Ernest Hamel
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Engineering Computer Science
Ernest Hamel's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Mathematics University of California, Berkeley
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(Suggest an Edit or Addition)Ernest Hamel's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4 (1989) (577)
- Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. (1997) (554)
- Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)* (1997) (467)
- 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. (1994) (395)
- Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. (1989) (380)
- Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. (1996) (367)
- 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. (2000) (354)
- Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. (1991) (349)
- Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a) (1995) (337)
- Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula (1994) (283)
- New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. (2006) (282)
- Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. (1987) (279)
- Antimitotic natural products and their interactions with tubulin (1996) (278)
- Requirement of an Escherichia coli 50 S ribosomal protein component for effective interaction of the ribosome with T and G factors and with guanosine triphosphate. (1972) (270)
- Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. (1990) (268)
- A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. (2005) (268)
- Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. (1991) (263)
- Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. (1990) (250)
- Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study. (1988) (248)
- Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. (1990) (238)
- Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. (1998) (229)
- Arylthioindoles, potent inhibitors of tubulin polymerization. (2004) (228)
- Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin (2007) (225)
- The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. (2002) (219)
- Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. (1984) (215)
- The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. (1997) (210)
- Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. (1998) (207)
- Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. (1992) (199)
- One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization. (2002) (197)
- Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. (1995) (191)
- Antineoplastic agents. 379. Synthesis of phenstatin phosphate. (1998) (190)
- Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. (1993) (180)
- Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. (1992) (175)
- Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. (1992) (173)
- Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. (2008) (164)
- Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin. (1981) (163)
- Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones. (2001) (161)
- Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization. (1999) (158)
- Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. (2005) (152)
- Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. (2002) (151)
- Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine (*) (1996) (150)
- Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. (2007) (148)
- Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. (2002) (145)
- Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues. (2010) (143)
- A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents. (2001) (142)
- Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. (2007) (138)
- The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. (1999) (138)
- Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. (2005) (132)
- Colchicine and its analogues: Recent findings (1988) (129)
- Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. (2011) (129)
- Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. (1993) (123)
- Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. (1996) (122)
- Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells† (1997) (121)
- Structure-activity requirements for flavone cytotoxicity and binding to tubulin. (1998) (120)
- Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. (1992) (118)
- Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. (2001) (118)
- Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization. (2007) (116)
- Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization. (1981) (110)
- Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. (2000) (110)
- EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1 (2008) (106)
- Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly (2006) (106)
- Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity. (2012) (106)
- Design, synthesis, and biological evaluation of thiophene analogues of chalcones. (2008) (103)
- The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. (2005) (102)
- The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain. (1995) (101)
- MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. (2012) (99)
- The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. (2001) (98)
- Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin (2006) (97)
- Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. (1994) (96)
- Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents. (1994) (95)
- Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. (2000) (92)
- Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin. (2003) (91)
- Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers. (1996) (90)
- Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges. (1999) (88)
- Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. (2013) (88)
- Isolation and Structure of Halistatin 1 from the Eastern Indian Ocean Marine Sponge Phakellia carteri (1993) (86)
- A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. (2010) (85)
- Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. (1996) (85)
- Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. (1995) (84)
- Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. (2005) (84)
- Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth. (1997) (83)
- Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents. (2011) (82)
- Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors. (2008) (81)
- Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. (2000) (81)
- Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1. (1999) (80)
- Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354. (2000) (79)
- Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. (1997) (78)
- A new anti-tubulin agent containing the benzo[b]thiophene ring system. (1999) (78)
- Interactions of combretastatin, a new plant-derived antimitotic agent, with tubulin. (1983) (75)
- Centaureidin, a cytotoxic flavone from Polymnia fruticosa, inhibits tubulin polymerization (1993) (75)
- Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogs with Increased Activities (1994) (75)
- New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies. (2009) (72)
- Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum. (1988) (71)
- Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. (2012) (71)
- Effects of inhibitors of tubulin polymerization on GTP hydrolysis. (1981) (69)
- Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure. (2018) (69)
- Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously. (2004) (69)
- Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications. (1995) (69)
- Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. (2013) (69)
- The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4. (2007) (68)
- Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction. (1996) (68)
- Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4. (1999) (67)
- Actin is the primary cellular receptor of bistramide A (2005) (67)
- Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin. (2000) (67)
- Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. (1997) (67)
- Antimitotic peptides and depsipeptides. (2012) (66)
- Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198 (2008) (66)
- Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. (2005) (66)
- 4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents. (2006) (66)
- Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. (2010) (64)
- Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization. (1997) (64)
- Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. (2011) (63)
- Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization. (2009) (63)
- Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. (1998) (62)
- New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. (2014) (62)
- Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin. (2001) (62)
- Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. (1999) (61)
- Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability. (2000) (61)
- Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity. (1993) (61)
- Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones. (2004) (61)
- The effects of chelidonine on tubulin polymerisation, cell cycle progression and selected signal transmission pathways. (2001) (57)
- Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action. (2012) (57)
- Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10. (1990) (57)
- Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. (2009) (57)
- Antineoplastic agents 365. Dolastatin 10 SAR probes. (1998) (55)
- Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol). (1998) (54)
- Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. (1995) (54)
- Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography. (1989) (54)
- Synthesis and Biological Evaluation of Novel Paclitaxel (Taxol) D-Ring Modified Analogues. (1999) (53)
- Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents. (2012) (53)
- Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. (2012) (53)
- A steroid derivative with paclitaxel-like effects on tubulin polymerization. (2000) (52)
- Stabilization of the colchicine-binding activity of tubulin by organic acids. (1981) (52)
- Evolution of the total syntheses of ustiloxin natural products and their analogues. (2008) (52)
- Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. (2015) (52)
- Interactions of Halichondrin B and Eribulin with Tubulin (2011) (51)
- Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents. (2006) (51)
- Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors. (2006) (51)
- Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly. (1984) (51)
- Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi. (2003) (51)
- Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions. (1992) (51)
- Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). (2013) (50)
- Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity. (2013) (50)
- Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. (1995) (50)
- 2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization. (2009) (49)
- Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug. (1998) (49)
- Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. (2005) (49)
- Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides. (2003) (48)
- Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. (1985) (48)
- Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles. (2014) (47)
- Convergent syntheses of the pyrrolic marine natural products lamellarin-O, lamellarin-Q, lukianol-A and some more highly oxygenated congeners (1997) (47)
- Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. (2003) (47)
- Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors. (2014) (47)
- Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization. (2004) (46)
- N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties. (1990) (46)
- Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site (2014) (46)
- Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. (2007) (46)
- (−)-Doliculide, a New Macrocyclic Depsipeptide Enhancer of Actin Assembly* (2002) (45)
- Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. (2010) (45)
- The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer (2009) (45)
- Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization. (1993) (45)
- Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents. (1997) (45)
- Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin. (2015) (44)
- N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. (2013) (44)
- Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine. (1987) (44)
- Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). (2005) (43)
- Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. (2013) (42)
- Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent. (1993) (41)
- Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. (1990) (41)
- Identification and Characterization of a New Tubulin-Binding Tetrasubstituted Brominated Pyrrole (2007) (41)
- Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters. (2003) (41)
- A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp. (2003) (41)
- Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation. (2009) (41)
- The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. (2014) (41)
- Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. (2013) (40)
- Benzoylphenylurea sulfur analogues with potent antitumor activity. (2006) (40)
- Antineoplastic agents 300. Isolation and structure of the rare human cancer inhibitory macrocyclic lactones spongistatins 8 and 9 (1994) (40)
- Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids. (2013) (39)
- Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1, 2-dihydroxy- 1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3' ',4' ',5' '-trimethoxyphenyl)-ethane. (2000) (39)
- Interactions of antimitotic peptides and depsipeptides with tubulin. (2002) (39)
- Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly. (2009) (39)
- Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. (2005) (38)
- Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. (2010) (38)
- Deoxyguanosine nucleotide analogues: potent stimulators of microtubule nucleation with reduced affinity for the exchangeable nucleotide site of tubulin. (1984) (38)
- E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. (2009) (37)
- Effects of organic acids on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis. (1982) (37)
- New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. (2015) (37)
- A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4. (2009) (37)
- Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization. (2008) (36)
- Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors. (2010) (36)
- The magnesium-GTP interaction in microtubule assembly. (1994) (36)
- Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues. (2013) (35)
- Role of guanine nucleotides in protein synthesis. Elongation factor G and guanosine 5'-triphosphate,3'-diphosphate. (1973) (35)
- Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents. (2010) (35)
- The Palladium-Mediated Cross Coupling of Bromotropolones With Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogs (1991) (35)
- A convenient tubulin-based quantitative assay for paclitaxel (Taxol) derivatives more effective in inducing assembly than the parent compound (1996) (34)
- Antitumor Agents. Part 184. Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids†‡ (1998) (34)
- The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A (2010) (34)
- Studies on the role of an Escherichia coli 50 S ribosomal component in polypeptide chain elongation. (1972) (34)
- Antitumor Agents. 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids (1998) (34)
- Induction of polymerization of purified tubulin by sulfonate buffers. Marked differences between 4-morpholineethanesulfonate (Mes) and 1,4-piperazineethanesulfonate (Pipes). (1981) (34)
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- Synthesis and biological activity of a novel C4–C6 bridged paclitaxel analog (1999) (6)
- Nucleotide interconversions in microtubule protein preparations, a significant complication for accurate measurement of GTP hydrolysis in the presence of adenosine 5'-(beta, gamma-imidotriphosphate). (1987) (6)
- Interactions of Tubulin with Guanine Nucleotides That Have Paclitaxel-like Effects on Tubulin Assembly: 2′,3′-Dideoxyguanosine 5′-[α,β-Methylene] Triphosphate Guanoine 5′-[α,β-Methylene] Triphosphate, and 2′,3′-Dideoxyguanosine 5′-Triphosphate (1995) (6)
- Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation. (2016) (6)
- Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells. (2010) (5)
- Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues. (2013) (5)
- Cover Picture: Tetrahydroisoquinolinone‐Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014) (2014) (5)
- 2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action. (2013) (5)
- 3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with Tubulin. (2017) (5)
- Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives. (2010) (5)
- Synthesis of deoxyguanosine polyphosphates and their interactions with the guanosine 5'-triphosphate requiring protein synthetic enzymes of Escherichia coli. (1975) (5)
- Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in Vitro and in Vivo evaluation as antitumor agents. (2021) (5)
- Evaluation of [1,2]oxazolo[5,4-e]isoindoles in lymphoma cells (2020) (5)
- Unexpectedly Facile Hydrolysis of the 2-Benzoate Group of Taxol and Syntheses of Analogues with Increased Activities. (1994) (5)
- Antitumor Agents. Part 226. Synthesis and Cytotoxicity of 2‐Phenyl‐4‐quinolone Acetic Acids and Their Esters (2003) (5)
- Studies directed towards total syntheses of the tropoloisoquinoline alkaloids grandirubrine and imerubrine. Part 2. Thermolysis of 8,9-dihydro-2-hydroxy-3,10,11,12-tetra methoxyisoquino[2,1-c][1,2,3]benzotriazin-7-ium chloride: competitive modes of cyclisation leading to the indeno[1,2,3-ij]isoquino (1993) (5)
- Antifungal and cancer cell growth inhibitory activities of 1‐(3′,4′,5′‐trimethoxyphenyl)‐2‐nitro‐ethylene (2002) (5)
- A New Anti‐Tubulin Agent Containing the Benzo[b]thiophene Ring System. (1999) (4)
- Antitumor Agents. Part 174. 2′,3′,4′,5,6,7-Substituted 2-Phenyl-1,8- naphthyridin-4-ones: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization. (1997) (4)
- Antitumor Agents. Part 183. Syntheses, Conformational Analyses, and Antitubulin Activity of Allothiocolchicinoids. (1998) (4)
- (-)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin. (2016) (4)
- Reaction of colchiceinamide with phosgene and with thiophosgene : structures and antitubulin activity of tetracyclic oxazolones, oxazolethiones and thiazolones of the colchicine series (1990) (4)
- Interaction of diazonamide a with tubulin. (2019) (4)
- Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. (2002) (4)
- The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. (2020) (4)
- Synthesis of 14C labelled electrophilic ligands of the colchicine binding site of tubulin: Chloroacetates of demethylthiocolchicines and of N‐acetylcolchinol; isothiocyanate of 9‐deoxy‐N‐acetylcolchinol (1993) (4)
- The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. (2013) (4)
- A Novel Palladium‐Mediated Coupling Approach to 2,3‐Disubstituted Benzo[b]thiophenes and Its Application to the Synthesis of Tubulin Binding Agents. (2001) (4)
- Erratum: Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance (Journal of Medicinal Chemistry (2010) 53 (8116) DOI: 10.1021/jm101010n) (2011) (3)
- Synthesis and biological evaluation of 2-amino-3-(3', 4', 5'-trimethoxy-phenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents. (2007) (3)
- Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents. (2019) (3)
- Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6. [Erratum to document cited in CA122:290568] (1995) (3)
- SYNTHESIS AND BIOLOGICAL ACTIVITY OF SULFUR COMPOUNDS SHOWING STRUCTURAL ANALOGY WITH COMBRETASTATIN A-4. (2013) (3)
- Convergent Syntheses of the Pyrrolic Marine Natural Products Lamellarin-O, Lamellarin-Q, Lukianol-A, and Some More Highly Oxygenated Congeners. (1997) (3)
- Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors. (1998) (3)
- Antineoplastic Agents. Part 252. Isolation and Structure of Halistatin 2 from the Comoros Marine Sponge Axinella carteri (1993) (3)
- Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation (2014) (3)
- Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents (2022) (3)
- Derivatives of guanosine triphosphate with ribose 2'-hydroxyl substituents. Interactions with the protein synthetic enzymes of Escherichia coli. (1976) (3)
- Structure of Curacin A (I), a Novel Antimitotic, Antiproliferative, and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula. (1994) (3)
- Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogues of 2‐Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol that Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site. (1995) (3)
- Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents. (2018) (3)
- Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide. (2019) (2)
- Addendum. Antitumor Agents, 154. Cytotoxic and Antimitotic Flavonols from Polanisia dodecandra (1995) (2)
- New Antineoplastic Agents with Antitubulin Activity (1986) (2)
- Interactions of tubulin with guanine nucleotides that have paclitaxel-like effects on tubulin assembly: 2',3'-dideoxyguanosine 5'-[alpha,beta-methylene]triphosphate, guanosine 5'-[alpha,beta-methylene]triphosphate, and 2',3'-dideoxyguanosine 5'-triphosphate. (1995) (2)
- Reaction of Colchiceinamide with Phosgene and with Thiophosgene: Structures and Antitubulin Activity of Tetracyclic Oxazolones, Oxazolethiones, and Thiazolones of the Colchicine Series. (1991) (2)
- Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents (2020) (2)
- Synthesis and Evaluation of Analogues of Z‐1‐(4‐Methoxyphenyl)‐2‐(3,4, 5‐trimethoxyphenyl)ethene as Potential Cytotoxic and Antimitotic Agents. (1992) (2)
- Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. (2019) (2)
- SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS. (2012) (2)
- Preclinical Development Peloruside-and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have b I-Tubulin Mutations and Altered Expression of b II-and b III-Tubulin Isotypes (2011) (2)
- Synthesis and Tubulin-Binding Properties of Some AC- and ABC-Ring Analogues of Allocolchicine. (2010) (2)
- Synthesis and tubulin interaction of thiocolchicines containing an isothiocyanato group. Synthesis of C(2)-deuterated and C(2)-14C-labeled 7-isothiocyanatodeacetamidothiocolchicine (1991) (2)
- ChemInform Abstract: One-Pot Synthesis of Benzo[b]furan and Indole Inhibitors of Tubulin Polymerization. (2002) (2)
- S‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent (2019) (1)
- Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents (2022) (1)
- Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor (2022) (1)
- Synthesis and Biological Evaluation of 4-Deacetylpaclitaxel. (1995) (1)
- Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents. (2021) (1)
- Interactions of Tubulin with Small Ligands (2018) (1)
- Synthesis of two fluorescent GTPγS molecules and their biological relevance (2017) (1)
- Abstract C097: Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles: A new class of antimitotic agents (2019) (1)
- New complex polycyclic compounds: Synthesis, antiproliferative activity and mechanism of action. (2020) (1)
- Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation. (2010) (1)
- Abstract #5570: Interaction of [³H]halichondrin B with tubulin (2009) (1)
- Synthesis of Cryptothilone 1, the First Cryptophycin—Epothilone Hybrid. (2007) (1)
- Synthesis, X-Ray Crystal Structure, and Antimitotic Properties of 6-Chloro-2-methoxy-5-(2′,3′,4′-trimethoxyphenyl)cyclohepta-2,4,6-trien-1-one, a Bicyclic Analogue of Colchicine. (1989) (1)
- Colchicine Models: Synthesis and Binding to Tubulin of Tetramethoxybiphenyls. (1988) (1)
- Preparation of New Anti-Tubulin Ligands Through a Dual-Mode, Addition—Elimination Reaction to a Bromo-Substituted α,β-Unsaturated Sulfoxide. (2001) (1)
- Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential. (2013) (1)
- Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. (2021) (1)
- Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities (2022) (1)
- Antitumor Agents. Part 172. Synthesis and Biological Evaluation of Novel Deacetamidothiocolchicin‐7‐ols and Ester Analogues as Antitubulin Agents. (1997) (1)
- The Palladium-Mediated Cross Coupling of Bromotropolones with Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogues. (1991) (1)
- Arylcarbonlyindoles: Antimitotic Agents and Potent Inhibitors of Tubulin Polymerization. (2007) (0)
- Antitumor Agents. Part 184. Syntheses and Antitubulin Activity of Compounds Derived from Reaction of Thiocolchicone with Amines: Lactams, Alcohols, and Ester Analogues of Allothiocolchicinoids. (1998) (0)
- Abstract 1665: Design, synthesis, biological evaluation of cyclopenta[d]pyrimidines as antitubulin agents and discovery of N-(4-methylthiophenyl) and N-(4-dimethylaminophenyl) substituted N,2-dimethyl-cyclopenta[d]pyrimidines as long acting and poten (2015) (0)
- Abstract 836: Potent antitubulin and antitumor activities influenced by the 3-D conformational shape of bicyclic fused pyrimidines (2014) (0)
- DDIS-29. BRAIN-PENETRANT MICROTUBULE-TARGETING AGENT, ST-401, KILLS GLIOBLASTOMA THROUGH A NOVEL MECHANISM (2019) (0)
- Abstract 1622: Design and preclinical evaluation of single agents with tubulin and multiple receptor tyrosine kinase inhibition (2014) (0)
- Total Synthesis of (.+-.)-Rhazinal, an Alkaloidal Spindle Toxin from Kopsia teoi. (2003) (0)
- Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site. (2023) (0)
- Synthesis and Tubulin Interaction of Thiocolchicines Containing an Isothiocyanato Group. Synthesis of C(2)-Deuterated and C(2)-14C- Labeled 7-Isothiocyanatodeacetamidothiocolchicine. (1992) (0)
- RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo. (2022) (0)
- Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation (2014) (0)
- Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide. (2000) (0)
- Abstract 3889: Substituted pyrrolo[2,3-d]pyrimidines as water soluble microtubule targeting agents (2012) (0)
- Antitumor Agents. Part 150. 2′,3′,4′,5′,5,6,7-Substituted 2-Phenyl-4- quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization. (1994) (0)
- Tetra and Pentapeptide Derivatives of Hemiasterlin. Synthesis and Activity Studies (2006) (0)
- Direct incorporation of GDP into microtubules without GTP hydrolysis (1987) (0)
- Regiocontrolled Total Syntheses of the Tropoloisoquinoline Alkaloids Imerubrine and Grandirubrine. (1995) (0)
- 3-Aroyl-1-arylpyrroles: a New Class of Potent Inhibitors of Tubulin Polymerization. (2014) (0)
- Abstract 4553: Substituted monocyclic pyrimidines as potent tubulin inhibitors that circumvent P-glycoprotein mediated resistance (2015) (0)
- Colchicine Models: Synthesis and Antitubulin Activity of 2′‐Monosubstituted and 2′,5‐Disubstituted 2,3,4,4′‐Tetramethoxy‐1,1′‐biphenyls. Synthesis of 4,4′,5′,6′‐Tetramethoxy‐1,1′‐biphenyl‐2,3′‐dicarboxylic Acid. (1989) (0)
- 2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition (2022) (0)
- Natural Products. Antitubulin Effect of Congeners of N-Acetylcolchinyl Methyl Ether: Synthesis of Optically Active 5- Acetamidodeaminocolchinyl Methyl Ether and of Demethoxy Analogues of Deaminocolchinyl Methyl Ether. (1993) (0)
- Total Synthesis and Biological Evaluation of Ustiloxin Natural Products and Two Analogues. (2007) (0)
- Dideoxyguanosine Nucleotides and Microtubule Assembly (1986) (0)
- The marine compound Lasonolide A is a potent inducer of premature chromosome condensation and inhibitor of cell adhesion (2007) (0)
- Synthesis and Biological Evaluation of a Spongistatin AB‐Spiroketal Analogue. (2002) (0)
- Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas. (2023) (0)
- Deguelin, a plant-derived rotenoid, mediates potent chemopreventive responses through transcriptional regulation of phorbol ester-induced (2006) (0)
- Antitumor Agents. Part 215. Antitubulin Effects of Cytotoxic B‐Ring Modified Allocolchicinoids. (2003) (0)
- Corrigendum to "The interaction of spongistatin 1 with tubulin" [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)]. (2022) (0)
- Ernest Hamel and Tokumasa Nakamoto Polypeptide Chain Elongation 50 S Ribosomal Component in Escherichia coli Studies on the Role of an (2003) (0)
- Total Syntheses of the Structures Assigned to Salimine and Jerusalemine, Alkaloids from Colchicum decaisnei Boiss. (Liliaceae). (2010) (0)
- Synthesis and Biological Evaluation of 4‐Deacetoxypaclitaxel. (1995) (0)
- Progress in the development of arylthioindoles, potent inhibitors of tubulin polymerization and MCF-7 cell growth. (2008) (0)
- Design, synthesis and evaluation of microtubule inhibitors phenoxy pyridine (PP) and phenyl sulfanyl pyridine (PSP) analogs for cancer therapy (2007) (0)
- Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents (2012) (0)
- 1 Synthesis , Antimitotic and Antivascular Activity of 1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-3-Arylamino-5-Amino-1 , 2 , 4-Triazoles (2015) (0)
- Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP. (2009) (0)
- EXTH-53. A BRAIN-PENETRANT MICROTUBULE-TARGETING AGENT THAT DISRUPTS HALLMARKS OF GLIOMA TUMORIGENESIS (2020) (0)
- NEW 4-DIAZOPYRAZOLE DERIVATIVES AS POTENTIAL ANTIBIOFILM AGENTS (2010) (0)
- Abstract 2477: Design, synthesis and biological evaluation of substituted monocyclic pyrimidines as potent microtubule targeting antitumor agents that circumvent Pgp and βIII-tubulin-mediated resistance. (2011) (0)
- Synthesis and Biological Activity of a Novel C4—C6 Bridged Paclitaxel Analogue. (1999) (0)
- Discovery of a novel class of anti-proliferative pyrrolo[3,2-f]quinolin-9-ones characterized by interfering with both PI3K-Akt-mTOR signalling and microtubule assembling (2012) (0)
- Antitumor Agents. Part 181. Synthesis and Biological Evaluation of 6,7,2′,3′,4′-Substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a New Class of Antimitotic Antitumor Agents. (1998) (0)
- Integrating disciplines in the natural products sciences: The story of Curacin A (2012) (0)
- Abstract 4492: Structure-activity relationship study anti-microtubule agents targeting the colchicine site on tubulin that circumvent drug resistance. (2013) (0)
- Erratum: Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site (Biochemistry (August 30, 2005) 44, 34 (11525-11538)) (2006) (0)
- Corrigendum to “Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones” (Eur. J. Med. Chem. 39 (2004) 299–304) (2004) (0)
- Direct photoaffinity labeling of tubulin by [H-3]dolastatin (1999) (0)
- Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives (2019) (0)
- Novel Indole-Pyrazole Hybrids as Potential Tubulin-Targeting Agents; Synthesis, antiproliferative evaluation, and molecular modeling studies (2023) (0)
- Convergent Synthesis and Preliminary Biological Evaluation of (.+‐.)‐B‐Norrhazinal. (2000) (0)
- Synthesis of (+)-Chamaecypanone C (2009) (0)
- Transcriptome and computational analysis assess the anti-tubulin activity of [1,2]oxazole derivatives in lymphoma (2022) (0)
- In vitro conditions promoting the formation of both microtubules and spirals by the natural product (-)-rhazinilam (2004) (0)
- Synthesis of Analogues of 2‐Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth. (1997) (0)
- The interaction of spongistatin 1 with tubulin. (2022) (0)
- Arylthioindoles: Design, Synthesis and Biological Activity (2007) (0)
- Tubulin-STX3451 complex (2019) (0)
- 1 Design , Synthesis , in Vitro and in Vivo Biological Evaluation of 2-Amino-3-Aroylbenzo [ b ] furan Derivatives as Highly Potent Tubulin Polymerization Inhibitors (2022) (0)
- Abstract 3897: Design and preclinical evaluation of single agents with antitubulin and antiangiogenic activity as antitumor agents (2012) (0)
- Front Cover: 2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition (ChemMedChem 23/2022) (2022) (0)
- Arylthioindole Bioisosteres as Potent Tubulin Polymerization and MCF-7 Cell Growth Inhibitors (2009) (0)
- N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization. (2014) (0)
- Antitumor Agents. Part 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids. (1999) (0)
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What Schools Are Affiliated With Ernest Hamel?
Ernest Hamel is affiliated with the following schools:
- University of California, Berkeley
- Cardiff University
- Arizona State University
- University of Bradford
- University of Antwerp
- University of Milan
- Oregon State University
- Victoria University of Wellington
- Stanford University
- Purdue University
- University of Pittsburgh
- University of North Carolina at Chapel Hill
- University of Bologna
- Australian National University
- University of Utah
- University of Pennsylvania
- Harvard University
