Eric Betzig

About

From Wikipedia

Robert Eric Betzig is an American physicist who works as a professor of physics and professor of molecular and cell biology at the University of California, Berkeley. He is also a senior fellow at the Janelia Farm Research Campus in Ashburn, Virginia.

Published Works

• Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
• High-density mapping of single-molecule trajectories with photoactivated localization microscopy
• Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination
• Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
• Applying systems-level spectral imaging and analysis to reveal the organelle interactome
• Adaptive optics via pupil segmentation for high-resolution imaging in biological tissues
• Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
• Imaging Live-Cell Dynamics and Structure at the Single-Molecule Level
• Self-Organization of the Escherichia coli Chemotaxis Network Imaged with Super-Resolution Light Microscopy
• Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens
Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines
3D live fluorescence imaging of cellular dynamics using Bessel beam plane illumination microscopy
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
High-density three-dimensional localization microscopy across large volumes
Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales
Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse
Rapid adaptive optical recovery of optimal resolution over large volumes
High-speed, low-photodamage nonlinear imaging using passive pulse splitters
Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution
Nonmuscle Myosin II Isoforms Coassemble in Living Cells
Carbofluoresceins and Carborhodamines as Scaffolds for High-Contrast Fluorogenic Probes
3D imaging of Sox2 enhancer clusters in embryonic stem cells
Near-field diffraction by a slit: implications for superresolution microscopy
A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells
Visualizing dynamic microvillar search and stabilization during ligand detection by T cells
Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue
Optical spectroscopy of a GaAs/AlGaAs quantum wire structure using near‐field scanning optical microscopy
Single Molecules, Cells, and Super-Resolution Optics (Nobel Lecture)
Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse
Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells
Facile and General Synthesis of Photoactivatable Xanthene Dyes
Advances in the speed and resolution of light microscopy
Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation
Design and implementation of a low temperature near‐field scanning optical microscope
A plasma membrane template for macropinocytic cups
Subnuclear segregation of genes and core promoter factors in myogenesis
Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the Drosophila Male Germline
Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy
Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments
Myosin 18A Coassembles with Nonmuscle Myosin 2 to Form Mixed Bipolar Filaments
Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes
Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen
Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos
Dynamic super-resolution structured illumination imaging in the living brain
Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
Pupil-segmentation-based adaptive optical microscopy with full-pupil illumination
Cytoskeletal Control of Antigen-Dependent T Cell Activation
Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth
Excitation strategies for optical lattice microscopy
High-resolution imaging reveals how the spindle midzone impacts chromosome movement
Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells
Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus
Nobel Lecture: Single molecules, cells, and super-resolution optics
Nanostructure of supported phospholipid monolayers and bilayers by scanning probe microscopy
Photoactivated Localization Microscopy (PALM) of Adhesion Complexes
Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules
Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner
Facile and General Synthesis of Photoactivatable Xanthene Dyes
3D ATAC-PALM: super-resolution imaging of the accessible genome
V-1 regulates capping protein activity in vivo
Cytoskeletal actin patterns shape mast cell activation
Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor
Response to Comment on “Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics”
4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell–derived intestinal organoids
Sparse and composite coherent lattices
Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?
Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure
Einzelne Moleküle, Zellen und superhochauflösende Optik (Nobel-Aufsatz)
Endocytic Clathrin Coats Develop Curvature at Early Stages of Their Formation
Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans
Nonmuscle Myosin II Isoforms Coassemble in Living Cells
Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin
Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms
Photoactivated Localization Microscopy (PALM) of Adhesion Complexes
Erratum: High-speed, low-photodamage nonlinear imaging using passive pulse splitters
u-track 3D: measuring and interrogating intracellular dynamics in three dimensions
Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells
DEVELOPING PHOTOACTIVATED LOCALIZATION MICROSCOPY (PALM)
Imaging Life at High Spatiotemporal Resolution
Optical microscopy beyond the diffraction limit
Imaging Cellular Structure and Dynamics from Molecules to Organisms
Three-dimensional actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes
Tiled Reconstruction Improves Structured Illumination Microscopy
APC mutant cells exploit compensatory chromosome alterations to restore tumour cell fitness
Aurora B is required for programmed variations of cytokinesis during morphogenesis in the C. elegans embryo
Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution
Augmin-mediated amplification of long-lived spindle microtubules directs plus-ends to kinetochores
Pupil-segmentation-based adaptive optics for microscopy
Pupil-Segmentation-Based Adaptive Optics for Microscopy
in vivo Brain Imaging with Adaptive Optical Microscope
Opening a Path to Commercialization
Author response: 3D imaging of Sox2 enhancer clusters in embryonic stem cells
Author response: Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
Author response: Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes
Self-Organization of the Escherichia Coli Chemotaxis Network Imaged with Super-Resolution Light Microscopy
In Vivo Imaging of Cellular Dynamics from the Nanoscale to the Macroscale
Visualizing Dynamic Microvillar Search and Stabilization during Ligand Detection by T Cells
4D Cell Biology: Big Data Image Analytics and Lattice Light-Sheet Imaging Reveal Dynamics of Clathrin-Mediated Endocytosis in Stem Cell-Derived Intestinal Organoids
Top tips on scanning probes
4D cell biology: Big data image analytics and lattice light‐sheet imaging reveal dynamics of clathrin‐mediated endocytosis in stem cell‐derived intestinal organoids
Lamellar junctions in the endolymphatic sac act as a relief valve to regulate inner ear pressure
Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration kinetics in the zebrafish retina
Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging
Rule-governed Dynamic Stochastic Equilibration of Multicellular MotionIn VivoDuring Olfactory Neurogenesis
3D Deep Convolutional Neural Networks in Lattice Light-Sheet Data Puncta Segmentation
Dual-color superresolution imaging using genetically expressed probes
Single molecules, cells, and super-resolution optics (Presentation Video)
Near-Field Imaging of Fluorescence
Imaging life at High Spatiotemporal Resolution
Rapid Adaptive Optical Recovery of Diffraction-Limited Resolution Over Large Multicellular Volumes
Dynamic Superresolution Optical Lattice Microscopy
Zonal Adaptive Optical Microscopy
Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-Lapse Imaging
A Proliferative to Invasive Switch is Mediated by srGAP1 Downregulation Through the Activation of TGFβ2 Signaling
Author response: Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
Author response: A plasma membrane template for macropinocytic cups
Author response: Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure
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Other Resources

• en.wikipedia.org
• www.hhmi.org

Schools

California Institute of Technology

Private research university located in Pasadena, California

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Cornell University

Private university in Ithaca

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