Erika L. Pearce
#48,854
Most Influential Person Now
American immunologist
Erika L. Pearce's AcademicInfluence.com Rankings
Erika L. Pearcebiology Degrees
Biology
#3131
World Rank
#4831
Historical Rank
#1310
USA Rank
Immunology
#411
World Rank
#426
Historical Rank
#84
USA Rank
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Biology
Erika L. Pearce's Degrees
- PhD Immunology Stanford University
Why Is Erika L. Pearce Influential?
(Suggest an Edit or Addition)According to Wikipedia, Erika L. Pearce is an American immunologist. She is the Bloomberg Distinguished Professor at the Johns Hopkins University after serving as director and a scientific member at Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. Her work investigates the connection between metabolism and immune cell function with a particular focus on the regulation of T-cells. In 2018, she was awarded the Leibniz Prize for her "outstanding work in metabolism and inflammation research."
Erika L. Pearce's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression (2015) (1907)
- Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens (2014) (1612)
- Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis (2013) (1582)
- Enhancing CD8 T-cell memory by modulating fatty acid metabolism (2009) (1325)
- Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. (2012) (1177)
- Metabolic pathways in immune cell activation and quiescence. (2013) (1151)
- Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin (2003) (1037)
- Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) (1005)
- Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming (2016) (883)
- T cell metabolism drives immunity (2015) (838)
- TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation (2014) (778)
- Metabolic Instruction of Immunity (2017) (735)
- Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation (2014) (571)
- Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. (2014) (542)
- The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. (2015) (457)
- Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. (2012) (453)
- Unraveling the Complex Interplay Between T Cell Metabolism and Function. (2018) (428)
- CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability (2013) (425)
- Metabolic switching and fuel choice during T‐cell differentiation and memory development (2012) (405)
- Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. (2016) (382)
- The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites (2016) (379)
- Autophagy is essential for effector CD8 T cell survival and memory formation (2014) (321)
- Emerging concepts of T cell metabolism as a target of immunotherapy (2016) (267)
- Metabolism in T cell activation and differentiation. (2010) (252)
- Generation of CD8 T Cell Memory Is Regulated by IL-121 (2007) (247)
- Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function. (2016) (209)
- Arginase 1 is an innate lymphoid cell-intrinsic metabolic checkpoint controlling type 2 inflammation (2016) (203)
- Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function. (2018) (202)
- Targeting T cell metabolism for therapy. (2015) (201)
- Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells (2018) (187)
- Mitochondrial Priming by CD28 (2017) (185)
- Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells. (2016) (172)
- Metabolic interventions in the immune response to cancer (2019) (169)
- Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation (2019) (167)
- Enhancing CD 8 T Cell Memory by Modulating Fatty Acid Metabolism (2010) (164)
- Acetate Promotes T Cell Effector Function during Glucose Restriction. (2019) (156)
- Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function (2019) (154)
- Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice (2012) (149)
- Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms (2018) (147)
- Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development. (2018) (142)
- Amino Assets: How Amino Acids Support Immunity. (2020) (142)
- Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity (2019) (131)
- Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage (2019) (129)
- Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer (2016) (125)
- Metabolic modeling of single Th17 cells reveals regulators of autoimmunity (2021) (110)
- Triacylglycerol synthesis enhances macrophage inflammatory function (2020) (97)
- Mechanistic Target of Rapamycin Inhibition Extends Cellular Lifespan in Dendritic Cells by Preserving Mitochondrial Function (2014) (96)
- The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites (2016) (80)
- Ancillary Activity: Beyond Core Metabolism in Immune Cells. (2017) (78)
- Polyamine metabolism is a central determinant of helper T cell lineage fidelity (2021) (71)
- Immunometabolism in 2017: Driving immunity: all roads lead to metabolism (2017) (65)
- Making sense of inflammation, epigenetics, and memory CD8+ T‐cell differentiation in the context of infection (2006) (64)
- c-Myc-induced transcription factor AP4 is required for CD8+ T cell-mediated host protection (2014) (63)
- Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2 (2018) (61)
- Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy (2020) (58)
- TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. (2010) (54)
- Th1 and Th2 Cells Help CD8 T-Cell Responses (2007) (53)
- Cutting Edge: Requirement for TRAF6 in the Induction of T Cell Anergy1 (2008) (52)
- Functional Characterization of MHC Class II-Restricted CD8+CD4− and CD8−CD4− T Cell Responses to Infection in CD4−/− Mice1 (2004) (47)
- Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans (2020) (46)
- Fatty Acid Oxidation Is Essential for Egg Production by the Parasitic Flatworm Schistosoma mansoni (2012) (43)
- IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals (2020) (39)
- Global Epidemiology of Dengue Hemorrhagic Fever: An Update (2017) (27)
- Targeting memory T cell metabolism to improve immunity (2022) (26)
- Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity (2020) (26)
- The importance of methionine metabolism (2019) (23)
- A common framework of monocyte-derived macrophage activation (2022) (22)
- Expanding the role of metabolism in T cells (2015) (21)
- Fever supports CD8+ effector T cell responses by promoting mitochondrial translation (2021) (21)
- Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming. (2017) (19)
- Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity. (2021) (19)
- Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect (2020) (18)
- Potassium shapes antitumor immunity (2019) (18)
- Sulfur sequestration promotes multicellularity during nutrient limitation (2021) (16)
- IL-18 Synergizes with IL-7 To Drive Slow Proliferation of Naive CD8 T Cells by Costimulating Self-Peptide–Mediated TCR Signals (2014) (16)
- A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways (2018) (13)
- Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism (2021) (13)
- Erratum: Memory CD8 + T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development (Immunity (2014) 41(1) (75–88), (S1074761314002246) (10.1016/j.immuni.2014.06.005)) (2018) (12)
- Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. (2021) (12)
- EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism (2020) (11)
- Intracellular infection and immune system cues rewire adipocytes to acquire immune function. (2022) (11)
- Metabolic Dynamics of In Vitro CD8+ T Cell Activation (2020) (10)
- Host dysbiosis negatively impacts IL-9-producing T-cell differentiation and antitumour immunity (2020) (10)
- Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells (2020) (10)
- Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade (2021) (10)
- Fatty acid synthesis tips the TH17-Treg cell balance (2014) (10)
- Helper T cell differentiation and the problem of cellular inheritance (2003) (9)
- Metabolism as a driver of immunity (2021) (8)
- Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment. (2022) (8)
- mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity (2022) (8)
- TRAF6 inhibits Th17 differentiation and TGF- (cid:1) –mediated suppression of IL-2 (2010) (7)
- Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells (2018) (7)
- Metabolic and Epigenomic Regulation of Th17/Treg Balance by the Polyamine Pathway (2020) (6)
- MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells (2020) (6)
- A Sweet Deal for Diabetes (2018) (6)
- Regulated by IL-12 Generation of CD8 T Cell Memory Is (2007) (5)
- Targeting MDM2 enhances anti-leukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. (2022) (5)
- An LKB1–mitochondria axis controls TH17 effector function (2022) (5)
- Polyamine metabolism regulates the T cell epigenome through hypusination (2020) (4)
- Th 1 and Th 2 Cells Help CD 8 T-Cell Responses (2007) (4)
- Resident TH2 cells orchestrate adipose tissue remodeling at a site adjacent to infection (2022) (4)
- MYC sensitises cells to apoptosis by driving energetic demand (2022) (3)
- Cell Responses to Infection in CD 4 T − CD 4 − and CD 8 − CD 4 + II-Restricted CD 8 Functional Characterization of MHC Class (2004) (3)
- Tofacitinib suppresses IL-10/IL-10R signaling and modulates host defense responses in human macrophages. (2021) (3)
- When Hexokinase Gets that NAG-ing Feeling…. (2016) (3)
- Glucose makes Treg lose their temper. (2021) (3)
- Appetite for Arginine: Metabolic Control of Macrophage Hunger. (2020) (2)
- Predictive framework of macrophage activation (2021) (2)
- Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development (2023) (2)
- mTOR-associated Mitochondrial Energy Metabolism Limits Mycobacterium ESX-1-induced Cytotoxicity (2022) (1)
- Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function (2023) (1)
- Metabolic competition in the tumor microenvironment determines cancer progression (TUM7P.1016) (2015) (1)
- TRAF6 is an Intrinsic Negative Regulator of Th17 Differentiation (47.32) (2009) (1)
- Cytokines establish T cell memory by regulating mitochondrial metabolism (46.7) (2011) (1)
- In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation (2022) (1)
- Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. (2023) (0)
- Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis (2019) (0)
- Inhibition of mTOR promotes dendritic cell activation and survival and enhances therapeutic autologous vaccination in mice (52.4) (2012) (0)
- HLX regulates hematopoiesis by modulating cell metabolism (2017) (0)
- How to make a better T cell: in vivo CRISPR screens have some answers (2021) (0)
- Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection (2022) (0)
- HIGHLY PHAGOCYTIC LIPID-ASSOCIATED MACROPHAGES (LAMs) ARE INCREASED IN COLONIC LAMINA PROPRIA IN OBESITY (2022) (0)
- How Does Metabolism Influence the Function of Different T Cell Types (2017) (0)
- Metabolic interventions in the immune response to cancer (2019) (0)
- Plasmacytoid dendritic cell activation is dependent upon type I IFN-driven fatty acid oxidation (IRM9P.456) (2015) (0)
- Science Magazine (2011) (0)
- 266 Decoding the role of polyamine metabolism on anti-tumor immunity in head and neck cancer (2023) (0)
- Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage (2019) (0)
- Mechanistic Target of Rapamycin Inhibition (2014) (0)
- Mummichog, pathway and network analysis for Metabolomics (2015) (0)
- Plasma cell mitochondrial pyruvate import controls the duration of humoral immunity. (2016) (0)
- eUREkA! T cells answer nature's call. (2023) (0)
- Development of CD8 T cell responses (2005) (0)
- Autologous Vaccination in Mice Activation and Enhances Therapeutic Rapamycin Promotes Dendritic Cell Inhibition of Mechanistic Target of (2012) (0)
- Metabolic Reprogramming Overcomes T Cell Inhibition By AML Cells (2018) (0)
- Self-reactivity controls the basal metabolism and in vivo function of CD4 T cells (2018) (0)
- Webinar | Key signaling pathways in cancer: Emerging trends in immunometabolism (2016) (0)
- 3121 – IDENTIFICATION OF METABOLIC-EPIGENETIC HUBS REGULATING HEMATOPOIETIC STEM CELL FUNCTION (2021) (0)
- AI-12 Metabolic competition in the microenvironment is a driver of cancer progression: a lesson for lupus (2018) (0)
- A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways (2018) (0)
- Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment (2023) (0)
- Role of TRAF6 as a Regulator of Endothelial Cell Activation and Angiogenesis (88.20) (2009) (0)
- A Metabolic Interplay Coordinated By Hlx Balances Hematopoietic Stem Cell Maintenance and Differentiation (2017) (0)
- Women in Metabolism: Part 3. (2015) (0)
- Research Techniques Made Simple: Profiling Cellular Energy Metabolism. (2021) (0)
- inflammatory dendritic cells Commitment to glycolysis sustains survival of NO-producing (2012) (0)
- Abstract 3679: DNAJB1-PRKACA fusion in fibrolamellar hepatocellular carcinoma induces glutamine addiction and an immunosuppressive tumor microenvironment (2023) (0)
- by Preserving Mitochondrial Function Extends Cellular Lifespan in Dendritic Cells Mechanistic Target of Rapamycin Inhibition (2014) (0)
- Tonic TCR Signaling Inversely Regulates the Basal (2020) (0)
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