Emilio Hirsch

Q: What Schools Are Affiliated With Emilio Hirsch

Emilio Hirsch is affiliated with the following schools: University of California, Berkeley, Paris-Saclay University, University of Bristol, University of Strasbourg, Stanford University, University of Bern, University of Turin, Maastricht University

Emilio Hirsch's AcademicInfluence.com Rankings

Emilio Hirsch

Computer Science

#4024

World Rank

#4231

Historical Rank

Computational Linguistics

#308

World Rank

#313

Historical Rank

Machine Learning

#667

World Rank

#677

Historical Rank

Artificial Intelligence

#869

World Rank

#885

Historical Rank

computer-science Degrees

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Computer Science

Emilio Hirsch's Degrees

PhD Computer Science Stanford University
Masters Computer Science University of California, Berkeley
Bachelors Computer Science University of California, Berkeley

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Emilio Hirsch's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology (2017) (2773)
Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology (2017) (1891)
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation (2000) (1168)
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. (1997) (1038)
PI3K/AKT signaling pathway and cancer: an updated review (2014) (869)
Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. (1997) (675)
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. (2000) (673)
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response (2002) (644)
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. (2000) (617)
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways (2002) (608)
Instruction manual for the ILAE 2017 operational classification of seizure types (2017) (606)
Nitric oxide synthase and neuronal vulnerability in parkinson's disease (1996) (589)
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis (2005) (556)
Neuroinflammatory processes in Parkinson's disease (2003) (522)
Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis (1991) (517)
PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects (2004) (478)
PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization (2004) (402)
Protective action of the peroxisome proliferator‐activated receptor‐γ agonist pioglitazone in a mouse model of Parkinson's disease (2002) (383)
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology (2011) (380)
GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction (2013) (365)
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate (2013) (360)
Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins (1996) (356)
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. (2011) (342)
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. (2005) (334)
Glial cells and inflammation in parkinson's disease: A role in neurodegeneration? (1998) (328)
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology (2009) (319)
Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions. (1998) (314)
Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload (2003) (303)
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (2016) (299)
Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. (1999) (297)
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development (2008) (292)
Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function (2002) (275)
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. (2004) (275)
Deep brain stimulation in epilepsy with particular reference to the subthalamic nucleus. (2002) (272)
SRPX2 mutations in disorders of language cortex and cognition. (2006) (253)
EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy (2001) (251)
Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis (2000) (249)
Skin wounds and severed nerves heal normally in mice lacking tenascin-C. (1996) (240)
Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. (2012) (231)
Landau‐Kleffner Syndrome: A Clinical and EEG Study of Five Cases (1990) (217)
Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content? (1992) (216)
Mutations of DEPDC5 cause autosomal dominant focal epilepsies (2013) (214)
Nocturnal Hypermotor Seizures, Suggesting Frontal Lobe Epilepsy, Can Originate in the Insula (2006) (207)
Landau‐Kleffner Syndrome: A Pharmacologic Study of Five Cases (1990) (203)
Crosslinking of α-synuclein by advanced glycation endproducts — an early pathophysiological step in Lewy body formation? (2000) (201)
Phosphoinositide 3-kinase signalling in the vascular system. (2008) (200)
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. (2016) (199)
Resistance to thromboembolism in PI3Kγ‐deficient mice (2001) (198)
Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK* (2000) (197)
Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements (2000) (196)
Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. (1999) (189)
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. (2011) (187)
Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases (2013) (183)
Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy (1995) (180)
Integrin signalling: the tug-of-war in heart hypertrophy. (2006) (178)
Neurocan Is Dispensable for Brain Development (2001) (175)
NADPH oxidases in heart failure: poachers or gamekeepers? (2013) (172)
PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function (2014) (169)
Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase1 (2005) (167)
An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease (1999) (167)
Antiepileptic Effect of High-frequency Stimulation of the Subthalamic Nucleus (Corpus Luysi) in a Case of Medically Intractable Epilepsy Caused by Focal Dysplasia: A 30-month Follow-up: Technical Case Report (2002) (165)
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer. (2015) (164)
Regional cerebral glucose metabolism in children with deterioration of one or more cognitive functions and continuous spike-and-wave discharges during sleep. (1995) (164)
Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ (2005) (160)
The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism (2003) (160)
Epileptic encephalopathies of the Landau‐Kleffner and continuous spike and waves during slow‐wave sleep types: Genomic dissection makes the link with autism (2012) (160)
Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. (1997) (159)
Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice (2004) (159)
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress (2007) (158)
Cognitive Development in Benign Focal Epilepsies of Childhood (1999) (158)
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence. (2004) (155)
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. (2008) (148)
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. (2007) (148)
PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis (2007) (147)
Methodology of photic stimulation revisited: Updated European algorithm for visual stimulation in the EEG laboratory (2012) (145)
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. (1999) (142)
New signal transduction paradigms in anthracycline-induced cardiotoxicity. (2016) (141)
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. (2007) (139)
Preservation of midbrain catecholaminergic neurons in very old human subjects. (2000) (138)
Are dopaminergic neurons selectively vulnerable to Parkinson's disease? (1993) (136)
Consensus on diagnosis and management of JME: From founder's observations to current trends (2013) (136)
Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. (2010) (135)
Genetic analyses of integrin function in mice. (1996) (135)
Lipids on the move: phosphoinositide 3-kinases in leukocyte function. (2000) (135)
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. (2002) (134)
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. (2009) (133)
Melusin Is a New Muscle-specific Interactor for β1Integrin Cytoplasmic Domain* (1999) (132)
Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats (1992) (131)
Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? (1990) (130)
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling (2015) (129)
Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-&ggr; Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes (2008) (128)
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. (2002) (127)
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. (2012) (126)
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation. (2007) (125)
PI3K inhibition in inflammation: Toward tailored therapies for specific diseases (2010) (125)
Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte. (1993) (124)
Regulating neutrophil apoptosis: new players enter the game. (2011) (123)
Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial‐onset seizures: A phase IIb, randomized, controlled trial (2013) (121)
Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy (2001) (121)
Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth (2018) (118)
Synaptic plasticity in the caudate nucleus of patients with Parkinson's disease. (1996) (114)
A Selective Role for Phosphatidylinositol 3,4,5-Trisphosphate in the Gi-dependent Activation of Platelet Rap1B* (2003) (111)
The landscape of epilepsy-related GATOR1 variants (2018) (110)
Contralateral disappearance of parkinsonian signs after subthalamic hematoma (1992) (108)
Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes? (2007) (106)
Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP? (1993) (106)
GRIN2A-related disorders: genotype and functional consequence predict phenotype (2018) (104)
Molecular networks implicated in speech-related disorders: FOXP2 regulates the SRPX2/uPAR complex. (2010) (104)
Cerebral Glucose Utilization During Sleep in Landau‐Kleffner Syndrome: A PET Study (1990) (103)
Involvement of Phosphoinositide 3-Kinase γ, Rac, and PAK Signaling in Chemokine-induced Macrophage Migration* (2004) (102)
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. (1997) (101)
The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC (2018) (101)
Crossroads of PI3K and Rac pathways (2015) (101)
Evidence for digenic inheritance in a family with both febrile convulsions and temporal lobe epilepsy implicating chromosomes 18qter and 1q25‐q31 (2001) (101)
Evaluation of brivaracetam, a novel SV2A ligand, in the photosensitivity model (2007) (99)
Resistance to thromboembolism in PI3Kgamma-deficient mice. (2001) (98)
Integrin function and regulation in development. (2000) (96)
Mesencephalic cholinergic nuclei in progressive supranuclear palsy (1991) (95)
Targeting myocardial remodelling to develop novel therapies for heart failure (2014) (94)
Targeting PI3K in Cancer: Any Good News? (2013) (94)
Plasma protein haptoglobin modulates renal iron loading. (2005) (93)
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. (2015) (93)
Optimizing therapy of seizures in patients with renal or hepatic dysfunction (2006) (93)
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion. (2007) (93)
Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum (1996) (92)
Genome-wide linkage scan of epilepsy-related photoparoxysmal electroencephalographic response: evidence for linkage on chromosomes 7q32 and 16p13. (2005) (92)
The amygdala is critical for seizure propagation from brainstem to forebrain (1997) (91)
Dominant partial epilepsies. A clinical, electrophysiological and genetic study of 19 European families. (2000) (91)
αv Integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development (1994) (91)
PI3Kγ Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells (2009) (90)
Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain (2002) (89)
Dopaminergic cell group A8 in the monkey: Anatomical organization and projections to the striatum (1999) (89)
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. (2005) (88)
Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1 (2003) (88)
PRRT2 links infantile convulsions and paroxysmal dyskinesia with migraine (2012) (87)
Inhibition of the substantia nigra suppresses absences and clonic seizures in audiogenic rats, but not tonic seizures: evidence for seizure specificity of the nigral control (2001) (86)
Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease. (1989) (85)
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration (2001) (84)
Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3 (2019) (84)
Classification of the epilepsies: New concepts for discussion and debate—Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology† (2016) (84)
Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion1 (2006) (83)
Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions (2007) (82)
From rolandic epilepsy to continuous spike‐and‐waves during sleep and Landau‐Kleffner syndromes: Insights into possible genetic factors (2009) (81)
An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology (2018) (81)
Risk factors of postictal generalized EEG suppression in generalized convulsive seizures (2015) (81)
Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation (2007) (80)
Involvement of Phosphoinositide 3-Kinase &ggr; in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice (2010) (80)
Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition1 (2007) (80)
Normal Skeletal Development of Mice Lacking Matrilin 1: Redundant Function of Matrilins in Cartilage? (1999) (80)
Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe (2016) (79)
Platelet Activation by von Willebrand Factor Requires Coordinated Signaling through Thromboxane A2 and FcγIIA Receptor* (2001) (79)
Superoxide dismutase and Parkinson's disease (1990) (78)
Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study. (1992) (77)
ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (77)
International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions (2022) (76)
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. (2011) (76)
Tremor‐related activity of neurons in the ‘motor’ thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism (2003) (76)
Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases (2005) (75)
Future prospects of brain stimlation (2000) (75)
Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep (2004) (74)
PI3K and Calcium Signaling in Cardiovascular Disease (2017) (74)
Phosphoinositide 3-Kinase &ggr; Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases (2012) (74)
Nonredundant role of CCRL2 in lung dendritic cell trafficking. (2010) (74)
Distribution of ataxin-7 in normal human brain and retina. (2000) (73)
Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2 (2019) (73)
Contractile Function During Angiotensin-II Activation (2015) (73)
Familial cortical myoclonic tremor with epilepsy (2010) (72)
Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease (1993) (72)
Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes (1996) (71)
A pro‐inflammatory signature mediates FGF2‐induced angiogenesis (2009) (71)
C-fos expression after single and kindled audiogenic seizures in Wistar rats (1994) (71)
Blockade of Phosphatidylinositol 3-Kinase (PI3K)δ or PI3Kγ Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis (2012) (70)
Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio1 (2003) (70)
Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: Dose-dependent effects in the human photosensitivity model (2013) (70)
Epilepsy, antiepileptic drugs (AEDs) and cognition (2003) (70)
Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection (2007) (68)
Anchoring Proteins as Regulators of Signaling Pathways (2012) (68)
Integrin subunit expression associated with epithelial‐mesenchymal interactions during murine tooth development (1996) (68)
The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role? (1990) (67)
Cost‐effectiveness analysis of epilepsy surgery in a controlled cohort of adult patients with intractable partial epilepsy: A 5‐year follow‐up study (2016) (67)
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues. (2010) (67)
The novel butyrate derivative phenylalanine‐butyramide protects from doxorubicin‐induced cardiotoxicity (2019) (67)
FADD: A link between TNF family receptors and caspases in Parkinson’s disease (2002) (67)
Class II PI3K Functions in Cell Biology and Disease. (2019) (67)
Twice upon a time: PI3K's secret double life exposed. (2009) (66)
A subset of genomic alterations detected in rolandic epilepsies contains candidate or known epilepsy genes including GRIN2A and PRRT2 (2014) (66)
The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation (2010) (66)
Electroclinical signs of benign neonatal familial convulsions (1993) (66)
Immunocytochemical Quantification of Tyrosine Hydroxylase at a Cellular Level in the Mesencephalon of Control Subjects and Patients with Parkinson's and Alzheimer's Disease (1993) (65)
Effects of Nigrostriatal Denervation and L‐Dopa Therapy on the GABAergic Neurons of the Striatum in MPTP‐treated Monkeys and Parkinson's Disease: An In Situ Hybridization Study of GAD67 mRNA (1995) (64)
PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. (2011) (64)
Correlation between PET and SISCOM in temporal lobe epilepsy. (2002) (64)
Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis (2013) (63)
Distribution of manganese-dependent superoxide dismutase in the human brain (1994) (63)
Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery (2016) (62)
Current standards of neuropsychological assessment in epilepsy surgery centers across Europe (2017) (62)
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control (2013) (62)
Signaling through PI3Kγ: a common platform for leukocyte, platelet and cardiovascular stress sensing (2005) (62)
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis (2018) (62)
Leukocyte transmigration is modulated by chemokine‐mediated PI3Kγ‐dependent phosphorylation of vimentin (2009) (62)
A Single Cis-acting Element in a Short Promoter Segment of the Gene Encoding the Interphotoreceptor Retinoid-binding Protein Confers Tissue-specific Expression (*) (1995) (62)
Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture. (2004) (62)
Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines (2011) (62)
S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase. (1999) (61)
Present and future of PI3K pathway inhibition in cancer: perspectives and limitations. (2011) (61)
Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. (2010) (61)
Taming the PI3K team to hold inflammation and cancer at bay. (2008) (61)
Myocyte signalling in leucocyte recruitment to the heart. (2014) (60)
Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality? (2009) (60)
PI3K in cancer–stroma interactions: bad in seed and ugly in soil (2014) (59)
Tumor-Derived Prostaglandin E2 Promotes p50 NF-κB-Dependent Differentiation of Monocytic MDSCs (2020) (59)
Liver X Receptor Activation Reduces Angiogenesis by Impairing Lipid Raft Localization and Signaling of Vascular Endothelial Growth Factor Receptor-2 (2012) (59)
Alterations of GABAergic neurons in the basal ganglia of patients with progressive supranuclear palsy (1995) (59)
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes (2018) (59)
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ (2007) (59)
Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: A post mortem in situ hybridization study with special reference to Parkinson's disease (2005) (58)
Idiopathic Rolandic Epilepsy with “Interictal” Facial Myoclonia and Oromotor Deficit: A Longitudinal EEG and PET Study (1999) (58)
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function. (2017) (58)
Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase &ggr; Activity in Pressure Overload–Induced Cardiac Failure (2011) (57)
Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. (2003) (57)
Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU (2017) (57)
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility (2010) (57)
Phosphoinositide 3‐kinase gamma; participates in T cell receptor‐induced T cell activation. (2008) (57)
PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth (2013) (57)
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. (2008) (57)
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling. (2012) (56)
Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury (2006) (56)
γ-Hydroxybutyric acid induced spike and wave discharges in rats: Relation to high-affinity [3H]γ-hydroxybutyric acid binding sites in the thalamus and cortex (1993) (55)
CHF6001 I: A Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-Inflammatory Activity and Suitable for Topical Pulmonary Administration (2015) (55)
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. (2003) (55)
Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: Analysis of two randomized, double-blind, placebo-controlled studies (2009) (55)
Distribution of 125I‐Ferrotransferrin Binding Sites in the Mesencephalon of Control Subjects and Patients with Parkinson's Disease (1993) (55)
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities (2018) (55)
Mouse myoblasts can fuse and form a normal sarcomere in the absence of beta1 integrin expression. (1998) (55)
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. (2010) (54)
PI3K kinase and scaffold functions in heart (2010) (53)
GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys (1993) (53)
Loss of PI3K&ggr; Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress (2010) (53)
Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking. (2017) (52)
Epidemiology of epilepsy. (2016) (52)
Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. (2018) (51)
Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer? (2020) (50)
Epileptogenic networks in nodular heterotopia: A stereoelectroencephalography study (2017) (50)
Targeting PI3K signaling in cancer: Challenges and advances. (2019) (49)
Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP–intoxicated monkeys: Effect of levodopa and GM1 ganglioside therapy (1994) (49)
Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease (2015) (49)
Green fluorescent protein as a reporter of gene expression in transgenic mice. (1997) (49)
Epilepsy and neuroprotection: an illustrated review. (2002) (48)
Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. (2014) (48)
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. (2008) (48)
PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. (2012) (47)
Neuronal localization of copper-zinc superoxide dismutase protein and mRNA within the human hippocampus from control and Alzheimer's disease brains. (1991) (47)
The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions. (2011) (47)
Nocturnal paroxysmal dystonia: a clinical form of focal epilepsy (1994) (46)
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. (2007) (46)
ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (46)
LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa‐induced motor alterations in Parkinsonian rats (2001) (46)
Does loss of nerve growth factor receptors precede loss of cholinergic neurons in Alzheimer's disease? An autoradiographic study in the human striatum and basal forebrain (1992) (46)
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress (2020) (45)
Effects of L-DOPA-therapy on dopamine D2 receptor mRNA expression in the striatum of MPTP-intoxicated parkinsonian monkeys. (1996) (45)
Landau–Kleffner syndrome: sleep EEG characteristics at onset (2000) (45)
Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. (2020) (45)
Progressive supranuclear palsy (1991) (44)
Seizures and the basal ganglia: a review of the clinical data. (2002) (43)
Contribution of SISCOM Imaging in the Presurgical Evaluation of Temporal Lobe Epilepsy Related to Dysembryoplastic Neuroepithelial Tumors (2002) (43)
Lack of phosphoinositide 3-kinase-&ggr; attenuates ventilator-induced lung injury* (2006) (43)
Tyrosine kinase B messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study (1998) (43)
Tumour biology. Weakening link to colorectal cancer (2001) (43)
Ablation of Phosphoinositide 3-Kinase-γ Reduces the Severity of Acute Pancreatitis (2004) (42)
Novel mutations in EPM2A and NHLRC1 widen the spectrum of Lafora disease (2010) (42)
Targeting phosphoinositide 3-kinase γ to fight inflammation and more (2008) (42)
Phosphoinositide 3-Kinases γ and δ, Linkers of Coordinate C5a Receptor-Fcγ Receptor Activation and Immune Complex-induced Inflammation* (2008) (42)
Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study. (2000) (41)
PI3K keeps the balance between metabolism and cancer. (2012) (41)
Semiology of typical and atypical Rolandic epilepsy: a video-EEG analysis. (2002) (41)
Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation. (2016) (41)
Long‐term outcome after cognitive and behavioral regression in nonlesional epilepsy with continuous spike‐waves during slow‐wave sleep (2012) (41)
Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease. (1997) (40)
Tyrosine kinase Btk regulates E-selectin–mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) (cid:1) 2 and PI3K (cid:1) pathways (2010) (40)
Hypothalamic hamartoma: Epileptogenesis beyond the lesion? (2017) (40)
Inhibition of neutrophil migration by hemopexin leads to increased mortality due to sepsis in mice. (2011) (39)
Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking (2019) (39)
Eyelid fluttering, typical EEG pattern, and impaired intellectual function: A homogeneous epileptic condition among the patients presenting with eyelid myoclonia (2009) (39)
Combined Measurements of Hippocampal N‐Acetyl‐Aspartate and T2 Relaxation Time in the Evaluation of Mesial Temporal Lobe Epilepsy: Correlation with Clinical Severity and Memory Performances (1999) (39)
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. (2014) (39)
Epilepsies and video games: results of a multicentric study. (1998) (39)
Integrating Cardiac PIP 3 and cAMP Signaling through a PKA Anchoring Function of p 110 g (39)
Catecholaminergic systems in the medulla oblongata in parkinsonian syndromes (1990) (38)
Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: An exploratory, placebo-controlled study (2007) (38)
A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation. (2012) (37)
Heterogeneity and frequency of movement disorders in juvenile and adult-onset Niemann-Pick C disease (2013) (37)
Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions. (2003) (37)
Intracranial electrodes in the presurgical evaluation of epilepsy (2012) (36)
Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer (2021) (36)
PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway (2010) (36)
Autoradiographic localization and density of [125I]ferrotransferrin binding sites in the basal ganglia of control subjects, patients with Parkinson's disease and MPTP-lesioned monkeys (1995) (36)
Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells (2014) (36)
Hypothalamic hamartoma: Is the epileptogenic zone always hypothalamic? Arguments for independent (third stage) secondary epileptogenesis (2013) (36)
Phosphoinositide 3-kinase γ : kinase-dependent and -independent activities in cardiovascular function and disease (2004) (36)
The PI3K/Akt/mTOR pathway in polycystic kidney disease: A complex interaction with polycystins and primary cilium. (2019) (36)
Preventing and Treating Anthracycline Cardiotoxicity: New Insights. (2020) (36)
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH–dependent sympathetic drive (2014) (36)
Hemopexin counteracts systolic dysfunction induced by heme‐driven oxidative stress (2017) (36)
Outcome of childhood-onset epilepsy from adolescence to adulthood: Transition issues (2017) (35)
Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression (2018) (35)
Landau–Kleffner syndrome is not an eponymic badge of ignorance (2006) (35)
Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation (2013) (35)
PI(3,4)P2 Signaling in Cancer and Metabolism (2020) (35)
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development. (1994) (35)
PI3K‐C2α: One enzyme for two products coupling vesicle trafficking and signal transduction (2015) (35)
Clinical and pathological features in hydrocarbon‐induced Parkinsonism (1996) (35)
International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions (2022) (34)
Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats (1992) (34)
Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema (2010) (34)
Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction (2018) (34)
Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice. (1996) (34)
Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl (2002) (33)
PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts (2017) (33)
Role of pontine nuclei damage in smooth pursuit impairment of progressive supranuclear palsy (1994) (33)
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure (2020) (33)
Neural responses associated with positive and negative emotion processing in patients with left versus right temporal lobe epilepsy (2006) (33)
Genetic analysis of β 1 integrin function : confirmed , new and revised roles for a crucial family of cell adhesion molecules (1997) (33)
The influence of seizure frequency on anterograde and remote memory in mesial temporal lobe epilepsy (2014) (33)
Antiepileptic Drug-Induced Pharmacodynamic Aggravation of Seizures (2003) (33)
Neurologic presentations of renal diseases. (2010) (32)
Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling (2015) (32)
Subtraction ictal SPECT co-registered to MRI (SISCOM) in Sturge-Weber syndrome. (2005) (32)
PI3K p110γ Deletion Attenuates Murine Atherosclerosis by Reducing Macrophage Proliferation but Not Polarization or Apoptosis in Lesions (2013) (32)
The proline‐rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside‐in signaling (2013) (32)
Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. (2004) (31)
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development. (2015) (31)
[Neuronal death caused by apoptosis in Parkinson disease]. (1997) (31)
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy. (2013) (31)
Selective amygdalohippocampectomy versus standard temporal lobectomy in patients with mesiotemporal lobe epilepsy and unilateral hippocampal sclerosis: post-operative facial emotion recognition abilities (2015) (31)
Changes in GAD67 mRNA expression evidenced by in situ hybridization in the brain of R6/2 transgenic mice (2003) (30)
Phosphoinositide 3‐kinase γ controls autonomic regulation of the mouse heart through Gi‐independent downregulation of cAMP level (2005) (30)
Loss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy (2016) (29)
Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response. (2019) (29)
The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. (2010) (29)
Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. (2020) (29)
Phosphoinositide 3‐kinase p110γ in immunity (2011) (29)
Neuromelanin accumulation with age in catecholaminergic neurons from Macaca fascicularis brainstem. (1993) (29)
The indirect basal ganglia pathway in dopamine D2 receptor-deficient mice (2000) (29)
Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions (2022) (29)
Essential role of phosphoinositide 3‐kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation (2009) (28)
Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures. (2004) (28)
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. (2003) (28)
Expression of 1 integrin complexes on the surface of unfertilized mouse oocyte (28)
Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease (2021) (28)
Co‐Occurrence of infantile epileptic seizures and childhood paroxysmal choreoathetosis in one family: Clinical, EEG, and SPECT characterization of episodic events (2002) (27)
Therapeutic applications of PI3K inhibitors in cardiovascular diseases. (2013) (27)
Short-interval amygdala kindling in neonatal rats. (1993) (27)
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits (2016) (27)
Functions of PDE3 Isoforms in Cardiac Muscle (2018) (27)
SPM analysis of ictal–interictal SPECT in mesial temporal lobe epilepsy: Relationships between ictal semiology and perfusion changes (2009) (26)
The ideal characteristics of antiepileptic therapy: an overview of old and new AEDs (2003) (26)
Lupus Anticoagulant Induced by the Combination of Valproate and Lamotrigine (1999) (26)
Signaling pathways underlying anthracycline cardiotoxicity. (2020) (26)
Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology. (2013) (26)
trkB messenger RNA expression in normal human brain and in the substantia nigra of parkinsonian patients: an in situ hybridization study. (1998) (26)
PI3K signaling in the pathogenesis of obesity: The cause and the cure. (2015) (26)
Update on the genetics of the epilepsy-aphasia spectrum and role of GRIN2A mutations. (2019) (26)
KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP. (2019) (26)
PI3Ks and small GTPases in neutrophil migration: two sides of the same coin. (2013) (26)
Phosphoinositide 3‐kinaseγ (PI3Kγ) controls L‐type calcium current (ICa,L) through its positive modulation of type‐3 phosphodiesterase (PDE3) (2006) (25)
Hypoxemia following generalized convulsive seizures (2019) (25)
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response (2014) (25)
Pharmacologic Inhibition of Phosphoinositide 3-Kinase Gamma (PI3Kγ) Promotes Infarct Resorption and Prevents Adverse Cardiac Remodeling After Myocardial Infarction in Mice (2010) (24)
Glutamic acid decarboxylase mRNA expression in medial and lateral pallidal neurons in the MPTP-treated monkey and patients with Parkinson's disease. (1996) (24)
Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics (2018) (24)
Construction of a Global Pain Systems Network Highlights Phospholipid Signaling as a Regulator of Heat Nociception (2012) (24)
Morgana acts as an oncosuppressor in chronic myeloid leukemia. (2015) (24)
Phosphoinositide 3-kinases in health and disease. (2012) (24)
Tyrosine hydroxylase gene expression in human ventral mesencephalon: Detection of tyrosine hydroxylase messenger RNA in neurites (1990) (23)
Efficacy and safety in frameless robot-assisted stereo-electroencephalography (SEEG) for drug-resistant epilepsy. (2017) (23)
Galanin pathogenic mutations in temporal lobe epilepsy. (2015) (23)
Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (23)
Differential vulnerability to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of dopaminergic and cholinergic neurons in the monkey mesopontine tegmentum (1993) (23)
Dichotic listening performances in the follow-up of Landau and Kleffner syndrome (1997) (23)
Contribution of T2Relaxation Time Mapping in the Evaluation of Cryptogenic Temporal Lobe Epilepsy (1998) (23)
Mutations in the Novel Protein PRRT2 Cause Infantile Convulsions with Paroxysmal Kinesigenic Dyskinesia (2012) (23)
[Cognitive consequences of Rolandic Epilepsy]. (2001) (23)
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 (2018) (22)
[Cost-effectiveness of epilepsy surgery in a cohort of patients with medically intractable partial epilepsy--preliminary results]. (2004) (22)
p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity (2019) (22)
Basal ganglia involvement in rotational seizures. (1999) (22)
Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential. (2008) (22)
CC-Chemokine Ligand 16 Induces a Novel Maturation Program in Human Immature Monocyte-Derived Dendritic Cells1 (2006) (22)
Postencephalitic stereotyped involuntary movements responsive to L‐Dopa (1996) (21)
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl. (2015) (21)
New Insights into the Clinical Management of Partial Epilepsies (2000) (21)
KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum. (2021) (21)
Key role of PI3Kγ in monocyte chemotactic protein‐1‐mediated amplification of PDGF‐induced aortic smooth muscle cell migration (2012) (21)
More than just kinases: the scaffolding function of PI3K. (2010) (21)
Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling. (2015) (20)
Visual and auditory socio-cognitive perception in unilateral temporal lobe epilepsy in children and adolescents: a prospective controlled study. (2014) (20)
Reciprocal positive transfer between kindling of audiogenic seizures and electrical kindling of inferior colliculus (1993) (20)
Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia (2016) (20)
Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2–2q11.2 (2016) (20)
The RhoA‐associated protein Citron‐N controls dendritic spine maintenance by interacting with spine‐associated Golgi compartments (2008) (20)
PI3Kγ integrates cAMP and Akt signalling of the μ‐opioid receptor (2014) (20)
Mild malformations of cortical development in sleep‐related hypermotor epilepsy due to KCNT1 mutations (2018) (20)
Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ−/− mice causes alveolar macrophage deficiency and fatal respiratory viral infection (2017) (19)
Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting (2018) (19)
Modulation of μ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ (2010) (19)
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation (2021) (19)
Specific PI3K Isoform Modulation in Heart Failure: Lessons from Transgenic Mice (2011) (18)
Epilepsy and Videogames (2004) (18)
Benign childhood epilepsy with centrotemporal spikes: Is it always benign? (2000) (18)
Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. (2004) (18)
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. (2015) (18)
Phosphoinositide 3-kinasegamma (PI3Kgamma) controls L-type calcium current (ICa,L) through its positive modulation of type-3 phosphodiesterase (PDE3). (2006) (18)
Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure. (2014) (18)
Analysis of the murine phosphoinositide 3-kinase γ gene (2000) (17)
Summary PTX 3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization (2004) (17)
Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases* (2012) (17)
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis (2018) (17)
Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia (2020) (17)
Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months (2016) (16)
Angiogenesis in metabolic-vascular disease (2017) (16)
Increase of valproate‐induced hyperammonemia in normal subjects by carbohydrate intake (1984) (16)
[Parkinson disease: mechanisms of cell death]. (2002) (16)
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions (2010) (16)
New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole. (2019) (16)
Pure endoscopic management of epileptogenic hypothalamic hamartomas (2017) (16)
Levetiracetam: preliminary efficacy in generalized seizures. (2003) (16)
gamma-Hydroxybutyric acid induced spike and wave discharges in rats: relation to high-affinity [3H]gamma-hydroxybutyric acid binding sites in the thalamus and cortex. (1993) (16)
Selective memory impairment for public events in a patient with left temporal lobe epilepsy (2005) (15)
The beta 1 integrin distal promoter is developmentally regulated in transgenic mice. (1993) (15)
Landau–Kleffner syndrome: a rare childhood epileptic aphasia (1999) (15)
Metabolomic characterization of human hippocampus from drug‐resistant epilepsy with mesial temporal seizure (2018) (15)
Dramatic changes in artistic preference after left temporal lobectomy (2003) (14)
Operationale Klassifikation der Anfallsformen durch die Internationale Liga gegen Epilepsie: Positionspapier der ILAE-Klassifikations- und Terminologiekommission (2018) (14)
Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease (2015) (14)
Rac signal adaptation controls neutrophil mobilization from the bone marrow (2016) (14)
Late onset heart failure after childhood chemotherapy. (2019) (14)
Long-term outcome in neuroZika (2019) (14)
Language‐induced Epilepsy, Acquired Stuttering, and Idiopathic Generalized Epilepsy: Phenotypic Study of One Family (2006) (14)
Methods to measure the enzymatic activity of PI3Ks. (2014) (14)
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors. (2011) (14)
Ciliary Neurotrophic Factor Constitutively Expressed in the Nervous System of Transgenic Mice Protects Embryonic Dorsal Root Ganglion Neurons from Apoptosis (1996) (14)
How PI3K-derived lipids control cell division (2015) (14)
ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models (2014) (14)
The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation. (2015) (13)
PET follow-up in a case of anti-NMDAR encephalitis: arguments for cingulate limbic encephalitis (2012) (13)
Contractile Function During Angiotensin-II Activation Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban (13)
Adjunctive antiepileptic drugs in adult epilepsy: how the first add-on could be the last (2010) (13)
Dorsal tegmentum kindling in rats (1992) (13)
Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs (2017) (13)
Focal epilepsy in SCN1A‐mutation carrying patients: is there a role for epilepsy surgery? (2020) (12)
The Inhibition of Phosphoinositide-3 Kinases Induce Resolution of Inflammation in a Gout Model (2019) (12)
Gangliosides and parkinsonism (1993) (12)
Mechanisms underlying the cross‐talk between heart and cancer (2020) (12)
Cytokinetic Abscission: Phosphoinositides and ESCRTs Direct the Final Cut (2017) (12)
Phosphoinositides in cell proliferation and metabolism. (2020) (12)
A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials (2021) (12)
Antiglial Cell Autoantibodies and Childhood Epilepsy: A Case Report (2005) (12)
Pathophysiological aspects of Landau-Kleffner syndrome: from the active epileptic phase to recovery. (2001) (11)
High affinity neurotrophin receptors in cholinergic neurons in the human brain. (1994) (11)
Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. (2014) (11)
The Anaplastic Lymphoma Kinase Controls Cell Shape and Growth of Anaplastic Large Cell Lymphoma through Cdc 42 Activation (2008) (11)
CACNA1A-associated epilepsy: Electroclinical findings and treatment response on seizures in 18 patients. (2021) (11)
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia (2022) (11)
[Children with drug-resistant partial epilepsy: criteria for the identification of surgical candidates]. (2004) (11)
Exome sequencing in 57 patients with self-limited focal epilepsies of childhood with typical or atypical presentations suggests novel candidate genes. (2020) (10)
Analysis of the murine phosphoinositide 3-kinase gamma gene. (2000) (10)
Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth (2019) (10)
Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (2016) (10)
PI3Kγ Inhibition Protects Against Diabetic Cardiomyopathy in Mice. (2017) (10)
High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia (2019) (10)
PI3K Signaling in Mechanisms and Treatments of Pulmonary Fibrosis Following Sepsis and Acute Lung Injury (2022) (10)
[Autosomal dominant nocturnal frontal lobe epilepsy]. (1998) (9)
Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures (2018) (9)
Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply (2016) (9)
2017 International League Against Epilepsy classifications of seizures and epilepsy are steps in the right direction (2019) (9)
Peri-Implantation Lethality in Mice Lacking the Sm Motif-Containing Protein Lsm4 (2000) (9)
Targeting the Extracellular HSP90 Co-Chaperone Morgana Inhibits Cancer Cell Migration and Promotes Anticancer Immunity (2021) (9)
Inhalation of the prodrug PI 3 K inhibitor CL 27 c improves lung function in asthma and fi brosis (2018) (9)
Generalized seizures : from clinical phenomenology to underlying systems and networks /Edouard Hirsch ...[et al.] (2006) (9)
Data demonstrating the anti-oxidant role of hemopexin in the heart (2017) (9)
Regional and cellular presenilin 2 (STM2) gene expression in the human brain. (1996) (9)
Contribution of T2 relaxation time mapping in the evaluation of cryptogenic temporal lobe epilepsy. (1998) (9)
The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. (2014) (9)
Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia (2017) (9)
Loss of β1-integrin-deficient cells during the development of endoderm-derived epithelia (2003) (8)
Non-linear analysis of epileptic seizures I. Correlation-dimension measurements for absence epilepsy and near-periodic signals (1999) (8)
PI3Ks in Diabetic Cardiomyopathy (2017) (8)
Hypermetabolism during resting-state FDG-PET suggesting intrinsic epileptogenicity in focal cortical dysplasia. (2014) (8)
[Autoimmune encephalitis, clinical, radiological and immunological data]. (2013) (8)
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-α and Tfr2-β isoforms in different tissues (8)
Therapeutic peptides for the treatment of cystic fibrosis: Challenges and perspectives. (2021) (7)
Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage (2019) (7)
Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy. (2017) (7)
Can histologically normal epileptogenic zone share common electrophysiological phenotypes with focal cortical dysplasia? SEEG-based study in MRI-negative epileptic patients (2019) (7)
Corpus callosotomy in the lithium-pilocarpine model of seizures and status epilepticus (1992) (7)
Impairment in auditory verbal processing and dichotic listening after recovery of epilepsy in Landau and Kleffner Syndrome (1999) (7)
Inactivation of PI3K (cid:1) and PI3K (cid:2) distorts T-cell development and causes multiple organ inﬂammation (2007) (7)
Erratum to: Regulating neutrophil apoptosis: new players enter the game [Trends in Immunology (2011) 32, 117–124] (2011) (7)
Overlapping and distinct roles for PI 3 K b and g isoforms in S 1 P-induced migration of human and mouse endothelial cells (2008) (7)
Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure. (2010) (6)
Early dissociation of verbal and nonverbal gestural ability in an epileptic deaf child (1999) (6)
Measuring PI3K lipid kinase activity. (2012) (6)
Epileptic encephalopathy with continuous spike‐waves during sleep: The need for transition from childhood to adulthood medical care appears to be related to etiology (2014) (6)
Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims (2008) (6)
Protective Role of the M-Sec–Tunneling Nanotube System in Podocytes (2021) (6)
Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels. (2006) (6)
Tumour biology (Communication arising): Weakening link to colorectal cancer? (2001) (6)
Magnetically enriched bone marrow‐derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice (2008) (6)
Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases (2021) (6)
Isotope tracer-techniques in rolandic epilepsy and its variants. (2001) (6)
Correction: The landscape of epilepsy-related GATOR1 variants (2018) (6)
Cancer: Natural-born killers unleashed (2014) (6)
[Benign familial neonatal convulsions: a model of idiopathic epilepsy]. (1999) (6)
Structural basis of phosphatidylinositol 3-kinase C2α function (2022) (6)
Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial (2016) (6)
PI 3 KC 2 a : One enzyme for two products coupling vesicle trafficking and signal transduction (2015) (6)
[Postures and abnormal paroxysmal movements during sleep: hypnogenic paroxysmal dystonia or partial epilepsy?]. (1991) (6)
[Selective memory impairment for public events associated with accelerated forgetting in a patient with left temporal lobe epilepsy]. (2006) (6)
Role of Protein Kinase A-Mediated Phosphorylation in CFTR Channel Activity Regulation (2021) (5)
Short Interval Electrical Amygdala Kindling in Infant Rats (1998) (5)
Phosphoinositides and cardiovascular diseases. (2012) (5)
Physics of compartmentalization: How phase separation and signaling shape membrane and organelle identity (2021) (5)
Comment from Dorothée G.A. Kasteleijn-Nolst Trenité, Edouard Hirsch, Ronald C. Reed, Bassel Abou-Khalil, and Bernd Schmidt on: How predictive are photosensitive epilepsy models as proof of principle trials for epilepsy? (2014) (5)
Post-Wortmannin Era: Novel Phosphoinositide 3-Kinase Inhibitors with Potential Therapeutic Applications (2009) (5)
DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls. (2019) (5)
Calming down T cell acute leukemia. (2012) (5)
Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (5)
Preserved anterograde and remote memory in drug-responsive temporal lobe epileptic patients (2015) (5)
Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study (2019) (5)
[Medicoeconomic assessment of epilepsy surgery in adults with medically intractable partial epilepsy. Three-year outcomes from a multicenter French cohort]. (2008) (5)
Corrigendum: A selective inhibitor reveals PI3Kγ dependence of T H 17 cell differentiation (2012) (5)
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice (2011) (5)
Ultrastructural relations between nigrostriatal dopaminergic neurons and cholinergic nerve endings in the human brain. (1993) (5)
Encephalopathy related to Status Epilepticus during slow Sleep: from concepts to terminology. (2019) (5)
[Parkinson's disease: cell death mechanisms] (2002) (5)
Analysis of regulatory regions of the ciliary neurotrophic factor gene in transgenic mice (1995) (5)
Aging, disease and death of nerve cells. (1996) (5)
Comparison of Functional Deficit Zone Defined by FDG PET to the Epileptogenic Zones Described in Stereo-Electroencephalograph in Drug-Resistant Epileptic Patients Treated by Surgery. (2019) (5)
A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage (2020) (4)
Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis. (2014) (4)
Isolated paroxysmal arousals as focal epilepsy. (2006) (4)
Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF) (2017) (4)
Misleading features of neuroimaging and electroencephalography: insulinoma misdiagnosed as temporal lobe epilepsy (2013) (4)
Section of the corpus callosum in kainic acid induced seizures in rats: behavioral, electroencephalographic and neuropathological study (1992) (4)
Decrease of valproate-induced hyperammonemia in normal subjects by lipid ingestion (1985) (4)
[Basal ganglia deep-brain stimulation for treatment of drug-resistant epilepsy: review and current data]. (2008) (4)
IMPACT OF P-GLYCOPROTEIN ON THE DISTRIBUTION OF [F-18] MPPF IN PHARMACORESISTANT TEMPORAL LOBE EPILEPSY (2010) (4)
Nocturnal paroxysmal dystonia. (1993) (4)
Corrigendum to: Integrin signalling: The tug-of-war in heart hypertrophy [Cardiovascular Research 70 (2006) 422–433] (2006) (4)
Towards a definition of the "practical" epileptogenic zone: a case of epilepsy with dual pathology. (2006) (4)
Genetic Evidence for a Predominant Role of PI3Kβ In ITAM— and Integrin-Mediated Signaling in Platelets (2008) (4)
ArhGAP15, a RacGAP, Acts as a Temporal Signaling Regulator of Mac-1 Affinity in Sterile Inflammation (2020) (4)
Tissue-specific KO of ECM proteins. (2009) (4)
Adrenal transplant, dopaminergic neurons, and Parkinson' disease (1993) (4)
[Should new generation antiepileptic drugs be prescribed as first-line treatment of newly diagnosed epilepsy in adolescents and adults?]. (2003) (4)
Requirement for PI 3-kinase g in macrophage migration (2003) (3)
Childhood epilepsy syndromes with both focal and generalized seizures (2005) (3)
[Diurnal and nocturnal paroxysmal dyskinesia in young children: a new entity?]. (1997) (3)
Key role of PI 3 K g in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration (2012) (3)
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors (2015) (3)
PI3K as Mediator of Apoptosis and Contractile Dysfunction in TGFβ1-Stimulated Cardiomyocytes (2021) (3)
Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer (2022) (3)
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer (2022) (3)
Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis. (2015) (3)
Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy (2021) (3)
Characterization of the beta1 integrin gene promoter (1992) (3)
Use of suggestive seizure manipulation methods in the investigation of patients with possible psychogenic nonepileptic seizures—An international ILAE survey (2021) (3)
Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype? (2017) (3)
Classification as autonomic versus sensory seizures (2019) (3)
[Epilepsy surgery in children: from a multidisciplinary network to the creation of an expertise and care centre]. (2008) (2)
Chatting Second Messengers: PIP3 and cAMP (2017) (2)
Three Different FDG Patterns in Periventricular Nodular Heterotopia Correlated to Video Stereoelectroencephalography. (2021) (2)
Other Probable Syndromes of Idiopathic Generalized Epilepsies (2010) (2)
Statistical Kernel-based Modeling of Connectomes (2012) (2)
p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation (2016) (2)
[Refractory partial epilepsy: what are the neuropediatrician's criteria for drug resistance?]. (2004) (2)
Edinburgh Research Explorer Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions (2018) (2)
'Circulating' RNA-based therapies in Cardio-Oncology. (2022) (2)
Predictive factors of epilepsy in arteriovenous malformation (2020) (2)
Potential therapeutic applications of AKAP disrupting peptides. (2020) (2)
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy (2022) (2)
[An atypical form of neurosarcoidosis]. (2013) (2)
Electroconvulsive therapy for psychosis in a patient with epilepsy related to hypothalamic hamartoma (2013) (2)
Phosphoinositide-3 kinase gamma kinase activity significantly contributes to the pathophysiology of sepsis and multiorgan failure (2008) (2)
Two signalling hands for uPAR (2013) (2)
SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution (2020) (2)
Monocyte-Derived Dendritic Cells Maturation Program in Human Immature CC-Chemokine Ligand 16 Induces a Novel (2006) (2)
[Memory improvement in patients with temporal lobe epilepsy at one-year postoperative]. (2011) (2)
PI3K signaling: a crossroads of metabolic regulation (2009) (2)
Inflaming attraction by RNA (2012) (1)
TRANSITORY COGNITIVE DISORDERS AND LEARNING IMPAIRMENT (2001) (1)
COMMENTARY Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules (1997) (1)
Inhibitory role of the acute phase proteins on neutrophil migration in severe sepsis (2009) (1)
Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance (2021) (1)
Commentary on the usefulness of a morning routine EEG recording in patients with juvenile myoclonic epilepsy (2008) (1)
Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. (2021) (1)
P1938In vitro characterization of a novel PI 3-kinase inhibitor for growth factor-induced effects in pulmonary artery smooth muscle cells (2019) (1)
Oxidative stress in anticancer therapies-related cardiac dysfunction. (2021) (1)
Signal transduction in inflammation (2005) (1)
Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation (2022) (1)
Noncatalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage. (2020) (1)
Abstract 21531: Inducible Kinase-Independent Effects of Phosphoinositide-3-Kinase Gamma on Cardiac Contractility (2010) (1)
PHOSPHOINOSITIDE-3 KINASE GAMMA ACTIVITY CONTRIBUTES TO BACTERIAL DISSEMINATION DURING ABDOMINAL SEPSIS (2009) (1)
Choline-acetyltransferase immunoreactivity in the hippocampal formation of control subjects and in patients with Alzheimer's disease (1989) (1)
Epilepsy and neuroprotection (2002) (1)
Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU (2017) (1)
[Fits, faints and blackouts in the adult]. (2003) (1)
[Is there a bridge between migraine and familial mesial temporal lobe epilepsy?]. (2009) (1)
EEG in fitness to drive evaluations in people with epilepsy — Considerable variations across Europe (2020) (1)
Epileptic syndromes with focal seizures of childhood and adolescence. (2012) (1)
Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular traf ﬁ cking Advances in Biological Regulation (1)
The turtle and the rabbit story in a modern (PI3)key (2018) (1)
PI3Kγ inhibition protects from anthracycline-induced heart failure and reduces tumor growth (2018) (1)
Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (1)
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases (2022) (1)
Announcement: Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure (2013) (1)
Tumor biology: mouse models of colon cancer (2001) (1)
Vagus nerve stimulation in epilepsy: Efficiency and safety of outpatient practice. (2020) (1)
Phosphoproteomics identifies PI3K inhibitor-selective adaptive responses in pancreatic cancer cell therapy and resistance (2020) (1)
Correction to: The landscape of epilepsy-related GATOR1 variants (2018) (1)
A clinical study of 21 European families with dominant partial epilepsy (1999) (1)
Smooth pursuit in progressive supranuclear palsy (1995) (1)
[Epilepsy in the child and in the adult: Second part--adult epilepsy]. (2004) (0)
Nontoxic Stress Condition MAPK Regulates IL-4 Production in BMMC Selective Activation of Fyn / PI 3 K and p 38 (2007) (0)
Inactivation of catalytic and non-catalytic PI3 kinase gamma functions enhances hypoxia-induced pulmonary hypertension in mice (2022) (0)
University of Southern Denmark Mild malformations of cortical development in sleep-related hypermotor epilepsy due to KCNT1 mutations Rubboli, (2019) (0)
PHOSPHOINOSITIDE 3 KINASE BETA ATTENUATES INFLAMMATION AND FIBROSIS IN A BLEOMYCIN MODEL OF ACUTE LUNG INJURY (2009) (0)
Crystal Structure of human PI3Kgamma complexed with AS605240 (2005) (0)
Integrative Physiology Involvement of Phosphoinositide 3-Kinase in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice (2010) (0)
Generalized Convulsive Seizure Type, Oxygen Administration, Postictal Generalized EEG Suppression, and SUDEP Risk: Are They Related? (2016) (0)
IDENTIFICATION OF A FIRST AND MAJOR GENE FOR ACQUIRED EPILEPTIC APHASIA (LANDAU-KLEFFNER SYNDROME) AND RELATED CHILDHOOD FOCAL EPILEPSIES AND ENCEPHALOPATHIES WITH SPEECH AND LANGUAGE DYSFUNCTION (2013) (0)
Abnormal postures and movements during sleep (2003) (0)
of the Rho-GTPase via disruption of ArhGAP15 results in reduced architectural and functional complexity (0)
[Gougerot-Sjögren syndrome and polymyositis]. (1983) (0)
Inhibitors of Phosphatidylinositol 3-Kinases, compositions and uses thereof (2010) (0)
P318Phosphoinositide 3-kinase gamma inhibition as a novel strategy to reactivate targeted autophagy and limit Doxorubicin-induced cardiotoxicity (2018) (0)
[In this era of value for money what is the place of epilepsy surgery in hospital practice]. (2007) (0)
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation (2023) (0)
PI3K class II α: a novel regulator of vesicular trafficking at the base of the primary cilium (2012) (0)
functions The RacGAP ArhGAP15 is a master negative regulator of neutrophil (2012) (0)
Current treatment options for Familial Adult Myoclonus Epilepsy. (2023) (0)
INCREASED SUSCEPTIBILITY TO INTESTINAL INFLAMMATION OF MICE DEFICIENT IN TIR8, AN INHIBITORY MEMBER OF IL-1 RECEPTOR FAMILY EXPRESSED IN EPITHELIAL AND DENDRITIC CELLS (2004) (0)
P032 Chemical optimisation of a PI3Kγ competing peptide for the therapy of cystic fibrosis (2021) (0)
Guido Tarone (1951-2015). (2015) (0)
Treatment of Epilepsy : Focus on Levetiracetam (2005) (0)
Correction: The landscape of epilepsy-related GATOR1 variants (2018) (0)
The tyrosine kinase Pyk2 mediates the cross-talk between platelet integrins alpha 2 beta 1 and alpha IIb beta 3 (2011) (0)
Tissue-specific KO of ECM proteins. (2000) (0)
Erratum: The hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation (Chemistry and Biology (2014) 21 (1680-689)) (2015) (0)
Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2–2q11.2 (2016) (0)
Cell Invasion-PI 3 K-Induced Systemic Lupus but Not T A ( PI 3 K ) Deficiency Ameliorates I-Phosphatidylinositol 3-KinaseBClass (2005) (0)
Post-encephalitic extra-pyramidal syndrome associating akinesia and stereotyped movements responsive to L-dopa (1996) (0)
[Epileptogenic and non-epileptogenic zones: blood flow studies of temporo-limbic seizures]. (2007) (0)
The unexpected role of PI3-kinase gamma in pulmonary hypertension (2020) (0)
PI3KC2α: A novel key player in cardiac contractility and DOX-induced cardiotoxicity? (2022) (0)
Determination of positive and negative regulatory elements. (1999) (0)
Quantitation of Protein Phosphorylation Using Stable Isotope Dimethyl Labeling Coupled with Immobilized Metal Affinity Chromatography ( IMAC ) and Mass Spectrometry (2005) (0)
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress (2020) (0)
Analysis of Protein Phosphorylation in Halobacterium salinarum Analysis of Ser/Thr Phosphorylation by MALDI Mass Spectrometry A Novel Combined Genetic and Proteomic Approach to Identify PI3Kgamma-dependent Phosphorylated Proteins (2005) (0)
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis (2018) (0)
Doxorubicin-induced mitochondrial damage activates PI3Kgamma and inhibits protective cardiac autophagy (2018) (0)
PI3Kγ/AKT1 signaling in macrophages is essential for resistance against Trypanosoma cruzi infection (2015) (0)
Characterization of early cardiotoxicity action of calcineurin inhibitors (2018) (0)
Erratum: PTX3 plays a key role in the organization of the cumulus oophrus extracellular matrix and in in vivo fertilization (Development vol. 131 (1577-1586)) (2004) (0)
Putative role of tumor necrosis factor in the loss of dopaminergic neurons in Parkinson's disease (1992) (0)
Hyper-activation of the Rho-GTPase Rac1 via disruption of ArhGAP15 results in reduced architectural and functional complexity (2015) (0)
Effects of AAV9-mediated cardiac phosphodiesterase 4B and 2A overexpression in a mouse model of heart failure with preserved ejection fraction (2022) (0)
PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation (2015) (0)
Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells (2022) (0)
Crystal Structure of human PI3Kgamma complexed with AS604850 (2005) (0)
Polymer blends for vascular tissue engineering (2012) (0)
Melusin: A cardioprotective chaperone able to modulate lipid metabolism and ROS production in the heart (2020) (0)
Abstract 4988: PI3Kγ-deficiency protects against pancreatic tumorigenesis at the expense of diet-Induced hyperlipidemia and hepatotoxicity (2018) (0)
Rucaparib blocks SARS-CoV-2 virus binding to cells and interleukin-6 release in a model of COVID-19 (2022) (0)
Salvage pathways in heart rejuvenation. (2016) (0)
Phosphoinositide 3-kinase gamma at the crossroad between autophagy and metabolic control in doxorubicin-induced cardiomyopathy (2022) (0)
and p 85 / p 110 heterodimer immune synapse independently of its capacity to interact with the CD 28 provides T cell costimulation and enhances PI 3 K activity at the (2007) (0)
P4477Pi3kgamma inhibition rescues mice from acute cardiac contractile dysfunction, acquired long QT syndrome (acLQTS) and sudden death caused by calcineurin inhibitors (2017) (0)
Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
Role of pentraxin 3 in female fertility (2005) (0)
Response to the Letter by Seropian et al (2010) (0)
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 (2018) (0)
Species Generation-Dependent Neutrophil Reactive Oxygen Regulation of Adhesion-Independent and Kinases Play a Nonredundant Role in Class I Phosphoinositide-3-Kinases and Src (2013) (0)
Introduction of mutations into the murine integrin gene by homologous recombination (1990) (0)
5 PIK3c2G loss promotes pancreatic cancer through MTOR regulation and metabolic rewiring (2018) (0)
Role of PI3Kλ in β-adrenergic stimulation of cardiac contractility and L-type calcium current (2002) (0)
Melusin protects from cardiac rupture and improves functional remodelling in mice after myocardial infarction (2013) (0)
Revue de la littératureAntiepileptic drugs, H Levy, R Mattson, BS Meldrum, Fourth Edition, Raven Press, New York (1995), p. 1120 (1996) (0)
0377 : Phosphoinositide 3-kinase gamma: a potential clinical target in the prevention of vascular damages inuced by arterial injury (2015) (0)
Abstract IA22: Innate immune cell PI3K gamma as a target for suppression of pancreatic ductal adenocarcinoma (2015) (0)
Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage (2019) (0)
Chapter 2 Phosphoinositides and Cardiovascular Diseases (2012) (0)
Cardiac gene therapy of heart failure with phosphodiesterase PDE4B in mice (2019) (0)
Brief report Genetic evidence for a predominant role of PI3K (cid:1) catalytic activity in ITAM- and integrin-mediated signaling in platelets (2009) (0)
Activation of Rab11a and endocytosis by Phosphatidylinositol 4-kinase III beta promotes oncogenic signaling in breast cancer (2020) (0)
PI3KC2α, a new spindle associated protein involved in genomic instability and tumorigenesis (2016) (0)
Prokineticin-izing Doxorubicin-Damaged Hearts (2019) (0)
Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia (2015) (0)
Response to the numbering of seizure types (2017) (0)
Role and regulation of phosphatidylinositol 3-kinase (cid:1) in platelet integrin (cid:2) 2 (cid:1) 1 signaling (2012) (0)
Announcement: Heterocellular signalling and crosstalk in the heart in ischaemia and heart failureto be published in May, 2014 (2013) (0)
Stroke-like migraine attacks after radiation therapy : une complication tardive de la radiothérapie cérébrale (2014) (0)
Idiopathic epilepsy and cortical tremor of adult onset (2004) (0)
Chemical Oral Cancerogenesis Is Impaired in PI3Kγ Knockout and Kinase-Dead Mice (2021) (0)
Antiepileptic drugs, Fourth Edition, H Levy, R Mattson, BS Meldrum. Raven Press, New York (1995), 1120 (1996) (0)
Response by Vandecasteele et al to Letter Regarding Article, "Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure". (2021) (0)
Loss of PI3K-Gamma Scaffold Function causes Severe Electrical Remodeling in Mice Ventricular Myocytes (2015) (0)
A microfluidic device for cell migration measures in response to chemical stimuli (2008) (0)
Cdo Deficient Mice Display Cardiomyopathy with Alterations in Connexins (2015) (0)
Choking Fits During Sleep Related to Epilepsy. (2016) (0)
Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia (2017) (0)
Cardiac gene therapy with PDE2A limits ventricular remodeling, dysfunction and arrhythmias promoted in mice by chronic infusion with catecholamines (2022) (0)
haptoglobin/hemopexin double-null mice after acute hemolysis Enhanced splenomegaly and severe liver inflammation in (2013) (0)
Subthalamic nucleus and substantia nigra pars reticulata stimulation: the Grenoble experience (2020) (0)
O157 Mapping the function and connectivity of the cingulate gyrus using stereo-encephalography (SEEG) (2017) (0)
-morgana haploinsufficiency causes in mice a lethal and transplantable CML like myeloid neoplasm -morgana is underexpressed in aCML and in a subgroup of CMLs where predicts a worse response (0)
PO-466 PI3K-C2A regulates mitotic spindle assembly and chemotherapy response in breast cancer (2018) (0)
Non catalytic function of PI3Kg on smooth muscle cells proliferation: a novel therapeutic strategy to prevent arterial remodeling through cAMP modulation (2017) (0)
Integrins in development 725 Integrin function and regulation in development (2000) (0)
Editorial to the SI Leukocyte Adhesion and Migration. (2013) (0)
Vascular Remodeling in Cardiovascular Disease (2016) (0)
Chronic treatment with catecholamines favoured spontaneous calcium waves upon β-AR stimulation at the cellular level and promoted susceptibility to ventricular arrhythmias in vivo evoked by catheter-mediated (0)
Role of phosphoinositide 3-kinasese gamma in an ex-vivo model of ventilator induced lung injury. (2004) (0)
Comparison of 3 Tfr2- deﬁcient murine models suggests distinct functions for Tfr2- (cid:1) and Tfr2- (cid:2) isoforms in different tissues (2010) (0)
Phosphoinositide 3-Kinase γ Affects LPS-Induced Disturbance of Blood–Brain Barrier Via Lipid Kinase-Independent Control of cAMP in Microglial Cells (2014) (0)
Paroxysmal neurological manifestations: Panic attacks (1992) (0)
P6263Phosphoinositide 3-kinase gamma inhibition protects against anthracycline-induced cardiomyopathy by boosting cardiac autophagy (2017) (0)
PI3KC2α regulates cardiac contractility by restraining the β-adrenergic receptor/cyclic AMP (β-AR/cAMP) pathway (2022) (0)
Implication du gène SRPX2 dans des pathologies de l’aire rolandique (2007) (0)
The landscape of epilepsy-related GATOR1 variants (2018) (0)
Beneficial effects of a cardiac gene therapy with phosphodiesterase pde2a in a mouse model of heart failure (2022) (0)
Biallelic PDE2A Mutations: A New Cause of Intellectual Disability with Paroxysmal Dyskinesia and/or Epilepsy (2019) (0)
Correction to: The landscape of epilepsy-related GATOR1 variants (2018) (0)
[Ionic channels and epilepsy]. (2001) (0)
Abstract LT018: The perivascular niche protects ALK+ lymphoma cells from ALK inhibition through the CCL19/21-CCR7 axis (2021) (0)
29 – Paroxysmal Dyskinesia (2007) (0)
Epilepsy and neuroprotection: an illustrated review (Published with video sequences). (2002) (0)
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis (2018) (0)
Genetic disruption of the Rac inhibitor ArhGAP15 leads to aortic valve disease in mice (2015) (0)
PI3K γ AND PI3K δ : LINKERS OF COORDINATE C5aR-Fc γ R ACTIVATION AND IMMUNE COMPLEX-INDUCED INFLAMMATION * (2008) (0)
Abstract 348: Genetic Disruption of the PI3 Kinase {gamma} Impairs Reparative Neovascularization of Ischemic Limb Muscles and Depresses the Functionality of Bone Marrow-Derived Progenitor Cells (2006) (0)
Genetic analysis of beta1 integrin function (1997) (0)
P624Genetic disruption of the Rac inhibitor ArhGAP15 leads to aortic valve disease in mice (2014) (0)
OP13 – 2799: Landau-Kleffner syndrome (LKS), continuous spike and waves during slow-wave sleep syndrome (CSWSS), and Rolandic epilepsy (RE) – A genetic and immunological study (2015) (0)
Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics (2018) (0)
Non-Linear Reduction of Ion Currents in Cultured Cardiac Myocytes: Correlation with a Loss of T-Tubules? (2015) (0)
471 Pancreatic cancer therapy based on combination of DNA vaccination and PI3Kgamma inhibition (2020) (0)
[Paroxysmal neurological manifestations disclosing panic attacks]. (1992) (0)
[From historical EEG to signal treatment: applications in childhood epilepsy]. (2001) (0)
Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications (2023) (0)
Role of PI3K-gamma in ventilator induced lung injury (2004) (0)
Role of PI3K gamma in beta-adrenergic stimulation of cardiac contractility and L-type calcium current (2002) (0)
under Nontoxic Stress Condition MAPK Regulates IL-4 Production in BMMC Selective Activation of Fyn/PI3K and p38 (2013) (0)
[Epilepsy, medical and nursing news]. (2018) (0)
Expression of beta1 and alfa5 integrin genes (1990) (0)
P359Inhibition of phosphoinositide 3-kinase gamma protects against chemotherapy-induced heart failure (2014) (0)
Inhibition of phosphoinositide 3-kinase γ protects against chemotherapy-induced cardiomyopathy by promoting cardiac autophagy (2015) (0)
1093 The Absence of Functional PI3Kγ Has a Protective Effect On DSS-Induced Colitis in Mice (2009) (0)
Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy (2022) (0)
WS05.3 Characterisation of the molecular mechanisms underlying PI3Kγ-dependent stabilisation of CFTR at the plasma membrane (2020) (0)
Benign neonatal familial convulsions: a model for the study of idiopathic epilepsies (2008) (0)
Invasive EEG in Hypothalamic Hamartoma (2018) (0)
Mast cell degranulation requires activation of PI3K γ by PKC β (2009) (0)
Psoriasis-like Dermatitis Ameliorates Imiquimod-Induced Reduces IL-17 and γ or PI 3 K δ ( PI 3 K ) Blockade of Phosphatidylinositol 3-Kinase (2012) (0)
Doxorubicin promotes a cardiac metabolic switch from an oxidative metabolism to glycolysis through a PI3Kγ-dependent mechanism (2022) (0)
Non catalytic function of PI3KG on smooth muscle cells proliferation: A novel therapeutic strategy to prevent arterial remodeling through camp modulation. (2017) (0)
Long-term Outcome in Neurozika: When Biological Diagnosis Matters (S45.008) (2019) (0)
Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply (2016) (0)
300: Loss of PI3K-C2a promotes tumorigenesis and aneuploidy in breast cancer (2014) (0)
Des pionniers de l'EEG au traitement du signal : application à l'exploration des épilepsies de l'enfant (2002) (0)
Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth (2019) (0)
Genetic generalized epilepsy and generalized onset seizures with focal evolution (GOFE) (2022) (0)

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