Erinna Lee
#111,910
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Singaporean molecular biologist
Erinna Lee's AcademicInfluence.com Rankings
Erinna Leebiology Degrees
Biology
#11806
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#15230
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Molecular Biology
#2550
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#2591
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Biology
Erinna Lee's Degrees
- PhD Molecular Biology Stanford University
Why Is Erinna Lee Influential?
(Suggest an Edit or Addition)According to Wikipedia, Erinna Lee is a Singaporean molecular biologist specializing in apoptosis and autophagy. Early life and education Erinna Lee was born in Singapore and moved to Australia after high school. She was educated at University of Melbourne, studying a BSc in Biochemistry and Molecular Biology from 2000-2004. She studied her PhD at the Walter and Eliza Hall Institute of Medical Research, which was awarded in 2007 by the University of Melbourne. It was during this PhD where she began research on programmed cell death, which would form a large part of her subsequent research career.
Erinna Lee's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak (2007) (1210)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis (2013) (478)
- Structural insights into the degradation of Mcl-1 induced by BH3 domains (2007) (401)
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. (2012) (354)
- TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis (2009) (235)
- The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins (2009) (194)
- Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. (2008) (190)
- Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. (2012) (180)
- A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation (2008) (167)
- Evidence That Focal Adhesion Complexes Power Bacterial Gliding Motility (163)
- Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax (2008) (160)
- Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 (2014) (158)
- High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. (2009) (130)
- Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. (2012) (130)
- A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. (2007) (126)
- BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival (2019) (109)
- Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1 (2005) (103)
- Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis* (2011) (99)
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands* (2009) (87)
- α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. (2015) (84)
- Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer (2016) (64)
- Structure‐Guided Rational Design of α/β‐Peptide Foldamers with High Affinity for BCL‐2 Family Prosurvival Proteins (2013) (62)
- MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib (2016) (56)
- Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes (2011) (55)
- Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. (2013) (55)
- Structural Basis of Bcl‐xL Recognition by a BH3‐Mimetic α/β‐Peptide Generated by Sequence‐Based Design (2011) (53)
- Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA* (2003) (52)
- Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells (2015) (48)
- Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design. (2017) (43)
- Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins (2018) (43)
- The Structural Biology of Bcl-xL (2019) (40)
- ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types (2017) (39)
- Crosstalk between apoptosis and autophagy signaling pathways. (2020) (39)
- The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains* (2014) (38)
- Physiological restraint of Bak by Bcl-xL is essential for cell survival (2016) (37)
- Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics. (2015) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins* (2009) (33)
- Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis. (2014) (33)
- Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. (2011) (31)
- Affinity Maturation of Leukemia Inhibitory Factor and Conversion to Potent Antagonists of Signaling* (2004) (30)
- Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 (2019) (28)
- A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis (2019) (27)
- Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins. (2011) (25)
- Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM (2016) (22)
- The BECN1 N-terminal domain is intrinsically disordered (2016) (22)
- BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux (2016) (17)
- Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues (2011) (15)
- BECLIN1: Protein Structure, Function and Regulation (2021) (14)
- A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma (2021) (11)
- BCL-XL is an actionable target for treatment of malignant pleural mesothelioma (2020) (11)
- Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer (2021) (8)
- Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis. (2015) (6)
- Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers (2021) (6)
- The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma (2020) (6)
- Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy. (2016) (5)
- Diversity in the intrinsic apoptosis pathway of nematodes (2020) (4)
- Influenza A virus infection‐induced macroautophagy facilitates MHC class II‐restricted endogenous presentation of an immunodominant viral epitope (2020) (4)
- Structural biology of the intrinsic cell death pathway: what do we know and what is missing? (2012) (3)
- Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins (2018) (3)
- BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival (2019) (3)
- A preliminary assessment of oral monepantel’s tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors (2020) (2)
- Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. (2021) (2)
- Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death (2022) (1)
- BCL-XL is an actionable target for treatment of malignant pleural mesothelioma (2020) (1)
- MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib (2016) (1)
- Characterization of a novel human BFL-1-specific monoclonal antibody (2019) (1)
- Diversity in the intrinsic apoptosis pathway of nematodes (2020) (1)
- Crystal structure of Bcl-xL in complex with ABT-737 (2007) (1)
- A viral protein unexpectedly mimics the structure and function of pro- survival Bcl-2 (2007) (0)
- Tâm Mignot Motility Evidence That Focal Adhesion Complexes Power Bacterial Gliding (2013) (0)
- Bcl-2 alpha beta-1 LINEAR complex (2015) (0)
- Therapeutic pro-apoptotic BH-3-like molecules and the process of forming and / or selecting the same (2006) (0)
- Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma (2021) (0)
- Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer (2021) (0)
- BakBH3 in complex with sjA (2011) (0)
- Bcl-2 complex with Beclin 1 BH3 domain (2018) (0)
- Bcl-xL bound to alpha beta Puma BH3 peptide 5 (2014) (0)
- A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma (2021) (0)
- Insight into viral inhibition of apoptosis – structures of myxoma virus M11L and vaccinia virus F1L (2008) (0)
- BimL12Y in complex with Mcl-1 (2009) (0)
- Human Bak Q77L (2016) (0)
- Solution Structure of MCL-1 Complexed with NoxaA (2008) (0)
- Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis inBRAFmutant colorectal cancer cells (2019) (0)
- Bcl-2 alpha beta-1 complex (2015) (0)
- Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma (2021) (0)
- The emerging roles of autophagy in intestinal epithelial cells and its links to inflammatory bowel disease. (2023) (0)
- Structure of a Bcl-w dimer (2011) (0)
- Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand (2008) (0)
- Puma BH3 foldamer in complex with Bcl-xL (2011) (0)
- Bcl-xL complex with Beclin 1 BH3 domain T108pThr (2018) (0)
- Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death (2022) (0)
- Crystal structure of BCL-XL in complex with W1191542 (2009) (0)
- Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL (2011) (0)
- alpha/beta foldamer in complex with Bcl-xL (2009) (0)
- JCB: REPORT (2009) (0)
- Characterization of a novel human BFL-1-specific monoclonal antibody (2019) (0)
- Crystal Structure of the myxoma virus anti-apoptotic protein M11L (2007) (0)
- BimL12F in complex with Bcl-xL (2009) (0)
- BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in BRAF mutant colorectal cancer cells (2019) (0)
- Bim BH3 peptide in complex with Bcl-xL (2009) (0)
- Cover Picture: Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design (ChemBioChem 13/2011) (2011) (0)
- How programmed cell death is regulated: insights from structures of Bcl-2 family protein complexes (2008) (0)
- Bcl-2 complex with Beclin 1 T108D BH3 domain (2018) (0)
- Bcl-xL with mouse Bak BH3 Q75L complex (2016) (0)
- Dual MAPK and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death (2021) (0)
- Bcl-xL with Bak BH3 complex (2016) (0)
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