Emmanuel Van Obberghen
#152,442
Most Influential Person Now
Emmanuel Van Obberghen's AcademicInfluence.com Rankings
Emmanuel Van Obberghenbiology Degrees
Biology
#11492
World Rank
#14892
Historical Rank
Cell Biology
#582
World Rank
#595
Historical Rank
Molecular Biology
#1771
World Rank
#1800
Historical Rank
Neuroscience
#1865
World Rank
#1921
Historical Rank
Download Badge
Biology
Emmanuel Van Obberghen's Degrees
- PhD Molecular and Cellular Biology University of California, Berkeley
Why Is Emmanuel Van Obberghen Influential?
(Suggest an Edit or Addition)Emmanuel Van Obberghen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway* (2002) (543)
- SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice* (2001) (480)
- SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling* (2000) (476)
- Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation* (2003) (433)
- miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells (2008) (393)
- MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines* (2007) (342)
- Malnutrition is an independent factor associated with nosocomial infections. (2004) (330)
- Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells. (1994) (329)
- Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. (1994) (298)
- Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase (1999) (269)
- Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking. (1981) (265)
- Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action (*) (1996) (249)
- Glucose, Other Secretagogues, and Nerve Growth Factor Stimulate Mitogen-activated Protein Kinase in the Insulin-secreting β-Cell Line, INS-1 (*) (1995) (232)
- Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. (1993) (224)
- Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species (2006) (205)
- Insulin and Insulin-like Growth Factor-I Induce Vascular Endothelial Growth Factor mRNA Expression via Different Signaling Pathways* (2000) (205)
- Regulation of Vascular Endothelial Growth Factor Expression by Advanced Glycation End Products* (2001) (202)
- MicroRNAs and metabolism crosstalk in energy homeostasis. (2013) (196)
- cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner (1997) (189)
- Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591786 (*) (1996) (163)
- Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes* (1996) (163)
- Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. (1981) (161)
- A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis (1987) (160)
- Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist. (1993) (157)
- Two types of receptor for insulin‐like growth factors in mammalian brain. (1985) (153)
- Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. (1997) (148)
- Insulin receptors, receptor antibodies, and the mechanism of insulin action. (1981) (148)
- The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. (1993) (143)
- Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation (2000) (141)
- Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form. (1983) (139)
- Grb10 Prevents Nedd4-mediated Vascular Endothelial Growth Factor Receptor-2 Degradation* (2004) (139)
- Insulin‐like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase. (1987) (138)
- Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. (1983) (137)
- SOCS proteins causing trouble in insulin action (2007) (135)
- Human Glycated Albumin Affects Glucose Metabolism in L6 Skeletal Muscle Cells by Impairing Insulin-induced Insulin Receptor Substrate (IRS) Signaling through a Protein Kinase Cα-mediated Mechanism* (2003) (134)
- Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. (1981) (133)
- Insulin and okadaic acid induce Rab4 redistribution in adipocytes. (1993) (132)
- Molecular mechanisms of insulin receptor substrate protein‐mediated modulation of insulin signalling (2003) (130)
- Expression of IGF‐I and insulin receptor genes in the rat central nervous system: A developmental, regional, and cellular analysis (1991) (129)
- 125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. (1978) (128)
- Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. (1981) (122)
- Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I. (2005) (120)
- Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System (*) (1995) (119)
- p125Fak Focal Adhesion Kinase Is a Substrate for the Insulin and Insulin-like Growth Factor-I Tyrosine Kinase Receptors* (1998) (119)
- Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice. (1993) (118)
- Phosphoinositide 3-Kinase-mediated Reduction of Insulin Receptor Substrate-1/2 Protein Expression via Different Mechanisms Contributes to the Insulin-induced Desensitization of Its Signaling Pathways in L6 Muscle Cells* (2003) (116)
- Protein kinase activity of the insulin receptor. (1986) (115)
- Expression of two types of receptor for insulin-like growth factors in human malignant glioma. (1988) (114)
- Surfing the insulin signaling web (2001) (112)
- Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes. (1997) (111)
- Calcium Antagonists and Islet Function: I. Inhibition of Insulin Release by Verapamil (1975) (110)
- FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes (2008) (109)
- Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor. (1994) (108)
- Interaction of Janus Kinases JAK-1 and JAK-2 with the Insulin Receptor and the Insulin-Like Growth Factor-1 Receptor. (1998) (106)
- In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs* (2008) (106)
- Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes (1996) (105)
- Internalized insulin receptors are recycled to the cell surface in rat hepatocytes. (1982) (99)
- Function of microRNA‐375 and microRNA‐124a in pancreas and brain (2009) (98)
- Glucocorticoid-induced insulin resistance in vitro: evidence for both receptor and postreceptor defects. (1981) (98)
- Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites. (1988) (96)
- Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. (1994) (94)
- The Matricellular Protein SPARC/Osteonectin as a Newly Identified Factor Up-regulated in Obesity* (2001) (94)
- Dynamics of insulin release and microtubular-microfilamentous system. I. Effect of cytochalasin B. (1973) (94)
- AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. (2010) (94)
- Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. (1989) (92)
- Regulation of the MAP kinase cascade in PC12 cells: B‐Raf activates MEK‐1 (MAP kinase or ERK kinase) and is inhibited by cAMP (1995) (89)
- Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. (1996) (87)
- Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles. (1982) (85)
- Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells. (1995) (83)
- Focal Adhesion Kinase pp125FAK Interacts With the Large Conductance Calcium‐Activated hSlo Potassium Channel in Human Osteoblasts: Potential Role in Mechanotransduction (2003) (83)
- Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα) (2001) (82)
- Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice (2004) (81)
- Modulation of glucose metabolism by the renin-angiotensin-aldosterone system. (2015) (81)
- Molecular association between major histocompatibility complex class I antigens and insulin receptors in mouse liver membranes. (1985) (80)
- Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: A multicenter case–control study (2008) (80)
- Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. (2003) (76)
- Adipocytes Secrete Leukotrienes (2012) (69)
- Glucose transporter in insulin sensitive tissues of lean and obese mice. Effect of the thermogenic agent BRL 26830A. (1990) (69)
- Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. (1996) (69)
- Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity (1999) (68)
- Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375 (2014) (68)
- Transphosphorylation as a possible mechanism for insulin and epidermal growth factor receptor activation. (1990) (66)
- Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase* (2001) (65)
- Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor* (1997) (65)
- Surface redistribution of 125I-insulin in cultured human lymphocytes (1981) (64)
- Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules. (1998) (63)
- Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes: a quantitative morphological and biochemical study (1980) (62)
- Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system. (1996) (61)
- Regulation of the Pancreatic Duodenal Homeobox-1 Protein by DNA-dependent Protein Kinase* (2005) (61)
- Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B* (1998) (60)
- Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activity. (1993) (60)
- Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration. (1981) (59)
- Two different protein kinase activities are associated with the insulin receptor. (1983) (58)
- Thermodynamics of the interaction of insulin with its receptor. (1979) (57)
- Fatty Aldehyde Dehydrogenase (2004) (55)
- Desensitization of the insulin receptor at an early postreceptor step by prolonged exposure to antireceptor antibody. (1979) (55)
- The Insulin Receptor and Insulin of the Atlantic Hagfish: Extraordinary Conservation of Binding Specificity and Negative Cooperativity in the Most Primitive Vertebrate (1979) (55)
- Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts. (1982) (54)
- Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. (1976) (54)
- Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: phosphorylation and activation by cAMP-dependent protein kinase. (2000) (53)
- In Rat Hepatocytes Glucagon Increases Mammalian Target of Rapamycin Phosphorylation on Serine 2448 but Antagonizes the Phosphorylation of Its Downstream Targets Induced by Insulin and Amino Acids* (2004) (53)
- Insulin and insulin-like-growth-factor-I (IGF-I) receptors in Xenopus laevis oocytes. Comparison with insulin receptors from liver and muscle. (1991) (53)
- The insulin receptor activation process involves localized conformational changes. (1992) (52)
- Effects of okadaic acid, an inhibitor of protein phosphatases-1 and -2A, on glucose transport and metabolism in skeletal muscle. (1991) (51)
- Identification of Stat 5B as a substrate of the insulin receptor. (1997) (51)
- [Mechanisms of insulin resistance]. (1989) (49)
- Intermolecular transphosphorylation between insulin receptors and EGF‐insulin receptor chimerae. (1989) (49)
- The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells. (2004) (49)
- Signal transduction by a chimeric insulin-like growth factor-1 (IGF-1) receptor having the carboxyl-terminal domain of the insulin receptor. (1994) (48)
- Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system. (1996) (47)
- Differential Role of Insulin Receptor Substrate (IRS)-1 and IRS-2 in L6 Skeletal Muscle Cells Expressing the Arg1152 → Gln Insulin Receptor* (1999) (47)
- Nerve growth factor-induced phosphorylation cascade in PC12 pheochromocytoma cells. Association of S6 kinase II with the microtubule-associated protein kinase, ERK1. (1992) (47)
- Insulin receptors in the mammalian central nervous system: binding characteristics and subunit structure. (1985) (46)
- Incidence and Characteristics of Acute Kidney Injury in Severe Diabetic Ketoacidosis (2014) (45)
- Insulin-stimulated glucose transport in muscle. Evidence for a protein-kinase-C-dependent component which is unaltered in insulin-resistant mice. (1989) (45)
- Cross-talk between the Platelet-derived Growth Factor and the Insulin Signaling Pathways in 3T3-L1 Adipocytes* (1997) (45)
- Role of diabetes in atherosclerotic pathogenesis. What have we learned from animal models? (2006) (45)
- Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice. (1995) (44)
- Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase. (1985) (44)
- Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities. (1993) (43)
- Insulin-induced receptor loss in the cultured human lymphocyte: quantitative morphological perturbations in the cell and plasma membrane. (1979) (42)
- Calcium antagonists and islet function. II. Interaction of theophylline and verapamil. (1976) (41)
- Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. (2007) (41)
- miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes. (2009) (40)
- Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling. (2001) (40)
- Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. (1994) (40)
- Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue. (2006) (40)
- Insulin binding to its receptor induces a conformational change in the receptor C-terminus. (1990) (40)
- Identification of G Protein α-Subunits in RINm5F Cells and Their Selective Interaction with Galanin Receptor (1991) (39)
- Subcellular distribution of low molecular weight guanosine triphosphate-binding proteins in adipocytes: colocalization with the glucose transporter Glut 4. (1991) (39)
- Insulin Receptor Substrate-2 Phosphorylation Is Necessary for Protein Kinase Cζ Activation by Insulin in L6hIR Cells* (2001) (39)
- Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity. (1987) (38)
- Involvement of Janus kinases in the insulin signaling pathway. (1995) (38)
- Insulin stimulates phosphatidylinositol-3-kinase activity in rat adipocytes. (1992) (37)
- Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents (2018) (37)
- Evaluation of the Sensitivity of Inhomogeneous Magnetization Transfer (ihMT) MRI for Multiple Sclerosis (2018) (36)
- Signalling through the insulin receptor and the insulin-like growth factor-I receptor. (1994) (35)
- Antibody-induced desensitization of the insulin receptor. Studies of the mechanism of desensitization in 3T3-L1 fatty fibroblasts. (1980) (35)
- Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F). (1985) (35)
- Dynamics of Insulin Release and Microtubular-microfilamentous System: VII. Do Microfilaments Provide the Motive Force for the Translocation and Extrusion of Beta Granules? (1974) (34)
- Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. (2008) (34)
- Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation. (1996) (33)
- Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α (2002) (32)
- Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. (1998) (31)
- Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats. (1993) (31)
- Dephosphorylation of the hepatic insulin receptor: absence of intrinsic phosphatase activity in purified receptors. (1983) (30)
- Vav2 Activates c-fos Serum Response Element and CD69 Expression but Negatively Regulates Nuclear Factor of Activated T Cells and Interleukin-2 Gene Activation in T Lymphocyte* (2001) (30)
- Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1. (1994) (30)
- Fast urinary screening of oligosaccharidoses by MALDI-TOF/TOF mass spectrometry (2014) (29)
- AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1. (2006) (29)
- Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats. (1987) (28)
- Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-kinase. (1995) (28)
- The interaction of 125I-insulin with cultured 3T3-L1 adipocytes: quantitative analysis by the hypothetical grain method. (1983) (28)
- Antibodies to phosphotyrosine injected in Xenopus laevis oocytes modulate maturation induced by insulin/IGF-I. (1991) (28)
- Effects of age, malnutrition and refeeding on the expression and secretion of ghrelin. (2008) (28)
- Stat 5B, Activated by Insulin in a Jak-Independent Fashion, Plays a Role in Glucokinase Gene Transcription. (2000) (26)
- Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling (1986) (26)
- 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes. (2008) (25)
- Receptors for insulin-like growth factors in the central nervous system: structure and function. (1988) (24)
- Involvement of protein kinase B and mitogen‐activated protein kinases in experimental normothermic liver ischaemia–reperfusion injury (2006) (24)
- Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells. (1995) (24)
- Insulin receptor internalization and recycling: mechanism and significance. (1985) (24)
- Bombesin stimulates cholecystokinin secretion through mitogen-activated protein-kinase-dependent and -independent mechanisms in the enteroendocrine STC-1 cell line. (1998) (23)
- The molecular basis of succinic semialdehyde dehydrogenase deficiency in one family. (2004) (23)
- The carboxyl-terminal domain of the insulin receptor: its potential role in growth-promoting effects. (1991) (23)
- Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor. (1993) (22)
- Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382. (1993) (22)
- Tyrosine and threonine phosphorylation of an immunoaffinity-purified 44-kDa MAP kinase. (1991) (21)
- Nonsuppressed Glucagon After Glucose Challenge as a Potential Predictor for Glucose Tolerance (2016) (21)
- Fas ligand expression following normothermic liver ischemia-reperfusion. (2005) (21)
- Interaction between heterologous receptor tyrosine kinases (1991) (20)
- Age-Dependent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet–Induced Fetal Programming (2016) (19)
- The Effect of Cyclic Adenosine Monophosphate on the Mitogen-Activated Protein Kinase Pathway Depends on Both the Cell Type and the Type of Tyrosine Kinase-Receptor. (1997) (19)
- Characterization of 6-deoxy-6-iodo-D-glucose: a potential new tool to assess glucose transport. (1997) (19)
- Potential involvement of FRS2 in insulin signaling. (2000) (19)
- Human γ enolase: Isolation of a cDNA clone and expression in normal and tumor tissues of human origin (1988) (19)
- RNA Activation of the Vascular Endothelial Growth Factor Gene (VEGF) Promoter by Double-Stranded RNA and Hypoxia: Role of Noncoding VEGF Promoter Transcripts (2016) (18)
- Insulin stimulates tyrosine phosphorylation of its receptor beta-subunit in intact rat hepatocytes. (1987) (18)
- Presence of an insulin-stimulated serine kinase in cell extracts from IM-9 cells. (1986) (17)
- Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. (1997) (17)
- Binding, membrane redistribution, internalization and lysosomal association of [125I]anti-insulin receptor antibody in IM-9-cultured human lymphocyte. A comparison with [125I]insulin. (1981) (17)
- Effect of a thermogenic agent, BRL 26830A, on insulin receptors in obese mice. (1988) (17)
- Phenylarsine oxide stimulates a cytosolic tyrosine kinase activity and glucose transport in mouse fibroblasts. (1991) (16)
- Stat 5B, activated by insulin in a Jak-independent fashion, plays a role in glucokinase gene transcription. (2000) (16)
- Expression of the glucose transporter GLUT4 in the muscular dystrophic mdx mouse. (1993) (16)
- The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. (1993) (16)
- Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect. (2007) (15)
- Oligomeric states of the insulin receptor: binding and autophosphorylation properties. (1989) (15)
- The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor. (1997) (15)
- Spontaneous hypoglycaemia in the presence of both anti-insulin antibody and anti-insulin receptor antibody. (2006) (15)
- Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors. (1991) (15)
- Dephosphorylation of human insulin-like growth factor I (IGF-I) receptors by membrane-associated tyrosine phosphatases. (1992) (15)
- Receptor-mediated endocytosis of polypeptide hormones is a regulated process: inhibition of [125I]iodoinsulin internalization in hypoinsulinemic diabetes of rat and man. (1986) (14)
- Dynamin associates with Src-Homology Collagen (Shc) and becomes tyrosine phosphorylated in response to insulin. (1998) (14)
- Hrs is a positive regulator of VEGF and insulin signaling. (2007) (14)
- The endosomal compartment of rat hepatocytes. Its characterization in the course of [125I]insulin internalization. (1985) (14)
- Inhibition of insulin receptor binding by dimethyl sulfoxide. (1979) (12)
- Antiepileptic drugs: a case report in a pregnancy with a neural tube defect. (2006) (11)
- Polymyxin B selectively inhibits insulin effects on transport in isolated muscle. (1987) (11)
- Dynamin Associates with Src-Homology Collagen (SHC) and Becomes Tyrosine Phosphorylated in Response to Insulin. (1998) (11)
- Shaping and preserving β‐cell identity with microRNAs (2016) (10)
- Familial pernicious anaemia with hyperhomocysteinaemia in recurrent early pregnancy loss (2004) (10)
- Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes. (1992) (10)
- Insulin receptor: tyrosine kinase activity and insulin action. (1989) (10)
- Okadaic acid stimulates IGF-II receptor translocation and inhibits insulin action in adipocytes. (1993) (10)
- Antibodies to insulin receptor tyrosine kinase stimulate its activity towards exogenous substrates without inducing receptor autophosphorylation. (1989) (9)
- Internalization and recycling of insulin receptors in hepatoma cells. Absence of regulation by receptor occupancy. (1984) (9)
- Visfatin expression analysis in association with recruitment and activation of human and rodent brown and brite adipocytes (2016) (9)
- Antipeptide antibody to the insulin-like growth factor-I receptor sequence 1232-1246 inhibits the receptor kinase activity. (1992) (9)
- Functional labeling of insulin receptor subunits in live cells. Alpha 2 beta 2 species is the major autophosphorylated form. (1989) (9)
- The insulin receptor kinase. (1985) (9)
- Insulin receptor: receptor activation and signal transduction. (1993) (8)
- Interaction of the C-terminal acidic domain of the insulin receptor with histone modulates the receptor kinase activity. (1995) (8)
- The insulin receptor: its structure and function. (1984) (8)
- A conformational change in the beta-subunit of the insulin-like growth factor I receptor identified by antipeptide antibodies. (1995) (8)
- Alteration of insulin receptor kinase in obese, insulin-resistant mice. (1987) (8)
- Insulin and tumor-promoting agent regulate an inhibitor of the 44-kDa mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1 in fibroblasts. (1993) (8)
- Insulin receptors: structure and function. (1986) (8)
- [Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates]. (1997) (7)
- The subunit structure of the insulin receptor and molecular interactions with major histocompatibility complex antigens. (1985) (7)
- Fasting, postprandial, and post-methionine-load homocysteinaemia and methylenetetrahydrofolate reductase polymorphism in vascular disease (1999) (7)
- [Neural tube defects and vitamin B12: a report of three cases]. (2004) (7)
- IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors. (2003) (7)
- Alterations in protein tyrosine kinase pathways in rat liver following normothermic ischemia-reperfusion. (2006) (7)
- Insulin receptor-induced phosphorylation of cellular and synthetic substrates is regulated by the receptor beta-subunit C-terminus. (1996) (7)
- Surface interactions and intracellular localization of cationic ferritin: similarity to 125I-insulin in 3T3-L1 adipocytes. (1983) (7)
- Insulin-like effects of vanadate on glucose uptake and on maturation in Xenopus laevis oocytes. (1991) (7)
- 125I-anti-insulin receptor Fab is internalized by cultured human lymphocytes. (1983) (7)
- Potential involvement of the carboxy-terminus of the Glut 1 transporter in glucose transport. (1992) (7)
- Amino acid-induced regulation of hepatocyte growth: possible role of Drosha (2019) (7)
- Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity (1992) (6)
- Role of the insulin receptor C-terminal acidic domain in the modulation of the receptor kinase by polybasic effectors. (1996) (6)
- Potential Involvement of FRS2 in Insulin Signaling1. (2000) (6)
- Tyrosine kinase activity of a chimeric insulin-like-growth-factor-1 receptor containing the insulin receptor C-terminal domain. Comparison with the tyrosine kinase activities of the insulin and insulin-like-growth-factor-1 receptors using a cell-free system. (1995) (6)
- Autoantibodies to the insulin receptor and insulin-resistant diabetes. (1982) (6)
- Effected of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice. (1995) (5)
- Assessment of Folate Status: Measurement of Homocysteine versus Vitamin B12 and Folate (2004) (5)
- Antiphosphotyrosine antibodies modulate insulin receptor kinase activity and insulin action. (1989) (5)
- Significance of cord-blood leptin in newborns of diabetic mothers. (2002) (5)
- Constitutive activation of the renin-angiotensin system reduces visceral fat and improves glucose tolerance in mice (2014) (4)
- Activation and regulation of the insulin receptor kinase. (1992) (3)
- [Signal transduction by the insulin receptor]. (1995) (3)
- Modulation of the insulin receptor by insulin receptor autoantibodies. (1980) (3)
- Calcium-antagonists and islet function. VI. Effects of barium. (1976) (3)
- The insulin receptor-kinase complex: an integrated system for transmembrane hormone signalling. (1984) (3)
- The Search for NIDDM genes project: a European Community programme aimed to facilitate the identification of NIDDM genes. (1998) (3)
- Two-dimensional polyacrylamide gel electrophoresis of the protease SP220K, a renal cell carcinoma marker (2000) (3)
- Argonaute-2 is associated to brown adipose tissue activation. (2019) (2)
- Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. (1998) (2)
- [microRNA and diabetes: tiny things causing huge effects]. (2013) (2)
- [The insulin receptor: mechanism of activation and message transmission]. (1992) (2)
- [Homocysteinemia and thrombophilic factors in unexplained decompression sickness]. (2006) (2)
- The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again (2019) (2)
- [Call for researchers associated with a biological study of neural tube defects: prospective study of the role of homocysteine in neural tube defects in France]. (2003) (1)
- The structure of the insulin receptor: studies using external and internal labeling techniques. (1983) (1)
- [Mechanism of insulin action]. (1995) (1)
- Effect of an alpha-glycosidase inhibitor on experimentally-induced obesity in mice. (1990) (1)
- [Insulin resistance: lessons from animal models of obesity]. (1996) (1)
- [Clinical relevance of homocysteine monitoring in the diabetic patient]. (2002) (1)
- [Antibodies directed against the insulin receptor and insulin-resistant diabetes]. (1980) (0)
- [Blood levels of homocysteine in patients under 55 years of age with acute coronary insufficiency]. (1997) (0)
- [Folates, vitamin B12, homocysteine and neural tube defects]. (2001) (0)
- ANTI-APOPTOTIC PI3-K/PKB PATHWAY IS INACTIVATED AFTER NORMOTHERMIC LIVER ISCHEMIA-REPERFUSION (2004) (0)
- How Does Our Knowledge on the Na+/H+ Exchanger NHE1 Obtained by Biochemical and Molecular Analyses Keep up With Its Recent Structure Determination? (2022) (0)
- [Thrombophilic factors in divers with undeserved decompression sickness]. (2006) (0)
- [The insulin receptor: an autonomous transfer system of the hormonal message?]. (1984) (0)
- [Troponin Ic and renal insufficiency]. (2005) (0)
- [Nuclear FoxO1 as a bridge between metabolism and mitogenesis]. (2008) (0)
- [The insulin receptor: an autonomous system for membrane transmission of the hormonal message]. (1984) (0)
- [Development of insulin resistance in muscle and adipose tissue during obesity in the mouse. Role of phosphatidylinositol 3-kinase]. (1995) (0)
- [Insulin receptor and action mechanism of the hormone]. (1989) (0)
- [Insulin receptors: activators and signalling]. (1993) (0)
- Polypeptide hormones: pathology and clinical aspects. (1984) (0)
This paper list is powered by the following services:
