Eriko Takano
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Computer Science
Eriko Takano's Degrees
- PhD Computer Science University of Tokyo
- Masters Computer Science University of Tokyo
- Bachelors Computer Science University of Tokyo
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Why Is Eriko Takano Influential?
(Suggest an Edit or Addition)According to Wikipedia, Eriko Takano is a professor of synthetic biology and a director of the Synthetic Biology Research Centre for Fine and Speciality Chemicals at the University of Manchester. She develops antibiotics and other high-value chemicals using microbial synthetic biology tools.
Eriko Takano's Published Works
Published Works
- antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters (2015) (1653)
- antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences (2011) (1435)
- antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification (2017) (991)
- antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers (2013) (777)
- Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters (2014) (677)
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Gamma-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. (2006) (322)
- Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast (2013) (277)
- Transcriptional regulation of the redD transcriptional activator gene accounts for growth‐phase‐dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2) (1992) (232)
- Computational tools for the synthetic design of biochemical pathways (2012) (224)
- Stationary‐phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated (1993) (216)
- A complex role for the γ‐butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2) (2001) (206)
- The stringent response in Streptomyces coelicolor A3(2) (1991) (200)
- Towards the sustainable discovery and development of new antibiotics (2021) (198)
- The dynamic architecture of the metabolic switch in Streptomyces coelicolor (2010) (186)
- The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways (2010) (182)
- Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms (2011) (164)
- A bacterial hormone (the SCB1) directly controls the expression of a pathway‐specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor (2005) (154)
- A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis (2014) (148)
- Construction of thiostrepton-inducible, high-copy-number expression vectors for use in Streptomyces spp. (1995) (145)
- Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production inStreptomyces coelicolor A3(2)* (2000) (140)
- Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). (2010) (137)
- An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals (2018) (127)
- Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products (2014) (89)
- Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) (1996) (88)
- Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor (2010) (87)
- Towards synthesis of monoterpenes and derivatives using synthetic biology. (2016) (76)
- Metabolomic Characterization of the Salt Stress Response in Streptomyces coelicolor (2010) (76)
- Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets (2011) (73)
- A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2) (2007) (72)
- Streptomyces hygroscopicus has two glutamine synthetase genes (1990) (67)
- Metabolomics methods for the synthetic biology of secondary metabolism (2012) (67)
- Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli. (2019) (66)
- A transatlantic perspective on 20 emerging issues in biological engineering (2017) (63)
- Metabolomics for Secondary Metabolite Research (2013) (63)
- Steps towards the synthetic biology of polyketide biosynthesis (2014) (63)
- Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli. (2015) (59)
- Synthetic biology in Streptomyces bacteria. (2011) (59)
- Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system. (2009) (58)
- Selenzyme: enzyme selection tool for pathway design (2017) (57)
- A Bistable Gene Switch for Antibiotic Biosynthesis: The Butyrolactone Regulon in Streptomyces coelicolor (2008) (55)
- Synthetic biology advances for pharmaceutical production (2015) (55)
- ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones. (2007) (52)
- Bioinformatics for the synthetic biology of natural products: integrating across the Design–Build–Test cycle (2016) (48)
- Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2) (2009) (44)
- The Border Sequence of the Balhimycin Biosynthesis Gene Cluster from Amycolatopsis balhimycina Contains bbr, Encoding a StrR-Like Pathway-Specific Regulator (2007) (44)
- Genome-wide inference of regulatory networks in Streptomyces coelicolor (2010) (43)
- redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing sigma hrdD (1996) (41)
- Genome‐wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus (2011) (40)
- Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase (2017) (40)
- Replacement of Streptomyces hygroscopicus genomic segments with in vitro altered DNA sequences. (1988) (39)
- A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production (2000) (39)
- The future of industrial antibiotic production: from random mutagenesis to synthetic biology. (2011) (37)
- Butyrolactone signalling circuits for synthetic biology. (2015) (37)
- The bialaphos resistance gene (bar) plays a role in both self-defense and bialaphos biosynthesis in Streptomyces hygroscopicus. (1988) (36)
- A ‘Plug and Play’ Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli (2016) (36)
- Type II thioesterase from Streptomyces coelicolor A3(2). (2002) (35)
- MultiMetEval: Comparative and Multi-Objective Analysis of Genome-Scale Metabolic Models (2012) (34)
- A complex role for the g-butyrolactone SCB 1 in regulating antibiotic production in Streptomyces coelicolor A 3 ( 2 ) (33)
- Bacterial Microcompartments: Biomaterials for Synthetic Biology-Based Compartmentalization Strategies. (2015) (32)
- Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice. (2013) (31)
- The bialaphos biosynthetic genes of Streptomyces hygroscopicus: cloning and analysis of the genes involved in the alanylation step. (1988) (31)
- Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2) (2011) (30)
- Comparative genome‐scale metabolic modeling of actinomycetes: The topology of essential core metabolism (2011) (30)
- Synthetic Biology of Natural Products. (2016) (30)
- Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers (2020) (29)
- SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli. (2019) (29)
- Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces (2020) (27)
- Convergent Transcription in the Butyrolactone Regulon in Streptomyces coelicolor Confers a Bistable Genetic Switch for Antibiotic Biosynthesis (2011) (26)
- Deletion of scbA enhances antibiotic production in Streptomyces lividans (2003) (26)
- Identification of genes involved in siderophore transport in Streptomyces coelicolor A3(2). (2006) (24)
- Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli (2019) (23)
- A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes (2018) (23)
- Host Systems for the Production of Recombinant Spider Silk. (2020) (22)
- Metabolomic analysis of a synthetic metabolic switch in Streptomyces coelicolor A3(2) (2011) (22)
- COMPLEX ENZYMES IN MICROBIAL NATURAL PRODUCT BIOSYNTHESIS, PART A: OVERVIEW ARTICLES AND PEPTIDES (2009) (22)
- Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol (2020) (21)
- Modeling challenges in the synthetic biology of secondary metabolism. (2013) (21)
- The bialaphos biosynthetic genes of Streptomyces viridochromogenes: cloning, heterospecific expression, and comparison with the genes of Streptomyces hygroscopicus. (1991) (21)
- Metabolomics tools for the synthetic biology of natural products. (2018) (20)
- Exploring novel bacterial terpene synthases (2020) (20)
- Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries (2019) (20)
- Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters (2019) (19)
- Exploring the metabolic state of microorganisms using metabolomics. (2011) (19)
- Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace. (2019) (19)
- The tuf3 gene of Streptomyces coelicolor A3(2) encodes an inessential elongation factor Tu that is apparently subject to positive stringent control. (1995) (18)
- The future of industrial antibiotic production: From random mutagenesis to synthetic biology (2011) (18)
- Orthogonal Regulatory Circuits for Escherichia coli Based on the γ-Butyrolactone System of Streptomyces coelicolor. (2018) (18)
- Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism (2018) (17)
- Judging synthetic biology risks (2015) (17)
- Engineering the “Missing Link” in Biosynthetic (−)-Menthol Production: Bacterial Isopulegone Isomerase (2018) (17)
- Ribosylhopane, a Novel Bacterial Hopanoid, as Precursor of C35 Bacteriohopanepolyols in Streptomyces coelicolor A3(2) (2014) (17)
- The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers (2020) (16)
- In silico design and automated learning to boost next-generation smart biomanufacturing (2020) (15)
- An automated pipeline for the screening of diverse monoterpene synthase libraries (2019) (14)
- The evolving art of creating genetic diversity: From directed evolution to synthetic biology (2021) (14)
- Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker’s Yeast (2020) (13)
- Integrated Probabilistic Annotation (IPA): A Bayesian-based annotation method for metabolomic profiles integrating biochemical connections, isotope patterns and adduct relationships. (2019) (13)
- Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases (2019) (13)
- A bacterial hormone ( the SCB 1 ) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces (2004) (12)
- Bioengineering horizon scan 2020 (2020) (11)
- Chapter 6. Regulation of antibiotic production by bacterial hormones. (2009) (11)
- Non-covalent protein-based adhesives for transparent substrates—bovine serum albumin vs. recombinant spider silk (2020) (10)
- Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction. (2018) (10)
- Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase (2018) (10)
- ppGpp and antibiotic production in Streptomyces coelicolor A3(2). (1993) (9)
- Switchable foldamer ion channels with antibacterial activity (2020) (9)
- SYNBIOCHEM–a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (2016) (9)
- Application of protein N-terminal amidase in enzymatic synthesis of dipeptides containing acidic amino acids specifically at the N-terminus. (2013) (8)
- Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. (2015) (8)
- Structure and Function of an Elongation Factor P Subfamily in Actinobacteria. (2020) (8)
- Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor (2020) (7)
- Blood, sweat, and tears: extraterrestrial regolith biocomposites with in vivo binders (2021) (7)
- Characterisation of a natural variant of the γ-butyrolactone signalling receptor (2012) (6)
- Cloning , characterization and disruption of a ( p ) ppGpp synthetase gene ( reIA ) of Streptomyces coelicolor A 3 ( 2 ) (2007) (6)
- Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling (2020) (6)
- Towards engineering and production of artificial spider silk using tools of synthetic biology (2020) (6)
- Purification and Properties of a Prokaryote Type Glutamine Synthetase from the Bialaphos Producer Streptomyces hygroscopicus SF1293 (1990) (5)
- Purification and Structural Determination of SCB1, a g -Butyrolactone That Elicits Antibiotic Production in Streptomyces coelicolor A3(2)* (2000) (5)
- University of Groningen Regulation of Antibiotic Production by Bacterial Hormones (2009) (5)
- Design and fabrication of recombinant reflectin-based multilayer reflectors: bio-design engineering and photoisomerism induced wavelength modulation (2021) (5)
- A turning point for natural product discovery – ESF‐EMBO research conference: synthetic biology of antibiotic production (2012) (5)
- Activity analysis of electrocatalytic water oxidation by trinuclear ruthenium complex on an Au particle matrix (1999) (5)
- Ribosylhopane (I), a Novel Bacterial Hopanoid, as Precursor of C35 Bacteriohopanepolyols in Streptomyces coelicolor A3(2). (2015) (4)
- Investigation of the effects of actinorhodin biosynthetic gene cluster expression and a rpoB point mutation on the metabolome of Streptomyces coelicolor M1146. (2021) (4)
- A plasmid toolset for CRISPR‐mediated genome editing and CRISPRi gene regulation in Escherichia coli (2021) (4)
- Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets. (2021) (2)
- Synthetic biology approaches to actinomycete strain improvement (2021) (2)
- Design and fabrication of recombinant reflectin-based Bragg reflectors: bio-design engineering and photoisomerism induced wavelength modulation (2020) (2)
- The “Three Cs” of Novel Antibiotic Discovery and Production through Synthetic Biology: Biosynthetic Gene Clusters, Heterologous Chassis, and Synthetic Microbial Consortia (2018) (2)
- Detection and Quantification of Butyrolactones from Streptomyces. (2018) (2)
- PROMOTION OF ACCLIMATIZATION OF PLANT SEEDLINGS BY ULTRA-VIOLET RAYS IRRADIATION (1988) (2)
- Synthetic Biology UK (2018) (2)
- Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor (2011) (2)
- How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity (2022) (2)
- Harnessing intercellular signals to engineer the soil microbiome. (2021) (2)
- The Growth Optimal Asset Pricing Model under Regime Switching: With an Application to J-REITs ∗ (2004) (2)
- University of Groningen Identification of genes involved in siderophore transport in Streptomyces coelicolor A 3 ( 2 (2017) (1)
- Biotechnological application of Streptomyces for the production of clinical drugs and other bioactive molecules. (2022) (1)
- SYNBIOCHEM Design-Build-Test-Learn pipeline (2018) (1)
- Synthetic Biology of Antibiotic Production (2014) (1)
- Output ordering and prioritisation system (OOPS): ranking biosynthetic gene clusters to enhance bioactive metabolite discovery (2018) (1)
- Characterisation of a natural variant of the γ-butyrolactone signalling receptor (2012) (1)
- University of Groningen The stringent response in Streptomyces coelicolor A 3 ( 2 ) (2017) (1)
- Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A (2021) (1)
- Chapter 23: Synthetic biology of antibiotic production (2015) (0)
- Plasmids used in this study. (2020) (0)
- List of terpene synthases annotated in phylogenetic tree, Fig 1. (2020) (0)
- Chapter 19: Synthetic biology of natural products (2014) (0)
- Author response: Bioengineering horizon scan 2020 (2020) (0)
- antiSMASH: ChapterKey 309523 (2012) (0)
- The role of ScbR in a bacterial hormone system of Streptomyces coelicolor (2018) (0)
- Bacterial terpene synthases neighbour-joining tree. (2020) (0)
- University of Groningen Type II thioesterase from Streptomyces coelicolor A 3 ( 2 ) (2018) (0)
- Separating the wheat from the chaff: a prioritisation pipeline for the analysis of metabolomics datasets (2011) (0)
- University of Groningen A turning point for natural product discovery-ESF-EMBO research conference (2017) (0)
- CRYPTON - A genome-based generalized strategy to activate crypticantibiotic biosynthesis gene clusters in Actinomycetales (2009) (0)
- BIOT 122-Transcriptome dynamics-based gene network analysis for secondary metabolism (2006) (0)
- 1 Metabolomics tools for the synthetic biology of natural products 1 2 3 (2018) (0)
- Genome Mining for antibiotics biosynthesis pathways with antiSMASH 3 (2014) (0)
- Characterisation of anatural variant of the gamma-butyrolactonesignalling receptor (2012) (0)
- A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes (2018) (0)
- University of Groningen A cryptic type I polyketide synthase ( cpk ) gene cluster in Streptomyces coelicolor A 3 ( 2 ) (2017) (0)
- University of Groningen Noncoding RNA of Glutamine Synthetase I Modulates Antibiotic Production in Streptomyces coelicolor A3(2) D'Alia, (2009) (0)
- University of Groningen A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production Aigle, (2000) (0)
- University of Groningen Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production in Streptomyces coelicolor A3(2) Takano, (2000) (0)
- Towards the sustainable discovery and development of new antibiotics. (2021) (0)
- Automatic translation of high ‐ level bio ‐ designs into wet ‐ lab protocols through learning and formalizing expert ’ s practices (2015) (0)
- TOWARDS BIOTECHNOLOGY 2.0: SYNTHETIC BIOLOGY OF BIOACTIVE MOLECULES (2012) (0)
- Qualitative model for the evolution of NRPS/PKS domains. (2014) (0)
- The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers (2020) (0)
- Natural Product Biosynthesis in Escherichia coli: Mentha Monoterpenoids. (2016) (0)
- University of Groningen Cloning , characterization and disruption of a ( p ) ppGpp synthetase gene ( relA ) of Streptomyces coelicolor A 3 ( 2 ) (2017) (0)
- Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism (2018) (0)
- Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters (2019) (0)
- Cloning, characterization and disruption of a (p)ppGpp synthetase gene (reIA) of Streptomyces coelicolor A3(2) (2007) (0)
- Synthetic Biology: Reports from CSHA 2016 and More (2018) (0)
- SYNBIOCHEM - Combinatorial plasmid libraries for material monomer production in Escherichia coli. (2019) (0)
- Editorial overview: Systems and Synthetic Biology. (2022) (0)
- An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals (2018) (0)
- Streptomyces lividans ; Streptomyces coelicolor ) (2003) (0)
- Protein sequences of selected terpene synthases. (2020) (0)
- Induction of the Stringent Response in Streptomyces Coelicolor A3(2) and Its Possible Role in Antibiotic Production (1991) (0)
- Natural products: tools and more special issue. (2013) (0)
- Natural Products: Tools and More. (2013) (0)
- Towards high-value chemicals production harnessing synthetic biology (2017) (0)
- Structure and function of a novel elongation factor P subfamily in Actinobacteria (2020) (0)
- glutamine synthetase genes. Streptomyces hygroscopicus has two (2013) (0)
- SEGMENTS WITH IN VITRO ALTERED DNA SEQUENCES (2006) (0)
- Non-coding RNA of glutamine synthetase I modulates antibiotic production in 1 Streptomyces coelicolor A 3 ( 2 ) (2009) (0)
- Enhanced Hydrogenation Activity of ZnO Catalyst Thermally Treated under UHV Atmosphere (2004) (0)
- Fatigue and Creep Life Prediction Method for Plastic Materials (2010) (0)
- Edinburgh Bioengineering horizon scan 2020 (2020) (0)
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