Emilio Perucca
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Emilio Perucca's Degrees
- PhD Neuroscience University of Milan
- Masters Pharmacology University of Milan
- Bachelors Biology University of Milan
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(Suggest an Edit or Addition)Emilio Perucca's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- ILAE Official Report: A practical clinical definition of epilepsy (2014) (3352)
- Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies (2009) (2870)
- ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology (2017) (2773)
- Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies (2008) (894)
- ILAE Treatment Guidelines: Evidence‐based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes (2006) (751)
- International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods (2013) (726)
- Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry (2011) (647)
- Epilepsy: new advances (2015) (631)
- Pharmacological and Therapeutic Properties of Valproate (2002) (621)
- Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes (2013) (607)
- Clinically relevant drug interactions with antiepileptic drugs. (2006) (533)
- Antiepileptic Drugs as a Cause of Worsening Seizures (1998) (486)
- Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII) (2007) (439)
- Erratum: Definition of drug resistant epilepsy. Consensus proposal by the ad hoc task force of the ILAE commission on therapeutic strategies (Epilepsia (2010) 51 (1069-77)) (2010) (428)
- Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs (2003) (376)
- Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology (2009) (371)
- Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs (2003) (363)
- Idiosyncratic Adverse Reactions to Antiepileptic Drugs (2007) (326)
- Development of new antiepileptic drugs: challenges, incentives, and recent advances (2007) (320)
- Clinically Significant Pharmacokinetic Drug Interactions with Carbamazepine (1996) (318)
- Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy (2007) (307)
- Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII) (2004) (281)
- Seizure control and treatment in pregnancy (2006) (276)
- Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry (2018) (267)
- Apractical clinical definition of epilepsy (2014) (266)
- The pharmacological treatment of epilepsy in adults (2011) (263)
- Determinants of health‐related quality of life in pharmacoresistant epilepsy: Results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments (2011) (229)
- Seizure control and treatment changes in pregnancy: Observations from the EURAP epilepsy pregnancy registry (2013) (225)
- The Efficacy of Valproate‐Lamotrigine Comedication in Refractory Complex Partial Seizures: Evidence for a Pharmacodynamic Interaction (1999) (223)
- Identification of new epilepsy treatments: Issues in preclinical methodology (2012) (215)
- Rufinamide: Clinical pharmacokinetics and concentration–response relationships in patients with epilepsy (2008) (215)
- The Ketogenic diet: from molecular mechanisms to clinical effects (2006) (206)
- An International Multicenter Randomized Double‐Blind Controlled Trial of Lamotrigine and Sustained‐Release Carbamazepine in the Treatment of Newly Diagnosed Epilepsy in the Elderly (2007) (202)
- Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX) (2009) (200)
- Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. (2014) (200)
- Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI) (2013) (200)
- A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. (1984) (192)
- Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV) (1999) (190)
- Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI) (2002) (177)
- Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug (2016) (177)
- Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects (1990) (176)
- An Introduction to Antiepileptic Drugs (2005) (175)
- The new generation of antiepileptic drugs: advantages and disadvantages. (1996) (172)
- Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? (2017) (172)
- Birth defects after prenatal exposure to antiepileptic drugs (2005) (170)
- Relationship between adverse effects of antiepileptic drugs, number of coprescribed drugs, and drug load in a large cohort of consecutive patients with drug‐refractory epilepsy (2010) (168)
- Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X) (2010) (166)
- The Clinical Pharmacokinetics of the Newer Antiepileptic Drugs (1996) (165)
- Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII) (2015) (164)
- Plasma Protein Binding of Drugs in Pregnancy (1982) (162)
- Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics (2000) (161)
- A pharmacological and clinical review on topiramate, a new antiepileptic drug. (1997) (161)
- Induction of Ethinylestradiol and Levonorgestrel Metabolism by Oxcarbazepine in Healthy Women (1999) (156)
- Commission on Outcome Measurement in Epilepsy, 1994–1997: Final Report (1998) (153)
- Is There a Role for Therapeutic Drug Monitoring of New Anticonvulsants? (2000) (151)
- The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: The PuLsE (Open Prospective Randomized Long-term Effectiveness) trial (2014) (148)
- Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V) (2001) (146)
- Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial (2003) (143)
- Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta‐analysis (2011) (143)
- A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. (1986) (140)
- Effect of Fluvoxamine on the Pharmacokinetics of Imipramine and Desipramine in Healthy Subjects (1993) (134)
- Epilepsy, seizures, physical exercise, and sports: A report from the ILAE Task Force on Sports and Epilepsy (2016) (126)
- The Clinical Pharmacokinetics of the New Antiepileptic Drugs (1999) (126)
- Plasma concentrations of risperidone and 9-hydroxyrisperidone: effect of comedication with carbamazepine or valproate. (2000) (125)
- Clinical Significance of Pharmacokinetic Interactions Between Antiepileptic and Psychotropic Drugs (2002) (125)
- Relationship between plasma risperidone and 9-hydroxyrisperidone concentrations and clinical response in patients with schizophrenia (2000) (125)
- The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. (1980) (124)
- Vigabatrin in the Treatment of Epilepsy: A Double‐Blind, Placebo‐Controlled Study (1986) (122)
- Clinical Pharmacokinetics of New-Generation Antiepileptic Drugs at the Extremes of Age (2006) (121)
- Fetal Exposure to GABA‐Acting Antiepileptic Drugs Generates Hippocampal and Cortical Dysplasias (2007) (120)
- Perampanel, a selective, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial‐onset seizures: Interim results from phase III, extension study 307 (2013) (118)
- Assessing risk to benefit ratio in antiepileptic drug therapy (2000) (118)
- Keeping people with epilepsy safe during the COVID-19 pandemic (2020) (117)
- A Multicenter Randomized Controlled Trial on the Clinical Impact of Therapeutic Drug Monitoring in Patients with Newly Diagnosed Epilepsy (2000) (117)
- Dose-dependent teratogenicity of valproate in mono- and polytherapy (2015) (117)
- Clinical pharmacology and therapeutic use of the new antiepileptic drugs (2001) (115)
- Inhibition of Risperidone Metabolism by Fluoxetine in Patients With Schizophrenia: A Clinically Relevant Pharmacokinetic Drug Interaction (2002) (115)
- Interaction between phenytoin and valproic acid: Plasma protein binding and metabolic effects (1980) (112)
- Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development (2018) (111)
- Navigating toward Fetal and Maternal Health: The Challenge of Treating Epilepsy in Pregnancy (2004) (111)
- Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. (1992) (111)
- Disposition of sodium valproate in epileptic patients. (1978) (110)
- Add‐on Phenytoin Fails to Prevent Early Seizures after Surgery for Supratentorial Brain Tumors: A Randomized Controlled Study (2002) (110)
- Interaction of lamotrigine with sodium valproate (1993) (106)
- Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: Results from phase III extension study 307 (2014) (104)
- Antiepileptic drug therapy: Does mechanism of action matter? (2011) (102)
- Pharmacokinetics of valproic acid in the elderly. (1984) (100)
- Pharmacokinetics of valproic acid after oral and intravenous administration (1978) (100)
- Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials (2003) (100)
- Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII) (2017) (97)
- Inhibition of diazepam metabolism by fluvoxamine: A pharmacokinetic study in normal volunteers (1994) (96)
- Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine. (2005) (95)
- Enantioselective pharmacokinetics of 10‐hydroxycarbazepine after oral administration of oxcarbazepine to healthy Chinese subjects (1999) (90)
- Changes in the Disposition of Oxcarbazepine and Its Metabolites during Pregnancy and the Puerperium (2006) (87)
- Recommendations of the Italian League Against Epilepsy Working Group on Generic Products of Antiepileptic Drugs (2006) (86)
- The influence of dosage, age, and comedication on steady state plasma lamotrigine concentrations in epileptic children: a prospective study with preliminary assessment of correlations with clinical response. (1997) (85)
- Classification of the epilepsies: New concepts for discussion and debate—Special report of the ILAE Classification Task Force of the Commission for Classification and Terminology† (2016) (84)
- 30 years of second-generation antiseizure medications: impact and future perspectives (2020) (83)
- Epilepsy priorities in Europe: A report of the ILAE‐IBE Epilepsy Advocacy Europe Task Force (2015) (82)
- Epilepsy after head injury (2004) (82)
- Clinical Pharmacokinetics of New-Generation Antiepileptic Drugs at the Extremes of Age: An Update (2013) (82)
- Diurnal Fluctuations in Free and Total Steady‐State Plasma Levels of Carbamazepine and Correlation with Intermittent Side Effects (1984) (82)
- Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs. (1979) (81)
- EURAP: An International Registry of Antiepileptic Drugs and Pregnancy (2004) (80)
- Adverse effects of antiepileptic drugs (2005) (80)
- Harnessing the Clinical Potential of Antiepileptic Drug Therapy (2001) (79)
- Treatment of Status Epilepticus in Adults: Guidelines of the Italian League Against Epilepsy (2006) (78)
- Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy (2019) (78)
- Clinical Pharmacokinetics of Fluvoxamine (1994) (78)
- Small effects of valproic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. (1999) (77)
- ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (77)
- The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid. (1993) (76)
- Optimizing antiepileptic drug treatment in tumoral epilepsy (2013) (76)
- International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions (2022) (76)
- Pharmacological and clinical aspects of antiepileptic drug use in the elderly (2006) (75)
- Effect of fluoxetine on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenia. (1998) (75)
- Plasma concentrations of free and conjugated silybin after oral intake of a silybin-phosphatidylcholine complex (silipide) in healthy volunteers. (1994) (75)
- Reversible Pseudoatrophy of the Brain and Mental Deterioration Associated with Valproate Treatment (1998) (74)
- Identifying mutations in epilepsy genes: Impact on treatment selection (2019) (71)
- Novel Medications for Epilepsy (2011) (71)
- Pharmacological principles as a basis for polytherapy (1995) (70)
- Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. (2009) (70)
- Primidone in the long-term treatment of essential tremor: a prospective study with computerized quantitative analysis. (1990) (69)
- Monotherapy trials with the new antiepileptic drugs: study designs, practical relevance and ethical implications (1999) (69)
- Myoclonic status epilepticus following high-dosage lamotrigine therapy (1999) (69)
- Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: A pooled analysis of data from randomized clinical trials (2005) (69)
- Pharmacokinetic and Metabolic Investigation of Topiramate Disposition in Healthy Subjects in the Absence and in the Presence of Enzyme Induction by Carbamazepine (2005) (66)
- Vigabatrin and Epilepsy: Lessons Learned (2007) (66)
- Pharmacoresistance in Epilepsy (1998) (65)
- Water intoxication in epileptic patients receiving carbamazepine. (1978) (65)
- A multicenter, randomized, placebo‐controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy (2011) (64)
- Topiramate Pharmacokinetics in Children and Adults with Epilepsy (2005) (63)
- Visual Field Loss in Patients with Refractory Partial Epilepsy Treated with Vigabatrin (2009) (62)
- Final safety, tolerability, and seizure outcomes in patients with focal epilepsy treated with adjunctive perampanel for up to 4 years in an open‐label extension of phase III randomized trials: Study 307 (2018) (61)
- Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development (2018) (61)
- Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy. (1982) (61)
- Marketed New Antiepileptic Drugs: Are They Better Than Old-Generation Agents? (2002) (60)
- Free Fraction of Valproic Acid: In Vitro Time‐Dependent Increase and Correlation with Free Fatty Acid Concentration in Human Plasma and Serum (1983) (60)
- Metoprolol and propranolol in essential tremor: a double-blind, controlled study. (1981) (59)
- The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? (2003) (59)
- Evidence-based guideline: Antiepileptic drug selection for people with HIV/AIDS (2012) (59)
- Perampanel for adjunctive treatment of partial‐onset seizures: A pooled dose–response analysis of phase III studies (2014) (58)
- Antiepileptic drugs and intrauterine death (2015) (58)
- Plasma protein binding of phenytoin in health and disease: relevance to therapeutic drug monitoring. (1980) (57)
- Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP (2016) (57)
- Tiagabine in Clinical Practice (2001) (57)
- Clinical implications of hepatic microsomal enzyme induction by antiepileptic drugs. (1987) (56)
- Free Level Monitoring of Antiepileptic Drugs Clinical Usefulness and Case Studies (1984) (56)
- A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study. (1993) (55)
- Cardiac function and antiepileptic drug treatment in the elderly: A comparison between lamotrigine and sustained‐release carbamazepine (2009) (55)
- Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures (2011) (55)
- Patterns of prescription of antiepileptic drugs in patients with refractory epilepsy at tertiary referral centres in Italy (2010) (55)
- Double‐blind comparison of primidone and phenobarbital in essential tremor (1988) (55)
- Development of new treatment approaches for epilepsy: Unmet needs and opportunities (2013) (55)
- The response of essential tremor to propranolol: evaluation of clinical variables governing its efficacy on prolonged administration. (1983) (54)
- Serum Carbamazepine Concentrations in Elderly Patients: A Case‐matched Pharmacokinetic Evaluation Based on Therapeutic Drug Monitoring Data (2003) (54)
- Overtreatment in epilepsy: adverse consequences and mechanisms (2002) (54)
- Declining malformation rates with changed antiepileptic drug prescribing (2019) (54)
- Antiepileptic drug selection for people with HIV/AIDS: Evidence‐based guidelines from the ILAE and AAN (2012) (53)
- Genetic basis for idiosyncratic reactions to antiepileptic drugs (2009) (53)
- Pharmacokinetic Interactions with Antiepileptic Drugs (1982) (52)
- Antiepileptic drugs and brain maturation: Fetal exposure to lamotrigine generates cortical malformations in rats (2008) (52)
- A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy (2011) (52)
- Overtreatment in Epilepsy (2005) (52)
- Epileptogenesis and rational therapeutic strategies (2006) (51)
- The Management of Refractory Idiopathic Epilepsies (2001) (51)
- Progress report on new antiepileptic drugs A summary of the Second Eilat Conference (1995) (51)
- A Double‐Blind, Placebo‐Controlled Study on the Effect of Vigabatrin on In Vivo Parameters of Hepatic Microsomal Enzyme Induction and on the Kinetics of Steroid Oral Contraceptives in Healthy Female Volunteers (1997) (50)
- Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients. (1979) (50)
- Six‐year follow‐up study on the efficacy and safety of vigabatrin in patients with epilepsy (1992) (50)
- From global campaign to global commitment: The World Health Assembly's Resolution on epilepsy (2015) (50)
- Sodium Valproate and Valpromide: Differential Interactions with Carbamazepine in Epileptic Patients (1986) (50)
- Pharmacology of antiepileptic drugs during pregnancy and lactation (2007) (50)
- The current state of epilepsy guidelines: A systematic review (2016) (49)
- Drug metabolism in pregnancy, infancy and childhood. (1987) (49)
- The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate. (1996) (49)
- Effects of vigabatrin on evoked potentials in epileptic patients. (1989) (48)
- Epilepsy in elderly people: management issues. (2002) (48)
- The new antiepileptic drugs: pharmacological and clinical aspects. (2000) (48)
- Does carbamazepine have a narrow therapeutic plasma concentration range? (1998) (48)
- Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications (2020) (47)
- Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography. (2003) (46)
- ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions (2022) (46)
- A prospective study of direct medical costs in a large cohort of consecutively enrolled patients with refractory epilepsy in Italy (2015) (46)
- Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers (2009) (46)
- Increased Apparent Oral Clearance of Valproic Acid during Intake of Combined Contraceptive Steroids in Women with Epilepsy (2006) (46)
- Teratogenicity of antiepileptic drugs (2019) (45)
- Vigabatrin in the treatment of epilepsy: a long-term follow-up study. (1989) (45)
- Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study (2009) (45)
- Influence of Dosage, Age, and Co-medication on Plasma Topiramate Concentrations in Children and Adults with Severe Epilepsy and Preliminary Observations on Correlations with Clinical Response (2003) (45)
- A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy. (2000) (44)
- Epilepsy and comorbidity: infections and antimicrobials usage in relation to epilepsy management (2003) (43)
- CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects (2015) (43)
- Interaction between phenytoin and imipramine. (1977) (43)
- Extended-Release Formulations of Antiepileptic Drugs: Rationale and Comparative Value (2009) (43)
- Pharmacokinetics of silybin following oral administration of silipide in patients with extrahepatic biliary obstruction. (1994) (43)
- Effect of a single oral dose of propranolol on essential tremor: A double‐blind controlled study (1983) (43)
- Analysis of Topiramate and Its Metabolites in Plasma and Urine of Healthy Subjects and Patients With Epilepsy by Use of a Novel Liquid Chromatography–Mass Spectrometry Assay (2003) (42)
- Comparative effects of rifabutin and rifampicin on hepatic microsomal enzyme activity in normal subjects (2004) (41)
- Plasma Concentrations of the Enantiomers of Fluoxetine and Norfluoxetine: Sources of Variability and Preliminary Observations on Relations With Clinical Response (2002) (41)
- NICE guidance on newer drugs for epilepsy in adults (2004) (41)
- Effect of atenolol, metoprolol, and propranolol on isoproterenol‐induced tremor and tachycardia in normal subjects (1981) (41)
- Adverse drug interaction between risperidone and carbamazepine in a patient with chronic schizophrenia and deficient CYP2D6 activity. (2001) (40)
- Challenges in the clinical development of new antiepileptic drugs. (2016) (40)
- Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and in patients with epilepsy (1997) (40)
- Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy (2011) (40)
- Pharmacokinetic Profile of Topiramate in Comparison with Other New Antiepileptic Drugs (1996) (40)
- Perampanel effects in the WAG/Rij rat model of epileptogenesis, absence epilepsy, and comorbid depressive‐like behavior (2017) (39)
- Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects. (2003) (39)
- Controlled study of metoprolol and propranolol during prolonged administration in patients with essential tremor. (1982) (39)
- Tiagabine in the treatment of epilepsy — a clinical review with a guide for the prescribing physician (2000) (38)
- Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials (2020) (38)
- Pharmacokinetic Variability of New Antiepileptic Drugs at Different Ages (2005) (38)
- Drug interactions in epilepsy. (1980) (38)
- Simultaneous stereoselective high-performance liquid chromatographic determination of 10-hydroxycarbazepine and its metabolite carbamazepine-10,11-trans-dihydrodiol in human urine. (2000) (38)
- Revisiting phenobarbital for epilepsy (2004) (37)
- Is a separate monotherapy indication warranted for antiepileptic drugs? (2015) (37)
- Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference (1996) (37)
- Development and validation of an HPLC–UV detection assay for the determination of rufinamide in human plasma and saliva (2011) (37)
- Free Concentration of Carbamazepine and Carbamazepine-10,11-Epoxide in Children and Adults (1985) (36)
- Clinical consequences of microsomal enzyme-induction by antiepileptic drugs (1978) (36)
- Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis (2012) (35)
- The management of epilepsy in the 1990s. Acquisitions, uncertainties and priorities for future research. (1995) (35)
- Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy (2015) (35)
- Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy (2010) (35)
- Daytime sleepiness in epileptic patients on long-term monotherapy: MSLT, clinical and psychometric assessment (1993) (34)
- Pregabalin for the management of partial epilepsy (2008) (34)
- International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions (2022) (34)
- Effect of Adjunctive Lamotrigine Treatment on the Plasma Concentrations of Clozapine, Risperidone and Olanzapine in Patients With Schizophrenia or Bipolar Disorder (2006) (34)
- Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). II. Drugs in more advanced clinical development (2020) (34)
- Serum Protein Binding of Phenytoin and Valproic Acid in Insulin‐Dependent Diabetes Mellitus (1987) (33)
- Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical and early clinical development (2020) (33)
- Effect of valproate on free plasma phenytoin concentrations. (1984) (33)
- Mechanism of altered drug binding to serum proteins in pregnant women: studies with valproic acid. (1984) (33)
- Influence of aging on serum phenytoin concentrations: a pharmacokinetic analysis based on therapeutic drug monitoring data (2004) (33)
- Designing Clinical Trials to Assess Antiepileptic Drugs as Monotherapy (2008) (33)
- Omeprazole Does Not Enhance the Metabolism of Phenacetin, a Marker of CYP1A2 Activity, in Healthy Volunteers (1994) (32)
- Interaction of Carbamazepine‐10,11‐Epoxide, an Active Metabolite of Carbamazepine, with Valproate: A Pharmacokinetic Study (1990) (32)
- Cost Minimization Analysis of Antiepileptic Drugs in Newly Diagnosed Epilepsy in 12 European Countries (2000) (32)
- Vigabatrin-induced decrease in serum phenytoin concentration does not involve a change in phenytoin bioavailability. (1993) (31)
- Antiepileptic drugs: evolution of our knowledge and changes in drug trials. (2019) (31)
- Current Trends in Antiepileptic Drug Therapy (2003) (31)
- Reversal by phenytoin of carbamazepine-induced water intoxication: a pharmacokinetic interaction. (1980) (31)
- Epilepsy care during the COVID‐19 pandemic (2021) (31)
- Pharmacologic Advantages of Antiepileptic Drug Monotherapy (1997) (31)
- The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data (2006) (30)
- Treatment of epilepsy in developing countries (2007) (30)
- Plasma Gabapentin Concentrations in Children With Epilepsy: Influence of Age, Relationship With Dosage, and Preliminary Observations on Correlation With Clinical Response (2003) (30)
- Single-Dose Pharmacokinetics of Lamotrigine in Children: Influence of Age and Antiepileptic Comedication (2001) (30)
- What clinical trial designs have been used to test antiepileptic drugs and do we need to change them? (2012) (30)
- Quantitative comparison of barbiturates in essential hand and head tremor (1991) (30)
- From clinical trials of antiepileptic drugs to treatment (2018) (29)
- Cannabidiol in the treatment of epilepsy: Current evidence and perspectives for further research (2020) (29)
- Low risk pragmatic trials do not always require participants’ informed consent (2019) (29)
- Methodology for classification and definition of epilepsy syndromes with list of syndromes: Report of the ILAE Task Force on Nosology and Definitions (2022) (29)
- Carbamazepine-viloxazine interaction in patients with epilepsy. (1986) (29)
- What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS‐1209, and topiramate (2009) (29)
- Interpretation of Drug Levels in Acute and Chronic Disease States (1985) (29)
- Quality Control in Drug Measurement (1980) (29)
- DECREASED SERUM PROTEIN BINDING OF PHENYTOIN IN LATE PREGNANCY (1980) (28)
- Phenobarbital induces the 2-hydroxylation of desipramine. (1996) (28)
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- Genetic testing to prevent adverse reactions to antiepileptic drugs (2017) (1)
- A Tribute to Steve White (2017) (1)
- Comprar The Treatment of Epilepsy 3ed | Jerome Engel, Jr. | 9781405183833 | Wiley (2009) (1)
- Pharmacokinetic and pharmacodynamic studies following single and multiple doses of rolafagrel, a novel inhibitor of thromboxane synthase, in normal volunteers (2007) (1)
- EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper (2022) (1)
- Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy (2020) (1)
- Preface (2001) (1)
- Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy (2022) (1)
- Effects of some autonomic drugs on the electrical activity of intestinal circular muscle. (1976) (1)
- Hormone Replacement Therapy in Women with Epilepsy (2007) (1)
- Lack of Effect of Cholestyramine on Phenytoin Bioavailability (1988) (1)
- Pharmacokinetics of FCE 22178 during a multiple-dose regimen in healthy volunteers and relationship with throm☐ane B2 production (1990) (1)
- Efficacy and tolerability with long-term administration of vigabatrin. (1988) (1)
- Vigabatrin in the treatment of epilepsy: A long-term efficacy and safety evaluation (1988) (1)
- Evaluations and Awards at the Fifth European Congress of Epileptology, Madrid, 6–10 October 2002 (2004) (1)
- Introduction (2005) (0)
- In Memoriam: Hanneke De Boer (1946-2015). (2016) (0)
- Trials in women (2001) (0)
- The disposition of theophylline in patients with lung and breast cancer. (1994) (0)
- Editorial Board (2011) (0)
- Lacosamide (2019) (0)
- Issue Information–ISSN page (2017) (0)
- Improving epilepsy for life: Editorial comment (2002) (0)
- Implementation of VNS (vagal nerve stimulation) Pulse (prospective long-term effectiveness) study in Italy (2007) (0)
- Issue Information (2017) (0)
- EffectofAdjunctiveLamotrigineTreatmentonthePlasma ConcentrationsofClozapine,RisperidoneandOlanzapine in Patients With Schizophrenia or Bipolar Disorder (2006) (0)
- Peristaltic reflex: supersensitivity to catecholamines. I. The muscular site of action. (1976) (0)
- Neuropsychiatric therapies. (1999) (0)
- The 50th anniversary of the Italian League against epilepsy (Lega Italiana Contro l’Epilessia) (2022) (0)
- Proposal for reference values for the developmental effects of valproate based on human data using a benchmark dose approach. (2023) (0)
- Faculty Opinions recommendation of Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304. (2012) (0)
- Editorial Board (2011) (0)
- Editorial Board (2006) (0)
- Editorial Board (2011) (0)
- [Gestation of 42 weeks or longer. Management protocol]. (1989) (0)
- Disposition of primidone in the elderly (1990) (0)
- [Spontaneous liver rupture in pregnancy-induced hypertension]. (1991) (0)
- In vivo plasma protein binding interaction between valproic acid and naproxen (1984) (0)
- Editorial Board (2007) (0)
- Interaction between viloxazine and phenytoin (1990) (0)
- Lead inhibits cholinergic transmission in the guinea-pig myenteric plexus-longitudinal muscle preparation (1985) (0)
- The ultrafree drug filters: need for closer evaluation. (1981) (0)
- Reflections on monotherapy trials for epilepsy – Authors' reply (2016) (0)
- Editorial Board (2011) (0)
- Peristaltic reflex: supersensitivity to catecholamines. II. The inhibition of the nervous structures. (1976) (0)
- Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy (2022) (0)
- Alterations of drug toxicity in neuropsychiatric disease states. (1984) (0)
- A RANDOMISED OPEN-LABEL COMPARISON OF THE EF- FICACY, TOLERABILITY, AND HORMONAL EFFECTS OF SODIUM VALPROATE AND LAMOTRIGINE MONOTHERAPY IN NEWLY-DIAGNOSED EPILEPSY (2006) (0)
- Long-term efficacy and safety of Vigabatrin in drug resistant epileptic patients (1988) (0)
- [Pustular psoriasis in pregnancy]. (1995) (0)
- The Impact of Enzyme-Inducing Antiepileptic Drugs on Antiretroviral Drugs: A Case-Control Study (2013) (0)
- Comparative pharmacokinetics and pharmacodynamics of eterobarbital and phenobarbital in normal volunteers (2010) (0)
- Editorial Board (2006) (0)
- Editorial Board (2007) (0)
- Editorial Board & Aims and Scopes (2006) (0)
- Does mechanism of action matter when selecting an antiepileptic drug? (2015) (0)
- Pharmacokinetic Optimization of Therapy (2015) (0)
- A multicentre, randomized prospective trial comparing add-on therapy with alternative monotherapy in patients with partial seizures refractory to initial treatment (1997) (0)
- Effects of pentazocine on gastro-intestinal smooth muscle.--II. Ileum and Oddi's sphincter. (1976) (0)
- [Toxicological study of the combination trimethoprim-sulfamethoxypyrazine]. (1977) (0)
- New antiepileptic drugs and clinical trial designs (2000) (0)
- [Obstetrical and perinatal aspects in renal transplantation]. (1994) (0)
- Too Complicated or So Simple: AED Type and AED Dose Matter for Pregnancy (2012) (0)
- F1000Prime recommendation of Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. (2012) (0)
- Editorial Board (2008) (0)
- Editorial Board (2010) (0)
- Current State Of International Epilepsy Guidelines (2015) (0)
- [Obstetric and perinatal management of myasthenia gravis]. (1989) (0)
- Author Response: Does Screening for Adverse Effects Improve Health Outcomes in Epilepsy? A Randomized Trial (2020) (0)
- [Interactions among epileptic drugs. Retrospective study of the serum levels of a large patient population]. (1986) (0)
- Editorial Board (2011) (0)
- Should antiseizure medications be withdrawn after an extended period of seizure freedom in individuals with adult-onset epilepsy? (2023) (0)
- A Tribute to Steve White (2016) (0)
- Acta Neurologica Scandinavica: Introduction (2005) (0)
- Alpha-lactoalbumin, a whey protein rich in tryptophan, is effective in rodent models of seizures and epileptogenesis (2012) (0)
- Low-risk pragmatic trials with medicines and the need for participant’s informed consent (2018) (0)
- Editorial Board (2011) (0)
- [Massive digestive hemorrhage secondary to typhoid ulcer in pregnancy]. (1993) (0)
- [Epidemiological observations on plasma levels of diphenylhydantoin in 130 patients on prolonged treatment (author's tranls)]. (1976) (0)
- MECHANISM OF ACTION OF BETA-ADERNOCEPTOR BLOCKING DRUGS IN ESSENTIAL TREMOR (1984) (0)
- EURAP registry: inadequate monitoring of prescribed drugs in pregnancy – Authors' reply (2018) (0)
- New antiepiletic drugs (1993) (0)
- [Bladder cancer, primary and during pregnancy]. (1986) (0)
- Editorial Board (2006) (0)
- Editorial Board (2011) (0)
- Editorial Board (2008) (0)
- [Leukemia and pregnancy. Review apropos of a clinical case]. (1995) (0)
- Response: Cannabidiol antiseizure activity and its interactions with clobazam: “It’s déjà vu all over again” Yogi Berra (2020) (0)
- In memoriam: Harry Meinardi (February 20, 1932-December 20, 2013). (2014) (0)
- XEN1101, a Novel Potassium Channel Modulator: Interim Data From an Ongoing, Long-Term, Open-Label Extension of a Phase 2b study (X-TOLE) in Adults with Focal Epilepsy (S44.008) (2023) (0)
- Letters to the Editor (1997) (0)
- Correction: Perampanel as first add-on antiseizure medication: Italian consensus clinical practice statements (2022) (0)
- Assessing relative risks of fetal malformations following prenatal exposure to old and new antiepileptic drugs: The international EURAP pregnancy registry initiative (2002) (0)
- Use of cenobamate for the treatment of focal epilepsy: an Italian expert opinion paper (2022) (0)
- Editorial Board (2011) (0)
- New classification of epilepsy and its syndromes (2017) (0)
- Editorial Board (2007) (0)
- Site of action of catecholamines on the peristaltic reflex. (1976) (0)
- Editorial Board (2007) (0)
- Editorial Board (2007) (0)
- Antiepileptic drugs (2016) (0)
- Editorial Board (2008) (0)
- Cytochrome P450IID6-related oxidation polymorphism in Italy (1992) (0)
- Editorial Board (2010) (0)
- Effect of antacids on famotidine bioavailability (1988) (0)
- Usefulness and limitations of monitoring serum levels of antiepileptic drugs (1990) (0)
- Ketoprofen penetration into suction skin blister fluid: A comparison of two topical formulations of ketoprofen lysine (1993) (0)
- A young woman with recurring seizures. (2011) (0)
- Editorial Board (2008) (0)
- Editorial Board (2008) (0)
- Pregabalin as adjunctive treatment of partial seizures: A viewpoint (2005) (0)
- Commentary: Message from the ILAE president (2016) (0)
- Comparative Activity of the Enantiomers of Fenfluramine and Norfenfluramine in Rodent Seizure Models, and Relationship with their Concentrations in Plasma and Brain. (2023) (0)
- REPLY (2000) (0)
- Epilepsy management during difficult times (2022) (0)
- Use and misuse of new antiepileptic drugs (2019) (0)
- Epileptic Disorders to become the educational journal of the ILAE (2013) (0)
- [Effect of antacids on the bioavailability of carbenoxolone]. (1987) (0)
- Patient with circulating antibodies to alpha-interferon. (1981) (0)
- [Eclampsia: 8-year experience]. (1994) (0)
- Penicillin CSF levels following intravenous therapy in syphilitic patients (1983) (0)
- Preface (2006) (0)
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What Schools Are Affiliated With Emilio Perucca?
Emilio Perucca is affiliated with the following schools:
