial cells (2008) (7)
- Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure. (2010) (6)
- Early dissociation of verbal and nonverbal gestural ability in an epileptic deaf child (1999) (6)
- Measuring PI3K lipid kinase activity. (2012) (6)
- Epileptic encephalopathy with continuous spike‐waves during sleep: The need for transition from childhood to adulthood medical care appears to be related to etiology (2014) (6)
- Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims (2008) (6)
- Protective Role of the M-Sec–Tunneling Nanotube System in Podocytes (2021) (6)
- Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels. (2006) (6)
- Tumour biology (Communication arising): Weakening link to colorectal cancer? (2001) (6)
- Magnetically enriched bone marrow‐derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice (2008) (6)
- Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases (2021) (6)
- Isotope tracer-techniques in rolandic epilepsy and its variants. (2001) (6)
- Correction: The landscape of epilepsy-related GATOR1 variants (2018) (6)
- Cancer: Natural-born killers unleashed (2014) (6)
- [Benign familial neonatal convulsions: a model of idiopathic epilepsy]. (1999) (6)
- Structural basis of phosphatidylinositol 3-kinase C2α function (2022) (6)
- Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial (2016) (6)
- PI 3 KC 2 a : One enzyme for two products coupling vesicle trafficking and signal transduction (2015) (6)
- [Postures and abnormal paroxysmal movements during sleep: hypnogenic paroxysmal dystonia or partial epilepsy?]. (1991) (6)
- [Selective memory impairment for public events associated with accelerated forgetting in a patient with left temporal lobe epilepsy]. (2006) (6)
- Role of Protein Kinase A-Mediated Phosphorylation in CFTR Channel Activity Regulation (2021) (5)
- Short Interval Electrical Amygdala Kindling in Infant Rats (1998) (5)
- Phosphoinositides and cardiovascular diseases. (2012) (5)
- Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity (2021) (5)
- Comment from Dorothée G.A. Kasteleijn-Nolst Trenité, Edouard Hirsch, Ronald C. Reed, Bassel Abou-Khalil, and Bernd Schmidt on: How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? (2014) (5)
- Post-Wortmannin Era: Novel Phosphoinositide 3-Kinase Inhibitors with Potential Therapeutic Applications (2009) (5)
- DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls. (2019) (5)
- Calming down T cell acute leukemia. (2012) (5)
- Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (5)
- Preserved anterograde and remote memory in drug-responsive temporal lobe epileptic patients (2015) (5)
- Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study (2019) (5)
- [Medicoeconomic assessment of epilepsy surgery in adults with medically intractable partial epilepsy. Three-year outcomes from a multicenter French cohort]. (2008) (5)
- Corrigendum: A selective inhibitor reveals PI3Kγ dependence of T H 17 cell differentiation (2012) (5)
- High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice (2011) (5)
- Ultrastructural relations between nigrostriatal dopaminergic neurons and cholinergic nerve endings in the human brain. (1993) (5)
- Encephalopathy related to Status Epilepticus during slow Sleep: from concepts to terminology. (2019) (5)
- [Parkinson's disease: cell death mechanisms] (2002) (5)
- Analysis of regulatory regions of the ciliary neurotrophic factor gene in transgenic mice (1995) (5)
- Aging, disease and death of nerve cells. (1996) (5)
- Comparison of Functional Deficit Zone Defined by FDG PET to the Epileptogenic Zones Described in Stereo-Electroencephalograph in Drug-Resistant Epileptic Patients Treated by Surgery. (2019) (5)
- A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage (2020) (4)
- Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis. (2014) (4)
- Isolated paroxysmal arousals as focal epilepsy. (2006) (4)
- Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF) (2017) (4)
- Misleading features of neuroimaging and electroencephalography: insulinoma misdiagnosed as temporal lobe epilepsy (2013) (4)
- Section of the corpus callosum in kainic acid induced seizures in rats: behavioral, electroencephalographic and neuropathological study (1992) (4)
- Decrease of valproate-induced hyperammonemia in normal subjects by lipid ingestion (1985) (4)
- [Basal ganglia deep-brain stimulation for treatment of drug-resistant epilepsy: review and current data]. (2008) (4)
- IMPACT OF P-GLYCOPROTEIN ON THE DISTRIBUTION OF [F-18] MPPF IN PHARMACORESISTANT TEMPORAL LOBE EPILEPSY (2010) (4)
- Nocturnal paroxysmal dystonia. (1993) (4)
- Corrigendum to: Integrin signalling: The tug-of-war in heart hypertrophy [Cardiovascular Research 70 (2006) 422–433] (2006) (4)
- Towards a definition of the "practical" epileptogenic zone: a case of epilepsy with dual pathology. (2006) (4)
- Genetic Evidence for a Predominant Role of PI3Kβ In ITAM— and Integrin-Mediated Signaling in Platelets (2008) (4)
- ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation (2020) (4)
- Tissue-specific KO of ECM proteins. (2009) (4)
- Adrenal transplant, dopaminergic neurons, and Parkinson' disease (1993) (4)
- [Should new generation antiepileptic drugs be prescribed as first-line treatment of newly diagnosed epilepsy in adolescents and adults?]. (2003) (4)
- Requirement for PI 3-kinase g in macrophage migration (2003) (3)
- Childhood epilepsy syndromes with both focal and generalized seizures (2005) (3)
- [Diurnal and nocturnal paroxysmal dyskinesia in young children: a new entity?]. (1997) (3)
- Key role of PI 3 K g in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration (2012) (3)
- The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors (2015) (3)
- PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ1-Stimulated Cardiomyocytes (2021) (3)
- Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer (2022) (3)
- Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer (2022) (3)
- Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis. (2015) (3)
- Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy (2021) (3)
- Characterization of the beta1 integrin gene promoter (1992) (3)
- Use of suggestive seizure manipulation methods in the investigation of patients with possible psychogenic nonepileptic seizures—An international ILAE survey (2021) (3)
- Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype? (2017) (3)
- Classification as autonomic versus sensory seizures (2019) (3)
- [Epilepsy surgery in children: from a multidisciplinary network to the creation of an expertise and care centre]. (2008) (2)
- Chatting Second Messengers: PIP3 and cAMP (2017) (2)
- Three Different FDG Patterns in Periventricular Nodular Heterotopia Correlated to Video Stereoelectroencephalography. (2021) (2)
- Other Probable Syndromes of Idiopathic Generalized Epilepsies (2010) (2)
- Statistical Kernel-based Modeling of Connectomes (2012) (2)
- p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (2)
- [Refractory partial epilepsy: what are the neuropediatrician's criteria for drug resistance?]. (2004) (2)
- Edinburgh Research Explorer Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions (2018) (2)
- 'Circulating' RNA-based therapies in Cardio-Oncology. (2022) (2)
- Predictive factors of epilepsy in arteriovenous malformation (2020) (2)
- Potential therapeutic applications of AKAP disrupting peptides. (2020) (2)
- Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy (2022) (2)
- [An atypical form of neurosarcoidosis]. (2013) (2)
- Electroconvulsive therapy for psychosis in a patient with epilepsy related to hypothalamic hamartoma (2013) (2)
- Phosphoinositide-3 kinase gamma kinase activity significantly contributes to the pathophysiology of sepsis and multiorgan failure (2008) (2)
- Two signalling hands for uPAR (2013) (2)
- SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution (2020) (2)
- Monocyte-Derived Dendritic Cells Maturation Program in Human Immature CC-Chemokine Ligand 16 Induces a Novel (2006) (2)
- [Memory improvement in patients with temporal lobe epilepsy at one-year postoperative]. (2011) (2)
- PI3K signaling: a crossroads of metabolic regulation (2009) (2)
- Inflaming attraction by RNA (2012) (1)
- TRANSITORY COGNITIVE DISORDERS AND LEARNING IMPAIRMENT (2001) (1)
- COMMENTARY Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules (1997) (1)
- Inhibitory role of the acute phase proteins on neutrophil migration in severe sepsis (2009) (1)
- Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance (2021) (1)
- Commentary on the usefulness of a morning routine EEG recording in patients with juvenile myoclonic epilepsy (2008) (1)
- Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. (2021) (1)
- P1938In vitro characterization of a novel PI 3-kinase inhibitor for growth factor-induced effects in pulmonary artery smooth muscle cells (2019) (1)
- Oxidative stress in anticancer therapies-related cardiac dysfunction. (2021) (1)
- Signal transduction in inflammation (2005) (1)
- Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation (2022) (1)
- Noncatalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage. (2020) (1)
- Abstract 21531: Inducible Kinase-Independent Effects of Phosphoinositide-3-Kinase Gamma on Cardiac Contractility (2010) (1)
- PHOSPHOINOSITIDE-3 KINASE GAMMA ACTIVITY CONTRIBUTES TO BACTERIAL DISSEMINATION DURING ABDOMINAL SEPSIS (2009) (1)
- Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and in patients with Alzheimer's disease (1989) (1)
- Epilepsy and neuroprotection (2002) (1)
- Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU (2017) (1)
- [Fits, faints and blackouts in the adult]. (2003) (1)
- [Is there a bridge between migraine and familial mesial temporal lobe epilepsy?]. (2009) (1)
- EEG in fitness to drive evaluations in people with epilepsy — Considerable variations across Europe (2020) (1)
- Epileptic syndromes with focal seizures of childhood and adolescence. (2012) (1)
- Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular traf fi cking Advances in Biological Regulation (1)
- The turtle and the rabbit story in a modern (PI3)key (2018) (1)
- PI3Kγ inhibition protects from anthracycline-induced heart failure and reduces tumor growth (2018) (1)
- Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (1)
- A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases (2022) (1)
- Announcement: Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure (2013) (1)
- Tumor biology: mouse models of colon cancer (2001) (1)
- Vagus nerve stimulation in epilepsy: Efficiency and safety of outpatient practice. (2020) (1)
- Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance (2020) (1)
- Correction to: The landscape of epilepsy-related GATOR1 variants (2018) (1)
- A clinical study of 21 European families with dominant partial epilepsy (1999) (1)
- Smooth pursuit in progressive supranuclear palsy (1995) (1)
- [Epilepsy in the child and in the adult: Second part--adult epilepsy]. (2004) (0)
- Nontoxic Stress Condition MAPK Regulates IL-4 Production in BMMC Selective Activation of Fyn / PI 3 K and p 38 (2007) (0)
- Inactivation of catalytic and non-catalytic PI3 kinase gamma functions enhances hypoxia-induced pulmonary hypertension in mice (2022) (0)
- University of Southern Denmark Mild malformations of cortical development in sleep-related hypermotor epilepsy due to KCNT1 mutations Rubboli, (2019) (0)
- PHOSPHOINOSITIDE 3 KINASE BETA ATTENUATES INFLAMMATION AND FIBROSIS IN A BLEOMYCIN MODEL OF ACUTE LUNG INJURY (2009) (0)
- Crystal Structure of human PI3Kgamma complexed with AS605240 (2005) (0)
- Integrative Physiology Involvement of Phosphoinositide 3-Kinase in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice (2010) (0)
- Generalized Convulsive Seizure Type, Oxygen Administration, Postictal Generalized EEG Suppression, and SUDEP Risk: Are They Related? (2016) (0)
- IDENTIFICATION OF A FIRST AND MAJOR GENE FOR ACQUIRED EPILEPTIC APHASIA (LANDAU-KLEFFNER SYNDROME) AND RELATED CHILDHOOD FOCAL EPILEPSIES AND ENCEPHALOPATHIES WITH SPEECH AND LANGUAGE DYSFUNCTION (2013) (0)
- Abnormal postures and movements during sleep (2003) (0)
- of the Rho-GTPase via disruption of ArhGAP15 results in reduced architectural and functional complexity (0)
- [Gougerot-Sjögren syndrome and polymyositis]. (1983) (0)
- Inhibitors of Phosphatidylinositol 3-Kinases, compositions and uses thereof (2010) (0)
- P318Phosphoinositide 3-kinase gamma inhibition as a novel strategy to reactivate targeted autophagy and limit Doxorubicin-induced cardiotoxicity (2018) (0)
- [In this era of value for money what is the place of epilepsy surgery in hospital practice]. (2007) (0)
- Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation (2023) (0)
- PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium (2012) (0)
- functions The RacGAP ArhGAP15 is a master negative regulator of neutrophil (2012) (0)
- Current treatment options for Familial Adult Myoclonus Epilepsy. (2023) (0)
- INCREASED SUSCEPTIBILITY TO INTESTINAL INFLAMMATION OF MICE DEFICIENT IN TIR8, AN INHIBITORY MEMBER OF IL-1 RECEPTOR FAMILY EXPRESSED IN EPITHELIAL AND DENDRITIC CELLS (2004) (0)
- P032 Chemical optimisation of a PI3Kγ competing peptide for the therapy of cystic fibrosis (2021) (0)
- Guido Tarone (1951-2015). (2015) (0)
- Treatment of Epilepsy : Focus on Levetiracetam (2005) (0)
- Correction: The landscape of epilepsy-related GATOR1 variants (2018) (0)
- The tyrosine kinase Pyk2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha IIb beta 3 (2011) (0)
- Tissue-specific KO of ECM proteins. (2000) (0)
- Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689)) (2015) (0)
- Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2–2q11.2 (2016) (0)
- Cell Invasion-PI 3 K-Induced Systemic Lupus but Not T A ( PI 3 K ) Deficiency Ameliorates I-Phosphatidylinositol 3-KinaseBClass (2005) (0)
- Post-encephalitic extra-pyramidal syndrome associating akinesia and stereotyped movements responsive to L-dopa (1996) (0)
- [Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures]. (2007) (0)
- The unexpected role of PI3-kinase gamma in pulmonary hypertension (2020) (0)
- PI3KC2α: A novel key player in cardiac contractility and DOX-induced cardiotoxicity? (2022) (0)
- Determination of positive and negative regulatory elements. (1999) (0)
- Quantitation of Protein Phosphorylation Using Stable Isotope Dimethyl Labeling Coupled with Immobilized Metal Affinity Chromatography ( IMAC ) and Mass Spectrometry (2005) (0)
- PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress (2020) (0)
- Analysis of Protein Phosphorylation in Halobacterium salinarum Analysis of Ser/Thr Phosphorylation by MALDI Mass Spectrometry A Novel Combined Genetic and Proteomic Approach to Identify PI3Kgamma-dependent Phosphorylated Proteins (2005) (0)
- Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis (2018) (0)
- Doxorubicin-induced mitochondrial damage activates PI3Kgamma and inhibits protective cardiac autophagy (2018) (0)
- PI3Kγ/AKT1 signaling in macrophages is essential for resistance against Trypanosoma cruzi infection (2015) (0)
- Characterization of early cardiotoxicity action of calcineurin inhibitors (2018) (0)
- Erratum: PTX3 plays a key role in the organization of the cumulus oophrus extracellular matrix and in in vivo fertilization (Development vol. 131 (1577-1586)) (2004) (0)
- Putative role of tumor necrosis factor in the loss of dopaminergic neurons in Parkinson's disease (1992) (0)
- Hyper-activation of the Rho-GTPase Rac1 via disruption of ArhGAP15 results in reduced architectural and functional complexity (2015) (0)
- Effects of AAV9-mediated cardiac phosphodiesterase 4B and 2A overexpression in a mouse model of heart failure with preserved ejection fraction (2022) (0)
- PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation (2015) (0)
- Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells (2022) (0)
- Crystal Structure of human PI3Kgamma complexed with AS604850 (2005) (0)
- Polymer blends for vascular tissue engineering (2012) (0)
- Melusin: A cardioprotective chaperone able to modulate lipid metabolism and ROS production in the heart (2020) (0)
- Abstract 4988: PI3Kγ-deficiency protects against pancreatic tumorigenesis at the expense of diet-Induced hyperlipidemia and hepatotoxicity (2018) (0)
- Rucaparib blocks SARS-CoV-2 virus binding to cells and interleukin-6 release in a model of COVID-19 (2022) (0)
- Salvage pathways in heart rejuvenation. (2016) (0)
- Phosphoinositide 3-kinase gamma at the crossroad between autophagy and metabolic control in doxorubicin-induced cardiomyopathy (2022) (0)
- and p 85 / p 110 heterodimer immune synapse independently of its capacity to interact with the CD 28 provides T cell costimulation and enhances PI 3 K activity at the (2007) (0)
- P4477Pi3kgamma inhibition rescues mice from acute cardiac contractile dysfunction, acquired long QT syndrome (acLQTS) and sudden death caused by calcineurin inhibitors (2017) (0)
- Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
- Role of pentraxin 3 in female fertility (2005) (0)
- Response to the Letter by Seropian et al (2010) (0)
- Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 (2018) (0)
- Species Generation-Dependent Neutrophil Reactive Oxygen Regulation of Adhesion-Independent and Kinases Play a Nonredundant Role in Class I Phosphoinositide-3-Kinases and Src (2013) (0)
- Introduction of mutations into the murine integrin gene by homologous recombination (1990) (0)
- 5 PIK3c2G loss promotes pancreatic cancer through MTOR regulation and metabolic rewiring (2018) (0)
- Role of PI3Kλ in β-adrenergic stimulation of cardiac contractility and L-type calcium current (2002) (0)
- Melusin protects from cardiac rupture and improves functional remodelling in mice after myocardial infarction (2013) (0)
- Revue de la littératureAntiepileptic drugs, H Levy, R Mattson, BS Meldrum, Fourth Edition, Raven Press, New York (1995), p. 1120 (1996) (0)
- 0377 : Phosphoinositide 3-kinase gamma: a potential clinical target in the prevention of vascular damages inuced by arterial injury (2015) (0)
- Abstract IA22: Innate immune cell PI3K gamma as a target for suppression of pancreatic ductal adenocarcinoma (2015) (0)
- Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage (2019) (0)
- Chapter 2 Phosphoinositides and Cardiovascular Diseases (2012) (0)
- Cardiac gene therapy of heart failure with phosphodiesterase PDE4B in mice (2019) (0)
- Brief report Genetic evidence for a predominant role of PI3K (cid:1) catalytic activity in ITAM- and integrin-mediated signaling in platelets (2009) (0)
- Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer (2020) (0)
- PI3KC2α, a new spindle associated protein involved in genomic instability and tumorigenesis (2016) (0)
- Prokineticin-izing Doxorubicin-Damaged Hearts (2019) (0)
- Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia (2015) (0)
- Response to the numbering of seizure types (2017) (0)
- Role and regulation of phosphatidylinositol 3-kinase (cid:1) in platelet integrin (cid:2) 2 (cid:1) 1 signaling (2012) (0)
- Announcement: Heterocellular signalling and crosstalk in the heart in ischaemia and heart failureto be published in May, 2014 (2013) (0)
- Stroke-like migraine attacks after radiation therapy : une complication tardive de la radiothérapie cérébrale (2014) (0)
- Idiopathic epilepsy and cortical tremor of adult onset (2004) (0)
- Chemical Oral Cancerogenesis Is Impaired in PI3Kγ Knockout and Kinase-Dead Mice (2021) (0)
- Antiepileptic drugs, Fourth Edition, H Levy, R Mattson, BS Meldrum. Raven Press, New York (1995), 1120 (1996) (0)
- Response by Vandecasteele et al to Letter Regarding Article, "Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure". (2021) (0)
- Loss of PI3K-Gamma Scaffold Function causes Severe Electrical Remodeling in Mice Ventricular Myocytes (2015) (0)
- A microfluidic device for cell migration measures in response to chemical stimuli (2008) (0)
- Cdo Deficient Mice Display Cardiomyopathy with Alterations in Connexins (2015) (0)
- Choking Fits During Sleep Related to Epilepsy. (2016) (0)
- Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia (2017) (0)
- Cardiac gene therapy with PDE2A limits ventricular remodeling, dysfunction and arrhythmias promoted in mice by chronic infusion with catecholamines (2022) (0)
- haptoglobin/hemopexin double-null mice after acute hemolysis Enhanced splenomegaly and severe liver inflammation in (2013) (0)
- Subthalamic nucleus and substantia nigra pars reticulata stimulation: the Grenoble experience (2020) (0)
- O157 Mapping the function and connectivity of the cingulate gyrus using stereo-encephalography (SEEG) (2017) (0)
- -morgana haploinsufficiency causes in mice a lethal and transplantable CML like myeloid neoplasm -morgana is underexpressed in aCML and in a subgroup of CMLs where predicts a worse response (0)
- PO-466 PI3K-C2A regulates mitotic spindle assembly and chemotherapy response in breast cancer (2018) (0)
- Non catalytic function of PI3Kg on smooth muscle cells proliferation: a novel therapeutic strategy to prevent arterial remodeling through cAMP modulation (2017) (0)
- Integrins in development 725 Integrin function and regulation in development (2000) (0)
- Editorial to the SI Leukocyte Adhesion and Migration. (2013) (0)
- Vascular Remodeling in Cardiovascular Disease (2016) (0)
- Chronic treatment with catecholamines favoured spontaneous calcium waves upon β-AR stimulation at the cellular level and promoted susceptibility to ventricular arrhythmias in vivo evoked by catheter-mediated (0)
- Role of phosphoinositide 3-kinasese gamma in an ex-vivo model of ventilator induced lung injury. (2004) (0)
- Comparison of 3 Tfr2- deficient murine models suggests distinct functions for Tfr2- (cid:1) and Tfr2- (cid:2) isoforms in different tissues (2010) (0)
- Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells (2014) (0)
- Paroxysmal neurological manifestations: Panic attacks (1992) (0)
- P6263Phosphoinositide 3-kinase gamma inhibition protects against anthracycline-induced cardiomyopathy by boosting cardiac autophagy (2017) (0)
- PI3KC2α regulates cardiac contractility by restraining the β-adrenergic receptor/cyclic AMP (β-AR/cAMP) pathway (2022) (0)
- Implication du gène SRPX2 dans des pathologies de l’aire rolandique (2007) (0)
- The landscape of epilepsy-related GATOR1 variants (2018) (0)
- Beneficial effects of a cardiac gene therapy with phosphodiesterase pde2a in a mouse model of heart failure (2022) (0)
- Biallelic PDE2A Mutations: A New Cause of Intellectual Disability with Paroxysmal Dyskinesia and/or Epilepsy (2019) (0)
- Correction to: The landscape of epilepsy-related GATOR1 variants (2018) (0)
- [Ionic channels and epilepsy]. (2001) (0)
- Abstract LT018: The perivascular niche protects ALK+ lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis (2021) (0)
- 29 – Paroxysmal Dyskinesia (2007) (0)
- Epilepsy and neuroprotection: an illustrated review (Published with video sequences). (2002) (0)
- Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis (2018) (0)
- Genetic disruption of the Rac inhibitor ArhGAP15 leads to aortic valve disease in mice (2015) (0)
- PI3K γ AND PI3K δ : LINKERS OF COORDINATE C5aR-Fc γ R ACTIVATION AND IMMUNE COMPLEX-INDUCED INFLAMMATION * (2008) (0)
- Abstract 348: Genetic Disruption of the PI3 Kinase {gamma} Impairs Reparative Neovascularization of Ischemic Limb Muscles and Depresses the Functionality of Bone Marrow-Derived Progenitor Cells (2006) (0)
- Genetic analysis of beta1 integrin function (1997) (0)
- P624Genetic disruption of the Rac inhibitor ArhGAP15 leads to aortic valve disease in mice (2014) (0)
- OP13 – 2799: Landau-Kleffner syndrome (LKS), continuous spike and waves during slow-wave sleep syndrome (CSWSS), and Rolandic epilepsy (RE) – A genetic and immunological study (2015) (0)
- Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics (2018) (0)
- Non-Linear Reduction of Ion Currents in Cultured Cardiac Myocytes: Correlation with a Loss of T-Tubules? (2015) (0)
- 471 Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgamma inhibition (2020) (0)
- [Paroxysmal neurological manifestations disclosing panic attacks]. (1992) (0)
- [From historical EEG to signal treatment: applications in childhood epilepsy]. (2001) (0)
- Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications (2023) (0)
- Role of PI3K-gamma in ventilator induced lung injury (2004) (0)
- Role of PI3K gamma in beta-adrenergic stimulation of cardiac contractility and L-type calcium current (2002) (0)
- under Nontoxic Stress Condition MAPK Regulates IL-4 Production in BMMC Selective Activation of Fyn/PI3K and p38 (2013) (0)
- [Epilepsy, medical and nursing news]. (2018) (0)
- Expression of beta1 and alfa5 integrin genes (1990) (0)
- P359Inhibition of phosphoinositide 3-kinase gamma protects against chemotherapy-induced heart failure (2014) (0)
- Inhibition of phosphoinositide 3-kinase γ protects against chemotherapy-induced cardiomyopathy by promoting cardiac autophagy (2015) (0)
- 1093 The Absence of Functional PI3Kγ Has a Protective Effect On DSS-Induced Colitis in Mice (2009) (0)
- Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy (2022) (0)
- WS05.3 Characterisation of the molecular mechanisms underlying PI3Kγ-dependent stabilisation of CFTR at the plasma membrane (2020) (0)
- Benign neonatal familial convulsions: a model for the study of idiopathic epilepsies (2008) (0)
- Invasive EEG in Hypothalamic Hamartoma (2018) (0)
- Mast cell degranulation requires activation of PI3K γ by PKC β (2009) (0)
- Psoriasis-like Dermatitis Ameliorates Imiquimod-Induced Reduces IL-17 and γ or PI 3 K δ ( PI 3 K ) Blockade of Phosphatidylinositol 3-Kinase (2012) (0)
- Doxorubicin promotes a cardiac metabolic switch from an oxidative metabolism to glycolysis through a PI3Kγ-dependent mechanism (2022) (0)
- Non catalytic function of PI3KG on smooth muscle cells proliferation: A novel therapeutic strategy to prevent arterial remodeling through camp modulation. (2017) (0)
- Long-term Outcome in Neurozika: When Biological Diagnosis Matters (S45.008) (2019) (0)
- Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply (2016) (0)
- 300: Loss of PI3K-C2a promotes tumorigenesis and aneuploidy in breast cancer (2014) (0)
- Des pionniers de l'EEG au traitement du signal : application à l'exploration des épilepsies de l'enfant (2002) (0)
- Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth (2019) (0)
- Genetic generalized epilepsy and generalized onset seizures with focal evolution (GOFE) (2022) (0)
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What Schools Are Affiliated With Emilio Hirsch?
Emilio Hirsch is affiliated with the following schools: