Erin G. Schuetz

Q: What Schools Are Affiliated With Erin G. Schuetz

Erin G. Schuetz is affiliated with the following schools: Virginia Commonwealth University, Kumamoto University, University of California, San Francisco

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Erin G. Schuetz

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Erin G. Schuetz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression (2001) (2153)
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses (1998) (1368)
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008) (1040)
Identification of functionally variant MDR1 alleles among European Americans and African Americans (2001) (1037)
Genetic contribution to variable human CYP3A-mediated metabolism. (2002) (973)
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. (1996) (524)
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. (1987) (509)
Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. (2002) (477)
Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix (1988) (470)
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4 (2003) (460)
Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression (2003) (418)
Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450* (2001) (392)
The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR (2000) (377)
Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. (2001) (340)
Identification of an inducible form of cytochrome P-450 in human liver. (1985) (329)
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. (2002) (314)
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. (1985) (305)
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. (2001) (299)
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. (2003) (281)
Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. (2002) (278)
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. (1996) (274)
Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms (2003) (273)
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. (1997) (267)
Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. (2006) (267)
Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. (1995) (262)
Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. (1995) (259)
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. (2010) (255)
Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue (2011) (249)
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. (1992) (245)
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. (2009) (242)
Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice* (2004) (231)
6′,7′‐Dihydroxybergamottin in grapefruit juice and Seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P‐glycoprotein (1999) (228)
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. (2008) (218)
PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. (2004) (207)
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. (1985) (203)
Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes (1993) (201)
THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS* (2000) (198)
Variability in human cytochrome P450 paclitaxel metabolism. (1995) (193)
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. (2002) (192)
Use of human hepatocytes to study P450 gene induction. (1996) (188)
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. (1997) (175)
Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. (1986) (174)
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. (1998) (172)
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia (2000) (168)
Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia (2006) (168)
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. (2002) (165)
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. (1994) (164)
Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. (1984) (164)
Pharmacogenetic Characteristics of Indinavir, Zidovudine, and Lamivudine Therapy in HIV-Infected Adults: A Pilot Study (2006) (163)
Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo. (1984) (160)
Expression of cytochrome P450 3A in amphibian, rat, and human kidney. (1992) (157)
CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. (2003) (149)
Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein (2002) (145)
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. (1986) (143)
Tacrolimus Dosing in Adult Lung Transplant Patients Is Related to Cytochrome P4503A5 Gene Polymorphism (2004) (140)
Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. (2008) (139)
Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. (2005) (137)
Novel Single Nucleotide Polymorphisms in the Promoter and Intron 1 of Human Pregnane X Receptor/NR1I2 and Their Association with CYP3A4 Expression (2008) (136)
Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. (1986) (130)
Expression of Constitutive Androstane Receptor Splice Variants in Human Tissues and Their Functional Consequences (2004) (122)
Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia. (2004) (122)
PharmGKB summary: very important pharmacogene information for CYP3A5. (2012) (121)
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes. (2000) (121)
Structural Determinants of P-Glycoprotein-Mediated Transport of Glucocorticoids (2003) (120)
Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression (2010) (114)
The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. (2003) (114)
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. (2000) (114)
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. (1996) (112)
Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5 (2005) (111)
Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. (1990) (110)
Interindividual Variability in Cytochrome P450–Mediated Drug Metabolism (2016) (109)
MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype (2006) (108)
The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients. (2002) (106)
The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver. (2000) (102)
Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. (1998) (102)
Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. (2005) (101)
Interplay between vitamin D and the drug metabolizing enzyme CYP3A4 (2013) (98)
Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. (1993) (94)
Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol-inducible form) in pyridine N-oxidation. (1988) (94)
CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)* (2011) (94)
Mdr1 limits CYP3A metabolism in vivo. (2000) (93)
Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors. (2003) (92)
Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel. (1988) (89)
Drug Transporters on Arachnoid Barrier Cells Contribute to the Blood–Cerebrospinal Fluid Barrier (2013) (84)
Induction of cytochromes P450. (2001) (84)
A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine (2008) (81)
A Ligand-Based Approach to Understanding Selectivity of Nuclear Hormone Receptors PXR, CAR, FXR, LXRα, and LXRβ (2002) (81)
Pharmacogenetics of Deoxycytidine Kinase: Identification and Characterization of Novel Genetic Variants (2007) (81)
G enetic contribution to variable human CYP 3 A-mediated metabolism (2002) (80)
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. (1992) (79)
Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes. (1998) (78)
Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors) (2005) (77)
Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. (2003) (76)
A Phosphomimetic Mutation at Threonine-57 Abolishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Receptor (2009) (75)
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. (2004) (72)
Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes. (1993) (71)
Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. (2013) (70)
A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. (2007) (68)
Impact of ABCB1 (MDR1) haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 *3/*3 non-expressors. (2006) (68)
Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. (1990) (66)
Association of Breast Cancer Resistance Protein/ABCG2 Phenotypes and Novel Promoter and Intron 1 Single Nucleotide Polymorphisms (2008) (66)
Hepatocellular phenotype in Vitro is influenced by biophysical features of the collagenous substratum (1991) (63)
Sp1 and Egr-1 Have Opposing Effects on the Regulation of the RatPgp2/mdr1b Gene* (1999) (63)
Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1 (2010) (63)
G2677T and C3435T Genotype and Haplotype Are Associated With Hepatic ABCB1 (MDR1) Expression (2006) (59)
Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. (2002) (52)
CYP2C9*1B Promoter Polymorphisms, in Linkage with CYP2C19*2, Affect Phenytoin Autoinduction of Clearance and Maintenance Dose (2010) (52)
The impact of pharmacogenomic factors on acute persistent rejection in adult lung transplant patients. (2005) (52)
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content (2015) (52)
Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver. (1986) (51)
Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation. (2012) (51)
Lessons from the CYP3A4 promoter. (2004) (49)
Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability. (2014) (48)
Phenotypic variability in induction of p‐glycoprotein mrna by aromatic hydrocarbons in primary human hepatocytes (1995) (47)
Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel. (1994) (44)
Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene‐7,8‐diol‐9,10‐epoxide–induced DNA damage (2002) (43)
ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY (2005) (42)
Ontogeny and Sorafenib Metabolism (2012) (42)
The Influence of CYP3A5 Expression on the Extent of Hepatic CYP3A Inhibition Is Substrate-Dependent: An in Vitro-in Vivo Evaluation (2008) (42)
The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation (2009) (42)
Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids. (1995) (42)
Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver (2017) (40)
Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes. (1993) (39)
Functional Characterization of the Promoter of Human Carbonyl Reductase 1 (CBR1). Role of XRE Elements in Mediating the Induction of CBR1 by Ligands of the Aryl Hydrocarbon Receptor (2007) (39)
Creation of Polarized Cells Coexpressing CYP3A4, NADPH Cytochrome P450 Reductase and MDR1/P-glycoprotein (2004) (38)
Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats. (1992) (36)
A Comparison of Null and Pronoun Anaphora in First Language Acquisition Studies in the Acquisition of Anaphora: Defining the Constraints , ) (1986) (36)
Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians. (2012) (36)
Etoposide pathway. (2009) (36)
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. (1993) (36)
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions (2018) (36)
Promiscuous regulator of xenobiotic removal (2001) (35)
Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450 (2006) (35)
Regulation of Coagulation Factor XI Expression by MicroRNAs in the Human Liver (2014) (34)
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix. (1990) (34)
Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver. (1994) (34)
Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans (2018) (33)
Expression of the Pregnane X Receptor in Mice Antagonizes the Cholic Acid–Mediated Changes in Plasma Lipoprotein Profile (2005) (33)
Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes. (1990) (33)
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex (2018) (33)
Hepatocyte culture in study of P450 regulation. (1991) (33)
Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen (2009) (32)
Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. (1997) (32)
The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans (2013) (32)
Drug disposition as determined by the interplay between drug‐transporting and drug‐metabolizing systems (1999) (32)
PharmGKB Update: II. CYP3A5, Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (2004) (31)
Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors (2017) (31)
The impact of pharmacogenomic factors on steroid dependency in pediatric heart transplant patients using logistic regression analysis. (2004) (30)
Critical role of extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes. (1995) (30)
The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans (2008) (29)
Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity (2019) (29)
A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. (2002) (29)
Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency (2018) (29)
Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s (2013) (28)
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis (2011) (27)
Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene. (2012) (25)
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells. (2012) (25)
The PXR crystal structure: the end of the beginning. (2002) (24)
Multisite Phosphorylation of Human Liver Cytochrome P450 3A4 Enhances Its gp78- and CHIP-mediated Ubiquitination (2011) (24)
Mdr1b facilitates p53-mediated cell death and p53 is required for Mdr1b upregulation in vivo (2001) (23)
Bromocriptine Transcriptionally Activates the Multidrug Resistance Gene (pgp2/mdr1b) by a Novel Pathway* (1997) (23)
Why Do Most Human Liver Cytosol Preparations Lack Xanthine Oxidase Activity? (2014) (23)
Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes. (1991) (22)
Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. (2015) (21)
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles (2015) (20)
Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes (2006) (20)
SUGP1 is a novel regulator of cholesterol metabolism (2016) (19)
Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver (2016) (18)
Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2 (2010) (18)
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism (2017) (18)
Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450. (1990) (18)
The CYP 3 A 4 * 1 B Variant Is Related to the Onset of Puberty , A Known Risk Factor for the Development of Breast Cancer 1 (2003) (17)
Induction of P‐Glycorprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells (1995) (16)
Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel. (1994) (16)
Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice (2018) (16)
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism (2018) (16)
Induction of cytochromes P-450b/e by phenobarbital in primary culture of adult rat hepatocytes: test of differentiated liver gene expression. (1989) (15)
Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans (2006) (14)
The impact of pharmacogenomic factors on steroid dependency in pediatric heart transplant patients using logistic regression analysis (2004) (14)
Induction of Cytochrome P-450 by Glucocorticoids in Rat Liver (2001) (13)
Sequential Analysis of Tacrolimus Dosing in Adult Lung Transplant Patients With ABCB1 Haplotypes (2005) (13)
ADME transcriptome in Hispanic versus White donor livers: Evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics (2006) (12)
Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes (2007) (12)
Cisapride: A potential model substrate to assess cytochrome P4503A4 activity in vivo (2003) (12)
Genetic effects on liver chromatin accessibility identify disease regulatory variants. (2021) (12)
Tandem machine learning for the identification of genes regulated by transcription factors (2005) (11)
Genetic contribution to variable human CYP3A-mediated metabolism (2002) (10)
JPET # 69310 1 Expression of CAR splice variants in human tissues and their functional consequences (2004) (10)
The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia (2001) (10)
A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex‐Biased Phenotypes (2020) (10)
Expression of multiple proteins structurally related to gamma‐glutamyl transpeptidase in non‐neoplastic adult rat hepatocytes in vivo and in culture (1991) (10)
In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice (2015) (9)
Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo (2018) (9)
Induction of P-glycoprotein mRNA by protein synthesis inhibition is not controlled by a transcriptional repressor protein in rat and human liver cells. (1995) (7)
A new liver eQTL map from 1,183 individuals provides evidence for novel eQTLs of drug response, metabolic and sex-biased phenotypes. (2019) (7)
Need and potential for predictive tests of hepatic metabolism of anticancer drugs. (2000) (7)
Role of Vitamins A and D in BCR-ABL Arf−/− Acute Lymphoblastic Leukemia (2020) (6)
Mdr 1 Limits CYP 3 A Metabolism in Vivo (2000) (6)
Genetic Variants of Xenobiotic Receptors and their Implications in Drug Metabolism and Pharmacogenetics (2008) (5)
Genetic predictors of inter-individual variability in hepatic CYP 3 A 4 expression (2009) (5)
Development of A Real-Time in Vivo Transcription Assay : Application Reveals Pregnane X Receptor-Mediated Induction of CYP 3 A 4 by Cancer Chemotherapeutic Agents (2002) (5)
Cytochrome P4503A5 and TNF-a genotypes are associated with tacrolimus dosing in pediatric heart transplant patients (2002) (4)
Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes (2021) (4)
Polarized cell cultures for integrated studies of drug metabolism and transport. (2002) (4)
The CYP 2 C 19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP 2 C 19 * 35 and CYP 2 C 19 * 2 Alleles s (2015) (4)
Genetic Predictors of Interindividual Variability in Hepatic (2010) (4)
Genetic variation in Aldo-keto reductase 1 D 1 ( AKR 1 D 1 ) affects the expression and activity of multiple Cytochrome P 450 s ( CYPs ) (2013) (4)
enzyme activities in human liver Systematic genetic and genomic analysis of cytochrome P 450 Material (2010) (4)
A Comprehensive in vitro and in silico Analysis of Antibiotics that Activate PXR and Induce CYP3A4 in Liver and Intestine (2008) (3)
CYP 2 B 6 , CYP 3 A 4 , AND CYP 2 C 19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES (2004) (3)
Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function (2021) (2)
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters (2021) (2)
Degradation of cytochrome P-450 (DEX) is inhibited by troleandomycin in primary monolayer cultures of adult rat hepatocytes (1984) (2)
Title : Predictors of variation in CYP 2 A 6 mRNA , protein , and enzyme activity in a human liver bank : influence of genetic and non-genetic factors (2016) (1)
Genetic variation in aldo‐keto reductase 1D1 (AKR1D1) affects expression and activity of multiple cytochrome P450s (292.1) (2014) (1)
Extracellular matrix regulation of hepatic transcription factors is dependent on cell structure (1992) (1)
MDR1 EXON26 genotype predicts treatment-resistant rejection in lung transplant patients as assessed by logistic regression analysis (2003) (1)
Title: The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in (2008) (0)
Intestinal CYP3A4 and midazolam disposition in vivo show seasonal variation and associate with VDR polymorphisms (2012) (0)
Evolution of the pregnane X receptor: Role of cross‐species differences in biliary bile salts (2005) (0)
Effect of diallyl sulfide (DAS) and diallyl sulfone (DASO sub 2 ) on P-450 2B1 gene expression rat hepatocytes (1992) (0)
DMD #18382 THE INFLUENCE OF CYP3A5 EXPRESSION ON THE EXTENT OF HEPATIC CYP3A INHIBITION IS SUBSTRATE-DEPENDENT: AN IN VITRO-IN VIVO EVALUATION (2007) (0)
Ketamine pharmacokinetics and pharmacodynamics are altered by Pgp and Bcrp efflux transporters in mice (2018) (0)
Dysregulation of intestinal CYP3A4‐dependent 1,25‐dihydroxyvitamin D3 catabolism: a potential mechanism for drug‐induced osteomalacia (2008) (0)
Role of SLC10A1 SNPs in regulating cytochrome P450 expression (2012) (0)
Deoxycytidine Kinase Genotype Influences Leukemia Cell Concentration of Cytarabine 5′-Triphosphate in Pediatric AML Patients. (2007) (0)
P239 - BCRP gene deletion alters the gut microbiome in mice (2020) (0)
Cancer Therapy : Clinical Ontogeny and Sorafenib Metabolism (2012) (0)
Correction to “The Influence of Sex, Ethnicity, and CYP2B6 Genotype on Bupropion Metabolism as an Index of Hepatic CYP2B6 Activity in Humans” (2014) (0)
Identification ofGlucocorticoid-inducible Cytochromes P-450 intheIntestinal MucosaofRatsandMan (1987) (0)
Explaining I nterindividual V ariability o f D ocetaxel Pharmacokinetics a nd P harmacodynamics i n A sians Through P henotyping a nd G enotyping S trategies (2002) (0)
Faculty Opinions recommendation of Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. (2007) (0)
Ontogeny of various solute carrier family (SLC) transporter expression in human pediatric liver biopsies (2005) (0)
Association of BCRP/ABCG2 Phenotypes and Novel promoter and intron 1 SNPs (2007) (0)
DMD056374 695..699 (2014) (0)
P15 - Vitamin D deficiency alters CYP3A gene expression and pharmacokinetics of dexamethasone (2020) (0)
DMD050344 923..931 (2013) (0)
Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice (2021) (0)
Microsoft Word-42679771-file00.docx (2014) (0)
Microsoft Word-30462222-file00.docx (2015) (0)
Genetic variation in aldo‐keto reductase 1D1 (AKR1D1) affects expression and activity of multiple cytochrome P450s (LB595) (2014) (0)

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