Eric Kool
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American chemist
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Eric Koolchemistry Degrees
Chemistry
#2180
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#3049
Historical Rank
#689
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Organic Chemistry
#374
World Rank
#443
Historical Rank
#95
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Chemistry
Eric Kool's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Eric Kool Influential?
(Suggest an Edit or Addition)According to Wikipedia, Eric T. Kool is an American chemist, focusing in chemistry of RNA and DNA; probe design and imaging; synthetic biology, currently the George A. and Hilda M. Daubert Professor in Chemistry at Stanford University and is an Elected Fellow at the American Association for the Advancement of Science. He received the Beckman Young Investigators Award in 1992. He is the 2019 recipient of the Murray Goodman Memorial Prize
Eric Kool's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Structural imprints in vivo decode RNA regulatory mechanisms (2015) (488)
- Hydrogen bonding, base stacking, and steric effects in dna replication. (2001) (426)
- Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA. (2000) (378)
- Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. (1996) (376)
- RNA SHAPE analysis in living cells. (2013) (345)
- Escherichia coli RNA polymerase activity observed using atomic force microscopy. (1997) (342)
- Active site tightness and substrate fit in DNA replication. (2002) (337)
- Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis. (2017) (331)
- Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. (2015) (281)
- Replacing the nucleobases in DNA with designer molecules. (2002) (274)
- Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides. (1997) (258)
- DNA-multichromophore systems. (2012) (253)
- A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity. (1997) (240)
- Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication. (1997) (234)
- Fluorescent DNA base replacements: Reporters and sensors for biological systems. (2006) (217)
- Efficient replication between non-hydrogen-bonded nucleoside shape analogs (1998) (213)
- Detecting RNA and DNA with templated chemical reactions. (2006) (193)
- A specific partner for abasic damage in DNA (1999) (192)
- Experimental Measurement of Aromatic Stacking Affinities in the Context of Duplex DNA. (1996) (189)
- Fluorescent nucleobases as tools for studying DNA and RNA. (2017) (180)
- Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. (2005) (179)
- Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA. (1995) (175)
- A Four-Base Paired Genetic Helix with Expanded Size (2003) (175)
- The Discovery of Rolling Circle Amplification and Rolling Circle Transcription. (2016) (168)
- Naphthalene, Phenanthrene, and Pyrene as DNA Base Analogues: Synthesis, Structure, and Fluorescence in DNA. (1996) (159)
- Water-soluble organocatalysts for hydrazone and oxime formation. (2013) (152)
- Probing DNA sequences in solution with a monomer-excimer fluorescence color change. (1998) (149)
- Origins of the large differences in stability of DNA and RNA helices: C-5 methyl and 2'-hydroxyl effects. (1995) (146)
- Selective and Stable DNA Base Pairing without Hydrogen Bonds. (1998) (145)
- Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidine and Purine Nucleosides. (1994) (131)
- Chemical and structural effects of base modifications in messenger RNA (2017) (130)
- Efficient nucleic acid detection by templated reductive quencher release. (2009) (130)
- RNA structure maps across mammalian cellular compartments (2019) (130)
- Fluorescent DNA-based enzyme sensors. (2011) (129)
- Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations (2001) (127)
- Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. (1995) (125)
- Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes. (2006) (124)
- General method for modification of liposomes for encoded assembly on supported bilayers. (2005) (122)
- Minor Groove Interactions between Polymerase and DNA: More Essential to Replication than Watson-Crick Hydrogen Bonds? (1999) (120)
- Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backbone. (2011) (117)
- Fast hydrazone reactants: electronic and acid/base effects strongly influence rate at biological pH. (2013) (116)
- Imaging of RNA in bacteria with self-ligating quenched probes. (2002) (114)
- Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine. (2004) (114)
- Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems. (2007) (105)
- Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength. (2009) (104)
- Amplified microRNA detection by templated chemistry (2012) (104)
- Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA. (2000) (101)
- Solution structure of a DNA duplex containing a replicable difluorotoluene–adenine pair (1998) (101)
- Probing the active site tightness of DNA polymerase in subangstrom increments. (2005) (101)
- Libraries of composite polyfluors built from fluorescent deoxyribosides. (2002) (99)
- Quencher as leaving group: efficient detection of DNA-joining reactions. (2002) (99)
- Functional hydrogen-bonding map of the minor groove binding tracks of six DNA polymerases. (2000) (94)
- The Phe-X-Glu DNA Binding Motif of MutS (2001) (89)
- Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution. (2004) (88)
- Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. (2004) (85)
- Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity (2004) (84)
- Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA. (2013) (84)
- Quenching of Fluorescent Nucleobases by Neighboring DNA: The “Insulator” Concept (2008) (84)
- Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing. (2004) (83)
- 7SK-BAF axis controls pervasive transcription at enhancers (2016) (82)
- Quenched probes for highly specific detection of cellular RNAs. (2005) (81)
- Replication of non‐hydrogen bonded bases by DNA polymerases: A mechanism for steric matching (1998) (80)
- Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries (2021) (80)
- Modified DNA analogues that sense light exposure with color changes. (2004) (80)
- Importance of ortho proton donors in catalysis of hydrazone formation. (2013) (78)
- Asymmetric Recognition of DNA Local Distortion (2001) (76)
- RNA major groove modifications improve siRNA stability and biological activity (2008) (76)
- Molecular recognition by circular oligonucleotides: increasing the selectivity of DNA binding (1991) (76)
- Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA. (2005) (75)
- New Organocatalyst Scaffolds with High Activity in Promoting Hydrazone and Oxime Formation at Neutral pH (2014) (74)
- The difluorotoluene debate--a decade later. (2006) (73)
- Model systems for understanding DNA base pairing. (2007) (73)
- A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs. (2005) (72)
- Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set. (2008) (72)
- Circular oligonucleotides: new concepts in oligonucleotide design. (1996) (71)
- Direct fluorescence monitoring of DNA base excision repair. (2012) (71)
- Requirement of Watson-Crick Hydrogen Bonding for DNA Synthesis by Yeast DNA Polymerase η (2003) (71)
- Generation of catalytic RNAs by rolling transcription of synthetic DNA nanocircles (1997) (71)
- Helix-forming properties of size-expanded DNA, an alternative four-base genetic form. (2005) (70)
- yDNA: a new geometry for size-expanded base pairs. (2004) (70)
- Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes. (2000) (70)
- 7‐Azidomethoxy‐Coumarins as Profluorophores for Templated Nucleic Acid Detection (2008) (69)
- Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA (2005) (69)
- Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase. (2006) (69)
- Synthetically modified DNAs as substrates for polymerases. (2000) (67)
- Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. (2006) (66)
- Selective pairing of polyfluorinated DNA bases. (2004) (66)
- Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine. (1998) (66)
- Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets. (2009) (65)
- Evolving a polymerase for hydrophobic base analogues. (2009) (65)
- Efficient quenching of oligomeric fluorophores on a DNA backbone. (2007) (64)
- Dichotomous salt effects in the hydrophobic acceleration of the benzoin condensation (1988) (64)
- Multispectral labeling of antibodies with polyfluorophores on a DNA backbone and application in cellular imaging (2011) (63)
- Pattern-based detection of toxic metals in surface water with DNA polyfluorophores. (2014) (63)
- Novel benzopyrimidines as widened analogues of DNA bases. (2005) (63)
- Recognition of DNA, RNA, and Proteins by Circular Oligonucleotides. (1998) (63)
- Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system. (2005) (62)
- Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs. (2006) (62)
- Oligomeric fluorescent labels for DNA. (2005) (61)
- Structural Effects in the Recognition of DNA by Circular Oligonucleotides. (1992) (60)
- Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. (2003) (60)
- Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites. (2002) (60)
- Functional Evidence for a Small and Rigid Active Site in a High Fidelity DNA Polymerase (2006) (59)
- Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission. (2007) (58)
- High-fidelity in vivo replication of DNA base shape mimics without Watson–Crick hydrogen bonds (2003) (58)
- Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base. (1999) (57)
- Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs. (1994) (57)
- Structural Optimization of Non-Nucleotide Loop Replacements for Duplex and Triplex DNAs. (1995) (57)
- High sequence fidelity in a non-enzymatic DNA autoligation reaction. (1999) (57)
- Relative stabilities of triple helices composed of combinations of DNA, RNA and 2'-O-methyl-RNA backbones: chimeric circular oligonucleotides as probes. (1995) (56)
- Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine. (1997) (56)
- Oriented, active Escherichia coli RNA polymerase: an atomic force microscope study. (1999) (56)
- Encoding phenotype in bacteria with an alternative genetic set. (2011) (56)
- Fast Alpha Nucleophiles: Structures that Undergo Rapid Hydrazone/Oxime Formation at Neutral pH (2014) (56)
- Remarkable sensitivity to DNA base shape in the DNA polymerase active site. (2006) (56)
- Comparison of SHAPE reagents for mapping RNA structures inside living cells (2017) (55)
- Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix. (2006) (55)
- Evidence for a Watson-Crick Hydrogen Bonding Requirement in DNA Synthesis by Human DNA Polymerase κ (2005) (52)
- Large-Scale Detection of Metals with a Small Set of Fluorescent DNA-Like Chemosensors (2014) (51)
- Polyfluorophores on a DNA backbone: sensors of small molecules in the vapor phase. (2010) (50)
- Solution structure of xDNA: a paired genetic helix with increased diameter. (2004) (50)
- Convergent DNA synthesis: a non-enzymatic dimerization approach to circular oligodeoxynucleotides. (1995) (50)
- Origins of high sequence selectivity: a stopped-flow kinetics study of DNA/RNA hybridization by duplex- and triplex-forming oligonucleotides. (1995) (50)
- RNA structural analysis by evolving SHAPE chemistry (2014) (50)
- Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes (1998) (50)
- Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. (2003) (49)
- Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides. (2006) (49)
- Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone. (2013) (47)
- A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties. (2005) (47)
- Rapid and Selective Selenium-Mediated Autoligation of DNA Strands (2000) (46)
- Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. (2018) (45)
- A γ-cyclodextrin thiazolium salt holoenzyme mimic for the benzoin condensation (1988) (45)
- Efficient replication bypass of size-expanded DNA base pairs in bacterial cells. (2009) (45)
- Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. (2004) (45)
- Artificial genetic sets composed of size-expanded base pairs. (2013) (45)
- DNA Binding Properties of the Yeast Msh2-Msh6 and Mlh1-Pms1 Heterodimers (2002) (45)
- Selective sensor for silver ions built from polyfluorophores on a DNA backbone. (2010) (44)
- Chemical and enzymatic properties of bridging 5'-S-phosphorothioester linkages in DNA (1998) (44)
- Measurement and theory of hydrogen bonding contribution to isosteric DNA base pairs. (2012) (44)
- Versatile 5'-functionalization of oligonucleotides on solid support: amines, azides, thiols, and thioethers via phosphorus chemistry. (2004) (44)
- Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization. (2007) (43)
- Non-hydrogen bonding 'terminator' nucleosides increase the 3'-end homogeneity of enzymatic RNA and DNA synthesis. (1996) (43)
- Multi-path quenchers: efficient quenching of common fluorophores. (2011) (43)
- Organocatalytic Removal of Formaldehyde Adducts from RNA and DNA Bases (2015) (42)
- Chemistry of nucleic acids: impacts in multiple fields. (2011) (42)
- Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase-DNA complex. (2001) (42)
- Fluorescent DNAs printed on paper: sensing food spoilage and ripening in the vapor phase (2012) (42)
- The roles of hydrogen bonding and sterics in RNA interference. (2006) (41)
- Importance of terminal base pair hydrogen-bonding in 3'-end proofreading by the Klenow fragment of DNA polymerase I. (2000) (41)
- A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs. (1997) (41)
- Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker. (2016) (40)
- C-Nucleosides Derived from Simple Aromatic Hydrocarbons. (1997) (40)
- Two successive reactions on a DNA template: a strategy for improving background fluorescence and specificity in nucleic acid detection. (2011) (40)
- Polyfluorophore excimers and exciplexes as FRET donors in DNA. (2009) (40)
- Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides. (1995) (39)
- Organometallic activation of a fluorogen for templated nucleic acid detection. (2008) (39)
- Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. (2006) (39)
- A porphyrin C-nucleoside incorporated into DNA. (2002) (39)
- Importance of Hydrogen Bonding for Efficiency and Specificity of the Human Mitochondrial DNA Polymerase* (2008) (39)
- RNA Control by Photoreversible Acylation. (2018) (39)
- Enzymatic Synthesis of Fluorescent Oligomers Assembled on a DNA Backbone (2006) (38)
- Molecular Recognition by Circular Oligonucleotides. Strong Binding of Single-stranded DNA and RNA. (1991) (38)
- Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. (2012) (38)
- The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides. (2011) (37)
- Recognition of Single-Stranded Nucleic Acids by Triplex Formation: The Binding of Pyrimidine-Rich Sequences. (1994) (37)
- Artificial human telomeres from DNA nanocircle templates (2002) (36)
- Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases. (2012) (36)
- DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. (2006) (36)
- Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY. (2008) (36)
- Improved templated fluorogenic probes enhance the analysis of closely related pathogenic bacteria by microscopy and flow cytometry. (2011) (36)
- A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing. (2002) (36)
- An efficient method for the synthesis of aromatic C-nucleosides (1995) (36)
- Pyrene nucleotide as a mechanistic probe: evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase. (2000) (35)
- Polymerase activities and RNA structures in the atomic force microscope. (1999) (35)
- Interaction and solvation energies of nonpolar DNA base analogues and their role in polymerase insertion fidelity. (1999) (34)
- Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity† †Electronic supplementary information (ESI) available: Supplementary tables and figures, experimental details, and synthetic procedures. See DOI: 10.1039/c8sc01082j (2018) (34)
- Targeting pyrimidine single strands by triplex formation: structural optimization of binding. (1995) (33)
- DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases. (2010) (32)
- Fluorescence quenchers for hydrazone and oxime orthogonal bioconjugation. (2012) (32)
- RNA Cloaking by Reversible Acylation. (2018) (32)
- Pattern-based detection of anion pollutants in water with DNA polyfluorophores (2015) (31)
- New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA. (2008) (30)
- Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase (2010) (30)
- DNA Recognition by Hybrid Oligoether-Oligodeoxynucleotide Macrocycles. (1992) (30)
- DNA polyfluorophores as highly diverse chemosensors of toxic gases (2011) (29)
- Fingerprints of Modified RNA Bases from Deep Sequencing Profiles. (2017) (29)
- Triplex-directed self-assembly of an artificial sliding clamp on duplex DNA. (1998) (29)
- Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular Aldehydic Load. (2016) (29)
- Luminescent Carbon Dot Mimics Assembled on DNA. (2017) (29)
- RNA‐Templated Chemistry in Cells: Discrimination of Escherichia, Shigella and Salmonella Bacterial Strains With a New Two‐Color FRET Strategy (2006) (28)
- Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. (2014) (28)
- Chemical fidelity of an RNA polymerase ribozyme (2013) (28)
- The chemistry and applications of RNA 2′-OH acylation (2019) (28)
- Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. (2010) (28)
- Protease probes built from DNA: multispectral fluorescent DNA-peptide conjugates as caspase chemosensors. (2011) (27)
- Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection (2003) (27)
- DNA and aspects of molecular biology (2002) (27)
- Steric effects in RNA interference: probing the influence of nucleobase size and shape. (2008) (27)
- Polymerase Amplification, Cloning, and Gene Expression of Benzo‐Homologous “yDNA” Base Pairs (2008) (26)
- DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems. (2012) (26)
- Monitoring eukaryotic and bacterial UDG repair activity with DNA-multifluorophore sensors (2013) (25)
- Fluorogenic Templated Reaction Cascades for RNA Detection. (2017) (25)
- A simple method for electrophilic functionalization of DNA. (2002) (25)
- Differentiating a diverse range of volatile organic compounds with polyfluorophore sensors built on a DNA scaffold. (2011) (24)
- Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a phosphorothioate linkage. (2002) (24)
- Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities. (2004) (24)
- Color-Change Photoswitching of an Alkynylpyrene Excimer Dye. (2017) (24)
- Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines. (2007) (24)
- Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity (2016) (23)
- The model student: what chemical model systems can teach us about biology. (2007) (23)
- Sandwich probes: two simultaneous reactions for templated nucleic acid detection. (2010) (22)
- Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases. (2012) (22)
- Stabilities of nucleotide loops bridging the pyrimidine strands in DNA pyrimidine.purine.pyrimidine triplexes: special stability of the CTTTG loop. (1994) (22)
- Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs. (2010) (22)
- Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A tracts. (2004) (21)
- Fluorescent Probes of DNA Repair. (2017) (21)
- Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. (2007) (21)
- Efficient bacterial transcription of DNA nanocircle vectors with optimized single-stranded promoters (2001) (21)
- Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: confirmation by 'inverse' sequencing. (1997) (21)
- A set of nonpolar thymidine nucleoside analogues with gradually increasing size. (2004) (20)
- Fluorous base-pairing effects in a DNA polymerase active site. (2005) (20)
- In Vitro Fluorogenic Real‐Time Assay of the Repair of Oxidative DNA Damage (2015) (20)
- Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1. (2020) (20)
- Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection (2020) (20)
- Nonpolar nucleoside mimics as active substrates for human thymidine kinases. (2009) (19)
- Templated Chemistry for Sequence‐Specific Fluorogenic Detection of Duplex DNA (2010) (19)
- Formation of Stable DNA Loops by Incorporation of Nonpolar, Non-Hydrogen-Bonding Nucleoside Isosteres. (1996) (19)
- Base pairing and steric interactions between pyrimidine strand bridging loops and the purine strand in DNA pyrimidine.purine.pyrimidine triplexes. (1994) (19)
- Fluorescent DNA chemosensors: identification of bacterial species by their volatile metabolites. (2011) (19)
- Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes (2018) (18)
- Polyfluorophore labels on DNA: dramatic sequence dependence of quenching. (2009) (18)
- Light-Up "Channel Dyes" for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells. (2016) (18)
- Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues (2014) (18)
- Replacing the Nucleobases in DNA with Designer Molecules (2003) (17)
- Strong binding of single-stranded DNA by stem-loop oligonucleotides. (1992) (17)
- Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses. (2018) (17)
- Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response (2016) (17)
- DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides (2016) (17)
- Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis. (2008) (16)
- Base Pair Hydrogen Bonds Are Essential for Proofreading Selectivity by the Human Mitochondrial DNA Polymerase* (2008) (16)
- Chemical and Enzymatic Methods for Preparing Circular Single‐Stranded DNAs (2000) (16)
- The virtues of self-binding: high sequence specificity for RNA cleavage by self-processed hammerhead ribozymes. (2000) (16)
- Reversible RNA acylation for control of CRISPR–Cas9 gene editing† (2019) (15)
- DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases. (2017) (15)
- Synthesis and Properties of Size‐Expanded DNAs: Toward Designed, Functional Genetic Systems (2007) (15)
- A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target. (2016) (15)
- Double displacement: An improved bioorthogonal reaction strategy for templated nucleic acid detection. (2010) (15)
- Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA polymerase. (2011) (15)
- Structure and Replication of yDNA: A Novel Genetic Set Widened by Benzo‐Homologation (2009) (14)
- Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1. (2019) (13)
- Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties. (2019) (13)
- Guanine‐Rich DNA Nanocircles for the Synthesis and Characterization of Long Cytosine‐Rich Telomeric DNAs (2005) (13)
- Interaction of the bacteriophage Mu transcriptional activator protein, C, with its target site in the mom promoter. (1997) (13)
- DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase Identification of Petroleum Products in Contaminated Soil. (2013) (13)
- Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. (2019) (13)
- Erratum: Structural imprints in vivo decode RNA regulatory mechanisms (2015) (13)
- Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T. (2003) (13)
- Templated chemistry for monitoring damage and repair directly in duplex DNA. (2012) (13)
- Detecting RNA and DNA with Templated Chemical Reactions (2006) (12)
- Solvent, pH, and Ionic Effects on the Binding of Single-Stranded DNA by Circular Oligodeoxynucleotides. (1994) (12)
- Chemistry of Nucleic Acids: Impacts in Multiple Fields (2011) (12)
- Selective Fluorogenic Chemosensors for Distinct Classes of Nucleases (2013) (12)
- ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling. (2016) (12)
- Mimicry of the hepatitis delta virus replication cycle mediated by synthetic circular oligodeoxynucleotides. (1999) (12)
- Visualization of long human telomere mimics by single-molecule fluorescence imaging. (2008) (12)
- The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors (2019) (12)
- Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli. (2007) (11)
- Binding of Two Different DNA Sequences by Conformational Switching. (1993) (11)
- Correction to "Structure and Thermodynamics of N(6)-Methyladenosine in RNA: A Spring-Loaded Base Modification". (2015) (11)
- Generation of RNA ladders by rolling circle transcription of small circular oligodeoxyribonucleotides. (1998) (11)
- The Difluorotoluene Debate — A Decade Later (2007) (11)
- Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera (2017) (10)
- Circular Antisense Oligonucleotides Inhibit Growth of Chronic Myeloid Leukemia Cells (1999) (10)
- RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase. (2007) (10)
- An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs. (2002) (10)
- Site-selective RNA Functionalization via DNA-induced Structure. (2020) (10)
- Nonpolar Nucleobase Analogs Illuminate Requirements for Site-specific DNA Cleavage by Vaccinia Topoisomerase* (2006) (10)
- A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status. (2019) (10)
- Mimicking the Structure and Function of DNA: Insights into DNA Stability and Replication (2000) (10)
- DNA curvature at A tracts containing a non-polar thymine mimic. (2003) (10)
- Simple alkanoyl acylating agents for reversible RNA functionalization and control. (2019) (10)
- Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision. (2019) (10)
- Epigenetics: A new methyl mark on messengers (2016) (10)
- Trapping Transient RNA Complexes by Chemically Reversible Acylation. (2020) (9)
- Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03901a (2019) (9)
- Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B. (2004) (8)
- Fluorescent DNA‐Based Enzyme Sensors (2012) (8)
- Recognition of RNA by triplex formation: divergent effects of pyrimidine C-5 methylation. (1997) (8)
- Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells (2019) (8)
- Quenched autoligation probes. (2008) (7)
- Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses. (2021) (7)
- Polymerase synthesis of four-base DNA from two stable dimeric nucleotides (2019) (7)
- Kinetics and binding of the thymine-DNA mismatch glycosylase, Mig-Mth, with mismatch-containing DNA substrates. (2003) (7)
- New designs for DNA bases: expanded DNAs and oligofluorosides. (2006) (7)
- Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication. (2000) (7)
- Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes (2021) (7)
- A self-cleaving DNA nucleoside (1997) (6)
- DNA tiling enables precise acylation-based labeling and control of mRNA. (2021) (6)
- DNA Binding Properties of the Yeast Msh 2-Msh 6 and Mlh 1-Pms 1 Heterodimers (2004) (6)
- Modified DNA Bases: Probing Base‐Pair Recognition by Polymerases (2008) (6)
- Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores. (2016) (6)
- A Highly Effective Nonpolar Isostere of Deoxyguanosine (I): Synthesis, Structure, Stacking, and Base Pairing. (2003) (5)
- Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA. (2018) (5)
- Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase (2005) (5)
- Integrating transcription factor abundance with chromatin accessibility in human erythroid lineage commitment (2021) (5)
- DESIGN OF TRIPLEX-FORMING OLIGONUCLEOTIDES FOR BINDING DNA AND RNA : OPTIMIZING AFFINITY AND SELECTIVITY (1997) (5)
- Chapter 1:Designer bases, base pairs, and genetic sets: biochemical and biological activity (2014) (5)
- Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization. (2008) (4)
- OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. (2021) (4)
- Strong, Specific Binding of Six Different DNA Sequences by a Single Conformation-Switching DNA Macrocycle. (1994) (4)
- An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1. (2020) (4)
- Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity (2020) (4)
- Topological modification of oligonucleotides for potential inhibition of gene expression (1996) (4)
- Accelerated displacement of duplex DNA strands by a synthetic circular oligodeoxynucleotide (1993) (4)
- Universal linkers for signal amplification in auto-ligating probes. (2005) (4)
- Acylation probing of "generic" RNA libraries reveals critical influence of loop constraints on reactivity. (2022) (3)
- Correction: Pattern-based detection of anion pollutants in water with DNA polyfluorophores (2015) (3)
- Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions. (2020) (3)
- N6-Methyladenosine RNA (2015) (3)
- Nonenzymatic DNA ligation in Escherichia coli cells. (2002) (3)
- Towards the replication of xDNA, a size-expanded unnatural genetic system. (2008) (3)
- Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution (2016) (3)
- Pervasive Transcriptome Interactions of Protein-Targeted Drugs (2023) (2)
- Conjugation of RNA via 2'-OH acylation: Mechanisms determining nucleotide reactivity. (2022) (2)
- Multiple Pathway Quenchers: Efficient Quenching of Common Fluorophores (2011) (2)
- ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. (2018) (2)
- Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. (2022) (2)
- Integrating transcription-factor abundance with chromatin accessibility in human erythroid lineage commitment (2022) (2)
- Topologically Modified Biopolymers: Properties of Synthetic Circular DNAs and RNAs. (1995) (2)
- 5′‐Iodination of Solid‐Phase‐Linked Oligodeoxyribonucleotides (2003) (2)
- Fluorescent DNA Base Replacements: Reporters and Sensors for Biological Systems (2007) (1)
- DNA WITH PYRENE PAIRED AT ABASIC SITES (2000) (1)
- Efficient DNA fluorescence labeling via base excision trapping (2022) (1)
- Accelerated Publications Escherichia coli RNA Polymerase Activity Observed Using Atomic Force Microscopy † (1997) (1)
- Syntheses and properties of low-polarity shape mimics of 8-oxopurines. (2007) (1)
- Water‐Soluble Organocatalysts for Hydrazone and Oxime Formation. (2013) (1)
- Corrigendum: Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. (2015) (1)
- Use of Multiple Fluorescent Labels in Biological Sensing (2006) (1)
- Correction to "Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone". (2017) (0)
- Small Molecule Inhibitor of 8-oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during P. aeruginosa Infection (2020) (0)
- Biopolymers: Editorial overview (1998) (0)
- id oxime and hydrazone formation promoted by catalytic amine bu ff ers with low toxicity † (2018) (0)
- Mechanism-Based Strategy for Optimizing HaloTag Protein Labeling (2022) (0)
- New Designs for DNA Bases: Expanded DNAs and Oligofluorosides (2008) (0)
- Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries (2021) (0)
- Nonpolar nucleosides alter RNA Polymerase II NTP specificity by disrupting hydrogen bonding and base stacking (2012) (0)
- New Multilabel Fluorescent Groups for Increased Sensitivity of DNA Detection. (1996) (0)
- Control of RNA with quinone methide reversible acylating reagents. (2021) (0)
- Organomercury-Induced Fluorogenic Unmasking for BiologicalSensing (2008) (0)
- Interactions of Multiple Fluorescent Labels in Biological Sensing (2003) (0)
- Rolling Circle Transcription of Ribozymes Targeted to ras DAMD (0)
- Circular Oligonucleotides as Potential Modulators of Gene Expression (2017) (0)
- Chemical Tools for the Study of DNA Repair. (2022) (0)
- Correction to “Large-Scale Detection of Metals with a Small Set of Fluorescent DNA-Like Chemosensors” (2015) (0)
- Expanding the Functional Capabilities of Nucleic Acids by Molecular Design (1996) (0)
- Diverse Reagent Scaffolds Provide Differential Selectivity of 2'-OH Acylation in RNA. (2022) (0)
- 7.10 – Topological Modification of DNA: Circles, Loops, Knots,and Branches (1999) (0)
- A Set of Nonpolar Thymidine Nucleoside Analogues with Gradually Increasing Size (2005) (0)
- An Efficient Method for the Synthesis of Aromatic C-Nucleosides. (1995) (0)
- Abstract 5473: Towards a better understanding of MTH1 as a therapeutic target in RAS-driven cancer (2017) (0)
- CLiCk UpdatE tHpta Crystal struCture of Haloalkane DeHalogenase dNa CONjUgatiON tO HaLOtaggEd pROtEiN UsiNg gLEN BROMOHExyL LiNkER (2014) (0)
- Graphical contents list (2008) (0)
- A Self‐Cleaving DNA Nucleoside. (1997) (0)
- The importance of nucleotide size in the chemistry and biology of DNA (2008) (0)
- leaving group base pair recognition during polymerase nucleotide incorporation revealed by methylene substitution. (2016) (0)
- Sulfonylation of RNA 2′-OH groups (2023) (0)
- Orientation of single, active Escherichia coli RNA polymerase molecules for study with Atomic Force Microscopy (1997) (0)
- DNA tiling enables precise acylation‐based labeling and control of mRNA (2021) (0)
- 7.01 – Overview (1999) (0)
- RNA structure maps across mammalian cellular compartments (2019) (0)
- Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses (2021) (0)
- Site-specific RNA Functionalization via DNA-induced Structure (2020) (0)
- AD Award Number : DAMD 1798-1-8239 TITLE : Rolling Circle Transcription of Ribozymes Targeted to ras and mdr-1 PRINCIPAL INVESTIGATOR : (0)
- ESI Chemical fidelity of an RNA polymerase ribozyme c3sc50574j (2013) (0)
- Structure and Stability of RNAs Containing N6-Methyl-adenosine (2015) (0)
- Sensitive, Selective Fluorescent Probes for the Detection and Identification of Nucleic Acids (2001) (0)
- Rolling Circle Transcription of Ribozymes Targeted to ras and mdr-1 (2000) (0)
- Fluorescent detection of RNA using a base excision reporter (2022) (0)
- Fluorescent C‐Nucleosides and their Oligomeric Assemblies (2016) (0)
- Abstract 4790: Oxidation in the nucleotide pool as a novel targetable vulnerability in pancreatic ductal adenocarcinoma (2023) (0)
- Advances in DNA-based nanotechnology themed issue (2011) (0)
- Abstract 2076: Low OGG1 protects against the DNA damage induced by MTH1 inhibition (2021) (0)
- Crystal structure of DNA polymerase from Thermococcus gorgonarius in complex with hypoxanthine-containing DNA (2010) (0)
- Efficient Nucleic Acid Detection by Templated Reductive (2010) (0)
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