Erik De Clercq

Q: What Schools Are Affiliated With Erik De Clercq

Erik De Clercq is affiliated with the following schools: King's College, Aberdeen, University of Alcalá, Ghent University, University of Antwerp, University of Hull, University of Iceland, University of Alberta, KU Leuven, Utrecht University, Stanford University, Cardiff University, University of Las Palmas de Gran Canaria, University of Zagreb

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Erik De Clercq

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Why Is Erik De Clercq Influential?

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According to Wikipedia, Erik De Clercq M.D. Ph.D., is a Belgian physician and biologist. He studied medicine at the Catholic University of Leuven . He did research and later became a professor at the Department of Medicine, where he specialised in microbiology and immunology. He worked at the Rega Institute for Medical Research. He is one of the founders and the second president of the International Society for Antiviral Research.

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Erik De Clercq's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. (1988) (1518)
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) (1455)
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity (2001) (981)
Approved Antiviral Drugs over the Past 50 Years (2016) (862)
Angiogenesis: regulators and clinical applications. (2001) (770)
Antiviral drugs in current clinical use. (2004) (757)
A novel selective broad-spectrum anti-DNA virus agent (1986) (732)
HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells* (2003) (706)
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives (1990) (669)
1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity. (1994) (657)
Acyclic nucleoside phosphonates: a key class of antiviral drugs (2005) (598)
Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4 (1997) (575)
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. (2009) (547)
Frontiers in Microbiology (1987) (546)
Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. (1980) (536)
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus (1988) (506)
LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells* (2003) (502)
Sulfated polysaccharides extracted from sea algae as potential antiviral drugs. (1997) (498)
Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. (1995) (482)
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (2000) (478)
Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy (2005) (475)
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. (1987) (469)
Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4 (2002) (465)
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. (1988) (439)
The bicyclam AMD3100 story (2003) (429)
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. (1979) (400)
Strategies in the design of antiviral drugs (2010) (383)
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. (1995) (371)
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. (1989) (356)
Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go? (2010) (355)
Antiviral agents active against influenza A viruses (2006) (335)
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine (1993) (329)
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. (1987) (323)
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. (1989) (318)
Antiviral agents active against influenza A viruses (2006) (315)
Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. (1987) (305)
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100 (1994) (298)
Synthesis and biological activity of 4-thiazolidinones, thiosemicarbazides derived from diflunisal hydrazide. (2006) (297)
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later (2008) (297)
New developments in anti-HIV chemotherapy (2001) (293)
Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives. (2007) (293)
Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy (2006) (291)
Macrophage Tropism of Human Immunodeficiency Virus Type 1 Isolates from Brain and Lymphoid Tissues Predicts Neurotropism Independent of Coreceptor Specificity (2001) (290)
Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis (2004) (283)
The design of drugs for HIV and HCV (2007) (279)
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. (1987) (275)
The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro (2006) (274)
AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-γ Receptor-Deficient Mice1 (2001) (271)
Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV (1998) (270)
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative. (1989) (269)
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine] (1998) (268)
The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase (2005) (261)
Antiviral drugs in current clinical use. (2004) (261)
Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. (2006) (251)
Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine. (1999) (251)
The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection (1998) (248)
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents (1988) (245)
The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. (1992) (239)
Activities of various compounds against murine and primate polyomaviruses (1997) (236)
Selective inhibitors of picornavirus replication (2008) (235)
Suramin: A potent inhibitor of the reverse transcriptase of RNA tumor viruses (1979) (234)
HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections (1997) (234)
Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends. (2016) (234)
Strategies in the design of antiviral drugs (2002) (233)
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. (1992) (232)
(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity (1978) (231)
Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one. (1999) (225)
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication (1988) (224)
Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro (1991) (224)
The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides. (1987) (223)
Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. (1997) (223)
Clinical features and treatment of adenovirus infections (2008) (222)
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS). (1986) (217)
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection (2000) (215)
Antivirals and antiviral strategies (2004) (212)
Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections (2003) (211)
Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted N-Alkylcarbamoyl and N,N-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO Analogues (1998) (211)
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. (1991) (210)
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite. (1996) (207)
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents. (2001) (207)
Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α (1998) (207)
Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)]. (1987) (205)
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection (2000) (201)
Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. (1990) (198)
HIV inhibitors targeted at the reverse transcriptase. (1992) (198)
Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). (1988) (196)
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues. (2001) (196)
New developments in anti-HIV chemotherapy (2001) (192)
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. (1989) (187)
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT. (1993) (187)
The AMD3100 story : The path to the discovery of a stem cell mobilizer (Mozobil) (2009) (187)
Current drug research on PEGylation with small molecular agents (2013) (186)
Perspectives for the treatment of infections with Flaviviridae. (2000) (184)
Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents. (2008) (184)
CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages (1998) (180)
Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. (1988) (179)
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones (2010) (179)
Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives. (2009) (178)
Antiviral and antimetabolic activities of neplanocins. (1985) (177)
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. (1991) (176)
Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. (2000) (176)
Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates. (2009) (176)
Expression of human fibroblast interferon gene in Escherichia coli (1980) (175)
Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin mannich bases. (2000) (175)
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species. (1988) (174)
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. (1999) (173)
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus. (1987) (173)
HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design (2013) (173)
The HIV‐1 Reverse Transcription (RT) Process as Target for RT Inhibitors (2000) (172)
Synthesis and antiviral activity of imidazo[1,2-a]pyridines (1999) (170)
Synthesis of new benzimidazole-coumarin conjugates as anti-hepatitis C virus agents. (2008) (168)
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection (2006) (168)
Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate. (1992) (167)
Differential signalling of the chemokine receptor CXCR4 by stromal cell‐derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes (2000) (165)
Synthesis of imidazo[1,2-a]pyridines as antiviral agents. (1998) (165)
S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents (1987) (164)
Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base. (1999) (164)
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors. (2005) (164)
Antiviral activity against human immunodeficiency virus type 1 (HIV‐1) and type 2 (HIV‐2) of ethnobotanically selected Ethiopian medicinal plants (2001) (163)
Cytotoxic activities of Mannich bases of chalcones and related compounds. (1998) (161)
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. (2001) (161)
Antivirals and antiviral strategies. (2004) (161)
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. (2000) (161)
CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. (1999) (160)
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. (2002) (160)
A novel approach for the virtual screening and rational design of anticancer compounds. (2000) (159)
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. (2000) (157)
Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro (1987) (156)
New approaches toward anti-HIV chemotherapy. (2005) (156)
In search of a selective antiviral chemotherapy. (1997) (154)
Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents. (2007) (153)
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents. (2002) (152)
A case of human Orf in an immunocompromised patient treated successfully with cidofovir cream (2001) (152)
Antiviral drug susceptibility of human herpesvirus 8 (1997) (151)
Determinants for Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100 (1998) (151)
Antiviral agents active against human herpesviruses HHV‐6, HHV‐7 and HHV‐8 (2001) (151)
HIV resistance to reverse transcriptase inhibitors (1994) (151)
Nucleoside Inhibitors of Zika Virus. (2016) (150)
Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). (1994) (149)
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid (2009) (148)
Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues (2005) (148)
Successful treatment of a squamous papilloma of the hypopharynx‐esophagus by local injections of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine (1995) (147)
In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells (2003) (147)
Mannose-Specific Plant Lectins from the Amaryllidaceae Family Qualify as Efficient Microbicides for Prevention of Human Immunodeficiency Virus Infection (2004) (147)
The history of antiretrovirals: key discoveries over the past 25 years. (2009) (147)
Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells. (1994) (147)
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. (1999) (146)
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. (1992) (146)
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. (1992) (143)
Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus. (1983) (143)
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. (1991) (141)
Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. (1996) (139)
New anti‐HIV agents and targets (2002) (139)
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase. (1993) (138)
Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction (2003) (136)
Therapeutic potential of HPMPC as an antiviral drug (1993) (134)
The design of drugs for HIV and HCV. (2007) (134)
The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo (1998) (133)
Molecular strategies to inhibit the replication of RNA viruses (2008) (133)
Viral Infection and Host Defense (1974) (133)
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication (1996) (133)
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents. (1996) (132)
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity. (1992) (131)
Role of CXCR4 in Cell-Cell Fusion and Infection of Monocyte-Derived Macrophages by Primary Human Immunodeficiency Virus Type 1 (HIV-1) Strains: Two Distinct Mechanisms of HIV-1 Dual Tropism (1999) (130)
Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonyloxymethyl)9-(2-Phosphonylmethoxypropyl)adenine in Mice (1998) (130)
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives. (1991) (130)
Chicoric acid analogues as HIV-1 integrase inhibitors. (1999) (130)
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. (2002) (130)
Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections (2003) (129)
Antiviral drugs: current state of the art. (2001) (129)
Recent developments in herpesvirus therapy. (2001) (128)
Thymidylate synthetase as target enzyme for the inhibitory activity of 5-substituted 2'-deoxyuridines on mouse leukemia L1210 cell growth. (1981) (128)
Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets. (1983) (128)
Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain. (1996) (128)
Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid. (2004) (127)
The regulation of HIV‐1 transcription: Molecular targets for chemotherapeutic intervention (2006) (127)
Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines (1991) (127)
Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection. (2001) (127)
Cidofovir in the treatment of poxvirus infections (2002) (127)
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1981) (127)
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine. (1986) (125)
Antiviral agents : characteristic activity spectrum depending on the molecular target with which they interact (1993) (125)
Current therapy for chronic hepatitis C: The role of direct-acting antivirals (2017) (124)
Antiviral therapy for human immunodeficiency virus infections. (1995) (124)
Exploring the active site of herpes simplex virus type‐1 thymidine kinase by X‐ray crystallography of complexes with aciclovir and other ligands (1998) (124)
Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins (1991) (124)
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export (2002) (123)
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins. (1981) (122)
Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections. (1995) (122)
Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds (1991) (122)
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides. (1993) (121)
A 40-Year Journey in Search of Selective Antiviral Chemotherapy* (2011) (121)
Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity (2007) (121)
Heterocyclic rimantadine analogues with antiviral activity. (2003) (120)
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine]. (1983) (120)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future. (2004) (120)
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine. (1990) (119)
Biological evaluation of proanthocyanidin dimers and related polyphenols. (1999) (118)
Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry. (1996) (118)
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. (1993) (117)
Antiviral drugs: current state of the art. (2001) (117)
Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis. (1987) (117)
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties. (2003) (117)
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). (1998) (116)
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. (2005) (116)
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections (2019) (116)
Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents. (2010) (115)
Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. (1995) (115)
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis. (1987) (115)
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents. (2007) (115)
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system. (1998) (114)
Shift of Clinical Human Immunodeficiency Virus Type 1 Isolates from X4 to R5 and Prevention of Emergence of the Syncytium-Inducing Phenotype by Blockade of CXCR4 (1999) (114)
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. (1988) (114)
T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use (1998) (113)
Potential antivirals and antiviral strategies against SARS coronavirus infections (2006) (113)
Cidofovir in the treatment of poxvirus infections (2002) (113)
Antiviral agents acting as DNA or RNA chain terminators. (2009) (112)
Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives (1989) (112)
Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine in severe herpes zoster. (1980) (112)
Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives. (1996) (112)
HIV-1-specific RT inhibitors : highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase (1993) (112)
Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones. (1999) (111)
Anti-Human Immunodeficiency Virus Drug Combination Strategies (1998) (111)
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. (1993) (111)
Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta. (1982) (110)
Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538) (1996) (110)
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo (1989) (110)
Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide (1969) (110)
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms. (2012) (110)
Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses (1994) (110)
Novel sulfated polymers as highly potent and selective inhibitors of human immunodeficiency virus replication and giant cell formation (1990) (109)
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV. (1999) (109)
Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives. (2004) (109)
Increased susceptibility of cells treated with interferon to the toxicity of polyriboinosinic-polyribocytidylic acid. (1972) (109)
Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine. (1999) (109)
Antivirals: past, present and future. (2013) (109)
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters. (2000) (109)
New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture (2002) (108)
Diverging binding capacities of natural LD78β isoforms of macrophage inflammatory protein‐1α to the CC chemokine receptors 1, 3 and 5 affect their anti‐HIV‐1 activity and chemotactic potencies for neutrophils and eosinophils (2001) (107)
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor. (1989) (107)
Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections. (1996) (107)
Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo. (1999) (107)
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro. (1968) (107)
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection (1999) (107)
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus. (2011) (106)
Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent (2008) (106)
Antiviral drug discovery and development: where chemistry meets with biomedicine. (2005) (106)
Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action. (1996) (106)
3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosides. (1992) (106)
Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues (2000) (105)
Highlights in the discovery of antiviral drugs: a personal retrospective. (2010) (105)
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. (2001) (105)
Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers. (2010) (105)
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. (2005) (104)
Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. (1998) (104)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future. (2004) (104)
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro (1994) (104)
The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil). (2009) (103)
The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine. (1999) (103)
Efficacy of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice (1993) (103)
Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy (1993) (102)
Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG). (1990) (102)
A time-of–drug addition approach to target identification of antiviral compounds (2011) (102)
Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents. (2007) (101)
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice. (1986) (101)
Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and its Derivatives with Triazole (2000) (101)
Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides (1969) (100)
Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production (1996) (100)
The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. (1998) (100)
Antiviral Portrait Series: 4. Polysuifates as Inhibitors of HIV and Other Enveloped Viruses (1994) (100)
Sulfated Polysaccharides as Potent Inhibitors of HIV‐Induced Syncytium Formation: A New Strategy Towards AIDS Chemotherapy (1990) (99)
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T). (1992) (99)
DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration (2000) (99)
Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test. (1996) (99)
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity. (2008) (98)
Emerging anti-HIV drugs. (2005) (98)
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides. (1995) (97)
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins (2004) (97)
The effects of cidofovir 1% with and without cyclosporin a 1% as a topical treatment of acute adenoviral keratoconjunctivitis: a controlled clinical pilot study. (2002) (97)
Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor. (1999) (97)
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. (1995) (97)
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures. (2002) (97)
Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine. (1983) (96)
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture (1994) (96)
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles. (2016) (95)
Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses (2018) (95)
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond. (2011) (95)
Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III) (2000) (95)
Treatment of anogenital papillomavirus infections with an acyclic nucleoside phosphonate analogue. (1995) (95)
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents. (2008) (94)
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity. (2003) (93)
Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T‐cell lymphotropic virus (HTLV‐III)/lymphadenopathy‐associated virus (LAV) (1986) (93)
Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. (2001) (93)
Molecular approaches for the treatment of hemorrhagic fever virus infections. (1993) (93)
Antiviral activity spectrum and target of action of different classes of nucleoside analogues (1994) (92)
Biochemical aspects of the selective antiherpes activity of nucleoside analogues (1984) (92)
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus. (1991) (92)
Preclinical studies on thiocarboxanilide UC‐781 as a virucidal agent (1998) (92)
Multiple dideoxynucleoside analogue‐resistant (MddNR) HIV‐1 strains isolated from patients from different European countries (1998) (92)
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. (2010) (92)
Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines. (1998) (91)
Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs. (1984) (91)
Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro. (1990) (91)
Antivaccinia Activities of Acyclic Nucleoside Phosphonate Derivatives in Epithelial Cells and Organotypic Cultures (2002) (91)
Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A (2005) (91)
Quantitative analysis of human herpesvirus 6 cell tropism (2005) (91)
The acyclic nucleoside phosphonates from inception to clinical use: historical perspective. (2007) (90)
Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II. (2007) (90)
In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds (1982) (89)
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase (2006) (89)
Flow cytometric method to demonstrate whether anti-HIV-1 agents inhibit virion binding to T4+ cells. (1989) (89)
Vaccinia Virus Inhibitors as a Paradigm for the Chemotherapy of Poxvirus Infections (2001) (89)
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication. (1991) (89)
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. (1991) (89)
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems. (1996) (89)
Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design. (1992) (88)
Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations. (1999) (88)
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. (2004) (88)
cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system. (1999) (88)
Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds. (1999) (88)
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4. (1999) (87)
Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds. (1988) (87)
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists. (2006) (87)
The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling. (1999) (87)
Phase I/II study of intravitreal cidofovir for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. (1995) (87)
Recent advances in DAPYs and related analogues as HIV-1 NNRTIs. (2011) (87)
Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis (1991) (87)
SYNTHESIS AND ANTI-HIV ACTIVITY OF NEW MODIFIED 1,2,3-TRIAZOLE ACYCLONUCLEOSIDES (2001) (87)
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency. (2005) (86)
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF) (2016) (86)
Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations (2003) (85)
5′-Nor Carbocyclic 5′-Deoxy-5′-(Isobutylthio)Adenosine and a 2′,3′-Dideoxy-2′,3′-Didehydro Derivative (2001) (85)
Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2. (1996) (85)
The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication (2006) (85)
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents. (1992) (84)
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections (2004) (84)
3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues. (1989) (84)
Design strategies of novel NNRTIs to overcome drug resistance. (2009) (84)
New anti-HIV agents and targets. (2002) (84)
Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1). (1996) (84)
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. (2007) (84)
Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein. (1997) (84)
C-Nucleosides To Be Revisited. (2016) (83)
Drug targets in cytomegalovirus infection. (2009) (83)
Antiviral activity of aliphatic nucleoside analogues: structure-function relationship. (1979) (83)
5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase. (1982) (83)
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones. (2003) (82)
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry. (2000) (82)
Anti-Hiv-1 Activity of 2′,3′-Dideoxinucleoside Analogues : Structure-Activity Relationship (1989) (82)
Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography. (2002) (81)
Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents. (1993) (81)
Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles. (2002) (81)
Design of Anti-AIDS Drugs (1990) (81)
Vaccinia Virus Inhibitors as a Paradigm for the Chemotherapy of Poxvirus Infections (2001) (81)
Antiviral enantiomeric preference for 5'-noraristeromycin. (1994) (81)
Design and synthesis of bioactive adamantane spiro heterocycles. (2007) (80)
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine (1996) (80)
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice (1991) (80)
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action. (2005) (80)
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. (2004) (80)
Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist (2004) (80)
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. (1991) (80)
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360 (2004) (79)
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. (1994) (79)
Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1. (1997) (79)
Anti‐influenza virus agents: Synthesis and mode of action (2006) (79)
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides. (1983) (79)
Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: a controlled clinical pilot study. (2001) (79)
Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus. (1986) (79)
Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives (1999) (79)
Broad-spectrum antiviral activity of adenosine analogues. (1984) (79)
Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites (2005) (78)
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides. (1992) (78)
Selective inhibition of hepatitis B virus replication by RNA interference. (2003) (78)
Novel compounds in preclinical/early clinical development for the treatment of HIV infections. (2000) (78)
Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. (2000) (78)
CADA, a novel CD4-targeted HIV inhibitor, is synergistic with various anti-HIV drugs in vitro (2004) (78)
Viral Entry through CXCR4 Is a Pathogenic Factor and Therapeutic Target in Human Immunodeficiency Virus Type 1 Disease (2000) (78)
Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses (1990) (78)
The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship. (1999) (77)
Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro (1988) (77)
Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication (1999) (77)
Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation. (1989) (77)
Anti-HIV activity of dextran sulphate as determined under different experimental conditions. (1989) (77)
Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes. (2009) (77)
Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells. (1981) (77)
Evolution of anti-HIV drug candidates. Part 1: From α-Anilinophenylacetamide (α-APA) to imidoyl thiourea (ITU) (2001) (76)
Development of vaginal microbicides for the prevention of heterosexual transmission of HIV. (1996) (76)
Recent highlights in the development of new antiviral drugs. (2005) (76)
Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation (2005) (76)
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines. (1985) (75)
Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423. (2004) (75)
Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro (1999) (75)
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis. (1993) (74)
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. (2006) (74)
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches. (2015) (74)
Recent highlights in the development of new antiviral drugs (2005) (74)
Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies. (2009) (74)
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. (1999) (74)
Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic Furano Pyrimidine Nucleosides (2005) (74)
Cellular uptake of phosphonylmethoxyalkylpurine derivatives. (1991) (74)
Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure (2004) (74)
New acquisitions in the development of anti-HIV agents. (1989) (74)
Synthesis and Antiviral Properties of Arabino and Ribonucleosides of 1,3‐Dideazaadenine, 4‐Nitro‐1, 3‐dideazaadenine and Diketopiperazine (2004) (73)
CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity. (1998) (73)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV-1) infections: strategies to overcome drug resistance development. (1996) (73)
In vitro susceptibility of feline herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine. (1989) (73)
Synthesis, Characterization and in Vitro Study of the Cytostatic and Antiviral Activity of New Polymeric Silver(I) Complexes with Ribbon Structures Derived from the Conjugated Heterocyclic Thioamide 2-Mercapto-3,4,5,6-tetra- hydropyrimidine (2004) (73)
The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C (2008) (73)
Mutations in the Nonstructural Protein 3A Confer Resistance to the Novel Enterovirus Replication Inhibitor TTP-8307 (2009) (73)
Human Fibroblast Interferon for Clinical Trials: Pharmacokinetics and Tolerability in Experimental Animals and Humans (1979) (73)
Benzylidene-bis-(4-Hydroxycoumarin) and Benzopyrano-Coumarin Derivatives: Synthesis, 1H/13C-NMR Conformational and X-ray Crystal Structure Studies and In Vitro Antiviral Activity Evaluations (2011) (72)
Cidofovir Resistance in Vaccinia Virus Is Linked to Diminished Virulencein Mice (2006) (72)
1H-13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein. (2000) (72)
Clinical significance of chemokine receptor antagonists (2020) (72)
Overview of Recent Strategic Advances in Medicinal Chemistry. (2019) (72)
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. (2017) (72)
Activity of the Anti-Orthopoxvirus Compound ST-246 against Vaccinia, Cowpox and Camelpox Viruses in Cell Monolayers and Organotypic Raft Cultures (2007) (71)
Current concepts of interferon and interferon induction. (1970) (71)
Current race in the development of DAAs (direct-acting antivirals) against HCV. (2014) (71)
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents. (2004) (71)
Inhibitory effect of (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP on clinical ocular adenoviral isolates is serotype-dependent in vitro. (1991) (71)
Antitumor potential of acyclic nucleoside phosphonates. (1999) (71)
Comparative activities of several nucleoside analogs against duck hepatitis B virus in vitro (1990) (71)
CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor. (2002) (71)
ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES (2005) (70)
Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future (2008) (70)
Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds. (2007) (70)
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity. (2007) (70)
Detection of HIV-1 RNA in plasma and serum samples using the NASBA amplification system compared to RNA-PCR. (1995) (70)
Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities. (2002) (70)
Polyacetal Carboxylic Acids: a New Group of Antiviral Polyanions (1970) (70)
The relationship between incorporation of E-5-(2-Bromovinyl)-2'-deoxyuridine into herpes simplex virus type 1 DNA with virus infectivity and DNA integrity. (1983) (69)
Antiviral activity of 5-ethyl pyrimidine deoxynucleosides. (1975) (69)
HIV inhibitors targeted at the reverse transcriptase. (1992) (69)
Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro. (1991) (69)
Trends in the development of new antiviral agents for the chemotherapy of infections caused by herpesviruses and retroviruses (1995) (69)
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. (2019) (69)
Synthesis and antiviral activity evaluation of some aminoadamantane derivatives. (1994) (69)
Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro (1987) (69)
Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders. (2004) (69)
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. (2000) (69)
Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). (1991) (69)
Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase. (2000) (69)
Potential antivirals and antiviral strategies against SARS coronavirus infections (2006) (69)
Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators. (2006) (68)
Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models. (1999) (68)
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents. (2006) (68)
Novel sulfated polysaccharides: dissociation of anti-human immunodeficiency virus activity from antithrombin activity. (1990) (68)
Evaluation of SDF‐1/CXCR4‐induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry (2003) (68)
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives. (2009) (68)
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives. (1991) (67)
2001 ASPET Otto Krayer Award Lecture. Molecular targets for antiviral agents. (2001) (67)
Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient. (2005) (67)
Correlation between the antiviral activity of acyclic and carbocyclic adenosine analogues in murine L929 cells and their inhibitory effect on L929 cells S-adenosylhomocysteine hydrolase. (1989) (67)
Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis (2005) (67)
Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice (2003) (67)
Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]-Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections (2007) (67)
Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention (2007) (67)
Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid. (2000) (66)
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. (2009) (66)
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus. (1993) (66)
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. (1996) (66)
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine. (1987) (66)
Antiviral activity of C-5 substituted tubercidin analogues. (1984) (66)
Efficacy of Cidofovir in a Murine Model of Disseminated Progressive Vaccinia (2004) (66)
Chemical studies of essential oils of Juniperus oxycedrus ssp. badia. (2002) (66)
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives. (2002) (66)
Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum. (2005) (65)
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin. (2006) (65)
The discovery of antiviral agents: ten different compounds, ten different stories. (2008) (65)
New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents. (1992) (65)
Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation (2010) (65)
Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro (1987) (65)
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains. (2007) (65)
Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins. (1991) (65)
Synthesis, Antibacterial, Antifungal And Anti-HIV Activity Of Schiff And Mannich Bases Of Isatin With N-[6-Chlorobenzothiazol-2-yl] Thiosemicarbazide (1999) (65)
Antiproliferative and apoptotic effects of iron chelators on human cervical carcinoma cells. (2002) (65)
High‐level expression of active HIV‐1 integrase from a synthetic gene in human cells (2000) (65)
Efficacy of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine and 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice (1992) (65)
Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture (2005) (65)
Nucleoside analogues : chemistry, biology, and medical applications (1979) (65)
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections (1989) (65)
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. (2007) (65)
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase. (1995) (65)
HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches. (2004) (64)
Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase. (1985) (64)
Presence of class II histocompatibility DR proteins on the envelope of human immunodeficiency virus demonstrated by FACS analysis. (1992) (64)
Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain. (1998) (64)
Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene. (2000) (64)
Synthesis, Antibacterial, Antifungal, and Anti-HIV Evaluation of Norfloxacin Mannich Bases. (2010) (64)
Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates (2002) (64)
Meningoradiculoneuritis due to acyclovir‐resistant varicella zoster virus in an acquired immune deficiency syndrome patient (1994) (64)
ANN-QSAR model for selection of anticancer leads from structurally heterogeneous series of compounds. (2007) (64)
The acyclic nucleoside phosphonates from inception to clinical use: historical perspective. (2007) (64)
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis (1980) (64)
Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109. (1996) (64)
Anterior nongranulomatous uveitis after intravitreal HPMPC (cidofovir) for the treatment of cytomegalovirus retinitis. Analysis and prevention. (1997) (64)
The CXCR4 Antagonist AMD3100 Efficiently Inhibits Cell-Surface-Expressed Human Immunodeficiency Virus Type 1 Envelope-Induced Apoptosis (2000) (64)
Synthesis and antiviral activity of 3-substituted imidazo[1,2-a]pyridines. (1994) (64)
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds. (2004) (63)
Comparative efficacy of antiherpes drugs in different cell lines. (1982) (63)
Nucleoside Inhibitors of Tick-Borne Encephalitis Virus (2015) (63)
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA. (2001) (63)
Potential use of antiviral agents in polio eradication. (2008) (63)
Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells (2003) (63)
Suramin in the treatment of AIDS: mechanism of action. (1987) (63)
Carbocyclic Adenosine Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Antiviral Agents: Recent Advances (1998) (63)
High efficiency latency and activation of herpes simplex virus in human cells. (1982) (63)
cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade. (1999) (63)
Oral brivudin vs. intravenous acyclovir in the treatment of herpes zoster in immunocompromised patients: A randomized double‐blind trial (1995) (63)
Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. (1993) (62)
Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells. (2016) (62)
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors. (2008) (62)
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro. (1987) (62)
HIV Genome-Wide Protein Associations: a Review of 30 Years of Research (2016) (62)
The antiviral agent cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine] has pronounced activity against nasopharyngeal carcinoma grown in nude mice. (1998) (62)
The Interferon Inducer Ampligen [Poly(I)-Poly(C12U)] Markedly Protects Mice against Coxsackie B3 Virus-Induced Myocarditis (2004) (62)
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses. (2017) (62)
Antivirals for the treatment of herpesvirus infections (1993) (62)
Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro. (1999) (62)
In search of a selective antiviral chemotherapy (1997) (61)
7‐Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase (1998) (61)
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity. (1987) (61)
Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors. (1992) (61)
Specific targets for antiviral drugs (1982) (61)
A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5Δ32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4 (2002) (60)
Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies (2012) (60)
Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: establishment of structure-activity relationships. (2001) (60)
Emerging anti-HIV drugs (2005) (60)
ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS (2001) (60)
The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor. (2003) (60)
Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogues of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin. (1987) (60)
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides. (2005) (60)
Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine treatment of severe herpes zoster in cancer patients. (1984) (60)
Novel inhibitors of human CMV. (2008) (59)
Antiviral drug discovery: ten more compounds, and ten more stories (part B). (2009) (59)
Effect of Interferon, Polyacrylic Acid, and Polymethacrylic Acid on Tail Lesions in Mice Infected with Vaccinia Virus (1968) (59)
Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2′-C-Methylcytidine, the Active Component of Valopicitabine (2006) (59)
Nucleotide Delivery from cycloSaligenyl‐3′‐azido‐3′‐deoxythymidine Monophosphates (cycloSal‐AZTMP) (1998) (59)
"Viologen" dendrimers as antiviral agents: the effect of charge number and distance. (2010) (59)
Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds. (2007) (59)
Anti‐HIV Activity of Thiosemicarbazone and Semicarbazone Derivatives of (±)‐3‐Menthone (2002) (59)
Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells. (1990) (59)
Application of a gastric cancer cell line (MKN-28) for anti-adenovirus screening using the MTT method. (1996) (59)
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs (1994) (59)
Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) (2020) (59)
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones. (2003) (59)
Targets and strategies for the antiviral chemotherapy of AIDS (1990) (58)
Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment of maintenance of latent herpes simplex virus infection in mice. (1981) (58)
Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR. (1999) (58)
Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV‐2 in mice: Impact on the search for vaginal microbicides (2000) (58)
Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity. (1993) (58)
Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents. (1985) (58)
Antivirals for the treatment of herpesvirus infections. (1993) (58)
Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation. (1997) (58)
Acyclic Nucleoside Phosphonates in the Chemotherapy of DNA Virus and Retrovirus Infections (1997) (58)
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives. (1991) (58)
In Vitro and In Vivo Inhibition of Murine Gamma Herpesvirus 68 Replication by Selected Antiviral Agents (1998) (58)
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action. (2000) (58)
Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity. (1996) (58)
Ebola virus (EBOV) infection: Therapeutic strategies. (2015) (58)
Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus. (1988) (58)
Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections† (2010) (57)
Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics (2006) (57)
Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. herpes-, papova-, pox- and adenovirus) infections. (1996) (57)
Therapeutic potential of Cidofovir (HPMPC, Vistide) for the treatment of DNA virus (i.e. herpes-, papova-, pox- and adenovirus) infections (1996) (57)
Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives (2012) (57)
Antiviral Activity of Triazine Analogues of 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) and Related Compounds (2007) (56)
Local administration of cidofovir for human papilloma virus associated skin lesions in transplant recipients (2007) (56)
Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase (1991) (56)
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. (2018) (56)
The nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors in the treatment of HIV infections (AIDS). (2013) (56)
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (2009) (56)
Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors. (2002) (56)
Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) for the treatment of human immunodeficiency virus type 1 (HIV‐1) infections: Strategies to overcome drug resistance development (1996) (56)
Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. (2014) (56)
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro. (1991) (55)
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide. (2009) (55)
Cyclic saligenyl phosphotriesters of 2′,3′-dideoxy-2′,3′-didehydrothymidine (d4T) — a new pro-nucleotide approach (1997) (55)
Incorporation of E-5-(2-halovinyl)-2'-deoxyuridines into deoxyribonucleic acids of herpes simplex virus type 1-infected cells. (1982) (55)
Purification of interferon by adsorption chromatography on controlled pore glass. (1976) (55)
Antiviral drug discovery and development: where chemistry meets with biomedicine. (2005) (55)
New approaches toward anti-HIV chemotherapy. (2005) (55)
Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles (2009) (55)
Species-dependent and site-specific intestinal metabolism of ester prodrugs. (2000) (55)
Inhibition of human and woodchuck hepatitis virus DNA polymerase by the triphosphates of acyclovir, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and E-5-(2-bromovinyl)-2'-deoxyuridine. (1984) (55)
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors. (2012) (55)
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells. (2008) (55)
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector. (2002) (55)
Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2', 3'-dideoxyguanosine in vitro. (1987) (55)
Inhibition of HIV infection by CXCR4 and CCR5 chemokine receptor antagonists. (2001) (55)
Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines. (1998) (55)
Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: a brief history of stavudine (D4T) and its comparison with other dideoxynucleosides. (2010) (54)
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. (2019) (54)
Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells (1996) (54)
The LD78β Isoform of MIP-1α Is the Most Potent CC-Chemokine in Inhibiting CCR5-Dependent Human Immunodeficiency Virus Type 1 Replication in Human Macrophages (2001) (54)
STRUCTURAL REQUIREMENTS FOR SYNTHETIC POLYANIONS TO ACT AS INTERFERON INDUCERS * (1970) (54)
Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity. (2006) (54)
Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324. (1996) (54)
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection. (1999) (54)
Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs. (2000) (54)
Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus (1997) (54)
Specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral DNA. (1987) (53)
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. (1996) (53)
Evaluation of two commercial kits for the detection of genotypic drug resistance on a panel of HIV type 1 subtypes A through J. (2001) (53)
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones. (2009) (53)
Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir (2003) (53)
Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues. (1986) (53)
Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells. (1994) (53)
Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines. (1997) (53)
Stability-Activity Relationships of a Family of G-tetrad Forming Oligonucleotides as Potent HIV Inhibitors (2000) (53)
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams. (1996) (53)
Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes. (1991) (53)
Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo. (1984) (53)
Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors. (2000) (53)
Adverse events and autopsy findings after intravitreous cidofovir (HPMPC) therapy in patients with acquired immune deficiency syndrome (AIDS). (1997) (53)
Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro. (1989) (52)
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles. (2019) (52)
Comparative inhibitory effects of various nucleoside and nonnucleoside analogues on replication of influenza virus types A and B in vitro and in ovo. (1993) (52)
Inhibition of angiogenesis by blockers of volume-regulated anion channels. (2000) (52)
AIDS dementia: Synthesis and properties of a derivative of 3′‐azido‐3′‐deoxythymidine (AZT) that may become ‘locked’ in the central nervous system (1988) (52)
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines. (2015) (52)
Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts. (2006) (52)
Antiviral Activity of low-MW Dextran Sulphate (Derived from dextran MW 1000) Compared to Dextran Sulphate Samples of Higher MW (1991) (52)
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP. (2000) (52)
HIV resistance to reverse transcriptase inhibitors. (1994) (52)
Hypoglycemic, anticomplement and anti-HIV activities of Spathodea campanulata stem bark. (1999) (52)
5-Nitro-2'-deoxyuridine and 5-nitro-2'-deoxyuridine 5'-monophosphate: antiviral activity and inhibition of thymidylate synthetase in vivo. (1978) (52)
Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua. (2006) (52)
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT. (2005) (52)
Synthesis and Studies of New 2‐(Coumarin‐4‐yloxy)‐4,6‐(substituted)‐s‐Triazine Derivatives as Potential Anti‐HIV Agents (2009) (51)
Novel 3-(2-adamantyl)pyrrolidines with potent activity against influenza A virus-identification of aminoadamantane derivatives bearing two pharmacophoric amine groups. (2001) (51)
Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds. (1991) (51)
Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues. (2007) (51)
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation. (2002) (51)
Comparative activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against rat cytomegalovirus infection in vitro and in vivo (1991) (51)
Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine). (1999) (51)
Synthesis and antiviral activity of novel N-substituted derivatives of acyclovir. (1988) (51)
Intranasal challenge of mice with herpes simplex virus: an experimental model for evaluation of the efficacy of antiviral drugs. (1976) (51)
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues. (1993) (51)
John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity. (2005) (51)
Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. (2002) (51)
Novel inhibitors of HIV-1 integration. (2004) (51)
Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years (2019) (51)
A new topical treatment for resistant herpes simplex infections. (1993) (51)
Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics. (2003) (50)
Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. (1997) (50)
Targets for the Design of Antiviral Agents (1984) (50)
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. (1986) (50)
Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus. (2013) (50)
Bis-DEAE-fluorenone: mechanism of antiviral protection and stimulation of interferon production in the mouse. (1971) (50)
Zinc(II) complexes of constrained antiviral macrocycles. (2012) (50)
Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro. (1997) (50)
Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus (1996) (50)
Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases. (1991) (50)
Phosphorylation of aciclovir, ganciclovir, penciclovir and S2242 by the cytomegalovirus UL97 protein: a quantitative analysis using recombinant vaccinia viruses. (1997) (50)
Effect of Cytosine Arabinoside, lododeoxyuridine, Ethyldeoxyuridine, Thiocyanatodeoxyuridine, and Ribavirin on Tail Lesion Formation in Mice Infected with Vaccinia Virus (1976) (50)
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. (2007) (50)
Cidofovir in the treatment of HPV-associated lesions. (2001) (50)
Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin (2005) (50)
Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism. (2004) (50)
Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration. (2019) (49)
Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation. (2005) (49)
Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication (1998) (49)
Anti-HIV agents: design and discovery of new potent RT inhibitors. (2003) (49)
Enzymatic activities induced by interferon in human fibroblast cell lines differing in their sensitivity to the anticellular activity of interferon. (1981) (49)
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation. (2009) (49)
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants. (1994) (49)
Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration (2019) (49)
Evaluation of Hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)Propyl]- Adenine, CMX157, as a Potential Treatment for Human Immunodeficiency Virus Type 1 and Hepatitis B Virus Infections (2007) (49)
What can be Expected from Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) in the Treatment of Human Immunodeficiency Virus Type 1 (HIV-1) Infections? (1996) (49)
Antiviral activity of 5-substituted pyrimidine nucleoside analogues (1983) (48)
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. (1994) (48)
Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment (2019) (48)
Assays for the evaluation of HIV-1 integrase inhibitors. (2001) (48)
Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry. (2007) (48)
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication (1991) (48)
Synthesis and antiviral activity of stereoisomeric eritadenines (1982) (48)
Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact. (1993) (48)
Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine. (2004) (48)
Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12 (1998) (48)
Activity of recombinant HIV-1 integrase on mini-HIV DNA. (1999) (48)
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication. (2010) (48)
Towards an Effective Chemotherapy of Virus Infections: Therapeutic Potential of Cidofovir [( S )-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine, HPMPC] for the Treatment of DNA Virus Infections (1998) (48)
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors. (1996) (48)
Selective activity of various antiviral compounds against HHV-7 infection. (1999) (48)
Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus. (2002) (47)
The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells. (1998) (47)
Transport, Uptake, and Metabolism of the Bis(pivaloyloxymethyl)-Ester Prodrug of 9-(2- Phosphonylmethoxyethyl)Adenine in an In Vitro Cell Culture System of the Intestinal Mucosa (Caco-2) (1997) (47)
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach. (2014) (47)
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission. (1998) (47)
Sulfanyltriazole/tetrazoles: a promising class of HIV-1 NNRTIs. (2009) (47)
5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase. (1998) (47)
Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus. (2016) (47)
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures. (2011) (47)
Synthesis and anti-HIV activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives. (2001) (47)
Prevalence of Genotypic Resistance among Antiretroviral Drug-Naive HIV-1-Infected Patients in Belgium (2001) (47)
Prevalence and origin of HIV-1 group M subtypes among patients attending a Belgian hospital in 1999. (2002) (47)
Anti‐retrovirus activity of 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered (1990) (47)
Activities of Several Classes of Acyclic Nucleoside Phosphonates against Camelpox Virus Replication in Different Cell Culture Models (2007) (47)
Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100. (2005) (47)
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists (2004) (47)
Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives (2005) (47)
In search of a selective therapy of viral infections (2010) (46)
Synthesis and Biological Activity of Novel 1H,3H-Thiazolo[3,4-a]Benzimidazoles: Non-nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors (1999) (46)
Substituted imidazopyridines as potent inhibitors of HCV replication☆ (2009) (46)
Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones. (2001) (46)
Charge modification of plasma and milk proteins results in antiviral active compounds (1999) (46)
Highlights in the development of new antiviral agents. (2002) (46)
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector. (2002) (46)
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors. (1999) (46)
Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives (2002) (46)
Comparative activity of selected antiviral compounds against clinical isolates of varicella-zoster virus (1995) (46)
Thermal activation of the antiviral activity of synthetic double-stranded polyribonucleotides. (1971) (46)
Mycophenolate mofetil strongly potentiates the anti-herpesvirus activity of acyclovir. (1998) (46)
Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir. (2002) (46)
Palladium(II) complexes of dialkyl alpha-Anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity. (1996) (46)
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth‐inhibitory properties of (E)‐5‐(2‐bromovinyl)‐2'‐deoxyuridine and related compounds (1985) (46)
New synthesis and anti-HIV and antiviral properties of 3-arylsulfonyl derivatives of 4-ydroxycoumarin and 4-hydroxyquinolone (2008) (46)
Heparin-Mimicking Sulfonic Acid Polymers as Multitarget Inhibitors of Human Immunodeficiency Virus Type 1 Tat and gp120 Proteins (2007) (46)
Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors. (1995) (46)
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles. (2007) (46)
Tumor necrosis factor enhances replication of human immunodeficiency virus (HIV) in vitro. (1989) (46)
Moloney Sarcoma Virus-Induced Tumors in Mice: Inhibition or Stimulation by (Poly rI)·(Poly rC) 1 (1971) (46)
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition. (1994) (46)
5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells. (2007) (45)
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations. (2007) (45)
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations. (2007) (45)
Highly potent and selective inhibition of varicella‐zoster virus replication by bicyclic furo[2,3‐d]pyrimidine nucleoside analogues (2003) (45)
Differential Intracellular Compartmentalization of Herpetic Thymidine Kinases (TKs) in TK Gene-Transfected Tumor Cells: Molecular Characterization of the Nuclear Localization Signal of Herpes Simplex Virus Type 1 TK (1998) (45)
Varicella-zoster virus in the human corneal endothelium: a case report. (1980) (45)
The Nucleoside Derivative 5′-O-Trityl-inosine (KIN59) Suppresses Thymidine Phosphorylase-triggered Angiogenesis via a Noncompetitive Mechanism of Action* (2004) (45)
Inhibiting effects of cidofovir (HPMPC) on the growth of the human cervical carcinoma (SiHa) xenografts in athymic nude mice. (1998) (45)
S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents. (1987) (45)
Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir. (2001) (45)
Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir. (1991) (45)
Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro. (1988) (45)
[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1 (1992) (45)
Organotypic Epithelial Raft Cultures as a Model for Evaluating Compounds against Alphaherpesviruses (2005) (45)
Evaluation of antiviral activity against human herpesvirus 8 (HHV-8) and Epstein-Barr virus (EBV) by a quantitative real-time PCR assay. (2004) (45)
HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches. (2004) (45)
Analysis of the herpes simplex virus genome during in vitro latency in human diploid fibroblasts and rat sensory neurons (1984) (45)
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases. (1989) (44)
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents. (2009) (44)
Antihiv, antibacterial and antifungal activities of some novel 1,4-disubstituted-1,2,4-triazolo[4,3-a] quinazolin-5(4H)-ones (2006) (44)
Intraocular pressure and aqueous humor dynamics in patients with AIDS treated with intravitreal cidofovir (HPMPC) for cytomegalovirus retinitis. (1997) (44)
Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity (2009) (44)
Increase in Antiviral Activity of Polynucleotides by Thermal Activation (1970) (44)
Potent inhibition of hemangioma formation in rats by the acyclic nucleoside phosphonate analogue cidofovir. (1998) (44)
Tenofovir alafenamide (TAF) as the successor of tenofovir disoproxil fumarate (TDF). (2016) (44)
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. (2007) (44)
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives. (2003) (44)
SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques. (1997) (44)
Anti-HIV Activity Of Some Mannich Bases Of Isatin Derivatives (1998) (44)
DNA Polymerase Mutations in Drug-Resistant Herpes Simplex Virus Mutants Determine In Vivo Neurovirulence and Drug-Enzyme Interactions (2007) (44)
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds. (2006) (44)
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (2009) (44)
Antiviral Drug Development (1988) (44)
Potential clinical applications of the CXCR4 antagonist bicyclam AMD3100 (2005) (44)
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. (2006) (43)
Enhancement of transplantation‐associated atherosclerosis by CMV, which can be prevented by antiviral therapy in the form of HPMPC (1994) (43)
Acyclic nucleoside phosphonates: a new dimension to the chemotherapy of DNA virus and retrovirus infections. (1998) (43)
Recent Advances in the Search for Selective Antiviral Agents (1989) (43)
The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication (1994) (43)
A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470. (1999) (43)
HIV‐1‐specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase (1993) (43)
Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid. (1988) (43)
Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. (1968) (43)
(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection (1995) (43)
The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication (2007) (43)
Cidofovir in the therapy and short-term prophylaxis of poxvirus infections (2002) (43)
Synthetic interferon inducers. (1974) (43)
New antivirals - mechanism of action and resistance development. (1998) (43)
Managing resistance to anti-HIV drugs: an important consideration for effective disease management. (1999) (43)
Local and systemic protection by synthetic polyanionic interferon inducers in mice against intranasal, vesicular stomatitis virus. (1969) (43)
Effect of 5-Iodo-2′-Deoxyuridine on Vaccinia Virus (Orthopoxvirus) Infections in Mice (2002) (43)
Anti-HIV activity of N-1-adamantyl-4-aminophthalimide. (1997) (43)
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine. (1982) (43)
Syncytium formation and destruction of bystander CD4+ cells cocultured with T cells persistently infected with human immunodeficiency virus as demonstrated by flow cytometry. (1989) (43)
Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles. (2012) (43)
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues. (1984) (43)
RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE) (1997) (43)
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. (2003) (42)
Specificity of interferon-induced enhancement of toxicity for double-stranded ribonucleic acids. (1973) (42)
Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives (2014) (42)
Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). (1995) (42)
Intrathecal administration of interferon in neonatal herpes. (1975) (42)
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice (1979) (42)
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues. (2003) (42)
Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities (2005) (42)
Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. (2000) (42)
Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds. (2002) (42)
A Cutting‐Edge View on the Current State of Antiviral Drug Development (2013) (42)
Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation. (1999) (42)
Role of cidofovir in the treatment of DNA virus infections, other than CMV infections, in immunocompromised patients. (2002) (42)
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections. (2003) (42)
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors. (2008) (42)
Comparison of the LiPA HIV-1 RT test, selective PCR and direct solid phase sequencing for the detection of HIV-1 drug resistance mutations. (1998) (42)
Are the 2-Isomers of the Drug Rimantadine Active Anti-Influenza a Agents? (2003) (41)
Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy (2001) (41)
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine. (1989) (41)
5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents. (1989) (41)
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus (1997) (41)
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis. (1992) (41)
Efficacy of 2-Amino-7-(1,3-Dihydroxy-2-Propoxymethyl)Purine for Treatment of Vaccinia Virus (Orthopoxvirus) Infections in Mice (2001) (41)
The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice. (1970) (41)
Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity. (2009) (41)
In vitro and in vivo inhibition of ortho- and paramyxovirus infections by a new class of sulfonic acid polymers interacting with virus-cell binding and/or fusion (1994) (41)
Antiviral and antimetabolic activities of neplanocins (1985) (41)
Milestones in the discovery of antiviral agents: nucleosides and nucleotides (2012) (41)
Mechanism of inhibition of adenovirus DNA replication by the acyclic nucleoside triphosphate analogue (S)-HPMPApp: influence of the adenovirus DNA binding protein. (1989) (41)
Synthesis and antiviral activity of novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazepines (2006) (41)
Synthesis of mono-, bis-spiro- and dispiro-β-lactams and evaluation of their antimalarial activities (2011) (41)
Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. (1988) (40)
Selective antiherpes agents (1982) (40)
Selective Activity of Various Nucleoside and Nucleotide Analogues against Human Herpesvirus 6 and 7 (1997) (40)
Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: Report of a case (1998) (40)
env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors (2002) (40)
Collinone, a new recombinant angular polyketide antibiotic made by an engineered Streptomyces strain. (2001) (40)
Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication. (1993) (40)
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors. (2000) (40)
Synthesis and Anti-HIV Activity of some Novel Chain-Extended Phosphoramidate Derivatives of d4T (Stavudine): Esterase Hydrolysis as a Rapid Predictive Test for Antiviral Potency (1998) (40)
Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin. (2005) (40)
Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines. (1991) (40)
Synthesis and antiviral activity of 6-benzyl analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. (2010) (40)
Fidelity analysis of HIV-1 reverse transcriptase mutants with an altered amino-acid sequence at residues Leu74, Glu89, Tyr115, Tyr183 and Met184. (2000) (40)
2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections. (2002) (40)
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. (1997) (40)
Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides. (1990) (40)
Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain. (2002) (39)
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. (2012) (39)
AMD3100/CXCR4 Inhibitor (2015) (39)
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. (1994) (39)
Pretreatment with Topical 0.1% (S)-1 -(3-hydroxy-2-phosphonylmethoxypropyl)cytosine Inhibits Adenovirus Type 5 Replication in the New Zealand Rabbit Ocular Model (1992) (39)
Treatment of herpes simplex virus infections (1999) (39)
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study (2020) (39)
Adefovir dipivoxil. Commentaries (1999) (39)
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs. (2007) (39)
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs. (2013) (39)
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase. (1995) (39)
Structure modifications of 6-aminoquinolones with potent anti-HIV activity. (2004) (39)
Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene. (1987) (39)
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series. (2004) (39)
Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors. (1980) (39)
The antiviral spectrum of (E)-5-(2-bromovinyl)-2 ′-deoxyuridine (1984) (39)
Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines. (1991) (39)
Oral bromovinyldeoxyuridine therapy for herpes simplex and varicella‐zoster virus infections in severely immunosuppressed patients: A preliminary clinical trial (1986) (39)
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720 (1994) (39)
Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors (2004) (39)
Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives. (2006) (39)
Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study. (2001) (39)
Quantitative evaluation of HIV-1 coreceptor use in the GHOST3 cell assay. (2001) (39)
Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication. (1991) (39)
Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine (1990) (38)
Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides). (1997) (38)
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. (2007) (38)
The Acyclic Nucleoside Phosphonates (ANPs): Antonín Holý's Legacy (2013) (38)
Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism. (2000) (38)
3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties. (1995) (38)
Synthesis, Anti-Human Immunodeficiency Virus Activity and Esterase Lability of Some Novel Carboxylic Ester-Modified Phosphoramidate Derivatives of Stavudine (d4T) (1998) (38)
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives. (1992) (38)
Mechanism of anti-HIV activity of negatively charged albumins: biomolecular interaction with the HIV-1 envelope protein gp120. (1996) (38)
Efficacy of bromovinyldeoxyuridine in the treatment of herpes simplex virus and varicella-zoster virus eye infections. (1984) (38)
Activities of Acyclic Nucleoside Phosphonates against Orf Virus in Human and Ovine Cell Monolayers and Organotypic Ovine Raft Cultures (2005) (38)
From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors. (2005) (38)
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil. (2000) (38)
Use of Cotton Rats to Evaluate the Efficacy of Antivirals in Treatment of Measles Virus Infections (2000) (38)
Spectroscopic and biological properties of palladium(II) complexes of ethyl 2-quinolylmethylphosphonate. (1998) (38)
3,5‐Bis(benzylidene)‐4‐oxo‐1‐phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi‐Drug‐Resistance Reverting Properties (2009) (38)
A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781. (1998) (38)
Basic approaches to anti-retroviral treatment. (1991) (38)
Resolution of aristeromycin enantiomers. (1985) (38)
Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies (2004) (38)
Phosphonylmethoxyalkylpurines and -pyrimidines as inhibitors of African swine fever virus replication in vitro. (1987) (38)
Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines. (2002) (38)
The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis. (1997) (38)
1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity (1998) (38)
Organic Chemist Whose Inventions Reshaped the Antiviral Drug World (2013) (38)
ADA-Bypass by lipophilic cycloSal-ddAMP pro-nucleotides A second example of the efficiency of the cycloSal-Concept (1997) (38)
New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A. (1996) (38)
Synthesis and Anti-HIV-1 Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors (2007) (38)
The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides. (2001) (37)
C-Nucleosides To Be Revisited. (2016) (37)
Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine. (1992) (37)
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain. (1992) (37)
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives. (2007) (37)
Poly(Hydroxy)Carboxylates as Selective Inhibitors of Cytomegalovirus and Herpes Simplex Virus Replication (1992) (37)
Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine). (1998) (37)
Highlights in Antiviral Drug Research: Antivirals at the Horizon (2012) (37)
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs (2008) (37)
Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine. (1982) (37)
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. (1984) (37)
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties. (1999) (37)
Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside. (1990) (37)
Local treatment of HPV‐induced skin lesions by Cidofovir (2002) (37)
DNA-induced Polymerization of HIV-1 Integrase Analyzed with Fluorescence Fluctuation Spectroscopy* (2002) (37)
ENHANCED INHIBITION OF HIV-1 REPLICATION IN MACROPHAGES BY ANTISENSE OLIGONUCLEOTIDES, RIBOZYMES AND ACYCLIC NUCLEOSIDE PHOSPHONATE ANALOGS DELIVERED IN pH-SENSITIVE LIPOSOMES (2001) (37)
Synthesis and antiviral activities of 8-alkynyl-, 8-alkenyl-, and 8-alkyl-2'-deoxyadenosine analogues. (1994) (37)
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity. (1990) (37)
Selective Anti-Herpesvirus Agents (2013) (37)
The Holý Trinity (2013) (37)
In search of effective anti-HHV-6 agents. (2006) (37)
Recovery of Cell-Bound Interferon (1972) (37)
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations. (2005) (37)
Synthesis and antiviral activity of some new 1H-1,2,4-triazole derivatives (1994) (36)
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138. (2001) (36)
Quantitative structural activity relationship study of bis-tetraazacyclic compounds. A novel series of HIV-1 and HIV-2 inhibitors. (1995) (36)
Three decades of antiviral drugs (2007) (36)
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs. (2012) (36)
Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides (2012) (36)
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity. (1994) (36)
Mutational Analysis of Tyr-318 within the Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket of Human Immunodeficiency Virus Type I Reverse Transcriptase* (1998) (36)
ADA, a potential anti-HIV drug. (1996) (36)
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses. (2021) (36)
Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures (2006) (36)
Antiviral drug development : a multidisciplinary approach (1988) (36)
Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays. (2014) (36)
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. (2000) (36)
Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. (2018) (36)
Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro. (1990) (36)
An animal model for cidofovir (HPMPC) toxicity: intraocular pressure and histopathologic effects. (1997) (36)
Antiviral, antimetabolic and antineoplastic activities of 2'- or 3'-amino or -azido-substituted deoxyribonucleosides. (1980) (36)
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335 (1992) (36)
Coreceptor Phenotype of Natural Human Immunodeficiency Virus with Nef Deleted Evolves In Vivo, Leading to Increased Virulence (2002) (36)
Selective anti-herpesvirus agents. (2013) (36)
Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs (2019) (36)
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine. (1995) (36)
Human Immunodeficiency Virus Gene Regulation as a Target for Antiviral Chemotherapy (1999) (36)
Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes. (1992) (36)
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (2010) (36)
Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. (2004) (36)
Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides (2012) (36)
Design, Synthesis, and SAR of Naphthyl‐Substituted Diarylpyrimidines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase (2009) (35)
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations. (2007) (35)
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models. (1991) (35)
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections (2003) (35)
Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains (1995) (35)
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties. (2008) (35)
Cytotoxic 1,3-diarylidene-2-tetralones and related compounds. (2002) (35)
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages. (1992) (35)
Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. (1988) (35)
Mechanism of Antiviral Drug Resistance of Vaccinia Virus: Identification of Residues in the Viral DNA Polymerase Conferring Differential Resistance to Antipoxvirus Drugs (2008) (35)
Mutations at the CXCR4 interaction sites for AMD3100 influence anti‐CXCR4 antibody binding and HIV‐1 entry (2003) (35)
Sulphated Cyclodextrins are Potent anti-HIV Agents Acting Synergistically with 2′,3′-dideoxynucleoside Analogues (1991) (35)
The bicyclam AMD3100 story (2003) (35)
Dancing with chemical formulae of antivirals: A panoramic view (Part 2). (2013) (35)
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication. (1998) (35)
Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir. (2000) (35)
Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytes. (1992) (35)
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells. (1990) (35)
New perspectives for the treatment of HIV infections (1998) (35)
Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections (2005) (35)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) (1994) (35)
Furano Pyrimidines as Novel Potent and Selective Anti-VZV Agents (2001) (34)
Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era. (2012) (34)
Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines. (1992) (34)
Synthesis and Anti-Myxovirus Activity of Some Novel N,N′-Disubstituted Thioureas. (1994) (34)
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain. (2000) (34)
The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation. (2005) (34)
Anti‐angiogenic activity of a novel multi‐substrate analogue inhibitor of thymidine phosphorylase (2002) (34)
Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442) (1995) (34)
Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure (2008) (34)
Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II. (1993) (34)
Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization. (2014) (34)
Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds. (1989) (34)
Long-acting therapy of viral retinitis with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine. (1994) (34)
Human cytomegalovirus increases constitutive production of interleukin-6 and leukemia inhibitory factor by bone marrow stromal cells. (1996) (34)
Synergism in the antitumor effects of type 1 and type II interferon in mice inoculated with leukemia L1210 cells. (1982) (34)
Design and synthesis of bioactive 1,2-annulated adamantane derivatives. (2008) (34)
Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity (1996) (34)
Antiviral and antimetabolic activities of formycin and its N1-, N2-, 2'-O- and 3'-O-methylated derivatives. (1975) (33)
TSG101: a novel anti-HIV-1 drug target. (2010) (33)
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. (2003) (33)
Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles (2000) (33)
Induction of interferon by nonviral agents. (1970) (33)
Human herpesvirus 6 infection arrests cord blood mononuclear cells in G2 phase of the cell cycle (2004) (33)
Perspectives for the treatment of hepatitis B virus infections. (1999) (33)
Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus (1985) (33)
Comparative Study of Various Double-stranded RNAs as Inducers of Human Interferon (1977) (33)
5-Propyl-2'-deoxyuridine: a specific anti-herpes agent (1978) (33)
Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1. (1996) (33)
Antirhinovirus activity of purine nucleoside analogs (1986) (33)
Inhibitors of infectious pancreatic necrosis virus (IPNV) replication. (1996) (33)
Stabilisation of interferons by defensive reversible denaturation (1974) (33)
Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase (2000) (33)
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations. (2009) (33)
From adefovir to Atripla™ via tenofovir, Viread™ and Truvada™ (2006) (33)
Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a Lichrospher 60 RP-8 HPLC column. (1989) (33)
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine. (1984) (33)
Interferon induction by synthetic polynucleotides: importance of purine N-7 and strandwise rearrangement. (1974) (33)
Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues. (1994) (33)
Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors. (1995) (33)
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. (2005) (33)
Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect. (1993) (33)
An active interferon inducer obtained from Hemophilus influenzae type B. (1969) (33)
Disciplinary Approach to Understanding Cytomegalovirus Disease (1993) (33)
Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir. (2002) (33)
New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1. (1996) (33)
Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in HB611 Cells (1994) (32)
Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin. (1989) (32)
Halogenated sesquiterpenes from the red alga Laurencia obtusa (2002) (32)
Antiviral activity of polyribocytidylic acid in cells primed with polyriboinosinic acid. (1971) (32)
Non-antiviral activities of interferon are not controlled by chromosome 21 (1975) (32)
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase. (2002) (32)
Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists. (2007) (32)
Synergistic antiviral effects of antiherpes compounds and human leukocyte interferon on varicella-zoster virus in vitro (1984) (32)
New inhibitors of human cytomegalovirus (HCMV) on the horizon (2003) (32)
Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogues that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase. (1992) (32)
Recent progress in the research of small molecule HIV-1 RNase H inhibitors. (2014) (32)
Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1. (1998) (32)
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo. (1991) (32)
Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines. (1982) (32)
Reduced Fitness of HIV-1 Resistant to Cxcr4 Antagonists (2003) (32)
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. (2020) (32)
Synthesis, Antibacterial And AntiHIV Activities Of 3-(5-Amino-6-(2-3-Dichloro-Phenyl)-(1,2,4) Triazin-3-Yl)-6,8-Dibromo-2-Substituted-3H-Quinozolin-4-One (2005) (32)
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? (2004) (32)
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. (1991) (32)
Antiviral Activity of Cyclosaligenyl Prodrugs of Acyclovir, Carbovir and Abacavir (2001) (32)
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy. (2010) (32)
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists. (2010) (32)
Cidofovir in the therapy and short-term prophylaxis of poxvirus infections (2002) (32)
In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine (1995) (31)
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents. (2003) (31)
Liposome-encapsulated (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for long-acting therapy of viral retinitis. (1996) (31)
The synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine-related compounds (1987) (31)
In Search of Authentic Inhibitors of HIV-1 Integration (2002) (31)
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine (1989) (31)
CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles. (2012) (31)
Synthesis of novel PETT analogues: 3,4-dimethoxy phenyl ethyl 1,3,5-triazinyl thiourea derivatives and their antibacterial and anti-HIV studies (2007) (31)
QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices. (2005) (31)
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine. (1981) (31)
Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine. (1990) (31)
(E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) (2005) (31)
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines. (1990) (31)
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives. (2012) (31)
Lack of retinal toxicity of the anticytomegalovirus drug (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine. (1992) (31)
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A. (2007) (31)
HIV-1 integration as a target for antiretroviral therapy: a review. (2001) (31)
Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides. (1995) (31)
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats. (1999) (31)
Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1H,3H-Thiazolo[3,4-a]Benzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor (1997) (31)
Translation of mouse interferon mRNA in Xenopus laevis oocytes and in rabbit reticulocyte lysates. (1978) (31)
Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication. (1998) (31)
Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains (2007) (31)
Pharmacokinetics of E-5-(2-Bromovinyl)-2′-Deoxyuridine in Mice (1979) (30)
Structure-activity studies on open-chain analogues of nucleosides: Inhibition of S-adenosyl-L-homocysteine hydrolase and antiviral activity 1. Neutral open-chain analogues (1985) (30)
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1. (1984) (30)
Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors. (1994) (30)
Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice (2003) (30)
(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine in the therapy of thymidine kinase-positive and -deficient herpes simplex virus experimental keratitis. (1991) (30)
New selective antiviral agents active against the AIDS virus (1987) (30)
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors. (2010) (30)
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues. (2008) (30)
Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives (2009) (30)
Potent antitumor activity of the acyclic nucleoside phosphonate 9‐(2‐phosphonylmethoxyethyl)adenine in choriocarcinoma‐bearing rats (1998) (30)
Effect of polyanionic compounds on intracutaneous and intravaginal herpesvirus infection in mice: impact on the search for vaginal microbicides with anti-HIV activity. (1995) (30)
Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin. (1986) (30)
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (2009) (30)
Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides: The search for linked π-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase (1997) (30)
Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses. (2006) (30)
5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine. (1989) (30)
Anti-HIV activity profile of AMD070, an orally bioavailable CXCR4 antagonist (2003) (30)
Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors (2011) (30)
Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds (1997) (30)
Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases. (2009) (30)
Systemic cidofovir in papillomatosis. (2001) (30)
Inhibition of the growth of Plasmodium falciparum and Plasmodium berghei by the DNA polymerase inhibitor HPMPA. (1991) (30)
Structural requirements of polynucleotides for the activation of (2' - 5')An polymerase and protein kinase. (1981) (30)
Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection. (1992) (30)
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis. (2002) (30)
Highlights in antiviral drug research: antivirals at the horizon. (2013) (30)
Structure-Based Bioisosterism Yields HIV 1 NNRTIs with Improved Drug Resistance Profiles and Favorable Pharmacokinetic Properties. (2020) (30)
Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity. (2005) (30)
AntiHIV, antibacterial and antifungal activities of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones (2007) (30)
Medicinal Chemistry: Synthesis and Pharmacochemical Investigation of Some Novel 1, 2, 4‐4H‐triazoles with Potential Antiviral Activity (1998) (30)
An epimer of 5'-noraristeromycin and its antiviral properties. (1994) (29)
Dancing with chemical formulae of antivirals: A personal account (2013) (29)
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line. (1998) (29)
Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine. (1989) (29)
Recent advances in antiviral activity of benzo/heterothiadiazine dioxide derivatives. (2008) (29)
Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry. (1989) (29)
Inhibitory effect of E-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on herpes simplex virus replication and DNA synthesis (1982) (29)
Potential drugs for the treatment of AIDS (1989) (29)
Fifty Years in Search of Selective Antiviral Drugs. (2019) (29)
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. (2007) (29)
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. (1991) (29)
Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines. (2010) (29)
2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action. (2014) (29)
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.). (2003) (29)
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. (1992) (29)
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins. (2007) (29)
Cytotoxic evaluation of some 3,5-diarylidene-4-piperidones and various related quaternary ammonium compounds and analogs. (1994) (29)
Potent inhibition of hemangiosarcoma development in mice by cidofovir (2001) (29)
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles. (2002) (29)
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond. (2011) (29)
Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents (2013) (29)
Emerging antiviral drugs (2008) (29)
Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains. (1995) (29)
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity. (2014) (29)
Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine. (1982) (29)
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice (1982) (28)
Acute Encephalitis, a Poliomyelitis‐like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections (2003) (28)
Bone marrow transplantation in a child with Wiskott‐Aldrich syndrome latently infected with acyclovir‐resistant (ACVr) herpes simplex virus type 1: Emergence of foscarnet‐resistant virus originating from the ACVr virus (2002) (28)
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation. (2001) (28)
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors. (2011) (28)
TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides. (1993) (28)
New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase. (1996) (28)
Human viral diseases: what is next for antiviral drug discovery? (2012) (28)
Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design. (2009) (28)
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site. (2018) (28)
Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents. (2016) (28)
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice (1997) (28)
Antivirals: current state of the art (2008) (28)
Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine. (1998) (28)
Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives. (1997) (28)
Synthesis, In Vitro and In Vivo Release Kinetics, and Anti‐HIV Activity of A Sustained‐Release Prodrug (mPEG‐AZT) of 3′‐Azido‐3′‐deoxythymidine (AZT, Zidovudine) (2010) (28)
Synthesis and QSAR studies on thiazolidinones as anti-HIV agents. (2005) (28)
Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs (1993) (28)
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro. (1987) (27)
Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues (1991) (27)
Review article Perspectives for the treatment of hepatitis B virus infections (1999) (27)
Frontiers in microbiology : from antibiotics to AIDS (1987) (27)
Intravitreal Cidofovir (HPMPC) Treatment of Cytomegalovirus Retinitis in Patients with Acquired Immune Deficiency Syndrome (1995) (27)
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice (2019) (27)
Long-term therapy for herpes retinitis in an animal model with high-concentrated liposome-encapsulated HPMPC. (1995) (27)
Antiretroviral drugs. (2010) (27)
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket. (2016) (27)
S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation. (1997) (27)
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells (1984) (27)
Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine. (1996) (27)
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA. (1999) (27)
Rodent models for the study of therapy against flavivirus infections. (2004) (27)
Highlights in the discovery of antiviral drugs: a personal retrospective. (2010) (27)
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. (2006) (27)
NF-kappaB: the inducible factors of HIV-1 transcription and their inhibitors. (2009) (27)
A potent interferon inducer derived from poly (7-deazainosinic acid). (1974) (27)
Exchanging the Yellow Fever Virus Envelope Proteins with Modoc Virus prM and E Proteins Results in a Chimeric Virus That Is Neuroinvasive in SCID Mice (2004) (27)
Comparative metabolism of E-5-(2-bromovinyl)-2'-deoxyuridine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells. (1987) (27)
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. (2008) (27)
Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives (1990) (27)
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers. (2001) (27)
Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice (1993) (27)
Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates. (1999) (27)
A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells. (1988) (27)
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors. (2004) (27)
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one. (1990) (27)
Differential Activity of Polyanionic Compounds and Castanospermine against HIV Replication and HIV-Induced Syncytium Formation Depending on Virus Strain and Cell Type (1992) (27)
Lead Optimization of Diarylpyrimidines as Non‐nucleoside Inhibitors of HIV‐1 Reverse Transcriptase (2010) (27)
Synthetic pyrimidine nucleoside analogues (1985) (27)
Degradation of Poly(inosinic acid) · poly(cytidylic acid) [(I)n· (Cn)] by Human Plasma (1979) (26)
Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles. (2019) (26)
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. (2020) (26)
Knocking out human immunodeficiency virus through non-nucleoside reverse transcriptase inhibitors used as single agents or in combinations: a paradigm for the cure of AIDS? (1995) (26)
Multivalent agents: a novel concept and preliminary practice in Anti-HIV drug discovery. (2013) (26)
Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus A activity relationship study using a combination of NMR spectroscopy and molecular modeling. (1999) (26)
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice. Increased therapeutic index and correlation with increased plasma 5-fluorouracil levels. (1988) (26)
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV. (2010) (26)
Oxime and dithiolane derivatives of 5-formyl-2'-deoxyuridine and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. (1980) (26)
The Antiherpesvirus Activity of H2G [(R)-9-[4-Hydroxy-2-(Hydroxymethyl)Butyl]Guanine] Is Markedly Enhanced by the Novel Immunosuppressive Agent Mycophenolate Mofetil (1998) (26)
Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding. (2006) (26)
Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase (1991) (26)
Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP. (2017) (26)
Highlights in the development of new antiviral agents. (2002) (26)
Replication of not-known-vector flaviviruses in mosquito cells is restricted by intracellular host factors rather than by the viral envelope proteins. (2010) (26)
Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compounds (1995) (26)
Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. (2002) (26)
Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication. (2011) (26)
Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach. (2014) (26)
Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives (2003) (26)
Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors. (2014) (26)
(S)‐9‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)adenine [(S)‐HPMPA]: a purine analogue with trypanocidal activity in vitro and in vivo (1996) (26)
Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives (2007) (26)
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives. (2006) (26)
Synthesis of adamantane spiro sultones as potential antiviral agents (1992) (26)
Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011). (2012) (26)
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. (2006) (26)
Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine. (1990) (26)
Infections with flaviviridae. (1999) (26)
Antiviral activity of polynucleotides: Role of the 2′‐hydroxyl and a pyrimidine 5‐methyl (1972) (26)
Nucleic acid related compounds. 53. Synthesis and biological evaluation of 2′-deoxy-β-threo-pentofuranosyl nucleosides. "Reversion to starting alcohol" in Barton-type reductions of thionocarbonates (1988) (26)
Analysis of inhibition of retroviral reverse transcriptase. (1996) (26)
Inducers and induction of interferons (1977) (26)
Isoxazolidine analogs of nucleosides (1992) (26)
A quantitative GFP-based bioassay for the detection of HIV-1 Tat transactivation inhibitors. (2001) (26)
Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective. (2009) (25)
Pyridine oxide derivatives: structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture (2002) (25)
Antiviral, antimetabolic, and cytotoxic activities of 5-substituted 2'-deoxycytidines. (1982) (25)
Synthesis and antiviral activity of three pyrazole analogues of distamycin A. (1994) (25)
Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors. (2004) (25)
Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors (2007) (25)
Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781. (2002) (25)
Comparative efficacy of antiherpes drugs in different cell lines (1982) (25)
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery. (2018) (25)
Viral DNA Polymerase Inhibitors (2009) (25)
(+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties. (1992) (25)
Fifty Years in Search of Selective Antiviral Drugs (2019) (25)
Anti-herpes activity of deoxythymidine analogues: specific dependence on virus-induced deoxythymidine kinase. (1977) (25)
Functional roles of azoles motif in anti-HIV agents. (2011) (25)
SYNTHESIS AND ANTIVIRAL ACTIVITY OF ACYCLIC ANALOGUES OF 1,5-ANHYDROHEXITOL NUCLEOSIDES USING MITSUNOBU REACTION (1996) (25)
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase. (2009) (25)
Activity of the keggin polyoxotungstate pm‐19 against herpes simplex virus type 2 infection in immunosuppressed mice: Role of peritoneal macrophage activation (1993) (25)
Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2'- and 5'-positions of the sugar moiety. (1995) (25)
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs. (2011) (25)
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase. (1992) (25)
Carbocyclic adenosine analogues as S-adenosylhomocysteine hydrolase inhibitors and antiviral agents: recent advances. (1998) (25)
6‐[2‐Phosphonomethoxy)Alkoxy]‐2,4‐Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity (2004) (25)
Nucleoside and nucleotide reverse transcriptase inhibitors (2001) (25)
Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds. (2004) (25)
Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus. (2019) (25)
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase. (2018) (25)
Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chain. (1994) (25)
Poly(rI) more important than poly(rC) in the interferon induction process by poly(rI)-poly(rC). (1973) (25)
A cutting-edge view on the current state of antiviral drug development. (2013) (25)
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. (2005) (25)
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization. (2017) (25)
Antiviral activity of 5-methylthiomethyl-2'-deoxyuridine and other 5-substituted 2'-deoxyuridines. (1979) (25)
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of rotavirus replication in vitro. (1986) (25)
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase. (1985) (25)
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity. (2007) (25)
Inhibitory effects of 9‐(2‐Phosphonylmethoxyethyl)adenine and 3′‐azido‐2′,3′‐dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus (1990) (25)
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. (2011) (25)
Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins (2011) (25)
Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS). (1986) (24)
Systematic synthesis and biological evaluation of alpha- and beta-D-lyxofuranosyl nucleosides of the five naturally occurring nucleic acid bases. (1987) (24)
Pyrimidine Nucleoside Analogues as Antiviral Agents (1984) (24)
Dual infection with polyomavirus BK and acyclovir‐resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient (2007) (24)
Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors (2019) (24)
Clinical characteristics of older and younger patients infected with SARS-CoV-2 (2020) (24)
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif. (2015) (24)
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (2011) (24)
Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine. (2000) (24)
Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir. (2004) (24)
6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains. (2004) (24)
Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine)and IDU (5-iodo-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits (1979) (24)
Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis. (1987) (24)
Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase. (1989) (24)
Studies on the antiviral activity and cell interaction of synthetic double-stranded polyribo- and polydeoxyribonucleotides. (1972) (24)
Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives. (2000) (24)
Enantioselective synthesis of homocarbocyclic-2′-oxo-3′-azanucleosides (2006) (24)
Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides. (2005) (24)
Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines (2009) (24)
Preliminary results of oral BVDU treatment of herpes zoster ophthalmicus. (1981) (24)
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents. (2007) (24)
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance. (2009) (24)
Sulphated and Sulphonated Polymers Inhibit the Initial Interaction of Hepatitis B Virus with Hepatocytes (2002) (24)
Antivirals: past, present and future. (2013) (24)
Synthesis, conformational characteristics and anti-influenza virus A activity of some 2-adamantylsubstituted azacycles. (2006) (24)
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. (2007) (24)
Synthesis and antiviral activity of 5'-deoxypyrazofurin. (1993) (24)
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors. (2012) (24)
Synthesis, Structure and in Vitro Anti-Human Immunodeficiency virus Activity of Novel 3-Methyl-1H,3H-Thiazolo[3,4-a]Benzimidazoles (1998) (24)
Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines (1996) (23)
Antiviral metal complexes. (1997) (23)
Interferon Production Linked to Toxicity of Polyriboinosinic Acid-Polyribocytidylic Acid (1972) (23)
Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness (2017) (23)
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase. (1999) (23)
Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus (1991) (23)
Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120 (1997) (23)
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. (2009) (23)
Antireverse transcriptase activity of gliotoxin analogs. (1978) (23)
Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position. (2005) (23)
Chiral synthesis of 4-[1-(2-deoxy-beta-L-ribofuranosyl)] derivatives of 2-substituted 5-fluoroaniline: "cytosine replacement" analogues of deoxy-beta-L-cytidine. (2000) (23)
Diaryl phosphate derivatives act as pro-drugs of AZT with reduced cytotoxicity compared to the parent nucleoside (1994) (23)
S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin (1993) (23)
Suramin in the treatment of AIDS: mechanism of action. (1987) (23)
Dipeptide Derivatives of AZT: Synthesis, Chemical Stability, Activation in Human Plasma, hPEPT1 Affinity, and Antiviral Activity (2008) (23)
Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene. (1985) (23)
Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives. (1995) (23)
1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes (1991) (23)
Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity. (1988) (23)
The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication. (1987) (23)
3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins. (2011) (23)
Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. (2011) (23)
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region (1999) (23)
Hiv-1 Specific Reverse Transcriptase Inhibitors: why are Tsao-Nucleosides so Unique? (2000) (23)
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation (2010) (23)
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. (2001) (23)
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. (1998) (23)
Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues. (2009) (23)
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside (1993) (23)
Discovery of small molecular inhibitors targeting HIV-1 gp120-CD4 interaction drived from BMS-378806. (2014) (23)
Synthesis, 18F‐Radiolabelling and Biological Evaluations of C‐6 Alkylated Pyrimidine Nucleoside Analogues (2004) (23)
Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro (1991) (23)
Interferon induction by a 2'-modified double-helical RNA, poly(2'-azido-2'-deoxyinosinic acid) . polycytidylic acid. (1978) (23)
3′-C-Trifluoromethyl Ribonucleosides (1995) (23)
Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells. (1984) (23)
In vitro Activity of a Novel Series of Polyoxosilicotungstates against Human Myxo-, Herpes- and Retroviruses (1993) (23)
Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections. (2017) (23)
A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities. (2015) (22)
Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance. (2004) (22)
Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. (1992) (22)
2‐(2,6‐Dihalo‐phenyl)‐3‐heteroaryl‐2‐ylmethyl‐1, 3‐thiazolidin‐4‐ones: Anti‐HIV agents (2008) (22)
Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5delta32) and normal human lymphoid tissue. (2001) (22)
Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides. (1999) (22)
Activities of Masked 2′,3′-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages (2000) (22)
Prospects for antiviral therapy. (2003) (22)
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. (1998) (22)
Polysulfonates Derived from Metal Thiolate Complexes as Inhibitors of HIV-1 and Various other Enveloped Viruses In Vitro (2002) (22)
COMPARATIVE STUDY OF THE POTENCY AND SELECTIVITY OF ANTI-HERPES COMPOUNDS (1979) (22)
Polymethacrylic Acid: Effects on Lymphocyte Output of the Thoracic Duct in Rats (1969) (22)
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives. (1992) (22)
SYNTHESIS OF 1-(2-DEOXY-β-D- RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENE THYMIDINE MIMICS,* SOME RELATED α-ANOMERS, AND THEIR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS (2001) (22)
Differential Susceptibility of Several Drug-Resistant Strains of Herpes Simplex Virus Type 2 to Various Antiviral Compounds (1997) (22)
Synthesis of aliphatic nucleoside analogues with potential antiviral activity (1983) (22)
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpe (1990) (22)
Antifungal and antibacterial activities of diarylamidine derivatives (1980) (22)
Serum, Pleural Effusion, and Ascites CA-125 Levels in Ovarian Cancer and Nonovarian Benign and Malignant Diseases: A Comparative Study (2002) (22)
Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. (2015) (22)
Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. (2013) (22)
Therapeutic potential of HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues as broad-spectrum antiviral agents (1997) (22)
Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives. (1990) (22)
Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. (2015) (22)
Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action (2003) (22)
SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF 4- AND 5-SUBSTITUTED 1,2,3-TRIAZOLE-TSAO DERIVATIVES (1995) (22)
Fluorescence-based antiviral assay for the evaluation of compounds against vaccinia virus, varicella zoster virus and human cytomegalovirus. (2008) (22)
Current Pharmacological Approaches to the Therapy of Varicella Zoster Virus Infections (1999) (22)
SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES, OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING. IV. ADENOSINE AND URIDINE ANALOGUES (2002) (22)
Comparative activity of various compounds against clinical strains of herpes simplex virus (1992) (22)
Polyanion inhibitors of human immunodeficiency virus and other viruses. 6. Micelle-like anti-HIV polyanionic compounds based on a carbohydrate core. (1997) (22)
Chromosome 21 does not code for an interferon receptor (1976) (22)
New acquisitions in the development of anti-HIV agents. (1989) (22)
Synthesis and anti-HIV activity evaluation of novel N′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides (2010) (22)
Nucleotides. Part. XXXII. Synthesis of 2′–5′ Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides† (1989) (22)
Synthesis of acyclowyosine and acyclo-3-methylguanosine, as probes for some chemical and biological properties resulting from the N-3 substitution of guanosine and its analogues (1991) (22)
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype (2001) (22)
Recent progress in small molecule CCR5 antagonists as potential HIV-1 entry inhibitors. (2012) (22)
TSAO DERIVATIVES: HIGHLY SPECIFIC INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) REPLICATION (1995) (22)
Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins. (1986) (22)
Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities. (1992) (22)
1,2,3‐Thiadiazole Thioacetanilides. Part 2 (2010) (22)
4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: a novel class of cytotoxic and anticancer agents. (1998) (22)
Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds. (2000) (22)
A 40-year journey in search of selective antiviral chemotherapy. (2011) (21)
3,5-Bis(Phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A Novel Group of Cytotoxic Agents (2003) (21)
3′-Spiro Nucleosides, a New Class of Specific Human Immunodeficiency Virus Type 1 Inhibitors: Synthesis and Antiviral Activity of (2′,5′- Bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and -ribofuranose)-3′- spiro-5′′-(4′′-amino-1′′,2′′-oxathiole 2′′,2′′-Dioxide) (TSAO) Pyrimidine Nucleosides. (1992) (21)
Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa. (2007) (21)
TSAO Analogues. Stereospecific Synthesis and Anti‐HIV‐1 Activity of 1‐( 2′,5′‐Bis‐O‐(tert‐butyldimethylsilyl)‐β‐D‐ribofuranosyl)‐3′‐spiro‐ 5′′‐(4′′‐amino‐1′′,2′′‐oxathiole 2′′,2′′‐dioxide)pyrimidine and Pyrimidine‐Modified Nucleosides. (1992) (21)
Stochastic entropy QSAR for the in silico discovery of anticancer compounds: prediction, synthesis, and in vitro assay of new purine carbanucleosides. (2006) (21)
Relationship of cytotoxicity and interferon-inducing activity of polyriboinosinic acid. Polyribocytidylic acid to the molecular weights of the homopolymers. (1974) (21)
In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses (2008) (21)
Biochemical aspects of the selective antiherpes activity of nucleoside analogues. (1984) (21)
Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents. (1992) (21)
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core. (2007) (21)
New Synthesis and Antitumor Activity of CycloSal- Derivatives of 5-Fluoro-2′-deoxyuridinemonophosphate (1997) (21)
Phosphonylmethoxyalkyl derivatives of purines and pyrimides: A new class of antiviral agents active against both herpesviruses and retroviruses☆ (1987) (21)
Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds. (1992) (21)
Recent advances in the research of HIV-1 RNase H inhibitors. (2008) (21)
Molecular design opportunities presented by solvent‐exposed regions of target proteins (2019) (21)
Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with AIDS. (1993) (21)
Synthesis and biological evaluation of some new 1,3,4-thiadiazole and 1,2,4-triazole derivatives from L-methionine as antituberculosis and antiviral agents (2015) (21)
AMD3100/CXCR4 Inhibitor (2015) (21)
Successful use of intralesional and intravenous cidofovir in association with indole‐3‐carbinol in an 8‐year‐old girl with pulmonary papillomatosis (2005) (21)
Protective effect of interferon and polyacrylic acid in newborn mice infected with a lethal dose of vesicular stomatitis virus. (1968) (21)
Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines (2002) (21)
Exploitation of the Low Fidelity of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase and the Nucleotide Composition Bias in the HIV-1 Genome To Alter the Drug Resistance Development of HIV (2001) (21)
Structure-activity of inhibition of HIV-1 integrase and virus replication by G-quartet oligonucleotides. (2001) (21)
Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety (1996) (21)
Interferon inducers: general survey and classification. (1981) (21)
E-5-(2-bromovinyl)-2'-deoxyuridine vs. interferon in the systemic treatment of infection with herpes simplex virus of athymic nude mice. (1981) (21)
New Approaches Toward anti-HIV Chemotherapy (2005) (21)
Oral antiviral drugs in experimental herpes simplex keratitis (1983) (21)
Synthesis and antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective antiherpes activity of 1-(beta-D-arabinofuranosyl)-5-ethyluracil. (1979) (21)
Homo Dinucleoside-α-hydroxyphosphonate Diesters as Prodrugs of the Antiviral Nucleoside Analogues 2′,3′-Dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine (1995) (21)
Alkoxy‐5‐nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds (2010) (21)
Treatment of severe recurrent laryngeal papillomatosis by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (Cidofovir®) (1996) (21)
Antiviral activity of ganciclovir elaidic acid ester against herpesviruses. (2000) (21)
Synthesis and Antiviral Evaluation of Phosphoramidate Derivatives of (E)-5-(2-Bromovinyl)-2′-Deoxyuridine (2001) (21)
Mannich bases of phenolic azobenzenes possessing cytotoxic activity (1997) (21)
Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates. (1981) (21)
Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study (2020) (21)
5-(Acylethynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5-(Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities (1999) (21)
Initiation of HAART in drug-naive HIV type 1 patients prevents viral breakthrough for a median period of 35.5 months in 60% of the patients. (2002) (21)
Novel agents for the therapy of varicella-zoster virus infections (2000) (21)
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity. (1988) (21)
Bromovinyldeoxyuridine treatment of herpetic keratitis clinically resistant to other antiviral agents. (1991) (21)
Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines (2006) (20)
Solvent-Free Synthesis of Pyrimidine Nucleoside-Aminophosphonate Hybrids and Their Biological Activity Evaluation (2010) (20)
In vitro Activity of Acyclic Nucleoside Phosphonate Derivatives against Feline Immunodeficiency Virus in Crandell Feline Kidney Cells and Feline Peripheral Blood Lymphocytes (1994) (20)
Ribosylation of pyrimidine 2'-deoxynucleosides (1996) (20)
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs. (2014) (20)
Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV (2003) (20)
Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors (2020) (20)
The human immunodeficiency virus(HIV) inhibitor 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) is a strong inducer of differentiation of several tumor cell lines (1995) (20)
Biological, biochemical, and physicochemical evidence for the existence of the polyadenylic-polyuridylic-polyinosinic acid triplex. (1975) (20)
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues (1999) (20)
Mechanism of antiviral and cytotoxic action of (+/-)-6' beta-fluoroaristeromycin, a potent inhibitor of S-adenosylhomocysteine hydrolase. (1991) (20)
Synthesis and anti-HIV activity of a bile acid analog of cosalane (2001) (20)
Bicyclic nucleoside inhibitors of varicella-zoster virus (VZV): effect of terminal unsaturation in the side-chain. (2001) (20)
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. (2021) (20)
Stimulation or inhibition of interferon production depending on time of cycloheximide administration. (1970) (20)
Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine. (1988) (20)
Synthesis, characterization and screening of antimicrobial, antituberculosis, antiviral and anticancer activity of novel1,3-thiazolidine-4-ones derived from 1-[2-(benzoylamino)-4-(methylthio)butyryl]-4-alkyl/arylalkyl thiosemicarbazides (2008) (20)
Mechanism of the Antiviral Activity Resulting from Sequential Administration of Complementary Homopolyribonucleotides to Cell Cultures (1972) (20)
Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N, E138K Mutants, and Pharmacokinetic Profiles. (2020) (20)
A Combination of Poor Adherence and a Low Baseline Susceptibility Score is Highly Predictive for HAART Failure (2002) (20)
Successful treatment of human papillomavirus (HPV) associated giant squamous papilloma of the hypopharynx and esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) (1994) (20)
Rat cytomegalovirus-induced pneumonitis after allogeneic bone marrow transplantation: effective treatment with (S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl)cytosine (1993) (20)
Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket. (2016) (20)
Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV+3TC) combination therapy in patients previously treated with ZDV+ddC (1996) (20)
Targets for the Antiviral and Antitumor Activities of Nucleoside, Nucleotide and Oligonucleotide Analogues (1985) (20)
Influence of various 2- and 2'-substituted polyadenylic acids on murine leukemia virus reverse transcriptase. (1979) (20)
The Phenylmethylthiazolylthiourea Nonnucleoside Reverse Transcriptase (RT) Inhibitor MSK-076 Selects for a Resistance Mutation in the Active Site of Human Immunodeficiency Virus Type 2 RT (2004) (20)
Tumor necrosis factor antagonizes inhibitory effect of azidothymidine on human immunodeficiency virus (HIV) replication in vitro. (1990) (20)
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues. (2005) (20)
Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors. (2019) (20)
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1-[1-(2-HYDROXYETHOXY)- METHYL-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO[3,4-d]PYRIMIDINES (2001) (20)
Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation. (2004) (20)
New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation. (2001) (20)
Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity. (2001) (20)
Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides. (1989) (20)
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines (2009) (20)
(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU). (2005) (20)
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket. (2016) (20)
Inhibition of coxsackie B3 virus induced myocarditis in mice by 2‐(3,4‐dichlorophenoxy)‐5‐nitrobenzonitrile (2004) (20)
Synthesis and biological evaluation of isomeric dinucleoside monophosphates and monomethylphosphonates of 9-beta-D-arabinofuranosyladenine and related analogues. (1988) (20)
Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. (2006) (20)
Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions (2010) (20)
Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections. (1997) (20)
Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1 (1997) (20)
A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate (2009) (20)
Prolonged herpes simplex virus latency in vitro after treatment of infected cells with acyclovir and human leukocyte interferon (1986) (20)
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides. (1989) (20)
Potentiating Effect of Freund's Adjuvant on Interferon Production by Endotoxin or Poly rI•Poly rC (1970) (19)
Coreceptor ligand inhibition of fetal brain cell infection by HIV type 1. (1999) (19)
Efficacy of (E)-5-(2-bromovinyl)-2′-deoxyuridine in the topical treatment of herpes simplex keratitis (2004) (19)
Induction of sister-chromatid exchange by 5-substituted 2'-deoxyuridines. (1983) (19)
Oxathiin Carboxanilide Derivatives: A Class of Non-Nucleoside HIV-1-Specific Reverse Transcriptase Inhibitors (NNRTIs) that are Active against Mutant HIV-1 Strains Resistant to other NNRTIs (1995) (19)
Chemotherapeutic agents for herpesvirus infections. (1986) (19)
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-moloney murine sarcoma virus activity in vivo (1989) (19)
Antiviral and antitumor activities of 5-substituted 2'-deoxyuridines. (1980) (19)
Antiviral activity of poly(7-deazainosinic acid)-derived complexes in vitro and in vivo. (1976) (19)
Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays. (2017) (19)
Targets and strategies for the antiviral chemotherapy of AIDS. (1990) (19)
Nicotinic Acid Benzylidene/Phenyl-Ethylidene Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Studies (2011) (19)
A rapid and convenient variant of fusion-PCR to construct chimeric flaviviruses. (2003) (19)
The synthesis and biological properties of some aryl bis(nucleosid-5'-YL) phosphates using nucleosides with proven anti-HIV activity (1992) (19)
Interferon induction by polynucleotides, modified polynucleotides, and polycarboxylates. (1981) (19)
Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates. (1981) (19)
Antiviral and Cytostatic Evaluation of the Novel 6-acyclic Chain Substituted Thymine Derivatives (2005) (19)
Polyanion inhibitors of human immunodeficiency virus and other viruses. 5. Telomerized anionic surfactants derived from amino acids. (1997) (19)
ANTI-HIV CHEMOTHERAPY: CURRENT STATE OF THE ART (2004) (19)
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs. (1995) (19)
Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues (2012) (19)
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine. (1990) (19)
Anti-Varicella—Zoster Virus Bicyclic Nucleosides: Replacement of Furo by Pyrro Base Reduces Antiviral Potency (2000) (19)
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. (2009) (19)
Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors. (1993) (19)
Hope and hype (2006) (19)
Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii. (2010) (19)
Inhibition of Intestinal Metabolism of the Antiviral Ester Prodrug bis(POC)-PMPA by Nature-Identical Fruit Extracts as a Strategy to Enhance Its Oral Absorption: An In Vitro Study (1999) (19)
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs. (2011) (19)
Xylotubercidin against herpes simplex virus type 2 in mice (1986) (19)
Potent nonclassical nucleoside antiviral drugs based on the N,N-diarylformamidine concept. (2004) (19)
Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus. (1992) (19)
In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses (1989) (19)
5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase. (1999) (19)
Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes, and paraductions (2009) (19)
Synthesis of 3‐Nitrosoimidazo[1,2‐a]pyridine Derivatives as Potential Antiretroviral Agents (2001) (19)
Current race in the development of DAAs (direct-acting antivirals) against HCV. (2014) (19)
Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils--their antiviral and cytotoxic activities. (1997) (19)
Inhibition of oncornavirus functions by 2'-azido polynucleotides. (1975) (19)
In vivo effect of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-carboxamide) on experimental infected rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch) fry with infectious pancreatic necrosis virus. (2000) (19)
Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (2015) (19)
Carrier Mechanisms Involved in the Transepithelial Transport of bis(POM)-PMEA and Its Metabolites Across Caco-2 Monolayers (1998) (19)
Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines. (2007) (19)
Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof. (2009) (19)
Elucidation of the mechanism by which homocysteine potentiates the anti-vaccinia virus effects of the S-adenosylhomocysteine hydrolase inhibitor 9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-adenine. (1989) (19)
Treatment of a bowenoid papulosis of the penis with local applications of cidofovir in a patient with acquired immunodeficiency syndrome. (2001) (19)
Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects. (2000) (19)
Specific therapies for human papilloma virus infections. (1998) (19)
Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus. (1990) (18)
Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport. (2009) (18)
Hamao Umezawa Memorial Award Lecture: "An Odyssey in the Viral Chemotherapy Field". (2001) (18)
Antimicrobial and Cytotoxic Activities of Turbinaria conoides (2010) (18)
Inhibitory effects of EICAR on infectious pancreatic necrosis virus replication. (2000) (18)
A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors (2005) (18)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile (2nd Edition): DNA Viruses (2008) (18)
Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation. (2004) (18)
Inhibitory effect of interferon on the growth of spontaneous mammary tumors in mice. (1982) (18)
Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse (1971) (18)
Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. (1987) (18)
Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors and Evaluation of Their Enzyme Inhibitory, Cytostatic and Antiviral Activity (2003) (18)
Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. (2007) (18)
Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine. (1991) (18)
Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections. (2018) (18)
Synthesis of Some Novel Thiourea Derivatives Obtained from 5‐[(4‐Aminophenoxy)methyl] ‐4‐alkyl/aryl‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and Evaluation as Antiviral/anti‐HIV and Antituberculosis Agents. (2008) (18)
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters. (1986) (18)
Chemotherapeutic efficacy of E-5-(2-bromovinyl)-2'deoxyuridine for orofacial infection with herpes simplex virus type 1 in mice. (1982) (18)
Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus. (1994) (18)
Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains. (2019) (18)
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. (2013) (18)
Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1,2,4-triazole clubbed benzothiazoles (2013) (18)
Role of the incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine and its carbocyclic analogue into DNA of herpes simplex virus type 1-infected cells in the antiviral effects of these compounds. (1990) (18)
Synthesis and Anti-Human Immunodeficiency virus Type 1 Activity of Novel 3′-Spiro Nucleoside Analogues of TSAO-T (1997) (18)
Interferon and Its Inducers—A Never-Ending Story: “Old” and “New” Data in a New Perspective (2006) (18)
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues. (2005) (18)
Coreceptor usage of sequential isolates from cynomolgus monkeys experimentally Infected with simian immunodeficiency virus (SIVsm). (2001) (18)
Synthesis of some analogues of 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (hept) which have different types of acyclic structures (1992) (18)
Retinoic acid conjugates as potential antitumor agents: synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties. (1997) (18)
Biological Activity of Some Dialkyl α-Anilinobenzylphosphonates and Their Palladium(II) Complexes (1995) (18)
Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel". (2018) (18)
Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents. (1995) (18)
Novel compounds in preclinical/early clinical development for the treatment of HIV infections (2000) (18)
Synthesis and cytotoxic evaluation of some styryl ketones and related compounds (1995) (18)
Activation of herpes simplex virus (HSV) type 1 genome by temperature-sensitive mutants of HSV type 2. (1982) (18)
The antitumor potency of oral tegafur against adenocarcinoma 755 in mice is markedly enhanced by oral (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1987) (18)
Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase. (1999) (18)
Kinetic Properties of Adenine Nucleotide Analogues Against Purified 5-Phosphoribosyl-1-pyrophosphate Synthetases from E. coli, Rat Liver and Human Erythrocytes (1995) (18)
A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1. (1996) (18)
Aryl-Substituted and Benzo-Annulated CycloSal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity (2002) (18)
Synthesis, Antiviral, Antituberculostic, and Antibacterial Activities of Some Novel, 4‐(4‐substituted phenyl)‐6‐(4‐nitrophenyl)‐2‐(substituted imino)pyrimidines (2007) (18)
Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4. (1999) (18)
Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors (2019) (17)
Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT. (2001) (17)
Inhibition of Human Immunodeficiency Virus Type (HIV‐1) Replication by some Diversely Functionalized Spirocyclopropyl Derivatives (1999) (17)
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach. (2014) (17)
Recent trends and development in antiviral chemotherapy. (1985) (17)
A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity. (2002) (17)
Resistance of human immunodeficiency virus type 1 (HIV-1) to non-nucleoside HIV-1-specific reverse transcriptase inhibitors (1994) (17)
The Amino Acid Asn136 in HIV-1 Reverse Transcriptase (RT) Maintains Efficient Association of Both RT Subunits and Enables the Rational Design of Novel RT Inhibitors (2005) (17)
Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine. (1998) (17)
John Montgomery's Legacy: Carbocyclic Adenosine Analogues as Sah Hydrolase Inhibitors with Broad-Spectrum Antiviral Activity (2005) (17)
Relationship between cell-interaction and antiviral activity of polyriboinosinic acid-polyribocytidylic acid in different cell cultures. (1973) (17)
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective (2021) (17)
Nitroimidazoles, part 4: Synthesis and anti‐HIV activity of new 5‐alkylsulfanyl and 5‐(4′‐arylsulfonyl)piperazinyl‐4‐nitroimidazole derivatives (2007) (17)
Studies on the Mechanism of the Priming Effect of Interferon on Interferon Production by Cell Cultures Exposed to Poly(rI) · Poly(rC) (1973) (17)
Tenofovir: Quo Vadis Anno 2012 (Where Is It Going in the Year 2012)? (2012) (17)
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. (1987) (17)
Cytostatic activity of novel 4'-aminochalcone-based imides. (2007) (17)
Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from $N$-(arylsulfonyl)methionine (2016) (17)
Purification of mouse interferon by sequential chromatography. (1979) (17)
Interferon induction by two 2'-modified double-helical RNAs, poly(2'-fluoro-2'-deoxyinosinic acid) x poly(cytidylic acid) and poly(2'-chloro-2'-deoxyinosinic acid) x poly(cytidylic acid). (1980) (17)
Recent advances in the research of 2,3-diaryl-1,3-thiazolidin-4-one derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. (2012) (17)
Synthesis and Anti‐HIV Activity of 4‐(Naphthalen‐1‐yl)‐1,2,5‐thiadiazol‐3‐hydroxyl Derivatives (2014) (17)
Guanosine Analogues as Anti-Herpesvirus Agents (2000) (17)
Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs. (2019) (17)
Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm. (2010) (17)
Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells. (1990) (17)
Structural investigation and anti-HIV activities of high molecular weight ATA polymers (1992) (17)
Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action. (2015) (17)
New Developments in the Chemotherapy of Lentivirus (Human Immunodeficiency Virus) Infections: Sensitivity/Resistance of HIV‐1 to Non‐nucleoside HIV‐1‐specific Inhibitors a (1994) (17)
Sepharose-bound poly (I)-poly (C): interaction with cells and interferon production. (1975) (17)
Synthesis and biological evaluation of phosphonopyrimidine and phosphonopurine ribonucleosides. (1987) (17)
Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors (2012) (17)
The immunosuppressive agent mycophenolate mofetil markedly potentiates the activity of lobucavir [1R(1alpha,2beta,3alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine against different herpes viruses. (1999) (17)
Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo. (2001) (17)
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase. (2001) (17)
Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring. (1999) (17)
Investigation of 1 , 3 , 4-Oxadiazole Scaffold as Potentially Active Compounds (2011) (17)
Inhibitory Effects of Polycations on the Replication of Enveloped Viruses (HIV, HSV, CMV, RSV, Influenza A Virus and Togaviruses) in vitro (1991) (17)
Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro. (1987) (17)
Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines. (1983) (17)
Relationship between structure and antiviral activity of 5-methoxymethyl-2'-deoxyuridine and 5-methoxymethyl-1-(2'-deoxy-beta-D-lyxofuranosyl)uracil. (1987) (17)
Chemotherapy of varicella zoster virus infections. (1994) (17)
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues. (2006) (17)
Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. (2010) (17)
Specific targets for antiviral drugs. (1982) (17)
Baseline HIV type 1 genotypic resistance to a newly added nucleoside analog is predictive of virologic failure of the new therapy. (2000) (17)
Design, synthesis and biological evaluation of novel curcumin analogues as anti-neoplastic agents (2006) (17)
Non‐Nucleoside Reverse Transcriptase Inhibitors (NNRTIs): Past, Present, and Future (2004) (17)
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 4-SUBSTITUTED 1-[1-(4-HYDROXYBUTYL)-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO-[3,4-d]PYRIMIDINES (2001) (17)
Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle. (2004) (17)
Recovery of Humoral Immunity Is Critical for Successful Antiviral Therapy in Disseminated Mouse Adenovirus Type 1 Infection (2008) (17)
The race for interferon‐free HCV therapies: a snapshot by the spring of 2012 (2012) (17)
Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates. (2012) (17)
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. (2022) (17)
Synthesis and biological activity of 3'-azido- and 3'-amino substituted nucleoside analogs (1985) (17)
Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice. (2003) (17)
Synthesis and stereochemical characterisation of platinum(II) complexes with the antiviral agents penciclovir and famciclovir (2003) (17)
Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids. (2004) (17)
5′,5′‐di‐O‐nucleosyl‐O′‐benzylphosphotriesters as potential prodrugs of 3′‐azido‐2′,3′‐dideoxythymidine‐5′‐monophosphate (1995) (17)
Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐d]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors (2018) (16)
Inhibitory effects of selected antiviral compounds on newly isolated clinical varicella-zoster virus strains. (1986) (16)
Human Herpesvirus 8 Gene Encodes a Functional Thymidylate Synthase (2002) (16)
Synthesis, properties, and biological activity of some nucleoside cyclic phosphoramidates (1984) (16)
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents. (2010) (16)
Effects of E-5-(2-bromovinyl)-2'-deoxyuridine and other selective anti-herpes compounds on the induction of retrovirus particles in mouse BALB/3T3 cells. (1981) (16)
Design, Synthesis, and Anti‐HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket (2015) (16)
New Anti-HIV Agents in Preclinical or Clinical Development (2003) (16)
Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anti-cytomegalovirus agents. (1991) (16)
Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds. (2002) (16)
Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides. (1996) (16)
Highly potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by the HIV-1-specific reverse transcriptase inhibitors (1992) (16)
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones. (2004) (16)
Resistance development of human immunodeficiency virus-1 against diketo derivatives (2003) (16)
A continuous high molecular weight base‐paired structure is not an absolute requirement for a potential polynucleotide inducer of interferon (1977) (16)
Desferrioxamine enhances aids‐associated Kaposi's sarcoma tumor development in a xenograft model (2002) (16)
Antimicrobial and Cytotoxic Activities of Turbinariaconoides (J.Agardh) Kuetz (2010) (16)
Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine (1989) (16)
Cellular Alteration by Interferon: a Virus-Free System for Assaying Interferon (1972) (16)
Modified Cyclodextrin Sulphates(mCDS11) have Potent Inhibitory Activity against HIV and High Oral Bioavailability (1994) (16)
Advances in antiviral drug design (1993) (16)
Imidazothiadiazine dioxides: synthesis and antiviral activity. (1999) (16)
Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation. (2004) (16)
Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives (2014) (16)
Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo. (1989) (16)
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine (2005) (16)
Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells. (1990) (16)
Synthesis and evaluation of antiviral , antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones (2010) (16)
Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives (2007) (16)
Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties. (1997) (16)
Anti-HIV Derivatives of 1-(2,3-Dideoxy-3-N-hydroxyamino-β-D-threo-pentofuranosyl)thymine (1994) (16)
Lithiation of Uracilnucleosides and its Application to the Synthesis of a New Class of Anti-HIV-1 Acyclonucleosides (1991) (16)
Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations. (1998) (16)
Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins. II. (1997) (16)
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid). (1975) (16)
New therapeutic approaches targeted at the late stages of the HIV-1 replication cycle. (2011) (16)
Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent. (2008) (16)
Human viral diseases: what is next for antiviral drug discovery? (2012) (16)
5-Substituted uracil arabinonucleosides as potential antiviral agents. (1979) (16)
New Polyacetal Polysulphate Active against Human Immunodeficiency Virus and other Enveloped Viruses (1992) (16)
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential. (2015) (16)
Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues. (2003) (16)
Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP (1997) (16)
Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor organotin complexes (1989) (16)
Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents (2012) (16)
The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase. (2002) (16)
New inhibitors of human cytomegalovirus (HCMV) on the horizon. (2003) (16)
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes. (2000) (16)
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses (2010) (16)
Viruses and Viral Diseases (2007) (16)
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits. (1991) (16)
Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1983) (15)
Potent and Selective Inhibition of HIV and SIV by Prostratin Interacting with Viral Entry (2003) (15)
Degradation of poly(inosinic acid) - poly(cytidylic acid) [(I)n - (C)n] by human plasma. (1979) (15)
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system. (1994) (15)
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine in the treatment of intracerebral murine cytomegalovirus infections in immunocompetent and immunodeficient mice (1993) (15)
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. (1998) (15)
Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides. (2002) (15)
Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity (1996) (15)
Interferon induction by and ribonuclease sensitivity of thiophosphate-substituted polyribonucleotides. (1969) (15)
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors. (2012) (15)
Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs? (2003) (15)
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine. (1998) (15)
The Acyclic Nucleoside Phosphonates (ANPs): Antonín Holý's Legacy (2013) (15)
Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine. (1985) (15)
Biological activity and a modified synthesis of 8-amino-3-beta-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, an isomer of formycin. (1984) (15)
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles. (2005) (15)
Diagnosis of human immunodeficiency virus infection by a polymerase chain reaction assay evaluated in patients harbouring strains of diverse geographical origin. (1998) (15)
Comparative inhibition of DNA polymerases from varicella zoster virus (TK+ and TK-) strains by (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate. (1984) (15)
Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine. (2006) (15)
Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase. (2004) (15)
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries. (2017) (15)
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach. (2002) (15)
Hydroxyurea Potentiates the Antiherpesvirus Activities of Purine and Pyrimidine Nucleoside and Nucleoside Phosphonate Analogs (1999) (15)
Chemotherapy of respiratory syncytial virus infections: the final breakthrough. (2015) (15)
Inhibition of terminal N- and O-glycosylation specific for herpesvirus-infected cells: mechanism of an inhibitor of sugar nucleotide transport across Golgi membranes. (1988) (15)
Antiviral activity of polynucleotides: poly(2'-fluoro-2'-deoxyuridylic acid). (1973) (15)
Discovery of Piperidine‐Linked Pyridine Analogues as Potent Non‐nucleoside HIV‐1 Reverse Transcriptase Inhibitors (2013) (15)
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach. (2012) (15)
Screening of Compounds for Activity against HIV: A Collaborative Study (1991) (15)
Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle. (2010) (15)
Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine. (1990) (15)
Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine. (1996) (15)
Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. (1989) (15)
Interferon clearance rate decreased after repeated injections. (1971) (15)
Development of resistance of human immunodeficiency virus (HIV) to anti-HIV agents: how to prevent the problem? (1997) (15)
Thymidylate synthetase-deficient mouse FM3A mammary carcinoma cell line as a tool for studying the thymidine salvage pathway and the incorporation of thymidine analogues into host cell DNA. (1984) (15)
Novel Nucleoside Phosphoramidates as Inhibitors of HIV: Studies on the Stereochemical Requirements of the Phosphoramidate Amino Acid (1996) (15)
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement. (2017) (15)
Effect of human and mouse interferon and of polyriboinosinic acid.polyribocytidylic acid on the growth of human fibrosarcoma and melanoma tumors in nude mice. (1978) (15)
Sister chromatid exchange induced by anti-herpes drugs. (1981) (15)
Ebola virus (EBOV) infection: Therapeutic strategies (2014) (15)
5-(2-Chloroethyl)-2'-deoxyuridine: a potent and selective inhibitor of herpes viruses in vitro and in vivo. (1985) (15)
Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor (2007) (15)
Inhibitory Effect of Pyridobenzoazoles on Orthomyxo-and Paramyxovirus Replication in vitro (1992) (15)
New perspectives for the treatment of HIV infections. (1998) (15)
Activity of several S-adenosylhomocysteine hydrolase inhibitors against African swine fever virus replication in Vero cells. (1993) (15)
Thymidine Phosphorylase is Noncompetitively Inhibited by 5′-O-Trityl-Inosine (KIN59) and Related Compounds (2006) (15)
Differential effects of various double-stranded RNAs on protein synthesis in rabbit reticulocyte lysates. (1978) (15)
Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues (1991) (15)
Synthesis, antifungal, antibacterial and antiviral effects of some adamantaneketoxime ethers. (1993) (15)
The antiviral spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1984) (15)
Antiviral activity of selected nucleoside analogues against human herpes virus type 6 (1995) (15)
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents. (1990) (15)
Stereoselective Synthesis of Sugar-Modified Enyne Analogues of Adenosine and Uridine. Interaction with S-Adenosyl-L-homocysteine Hydrolase and Antiviral and Cytotoxic Effects (2004) (15)
Antiviral therapy for human immunodeficiency virus infections (1995) (15)
Evolution of HIV drug Resistance in Zidovudine/Zalcitabine- and Zidovudine/ Didanosine-Experienced Patients Receiving Lamivudine-Containing Combination Therapy (1998) (15)
Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents (2015) (15)
Mouse adenovirus type 1 attachment is not mediated by the coxsackie‐adenovirus receptor (2006) (14)
Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era. (2012) (14)
Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives (2006) (14)
Synthesis and anti-HIV activity of some new aminoadamantane heterocycles (1997) (14)
Development of antiviral drugs for the treatment of hepatitis C at an accelerating pace. (2015) (14)
Synthesis and Biological Evaluation of a Series of 2‐((1‐substituted‐1H‐1,2,3‐triazol‐4‐yl)methylthio)‐6‐(naphthalen‐1‐ylmethyl)pyrimidin‐4(3H)‐one As Potential HIV‐1 Inhibitors (2015) (14)
Therapeutic potential of PMEA as an antiviral drug (1994) (14)
Influence of intravitreal injections of HPMPC and related nucleoside analogues on intraocular pressure in guinea pig eyes. (1998) (14)
Synthesis, and cytotoxic activity of N(ind)-alkoxy derivatives of antibiotic arcyriarubin and dechloro-rebeccamycin aglycon. (2002) (14)
Antihistaminic and antiviral activities of steroids of Turbinaria conoides (2011) (14)
Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 6-substituted purine and 8-azapurine. (1999) (14)
Synthesis and Preliminary Antiviral Activities of Piperidine‐substituted Purines against HIV and Influenza A/H1N1 Infections (2015) (14)
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus. (2001) (14)
Selective Inhibition of Porcine Endogenous Retrovirus Replication in Human Cells by Acyclic Nucleoside Phosphonates (2007) (14)
The Unabated Synthesis of New Nucleoside Analogues with Antiviral Potential: A Tribute to Morris J. Robins (2009) (14)
Susceptibility of bovid herpesvirus 1 to antiviral drugs: in vitro versus in vivo efficacy of (E)-5-(2-Bromovinyl)-2'-deoxyuridine (1983) (14)
Differential Effects of E-5-(2-Bromovinyl)-2'-Deoxyuridine on Infections with Herpes Simplex Virus Type 1 and Type 2 in Hairless Mice (1982) (14)
Antiviral activity of O'-alkylated derivatives of cytosine arabinoside. (1975) (14)
Antiviral drug strategies. (2011) (14)
3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties. (1992) (14)
1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells. (2008) (14)
Prolonged Antiviral Protection by Interferon Inducers (1969) (14)
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (2007) (14)
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase. (1998) (14)
Pd-catalyzed C-C bond-forming reactions of thymidine mesitylene sulfonate. (2007) (14)
Are cytotoxicity and interferon inducing activity of poly(I).poly(C) invariably linked in interferon-treated L cells. (1975) (14)
Synthesis, spectroscopic characterization, antineoplastic, in vitro-cytotoxic, and antibacterial activities of mononuclear ruthenium(II) complexes (2012) (14)
Lipophilic α‐hydroxybenzylphosphonates as prodrugs of 3′‐azido‐2′,3′‐dideoxythymidine (AZT) (1995) (14)
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition. (1980) (14)
Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond. (2004) (14)
Thiosugars. Part 9: synthesis and biological evaluation of some 4'-thio-L-arabino nucleoside analogues. (2001) (14)
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2. (2000) (14)
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors. (2014) (14)
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins. (2016) (14)
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency. (1999) (14)
Selective anti-herpes activity of 5-(2-halogenovinyl)-2'-deoxyuridines and 2'-deoxycytidines (1981) (14)
Role of Interferon in the Protective Effect of the Double-Stranded Polyribonucleotide Against Murine Tumors Induced by Moloney Sarcoma Virus (1971) (14)
Development of a cell-based enzyme-linked immunosorbent assay for high-throughput screening of HIV type 1 entry inhibitors targeting the coreceptor CXCR4. (2003) (14)
Inhibitory effect of a broad-spectrum antiviral agent, (S)-9-(2,3-dihydroxypropyl)adenine, on spermatogenesis in mice. (1981) (14)
Practice vs. laboratory tests for plastic injection moulding (2001) (14)
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. (2008) (14)
Interferon inducing activity of polyinosinic acid. (1978) (14)
Capsid (CA) protein as a novel drug target: recent progress in the research of HIV-1 CA inhibitors. (2009) (14)
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells. (1996) (14)
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP. (2020) (14)
Synthesis and Anti-Varicella-Zoster Virus Activity of Some Novel Bicyclic Nucleoside Inhibitors: Effect of Enhanced Aqueous Solubility (2000) (14)
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine. (1992) (14)
Molecular Targets for Antiviral Agents (2001) (14)
Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters. (1986) (14)
1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants (2009) (14)
Effect of mouse interferon and polyriboinosinic acid-polyribocytidylic acid on L-cell tumor growth in nude mice. (1977) (14)
In vitro Activity of Polyhydroxycarboxylates against Herpesviruses and Hiv (2001) (14)
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy (2020) (14)
Perspectives for the chemotherapy of AIDS. (1988) (14)
Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain. (2002) (14)
Dipyridamole Potentiates the Activity of Various Acyclic Nucleoside Phosphonates against Varicella-Zoster Virus, Herpes Simplex Virus and Human Cytomegalovirus (1994) (14)
Antiviral Activity Spectrum of Nucleoside and Nucleotide Analogues (1991) (13)
Evolution of anti-HIV drug candidates. Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU). (2001) (13)
Benzothiadiazine dioxide acyclonucleosides as lead compounds for the development of new agents against human cytomegalovirus and varicella-zoster virus infections (1997) (13)
Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 13 (2009) (13)
Nitroimidazoles, Part 2 (2006) (13)
Synthesis and Biological Evaluation of 6‐Substituted 5‐Alkyl‐2‐(phenylaminocarbonylmethylthio)pyrimidin‐4(3H)‐ones as Potent HIV‐1 NNRTIs (2011) (13)
Antiviral Agents That Are Active against CMV: Potential of Cidofovir for the Treatment of CMV and Other Virus Infections (1998) (13)
Cyclo-Saligenyl-3′-Azido-2′,3′-Dideoxy- Thymidinemonophosphate (cycloSal-AZTMP) - A New Pro-Nucleotide Approach1 ?- (1997) (13)
2′-C-ALKOXY AND 2′-C-ARYLOXY DERIVATIVES OF N-(2-PHOSPHONOMETHOXYETHYL)-PURINES AND -PYRIMIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY (2001) (13)
RECENT DEVELOPMENTS IN THE CHEMOTHERAPY OF HIV INFECTIONS (1998) (13)
Cytotoxic 4'-aminochalcones and related compounds. (2003) (13)
New 1,2,6-thiadiazine dioxide acyclonucleosides: synthesis and antiviral evaluation. (1995) (13)
Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents (2014) (13)
Antiviral and Anticellular Activities of Human and Murine Type I and Type II Interferons in Human Cells Monosomic, Disomic, and Trisomic for Chromosome 21 (1982) (13)
Cytotoxic and Topographical Properties of 6-Arylidene-2-dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds (2004) (13)
Synthesis and biological evaluation of acyclic nucleotide analogues with a furo(2,3-d)pyrimidin- 2(3H)-one base (2010) (13)
Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents (2012) (13)
Productive Infection of Primary Macrophages with Human Herpesvirus 7 (2001) (13)
Prolonged antiviral protection by interferon inducers. (1969) (13)
Protective effects of anionic detergents on interferons: reversible denaturation. (1974) (13)
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study. (1989) (13)
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents (2012) (13)
Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity. (1998) (13)
Managing Resistance to Anti-HIV Drugs (1999) (13)
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity. (2004) (13)
New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A. (1997) (13)
Approved HIV reverse transcriptase inhibitors in the past decade (2021) (13)
Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections (1996) (13)
Oral BVDU treatment of varicella and zoster in children with cancer (2004) (13)
Interferon Induction: Tool for Establishing Interactions among Homopolyribonucleotides (1974) (13)
Crystal Structure of (S)-1-Phenylethylammonium (R)-Mandelate and a Comparison of Diastereomeric Mandelate Salts of 1-Phenylethylamine. (1994) (13)
Reverse transcriptase fidelity and HIV-1 variation. (1997) (13)
Synthesis and Antiviral Properties of Aza-Analogues of Acyclovir (2007) (13)
Regression of autochthonous Moloney sarcoma virus-induced tumors in mice treated with polyriboinosinic acid-polyribocytidylic acid. (1974) (13)
Different Heterocycles Functionalized s‐Triazine Analogues: Design, Synthesis and In Vitro Antimicrobial, Antituberculosis, and Anti‐HIV Assessment (2014) (13)
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents. (1996) (13)
Syntheses of 4-[1-(2-deoxy-β-D-ribofuranosyl)]-derivatives of 2-substituted-5-fluoroaniline: "cytosine replacement" analogs of deoxycytidine for evaluation as anticancer and antihuman immunodeficiency virus (anti-HIV) agents (2000) (13)
Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and recombinant alpha interferon. (1991) (13)
Chemotherapy of human immunodeficiency virus (HIV) infection: anti-HIV agents targeted at early stages in the virus replicative cycle. (1996) (13)
Synthesis of 2-carbamoylmethyl-6-β-D-ribofuranosylpyridine with the aid of a Pd(0)-catalyzed reaction† (1993) (13)
Thiazolo[4,5-d]Pyrimidines. Part II. Synthesis and Anti-Human Cytomegalovirus Activity in Vitro of Certain Acyclonucleosides and Acyclonucleotides Derived from the Guanine Analogue 5-Aminothiazolo[4,5-d]Pyrimidine-2,7(3H,6H)-Dione (1998) (13)
3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine (2009) (13)
Evaluation of bromovinyldeoxyuridine-related compounds in the treatment of experimental herpes simplex keratitis. (1985) (13)
Structure—Antiviral Activity Relationship in the Series of Pyrimidine and Purine N-[2-(2-Phosphonomethoxy)ethyl] Nucleotide Analogues. Part 1. Derivatives Substituted at the Carbon Atoms of the Base. (1999) (13)
Increased Toxicity of Double-Stranded Ribonucleic Acid in Virus-Infected Animals (1973) (13)
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs. (2017) (13)
Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine. (1990) (13)
Synthesis of Pyranose Nucleosides (1991) (13)
Metabolism of the carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells. Incorporation of C-IVDU into DNA. (1985) (13)
Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain (2009) (13)
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) (13)
Historical perspectives in the development of antiviral agents against poxviruses. (2010) (13)
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds. (2008) (13)
Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)? (2012) (13)
The history of antiretrovirals: key discoveries over the past 25 years (2009) (13)
Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine. (2001) (13)
Nonviral Interferon Inducers (1970) (13)
Mechanism of binding of mouse interferon to controlled pore glass. (1979) (12)
Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells. (1995) (12)
Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues. (2003) (12)
Synthesis and Biological Evaluation of a Series of Substituted 2-Pyridine C-Nucleosides: I. Coupling reaction of organo-metallic pyridine compounds with 2,4:3,5-di-O-benzylidene-aldehydo-D-ribose. (1985) (12)
The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A (2005) (12)
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5′-deoxy-5-fluorouridine against adenocarcinoma 755 in mice: Correlation with pharmacokinetics of plasma 5-fluorouracil levels (1989) (12)
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid). (1977) (12)
Efficacy of E-5-(2-Bromovinyl)-2′-Deoxyuridine in the Topical Treatment of Herpetic Keratitis in Rabbits and Man (1981) (12)
Comparative Study of Bis(Benzyl)Phosphate Triesters of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine (d4T) and CycloSal-d4TMP — Hydrolysis, Mechanistic Insights and Anti-HIV Activity (2002) (12)
The race for interferon‐free HCV therapies: a snapshot by the spring of 2012 (2012) (12)
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity. (2006) (12)
Arylazolyl(azinyl)thioacetanilides: Part 19 : Discovery of Novel Substituted Imidazo[4,5‐b]pyridin‐2‐ylthioacetanilides as Potent HIV NNRTIs Via a Structure‐based Bioisosterism Approach (2016) (12)
1,2,4-Triazole derivatives inhibiting the human immunodeficiency virus type 1 (HIV-1) in vitro (2002) (12)
Synthesis of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol (2004) (12)
Role of deoxycytidine kinase in the inhibitory activity of 5-substituted 2'-deoxycytidines and cytosine arabinosides on tumor cell growth. (1983) (12)
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on replication of Epstein-Barr virus in human lymphoblastoid cell lines. (1985) (12)
The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues. (1998) (12)
2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase. (2001) (12)
Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors. (2014) (12)
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing. (2019) (12)
9-(2-Aryloxyethyl) Derivatives of Adenine - a New Class of Non-nucleosidic Antiviral Agents (2003) (12)
Synthesis and antiviral activity of some sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine (1981) (12)
Impact of 9‐(2‐phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells (1999) (12)
Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents (2010) (12)
3'-Fluoro- and 3'-azido-substituted 2',3'-dideoxynucleosides: a structure-activity relationship study (1991) (12)
Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides (1996) (12)
Synthesis and Cytostatic Activities of New 6-Substituted Purinylcarbonucleosides Derived from Indan (2002) (12)
Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase. (2020) (12)
Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies (2007) (12)
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on life-span and 5-fluorouracil metabolism in mice with hepatic metastases. (1990) (12)
Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism. (2004) (12)
Are cytotoxicity and interferon inducing activity of poly(I).poly(C) invariably linked in interferon-treated L cells. (1975) (12)
Preclinical assessment of topical treatments of herpes simplex virus infection: 5% (E)-5-(2-bromovinyl)-2'-deoxyuridine cream. (1985) (12)
Phosphorylation of nucleoside analogs by equine herpesvirus type 1 pyrimidine deoxyribonucleoside kinase. (1987) (12)
A newly developed immunofluorescent assay for determining the Pichinde virus-inhibitory effects of selected nucleoside analogues. (1988) (12)
Comparative Study of the Efficacy of Different Forms of Interferon Therapy in the Treatment of Mice Challenged Intranasally with Vesicular Stomatitis Virus (VSV) (1971) (12)
Synthesis, Structural Characterisation and Biological Activity of Zn(II) and Pd(II) Complexes of 3-Substituted 5-(2'-Pyridyl)- 1, 4-benzodiazepin-2-one Derivatives (2002) (12)
Targets for the Antiviral Activity of Pyrimidine and Purine Nucleoside Analogues (1987) (12)
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine. (1981) (12)
Human immunodeficiency virus inhibitors targeted at virus-cell fusion and/or viral uncoating (1992) (12)
9-Beta-D-arabinofuranosyladenine 5'-monophosphate (araAMP) is converted directly to its antivirally active 5'-triphosphate form by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase. (1990) (12)
Protective effect of interferon and polyacrylic acid in newborn mice infected with a lethal dose of vesicular stomatitis virus. (1968) (12)
Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach. (2016) (12)
In search of specific inhibitors of retrovirus replication. (1985) (12)
Synthesis and antiviral activity of 6-chloropurine arabinoside and its 2'-deoxy-2'-fluoro derivative. (1996) (12)
A mercapto analogue of 5'-noraristeromycin. (2002) (12)
Differential inhibition of herpes simplex viruses, type 1 (HSV-1) an type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2'-deoxyuridines. (1981) (12)
Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues. (2006) (12)
Pre-exposure chemoprophylaxis of HIV infection: quo vadis? (2012) (12)
Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. (2020) (12)
Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation (2021) (12)
Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins (2004) (12)
3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents. (2001) (12)
Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides. (2000) (12)
Topical Bromovinyldeoxyuridine Treatment of Herpes Simplex Keratitis (1985) (12)
The cyclophilin inhibitor Debio-025 is a potent inhibitor of hepatitis C virus replication in vitro with a unique resistance profile (2006) (12)
Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors. (2014) (12)
Acyclic purine nucleoside phosphonates as retrovirus inhibitors (1995) (12)
Design and Synthesis of Regioisomeric Analogues of a Specific Anti-HIV-1 Agent 1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) (1994) (12)
Bone marrow transplantation in a child with Wiskott-Aldrich syndrome latently infected with acyclovir-resistant (ACV(r)) herpes simplex virus type 1: emergence of foscarnet-resistant virus originating from the ACV(r) virus. (2002) (12)
Integrity of cell-bound poly(I).poly(C). (1974) (12)
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential. (2015) (12)
Oligo(2'-5')adenylate synthetase in human lymphoblastoid cells. (1980) (12)
Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents (1998) (12)
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues. (1991) (12)
Characterization of a varicella-zoster virus variant with altered thymidine kinase activity (1986) (12)
Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients. (1991) (12)
Nucleoside-catabolizing enzyme activities in primary rabbit kidney cells and human skin fibroblasts. (1978) (12)
Gliotoxin analogues as inhibitors of reverse transcriptase. 2. Resolution and X-ray crystal structure determination. (1978) (12)
Acyclic Nucleoside Phosphonates: An Unfinished Story (2011) (12)
Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture. (1999) (12)
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the treatment of experimental herpes simplex virus encephalitis in mice. (1983) (12)
Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents (2001) (11)
Interferon and Its Inducers—A Never-Ending Story: “Old” and “New” Data in a New Perspective (2006) (11)
The Nucleotide Analog Cidofovir Suppresses Basic Fibroblast Growth Factor (FGF2) Expression and Signaling and Induces Apoptosis in FGF2-Overexpressing Endothelial Cells (2007) (11)
Protection of rabbits against local vaccinia virus infection by Brucella abortus and polyacrylic acid in the absence of systemic interferon production. (1973) (11)
Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats. (2005) (11)
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model (2003) (11)
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. (2001) (11)
Synthesis, antiviral, antibacterial and antitumor cell activities of 2'-deoxy-2'-fluoropuromycin. (1995) (11)
Antiviral Activity of a Keggin Polyoxotungstate PM-19 against Herpes Simplex Virus in Mice (1994) (11)
Current treatment of hepatitis B virus infections (2015) (11)
Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues. (1998) (11)
Synthesis, spectroscopic characterization, in vitro cytotoxic and structure activity relationships of some mononuclear Ru(II) complexes (2013) (11)
Arylazolylthioacetanilide. Part 11: design, synthesis and biological evaluation of 1,2,4-triazole thioacetanilide derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (2013) (11)
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region. (1999) (11)
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients. (2000) (11)
Specific HIV-1 reverse transcriptase inhibitors. (1992) (11)
Chemical crosslinking of the subunits of HIV‐1 reverse transcriptase (1996) (11)
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil and ftorafur against adenocarcinoma 755 in mice. (1987) (11)
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides. (1989) (11)
Therapy of varicella-zoster virus infection--mechanism of action of (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1985) (11)
Highly Stereoselective Synthesis and Biological Properties of Nucleoside Analogues Bearing a Spiro Inserted Oxirane Ring (2000) (11)
In vitro anti-HIV activity profile of AMD887, a novel CCR5 antagonist, in combination with the CXCR4 inhibitor AMD070 (2004) (11)
Emerging antiviral drugs. (2008) (11)
Synthesis and Anti‐HIV Activity of 2‐, 3‐, and 4‐Substituted Analogues of 1‐((2‐Hydroxyethoxy)methyl)‐6‐(phenylthio)thymine (HEPT). (1991) (11)
Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2015) (11)
Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones. (2016) (11)
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. (2018) (11)
Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors (2014) (11)
Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors. (1990) (11)
BICYCLIC NUCLEOSIDE INHIBITORS OF VARICELLA-ZOSTER VIRUS (VZV): EFFECT OF TERMINAL UNSATURATION IN THE SIDE-CHAIN (2001) (11)
Synthesis and Antiviral Activity of Some 5′-N-Phthaloyl-3′-Azido-2′,3′-Dideoxythymidine Analogues (2003) (11)
Isothiazole Derivatives as Novel HIV Replication Inhibitors (2004) (11)
Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues (1996) (11)
Synthesis and biological evaluation of 4-quinolone ribosides (1993) (11)
Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV‐1 RNase H inhibitors (2019) (11)
Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains. (2019) (11)
The chemistry of 2' ,3'-seconucleosides II. Reactions and biological properties of 2',3'-secopyrimidine ribonucleosides (1985) (11)
Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine. (1986) (11)
Antimetabolic activities of 2-fluoro-L-histidine. (1978) (11)
Production of interferon in rabbit cell cultures by mouse L cell-bound poly(rI).poly(rC). (1972) (11)
New treatments for genital herpes. (2002) (11)
Antiviral Activity of Nucleoside Analogues: The BVDU Connection (2002) (11)
Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines (2004) (11)
Tanovea® for the treatment of lymphoma in dogs. (2018) (11)
Synthesis and Biophysical and Biological Properties of Oligonucleotides Containing 2-Aza-2'-Deoxyinosine (1995) (11)
Thermal activation of the antiviral activity of synthetic polyribonucleotides: influence of DEAE-dextran in various cell cultures (1971) (11)
Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1. (2020) (11)
Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase. (1997) (11)
Synthesis of 2',3'-dideoxy-3-isoadenosine : a new structural analogue of the anti-HIV active compound, 2,3'-dideoxyadenosine (1991) (11)
ANTIVIRAL ACTIVITY OF ALIPHATIC NUCLEOSIDE ANALOGS: STRUCTURE-FUNCTION RELATIONSHIP (1979) (11)
Interferon induction by poly(inosinic acid).poly(cytidylic acid) segmented by spin-labels. (1981) (11)
The synthesis and properties of some 5-substituted uracil derivatives. (1980) (11)
Combination Therapy of AIDS (2012) (11)
Synthesis and Antiviral Activity of 2 and 3-Substituted Imidazo[1,2-a]pyrimidine (1995) (11)
Palladium‐Catalyzed Aryl Amination Reactions of 6‐Bromo‐ and 6‐Chloropurine Nucleosides (2010) (11)
Synthesis and Antitumor Properties of Some Neutral Triesters of 5-Fluoro-2′-deoxyuridine-5′-monophosphate and 3′,5′-Cyclic Monophosphate (1995) (11)
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. (1999) (11)
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. (2000) (11)
Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3-N-methyl-thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole- (1993) (11)
The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level. (2003) (10)
Synthesis and antiviral activity of novel (2006) (10)
Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase. (2001) (10)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile (2nd Edition): Retroviruses and Hepadnaviruses (2008) (10)
Synthesis of 1,2-annulated adamantane heterocycles : structural determination studies of a bioactive cyclic sulfite (2009) (10)
Synthesis of some heterocycle containing urea derivatives and their anti-viral activity (2006) (10)
Inactivation of S-adenosyl-L-homocysteine hydrolase with novel 5'-thioadenosine derivatives. Antiviral effects. (2003) (10)
Mutagenic potential of anti-herpes agents. (1986) (10)
Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Non‐steroidal Anti‐inflammatory Drugs (2009) (10)
Synthesis and Biological Activities of C (5)-N-Spin-Labeled Uridines and Related Derivatives† (1983) (10)
Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-did (1998) (10)
Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells. (1989) (10)
Antihiv and antibacterial activities of 2-substituted thiadiazolo quinazolines (2003) (10)
Curious Discoveries in Antiviral Drug Development: The Role of Serendipity (2015) (10)
Transplacental Antiretroviral Therapy with 9-(2‐Phosphonylmethoxyethyl)adenine Is Embryotoxic in Transgenic Mice (1991) (10)
Role of purine N-3 in the biologic activities of poly(A) and poly(I). (1976) (10)
Baculovirus replication: inhibition of Trichoplusia ni multiple nuclear polyhedrosis virus by [E]-5-(2-bromovinyl)-2'-deoxyuridine. (1983) (10)
Side-chain derivatives of biologically active nucleosides. 1. Side-chain analogs of 3'-azido-3'-deoxythymidine (AZT). (1992) (10)
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF (Z) AND (E) α-ETHENYL ACYCLONUCLEOSIDES (2001) (10)
Synthesis of some novel thiosemicarbazone derivatives having anti-cancer, anti-HIV as well as anti-bacterial activity (2013) (10)
Herpes simplex acyclovir-resistant mutant in experimental keratouveitis. (1983) (10)
Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation. (1992) (10)
Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes (2010) (10)
Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes. (1985) (10)
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives. (2001) (10)
Synthesis and Biological Properties of (+) and (-)-(E)-5-(2-bronovinyl)-21 -deoxy-11 a-Carbauridine (1989) (10)
Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors. (2021) (10)
Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers. (2010) (10)
Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine. (1997) (10)
Synthesis of novel biologically active methylene derivatives of sydnones (2013) (10)
The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil. (2001) (10)
SYNTHESIS AND ANTIVIRAL PROPERTIES OF 5-VINYLPYRIMIDINE NUCLEOSIDE ANALOGS (1985) (10)
Thiosugars. Part 5: synthesis and biological activity of 1-(4-thio-L-arabinofuranosyl)-5-halopyrimidine nucleosides. (2000) (10)
Ovine Skin Organotypic Cultures Applied to the Ex vivo Study of Orf Virus Infection (2005) (10)
Renaturation of inactivated interferons: requirement for reduction of a major component; lack of requirement for reduction of a minor component. (1974) (10)
Mechanism of the Antiviral Activity Resulting from Sequential Administration of Complementary Homopolyribonucleotides to Cell Cultures (1972) (10)
Influence of various experimental conditions on the inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on varicella-zoster virus replication in cell culture. (1984) (10)
The HIV-1 non-nucleoside reverse transcriptase inhibitors (part V): capravirine and its analogues. (2012) (10)
Inhibition and reversal of the degradation of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo (1985) (10)
Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives. (2003) (10)
Chemoenzymatic Syntheses of Homo‐ and Heterodimers of AZT and d4T, and Evaluation of Their Anti‐HIV Activity (2004) (10)
Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine. (2018) (10)
Design, synthesis and biological evaluation of N2,N4-disubstituted-1,1,3-trioxo-2H,4H-pyrrolo[1,2-b][1,2,4,6]thiatriazine derivatives as HIV-1 NNRTIs. (2013) (10)
Design, synthesis, and biological evaluation of piperidinyl‐substituted [1,2,4]triazolo[1,5‐a]pyrimidine derivatives as potential anti‐HIV‐1 agents with reduced cytotoxicity (2020) (10)
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies. (2013) (10)
Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring (1999) (10)
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TlBO) derivatives. 4. (1995) (10)
Discovery of potent HIV‐1 non‐nucleoside reverse transcriptase inhibitors by exploring the structure–activity relationship of solvent‐exposed regions I (2019) (10)
GS-9190, a novel substituted imidazo-pyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug-resistant mutants (2007) (10)
Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections. (1996) (10)
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates. (1986) (10)
Synthesis and Fluorescent Properties of 6-(4-Biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine Analogues of Acyclovir and Ganciclovir (2003) (10)
η6-(Arene)tricarbonylchromium and Manganese Complexes Linked to 2‘-Deoxyuridine (2007) (10)
Comparative Anti-Retrovirus and Anti-Hepadnavirus Activity of Three Different Classes of Nucleoside Phosphonate Derivatives (1994) (10)
Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene. (1986) (10)
Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation. (1999) (10)
Alpba-Oligodeoxynucleotides as Inhibitors of HIV Reverse Transcriptase (1989) (10)
Phosphoramidates as Potent Prodrugs of anti-HIV Nucleotides: Studies in the Amino Region (1996) (10)
Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs. (2000) (10)
Synthesis and antiproliferative activity of 2′-O-allyl-1-β-D-arabinofuranosyl-uracil, -cytosine and -adenine (1997) (10)
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs). (2008) (10)
Antiviral activity of carbopol, a cross-linked polycarboxylate (2005) (9)
The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2. (2018) (9)
Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine (1995) (9)
Mannose-specific plant lectins are potent inhibitors of coronavirus infection including the virus causing SARS (2004) (9)
Inhibition of murine leukaemia virus reverse transcriptase by 2-halogenated polyadenylic acids. (1982) (9)
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties. (2020) (9)
Synthesis and Anti-HIV Activity of Dideoxycytidine Analogues Containing a Pyranose Carbohydrate Moiety (1991) (9)
Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents. (2009) (9)
Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one (2007) (9)
Nitroimidazoles Part 6. Synthesis, Structure and in Vitro anti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives (2007) (9)
In vitro Sensitivity of Kaposi's Sarcoma Cells to Various Chemotherapeutic Agents Including Acyclic Nucleoside Phosphonates (1999) (9)
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures. (1995) (9)
Curious discoveries in antiviral drug development: the role of serendipity. (2015) (9)
Interferon Induction by Nucleic Acids: Structure-Activity Relationships (1984) (9)
The nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors in the treatment of HIV infections (AIDS). (2013) (9)
Synthesis, Biological Activity, Pharmacokinetic Properties and Molecular Modelling Studies of Novel 1H,3H-Oxazolo[3,4-a]Benzimidazoles: Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors (2001) (9)
Synthesis and cytostatic activity of geiparvarin analogues. (1989) (9)
CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells (2000) (9)
Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines (1985) (9)
Dodecanucleotides Containing (E)-5-(2-Bromovinyl)-2′-Deoxyuridine: Influence of a Bulky Major Groove Substituent on Duplex Stability and Endodeoxyribonuclease Eco Ri Recognition (1988) (9)
A Review of its Pharmacodynamic and Pharmacokinetic Properties and Clinical Potential in HIV Infection (1996) (9)
Synthèses, activités biologiques et étude conformationnelle d'alcynyl-5 désoxy-2' uridines (1985) (9)
Phosphoramidate Derivatives of Stavudine as Inhibitors of HIV: Unnatural Amino Acids May Substitute for Alanine (2000) (9)
Bromovinyldeoxyurdine treatment of outer retinal necrosis due to varicella-zoster virus: a case-report. (1996) (9)
Anticonvulsant phenytoinergic pharmacophores and anti-HIV activity--preliminary evidence for the dual requirement of the 4-aminophthalimide platform and the N-(1-adamantyl) substitution for antiviral properties. (1998) (9)
Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene. (1985) (9)
Synthesis and Antiviral Activity of 1,2-Carbonucleosides (1995) (9)
Broad-Spectrum Antiviral Activity of 3′-Deoxy-3′-Fluoroadenosine against Emerging Flaviviruses (2020) (9)
Serum and urine concentrations of oral bromovinyldeoxyuridine in humans as monitored by a bioassay system based on varicella‐zoster virus focus inhibition (1987) (9)
The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides. (2000) (9)
Synthesis and Biological Evaluation of 4-Carbamoyl-2-β-D-Ribofuranosyl-Pyridine (1991) (9)
Dancing with chemical formulae of antivirals: A panoramic view (Part 2). (2013) (9)
New 3′-Azido-3′-deoxythymidin-5′-yl O-(ω-Hydroxyalkyl) Carbonate Prodrugs: Synthesis and Anti-HIV Evaluation. (2001) (9)
Synthesis and Biological Evaluation of 2-Carbamoyl-5-D-Ribofuranosylpyridine (1989) (9)
Gliotoxin analogues as inhibitors of reverse transcriptase. 1. Effect of lipophilicity. (1978) (9)
Antiviral Activity of Polyribocytidylic Acid in Cells Primed with Polyriboinosinic Acid (1971) (9)
Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation. (1999) (9)
HIV-1-specific reverse transcriptase inhibitors (1995) (9)
Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases. (1984) (9)
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19 (2022) (9)
SYNTHESIS OF AMINO ACIDS WITH MODIFIED PRINCIPAL PROPERTIES. III: SULFUR-CONTAINING AMINO ACIDS (1994) (9)
SYNTHESIS AND ANTI-HIV ACTIVITY OF THYMIDINE ANALOGUES BEARING A 4′-CYANOVINYL GROUP AND SOME DERIVATIVES THEREOF (2001) (9)
A guided tour through the antiviral drug field (2006) (9)
Towards an Effective Chemotherapy of Virus Infections: Therapeutic Potential of Cidofovir [(S)‐1‐[3‐Hydroxy‐2‐(phosphonomethoxy)propyl]cytosine, HPMPC] for the Treatment of DNA Virus Infections. (1998) (9)
Eco-friendly synthesis and biological evaluation of new quinoline-based dialkyl alpha-aminophosphonates (2007) (9)
Effect of chlorite-oxidized oxyamylose on Moloney sarcoma virus-induced tumor formation in mice. (1972) (9)
Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues. (1998) (9)
In vitro evaluation of the effect of temporary removal of HIV drug pressure. (2000) (9)
2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent. (1989) (9)
Novel carbocyclic nucleosides containing a cyclobutyl ring: adenosine analogues. (2001) (9)
The Holý Trinity: the acyclic nucleoside phosphonates. (2013) (9)
Design and development of curcumin bioconjugates as antiviral agents. (2008) (9)
Antiviral activity of a chemically stabilized 2‐5A analog upon microinjection into HeLa cells (1986) (9)
Synthesis, Antiviral and Cytotoxic Activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one Derivatives (2010) (9)
Synthesis, Antiviral and Cytotoxicity Studies of Novel N-substituted Indophenazine Derivatives (2012) (9)
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase. (2019) (9)
Basic approaches to anti-retroviral treatment. (1991) (9)
Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2′,3′-Dideoxynucleosides (1989) (9)
Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. (2020) (9)
Synthesis of 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine and Its Interaction with the HSV‐1 Thymidine Kinase (1996) (9)
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. (2009) (9)
Antitrypanosomal activity of phosphonylmethoxyalkylpurines. (1994) (9)
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides (1984) (9)
Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides (1996) (9)
Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs. (2021) (9)
Incorporation of (E)-5-(2-iodovinyl)-2'-deoxyuridine into deoxyribonucleic acids of varicella-zoster virus (TK+ and TK- strains)-infected cells. (1987) (9)
Failure of duplexes based on polylaurusin (poly(L), "Polyformycin B") to induce interferon. (1975) (9)
Chemo‐Enzymatic Synthesis of 3‐Deoxy‐β‐D‐ribofuranosyl Purines (2002) (9)
Cyclic Saligenyl Phosphotriesters of 2′,3′-Dideoxy-2′,3′- didehydrothymidine (d4T) - A New Pro-Nucleotide Approach. (1997) (9)
An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014. (2015) (9)
Synthesis of 5-(4-hydroxy-3-methylphenyl)-5-(substituted phenyl)-4, 5-dihydro-1H-1-pyrazolyl-4-pyridylmethanone derivatives with anti-viral activity (2007) (9)
Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides (2009) (9)
Ribavirin for HIV (1991) (9)
Synthesis and Antiviral Activity of 6-Benzoyl-Benzoxazolin-2-One and 6-Benzoyl-Benzothiazolin-2-One Derivatives (1999) (9)
The Thiocarboxanilides UC-10 and UC-781 Have an Additive Inhibitory Effect against Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Replication in Cell Culture When Combined with other Antiretroviral Drugs (1997) (9)
Therapeutic potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) as an antiviral drug (1994) (9)
Retroviral restriction factors TRIM5α: therapeutic strategy to inhibit HIV-1 replication. (2011) (9)
SYNTHESIS AND ANTIVIRAL ACTIVITY OF THE CARBOCYCLIC ANALOGS OF (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYURIDINES AND (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYCYTIDINES (1985) (9)
Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach (1997) (9)
Abatement of cutaneous Kaposi's sarcoma associated with cidofovir treatment. (1998) (9)
5-Nitro-2'-deoxyuridine 5'-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase. (1978) (9)
Mutations in Both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology (2005) (8)
Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers (1999) (8)
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro (1990) (8)
The Emerging Role of Fusion Inhibitors in HIV Infection (1999) (8)
Synthesis and anti-HIV evaluation of new 2-Thioxoimidazolidin-4-ones and their Arylidine (styryl) derivatives (2012) (8)
5'-O-Alkyl-5-fluorouridines: synthesis and biological activity (1987) (8)
Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection. (1998) (8)
Combined antiviral effects of acyclovir or bromovinyldeoxyuridine and human immunoglobulin in herpes simplex virus-infected mice. (1987) (8)
CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA. (1999) (8)
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel. (2021) (8)
Effects of topical and subconjunctival cidofovir (HPMPC) in an animal model. (1998) (8)
Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues. (2007) (8)
Triple-helical polynucleotides. Mixed triplexes of the poly(uridylic acid)-poly(adenylic acid)-poly(uridylic acid) class. (1976) (8)
Comparative evaluation of BVDU ((E)-5-(2-bromovinyl)-2'-deoxyuridine) in the treatment of experimental herpes simplex keratitis in rabbits. (1979) (8)
Comparison of the Disposition of Ester Prodrugs of the Antiviral Agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 Monolayers (1998) (8)
Oral Bromovinyldeoxyuridine Treatment of Herpes Zoster Ophthalmicus (1985) (8)
Synthesis and Antiviral Activity of a Series of New Cyclohexenyl Nucleosides (2003) (8)
Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus. (1968) (8)
Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides (2004) (8)
Chemotherapy of human immunodeficiency virus (HIV) infection: anti-HIV agents targeted at early stages in the virus replicative cycle. (1996) (8)
Synthesis and antiviral evaluation of pyridine fused heterocyclic and nucleosidic derivatives (1997) (8)
Non‐nucleoside HIV Reverse Transcriptase Inhibitors, Part 6[1]: Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues (2005) (8)
Synthesis and Biological Activity of C-Acyclic Nucleosides of Imidazo [1,5-a]-1,3,5-Triazines (1987) (8)
3-Cyclopentyl-1-adamantanamines and adamantanemethanamines. Antiviral activity evaluation and convulsions studies. (1994) (8)
Inhibition of tubulin polymerization by select alkenyldiarylmethanes. (2008) (8)
Metabolic and Pharmacological Characteristics of the Bicyclic Nucleoside Analogues (BCNAs) as Highly Selective Inhibitors of Varicella-Zoster Virus (VZV) (2003) (8)
Kinetics and distribution of interferon mRNA in interferon-primed and unprimed mouse L-929 cells. (1980) (8)
Inhibition of HIV-1-Induced Cytopathogenicity, Syncytium Formation, and Virus-Cell Binding by Naphthalenedisulphonic Acids through Interaction with the Viral Envelope gp120 Glycoprotein (1993) (8)
Using molecular symmetry to form new drugs: hydroxymethyl-substituted 3,9-diazatetraasteranes as the first class of symmetric MDR modulators. (2002) (8)
Nucleosides. Part 6. New chemical modification of the ribosyl moiety in uridines; synthesis of 2,2′-anhydro-1-[5-deoxy-5-(substituted thio)-β-D-arabinofuranosyl]uracil derivatives and their conversion into 3′,5′-epithiopyrimidine nucleosides (1988) (8)
BICYCLIC FURO PYRIMIDINE NUCLEOSIDES WITH ARYLOXYPHENYL AND HALOPHENYL SUBSTITUTED SIDE CHAINS AS POTENT AND SELECTIVE VARICELLA-ZOSTER VIRUS INHIBITORS (2001) (8)
Antiviral activity of 5-thiocyanatopyrimidine nucleosides. (1975) (8)
Antiviral Metal Complexes (1997) (8)
Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir. (2007) (8)
Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues. (2003) (8)
An Epimer of 5′-Noraristeromycin and Its Antiviral Properties. (1994) (8)
Discovery of novel pyridazinylthioacetamides as potent HIV-1 NNRTIs using a structure-based bioisosterism approach (2013) (8)
Potential of bromovinyldeoxyuridine in anticancer chemotherapy. (1986) (8)
Role of thymidine kinase and thymidylate synthetase in the cytostatic, antimetabolic, and antitumor effects of the carbocyclic analogue of 5-nitro-2'-deoxyuridine. A comparison with 5-nitro-2'-deoxyuridine. (1985) (8)
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on several parameters of Epstein-Barr virus infection. (1984) (8)
(E)-5-(2-bromovinyl)uridine requires phosphorylation by the herpes simplex virus (type 1)-induced thymidine kinase to express its antiviral activity. (1989) (8)
Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus: Synthesis and Biological Evaluation of 2′,3′-Dideoxy- 3′-fluoro and 2′-Deoxy-xylo Derivatives (2003) (8)
Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity. (1993) (8)
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. (2003) (8)
Phenotypic Resistance of Herpes Simplex Virus Type 1 Strains Selected in Vitro with Antiviral Compounds and Combinations Thereof (1996) (8)
(D)- AND (L)-CYCLOHEXENYL-G, A NEW CLASS OF ANTIVIRAL AGENTS: SYNTHESIS, CONFORMATIONAL ANALYSIS, MOLECULAR MODELING, AND BIOLOGICAL ACTIVITY (2001) (8)
Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors. (2014) (8)
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro (1996) (8)
2',3'-Dideoxynucleoside analogues as anti-HIV agents (1993) (8)
Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2020) (8)
Chemotherapy of respiratory syncytial virus infections: the final breakthrough. (2015) (8)
Synthesis of Novel AZA-Analogues of Tiazofurin with 2-[5,5-bis(Hydroxymethyl)Pyrrolidin-2-yl] Framework as Sugar Mimic (2012) (8)
Synthesis and Antiviral Evaluation of Some 3′‐Fluoro Bicyclic Nucleoside Analogues (2004) (8)
Antiviral drug sensitivity in ocular herpes simplex virus infection. (1990) (8)
Synthesis and anti-HIV activity of some isatin derivatives. (2001) (8)
Polynucleotide displacement reactions: detection by interferon induction. (1976) (8)
Antiviral effect of plant compounds of the Alliaceae family against the SARS coronavirus (2004) (8)
Antiviral activity of S-adenosylhomocysteine hydrolase inhibitors against plant viruses. (1990) (8)
Host Defense Mechanisms Against Murine Cytomegalovirus Infection Induced by Poly l:C in Severe Combined Immune Deficient (SCID) Mice (1994) (8)
Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV (2007) (8)
An ocular model of Adenovirus type 5 infection in the rabbit. (1995) (8)
Incorporation of the carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate into a synthetic DNA. (1987) (8)
The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure (1995) (8)
Cytotoxic Mannich Bases of 1-Arylidene-2-tetralones (2003) (8)
Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. (2019) (8)
In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine against newly isolated clinical varicella-zoster viras strains (1987) (8)
Isothiazole Derivatives as Antiviral Agents (2007) (8)
Biochemical pharmacology of nucleoside analogues active against HIV (1994) (8)
Trends in drug development for the treatment of AIDS compounds interfering with the initial stages of the HIV replicative cycle (1994) (8)
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV). (2007) (8)
Protective activity of the lipid A analogue GLA-60 against murine cytomegalovirus infection in immunodeficient mice. (1993) (8)
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity. (1996) (8)
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs (2020) (8)
Synthesis of acyclic 6,7-dihaloquinolone nucleoside analogues as potential antibacterial and antiviral agents. (2000) (8)
Control of RNA initiation and elongation at the HIV-I promoter (2000) (8)
Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleoside Analogues (2004) (8)
Guanosine analogues as anti-herpesvirus agents. (2000) (8)
Synthesis of 3'-azido-2',3'-dideoxy-6-methyluridine, 2',3'-dideoxy-6-methyluridine and 2',3'-dideoxy-2',3'-didehydro-6-methyluridine (1990) (8)
Non‐Nucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 10 (2008) (8)
Corrections to “Viologen” Dendrimers as Antiviral Agents: The Effect of Charge Number and Distance (2010) (8)
A Methylated Derivative of 5‘-Noraristeromycin (1997) (8)
DIARYL AMIDINE DERIVATIVES AS ONCORNAVIRAL DNA POLYMERASE INHIBITORS (1980) (8)
Improved and Rapid Synthesis of New Coumarinyl Chalcone Derivatives and Their Antiviral Activity. (2008) (8)
A more sensitive assay system for the detection of RNA-dependent DNA polymerase in oncogenic RNA viruses. (1973) (8)
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2. (1991) (8)
Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles. (2021) (7)
Anti-Picornavirus Activity and Other Antiviral Activity of Sulfated Exopolysaccharide from the Marine Microalga Gyrodinium impudicum Strain KG03 (2009) (7)
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA). (1998) (7)
Tanovea® for the treatment of lymphoma in dogs. (2018) (7)
An Odyssey in antiviral drug development—50 years at the Rega Institute: 1964–2014 (2015) (7)
X4 HIV-1 induces neuroblastoma cell death by interference with CXCL12/CXCR4 interaction. (2003) (7)
Preparation of Some Acetylated Deoxy-pento- and -hexofuranoses and their Deacetylation. (1994) (7)
SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS (2001) (7)
Antiviral Drug Strategies: DE CLERCQ:ANTIVIRAL DRUGS (2011) (7)
Inhibitory effects of several antiviral compounds on the replication of respiratory syncytial virus in vitro. (1985) (7)
Human cytomegalovirus (HCMV) strains selected under selective pressure of phosphonoformate (PFA) are resistant for both PFA and phosphonylmethoxyethyl (PME) derivatives in vitro (1995) (7)
3'-fluoro-azido-substituted and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside derivatives are potent anti-retrovirus agents (1988) (7)
TSAO-T Analogues Bearing Amino Acids at Position N-3 of Thymine: Synthesis and Anti-Human Immunodeficiency Virus Activity (2000) (7)
Inhibition of the degradation of thymine and 5-substituted uracil analogues by (E)-5-(2-bromovinyl)uracil in vivo (1985) (7)
Differential inhibitory effects of Evans blue on various DNA polymerases. (1986) (7)
Anthracyclinones. Part 1. A versatile synthesis of the anthracyclinone system using a chiral template derived from a carbohydrate (1983) (7)
Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus Modified on the Sugar Moiety: 3′ and 5′ Derivatives (2004) (7)
Antiviral activity of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine (1982) (7)
Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis. (1998) (7)
Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction. (2013) (7)
Novel TSAO derivatives modified at positions 3" and 4" of the spiro moiety. (1999) (7)
Synthesis, DNA binding and biological activity of oxazolopyridocarbazole-netropsin hybrid molecules (1991) (7)
Synthesis, Structural Studies, and Biological Evaluation of Some Purine Substituted 1-Aminocyclopropane-1-carboxylic Acids and 1-Amino-1-hydroxymethylcyclopropanes (2003) (7)
Assessment of the in vitro broad‐spectrum antiviral activity of some selected antitumor metallocene and metallocenium complexes (1989) (7)
Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine. (2006) (7)
Definitive Solution Structures for the 6-Formylated Versions of 1-(βD-Ribofuranosyl)-, 1-(2′-Deoxy-β-D-Ribofuranosyl)-, and 1-β-D-Arabinofuranosyluracil, and of Thymidine (1996) (7)
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication. (1992) (7)
Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT (2005) (7)
Design, Synthesis, and Biological Evaluation of Novel 2‐(Pyridin‐3‐yloxy)acetamide Derivatives as Potential Anti‐HIV‐1 Agents (2016) (7)
Absence of infectious retinitis after injection of human cytomegalovirus into rabbit eyes. (1995) (7)
Ac2IDU, BVDU, and thymine arabinoside therapy in experimental herpes keratitis. (1981) (7)
Current treatment of hepatitis B virus infections. (2015) (7)
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound. (2008) (7)
Local Shwartzman Phenomenon in Athymic Nude Mice (1980) (7)
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent. (1989) (7)
Discovery of a Tat HIV-1 Inhibitor through Computer-Aided Drug Design (2003) (7)
Acyclic nucleoside and nucleotide analogues derived from 1-deaza and 3-deazaadenine (1990) (7)
E-5-(2-Chlorovinyl)-2′-Deoxycytidine: Synthesis and Antiherpetic Activity (1990) (7)
Coumermycin A1 is a potent inhibitor of human immunodeficiency virus (HIV) replication in vitro (1989) (7)
HIV-1 gp 120 and chemokines activate ion channels in primary macrophages through CCR 5 and CXCR 4 stimulation (2000) (7)
Monitoring drug resistance for herpesviruses. (2000) (7)
Corrigendum to “Selective inhibition of hepatitis B virus replication by RNA interference” [Biochem. Biophys. Res. Commun. 309 (2003) 482–484] (2005) (7)
Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility. (2020) (7)
Synthesis, Protonation Behavior, Conformational Analysis, and Regioselective Enzymatic Acylation of the Novel Diamino Analogue of (E)-5-(2-Bromovinyl)-2′-deoxyuridine (BVDU) (2003) (7)
BVDU ((E)-5-(2-Bromovinyl)-2’-Deoxyuridine) (1984) (7)
Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate. (1999) (7)
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. (2021) (7)
Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-aza-neplanocin analogues. Synthesis and antiviral activity (1993) (7)
Preliminary report of anti-hepatitis C virus activity of chloroquine and hydroxychloroquine in huh-5-2 cell line (2006) (7)
Carbocyclic 7-Deazaguanine Oxetanocin Analogues (1998) (7)
Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine. (2008) (7)
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME ACYCLIC α-(1H-PYRAZOLO[3,4-d]PYRIMIDIN-4-YL)THIOALKYLAMIDE NUCLEOSIDES (2002) (7)
Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds. (1986) (7)
Chemical modification of antibiotic streptonigrin; synthesis and properties of 2'-decarboxy-2'-aminostreptonigrin (streptonigrone-2'-imine). (1992) (7)
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives. (2007) (7)
CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes (2001) (7)
Synthesis, structure–activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs (2010) (7)
Synthesis of Acycloalkenyl Derivatives of Pyrimidines and Purines (1995) (7)
Perturbation of cytokine production by bone marrow stromal cells after cytomegalovirus infection (1993) (7)
Protective activity of lipid A analogue GLA‐60 against murine cytomegalovirus infection in mice (1993) (7)
Synthesis and Antiviral Activity of 3‐Subtituted Derivatives of 3,9‐ Dihydro‐9‐oxo‐5H‐imidazo(1,2‐a)purines, Tricyclic Analogues of Acyclovir, and Ganciclovir. (1991) (7)
Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes (2010) (7)
Dideoxynucleoside analogues as inhibitors of HIV replication (1990) (7)
Design, synthesis, conformational analysis and biological activities of purine-based 1,2-di-substituted carbocyclic nucleosides. (2000) (7)
Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors (2021) (7)
Antiviral Drug Discovery: Ten More Compounds, and Ten More Stories. Part B (2009) (7)
Synthesis and antiviral evaluation of several 6-(Methylene-carbomethoxy)pteridine-4,7(3H,8H)-diones (1999) (7)
Antiviral and antimetabolic activities of poly (7-deazaadenylic acid) and poly (7-deazainosinic acid). (1975) (7)
Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl (2007) (7)
Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring. (2021) (7)
A convenient synthesis of new purinyl-homo-carbonucleosides on a cyclopentane ring fused with pyridazine (2004) (7)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile 2006 (1st Edition) (2006) (7)
Facile preparation of 9-H-pyrimido [4,5-b] [1,4] diazepine derivatives from 4,5-diaminopyrimidines and ethyl pyruvate. (1994) (7)
Hamao Umezawa Memorial Award Lecture: "An Odyssey in the Viral Chemotherapy Field". (2001) (7)
Synthesis and Biological Evaluation of 2-(2-deoxy-d-erythro-pent-1-enofuranosyl)pyridine C-nucleosides (1991) (7)
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. (1991) (7)
Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations (2008) (7)
In vitro antiviral and cytotoxic screening of methanolic extract of Cassia auriculata flowers in HeLa, Vero, CRFK and HEL cell lines (2013) (7)
Synthesis and Anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo‐[4,5‐e][1,2]thiadiazines (2008) (7)
Analogues of Acyclic Nucleosides Derived from Tris-(Hydroxymethyl)Phosphine Oxide or Bis-(Hydroxymethyl)Phosphinic Acid Coupled to DNA Nucleobases (2004) (7)
Evaluating phenotype and genotype of drug-resistant strains in herpesviruses (2001) (7)
Dancing with chemical formulae of antivirals: a personal account. (2013) (7)
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside. (1990) (7)
Antiviral Activity of N4-Aminocytidine Derivatives Related to AZT (1995) (7)
Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus (VZV): Pd-Catalysed Synthesis of 5-aryl Derivatives and Their Biological Evaluation (2001) (7)
Synthesis of aza-analogues of Ganciclovir (2006) (7)
Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells. (1983) (6)
Relative Potencies ofDifferent Anti-Herpes Agents inthe Topical Treatment ofCutaneous Herpes Simplex Virus Infection ofAthymic NudeMice (1979) (6)
Synthesis of 5-(1-substituted ethyl)uracil derivatives and some of their chemical and biological properties (1987) (6)
Anti-complement activity of polynucleotides. (1975) (6)
Interferon induction by mismatched analogues of polyinosinic acid . polycytidylic acid [(Ix,U)n.(C)n]. (1979) (6)
Identification of Novel Non-nucleoside Reverse Transcriptase Inhibitors Using Fragment-based Lead Generation (2005) (6)
Side-Chain Derivatives of Biologically Active Nucleosides. Part 2: Synthesis and anti-HIV Activity of 5′-C-Methyl Derivatives of 3′-Fluoro-3′-Deoxythymidine (1996) (6)
Heterocyclic rimantadine analogues with antiviral activity. (2003) (6)
Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors (2020) (6)
Synthesis and Antiviral Activity of Some C2-, C4-, and C6-Substituted Pyrazolo[3,4-D]Pyrimidine Acyclonucleosides with the Alkylating Chains of ACV, HBG, and ISO-DHPG (2006) (6)
Molecular simulation of 5,6-substituted 1-[(2-hydroxyethoxy)methyl]uracils with anti-HIV-1 activity (1996) (6)
Total syntheses of novel dideoxynucleoside analogues using chiral amino acids (2000) (6)
STUDIES ON S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE. PART V. SYNTHESIS AND ANTIVIRAL ACTIVITY OF STEREOISOMERIC ERITADENINES (1982) (6)
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile. (2006) (6)
Synthesis and Antiviral Activity of Acyclic Derivatives of 5‐Ethyl‐2′‐Deoxyuridine (1986) (6)
Synthesis, Solution Conformation and Biological properties of 2′,3′-Dideoxy-3′-fluoro-D-erythro-pentofuranosides of 2-Thiouracil and 2-Thiothymine (1995) (6)
Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase. (1991) (6)
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C. (2022) (6)
Synthesis and Biological Evaluation of a Series of Substituted Pyridine-C-Nucleosides. Part V: 3-Chloro-4-(D-Ribofuranosyl)Pyridine and 3-(D-Ribofuranosyl)-2-Pyridone (1989) (6)
Antiviral effects of dihydroxypropyladenine [RS)-DHPA) and bromovinyldeoxyuridine (BVDU) on plant viruses. (1987) (6)
Nucleoside Analogues Exerting Antiviral Activity Through a Non‐nucleoside Mechanism (2004) (6)
Ocular penetration and efficacy of chloroethyldeoxyuridine against herpetic keratouveitis. (1986) (6)
Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects. (2006) (6)
Potent inhibitory effects of the 5'-triphosphates of (E)-5-(2-bromovinyl)-2'-deoxyuridine and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil on DNA polymerase gamma. (1990) (6)
Synthesis and Antiviral Activity of Benzyl‐Substituted Imidazo(1,5‐a)‐ 1,3,5‐triazine (5,8‐Diaza‐7,9‐dideazapurine) Derivatives. (1995) (6)
Novel linked antiviral and antitumor agents related to netropsin - 2: Synthesis and biological evaluation (1991) (6)
Microwave-Assisted Synthesis and Anti-HIV Activity of New Acyclic C-Nucleosides of 3-(D-Ribo-Tetritol-1-yl)-5-Mercapto-1,2,4-Triazoles. Part 1 (2008) (6)
Mechanism of action of 5-(2-chloroethyl)-2'-deoxyuridine, a selective inhibitor of herpes simplex virus replication. (1990) (6)
Development of resistance of human immunodeficiency virus (HIV) to anti-HIV agents: how to prevent the problem? (1997) (6)
Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro (1992) (6)
Synthesis and antiviral activity of 3'-C-branched-3'-deoxy analogues of adenosine. (1996) (6)
Synthesis and evaluation of in vitro antiviral activity of 2-[3-(substituted phenyl)-4,5-dihydro-1H-5-pyrazolyl]benzofuran-3-yl chloride derivatives (2009) (6)
Synthesis and Biological Evaluation of Some D-Xylofuranosyl-Pyridine C-Nudeosides (1991) (6)
Some Hydrazones of 2‐Aroylamino‐3‐methylbutanohydrazide: Synthesis, Molecular Modeling Studies, and Identification as Stereoselective Inhibitors of HIV‐1 (2013) (6)
Resistance profile of human immunodeficiency virus to CADA, a novel HIV inhibitor that targets the cellular CD4 receptor (2005) (6)
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents. (1990) (6)
Synthesis of 3′-Fluoro-3′-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties (1989) (6)
Antiviral Activity of Heparin and Dextran Sulfate against Human Immunodeficiency Virus (HIV) in Vitro (1989) (6)
Synthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides (1997) (6)
Interferon: Ten Stories in One (2005) (6)
Acyclic and carbocyclic nucleoside analogues as inhibitors of HIV replication (1990) (6)
Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides (1997) (6)
Syntheses and Antiviral Activities of Some 5′‐O‐Acyl Derivatives (1984) (6)
The role of tenofovir in the prevention of HIV infections. (2006) (6)
Inhibition of Tumor Growth in Mice by Microwave Hyperthermia, Polyriboinosinic-Polyribocytidylic, and Mouse Interferon (1978) (6)
Synthesis and Preliminary Biologic Evaluation of 5‐Substituted‐2‐(4‐substituted phenyl)‐1,3‐Benzoxazoles as A Novel Class of Influenza Virus A Inhibitors (2012) (6)
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus / CD 4 cell receptor ( acquired immunodeficiency syndrome / flow cytometry (6)
Evaluation of Antiherpetic Compounds Using a Gastric Cancer Cell Line: Pronounced Activity of BVDU against Herpes Simplex Virus Replication (1996) (6)
Quinolone Nucleosides: 6,7-Dihalo-N-β- and α-Glycosyl-l 4-dihydro-4-oxo-quinoline-3-carboxylic Acids and Derivatives. Synthesis, Antimicrobial and Antiviral Activity (1998) (6)
New treatments for genital herpes (2002) (6)
SYNTHESIS AND BIOLOGICAL EVALUATION OF ISONUCLEOSIDES DERIVED FROM METHYL 3,5-ANHYDRO-2-O-(2-FLUOROBENZYL)-d-XYLOFURANOSIDES (2002) (6)
Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase (2014) (6)
Synthesis of Thymidine Analogues with a Cyanoimido Substituent (1991) (6)
Synthesis, antiviral and cytotoxic activities of some novel 2-Phenyl-3-Disubstituted Quinazolin-4(3H)-ones (2008) (6)
Brief Communication: Tumor Induction by Moloney Sarcoma Virus in Athymic Nude Mice (1975) (6)
The discovery of antiviral agents: Ten different compounds, ten different stories (2008) (6)
Discovery of Dihydro‐Alkyloxy‐Benzyl‐Oxopyrimidines as Promising Anti‐Influenza Virus Agents (2011) (6)
Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides. (2004) (6)
Therapy of poxvirus infections (2007) (6)
Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice. (1988) (6)
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis. (1990) (6)
Tumor induction by Moloney sarcoma virus in athymic nude mice. (1975) (6)
Increased resistance of trisomic-21 cells to virus replication: role of interferon. (1978) (6)
Tribute to John C. Martin at the Twentieth Anniversary of the Breakthrough of Tenofovir in the Treatment of HIV Infections (2021) (6)
A new method for the synthesis of 2-glycosylamino pyridines (1996) (6)
Synthesis of a Novel Class of Some 1 , 3 , 5-Triazine Derivatives and their Anti-HIV Activity (2010) (6)
Synthesis and Antiviral Evaluation of N-β-D-Ribosides of Ergot Alkaloids (1997) (6)
Hyporeactivity to Interferon Production by Double-Stranded RNA Associated with Hyporeactivity to Antiviral Protection and Hyporeactivity to Toxicity (1972) (6)
Human Brain Tumour Cell Lines as Cell Substrate to Demonstrate Sensitivity/Resistance of Herpes Simplex Virus Types 1 and 2 to Nucleoside Analogues (1994) (6)
Synthesis and Anti‐Myxovirus Activity of Some Novel N,N′‐Disubstituted Thioureas. (1994) (6)
INTERFERON: TEN STORIES IN ONE A SHORT REVIEW OF SOME OF THE HIGHLIGHTS IN THE HISTORY OF AN ALMOST QUINQUAGENARIAN* (2005) (6)
Synthesis and anti-HIV Evaluation of Alkyl and Alkoxyethyl Phosphodiester AZT Derivatives (1995) (6)
Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus: 5′-Chloro and 3′-Chloro Derivatives (2003) (6)
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5-fluorouracil against adenocarcinoma 755 in mice. Increased therapeutic index and correlation with increased plasma 5-fluorouracil levels. (1988) (6)
Design, Synthesis, and Biological Evaluation of Novel 3,5‐Disubstituted‐1,2,6‐Thiadiazine‐1,1‐Dione Derivatives as HIV‐1 NNRTIs (2013) (6)
The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of inosine monophosphate dehydrogenase (2005) (6)
Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy (2020) (6)
Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR 5 / CXCR 4 Antagonist (2004) (6)
2001 ASPET Otto Krayer Award Lecture. Molecular targets for antiviral agents. (2001) (5)
In search of a selective therapy of viral infections. (2010) (5)
New AZT Analogues Having 5′-Alkylsulfonyl Groups: Synthesis and Anti-HIV Activity (2007) (5)
Monoglycosyl, diglycosyl, and dinucleoside methylenediphosphonates: direct synthesis and antiviral activity. (2006) (5)
Increased resistance of trisomic-21 cells to virus replication: Role of interferon (1978) (5)
Chapter 1. Overview of Antiviral Drug Discovery and Development: Viral Versus Host Targets (2021) (5)
Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives. (2009) (5)
THIOSUGARS. VIII.* PREPARATION OF NEW 4′-THIO-L-LYXO PYRIMIDINE NUCLEOSIDE ANALOGUES (2001) (5)
Synthesis and Biological Evaluation of Some Acyclic 4,6-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine Nucleosides (2003) (5)
How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications (2004) (5)
Tenofovir at the Crossroad of the Therapy and Prophylaxis of HIV and HBV Infections (2020) (5)
Comparative Study of the Efficacy of Different Forms of Interferon Therapy in the Treatment of Mice Challenged Intranasally with Vesicular Stomatitis Virus (VSV) (1971) (5)
Chemo-enzymatic Synthesis of 3-Deoxy-β-D-ribofuranosyl Purines and Study of Their Biological Properties (2003) (5)
4″-H-TSAO-T, A NOVEL PROTOTYPE IN THE HIV-1 SPECIFIC TSAO FAMILY (2001) (5)
Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability. (2021) (5)
Biological, biochemical and physicochemical evidence for the existence of the polyadenylate - polyuridylate - poly 2'-fluoro-2'-deoxyuridylate triple-stranded complex. (1976) (5)
Synthesis and cytostatic properties of daunorubicin derivatives, containing N-phenylthiourea or N-ethylthiourea moieties in the 3'-position. (1991) (5)
Oral brivudin versus intravenous acyclovir in the treatment of herpes zoster in immunocompromised patients: a randomized double-blind trial (1995) (5)
CXCR4 Chemokine Receptor Antagonists from Ultra-rigid Metal Complexes Profoundly Inhibit HIV-1 Replication, and also AMD3100-resistant Strains (2009) (5)
Discovery and Development of Tenofovir Disoproxil Fumarate (2011) (5)
NOVEL ARYL SUBSTITUTED BICYCLIC FURO NUCLEOSIDES AS EXTREMELY POTENT AND SELECTIVE ANTI-VZV AGENTS (2001) (5)
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. (2008) (5)
Discovery, optimization, and target identification of novel coumarin derivatives as HIV-1 reverse transcriptase-associated ribonuclease H inhibitors. (2021) (5)
New developments in the chemotherapy of lentivirus (human immunodeficiency virus) infections: sensitivity/resistance of HIV-1 to non-nucleoside HIV-1-specific inhibitors. (1994) (5)
Therapy for herpesvirus infections (1991) (5)
Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes (2012) (5)
Inhibitory activity of vancomycin, eremomycin and teicoplanin aglycon derivatives against feline and human coronaviruses (i.e. SARS) (2004) (5)
Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues. (1999) (5)
Therapeutic Approaches to HHV-6 Infection (2006) (5)
Palladium-catalyzed synthesis of (E)-5-(2-acylvinyl)-2′-deoxyuridines and their antiviral and cytotoxic activities (1995) (5)
Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives (2003) (5)
Bicyclic Nucleoside Inhibitors of Varicella‐Zoster Virus (VZV): The Effect of a Terminal Halogen Substitution in the Side‐Chain. (2000) (5)
6-[2-(Phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity (2005) (5)
Fomivirsen: A Viewpoint by Erik de Clercq (1999) (5)
Antiviral Drug Targets and Strategies for Emerging Viral Diseases and Bioterrorism Threats (2005) (5)
Antiviral therapy: quo vadis? (2010) (5)
Anno 2021: Which antivirals for the coming decade? (2021) (5)
Antiherpes drugs: Promises and pitfalls (1984) (5)
Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet. (2004) (5)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile 2006 (1st edition): The RNA Viruses with DNA Intermediates (Retroviruses) (2006) (5)
Molecular Requirements for Synthetic RNA to Act in Interferon Stimulation (1971) (5)
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures (2010) (5)
Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) (1995) (5)
3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxyuridine. (1990) (5)
Synthesis of Novel 5″-Substituted Tsao-T Analogues with Anti-Hiv-1 Activity (2000) (5)
Phosphonates Derivatives of 2′,3′-Dideoxy-2′,3′-didehydro-pentopyranosyl Nucleosides (1995) (5)
Thiosugars. XII. Synthesis of New 3′‐O‐Substituted 2′,5′‐Anhydro‐2′‐thio‐α‐d‐pentofuranosyl Nucleoside Analogues (2004) (5)
In vitro and in vivo antiviral activity of 2'-fluorinated arabinosides of 5-(2-haloalkyl)uracil. (1987) (5)
Synthesis and biological properties of 2-amino-3-fluoro-2,3-dideoxy-D-pentofuranosides of natural heterocyclic bases (1991) (5)
Towards a selective chemotherapy of virus infections. Development of bromovinyldeoxyuridine as a highly potent and selective antiherpetic drug. (1986) (5)
Synthesis of 2′‐Aminomethyl Derivatives of N‐(2‐(Phosphonomethoxy) ethyl) Nucleotide Analogues as Potential Antiviral Agents. (1996) (5)
Strategies in the Design of Oligonucleotides as Potential Antiviral Agents (1984) (5)
Nucleoside analogues as antiviral agents. (1981) (5)
9-[ ( 2 RS )-3-Fluoro-2-phosphonylmethoxypropyl ] derivatives of purines : A class of highly selective antiretroviral agents in vitro and in vivo (5)
Polyadenylic-polyxanthylic-polyuridylic acid triple helix. (1977) (5)
Alkyloxyphenyl Furano Pyrimidines as Potent and Selective Anti-VZV Agents with Enhanced Water Solubility (2002) (5)
Anti-HIV activity of a series of cosalane amino acid conjugates. (2000) (5)
Antiviral activity of 2-phosphonomethoxyalkyl derivatives of N6-substituted 6-aminopurines (1995) (5)
HEPT: From an Investigation of Lithiation of Nucleosides Towards a Rational Design of Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1 (2000) (5)
Synthesis and anti-HIV-1 Activity of [1-[2′,5′-Bis-O-(Tert-Butyldimethylsilyl)-β-L-Ribofuranosyl]Thymine]-3′-Spiro-5″-(4″-Amino-1″,2″-Oxathiole-2″,2″-Dioxide) (L-TSAO-T), the L-enantiomer of the Highly Specific HIV-1 Reverse Transcriptase Inhibitor TSAO-T (1995) (5)
Synthesis and cytotoxic evaluation of some carbohydrazones and thiocarbohydrazones of various unsaturated ketones and related Mannich bases. (1997) (5)
Anti-HIV-1 Activity of Benzothiadiazine Dioxide (2001) (5)
Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides (2011) (5)
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket. (2021) (5)
Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective. (2009) (5)
Another ten stories in antiviral drug discovery (part C): “Old” and “new” antivirals, strategies, and perspectives (2009) (5)
Antiviral activity of O'-methylated derivatives of adenine arabinoside. (1977) (5)
Synthesis of New 2,3‐Diaryl‐1,3‐thiazolidin‐4‐ones and anti‐HIV Agents. (2004) (5)
Synthesis and anti-HIV properties of 1,2,4,6-thiatriazin-3-one 1,1-dioxide nucleosides. (1998) (5)
Synthesis of 6-Arylthio Analogs of 2′,3′-Dideoxy-3′-Fluoroguanosine and Their Effect against Hepatitis B Virus Replication (2006) (5)
2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation (1995) (5)
Role of Adenosine Kinase in the Biological (Antiviral and Anticellular) Activities of Adenosine Analogues (1987) (5)
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of tetrahydro-imidazo[4,5,1-JK][1,4]-benzzodiazepin-2(1H)-one and -thione (TIBO) derivatives (1990) (5)
N-3 Substituted TSAO Derivatives as a Probe to Explore the Dimeric Interface of HIV-1 Reverse Transcriptase (2003) (5)
Synthesis and Biological Evaluation of Some α-[6-(1′-Carbamoylalkylthio)-1 H-Pyrazolo[3,4-D]Pyrimidin-4-yl]Thioalkylcarboxamide Acyclonucleosides (2007) (5)
Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by exchange labelling. (1986) (5)
Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C. (2020) (5)
Antiviral activity of polynucleotides: poly 2′‐o‐ethyladenylic acid and poly 2′‐o‐ethyluridylic acid (1974) (5)
Incorporation of 5-substituted pyrimidine nucleoside analogues into DNA of a thymidylate synthetase-deficient murine FM3A carcinoma cell line. (1985) (5)
Immunochemical measurement of conformational heterogeneity of poly(inosinic acid). (1978) (5)
Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs. (2013) (5)
Synthesis and Biological Study of the Cyclopentenyl Carbocyclic Nucleoside Analogue of 5-Azacytidine (1992) (5)
Synthesis of [1-[2′,5′-bis-O-(t-Butyldimethylsilyl)-β- L-ribofuranosyl] thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (L-TSAO-T) (1995) (5)
Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent. (1988) (5)
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments. (2001) (5)
On the Mechanism of Anti-Herpes Action of E-5-(2-Bromovinyl)-2′-Deoxyuridine (1981) (5)
Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro (1983) (5)
Synthesis of penicillamine- and cysteine-containing nucleoamino acids as potential antivirals and aminopeptidase B inhibitors (1991) (5)
Halophenyl Furanopyrimidines as Potent and Selective Anti-VZV Agents (2003) (5)
Differential effects of E-5-(2-bromovinyl)-2'-deoxyuridine on infections with herpes simplex virus type 1 and type 2 in hairless mice. (1982) (5)
Synthesis, Antiviral and Cytotoxic Activities of SomeNovel 2,3-Disubstituted Quinazolin-4(3H)-Ones (2008) (5)
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-N-substituted-hydrazinecarbothioamides (2012) (5)
Preparation and biological properties of a highly active poly(G) X poly(C) inducer of interferon. (1984) (5)
Highly Potent and Selective Inhibition of Varicella—Zoster Virus Replication by Bicyclic Furo[2,3-d]pyrimidine Nucleoside Analogues (2003) (5)
Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian. (2005) (5)
Transplantation and Clinical Immunology XXIII (1991) (5)
Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues (1995) (5)
Nucleosides and Nucleotides. Part 148. New Neplanocin Analogues. Part 6. Synthesis and Potent Antiviral Activity of 6′-Homoneplanocin A. (1996) (5)
Synthesis and antiviral activity of acyclic nucleoside and nucleotide derivatives of 8-azaadenine (1993) (5)
Trends in the disease burden of HBV and HCV infection in China from 1990 to 2019. (2022) (5)
ALKYL ESTERS OF 3-ADENIN-9-YL-2-HYDROXYPROPANOIC ACID: A NEW CLASS OF BROAD-SPECTRUM ANTIVIRAL AGENTS (1985) (5)
Acyclic nucleoside phosphonates: a new dimension to the chemotherapy of DNA virus and retrovirus infections. (1998) (5)
SYNTHESIS AND IN VITRO EVALUATION OF NOVEL ANTI-VARICELLA-ZOSTER VIRUS (VZV) NUCLEOSIDES (2001) (5)
Virus-drug resistance: thymidine kinase-deficient (TK-) mutants of herpes simplex virus. Therapeutic approaches. (1987) (5)
The synthesis of novel 6-substituted acyclouridine derivatives which show specific inhibition of HIV-1 (1990) (4)
Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers (1987) (4)
Nucleic Acid Related Compounds. Part 51. Synthesis and Biological Properties of Sugar-Modified Analogues of the Nucleoside Antibiotics Tubercidin, Toyocamycin, Sangivamycin, and Formycin. (1987) (4)
Mechanism of interaction of sodium dodecyl sulfate with mouse interferon. (1979) (4)
Treatment (Bromovinyldeoxyuridine) of Herpetic Eye Infections (1988) (4)
An Approach towards the Synthesis of Potential Metal-Chelating TSAO-T Derivatives as Bidentate Inhibitors of Human Immunodeficiency virus Type 1 Reverse Transcriptase (1998) (4)
Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo. (2002) (4)
Antiviral Classification (2021) (4)
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof. (2003) (4)
Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors (2001) (4)
Novel Tsao Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues ‡ (1996) (4)
Mouse and hamster models for the study of therapy against flavivirus infections. (2006) (4)
Synthesis and Evaluation of 5-Halo 2′,3′-Didehydro-2′,3′-Dideoxynucleosides and their Blocked Phosphoramidates as Potential Anti-Human Immunodeficiency virus Agents: An Example of ‘Kinase Bypass’ (1997) (4)
Studies of Phase Equilibria in the System MgO--Mo--O in the Temperature Range 1100--1400 K. (1994) (4)
Synthesis and Antiviral Activity of 1.4-Dioxane, 1.4-Oxathiane and 1,4-Morpholine Nucleoside Analogues (1991) (4)
The Synthesis and Antiviral Activity of Some New S-Adenosyl-L-homocysteine Derivatives and Their Nucleoside Precursors (1995) (4)
Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region. (1999) (4)
Differential metabolism of (E)-5-(2-iodovinyl)-2'-deoxyuridine (IVDU) by equine herpesvirus type 1- and herpes simplex virus-infected cells. (1987) (4)
In vitro andin vivo inhibition of virus multiplication by microwave hyperthermia (2005) (4)
Anti-viral agents (1968) (4)
Substituted 5‐Benzyl‐2‐phenyl‐5H‐imidazo[4,5‐c]pyridines: A New Class of Pestivirus Inhibitors. (2007) (4)
Chemoenzymatic synthesis and antiviral evaluation of conformationally constrained and 3'-methyl-branched carbanucleosides using both enantiomers of the same building block. (2008) (4)
Herpesvirus infections in immunocompromised patients. (1995) (4)
Synthesis and antiviral properties of carbocyclic 3'-oxa-2',3'-dideoxyguanosine and its 7-deazaguanosine analogue. (1993) (4)
Chemotherapy of Viral Infections (1996) (4)
2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives (1994) (4)
Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile. (2017) (4)
AIDS in the Third World: how to stop the HIV infection? (2007) (4)
cyclo-Saligenyl-3′-azido-2′,3′-dideoxy-thymidinemonophosphate ( cycloSal-AZTMP) - A New Pro-Nucleotide Approach? (1997) (4)
Synthesis and anti-herpes activity of 5-trifluorovinyl-2'-deoxyuridine (1992) (4)
Inhibition of Human Immunodeficiency Virus Type (HIV-1) Replication by Some Diversely Functionalized Spirocyclopropyl Derivatives. (1999) (4)
CXCR4 Antagonists: A New Generation of Configurationally Restricted Bis-azamacrocyclic Compounds (2009) (4)
First Example of a 4-Amino-1,2,4,6-thiatriazine 1,1-Dioxide Derivative (1996) (4)
Synthesis of Some Novel Thiosemicarbazone Derivatives Having Anticancer, anti‐HIV as well as Antibacterial Activity. (2013) (4)
Strategies for the treatment of cytomegalovirus infections (1993) (4)
Synthesis and Anti-HIV Evaluation of 2′,3′-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2′,3′-Dideoxynucleosides. (1990) (4)
Synthesis And Comparative Cytostatic Activity Of The New N-7 Acyclic Purine Nucleoside Analogues With Natural N-9 Regioisomers (2005) (4)
Inactivation of S-Adenosyl-L-homocysteine Hydrolase with Novel 5′-Thioadenosine Derivatives. Antiviral Effects. (2003) (4)
Bromovinyluracil nucleoside analogues as antiherpes agents (1984) (4)
Synthesis of Purinyl homo-Carbonucleoside Derivatives of 2-Benzylcyclopenta[c]pyrazol (2005) (4)
Synthesis of Acyclo‐C‐nucleosides in the Imidazo(1,2‐a)pyridine and ‐ pyrimidine Series as Antiviral Agents. (1996) (4)
The 5'-monophosphates of 5-propyl- and 5-ethyl-2'-deoxyuridine do not inhibit the replication of deoxythymidine kinase deficient (TK-) mutants of herpes simplex virus. (1980) (4)
Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP. (2021) (4)
Sodium and potassium benzeneazophosphonate complexes with crown ethers: solid-state microwave synthesis, characterization and biological activity (2009) (4)
Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation (2003) (4)
Database Searching for Thymidine and Thymidylate Kinase Inhibitors Using Three-dimensional Structure-based Methods (2002) (4)
Intentional reactivation of latent ocular herpes infection during BVDU therapy. (1987) (4)
Prodrugs of 5‐Ethyl‐2′‐deoxyuridine, II Syntheses and Antiviral Activities of 5′‐ and 3′‐Ester Derivatives (1986) (4)
Synthesis and biological evaluation of 2-(2-deoxy-β-D-ribofuranosyl)pyridine-4-carboxamide (1992) (4)
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates. (2000) (4)
Potential Prodrug Derivatives of 2′,3′-Didehydro-2′,3′-dideoxynucleosides. Preparations and Antiviral Activities. (1992) (4)
Design, Synthesis, and Biological Evaluation of Novel 4‐Aminopiperidinyl‐linked 3,5‐Disubstituted‐1,2,6‐thiadiazine‐1,1‐dione Derivatives as HIV‐1 NNRTIs (2015) (4)
Organic Chemist Whose Inventions Reshaped the Antiviral Drug World (2013) (4)
d4TMP Delivery from 7-Substituted cycloSal-d4TMPs (2003) (4)
Human Cytomegalovirus Stimulates Thymidylate Synthase in Human Embryonic Lung Cells: A Possible Target for Anti-HCMV Therapy? (1995) (4)
In vitro cotranslational processing of human pre-interferon beta 1 enhances its biological activity. (1982) (4)
Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine (1995) (4)
Synthesis And Antimicrobial Activity Of Some Novel 6-Bromo-2-Methyl/phenyl-3-(Sulphonamido) quinazolin-4(3H)- Ones (2004) (4)
Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues (1997) (4)
Cytotoxicity and antiviral activity of palladium(II) quinolylmethylphosphonate complexes. Synthesis of acetate complexes (2006) (4)
Selective virus inhibitors. (1990) (4)
Novel approaches towards anti-HIV chemotherapy (1998) (4)
Molecular Targets of Chemotherapeutic Agents Against the Human Immunodeficiency Virus (1989) (4)
SYNTHESIS OF (E)-5-(3,3,3-TRIFLUORO-1-PROPENYL)-2′-DEOXYURIDINE AND RELATED ANALOGS: POTENT AND UNUSUALLY SELECTIVE ANTIVIRAL ACTIVITY OF (E)-5-(3,3,3-TRIFLUORO-1-PROPENYL)-2′-DEOXYRIDINE AGAINST HERPES SIMPLEX VIRUS TYPE 1 (1984) (4)
Inhibitory activity of diarylamidine derivatives on murine leukemia L1210 cell growth (2004) (4)
Studies on anti-HIV activity of Indigofera tinctoria (2000) (4)
Biologically Important Nucleosides: A General Method for the Synthesis of Unsaturated Ketonucleosides of Uracil and its Analogs (1991) (4)
The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4'-benzamido-2'-butenyl moiety: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations. (2010) (4)
Design and Synthesis of Regioisomeric Analogues of a Specific Anti‐HIV‐ 1 Agent 1‐((2‐Hydroxyethoxy)methyl)‐6‐(phenylthio)thymine (HEPT). (1995) (4)
Interferon production in rabbit kidney cell cultures exposed to poly (I). poly (C) adsorbed to rabbit red blood cells. (1974) (4)
New promising inhibitors of the human immunodeficiency virus (1989) (4)
DAUNORUBICIN DERIVATIVES OBTAINED FROM DAUNORUBICIN AND NUCLEOSIDE DIALDEHYDES (1997) (4)
New [4,5,1-JK][1,4]benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 and are synergistic with 2',3'-dideoxynucleoside analogs (1994) (4)
The Changing Face of Hepatitis C: Recent Advances on HCV Inhibitors Targeting NS5A (2015) (4)
Inhibitory Activity of (E)‐5‐(2‐Bromovinyl)‐2′‐Deoxyuridine on the Salmonid Herpesviruses, Oncorhynchus masou Virus (OMV) and Herpesvirus salmonis (1988) (4)
BENZYL-FUNCTIONALIZED cycloSal-d4T MONOPHOSPHATES (2001) (4)
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. (1988) (4)
Chemotherapy of the acquired immune deficiency syndrome (AIDS): non-nucleoside inhibitors of the human immunodeficiency virus type 1 reverse transcriptase. (1991) (4)
From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor (2011) (4)
Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety. (1997) (4)
Stereospecific Synthesis and Biological Evaluations of β‐L‐Pentofuranonucleoside Derivatives of 5‐Fluorouracil and 5‐Fluorocytosine. (2001) (4)
Synthesis and biological evaluation of some stilbene derivatives (2011) (4)
High Speed HPLC Determination of Bis(Pivaloyloxymethyl)-PMEA and Its Degradation Products, Mono(POM)-PMEA and PMEA (1996) (4)
Role of interferon in the protective effect of the double-stranded polyribonucleotide against murine tumors induced by Moloney sarcoma virus. (1971) (4)
How to overcome resistance of HIV-1 to HIV-1-specific reverse transcriptase inhibitors. (1994) (4)
Combination of azidothymidine (AZT) and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) inhibits the replication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella zoster virus (VZV) strains that are deficient in the expression of the viral thymidine kinase (TK) (1995) (4)
Biotransformation of 5-(2-chloroethyl)-2'-deoxyuridine in male NMRI mice. (1989) (4)
[Current acquisitions in antiviral drugs (anti-HIV)]. (1992) (4)
The interaction of polyxanthylic acid with polyadenylic acid. (1977) (4)
Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy. (1999) (4)
Differential inhibitory effects of sulfated polysaccharides on the replication of various myxo- and retroviruses (1991) (4)
Hyporeactivity to Interferon Production by Double-Stranded RNA Associated with Hyporeactivity to Antiviral Protection and Hyporeactivity to Toxicity (1972) (4)
Renaturation of inactivated interferons by "defensive reversible denaturation". (1974) (4)
Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity (2000) (4)
How to overcome resistance of HIV-1 to HIV-1-specific reverse transcriptase inhibitors. (1994) (4)
Interferon induction by platinum(II)-poly(I).poly(C) complexes. (1983) (4)
Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. (2022) (4)
Synthesis, Solution Conformation and Anti-HIV Activity of Novel 3-Substituted-2′,3′-Dideoxy-5-Hydroxymethyl-Uridines and Their 4,5-Substituted Analogues (2003) (4)
Synthesis and Biological Evaluation of Some D-Arabino- and D-Lyxofuranosyl-Pyridine C-Nucleosides (1994) (4)
Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action. (1983) (4)
Mechanism of Anti-HIV Action of Masked Alaninyl 2 ,3 -Dideoxy-2 ,3 -Didehydrothymidine 5 -Monophosphate Derivatives (1996) (4)
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma. (1998) (4)
NUCLEIC ACID RELATED COMPOUNDS. 40. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-ALKYNYLURACIL NUCLEOSIDES (1983) (4)
THE JOURNEY TOWARDS ELUCIDATING THE ANTI-HCMV ACTIVITY OF ALKYLATED BICYCLIC FURANO PYRIMIDINES (2005) (4)
Perspectives for the Treatment of Infections withFlaviviridae (2000) (4)
Mechanism of Antiviral Activity of 5-Ethyl-2′-Deoxyuridine (1987) (3)
Synthesis and Biological Properties of Some Cyclic Phosphotriesters Derived from 2′-Deoxy-5-fluorouridine. (1984) (3)
Synthesis and Antiviral Evaluation of New 4-Quinolone Acyclonucleosides. (1992) (3)
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. (2007) (3)
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo (1993) (3)
Synthesis and antiviral activity of some new benzofuran derivatives. (1993) (3)
Towards New Thymidine Phosphorylase/PD-ECGF Inhibitors Based on the Transition State of the Enzyme Reaction (2003) (3)
Increased oral absorption of the antiviral ester prodrug Tenofovir disoproxil in rat ileum (2000) (3)
Clinical Use of Antiviral Drugs (2012) (3)
Syntheses of 4‐[1‐(2‐Deoxy‐β‐D‐ribofuranosyl)] Derivatives of 2‐Substituted‐5‐fluoroaniline: “Cytosine Replacement” Analogues of Deoxycytidine for Evaluation as Anticancer and antihuman Immunodeficiency Virus (anti‐HIV) Agents. (2000) (3)
Thymidylate synthetase‐positive and ‐negative murine mammary FM3A carcinoma cells as a useful system for detecting thymidylate synthetase inhibitors (1984) (3)
Investigation of anti-HIV activity, cytotoxicity and HIV integrase inhibitory activity of polyherbal formulation BH extracts (2014) (3)
Interferon induction by polynucleotides: structure-function relationship. (1977) (3)
Development of antiviral drugs for the treatment of hepatitis C at an accelerating pace (2015) (3)
Substituted Imidazopyridines as Potent Inhibitors of Hepatitis C Virus Replication that Target the Viral Polymerase (2007) (3)
Preparation, spectral properties and biological activities of 5-bromo-6-methyl-2'-deoxyuridine and 5-iodo-6-methyl-2'-deoxyuridine (1980) (3)
The antiviral activity of 9-beta-D-arabinofuranosyladenine is enhanced by the 2',3'-dideoxyriboside, the 2',3'-didehydro-2',3'-dideoxyriboside and the 3'-azido-2',3'-dideoxyriboside of 2,6-diaminopurine. (1989) (3)
Baseline resistance is significantly associated with long-term therapy response, especially in non-adherent patients (2001) (3)
3′‐Fluoro‐ and 3′‐Azido‐Substituted 2′,3′‐Dideoxynucleosides: Structure‐Activity Relationship. (1991) (3)
Cidofovir: Induction of apoptosis in human papilloma virus (HPV)-containing cell lines (1997) (3)
Synthesis and anti‐HIV Activity of 2,3‐Diaryl‐1,3‐thiazolidin‐4‐(thi)one Derivatives. (2003) (3)
Cyclosaligenyl-2 9 , 3 9-didehydro-2 9 , 3 9-dideoxythymidine Monophosphate : Efficient Intracellular Delivery of d 4 TMP (2000) (3)
Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis. (2013) (3)
Stimulatory effects of antiviral adenosine analogs on steroidogenesis in Leydig cells. (1988) (3)
In vivo antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its cyclic form (2007) (3)
Interaction of polyriboinosinic acid, polyribocytidylic acid with human lymphoblastoid cells. (1980) (3)
Treatment of bovine leukaemia virus-infected sheep with suramin: an animal model for the development of antiretroviral compounds. (1989) (3)
Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability. (2022) (3)
Synthesis and anti‐HIV Activity of 1‐(2,6‐Difluorophenyl)‐1H,3H‐thiazolo[3,4‐a]benzimidazole Structurally‐Related 1,2‐Substituted Benzimidazoles. (2003) (3)
Synthesis of New Homo and Heterodimers of 2′,3′-Dideoxyinosine (ddi) Using Ester Linkages (2003) (3)
FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis? (2022) (3)
5-substituted arabinofuranosyluracil nucleosides: synthesis and antiviral properties. (1984) (3)
Synthesis of a potential photoaffinity labelling reagent for HIV-1 reverse transcriptase (1993) (3)
9-(1-Fluoro-5-hydroxypentan-2-yl)-9H-guanine: synthesis and evaluation of antiviral activity (1993) (3)
Effect of 2-Amino Substitution on the Antiviral Effects of 5-Ethyl-2′-Deoxyuridine and (E)-5-(2-bromovinyl)-2′-Deoxyuridine and Their Incorporation into DNA (1991) (3)
In Vivo Release of Previously Cleared Interferon by Cycloheximide (1972) (3)
Treatment of Visna Virus Infection in Lambs with the Acyclic Nucleoside Phosphonate Analogue 9-(2-Phosphonylmethoxyethyl)Adenine (PMEA) (1998) (3)
Synthesis and Antiviral Activity of 5′-Deoxypyrazofurin. (1994) (3)
Synthesis and Antiviral Activity Assay of Novel (E)-3′,5′-Diamino-5-(2-bromovinyl)-2′,3′,5′-trideoxyuridine (2003) (3)
Phenotypic assays and sequencing are less sensitive for the detection of resistance in mixed genotypes compared to point mutation assays (1998) (3)
Nitroimidazoles. Part 4. Synthesis and anti-HIV Activity of New 5-Alkylsulfanyl and 5-(4′-Arylsulfonyl)piperazinyl-4-nitroimidazole Derivatives. (2007) (3)
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine. (1990) (3)
Synthesis and cytostatic evaluation of some 2-(5-substituted-2-oxoindolin-3-ylidene)-N-substituted hydrazine carbothioamide (2011) (3)
3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues. (1999) (3)
The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins. (2009) (3)
SAR of alkyloxyphenyl furano pyrimidines: Potent and selective anti-VZV agents (2006) (3)
CC Chemokine Receptor 3 Human Eotaxin by Affecting Its Interaction Potency , But Not the Anti-HIV Activity of Down-Regulates the Eosinophil Chemotactic CD 26 / Dipeptidyl-Peptidase IV (1999) (3)
“SECOND GENERATION” OF TSAO COMPOUNDS DIRECTED AGAINST HIV-1 TSAO-RESISTANT STRAINS (2001) (3)
Synthesis and Biological Activity of N-(arylsulfonyl) Valine Hydrazones and Assistance of NMR Spectroscopy for Definitive 3D Structure (2019) (3)
Inhibition of antibody production in rats and mice by intravenous injection of interferon-inducing amounts of Sindbis virus or E. Coli (2005) (3)
A CYCLOBUTANE CARBONUCLEOSIDE WITH MARKED SELECTIVITY AGAINST TK+ AND TK− VARICELLA ZOSTER VIRUS (2001) (3)
Mycophenolic acid, an immunosuppressive agent, inhibits replication in cultures of primary an immortalized human hepatocytes (1997) (3)
Strategies for the treatment of dengue virus infections: a narrative account (2010) (3)
Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli. (1981) (3)
5(E)-(3-azidostyryl)-2'-deoxyuridine 5'-phosphate is a photoactivated inhibitor of thymidylate synthetase. (1980) (3)
Synthesis of Stilbene-Based Resveratrol Analogs as Cytotoxic Agents (2016) (3)
Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine). (1984) (3)
Design, Synthesis and Anti-HIV-1 Evaluation of Novel Arylazolylthioacetanilides as Potent NNRTIS (2009) (3)
Synthesis and Biological Evaluation of Some Acyclic Pyridine C-Nucleosides. Part Two (1994) (3)
One-Pot Synthesis of Novel 3-(2-Oxo-2H-chromen-3-yl)-[1,3,4] Thiadiazino [2,3-b] Quinazolin-6 (2H)-ones Under Microwave Irradiation (2007) (3)
Synthesis of Unusual Bicyclic Nucleosides Bearing an Unsaturated Side-Chain, as Potential Inhibitors of Varicella-Zoster Virus (VZV) (2003) (3)
Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles. (2006) (3)
(E)-5-(2-bromovinyl)-2'-deoxyuridine not embryotoxic compared to related nucleoside analogues in chick embryos. (1987) (3)
SVLM21, a mutant of Sindbis virus able to grow in Aedes albopictus cells in the absence of methionine, shows increased sensitivity to S-adenosylhomocysteine hydrolase inhibitors such as neplanocin A. (1988) (3)
Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features. (2022) (3)
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis. (1991) (3)
Polysulfates: chemistry and potential as antiviral drugs (1997) (3)
An intriguing and facile one-pot catalytic synthesis of N-alkylated lactams (2013) (3)
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses. (2021) (3)
Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic of 2-methylthioinosinic acid (1975) (3)
Systematic Synthesis and Biological Evaluation of α- and β-Lyxofuranosyl Nucleosides of the Five Naturally Occurring Nucleic Acid Bases. (1987) (3)
Erratum to “Are 5′-O-Carbamate-2′,3′-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?”[Bioorg. Med. Chem. Lett. 13 (2003) 2459] ☆ (2003) (3)
New trends in antiviral chemotherapy. (1979) (3)
5‐O‐ALKYLATED DERIVATIVES OF 5‐HYDROXY‐2′‐DEOXYURIDINE AS POTENTIAL ANTIVIRAL AGENTS. ANTI‐HERPES ACTIVITY OF 5‐PROPYNYLOXY‐2′‐DEOXYURIDINE (1978) (3)
New perspectives for the chemotherapy and chemoprophylaxis of AIDS (acquired immune deficiency syndrome). (1992) (3)
Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives (2011) (3)
A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate. (2009) (3)
A medicinal chemist who reshaped the antiviral drug industry: John Charles Martin (1951–2021) (2021) (3)
Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds (2013) (3)
Systematic Synthesis and Biological Evaluation of α - and β-D-Xylo- and Lyxofuranonucleosides of the Five Naturally Occurring Nucleic Acid Bases (1987) (3)
Synthesis and Biological Evaluation of some Acyclic Nucleoside Cyclic Phosphoramidate Derivatives (1987) (3)
HIV Life Cycle: Targets for Anti‐HIV Agents (2011) (3)
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds (1984) (3)
N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies (2012) (3)
Anti‐DNA Virus Agents (2010) (3)
Molecular structures and ab initio molecular orbital calculations of the optically active derivatives of 1-aminocyclopropane-1-carboxylic acid (2003) (3)
Anti-HIV combination therapy and resistance management (1998) (3)
Unusual Lability of 5′-O-tert-Butyldimethylsilyl Group On 4″-Acyl TSAO Derivatives (2003) (3)
High-performance liquid chromatographic analysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine and its metabolites in serum, urine and herpes simplex virus type-1 infected cells. (1986) (3)
Biochemical pharmacology of nucleoside and non-nucleoside analogues active against HIV reverse transcriptase (1998) (3)
Discovery of Small Molecular Inhibitors Targeting HIV-1 gp120—CD4 Interaction Drived from BMS-378806 (2014) (3)
Synthesis and Biological Activity of a Series of Methylene-Expanded Oxetanocin Nucleoside Analogues (2002) (3)
Evaluation of Antiviral and Cytotoxic Activities of Methanolic Extract of Thespesia Populnea (Malvaceae) Flowers (2011) (3)
Chemistry of Niobium Chlorides in the CsCl--NaCl Eutectic Melt. 1. Electromotive Force Measurements of NbCl3 in the CsCl--NaCl Eutectic Melt at Temperatures between 600 and 700 degrees C. (1994) (3)
Interferon induction by nucleic-acid-treated newcastle disease virus (1968) (3)
Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus: Effect of Terminal Aryl Substitution in the Side-Chain (2002) (3)
Purine Derivatives of 1,2-Disubstituted Cyclohexane Analogues of Nucleosides (2003) (3)
Synthesis and Fluorescent Properties of 6‐(4‐Biphenylyl)‐3,9‐dihydro‐9‐oxo‐5H‐imidazo[1,2‐A]purine Analogues of Acyclovir and Ganciclovir (2004) (3)
Structure-Based Discovery of Novel NH2-Biphenyl-Diarylpyrimidines as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Safety: From NH2-Naphthyl-Diarylpyrimidine to NH2-Biphenyl-Diarylpyrimidine. (2022) (3)
Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents (2000) (3)
Treatment ofHumanImmunodeficiency VirusType1 (HIV-1)-Infected Cells withCombinations ofHIV-1-Specific Inhibitors Results ina Different Resistance Pattern Than DoesTreatment withSingle-Drug Therapy (1993) (3)
Selective PCR for the detection of HIV-1 drug resistance mutations in the follow-up of HIV-1 infected patients (1998) (3)
New Analogs of Acyclovir Substituted at the Side Chain (2007) (3)
Molecular Targets for Selective Antiviral Chemotherapy (1988) (3)
Rubella virus interference and interferon production (2005) (3)
5′,5′-Di-O-nucleosyl-O′-benzylphosphotriesters as Potential Prodrugs of 3′-Azido-2′,3′-dideoxythymidine-5′-monophosphate. (1996) (3)
Antiviral effects of plasma and milk proteins: Lactoferrin shows potent antiviral activity on both HIV and HCMV replication in vitro in the same concentration range (1996) (3)
Lack of retinal toxicity of the anti-CMV drug (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) (1991) (3)
Lipophilic α‐Hydroxybenzylphosphonates as Prodrugs of 3′‐Azido‐2′ ,3′‐dideoxythymidine (AZT). (1996) (3)
Antiviral effects of milk proteins: Acylation results in polyanionic compounds with potent activity against HIV type I and II in vitro (1996) (3)
Interferon Induction by Synthetic Polynucleotides : Recent Developments (1979) (3)
Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. (2022) (3)
Synthesis of Some Novel Heterocyclic Compounds Derived from Diflunisal Hydrazide as Potential Antiinfective and Antiinflammatory Agents. (2007) (3)
Topical BVDU plus low-dosage steroids in the treatment of chronic relapsing zoster keratouveitis (1989) (3)
A Methylated Derivative of 5′-Noraristeromycin. (1997) (3)
Antitumor Activity of Silica Gel PF 254 Eluate (1973) (3)
The role of tenofovir in the prevention of HIV infections. (2006) (3)
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels. (1989) (3)
Gammaherpesviruses encode functional dihydrofolate reductase activity. (2002) (3)
The emerging role of fusion inhibitors in HIV infection. (1999) (3)
Relationship between cell-interaction and antiviral activity of polyriboinosinic acid-polyribocytidylic acid in different cell cultures. (1973) (3)
Synthesis and anti-HCMV Activity of 1-Acyl-β-lactams and 1-Acylazetidines Derived from Phenylalanine. (2004) (3)
5-(thien-2-yl)-2'-deoxyuridine - a new and potent inhibitor of herpes-simplex virus type-1 replication (1991) (2)
SYNTHESIS AND EVALUATION OF ANTIVIRAL ACTIVITY OF HIGHER HOMOLOGUES OF XYLO-CARBOCYCLIC NUCLEOSIDES (2001) (2)
Pharmacokinetics of the anti-HIV Bicyclam SID791 (JM3100) in Rabbits, as Determined by both Analytical and Bio-Assay Methods (1996) (2)
4′′-H-TSAO-T, a Novel Prototype in the HIV-1 Specific TSAO Family (2001) (2)
Synthesis and Antiviral Activity of 5-Heteroaryl-Substituted 2′- Deoxyuridines. (1991) (2)
The effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on DNA repair and mutagenesis of herpes simplex virus type 1. (1987) (2)
Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: The Effect of Branching in the p-Alkylphenyl Side Chain. (2006) (2)
Synthesis of 2'-azido-2',3'-didehydro-2',3'-dideoxythymidine (1993) (2)
Stereospecific Synthesis and Anti-HIV Activity of (Z)2′- and (E)3′-Deoxy-2′(3′)-C-(chloromethylene) Pyrimidine Nucleosides (1995) (2)
“Lock-in” modified cycloSal-D4TMP and BVDUMP triesters – extension of a pronucleotide system (2003) (2)
New Synthesis and Antitumor Activity of cycloSal‐Derivatives of 5‐ Fluoro‐2′‐deoxyuridinemonophosphate. (1997) (2)
In vitro synergy between the CD4 down-modulating compound, CADA, and multiple anti-HIV drugs (2003) (2)
Antiviral activity towards VSV and Mengo virus of a chemically stabilized 2-5A analog upon microinjection into HeLa cells. (1985) (2)
Carbocyclic Oxetanocins Lacking the C-3′ Methylene. (2010) (2)
Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. (2022) (2)
Syntheses and anti-HIV Activities of (.+-.)-Norcarbovir and (.+-.)-Norabacavir. (2007) (2)
Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene (2002) (2)
Inhibitors of reverse transcriptase and retrovirus replication. (1985) (2)
SYNTHESIS AND BIOLOGICAL EVALUATION OF N- AND O-ALKYLATED BICYCLIC FURANOPYRIMIDINES AS NON-NUCLEOSIDIC INHIBITORS OF HUMAN CYTOMEGALOVIRUS (2005) (2)
Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety (1997) (2)
Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6‐(Aminomethyl)purines and Purine‐6‐carboxamidines. (1997) (2)
Practical and Efficient Synthesis of Pyrano[3,2‐c]pyridone, Pyrano[4,3‐b]pyran and Their Hybrids with Nucleoside as Potential Antiviral and Antileishmanial Agents. (2010) (2)
A Mercapto Analogue of 5′‐Noraristeromycin. (2002) (2)
IMPROVED SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITIES OF 5-CYANOURIDINE AND 5-CYANO-2′-DEOXYURIDINE (1977) (2)
Design, synthesis, and biological evaluation of novel 5‐Alkyl‐6‐Adamantylmethylpyrimidin‐4(3H)‐ones as HIV‐1 non‐nucleoside reverse‐transcriptase inhibitors (2016) (2)
Efficacy of PMEG [9-(2-phosphonylmethoxyethyl)-guanine] and its prodrug cPr-PMEDAP [9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine in organotypic cultures of normal and papillomavirus ((HPV)-positive keratinocytes (2004) (2)
Erratum: Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetraacetyl esters (Molecular Pharmacology (2000) 58 (641-648)) (2001) (2)
Effects of Ionenes on Interferon Induction by Poly(Inosinic Acid)·Poly(Cytidylic Acid) (1977) (2)
1984—Discovery of the First Anti-HIV Drug, Suramin (2021) (2)
Virus resistance to the CXCR4 inhibitor AMD070 develops slowly and does not induce a co-receptor switch (2004) (2)
Non-Nucleoside Structures Retain Full Anti-HCMV Potency of the Dideoxy Furanopyrimidine Family (2004) (2)
Synthesis, conformation analysis and biological evaluation of 2-(2,3-dideoxy-beta-D-ribofuranosyl)pyridine-4-carboxamide. (1996) (2)
A Comparative Study of 5-ethyl-2′-Deoxyuridine and Selected Lipophilic 5,6-Dihydro Double/Triple Prodrugs (1995) (2)
Efficacy of HPMPC in the treatment of CMV infections in various animal models (1993) (2)
Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues (2012) (2)
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue. (1991) (2)
Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity. (2021) (2)
Synthesis of 1‐(2‐deoxy‐β‐D‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents (2001) (2)
Neutralization of Interferon Activity in Homologous and Heterologous Cells with Homologous and Heterologous Antibody (1980) (2)
Cellular receptors as targets for anti-human immunodeficiency virus agents (2001) (2)
Polyanion inhibitors of human immunodeficiency virus. Part IV. - polymerized anionic surfactants: Influence of the density and distribution of anionic groups on the antiviral activity (1996) (2)
Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates. (1989) (2)
cyclo‐Saligenyl‐2′,3′‐dideoxy‐2′,3′‐didehydrothymidinemonophosphate (cycloSal‐d4TMP) — A New Pronucleotide Approach. (1998) (2)
Synthesis and Cytostatic Activities of New 6‐Substituted Purinylcarbonucleosides Derived from Indan. (2002) (2)
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents. (1995) (2)
Perspectives for the chemotherapy of HIV infection : an introduction (1990) (2)
SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY EVALUATION OF 9-(2-AZIDO-2,3-DIDEOXY-β-D-THREO-PENTOFURANOSYL)ADENINE DERIVATIVES (2001) (2)
Synthesis, Cytostatic and Antiviral Activity of Some Ruthenium (II) Complexes (2014) (2)
92 Ara-A-5′-phenyl methoxy alaninyl phosphate as a prodrug of the adenine arabinoside -monophosphate: synthesis and anti viral evaluation (2000) (2)
Methods in Anti-HCMV Research. (2000) (2)
Anthracyclinones. Part 5. Synthesis of some anthracyclinones and 4-hydroxyanthracyclinones containing a tertiary methyl carbinol function in ring A from D-glucose precursors (1990) (2)
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection. (1984) (2)
1,2,4‐Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV‐1) in vitro. (2002) (2)
SYNTHESIS OF IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS POSSIBLE BIOLOGICALLY ACTIVE AGENTS. (2016) (2)
Inhibitory effects of various derivatives of azidothymidine triphosphate on reverse transcriptase and DNA polymerases (1988) (2)
Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives. (2011) (2)
Specific Hiv-1 Inhibitors Targeted At The Hiv-1 Rt (1993) (2)
Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides. (1999) (2)
Synthesis and Biophysical and Biological Properties of Oligonucleotides Containing 2-Aza-2′-Deoxyinosine. (1996) (2)
Failure of Athymic-Nude Mice Sensitized with Bacillus Calmette-Guérin to Produce Interferon in Response to Purified Protein Derivative (1983) (2)
Thiosugars. X. Novel Nucleoside Analogues Derived from 4-Thio-L-lyxofuranose (2003) (2)
Sulfated polymers as inhibitors of HIV replication (1990) (2)
Cytotoxic and anticancer properties of some 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinols and related compounds. (2001) (2)
From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface (2022) (2)
Outlook of the Antiviral Drug Era, Now More Than 50 Years After Description of the First Antiviral Drug (2011) (2)
Low dose intravitreal HPMPC (CIDOFOVIR) therapy for CMV retinitis in patients with aids (1996) (2)
5‐Alkyl‐2‐[(aryl and alkyloxycarbonylmethyl)thio]‐6‐(1‐naphthylmethyl) Pyrimidin‐4(3H)‐ones as an Unique HIV Reverse Transcriptase Inhibitors of S‐DABO Series. (2004) (2)
Optimal Treatment Regimens for 5′‐Deoxy‐5‐fluorouridine, with or without (E)‐5‐(2‐Bromovinyl)‐2′‐deoxyuridine, against Various Tumors in Mice (1990) (2)
Expression of HIV‐1 integrase in CEM cells inhibits HIV‐1 replication (2004) (2)
Interferon inducing activity of (A)n.(U)n complexes of varying chain length. (1978) (2)
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3 TC and non-nucleoside reverse transcriptase inhibitors ( lamivudine y HIV-1 y resistance y combination therapy ) (1996) (2)
Potential drugs for the treatment of AIDS. (1989) (2)
SYNTHETIC INTERFERON INDUCERS (1975) (2)
Studies on the mechanism of antiviral action of 5-(2-chloroethyl)-2'-deoxyuridine against herpes-simplex virus (1988) (2)
Novel 6-Azapyrimidine-2′-Deoxy-4′-Thionucleosides: Synthesis, Biological Evaluation and Conformational Analysis (1999) (2)
Current leads in antiviral chemotherapy. (1986) (2)
Synthesis and Anti‐HIV‐1 Activity of 4,5,6,7‐Tetrahydro‐5‐methylimidazo(4,5,1‐jk)(1,4)benzodiazepin‐2 (1H)‐one (TIBO) Derivatives. Part 2. (2010) (2)
Inhibition of the replication of DNA viruses by phosphonylmethoxyalkyl-purines and -pyrimidines. (1989) (2)
Selective Inhibition of Myxovirus Replication by a Novel Series of Cholesterol-Naphthalenesulfonic Acid Hybrid Molecules (1994) (2)
Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs. (2021) (2)
Non‐nucleoside HIV Reverse Transcriptase Inhibitors. Part 6. Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues. (2006) (2)
Experimental herpetic keratitis in rabbit corneal organ cultures. (1984) (2)
Design , Synthesis , Anti-HIV Activity and Cytotoxicity of Novel Schiff ’ s base of Indeno [ 1 , 2-b ] quinoxalin-11-one Derivatives (2013) (2)
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. (2022) (2)
Synthesis and cytotoxic activity of some mononuclear Ru(II) Complexes (2010) (2)
Synthesis and Antiviral Evaluation of N‐β‐D‐Ribosides of Ergot Alkaloids. (1997) (2)
Effect of polyanionic compounds on intracutaneous and intravaginal herpes virus infection in mice: Impact on the search for vaginal microbicides (1995) (2)
Discovery of a new family of bicyclic dideoxy nucleosides which inhibit HCMV by a non-nucleoside mechanism (2003) (2)
Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs. (2022) (2)
Eco‐Friendly Synthesis and Biological Evaluation of New Quinoline‐Based Dialkyl α‐Aminophosphonates. (2008) (2)
Synthesis and Biological Evaluation of Phosphonate Derivatives of Some Acyclic Pyridine-C-Nucleosides (1998) (2)
Handbook of viral bioterrorism and biodefense (2003) (2)
Editorial overview: Antiviral strategies. (2016) (2)
Antiviral Research, at its 30th anniversary, remembrances from its Editor-in-Chief. (2011) (2)
Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture. (2001) (2)
Identification of the real molecular target for HIV inhibitors. (2000) (2)
Current leads in antiviral chemotherapy (1986) (2)
Synthesis and Antiretrovirus Properties of 5′-Isocyano-5′- deoxythymidine, 5′-Isocyano-2′,5′-dideoxyuridine, 3′-Azido-5′-isocyano- 3′,5′-dideoxythymidine, and 3′-Azido-5′-isocyano-2′,3′,5′- trideoxyuridine. (1991) (2)
Synthesis, determination of sequence selective DNA minor groove binding and biological evaluation of hybrid bithiazole-linked netropsin derivatives (1992) (2)
Therapeutic strategies for human poxvirus infections: Monkeypox (mpox), smallpox, molluscipox, and orf (2022) (2)
New antiviral target on HIV-1 reverse transcriptase revealed by TIBO derivatives (1991) (2)
Antiviral Activity of Bicyclic Pyrimidine Nucleosides (1995) (2)
SYNTHESIS AND IN VITRO CYTOTOXIC AND ANTIVIRAL ACTIVITIES OF 1-(2,5,6-TRIDEOXY-6-HALOGENOHEPT-5-ENOFURANURONONITRILE)THYMINE AND DERIVATIVES (2002) (2)
Synthetic interferon inducers. (1974) (2)
2′‐Fluorinated Arabinonucleosides of 5‐(2‐Haloalkyl)uracil: Synthesis and Antiviral Activity. (1987) (2)
Mechanism of Antiviral Action of 5-Substituted 2′-Deoxyuridines: ( E )-5-(2-Iodovinyl)-2′-Deoxyuridine (IVDU) as Compared to its Carbocyclic Analogue (C-IVDU) (1987) (2)
Vesicular stomatitis virus (VSV) as a paradigm for predicting antiviral activity against Ebola virus (EBOV) (2015) (2)
Synthesis of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents. (2002) (2)
Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity. (1999) (2)
Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End (1987) (2)
1H)-One and-Thione Derivatives ArePotent Inhibitors ofHuman Immunodeficiency Virus Type1Replication andAre Synergistic with2',3'-Dideoxynucleoside Analogs (1994) (2)
Acyclic Nucleotide Analogues Derived from 8-Azapurines: Synthesis and Antiviral Activity. (2010) (2)
Effect of chlorite-oxidized oxyamylose on Moloney sarcoma virus-induced tumor formation in mice. (1972) (2)
Antiviral drug susceptibility of herpes simplex type 1 (HSV-1) strains emerging under the selective pressure of (S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl)cytosine (HPMPC) in vitro (1995) (2)
Susceptibilities of several drug-resistant varicella-zoster virus (VZV) strains to bicyclic pyrimidine nucleoside analogues (BCNAs) (2002) (2)
Trends in the development of new antiviral agents for the chemotherapy of infections caused by herpesviruses and retroviruses (1995) (2)
Characterization of the Catalytic Subunit of the Human Herpesvirus 6 (HHV-6) DNA Polymerase Expressed in an In Vitro Transcription/Translation Assay (2003) (2)
ANTIVIRAL ACTIVITY OF C-5 SUBSTITUTED TUBERCIDIN ANALOGS (1984) (2)
Procedures for the measurement of interferon mRNA distribution in induced mouse cells. (1981) (2)
N‐Deoxyribosides of Ergot Alkaloids: Synthesis and Biological Activity. (1997) (2)
Strategies for the treatment and prevention of cytomegalovirus infections. (1993) (2)
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity. (1994) (2)
Chimeric virus technology (CVT) for HIV env-genes to evaluate the resistance/susceptibility profile towards HIV entry inhibitors (2002) (2)
Retrospective analysis of therapy response to the initial therapy in 91 treatment-naive HIV-1 patients with and without baseline resistance mutations as measured by LiPA (2001) (2)
Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives (2001) (2)
Synthesis and Biological Evaluation of New 5,6-dichlorobenzimidazole Nucleoside Derivatives (1994) (2)
BIOLOGICAL ACTIVITY AND A MODIFIED SYNTHESIS OF 8-AMINO-3-β-D-RIBOFURANOSYL-1,2,4-TRIAZOLO(4,3-α)PYRAZINE, AN ISOMER OF FORMYCIN (1984) (2)
Synthesis and Antiviral/Antiproliferative Activity of Some N-Sulfonylbenzimidazoles. (2003) (2)
Differential affinities of pyrimidine nucleoside analogues for deoxythymidine and deoxycytidine kinase determine their incorporation into murine leukemia L1210 cells. (1987) (2)
Efficacy of antiherpetic drugs in combined gene/chemotherapy of cancer is not affected by a specific nuclear or cytoplasmic compartmentation of herpes thymidine kinases (1999) (2)
New anti-HIV Agents and Targets (2003) (2)
Guanosine Analogues as anti‐Herpesvirus Agents (2002) (2)
Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir (2001) (2)
Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues. (2011) (2)
6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins. (2017) (2)
Preliminary results on the activity of cidofovir for the treatment of cervical intraepithelial neoplasia (CIN) grade III (1997) (1)
Synthesis and biological evaluation of 2',3'-dideoxy-3'-fluororibofuranosyl purine nucleosides (1997) (1)
2',3'-O-Cyclic derivatives of ribonucleosides and their 5'-phosphonates: synthesis and anti-HIV activity (1991) (1)
New treatment strategies for dengue and other flaviviral diseases (2006) (1)
Bicyclic anti-VZV nucleosides: Thieno analogues bearing alkylphenyl side chain result in a reduction in antiviral activity (2004) (1)
Antiviral drugs: triphosphates of nucleoside analogues active as antiviral drugs (2005) (1)
Specific phosphorylation of 2-amino-7-[(1,3-dihydroxy-2-propoxymethyl)purine (S2242) in human cytomegalovirus-infected human embryonic lung fibroblasts (1995) (1)
Protection of Rabbits Against Local Vaccinia Virus Infection by Brucella abortus and Polyacrylic Acid in the Absence of Systemic Interferon Production (1973) (1)
Characterization of cowpox virus (CPV) mutants arising under pressure with different acyclic nucleoside phosphonates (2009) (1)
Real-time characterization of the interaction of HIV-1-specific inhibitors with their binding site at the HIV-1 reverse transcriptase (RT) using surface plasmon resonance and biosensor technology (1993) (1)
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues. (1991) (1)
Synthesis and in vitro Antiviral Activity Evaluation of 9‐(2‐Azido‐2,3‐dideoxy‐β‐D‐threo‐pentofuranosyl)adenine Derivatives (2001) (1)
Synthesis and Antitumor Activities of Novel Pyrimidine Derivatives of 2,3-O,O-Dibenzyl-6-deoxy-L-ascorbic Acid and 4,5-Didehydro-5,6-dideoxy-L-ascorbic Acid. (2001) (1)
CADA compounds: inhibitors of HIV and HHV-7 replication via down-modulation of CD4 receptor expression (2001) (1)
Synthesis of 5′‐N‐(α‐Amino‐β‐mercaptoacyl)amino‐5′‐deoxynucleosides as potential antiviral compounds (1991) (1)
Antimalarial chloroquine metamorphosed into antiviral agent against HIV with four modes of actions (2012) (1)
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes. (1991) (1)
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 7. Synthesis, Antiviral Activity, and 3D-QSAR Investigations of Novel 6-(1-Naphthoyl) HEPT Analogues. (2007) (1)
Stereoselective Synthesis ofNovel Aristeromycin Analogues as Potential Antiviral Agents (2008) (1)
170 Long acting therapy of viral retinitis with HPMPC (1993) (1)
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the phase I/II clinical trial drug S-1360 (2004) (1)
Anti-HIV drugs. (2007) (1)
Inhibition of terminal deoxynucleotidyltransferase by (E)-5-(2-bromovinyl)-2'-deoxyuridine 5'-triphosphate. (1983) (1)
Synthesis and Biological Evaluation of Some 4-Substituted 1-[1-(4-Hydroxybutyl)-1,2,3-triazol-(4 and 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines. (2002) (1)
Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 1. Synthesis and Structure—Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues. (2003) (1)
Ribavirin therapy for SSPE virus infection in hamster (1991) (1)
Dinucleoside Monophosphates Containing AZT and 1-Methyladenosine or 7-Methylguanosine (2003) (1)
Structure-Activity Relationship Studies on a Novel Family of Specific HIV-1 Reverse Transcriptase Inhibitors (2003) (1)
Stereospecificity of 6'-C-neplanocin A analogues as inhibitors of S-adenosylhomocysteine hydrolase activity and human immunodeficiency virus replication. (1998) (1)
Phosphoramidate Derivatives of d4T with Improved anti-HIV Efficacy Retain Full Activity in Thymidine Kinase-Deficient Cells. (1996) (1)
Stereospecific Synthesis and Antiviral Activities of β‐L‐2′,3′‐Dideoxy‐5‐chloropyrimidine Nucleoside Derivatives (1999) (1)
Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides (2003) (1)
Recent developments in the chemotherapy of HIV infections (1998) (1)
Synthesis and Antiviral Activity of the α-Analogues of 1,5- Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides). (1997) (1)
Synthesis and antiviral activity of various N4-acyl derivatives of cidofovir and its 5-azacytosine counterpart, 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine (2008) (1)
Synthesis and Anti-HIV Activity of Various 2′- and 3′-Substituted 2′,3′-Dideoxyadenosines: A Structure-Activity Analysis. (1988) (1)
Identification of the real molecular target for HIV inhibitors. (2000) (1)
Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: Synthesis and Biological Evaluation of 2′,3′‐Dideoxy‐3′‐fluoro and 2′‐Deoxy‐xylo Derivatives (2004) (1)
Metabolic and Pharmacological Characteristics of the Bicyclic Nucleoside Analogues (BCNAs) as Highly Selective Inhibitors of Varicella—Zoster Virus (VZV) (2004) (1)
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues. (1999) (1)
Synthesis and Evaluation of Antiviral Activity of 3′-C-Cyano-3′-Deoxynucleosides (1989) (1)
Potent and highly selective HIV-1 specific inhibition by a new series of alfa- anilino-phenylacetamide (alfa-APA) derivatives targeted at HIV-1 RT (1992) (1)
Retinoids as potential chemotherapeutic agents. Synthesis, cytostatic and differentiating activities of new heterocyclic analogs of retinoic acid (1998) (1)
Potent and selective inhibition of HIV-1 and HIV-2 replication by a novel class of bicyclams targeted at viral uncoating (1992) (1)
Antitumor cell and antimetabolic effects of 5-ethyl-2′-deoxyuridine and 5′-substituted 5-ethyl-2′-deoxyuridine derivatives (2004) (1)
Difluorinated carbaacyclonucleosides: Synthesis and evaluation of antiviral activity (2001) (1)
New bicyclic nucleoside analogues (BCNAs) show selective and specific activity against human cytomegalovirus (HCMV) (2003) (1)
Allosteric properties of heterodimeric HIV-1 reverse transcriptase (1991) (1)
Recent trends and development in antiviral chemotherapy. (1985) (1)
Chemotherapy of human immunodeficiency virus (HIV) infection based on chemotherapeutic intervention with early steps of the virus replicative cycle. (1995) (1)
New analogues on anthracycline antibiotics containing 2,3,6-trideoxy-3-amino-3-C-methyl-L-arabino-hexose (L-eremosamine) (1991) (1)
SYNTHESIS AND FLUORESCENT PROPERTIES OF THE TRICYCLIC ANALOGUES OF ACYCLOVIR LINKED WITH NITROGEN HETBROCYCLIC UNITS (2005) (1)
HIV Reverse Transcriptase Inhibitors (2010) (1)
Palladium‐Catalyzed Aryl Amination Reactions of 6‐Bromo‐ and 6‐Chloropurine Nucleosides. (2010) (1)
Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein (2022) (1)
Bicyclic anti‐VZV Nucleosides: Thieno Analogues Bearing an Alkylphenyl Side Chain Have Reduced Antiviral Activity. (2004) (1)
Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1. (2004) (1)
Anti-HIV Derivatives of 1-(2,3-Dideoxy-3-N-hydroxyamino-β-D-threo- pentofuranosyl)thymine. (1995) (1)
Synthesis of 4‐Substituted‐1,2,3‐triazole Carbanucleoside Analogues of Ribavirin via Click Chemistry. (2008) (1)
Squamous papilloma of the oesophagus and human papilloma virus (1994) (1)
Chemotherapy of the acquired immune deficiency syndrome (AIDS): non-nucleoside inhibitors of the human immunodeficiency virus type 1 reverse transcriptase. (1991) (1)
Synthesis, Anti-HIV and Cytotoxic Activity of Some Novel Isatine-Sulfisomidine Derivatives (2011) (1)
Synthesis and Cytotoxic Activity of Nind-Alkoxy Derivatives of Antibiotic Arcyriarubin and Dechloro-rebeccamycin Aglycon. (2003) (1)
Stereoselective synthesis of sugar-modified enyne analogues of adenosine and uridine. Interaction with S-adenosyl-L-homocysteine hydrolase and antiviral and cytotoxic effects. (2004) (1)
Synthesis of Novel Aza‐Analogues of Tiazofurin with 2‐[5,5‐Bis(hydroxymethyl)pyrrolidin‐2‐yl] Framework as Sugar Mimic. (2012) (1)
Synthesis of 5-(4-hydroxy-3-methylphenyl) -5- (substituted phenyl)-4, 5-dihydro-1H-1-pyrazolyl-4-pyridylmethanone derivatives with anti-viral activity. (2007) (1)
Geiparvarin Analogues. Part 4. Synthesis and Cytostatic Activity of Geiparvarin Analogues Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain. (1994) (1)
Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents. (2013) (1)
Activity of novel acyclic pyrimidine nucleoside phosphonates against poxviruses (2004) (1)
Influence of initial conditions on the development of resistance to TIBO derivatives in cell culture (1992) (1)
An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs. (1999) (1)
Design and synthesis of phosphonoacetic acid ( PPA ) ester and amide bioisosters of ribofuranosylnucleo-side diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory , cytostatic and antiviral activity (2003) (1)
Synthesis of 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine and Its Interaction with the HSV‐1 Thymidine Kinase. (1996) (1)
3′-(N-Hydroxyimino)-2′,3-dideoxynucleosides and Their Derivatives: Synthesis, Broad Spectrum Antiviral Properties and Synthetical Application for the Preparation of Other Nucleoside Analogues (1999) (1)
Synthesis and Biological Evaluation of Some Acyclic α‐(1H‐Pyrazolo[3,4‐d]pyrimidin‐4‐yl)thioalkylamide Nucleosides. (2002) (1)
N‐3 Substituted TSAO Derivatives as a Probe to Explore the Dimeric Interface of HIV‐1 Reverse Transcriptase (2004) (1)
Modes of action of interferon and analogues of 2-5A, a mediator of interferon action (1984) (1)
Influence of the 2-Substituent on the Activity of Imidazo[1,2-a]pyridine Derivatives Against Human Cytomegalovirus. (2002) (1)
Nucleoside/Nucleotide Inhibitors of HIV Reverse Transcriptase (2003) (1)
Comparative effect of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine treatment on cytomegalovirus-induced interstitial pneumonitis in allogeneic bone marrow transplant recipient rats. (1993) (1)
SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME 2-{4-[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL] PHENOXY}-N-PHENYLACETAMIDE. (2017) (1)
HEPT Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442). (1995) (1)
Influenza virus inhibitors available for the chemotherapy and/or chemoprophylaxis of influenza virus infections. (2006) (1)
Nucleotides. Part 32. Synthesis of 2′-5′ Connected Oligonucleotides. Prodrugs for Antiviral and Antitumoral Nucleosides. (1990) (1)
Differential metabolism of (E)-5-(2-bromovinyl)-2'-deoxyuridine in wild-type and drug-resistant herpes simplex virus-infected cells. (1985) (1)
Chemotherapeutic approach of AIDS. (1988) (1)
Status Presens of Antiviral Drugs And Strategies: Part I: DNA Viruses and Retroviruses (2007) (1)
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES. (2016) (1)
CorrigendumCorrigendum to “Enantioselective synthesis of homocarbocyclic-2′-oxa-3′-azanucleosides”: [Tetrahedron 62 (2006) 1171–1181] (2007) (1)
Antiviral Activity of 3‐(3,5‐Dimethylbenzyl)uracil Derivatives Against HIV‐1 and HCMV (2008) (1)
In vitro and in vivo inhibition of virus multiplicaton by microwave hyperthemia. (1977) (1)
Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin (1991) (1)
2',3'-Dideoxynucleoside analogues as inhibitors of human immunodeficiency virus (1989) (1)
Inhibiting effects of PMEG [9-(2-phosphonylmethoxyethyl)guanine] on the growth of human cervical carcinoma xenografts in athymic nude mice (2005) (1)
NH2-terminal processing of chemokines (RANTES, SDF1-alpha) by CD26/dipeptidylpeptidase IV generates inhibitors of chemotaxis and HIV-1 infection (1998) (1)
New acquisitions in the chemotherapy of viral infections. (1990) (1)
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC): successful treatment of a patient with disseminated esophageal and hypopharyngeal papillomatosis (1994) (1)
Synthesis and Anti-HIV Activity Evaluation of 2-(5-(Naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides Derivatives (2012) (1)
Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety (2003) (1)
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [HPMPC] against intraperitoneal and intracerebral murine cytomegalovirus infections (1991) (1)
Antiviral chemotherapy today and tomorrow. (1988) (1)
Antiviral drug discovery: Ten more compounds, and ten more stories (part B) (2009) (1)
3′-Fluoro-2′,3′-dideoxy-5-chlorouridine (I): Most Selective Anti-HIV-1 Agent Among a Series of New 2′- and 3′-Fluorinated 2′,3′-Dideoxynucleoside Analogues. (1990) (1)
4‐(β‐Arylvinyl)‐3‐(β‐arylvinylketo)‐1‐ethyl‐4‐piperidinols and Related Compounds: A Novel Class of Cytotoxic and Anticancer Agents. (1999) (1)
Construction of a synthetic gene for high level expression of active HIV-1 integrase in human cells (2000) (1)
4 Viral entry as the primary target of anti-HIV activity of chicoric acid and its tetra-acetyl esters (2000) (1)
The Twenty-Second International Conference on Antiviral Research (2009) (1)
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines. (2009) (1)
Antiviral drug development--success and failure: a personal perspective with a Japanese connection. (2013) (1)
Intracellular Metabolism of Cyclo Saligenyl 3 9-Azido-2 9 , 3 9-dideoxythymidine Monophosphate , a Prodrug of 3 9-Azido-2 9 , 3 9-dideoxythymidine ( Zidovudine ) (1999) (1)
Sugar and Base-Modified 2′,3′-Dideoxynucleosides as Potential Anti-Aids Drugs (1989) (1)
Reduced pathogenicity of phenotypically and genotypically characterized cidofovir (CDV)-resistant vaccinia virus (VV) (2005) (1)
Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: from S=O to CHOR (2022) (1)
Spiro[pyrrolidine‐2,2′‐adamantanes]: Synthesis, Antiinfluenza Virus Activity and Conformational Properties. (2003) (1)
MODIFIED CYCLOBUTANE CARBONUCLEOSIDES: SYNTHESIS AND EVALUATION OF THEIR ANTIVIRAL ACTIVITY (2001) (1)
Initiation of HAART in drug naive HIV-1 patients prevents viral breakthrough for up to 43 months in 60% of the patients (2000) (1)
Perspectives for antivirals to limit SARS-CoV-2 infection (COVID-19) (2021) (1)
SYNTHESIS AND ANTIVIRAL ACTIVITIES OF ARABINOFURANOSYL-5-ETHYLPYRIMIDINE NUCLEOSIDES. SELECTIVE ANTIHERPES ACTIVITY OF 1-(β-D-ARABINOFURANOSYL)-5-ETHYLURACIL (1979) (1)
Synthesis and Antiviral Evaluation of Some 3′-Fluoro Bicyclic Nucleoside Analogues. (2004) (1)
Inhibition of Oncornavirus Activities by Polynucleotide Analogues (1979) (1)
Antiinfluenza Virus Agents: Synthesis and Mode of Action (2008) (1)
Identification of the type of cells responsible for transfer of herpes simplex virus (HSV) and vaccinia virus (VACV) infection to epithelial cells grown in 3D (2009) (1)
Concentration of interferon by nucleic acid precipitation. (1969) (1)
Synthesis and Antiviral Evaluation of 2′‐C‐Methyl Analogues of 5‐Alkynyl‐ and 6‐Alkylfurano‐ and Pyrrolo[2,3‐d]pyrimidine Ribonucleosides. (2010) (1)
Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-O-(N-acyl) Phosphoramidates (2011) (1)
Mannose-specific plant lectins as potential HIV microbicides (2004) (1)
Bicyclic Furo Pyrimidine Nucleosides with Aryloxyphenyl and Halophenyl Substituted Side Chains as Potent and Selective Varicella—Zoster Virus Inhibitors (2001) (1)
The potent anti-human immunodeficiency virus (HIV) compounds 3'-azido-2',3'-dideoxythymidine (AzddThd), 3'-fluoro-2',3'-dideoxy-thymidine (FddThd) and 2',3'-didehydro-2',3'-dideoxythymidine (D4T) show marked differences in their intracellular phosphorylation pattern (1989) (1)
HIV-1 transcription in vivo-1-1 2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5 6 7 (2007) (1)
Comparison of RT gene sequences from HIV-1 strains with different sensitivity to TIBO derivatives (1992) (1)
Novel 3‐(2‐Adamantyl)pyrrolidines with Potent Activity Against Influenza A Virus — Identification of Aminoadamantane Derivatives Bearing Two Pharmacophoric Amine Groups. (2001) (1)
Synthesis, Antiviral, and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 1. Guanosine Analogues. (1997) (1)
Discovery of Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors from Arylthioacetanilide Structural Motif (2015) (1)
Antiviral chemotherapy in 2009: quo vadis? (2009) (1)
Bicyclic Nucleoside Inhibitors of Varicella—Zoster Virus: 5′-Chloro and 3′-Chloro Derivatives (2004) (1)
Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T and DDC + (1996) (1)
Antiherpes drugs: promises and pitfalls. (1984) (1)
Another Ten Stories in Antiviral Drug Discovery. Part C. “Old” and “New” Antivirals, Strategies, and Perspectives (2009) (1)
Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity. (2022) (1)
Classical Antiviral Agents and Design of New Antiviral Agents (1996) (1)
Synthesis and Antiviral Evaluation of 3-(2,3-Dihydroxypropyl)furo[2,3-d]pyrimidin-2(3H)-ones (2010) (1)
Differential antiviral activity of several IMP dehydrogenase inhibitors (1997) (1)
Establishment of a human cell line that constitutively expresses high levels of HIV-1 integrase (1999) (1)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile 2006 (1st Edition) the DNA Viruses (2006) (1)
New antiviral agent, 1-( S )-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: esters and base-modified derivatives (2008) (1)
Structure-activity relationships for interferon induction and inhibition of protein synthesis by polynucleotides. (1981) (1)
Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives. (1999) (1)
18 Synthesis and metabolic study of 1H,3H-oxazolo[3,4-a]benzimidazoles, a new class of non-nucleoside HIV-1 RT inhibitors (2000) (1)
5‐(5‐Bromothien‐2‐yl)‐2′‐deoxyuridine and 5‐(5‐Chlorothien‐2‐yl)‐2′‐ deoxyuridine are Equipotent to E‐5‐(2‐Bromovinyl)‐2′‐deoxyuridine in the Inhibition of Herpes Simplex Virus Type I Replication. (1991) (1)
Flaviviridae with Perspectives for the Treatment of Infections (1999) (1)
NUCLEIC ACID RELATED COMPOUNDS. 47. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PYRIMIDINE AND PURINE “ACYCLIC” NUCLEOSIDE ANALOGS (1985) (1)
env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors (2003) (1)
New developments in anti-HIV chemotherapy. (2002) (1)
In Search of Antiviral Compounds Against the AIDS Virus (1987) (1)
SYNTHESIS, ANTI-HIV ACTIVITY AND CYTOTOXICITY OF 2-PHENYL, 3-SULPHONAMIDO QUINAZOLIN-4 (3H) -ONES (2012) (1)
N-[2-Hydroxyethoxy)methyl] derivatives of bicyclic furano and pyrrolo pyrimidines and their antiviral evaluation (2004) (1)
Synthesis and biological activities of (Z) and (E) alpha-ethenyl acyclonucleosides. (2001) (1)
Pre-clinical development of the BCNAs: The most potent anti-VZV agents reported to date (2006) (1)
Strategies in the Development of Antiviral Agents (1988) (1)
Adducts of Mannose 6-Phosphate with 5-Iodo-2′-Deoxyuridine and 2-5A as Potential Antiviral Agents (1989) (1)
SYNTHESIS AND ANTIVIRAL PROPERTIES OF (Z)-5-(2-BROMOVINYL)-2′-DEOXYURIDINE (1981) (1)
Adefovir dipivoxil (2012) (1)
5′-O-Phosphonomethyl-2′,3′-dideoxynucleosides: Synthesis and Anti-HIV Activity. (1991) (1)
The Imidazopyrrolopyridine Analogue AG110 is a Novel, Highly Selective Inhibitor of Pestivirus Replication and Targets the viral RNA-dependent RNA Polymerase (2007) (1)
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SUBSTITUTED N1-[1-BENZYL-3-(3-TERT-BUTYLCARBAMOYL-OCTAHYDROISOQUINOLIN-2YL)-2-HYDROXY- PROPYL]-2-[(2-OXO-2H-CHROMENE-3-CARBONYL) AMINO] SUCCINAMIDE ANALOGS AS ΑΝΤΙ-VIRAL AND ΑΝΤΙ-HIV AGENTS (2008) (1)
Synthesis and anti‐HIV Activity of Novel Cyclopentenyl Nucleoside Analogues of 8‐Azapurine. (2007) (1)
Treatment of severe laryngeal papillomatosis with intralesional injections of Cidofovir R [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC, Vistide R], (1997) (1)
Phosphoramidate prodrugs of the most potent and selective anti-VZV bicyclic pyrimidine nucleosides (2005) (1)
Original article SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF SOME Ru(II) COMPLEXES (2011) (1)
Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2′ ‐Deoxy‐2′‐fluoropuromycin. (1995) (1)
Antiviral drug development--success and failure: a personal perspective with a Japanese connection. (2012) (1)
Application of self-compacting concrete in combination with high strength prestressing strands for precast, prestressed beams (2005) (1)
SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF SOME Ru(II) COMPLEXES (2011) (1)
Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases (2009) (1)
Phenotypic multi-nucleoside resistance linked to the Q151M mutation is enhanced under the selective pressure of acyclic nucleotide analogs but reduced by foscarnet (2000) (1)
Interferon production in rabbit kidney cell cultures exposed to poly (I). poly (C) adsorbed to rabbit red blood cells. (1974) (1)
Synthesis and Biological Activity of 5-(2,2-Difluorovinyl)-2′-deoxyuridine. (1988) (1)
2,3′-Anhydro-[l- (6′- O-benzoyl-2′,5′- dideoxy-β-D-glucofuranosyl)thymine], a Versatile Starting Material for Homo - Nucleosides (1991) (1)
Cyclopentene Carbocyclic Nucleosides Related to the Antitumor Nucleoside Clitocine and Their Conversion to 8-Aza-neplanocin Analogues. Synthesis and Antiviral Activity. (1994) (1)
Synthesis and Antiviral Activities of Novel Purinyl-and Pyrimidinyl-carbanucleosides Derived from Indan (2008) (1)
Synthesis and biological properties of 2'-substituted 2',3'-dideoxy-3'-fluoro-D-ribonucleosides (1990) (1)
Anti-HIV activity profile of a novel CCR5 inhibitor, AMD887, in combination with the CXCR4 inhibitor AMD070 (2004) (1)
Synthesis and Antiviral and Cytostatic Properties of 3′‐Deoxy‐3′‐ fluoro‐ and 2′‐Azido‐3′‐fluoro‐2′,3′‐dideoxy‐D‐ribofuranosides of Natural Heterocyclic Bases. (1991) (1)
The Twenty-Second International Conference on Antiviral Research (2009) (1)
Treatment (Bromovinyldeoxyuridine) of Varicella-Zoster Virus Infections (1988) (1)
The human fibroblast interferon gene(s) and their expression in heterologous cells. (1982) (1)
A derivate of the antibiotic doxorubicin inhibits dengue and yellow fever virus replication in vitro (2008) (1)
Synthesis and Antiviral Properties of 8-Amino-3-[(2-hydroxyethoxy)methyl]-1,2,4-triazolo[4,3-a]pyrazine. (1986) (1)
Selective Inhibitory Effects of (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine and 2′-Nor-cGMP on the Replication of Adenovirus In Vitro (1987) (1)
Antiviral activity of 5-substituted pyrimidine nucleoside analogues (1983) (1)
Synthesis of 2′,3′-Dideoxy-3-isoadenosine: A New Structural Analogue of the Anti-HIV Active Compound, 2′,3′-Dideoxyadenosine. (1992) (1)
Activity of different classes of nucleoside and nucleotide analogues against adenovirus in cell culture (2004) (1)
Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (2022) (1)
Synthesis and Antiviral Activity of Modified 1,2,6‐Thiadiazine Dioxide Acyclonucleosides. (1997) (1)
Mannose-specific plant lectins may qualify as efficient microbicides against human immunodeficiency virus transmission (2002) (1)
CADA inhibits HIV and HHV-7 replication by down-modulation of the cellular CD4 receptor (2001) (1)
Therapeutic potential of HPMPC as an antiviral drug (1993) (1)
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. (2001) (1)
M1009 Eradication of Intra-Anal Condylomata Acuminata and Histologically Dysplasia with Combined Intralaesional Cidofovir and Coagulations (2008) (1)
Antibiotics and antiviral agents (1991) (1)
Alopecia in laboratory animals induced by a polyampholyte, polyethylene alanine (1980) (1)
GLIOTOXIN ANALOGS AS INHIBITORS OF REVERSE TRANSCRIPTASE. 1. EFFECT OF LIPOPHILICITY (1978) (1)
TSAO Analogues. Part 3. Synthesis and Anti-HIV-1 Activity of 2′,5′-Bis- O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl 3′-Spiro-5′′-(4′′- amino-1′′,2′′-oxathiole 2′′,2′′-dioxide) Purine and Purine-Modified Nucleosides. (1994) (1)
Structure‐Activity Relationship of Novel Oligopeptide Antiviral and Antitumor Agents Related to Netropsin and Distamycin. (1986) (1)
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity (2003) (1)
Influence of (E)-5-(2-Bromovinyl)-2′-deoxyuridine on corneal epithelium healing (2005) (1)
Interaction of TIBO and TIBO-like compounds with HIV-1 RT (1991) (1)
Design of nucleoside, oligonucleotide and polynucleotide analogues as antiviral agents. (1982) (1)
Comparative Activities of Several Nucleoside Analogs (2003) (1)
SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus (1997) (1)
Antiviral Chemistry & Chemotherapy's Current Antiviral Agents FactFile 2008 (2nd Edition): RNA Viruses (2008) (1)
Comparative Effectiveness of Oseltamivir versus Peramivir for Hospitalized Children (ages 0-5 years) with Influenza Infection. (2023) (0)
Thiosugars. Part 8. Preparation of New 4′‐Thio‐L‐lyxo Pyrimidine Nucleoside Analogues. (2002) (0)
Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents (2014) (0)
Sinteza, Strukturna Istraživanja I Biološka Ispitivanja Purinskih Derivata 1-Aminociklopropan- 1-Karboksilne Kiseline I 1-Amino-1- Hidroksimetilciklopropana (2020) (0)
A peptoid inhibitor of Tat/TAR interaction with antiviral activity (1997) (0)
Development of new anti-HIV agents and elucidation of their mechanism of action (1990) (0)
Verwendung von 5-alkylpyrimidinnukleosiden und deren derivate als zytostatika (1982) (0)
HIV-CD4 interaction as target for anti-HIV agents (1990) (0)
Contributors, Aug. 1978 (1978) (0)
HIV entry as antiviral strategy (2002) (0)
Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors (2014) (0)
Acid Related Compounds . 84 . Synthesis of 6 ’ 4 E and 2 )-Halohomovinyl Derivatives of Adenosine , Inactivation of S-Adenosyl-L-homocysteine Hydrolase , and Correlation of Anticancer and Antiviral Potencies with Enzyme Inhibition 1 (2001) (0)
Synthesis and Antiviral Activities of 8-Alkynyl-, 8-Alkenyl-, and 8- Alkyl-2′-deoxyadenosine Analogues. (1994) (0)
Editorial Review Antiviral research at the Rega Institute (KU Leuven), now 50 years old (2004) (0)
Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2023) (0)
Synthesis and chemotherapeutic activity of a carbocyclic analogue of tegafur. (1998) (0)
Differential kinetics and susceptibilities of mutagenized HIV-1 reverse transcriptases (RT) to HIV-1-specific RT inhibitors (1992) (0)
Existing Influenza Antivirals: Their Mechanisms of Action and Potential in the Face of Avian Influenza (2007) (0)
Purine Derivatives of 1,2‐Disubstituted Cyclohexane Analogues of Nucleosides. (2004) (0)
Glycopeptide antibiotic derivatives selectively inhibit human immunodeficiency virus replication in cell culture (2003) (0)
Ted-2'-deoxyuridines on the growth of human and murine tumor cell lines. (1982) (0)
The Breadth of Interferon Action (2018) (0)
Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats (1991) (0)
Intracellular metabolism of the novel anti-herpesvirus agent 2-amino-7-[1,3-dihydroxy-2-propoxy)methyl]purine compound S2242 in non-infected and herpesvirus-infected cells (1995) (0)
QSAR for Anti-RNA-Virus Activity, Synthesis, and Assay of Anti-RSV Carbonucleosides Given an Unify Representation of Spectraö Moments, Quadratic, and Topologic Indices (2005) (0)
Antiviral activity of N 4-aminocytidine derivatives related toAZT I (1994) (0)
Highly Stereoselective Synthesis and Biological Properties of Nucleoside Analogues Bearing a Spiro Inserted Oxirane Ring. (2000) (0)
Multiple Mutations in Human Immunodeficiency Virus-1 Integrase Confer Resistance to the Pyranodipyrimidine V-165 (2004) (0)
Thymidine phosphorylase is non-competitively inhibited by 5’-O-trityl-inosine (KIN59) and related compounds (2005) (0)
Microwave-Assisted Synthesis and anti-HIV Activity of New Acyclic C-Nucleosides of 3-(D-ribo-Tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1. (2008) (0)
Aromatic polycationic molecules with restricted conformations: An alternative approach to antiherpes agents (2005) (0)
Synthesis, Influence of Polymer Molecular Weight on Drug Release and Anti-HIV Activity of PEGylated AZT Conjugates (2011) (0)
Activity of several inhibitors of S-adenosyl homocysteine hydrolase against African swine fever virus (1991) (0)
An Intriguing and Facile One‐Pot Catalytic Synthesis of N‐Alkylated Lactams. (2013) (0)
Successful treatment of severe anogenital papillomavirus infections in AIDS patients with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (1995) (0)
High level expression of HIV-1 integrase in eukaryotic cells (1998) (0)
Modulation of transport of Bis(POM)-PMEA and efflux of its metabolites by two distinct carrier mechanisms in Caco-2 cells (1997) (0)
Therapeutic strategies for COVID-19: progress and lessons learned (2023) (0)
Synthesis of Unusual Bicyclic Nucleosides Bearing an Unsaturated Side-Chain, as Potential Inhibitors of Varicella—Zoster Virus (VZV) (2004) (0)
A study of the diffusion of HIV-1 integrase, EGFP and DNA inside HeLa cells with fluorescence correlation microscopy (2001) (0)
5'-O-Phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity (1990) (0)
Interaction of HIV-1 integrase with human integrase interactor 1 (INI1) in vivo (2002) (0)
Synthesis and Biological Evaluation of Phosphonate Derivatives of Some Acyclic Pyridine-C-nucleosides. (1999) (0)
Nucleoside Analogues in the Chemotherapy of Viral Infections (1988) (0)
HPMPC: A new antiviral agent with activity against human papillomavirus (1994) (0)
Inhibition of HIV-1 replication and integrase activity by a series of diketo derivatives (2001) (0)
Concert chromatography purification of mouse interferon [proceedings]. (1979) (0)
Synthesis and antiviral evaluation of 9-(RS)-[2-phosphonylmethoxy-3-(2-propoxy)propyl]adenine (1991) (0)
Poly (G). Poly (C) As an Inducer of Interferon (1984) (0)
75 Mouse models for the evaluation of antiviral and immunotherapy in the treatment of systemic adenovirus infections (2006) (0)
CMV423, a potent and selective inhibitor of human herpesvirus 6 exerts its antiviral action through inhibition of cellular protein tyrosine kinase activity (2003) (0)
Treatment of HIV-infected cell cultures with high concentrations of anti-HIV drugs for several days does not prevent resumption of virus production upon removal of the antivirals (1998) (0)
Adducts of 3'-azido-2',3'-dideoxythymidine 5'-phosphate or 5'-hydrogenphosphonate as inhibitors of retrovirus replication in cell culture (1993) (0)
Potential chemotherapeutic targets in the replicative cycle of HIV (1994) (0)
Anti-herpesvirus chemotherapy: experimental and clinical aspects. Concluding remarks. (1979) (0)
Genotypic characterization of various herpes simplex virus type 1 (HSV-1) clones resistant to acyclic nucleoside phosphonates (1997) (0)
[Isolation and in vitro and in vivo characteristics of a clone of a wild Aujeszky disease virus resistant to bromovinyldeoxyuridine]. (1989) (0)
Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine. (1991) (0)
Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability (2022) (0)
Mycophenolate Mofetil markedly enhances the antiviral activity of acyclovir, ganciclovir and penciclovir against herpes simplex virus (wild type and TK− strains) and human cytomegalovirus (1997) (0)
Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleosides Analogues. (2005) (0)
Potent and selective anti-retrovirus activity of 9-(RS)-(3-fluoro-2-phosphonylmethoxypropyl) purine derivatives (1991) (0)
[Acyclic nucleotide analogues based on phosphonic acids]. (1998) (0)
Evaluation of CXCR4 inhibitors by FLIPR and flow cytometric techniques (2002) (0)
Synthesis of 5'-N-(alpha-amino-beta-mercaptoacyl)amino-5'-deoxynucleosides as potential antiviral compounds. (1991) (0)
Selection of antiviral resistance against diketo derivatives, authentic inhibitors of HIV-1 integration (2001) (0)
Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES) (2007) (0)
Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations (2008) (0)
A new family of non-nucleoside inhibitors of human cytomegalovirus (HCMV) and varicella-zoster virus (VZV) based on the beta-keto-gamma-sultone template (2005) (0)
Interactions of antiviral agents with viral DNA synthesis (1988) (0)
Composés de pyrimidine à groupes phosphonate, en tant qu'analogues nucleotidiques antiviraux (2004) (0)
New Analogues of Acyclovir Substituted at the Side Chain (2008) (0)
Resolution of Alfisteromycin Enantiomers. (1986) (0)
Viruses and Viral Diseases (2007) (0)
Pyridazines. Part 92. Synthesis of Dialkyldipyridazinodiazepinones as Potential HIV-1 Reverse Transcriptase Inhibitors. (2010) (0)
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. (1985) (0)
Quinolone Nucleosides: 6,7‐Dihalo‐N‐β‐ and α‐Glycosyl‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic Acids and Derivatives. Synthesis, Antimicrobial and Antiviral Activity. (1999) (0)
Synthesis and Antiviral Evaluationof (-)-3′-Methylcarbovir, (-)-3′-Methylabacavir,and Modified Purine Analogues (2009) (0)
Synthesis and biological evaluation of novel mononuclear Ru(II) compounds as potential antiviral and cytotoxic agents (2016) (0)
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged albumins and AZT (1998) (0)
Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability (2023) (0)
Optimization of experimental conditions to study intestinal transport of the antiviral agent UC-781 (2000) (0)
Novel TSAO Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues. (1996) (0)
N-aminoimidazole derivatives inhibit HIV-1 gene expression by an unexploited mechanism of action (2006) (0)
Composes heterocycliques destines a etre utilises dans le traitement d'infections virales (2004) (0)
Characterization of drug-resistant herpes simplex virus type 1 (HSV-1) mutants obtained under single-round selection with high-dose brivudin (BVDU) (2002) (0)
61: In vitro selection and characterization of human herpesvirus 6 strains resistant to foscarnet or cidofovir (2006) (0)
Synthesis and Antiviral Activities of Some New 5‐Heteroaromatic Substituted Derivatives of 2′‐Deoxyuridine. (2010) (0)
Anti-HIV Agents Interfering with the Viral gp120-Cellular CD4 Interaction (1992) (0)
Synthesis and anti‐HIV‐1 and anti‐HCMV Activity of 1‐Substituted 3‐(3,5‐Dimethylbenzyl)uracil Derivatives. (2006) (0)
Synthesis and anti-HIV evaluation of new 2-Thioxoimidazolidin-4-ones and their Arylidine (styryl) derivatives (2012) (0)
SAR of monosubstituted phenyl furano pyrimidine as potent and selective anti Varicella-Zoster Virus (VZV) compounds (2006) (0)
Unusual Lability of 5′-O-tert-Butyldimethylsilyl Group on 4′′-Acyl TSAO Derivatives (2004) (0)
Solvent-Free Synthesis of Pyrimidine Nucleoside-Aminophosphonate Hybrids and Their Biological Activity Evaluation. (2011) (0)
The inability of flaviviruses with a not known vector to replicate in mosquito cells is not determined by the viral envelope proteins (2006) (0)
Characterization of the DNA polymerase genes of varicella-zoster virus (VZV) resistant to foscarnet (PFA) and the 2-phosphonomethoxyethyl (PME) derivatives of adenine (Adefovir, PMEA) and 2,6-diaminopurine (PMEDAP) (2004) (0)
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES. (2016) (0)
The synthesis of novel phospholipids with potential antineoplastic and antiviral activity (1995) (0)
HIV-1 integrase inhibitors monitored with surface plasmon resonance technology (1996) (0)
Combination of the multidrug resistance mutation Q151M/L and the AZT resistance mutation T215Y/F in the same HIV-1 reverse transcriptase is compatible with enzymatic activity (1998) (0)
Synthesis and biological evaluation of a new series of 5-alkylaryl nucleoside analogues showing anti-HCMV activity (2003) (0)
Pd-Catalyzed Synthesis of C4-Aryl Pyrimidinone Nucleoside Analogues (2007) (0)
Inhibitory Effects ofAntiviral Compounds on Respiratory Syncytial VirusReplication InVitro (1987) (0)
Effect of (E)-5-(2-Bromovinyl)-2′-deoxyuridine on the Growth and Viral Capsid Antigen Expression of Epstein-Barr Virus-Associated Tumor (B-95-8) Cells Transplanted to Nude Mice (1985) (0)
QUANTIFICATION OF HIV-1 RNA IN PLASMA USING THE NASBA(R) AMPLIFICATION SYSTEM COMPARED TO AN IN-HOUSE QUANTITATIVE RNA-PCR AND THE AMPLICOR(R) HIV MONITOR TEST (1995) (0)
Characterization of varicella-zoster virus (VZV) mutants resistant to bicyclic pyrimidine nucleoside analogues (BCNAs) (2003) (0)
Inhibition of the metabolism of ester prodrugs in view of a modulation of their intestinal absorption (2000) (0)
Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of Hiv Infection (2003) (0)
Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide). (1993) (0)
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxathiole-2",2"-dioxide)]-f8-D-pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhib (2005) (0)
SYNTHESIS AND ANTIVIRAL ACTIVITIES OF NEW 5-SUBSTITUTED PYRIMIDINE NUCLEOSIDE ANALOGS (1980) (0)
5-Quinone Derivatives of 2′-Deoxyuridine 5′-Phosphate: Inhibition and Inactivation of Thymidylate Synthase, Antitumor Cell, and Antiviral Studies. (1987) (0)
The substituted imidazopyridine GS-327073 is a potent inhibitor of HCV replication (2007) (0)
Synthesis and Antiproliferative Activity of 2′‐O‐Allyl‐1‐β‐D‐ arabinofuranosyl‐uracil, ‐cytosine and ‐adenine. (1997) (0)
Benzothiadiazine Dioxide Acyclonucleosides as Lead Compounds for the Development of New Agents Against Human Cytomegalovirus and Varicella‐ Zoster Virus Infections. (1997) (0)
The Synthesis, Cytostatic and Antiviral Evaluations of The Novel C-5 Substituted Pyrimidine and Purine Derivatives of L-ascorbic Acid (2005) (0)
N′‐[4‐[(Substituted imino)methyl]benzylidene]‐substituted Benzohydrazides: Synthesis, Antimicrobial, Antiviral, and Anticancer Evaluation, and QSAR Studies. (2013) (0)
Use of heparin fractions or heparin fragments. (1989) (0)
Synthesis of 1-(2-Deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: “Thymine Replacement” Analogues of Thymidine for Evaluation as Anticancer and Antiviral Agents. (2001) (0)
Immune repertoire sequencing reveals an abnormal adaptive immune system in COVID‐19 survivors (2022) (0)
Synthesis, conformation and anti-HIV activity of 3'-substituted 2',3'-dideoxy-5-hydroxymethyluridines (1993) (0)
Compliance is significantly better in HAART responders compared to non-responders (2000) (0)
Synthesis, 18F‐Radiolabelling and Biological Evaluations of C‐6 Alkylated Pyrimidine Nucleoside Analogues. (2005) (0)
Specificity Neurotropism Independent of Coreceptor from Brain and Lymphoid Tissues Predicts Immunodeficiency Virus Type 1 Isolates Macrophage Tropism of Human (2001) (0)
Although the bicyclic nucleoside analogues (BCNAs) are highly active against varicella-zoster virus (VZV), they are inactive against simian varicella virus (SVV) despite efficient phosphorylation of the BCNAs by SVV-encoded thymidine kinase (2004) (0)
Synthesis and Antiviral Activity of Carbocyclic Oxetanocin Analogues ( C‐OXT‐A, C‐OXT‐G) and Related Compounds. Part 2. (1994) (0)
Antiviral Activity of Reverse Transcriptase Inhibitors against Porcine Endogenous Retroviruses (PERV) (2007) (0)
Structure-activity relationships studies in TSAO-T derivatives modified at the 2′- and 5′- positions of the sugar moiety (1995) (0)
The TIBO-site on HIV-1 reverse transcriptase represents a new target for anti-HIV chemotherapy (1991) (0)
The multi-nucleoside resistance phenotype characterised by the Q151M mutation in the HIV-1 reverse transcriptase is enhanced under the selective pressure of acyclic nucleotide analogs but reduced by foscarnet (2000) (0)
The anti-HIV activity of the CXCR4 inhibitor AMD3100 is independent of the CXCR4/HIV coreceptor level (2003) (0)
A novel class of HIV inhibitors that target the cellular CD4 receptor (2004) (0)
Synthesis and Anti‐HIV‐1 Activity of 4‐ and 5‐Substituted 1,2,3‐ Triazole‐TSAO Derivatives. (1995) (0)
Future applications of oligonucleotides in antiviral and antitumoral chemotherapy (1992) (0)
Proceedings: Inhibition of mouse leukemia virus RNA-dependent DNA polymerase by 2'-OH-substituted polynucleotides. (1974) (0)
The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, cytostatic and antiviral evaluations (2004) (0)
New Antiviral Drugs for the Treatment of Herpesvirus Infections (1985) (0)
∆F13L-GFP-Vac (p37-deleted vaccinia virus) is attenuated in mice and protects against infection with wild-type virus (2006) (0)
Synthesis, Structural Studies And Biological Evaluation Of The Purine Substituted 1- Aminocyclopropane-1-Carboxylic Acids And 1-Amino- 1-Hydroxymethylcyclopropanes (2003) (0)
3′-C-Trifluoromethyl Ribonucleosides. (1995) (0)
(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity. (1978) (0)
The viral load of a divergent clinical HIV-1 strain can only be quantified by the branched DNA assay (1997) (0)
Differing SARs and MOAs emerge for the highly potent anti-VZV, BCNAs, and their anti-HCMV dd analogues (2004) (0)
Synthesis, Protonation Behavior, Conformational Analysis, and Regioselective Enzymatic Acylation of the Novel Diamino Analogue of (E)‐5‐(2‐Bromovinyl)‐2′‐deoxyuridine (BVDU). (2004) (0)
Carbocyclic 7-Deazaguanine Oxetanocin Analogues. (1998) (0)
The Next Ten Stories on Antiviral Drug Discovery. Part E. Advents, Advances, and Adventures (2011) (0)
Phosphoramidate derivatives of carbocyclic L-d4A nucleosides and related analogues (2003) (0)
Abstracts of papers Symposium “new therapeutic developments in human infectious diseases” (1989) (0)
Synthesis and anti‐HIV Activity of Some New Aminoadamantane Heterocycles. (2010) (0)
Synthesis of 1,5‐Anhydrohexitol Nucleosides as Mimics of AZT, D4T, and DDC. (1996) (0)
Antiviral activity of different anti-herpesvirus compounds on keratinocyte organotypic cultures infected with herpes simplex virus and varicella-zoster virus (2000) (0)
New derivatives of 3 (premium) azido-3 (premium) deoxythymidine (azt) active against the AIDS virus hiv (1988) (0)
Unusual tricyclic nucleosides derived from TSAO-T with activity against human immunodeficiency virus type-1 (2005) (0)
Designing Novel Hydrazinecarbothioamides as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (2017) (0)
N-fosfonilmetoxialquilicos derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions based thereon, with antiviral activity. (1987) (0)
Corrigendum to “Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents” [Tetrahedron 54 (1998) 2209] (1998) (0)
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A colorimetric cell culture assay for the identification of SARS coronavirus inhibitors (2004) (0)
ACYCLIC NUCLEOTIDE ANALOGUES ON THE BASIS OF PHOSPHONIC ACIDS (1998) (0)
Potent antitumor activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in choriocarcinoma-bearing rats (1997) (0)
Potent and highly selective HIV-1 specific inhibition by a new series of alfa-anilino phenyl acetamide (alfa-APA) derivatives targeted at HIV-1 reverse transcriptase (1992) (0)
Effect of cidofovir on the tumor growth of SiHa (human cervical carcinoma) cells in nude mice (1997) (0)
Collinone, a New Recombinant Angular Polyketide Antibiotic Made by an Engineered Streptomyces Strain (2001) (0)
Chapter 1 Looking Back in 2009 at the Dawning of Antiviral Therapy Now 50 Years Ago (2009) (0)
Antivirals & Other Treatments56: Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts (2006) (0)
Heparin fragments and fractions with anti-HIV effect (1989) (0)
Thiocarboxanilides: A New Class of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) with Great Potential for the Treatment of Human Immunodeficiency Virus Type 1 (HIV-l) Infections (2008) (0)
Binding of fluorescent oligonucleotides to HIV-1 integrase using fluorescence fluctuation analysis: oligonucleotides induce oligomerization (2001) (0)
Cyclotriazadisulfonamide (CADA) compounds, HIV entry inhibitors that specifically target the cellular CD4 receptor (2006) (0)
Bicyclic furo pyrimidine nucleosides with haloaryl side chains (2003) (0)
Inhibition of cytomegalovirus replication by acyclic nucleoside phosphonate analogues: structure-activity relationship (1991) (0)
Acyclic/Carbocyclic Guanosine Analogues as Anti‐Herpesvirus Agents (2001) (0)
Absorption of the bis(Pivaloyloxymethyl)ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine across rat intestine in ussing chambers (1998) (0)
Derivatives of glycopeptide antibiotics with anti-retroviral activities (2003) (0)
Receptor MDCChemokine ( MDC ) Imply an Additional-Terminally Processed Macrophage-Derived 2 and Altered Chemotactic Potency of NH Cutting Edge : Enhanced Anti-HIV-1 Activity (1998) (0)
Synthesis, structure and some biological properties of 3'-C-branched 2'-deoxythymidines and their 5'-phosphate derivatives (1992) (0)
Conceptually new thymidine phosphorylase inhibitors with anti-angiogenic activity (2003) (0)
Novel Aryl Substituted Bicyclic Furo Nucleosides as Extremely Potent and Selective Anti‐VZV Agents (2001) (0)
The Novel C-6 Alkylated Pyrimidine Derivatives: Synthesis, X-Ray Crystal Structure Study, Antiviral and Cytostatic Evaluations (2004) (0)
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Isoxazolidine Analogues of Nucleosides. (1993) (0)
The anti-HIV and anti-HHV-7 potency of CADA analogs is strictly correlated with their ability to down-modulate the CD4 receptor (2002) (0)
Antiviral active adenine derivatives, their use and process for their manufacture (1984) (0)
The development of BVDU: An odyssey (2023) (0)
Analogues of TSAO-T as the First Sugar Derivatives That Specifically Inhibit HIV-1 Reverse Transcriptase (1998) (0)
A therapeutic composition for the treatment of viral diseases (1986) (0)
Synthesis and Antiviral Activity of 3′-C-Cyano-3′-deoxynucleosides. (1990) (0)
The assessment of the broad spectrum in vitro antiviral activity of a series of organogermanium compounds (1991) (0)
Human immunodeficiency virus gp120 as the primary target of action of AR177 (Zintevir) (1997) (0)
EVIDENCE FOR THE INVOLVEMENT OF THE SMALL SUBUNIT OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN THE TSAO-RESISTANCE (1995) (0)
Development of resistance of human immunodeficiency virus type 1 and 2 against the PETT derivative MSK-076 (2003) (0)
C-1 Antiviral activity of acyclic and cyclic nucleoside phosphonates (2009) (0)
Nucleosides and Nucleotides. Part 149. New Neplanocin Analogues. Part 7. Synthesis and Antiviral Activity of 2-Halo Derivatives of Neplanocin A. (1997) (0)
Cidofovir Tumor Formation by the Acyclic Nucleoside Phosphonate Inhibition of Fibroblast Growth Factor-2-induced Vascular Updated (2001) (0)
Hamao Umezawa Memorial Award Lecture1 (2001) (0)
TIBO derivatives represent a new lead of potent and selective HIV-1 inhibitors that interact with a reverse transcriptase-associated process (1990) (0)
Ofaseries ofcarbocyclic analogs ofadenosine, inwhichtheribose moiety was replaced bya cyclopentenyl ring, neplanocin A,or (-)-9-(trans-2, trans-3-dihydroxy-4-(hydroxymethyl)cyclopent-4-enylJadenine (1985) (0)
Permeability of the Cornea to (125I)IVDU, an Analogue of Bromovinyldeoxyuridine (1985) (0)
Synthesis and Antiviral Activity of Imidazo[1,2-a]pyridines. (1999) (0)
Different prevalences of resistance-related mutations in treatment-naïve patients carrying HIV-1 subtype B compared to other subtypes (2001) (0)
Activity of hydroxyurea (HU) in combination with several antiviral nucleosides against in vitro replication of herpes simplex type 1 (HSV-1) and type 2 (HSV-2) and varicella-zoster virus (VZV) (1995) (0)
Synthesis of Novel 5′-Substituted TSAO-T Analogues with anti-HIV-1 Activity. (2000) (0)
5-SUBSTITUTED URACIL ARABINONUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS (1979) (0)
Synthesis and Anti‐HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore Through Methylene and Amide Linkers. (1999) (0)
Highly selective and potent inhibition of human immunodeficiency virus (HIV) by the novel bicyclam derivative JM3100 (1993) (0)
Synthesis of Novel Carbocyclic Nucleosides with a Modified Cyclopentane Ring and Evaluation of Their Antiviral Activity (1999) (0)
Studies into the Synthesis of Derivatives of 4-Amino-2,3-dihydroisothiazole 1,1-Dioxides and 4-Amino-1,2-oxathiole 2,2-Dioxides: The Search for Linked π-System Containing Analogues as Potential Inhibitors of HIV-1 Reverse Transcriptase. (2010) (0)
Synthesis and Antiviral Activity of 3′‐Heterocyclic Substituted 3′‐Deoxythymidines. (1990) (0)
Investigation of the synthesis of some acyclic pyridine C-nucleosides. Part one (1994) (0)
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators (2022) (0)
Keratinocyte organotypic cultures as a model for studying viral infections (2000) (0)
Synthesis, antiviral activity, and cytotoxicity of some novel quinazolin-4 (3h)-one derivatives (2006) (0)
Interactions of the dimeric triad of HIV-1 aspartyl protease with inhibitors. (2003) (0)
Resistance of HIV-1 RT to TIBO derivatives induced by site-directed mutagenesis (1992) (0)
Site-specific degradation of the antiviral agent bis(isopropyloxymethyloxycarbonyl)-9-(2-phosphonylmethoxypropyl)adenine (1998) (0)
Gene transfer into neuronal cells using lentiviral vectors (1999) (0)
Transduction efficiency of HIV-1 derived lentiviral vectors in T-cell lines, primary macrophages and hematopoietic stem cells (2001) (0)
A N-propionylsulfonamide prodrug of K-5a2 provided improved aqueous solubility and hERG inhibition (2020) (0)
Diaryl Phosphate Derivatives Act as Pro-Drugs of AZT with Reduced Cytotoxicity Compared to the Parent Nucleoside. (1994) (0)
Synthesis and Biological Activity of Some 2-Aminopurine Carbonucleosides. (1998) (0)
CXCR4 antagonists as HIV entry inhibitors (2001) (0)
Correlation between the anti-HIV potency of CADA derivatives and their ability to down-modulate the CD4 receptor (2002) (0)
Synthesis, characterization and biological evaluation of 1,3-thiazolidine-4-ones derived from (2S)-2-benzoylamino-3-methylbutanohydrazide hydrazones (2021) (0)
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Mouse adenovirus type 1-infected SCID mice: a unique model for the evaluation of antiviral compounds against systemic adenovirus infections (2005) (0)
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Antiviral Chemotherapy: Potential Drugs for the Treatment of Severe Virus Infections (1987) (0)
Establishment of an in vitro assay system for HIV-1-induced neural cell death and inhibition thereof (2002) (0)
Antiviral Agents in the Treatment of Herpes Virus Infections in Immunosuppressed Patients (1987) (0)
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The anti-HIV activity of 2′, 3′-dideoxyadenosine analogues in vitro (1987) (0)
25th Anniversary Lecture: Success and failure in antiviral drug development; personal reminiscences with a Japanese connection (2012) (0)
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Expansion of the S-CN-DABO Scaffold to Exploit the Impact on Inhibitory Activities Against the Non-Nucleoside HIV-1 Reverse Transcriptase (2022) (0)
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(S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC), a potent and selective inhibitor of cytomegalovirus infection in vitro and in vivo (1991) (0)
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Synthesis and Anti Hiv-1 Reverse Transcriptase Evaluation of A Series of N-Mono Substituted Thiourea Derivatives (2015) (0)
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5-Phosphoribosyl 1-Pyrophosphate Synthetase Converts the Acyclic Nucleoside Phosphonates 9-(3-Hy-droxy-2-phosphonylmethoxypro- py1)adenine and 9-(2-Phosphonyl-methoxyethy1)adenine Directly to Their Antivirally Active Diphosphate Derivatives* (2001) (0)
Study of Different Substituted Cyclic and Acyclic Benzylpronucleotides of d4T Relative to Their Hydrolytic Stability and Antiviral Activity (2003) (0)
Novel TSAO Derivatives Modified at Positions 3′′ and 4′′ of the Spiro Moiety (1999) (0)
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Drug susceptibility profiles of recombinant vaccinia virus harboring mutation(s) conferring resistance to cidofovir (2006) (0)
Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides. (1996) (0)
GLIOTOXIN ANALOGS AS INHIBITORS OF REVERSE TRANSCRIPTASE. 2. RESOLUTION AND X-RAY CRYSTAL STRUCTURE DETERMINATION (1978) (0)
Synthesis of acyclic nucleotide analogues derived from 2-(aminomethyl)purine bases (1995) (0)
ChemInform Abstract: Uracil Derivatives and Analogues. Part 21. Palladium-Catalyzed Synthesis of (E)-5-(2-Acylvinyl)-2′-deoxyuridines and Their Antiviral and Cytotoxic Activities. (1995) (0)
HIV-1 strains resistant to mannose- and N-acetylglucosamine-binding proteins show mutations at glycosylation sites of gp120 (2005) (0)
Use of Caco-2 monolayers to study intestinal transport and metabolism of an ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine (1996) (0)
S-Adenosyl-L-Homocysteine Hydrolase as Target Enzyme for Antiviral Agents: Studies with Adenosine Kinase-Deficient Rat Cells (1987) (0)
Mechanism of anti-human immunodeficiency virus (HIV) action of selected ATA-polymer analogues (1995) (0)
Precast, prestressed SCC beams with high-strength prestressing strands (2005) (0)
Synthesis and fluorescent properties of the tricyclic analogues of acyclovir linked with nitrogen heteroaryl units (2004) (0)
Synthesis, Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 2. Adenosine and Uridine Analogues. (1998) (0)
Oligomeric state of HIV-1 in: stable integrase, tetramers in human cell (2002) (0)
N-Aminoimidazole derivatives with anti-HIV activity: synthesis and biological evaluation (2002) (0)
DRUG SYNTHESIS SYNTHESIS AND ANTI-HIV ACTIVITY OF NOVEL 3-SUBSTITUTED PHENYL-6 , 7-DIMETHOXY-3 a , 4-DIHYDRO-3 H-INDENO [ 1 , 2-c ] ISOXAZOLE ANALOGUES (2011) (0)
Allosteric inhibition of endogenous HIV-1 reverse transcription by TIBO derivatives (1992) (0)
Thymidylate Synthetase-Positive and -Negative Mouse Mammary Carcinoma Cell Lines: Useful Model for Monitoring the Incorporation of Pyrimidine Nucleoside Analogues into Host Cell DNA and for Detecting Thymidylate Synthetase Inhibitors (1985) (0)
Protein-protein interactions during HIV-1 replication revealed by chemical cross-linking (1996) (0)
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs. (2022) (0)
First Example of a 4-Amino-1,2,4,6-thiatriazine 1,1-Dioxide Derivative. (1997) (0)
Site-directed mutagenesis of HIV-1 reverse transcriptase (1991) (0)
SYNTHESIS AND ANTIVIRAL ACTIVITY OF 5-((CYANOMETHYLENE)OXY)-2′-DEOXYURIDINE (1981) (0)
Discovery and development of TIBO as a potential anti-AIDS therapeutic (1992) (0)
Synthesis of 3′-Azido-2′,3′-dideoxy-6-methyluridine (VI), 2′,3′-Dideoxy-6-methyluridine (IX) and 2′,3′-Dideoxy-2′,3′-didehydro-6-methyluridine (1990) (0)
The HIV-1 cPPT/CTS fragment mediates efficient transgene expression from lentiviral vectors (2002) (0)
Therapeutic Implications of the Unusually Long Half-Life of (E)-5-(2-BRO-Movinyl)Uracil (BVUra) in Vivo (1985) (0)
Synthesis and Antiviral Activity of Acyclic Derivatives of 5-Ethyl-2′- deoxyuridine. (1986) (0)
Fluorescence correlation microscopy study of protein interactions in the cell (2004) (0)
2′-C-Alkoxy and 2′-C-Aryloxy Derivatives of N-(2-Phosphonomethoxyethyl)purines and -pyrimidines: Synthesis and Biological Activity. (2002) (0)
OXIME AND DITHIOLANE DERIVATIVES OF 5-FORMYL-2′-DEOXYURIDINE AND THEIR 5′-PHOSPHATES: ANTIVIRIAL EFFECTS AND THYMIDYLATE SYNTHETASE INHIBITION (1980) (0)
Highly potent and selective inhibitors of varicella zoster virus based on p-alkyloxyphenyl bicyclic furo pyrimidines (2002) (0)
198 Synthesis and antiviral evaluation of imidazo[1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives (1993) (0)
Selective inhibitory effect of a TIBO compound, R82150, on the activity of HIV-1 reverse transcriptase (1991) (0)
Molecular Modeling Studies: Discovery of Novel Potent Non-Nucleoside RT Inhibitors (2007) (0)
Synthesis and Antiviral Evaluation of Several 6-(Methylenecarbomethoxy)pteridine-4,7(3H,8H)-diones. (1999) (0)
5-Substituted 2'-deoxyuridines which selectively inhibit herpes simplex virus replication. (1979) (0)
Synthesis and Biological Evaluation of 2-(2-Deoxy-β-D- ribofuranosyl)pyridine-4-carboxamide. (1992) (0)
Abstracts of oral presentations (2005) (0)
Antiviral chemotherapy today and tomorrow. (1988) (0)
Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation) (2022) (0)
Pharmacological properties of the novel anti-varicella-zoster virus bicyclic nucleoside analogues (BCNAs) (2002) (0)
Hope and hype (2006) (0)
Antiviral effect on infectious pancreatic necrosis virus replication (1995) (0)
Evaluation of chemokine receptor antagonists: comparing FLIPR and flow cytometric techniques (2002) (0)
Synthesis of 3'-azido-2,3-dideoxynucleosides and 3'-fluoro-2',3'-dideoxynucleosides with a purine base and determination of their anti-hiv activity (1988) (0)
Derivatives of 6- [2- (phosphonomethoxy) alkoxy] pyrimidine compounds having antiviral activity (2002) (0)
Combination of azidothymidine (AZT) with (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) leads to inhibition of the in vitro replication of herpes simplex virus type 1 (HSV-1), type 2 (HSV-2) and varicella-zoster virus (VZV) strains that are deficient in thymidine kinase (TK) activity (1995) (0)
CADA, a novel antiretroviral drug with specific CD4 down-modulating activity (2002) (0)
Antimicrobial agents: viral (1989) (0)
9-(2-Aryloxyethyl) Derivatives of Adenine — A New Class of Non-Nucleosidic Antiviral Agents. (2004) (0)
Synthesis and Antiviral Activity of 3‐Substituted Imidazo(1,2‐a) pyridines. (1995) (0)
Transient heat transfer for boiling water at a vertical plate of a reactor pressure vessel (1973) (0)
Activity of 7,8-dihydro-isoquinoline-6-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide hydrochloride salt against human cytomegalovirus (HCMV) (2002) (0)
Site-specific and species-dependent intestinal metabolism of the ester prodrug Bis(isopropyloxycarbonyloxymethyl)-(R)-9-(2-phosphonomethoxypropyl)adenine (1999) (0)
THE INFLUENCE OF ARTIFICIAL ROUGHNESS ON THE INCREASE IN THE CRITICAL HEAT FLUX OF WATER IN RING GAPS UNDER FORCED CONVECTION. PART I. UNDERCOOLED STATE AT MEASURING SECTION OUTLET. (1968) (0)
Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is suitable for high-throughput evaluation of HIV/coreceptor inhibitors (2004) (0)
ANTHRACYCLINONES. PART 1. A VERSATILE SYNTHESIS OF THE ANTHRACYCLINONE SYSTEM M USING A CHIRAL TEMPLATE DERIVED FROM A CARBOHYDRATE (1983) (0)
HIV-1 specific phenylacetamide derivatives: a novel class of reverse transcriptase inhibitors with potent and selective antiviral activity in vitro (1992) (0)
Synthesis, X-ray crystal structure study and biological evaluation of the novel cycloalkyl-N-aryl substituted hydroxamic acids (2003) (0)
Anti-HIV agents to be used in drug combination regimens (2004) (0)
Antiviral Research at the Rega Institute (KU Leuven), Now 50 Years Old (2004) (0)
Epidemiology and Clinical Outcomes of HIV Infection in South-Central China: A Retrospective Study From 2003 to 2018 (2022) (0)
Interferon Induction by Synthetic Polynucleotides: Importance of Purine N-7 and Strandwise Rearrangement (primary rabbit kidney cells/vesicular stomatitis virus/poly(I) poly(C)/poly(A) poly(U)) (2016) (0)
Anti-HIV activity profile of a highly specific CD4 receptor down-modulating compound (2003) (0)
Interaction of the bicyclic nucleoside analogues (BCNAs) with human varicella-zoster virus (VZV) and simian varicella virus (SVV) thymidine kinase and VZV DNA polymerase (2003) (0)
The Synthesis, Fluorescence and Antiviral Studies of 3′-Amino-2′,3′-Dideoxythymidine/substituted 10-Cyano-9-isothiocyanatoanthracene Adducts (1994) (0)
Perspectives for the chemotherapy of AIDS. (1987) (0)
Antiviral research at the Rega Institute (KU leuven), now 50 years old. (2004) (0)
Synthesis, Conformation Analysis and Biological Evaluation of 2-(2,3- Dideoxy-β-D-ribofuranosyl)pyridine-4-carboxamide. (1996) (0)
Phosphoramidate Derivatives of 2′,3′‐Didehydro‐2′,3′‐dideoxyadenosine ( d4A) Have Markedly Improved Anti‐HIV Potency and Selectivity. (1997) (0)
Mononuclear cells as a transfer vehicle for herpes simplex virus (HSV) or vaccinia virus (VV) infection of epithelial cells grown in 3D (2007) (0)
Synthesis, Antiviral and Cytostatic Activities, of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 4. Adenosine and Uridine Analogues. (2010) (0)
Synthesis, Cytostatic and Antiviral Evaluations of the New C-5 Substituted Pyrimidine and Furo[2, 3-d]pyrimidine 4, 5-Didehydro-L-ascorbic Acid Derivatives (2008) (0)
Naphthalenedisulfonic acid derivatives inhibit HIV-1-induced cytopathogenesis, syncytia formation and virus-cell binding by interaction with the viral envelope glycoprotein (1993) (0)
Infection of different human tumor cell lines by human cytomegalovirus (1991) (0)
Highly efficient in vitro integration by the integrase of the human immunodeficiency virus type 1 using a novel DNA substrate (1997) (0)
SYNTHESIS OF 5‐((METHYLTHIO)METHYL)‐2′‐DEOXYURIDINE, THE CORRESPONDING SULFOXIDE AND SULFONE, AND THEIR 5′‐PHOSPHATES: ANTIVIRAL EFFECTS AND THYMIDYLATE SYNTHETASE INHIBITION (1980) (0)
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. (2023) (0)
[Penetration and action of edoxudine in vitro and in vivo]. (1989) (0)
Synthesis and Biological Activity of 4-Substituted 1-[1-(2-Hydroxyethoxy)methyl-1,2,3-triazol-(4 and 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines. (2002) (0)
Antiviral Research: Strategies in Antiviral Drug Discovery. Edited by Robert L. LaFemina. Washington (DC): ASM Press. $169.95. xiii + 373 p. + 29 pl.; ill.; index. ISBN: 978-1-55581-439-7. 2009. (2011) (0)
Synthesis of 1‐(2‐Deoxy‐β‐D‐ribofuranosyl)‐2,4‐difluoro‐5‐substituted‐benzene Thymidine Mimics, Some Related α‐Anomers, and Their Evaluation as Antiviral and Anticancer Agents. (2001) (0)
Cidofovir for the Treatment of Molluscum Contagiosum Virus (2022) (0)
Synthesis and anti‐HIV Activity of Thymidine Analogues Bearing a 4′‐Cyanovinyl Group and Some Derivatives Thereof. (2002) (0)
Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate. (2010) (0)
Disulfide-containing macrolides that inhibit a late stage of the replicative cycle of human immunodeficiency virus (1997) (0)
TIBO derivatives: a new class of potent and selective inhibitors of HIV-1 replication (1991) (0)
Chemotherapy of human immunodeficiency virus (HIV) infection based on chemotherapeutic intervention with early steps of the virus replicative cycle. (1995) (0)
Incorporation of carbocyclic (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) into DNA of herpes simplex virus-infected cells. (1985) (0)
Thiazolobenzimidazoles as potent inhibitors of the in vitro replication of Coxsackie B virus (2006) (0)
Interferon inducers. (1980) (0)
The Elegance of the Acyclic Nucleoside Phosphonates (ANPs), Honorary Tribute to Antonín Holý, Who Passed Away on 16 July 2012, at the 10th Anniversary of His Death (2022) (0)
Anti-HIV, antimycobacterial and antimicrobial studies of newly synthesized 1,2,4-triazole clubbed benzothiazoles (2012) (0)
Novel Analogues of the anti HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety. (1998) (0)
Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction (2022) (0)
The pharmaceutical composition and method for the treatment of retroviral infections (2001) (0)
Thiosugars. Part 5. Synthesis and Biological Activity of 1-(4-Thio-L-arabinofuranosyl)-5-halopyrimidine Nucleosides. (2000) (0)
2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5 (2007) (0)
[Highly specific inhibitors of human immunodeficiency virus type I that are particularly targeted at the reverse transcriptase]. (1993) (0)
The influence of cyclosporin and corticosteroids on HBV replication in primary cultures of human hepatocytes (1998) (0)
Gender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period (2022) (0)
Synthesis and Antiviral Activities of Novel Purinyl-and Pyrimidinylcarbanucleosides Derived from Indan 1 (2008) (0)
Virulence Evolves In Vivo , Leading to Increased Immunodeficiency Virus with Nef Deleted Coreceptor Phenotype of Natural Human (2002) (0)
Enhanced Inhibition of HIV‐1 Replication in Macrophages by Antisense Oligonucleotides, Ribozymes and Acyclic Nucleoside Phosphonate Analogues Delivered in pH‐Sensitive Liposomes (2001) (0)
inHerpes Simplex Virus- andMock-Infected Cells (1984) (0)
Differential anti-HBV activity in vitro of three potent inhibitors of inosine monophosphate dehydrogenase: Mycophenolic acid 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and ribavirin (1998) (0)
Neuron-specific targeting of lentiviral vectors using neuron-restrictive silencer elements (2002) (0)
1-substituted 4-methoxy-2-phenylbenzimidazoles as NNRTIs: Synthesis and anti-HIV evaluation (2003) (0)
Fluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity (1995) (0)
Pyrimidine arabinofuranosyl nucleosides with 5-substituted long, branched and unsaturated chains: synthesis and antiherpes properties. (1981) (0)
Potent and Selective Anti‐HIV Activity of 5‐Chloro‐Substituted Derivatives of 3′‐Azido‐2′,3′‐Dideoxycytidine, 3′‐Fluoro‐2′,3′‐Dideoxycytidine, and 2′,3′‐Didehydro‐2′,3′‐Dideoxycytidine (1990) (0)
PREPARATION, SPECTRAL PROPERTIES AND BIOLOGICAL ACTIVITIES OF 5-BROMO-6-METHYL-2′-DEOXYURIDINE AND 5-IODO-6-METHYL-2′-DEOXYURIDINE (1980) (0)
Thermal activation of the antiviral activity of synthetic polyribonucleotides: influence of DEAE-dextran in various cell cultures. (1971) (0)
The synthesis and biological properties of some 5-substituted-2'-deoxyuridines. (1985) (0)
Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides. (1996) (0)
The Chemistry of 2′,3′‐Seconucleosides. Part 2. Reactions and Biological Properties of 2′,3′‐Secopyrimidine Ribonucleosides. (1986) (0)
Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides. (2004) (0)
Synthesis and Biological Evaluation of Isonucleosides Derived from Methyl 3,5‐Anhydro‐2‐O‐(2‐fluorobenzyl)‐D‐xylofuranosides. (2002) (0)
Synthesis, Structure, and Antitumor and Antiviral Activities of a Series of 5-Halouridine Cyclic 3′,5′-Monophosphates. (1986) (0)
Negatively charged albumins exhibit a potent invitro anti-HIV-1 activity and a unique inhibitory action on syncytium formation (1991) (0)
Synthesis, Antiretrovirus Effects, and Phosphorylation Kinetics of 3′-Isocyano-3′-deoxythymidine and 3′-Isocyano-2′,3′-dideoxyuridine. (1990) (0)
Thiazolylthioacetamides as a Novel Class of Potential Antiviral Agents (2011) (0)
In vitro selection of high level resistance towards foscarnet and acyclic nucleoside phosphonates using a patient isolate displaying the multinucleoside resistant pattern (1999) (0)
CADA compounds: potent CD4-targeted HIV inhibitors (2004) (0)
The Novel Fluorinated C-6 Substituted Uracil Derivatives: Synthesis, Biological Evaluations, 1H And 13C NMR Conformational And X-Ray Crystal Structure Studies (2007) (0)
Prospects of anti-HIV therapy and prophylaxis (2011) (0)
Modulation of metabolism by flavouring esters as a strategy to enhance transepithelial transport of esterase sensitive prodrugs (1998) (0)
Effect of palmitoylcarnitine on transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers (1997) (0)
Strategies for the treatment of dengue virus infections: a narrative account. (2010) (0)
PRODRUGS OF 5-ETHYL-2′-DEOXYURIDINE, I. SYNTHESES AND ANTIVIRAL ACTIVITIES OF SOME 5′-O-ACYL DERIVATIVES (1985) (0)
Analysis oftheHerpesSimplex VirusGenomeDuring InVitro Latency inHumanDiploid Fibroblasts andRatSensory Neurons (1984) (0)
IS INDEPENDENT OF ERROR-PRONE REPLICATION (2006) (0)
Curved bridge Mechelse Steenweg, Kortenberg, Belgium : Recent structure in Belgium and the Netherlands (2003) (0)
The Novel Spacered Cyclopropyl Nucleoside Analogues : Synthesis, Structural Studies And Biological Evaluation Of The Purine Supstituted 1-Aminocyclopropane-1-Carboxylic Acids And 1-Amino-1-Hydroxymethylcyclopropanes (2002) (0)
Synthesis and anti-HIV Activity Evaluation of Novel 2,4-Disubstituted 7-Methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo[4,5-e][1,2]thiadiazines. (2008) (0)
HPMPC treatment of a patient with esophageal and hypopharyngeal papillomatosis (1994) (0)
Inhibition of autoimmune joint inflammation in mice by an antagonist of the SDF-1 chemokine receptor CXCR4 (2002) (0)
Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti‐HIV‐1 Agents (2015) (0)
A Crusade for Drugs to Conquer Viruses (2000) (0)
Activity of D- and L-enantiomers of cyclohexenyl guanine against herpesviruses (2000) (0)
Novel Bicyclic Furanopyrimidines with Dual anti‐VZV and ‐HCMV Activity. (2004) (0)
CXCL12/ALEXA FLUOR 647 : a novel, non-radioactive probe for flow cytometric evaluation of CXCR4 inhibitors (2004) (0)
2‐Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5‐ Anhydrohexitol Nucleoside Derivatives. (1995) (0)
Kinetics of the 3’ processing reaction of HIV-1 integrase as investigated with Fluorescence Cross Correlation Spectroscopy (2004) (0)
the L-enantiomer of the highly specific HIV-1 reverse transcriptase inhibitor TSAO-T (1995) (0)
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC): A new approach for the treatment of human papillomavirus (HPV-induced tumors (1995) (0)
Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles (2023) (0)
Ajoene [(e,z)-4,5,9-trithiadodeca-1,6,11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations. (1998) (0)
HIV-1 specific inhibition of reverse transcriptase by TIBO-derivatives: a new mechanism of antiviral action discovered by drug screening (1990) (0)
E-5- (2-halogenovinyl) -2'-desoxycytydines; their process for the preparation and their use in pharmaceutical compositions for the treatment of virus diseases (1980) (0)
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-N-substituted-hydrazinecarbothioamides (2012) (0)
The determination of bis(pivaloyloxymethyl)-PMEA and its degradation products mono(POM)-PMEA and PMEA using perfusion chromatography (1996) (0)
Interferon: the quintessence of a quinquagenarian. (2009) (0)
Synthesis and biological activity of meso-tetrakis (2,10-dioxo-2H, 10H-pyrano [2,3-f] chromene-9-yl) porphyrins (2007) (0)
Intestinal metabolism and permeability of bis-pivaloyloxymethyl-PMEA in an in vitro cell culture system of the intestinal mucosa (1995) (0)
Introductory Article: Anti-infectives: Present status of HIV protease inhibitors in the control of HIV infections (1996) (0)
Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region (2022) (0)
Inhibition of the formation of HIV-1 DNA by TIBO compounds (1991) (0)
Synthesis of novel biologically active methylene derivatives of sydnones (2013) (0)
Antiviral Activity of (S)-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine [(S)-HPMPA] (1987) (0)
Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues. (1998) (0)
Synthesis and Conformational Study of 3-Hydroxy-4-(hydroxymethyl)-1- cyclohexanyl Purines and Pyrimidines. (1997) (0)
Mechanism of inhibitory effect of dextran sulfate (0)
A novel inhibitor of the CRM1-mediated Rev export (2001) (0)
Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents (2013) (0)
Exploring a new approach in AIDS therapy. Design, synthesis and biological evaluation of potential dimerization inhibitors of HIV-1 reverse transcriptase (2005) (0)
Synthesis of 2′-Azido-2′,3′-didehydro-2′,3′-dideoxythymidine. (1993) (0)
Anti-varicella-zoster virus bicyclic nucleosides: Synthesis and in vitro evaluation of 2 ',3 '-dideoxy nucleoside derivatives (2002) (0)
Synthesis and Antiviral Activity of Some New 1H-1,2,4-Triazole Derivatives. (1995) (0)
Structure-Based Design of [(2-Hydroxyethoxy)Methyl]-6-(Phenylthio)-Thymine Derivatives as Nonnucleoside Hiv-1 Reverse Transcriptase Inhibitors: From HEPTs to Sulfinyl-Substituted HEPTs (2022) (0)
Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf (2012) (0)
Mannose-specific lectins as novel microbicides against HIV (2003) (0)
Nonpolynucleotide Interferon Inducers (2018) (0)
Alkoxy-5-nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds. (2010) (0)
Enhanced antiviral activity of hexadecyloxypropyl-PME-N-6-cyclopropyl-diaminopurine against herpesviruses, hepatitis B virus and vaccinia virus, in vitro (2007) (0)
The thiocarboxanilide UC-781 is a potential virucidal drug (1998) (0)
Construction of chimeric feline immunodeficiency virus reverse transcriptase to map its lack of susceptibility to non-nucleoside reverse transcriptase inhibitors (2003) (0)
Inhibition of Simian immunodeficiency virus (SIV) from African green monkeys by TIBO and HEPT derivatives (1992) (0)
Resistance profile of human immunodeficiency virus to mannose-binding proteins (2004) (0)
The Twentieth International Conference on Antiviral Research (2007) (0)
Design, synthesis, and biological evaluation of novel anti-VZV agents (2007) (0)
Rapid emergence of HIV-1 resistance to R82913 in only a minority of treated patients (1993) (0)
Synthesis, Antiviral and Cytotoxicactivities of 2-Phenyl, 3-Substituted Quinazolin-4(3H)-Ones (2010) (0)
A Convenient Synthesis of New Purinyl-homo-carbonucleosides on a Cyclopentane Ring Fused with Pyridazine. (2005) (0)
Application of high strength prestressing strands in precast beams made with self-compacting concrete (2005) (0)
Novel mutations in HIV-1 integrase associated with resistance to diketo acids (2001) (0)
ChemInform Abstract: Synthesis and Biological Activities of (Z) and (E) α-Ethenyl Acyclonucleosides. (2002) (0)
Synthesis and Antiviral Activities of Novel Purinyl- and Pyrimidinylcarbanucleosides Derived from Indan (2008) (0)
Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation. (2022) (0)
Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities (2020) (0)
Specific CD4 down-modulating compounds with potent anti-HIV and HHV-7 activity (2002) (0)
New clues in the acetaminophen mystery (2005) (0)
Synthesis and Biological Evaluationof 6-Substituted Purinylcarbanucleosides with a Cyclopenta[b]thiophene Pseudosugar (2009) (0)
Synthesis and in vitro Evaluation of Novel anti‐Varicella‐Zoster Virus (VZV) Nucleosides (2001) (0)
Therapeutic potential of acyclic nucleoside phosphonates in the treatment of herpes- and retrovirus infections (i.e. HPMPC against MCMV infection in SCID mice) (1992) (0)
Kinetics of HIV integration as analyzed by quantitative PCR (2001) (0)
New developments in anti-HIV chemotherapy. (2001) (0)
Synthesis and anti-HIV Activity of New Modified 1,2,3-Triazole Acyclonucleosides. (2002) (0)
New 1,1,3-trioxo-2H,4H-thieno[3,4-e]thiadiazine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase (1997) (0)
Synthesis of novel CADA compounds and their anti-HIV and CD4 down-modulation activities (2004) (0)
New chemical compounds, processes for their preparation and their use as medicine with antiviral effective (1979) (0)
Quantification of lentiviral vectors by a two-step real-time RT-PCR (2002) (0)
Trisubstituted benzimidazoles as NNRTIs: synthesis and anti-HIV evaluation (2002) (0)
Triple or quadruple drug therapy in naive HIV-1 seropositives does not prevent the selection of resistant virus in a subset of patients (1998) (0)
Novel nucleoside phosphoramidates: studies on the stereochemical requirements of the phosphoramidate amino acid (1996) (0)

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