Erica Golemis
#150,783
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American oncologist
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#3487
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#208
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#216
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Erica Golemis's Degrees
- Doctorate Medicine Harvard University
Why Is Erica Golemis Influential?
(Suggest an Edit or Addition)According to Wikipedia, Erica A. Golemis is an American oncologist. She is the William Wikoff Smith Chair in Cancer Research at Fox Chase Cancer Center, as well as deputy chief science officer and co-leader of the molecular therapeutics program.
Erica Golemis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium (2007) (791)
- Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system (1994) (611)
- Correlation of two-hybrid affinity data with in vitro measurements (1995) (575)
- The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis* (1997) (363)
- Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer. (2015) (360)
- Aurora A kinase (AURKA) in normal and pathological cell division (2013) (352)
- Integrin signalling: a new Cas(t) of characters enters the stage. (2000) (305)
- MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. (1999) (258)
- Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae (1996) (240)
- The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome (2005) (237)
- Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22 (1997) (227)
- Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 (1999) (200)
- KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. (2002) (196)
- Fused protein domains inhibit DNA binding by LexA (1992) (185)
- CAS proteins in normal and pathological cell growth control (2010) (181)
- Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity. (1990) (180)
- Cell cycle-dependent ciliogenesis and cancer. (2008) (176)
- Primary cilia and the cell cycle. (2009) (174)
- AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation (1995) (173)
- Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides (1987) (164)
- Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. (2008) (163)
- Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets (2017) (160)
- HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (2007) (159)
- Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II (1998) (154)
- Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells (2002) (145)
- ArgBP2, a Multiple Src Homology 3 Domain-containing, Arg/Abl-interacting Protein, Is Phosphorylated in v-Abl-transformed Cells and Localized in Stress Fibers and Cardiocyte Z-disks* (1997) (140)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (1999) (139)
- NEDD9 promotes oncogenic signaling in mammary tumor development. (2009) (139)
- Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies (2010) (138)
- Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. (2004) (133)
- Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design (1990) (133)
- The Related Adhesion Focal Tyrosine Kinase Differentially Phosphorylates p130Cas and the Cas-like Protein, p105HEF1 * (1997) (129)
- Uses of lacZ to study gene function: evaluation of beta-galactosidase assays employed in the yeast two-hybrid system. (2000) (128)
- Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis (2012) (127)
- A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. (2007) (123)
- Cell Cycle-Regulated Processing of HEF1 to Multiple Protein Forms Differentially Targeted to Multiple Subcellular Compartments (1998) (119)
- Molecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycle (2007) (116)
- Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis (2016) (110)
- Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients (2019) (105)
- Ciliary signalling in cancer (2018) (104)
- Using the yeast interaction trap and other two-hybrid-based approaches to study protein-protein interactions. (2001) (104)
- A Two-hybrid Dual Bait System to Discriminate Specificity of Protein Interactions* (1999) (101)
- The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease (2015) (101)
- The extracellular matrix and ciliary signaling. (2012) (98)
- Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells* (1997) (98)
- Molecular mechanisms of the preventable causes of cancer in the United States (2018) (97)
- Differential Signaling after β1 Integrin Ligation Is Mediated Through Binding of CRKL to p120 CBL and p110 HEF1 * (1997) (95)
- The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites (2000) (94)
- Distinct segments within the enhancer region collaborate to specify the type of leukemia induced by nondefective Friend and Moloney viruses (1989) (93)
- HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression (2011) (92)
- Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion (2014) (91)
- Proteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion Dynamics (2001) (91)
- Dissection of HEF1-dependent functions in motility and transcriptional regulation. (2002) (91)
- Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel—Lindau protein (2003) (90)
- POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies (2016) (86)
- HEF1-Aurora A Interactions: Points of Dialog between the Cell Cycle and Cell Attachment Signaling Networks (2006) (85)
- Approaches to detecting false positives in yeast two-hybrid systems. (2000) (83)
- A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 (2000) (81)
- NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation (2011) (81)
- Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer (2019) (80)
- A novel Cas family member, HEPL, regulates FAK and cell spreading. (2008) (76)
- Targeting EGFR resistance networks in head and neck cancer. (2009) (76)
- Mechanisms of tumor resistance to EGFR-targeted therapies (2009) (76)
- Rapid calcium-dependent activation of Aurora-A kinase (2010) (75)
- Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology. (1995) (74)
- Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. (2000) (74)
- The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies (2013) (74)
- Focal adhesion kinase regulates β1 integrin‐dependent T cell migration through an HEF1 effector pathway (2001) (73)
- A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels (2003) (70)
- Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. (2015) (69)
- The continued evolution of two-hybrid screening approaches in yeast: how to outwit different preys with different baits. (2000) (69)
- HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (2006) (69)
- Selective Raf inhibition in cancer therapy (2007) (68)
- Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. (2005) (66)
- Aurora A kinase activity influences calcium signaling in kidney cells (2011) (65)
- Chemotherapy and signaling (2010) (65)
- Genomic insights into head and neck cancer (2016) (65)
- Interdependence of cell attachment and cell cycle signaling. (2006) (64)
- Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. (2003) (64)
- Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. (2013) (60)
- Aurora kinases in head and neck cancer. (2013) (60)
- Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. (2015) (58)
- Analysis of the Interaction of the Novel RNA Polymerase II (pol II) Subunit hsRPB4 with Its Partner hsRPB7 and with pol II (1998) (58)
- Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. (2001) (57)
- Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence (2017) (56)
- Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. (2020) (55)
- Two-Hybrid System and False Positives (2001) (53)
- Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. (1999) (53)
- Alternative yeast two-hybrid systems. The interaction trap and interaction mating. (1997) (52)
- The GDP Exchange Factor AND-34 Is Expressed in B Cells, Associates With HEF1, and Activates Cdc421 (2003) (50)
- Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway. (2001) (49)
- CAS proteins in health and disease: An update (2014) (48)
- Cilia and cilia-associated proteins in cancer. (2013) (48)
- Network Analysis Identifies an HSP90-Central Hub Susceptible in Ovarian Cancer (2013) (47)
- The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics (2009) (45)
- Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9. (2010) (44)
- The Centrosomal Kinase Plk1 Localizes to the Transition Zone of Primary Cilia and Induces Phosphorylation of Nephrocystin-1 (2012) (44)
- Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck (2019) (44)
- Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells. (1997) (43)
- Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease (2013) (43)
- Defects in DNA Repair Genes Confer Improved Long-term Survival after Cisplatin-based Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer. (2020) (42)
- EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer (2016) (41)
- Detection of peptides, proteins, and drugs that selectively interact with protein targets. (2002) (41)
- Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer. (2016) (40)
- The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1* (1999) (39)
- NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis (2017) (39)
- Relationship of increased aurora kinase A gene copy number, prognosis and response to chemotherapy in patients with metastatic colorectal cancer (2012) (38)
- Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease (2014) (38)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (2011) (37)
- HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins (2007) (35)
- Mechanisms for nonmitotic activation of Aurora-A at cilia. (2017) (35)
- Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer. (2011) (35)
- A functional association between merlin and HEI10, a cell cycle regulator (2006) (35)
- Analysis of Small GTPase Signaling Pathways Using p21-activated Kinase Mutants That Selectively Couple to Cdc42* (2001) (34)
- Two-hybrid system and false positives. Approaches to detection and elimination. (2001) (34)
- Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. (1996) (33)
- Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer (2019) (32)
- Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system. (2008) (32)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (1997) (32)
- Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer (2016) (32)
- DUSP6 regulates drug sensitivity by modulating DNA damage response (2013) (31)
- In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway– and microtubule-targeting inhibitors (2007) (31)
- Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. (2014) (30)
- Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein (2007) (30)
- Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas. (2015) (30)
- A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer (2015) (29)
- A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice (2014) (29)
- MED 1 , a novel human methyl-CpG-binding endonuclease , interacts with DNA mismatch repair protein MLH 1 (1999) (28)
- LexA-based two-hybrid systems. (2000) (28)
- Redefinition of the yeast two-hybrid system in dialogue with changing priorities in biological research. (2001) (27)
- The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily. (1999) (27)
- Autoinhibited proteins as promising drug targets (2004) (27)
- Nedd9 restrains renal cystogenesis in Pkd1−/− mice (2014) (26)
- The yeast two-hybrid system: criteria for detecting physiologically significant protein-protein interactions. (1999) (26)
- Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers (2013) (26)
- Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation (2016) (25)
- Protein interaction-targeted drug discovery: evaluating critical issues. (2002) (25)
- Streamlined yeast colorimetric reporter activity assays using scanners and plate readers. (2000) (25)
- Ganetespib limits ciliation and cystogenesis in autosomal‐dominant polycystic kidney disease (ADPKD) (2018) (25)
- Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members. (2015) (24)
- Basic methods in protein purification and analysis : a laboratory manual (2009) (24)
- Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer. (2016) (24)
- A Combined Yeast/Bacteria Two-hybrid System (2005) (24)
- Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death (2012) (24)
- A Novel HSP90 Inhibitor–Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer (2016) (23)
- The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation (2010) (22)
- Genomic analysis utilizing the yeast two-hybrid system. (2001) (22)
- Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development (2010) (20)
- Integrating in silico resources to map a signaling network. (2014) (19)
- Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods (2017) (19)
- Fibroblast-derived 3 D matrix differentially regulates the growth and drug-responsiveness of human cancer cells (2008) (19)
- Human Enhancer of Invasion-Cluster, a Coiled-Coil Protein Required for Passage through Mitosis (2004) (19)
- Issues in interpreting the in vivo activity of Aurora-A (2015) (19)
- Tumor-Targeted Drug Conjugates as an Emerging Novel Therapeutic Approach in Small Cell Lung Cancer (SCLC) (2019) (19)
- NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice (2018) (18)
- Phospho-T356RB1 predicts survival in HPV-negative squamous cell carcinoma of the head and neck (2015) (18)
- Disease-Associated Genetic Variation in Human Mitochondrial Protein Import. (2019) (17)
- PROTEIN-PROTEIN INTERACTIONS: a molecular cloning manual (2017) (17)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (2000) (17)
- Comment on “Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling” (2012) (16)
- X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis (2020) (16)
- Synthetic Lethal Targeting of Mitotic Checkpoints in HPV-Negative Head and Neck Cancer (2020) (16)
- Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease. (2019) (15)
- Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub 1 (2004) (15)
- Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. (2001) (15)
- From correlation to causality: microarrays, cancer, and cancer treatment. (2003) (14)
- Targeting the Epidermal Growth Factor Receptor in EGFR-Mutated Lung Cancer: Current and Emerging Therapies (2021) (14)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (1997) (14)
- Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs (2019) (14)
- Vectors to target protein domains to different cellular compartments. (1998) (13)
- Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer (2015) (13)
- Structure, stability, and function of hDim1 investigated by NMR, circular dichroism, and mutational analysis. (2003) (13)
- PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization (2019) (12)
- Defects in DNA repair genes and sensitivity to cisplatin based neoadjuvant chemotherapy (NAC) for bladder cancer. (2015) (12)
- Preclinical and clinical studies of the NEDD 9 scaffold protein in cancer and other diseases (2015) (12)
- Conversion of mRNA into Double‐Stranded cDNA (1995) (12)
- Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1 (2017) (12)
- Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers (2022) (12)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (1998) (11)
- Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models (2016) (11)
- Prevalence of pathogenic variants in DNA damage response and repair genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer (2020) (11)
- Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer. (2022) (11)
- Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice (2014) (10)
- Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model (2017) (10)
- HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression (2021) (10)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (2000) (10)
- Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin (2016) (10)
- Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease (2015) (10)
- Interaction of germline variants in a family with a history of early‐onset clear cell renal cell carcinoma (2019) (9)
- Basic methods in protein purification and analysis (2009) (9)
- Correlation of tumor mutational burden (TMB) with CDKN2A and TP53 mutation in HPV-negative head and neck squamous cell carcinoma (HNSCC). (2020) (9)
- Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC) (2021) (9)
- Interactions between the full complement of human RNA polymerase II subunits (1999) (9)
- Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription (1999) (9)
- Development of a Yeast Two-Hybrid Screen for Selection of Human Ras-Raf Protein Interaction Inhibitors (2005) (8)
- TumorNext: A comprehensive tumor profiling assay that incorporates high resolution copy number analysis and germline status to improve testing accuracy (2016) (8)
- Molecular Determinants of Head and Neck Cancer (2018) (8)
- EGFR and RB 1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer (2016) (7)
- Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome. (2016) (7)
- A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system (2004) (7)
- Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction. (2006) (7)
- Next-generation sequencing to identify molecular alterations in DNA repair and chromatin maintenance genes associated with pathologic complete response (pT0) to neoadjuvant accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC) in muscle-invasive bladder cancer (MIBC). (2014) (6)
- A two-hybrid approach to identify inhibitors of the RAS-RAF interaction. (2013) (6)
- EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer (2014) (6)
- The tumor suppressor FBW7 controls ciliary length (2015) (6)
- Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization (2015) (5)
- Signal transduction driving technology driving signal transduction: Factors in the design of targeted therapies (2001) (5)
- Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation (2019) (5)
- Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human transcription repressor ERH. (2005) (5)
- Summary Dissection of HEF 1-dependent functions in motility and transcriptional regulation (2002) (5)
- Overview: The Pathobiology of Head and Neck Cancer (2014) (5)
- The Yeast Two-Hybrid System for Detecting Interacting Proteins (2005) (4)
- Erratum: HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells (Oncogene (2006) 25, (1721-1732) DOI: 10.1038/sj.onc.1209199) (2007) (4)
- Control of ciliation in embryogenesis (2015) (4)
- A new strategy to ERADicate HER2-positive breast tumors? (2015) (4)
- The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors (2022) (4)
- Disease Specificity ofNondefective Friend andMoloneyMurine Leukemia Viruses IsControlled bya SmallNumberofNucleotides (1987) (3)
- Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer (2019) (3)
- A ciliary timer for S-phase entry (2007) (3)
- Encroaching genomics: adapting large-scale science to small academic laboratories. (2000) (3)
- Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. (2005) (3)
- Nedd9 Restrains Autophagy to Limit Growth of Early Stage Non–Small Cell Lung Cancer (2021) (3)
- Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression (2021) (3)
- Interaction Trap/Two‐Hybrid System to Identify Interacting Proteins (2008) (2)
- Targeting proteins to specific cellular compartments to optimize physiological activity. (2001) (2)
- Abstract 721: Expression of Aurora A and Phospho-Aurora-A is predictive of survival in patients with head and neck cancer (2012) (2)
- Patterns of Ciliation and Ciliary Signaling in Cancer. (2020) (2)
- Abstract 4298: Defects in DNA repair genes and sensitivity to cisplatin based neoadjuvant chemotherapy (NAC) for bladder cancer (2015) (2)
- Delineating the RAS Conformational Landscape (2022) (2)
- The role and targeting of Aurora kinases in head and neck cancer (2014) (2)
- Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models (2021) (2)
- Abstract 3469: Dual inhibition of the EGFR and Aurora A pathways in Kras mutated non-small cell lung cancers (2018) (2)
- Correlation of peripheral blood markers of DNA damage and immune response with chemoradiation response in patients with locally advanced rectal cancer. (2019) (2)
- NEDD9 sustains hexokinase expression to promote glycolysis (2022) (2)
- A bacterial/yeast merged two-hybrid system: protocol for bacterial screening. (2007) (2)
- Abstract 989: NEDD9 expression promotes epithelial ovarian cancer growth and dissemination (2014) (2)
- An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion (2019) (2)
- The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies (2012) (1)
- Role of Enhancer Regions in Leukemia Induction by Nondefective Murine C Type Retroviruses (1989) (1)
- Peripheral Blood Lymphocyte Gamma-H2AX as a Predictor for Treatment Response in Rectal Cancer Patients (2017) (1)
- Abstract 1584: Musashi-2 (MSI2) drives TGFBR1/SMAD3 dependent partial EMT and supports VEGFR2 expression and metastasis of human and mouse NSCLC cells (2016) (1)
- Defects in DNA repair genes and long-term survival in cisplatin-based neoadjuvant chemotherapy for muscle invasive bladder cancer (MIBC). (2019) (1)
- Shc proteins and brain functions: Possible implications for neuroprotection (2006) (1)
- RNA interference screening methods to identify proliferation determinants and mechanisms of resistance to immune attack. (2020) (1)
- Fibroblast activation protein and focal adhesion kinase: novel stromal therapeutic targets in pancreatic adenocarcinoma. (2004) (1)
- TACCing on new functions for the TSC2 tumor suppressor (2010) (1)
- Protein Interaction–Targeted Drug Discovery (2005) (1)
- The small molecule compound, MCP1, inhibits Ras-Raf interaction in mammalian cells and induces apoptosis in various hematopoietic cancer cells (2004) (1)
- 6 Yeast Hybrid Approaches (2007) (1)
- Aurora Kinases as Therapeutic Targets in Head and Neck Cancer. (2022) (1)
- Informatics-guided drug repurposing for Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2020) (1)
- RNA Interference Screening to Identify Proliferation Determinants in Breast Cancer Cells. (2017) (1)
- Abstract 1834: Constitutive Nedd9 null genotype promotes lung cancer aggressiveness (2017) (1)
- Analysis and manipulation of intracellular signaling cascades. (2004) (1)
- Abstract 1731: Preclinical testing demonstrates strong activity of STA-12-8666, an HSP90 inhibitor-SN-38 conjugate, in small cell lung cancer (SCLC) (2015) (1)
- A bacterial/yeast merged two-hybrid system: protocol for yeast screening with single or parallel baits. (2007) (0)
- bihíbrido system yeast / bacteria and methods for their use (2005) (0)
- Abstract 808: Functional evaluation of novel germline DNA repair variants identified in patients with early-onset renal cancer (2021) (0)
- Abstract LB-178: Genomic analysis identifies a subset of laryngeal tumors with poor prognosis (2015) (0)
- Aurora A kinase (AURKA) in normal and pathological cell division (2012) (0)
- Signatures of defective DNA repair and replication in early-onset renal cancer patients referred for germline genetic testing. (2022) (0)
- Abstract 276: Targeting signaling networks via RNAi to improve therapy for ovarian cancer (2012) (0)
- TITLE: Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer (2019) (0)
- Abstract 874: MSI2 regulates VEGFR2 signaling and tumor progression in NSCLC (2022) (0)
- ’ s response to reviews Title : An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion (2019) (0)
- Abstract 2937:Nedd9controls autophagy to limit non-small cell lung cancer (NSCLC) growth (2021) (0)
- novel branch of the thioredoxin fold superfamily The evolutionarily conserved Dim1 protein defines a (2015) (0)
- Abstract 338: Unexpected activity of multiple targeted cancer drugs in regulating ciliary dynamics (2017) (0)
- Abstract 4452: Musashi-2 regulates EGFR/HER3 expression in NSCLC, cell proliferation and response to EGFR inhibitors in EGFR-mutant NSCLC (2018) (0)
- Abstract 1242: Combination of p21-activated kinase 1 (PAK1) inhibitor FRAX1036 and Aurora-A inhibitor alisertib is effective in hormone receptor-positive breast cancer (2016) (0)
- Predictive Biomarkers and Personalized Medicine Quanti fi cation of Excision Repair Cross-Complementing Group 1 and Survival in p 16-Negative Squamous Cell Head and Neck Cancers (2013) (0)
- Award Number: W81XWH-06-1-0073 TITLE: Do Deregulated Cas Proteins Induce Genomic Instability in Early-Stage Ovarian Cancer (2006) (0)
- Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization (2015) (0)
- A combined yeast / bacterial two-hybrid system ( YBTH ) : development and evaluation (2009) (0)
- A NOVEL TRIBLOCK COPOLYMER HYDROGEL TALC FOAM DELIVERY SYSTEM TO TREAT MALIGNANT PLEURAL EFFUSIONS (2019) (0)
- Abstract 3257: NEDD9 is required for initiation of HER2/Neu-dependent mammary tumor development (2010) (0)
- The Biology behind Gene Expression: A Basic Tutorial (2004) (0)
- Abstract 2014: An estrogen receptor - centered network for probing anti-estrogen drug resistance with siRNA screening technology (2010) (0)
- Abstract 955: Musashi-2 regulates EGFR expression in NSCLC, cell proliferation and survival, response to EGFR inhibitors in EGFR-mutant NSCLC (2019) (0)
- Abstract 940: Loss of Pkd1 limits colorectal cancer by increasing colon barrier function (2022) (0)
- Emerging genomic landscape and therapeutic targets in young patients with colorectal cancer (CRC). (2016) (0)
- dominant negative human hDim1 (hDim1 1-128) (2003) (0)
- Abstract 1840:Nedd9controls glycolysis and autophagy in non-small cell lung cancer (NSCLC) (2019) (0)
- Clinical Trial Development in TP53-Mutated Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma. (2022) (0)
- Abstract 5286: A pipeline for developing a novel, predictive tool to classify variants of uncertain significance (VUS) in Lynch Syndrome (2016) (0)
- Mutation of the core or adjacent LVb elements of the Moloney murine leuk.e.ml.a virus enhancer alters disease speclhclty (2007) (0)
- Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing (2023) (0)
- Methodes de triage (1991) (0)
- Association of Aurora kinase A and epidermal growth factor receptor (EGFR) gene copy number with overall survival in KRAS wild-type patients with metastatic colorectal cancer. (2010) (0)
- Hsp90 inhibition slows cyst growth in a mouse model of Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2012) (0)
- Abstract 419: PKD1 regulates susceptibility to ulcerative colitis and colorectal cancer (2020) (0)
- Abstract C06: Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer (2019) (0)
- Enhancer of Filamentation 1 (2008) (0)
- Abstract 542: Synthetic lethal targeting of AURKA in head and neck squamous cell carcinoma (2023) (0)
- Abstract B106: Nedd9 null status initially delays mammary tumor growth, then selects for hyper‐aggressive mammary tumors (2009) (0)
- Faculty Opinions recommendation of Calibrated mitotic oscillator drives motile ciliogenesis. (2018) (0)
- Faculty Opinions recommendation of Persistent repair intermediates induce senescence. (2019) (0)
- Preclinical efficacy of STA-12-8666, an HSP90 inhibitor-targeted SN-38 conjugate, in small cell lung cancer (SCLC). (2015) (0)
- Abstract 4732: Analysis of KRAS variant in a cohort of resected HPV negative HNSCC (2017) (0)
- Abstract 1716: Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation (2015) (0)
- Abstract 349: Association of DNA damage response capacity with neoadjuvant chemoradiation response in locally advanced rectal cancer (2021) (0)
- Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry (2023) (0)
- Preclinical Testing Demonstrates Striking Efficacy of STA-12-8666, an Hsp90 Inhibitor–Targeted SN-38 Conjugate, in Small Cell Lung Cancer (2014) (0)
- 246 INVITED Targeting Her: Can resistance to EGFR inhibitors be overcome? (2008) (0)
- A retrospective evaluation of a decade of Gene Wiki Reviews and their impact. (2022) (0)
- Abstract 4743: Analysis of a protein expression biomarkers in HPV negative SCCHN (2014) (0)
- Abstract 4242: Effects of dual inhibition of EGFR and Aurora A kinase in a lung cancer model (2014) (0)
- Extended characterization of MCP110, an inhibitor of Ras-dependent signaling: Mode of action and preclinical analysis (2004) (0)
- Abstract 3459:PKD1regulates susceptibility to ulcerative colitis and colorectal cancer (2019) (0)
- Abstract 3878: Musashi-2 (MSI2) regulation of ERBB family proteins in non-small cell lung cancer (NSCLC) (2017) (0)
- ' s response to reviews Title : Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb 2 internalization (2015) (0)
- Ciliary signalling in cancer (2018) (0)
- Abstract B25: Anti-Mullerian hormone (AMH) supports epithelial identity and survival signaling in lung cancer (2016) (0)
- Prognostic significance of Musashi 2 (MSI2) RNA-binding protein expression in precancerous polyps and during colorectal cancer (CRC) progression. (2020) (0)
- Abstract 4739: Genetic predisposition to DNA double strand break repair defect defines a new class of familial colon cancer (2015) (0)
- Abstract 2178: Diet-modulated SCAP-SREBP signaling is essential for acinar cell differentiation, pancreatic morphogenesis, and pancreatic adiposity (2022) (0)
- small academic laboratories Encroaching genomics: adapting large-scale science to (2015) (0)
- Do Deregulated Cas Proteins Induce Genomic Instability In Early Stage Ovarian Cancer (2008) (0)
- H2-gamendazole (H2-GMZ): a new therapeutic lead for treatment of polycystic kidney4 disease. (2022) (0)
- Abstract P1-05-03: A requirement for neural precursor cell-expressed developmentally downregulated gene 9 during the initiation of mammary tumorigenesis in MMTV-neu mice (2012) (0)
- Genomic distinctions between colon and rectal cancer in young patients. (2016) (0)
- Abstract 1086: The role of HEF1 protein in stabilization and activation of AurA kinase in metastatic breast cancer (2010) (0)
- Targeting SRC Family Kinases and HSP90 in Lung Cancer (2015) (0)
- Abstract 5098: Targeting the cholesterol pathway geneSC4MOLsensitizes cancer to EGFR inhibitors (2010) (0)
- Abstract 4098: Musashi-2 (MSI2) activates TGF-β signaling and inhibits CLDN7 to promote non-small cell lung cancer (NSCLC) metastasis (2015) (0)
- Taking Snapshots of Ciliary Signaling. (2015) (0)
- Faculty Opinions recommendation of Academic research in the 21st century: maintaining scientific integrity in a climate of perverse incentives and hypercompetition. (2019) (0)
- NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis (2017) (0)
- An expanded classification of active, inactive, and druggable RAS conformations (2022) (0)
- Author response: Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence (2016) (0)
- Integrin-dependent Antagonism of Tamoxifen Therapy through Transcriptional Replacement: Establishing a Basis for a New Combined Therapy (2004) (0)
- Two-Hybrid Protein–Protein Interactions (2004) (0)
- Editor's evaluation: Concomitant activation of GLI1 and Notch1 contributes to racial disparity of human triple negative breast cancer progression (2021) (0)
- Methods | Two-Hybrid Protein–Protein Interactions (2021) (0)
- Corrections: Interactions Among Members of the Bcl-2 Protein Family Analyzed with a Yeast Two-Hybrid System (1995) (0)
- Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System. (2020) (0)
- Abstract 537: Information-driven approaches to predicting familial risk for prostate cancer (2015) (0)
- Abstract 3718: NSD histone methyltransferases drive cell proliferation in HPV-negative head and neck squamous cell carcinoma (HNSCC) (2022) (0)
- An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion (2019) (0)
- Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer (2020) (0)
- Abstract PL6-2: Antibody-initiated cancer immunotherapy (2010) (0)
- Aurora A kinase activity influences calcium signaling in kidney cells (2011) (0)
- Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry (2023) (0)
- Identification of evolutionarily conserved DNA damage response (DDR) genes that alter sensitivity to cisplatin (2016) (0)
- Abstract 5814: Synthetic lethal therapy to overcome resistance to AURKA inhibition in HPV-negative head and neck cancer (2018) (0)
- Abstract 34: AMH and AMHR2 regulate survival signaling, epithelial-mesenchymal transition (EMT) and resistance to HSP90 inhibition in non-small cell lung cancer (NSCLC) (2015) (0)
- Targeting the ErbB Family in Head and Neck Cancer (2018) (0)
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