Ernesto Canalis
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Computer Science
Ernesto Canalis's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science University of California, Berkeley
- Bachelors Computer Science University of California, Berkeley
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(Suggest an Edit or Addition)Ernesto Canalis's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Glucocorticoid-induced osteoporosis: pathophysiology and therapy (2007) (956)
- Bone morphogenetic proteins, their antagonists, and the skeleton. (2003) (875)
- Growth hormone, insulin-like growth factors, and the skeleton. (2008) (781)
- Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. (1988) (627)
- Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. (1987) (624)
- Growth factors and the regulation of bone remodeling. (1988) (614)
- Mechanisms of anabolic therapies for osteoporosis. (2007) (599)
- Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. (1989) (526)
- Age‐Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice (2007) (493)
- The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. (1996) (489)
- Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. (1996) (457)
- Glucocorticoid-induced osteoporosis: an update (2006) (453)
- Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. (1989) (422)
- Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria. (1980) (391)
- Effects of basic fibroblast growth factor on bone formation in vitro. (1988) (377)
- Direct stimulation of bone resorption by thyroid hormones. (1976) (358)
- Bone morphogenetic proteins and their antagonists (2007) (356)
- Mechanisms of glucocorticoid action in bone (2005) (343)
- Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. (1989) (329)
- Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. (1998) (328)
- Mechanisms of Glucocorticoid Action in Bone (2002) (277)
- Drug-induced osteoporosis: mechanisms and clinical implications. (2010) (246)
- Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches (2013) (239)
- Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae. (1983) (238)
- Skeletal growth factors. (2000) (230)
- Perspectives on glucocorticoid-induced osteoporosis. (2004) (228)
- Effects of platelet‐derived growth factor on bone formation in vitro (1989) (214)
- Transforming growth factor-beta and remodeling of bone. (1991) (212)
- Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling* (2006) (212)
- Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin. (1976) (210)
- The hormonal and local regulation of bone formation. (1983) (210)
- Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. (1991) (198)
- Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae. (1986) (195)
- Further biochemical and molecular characterization of primary rat parietal bone cell cultures (1988) (192)
- Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells. (1990) (188)
- Notch inhibits osteoblast differentiation and causes osteopenia. (2008) (188)
- Transforming growth factor-beta stimulates bone matrix apposition and bone cell replication in cultured fetal rat calvariae. (1990) (187)
- Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts. (1994) (185)
- Skeletal overexpression of noggin results in osteopenia and reduced bone formation. (2003) (185)
- Growth factors and cytokines in bone cell metabolism. (1991) (183)
- Management of endocrine disease: Secondary osteoporosis: pathophysiology and management. (2015) (181)
- Characterization of the effect of insulin on collagen synthesis in fetal rat bone. (1985) (181)
- Notch Signaling and the Skeleton. (2016) (180)
- Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae. (1988) (179)
- Direct stimulation of bone resorption by epidermal growth factor. (1980) (178)
- Notch 1 impairs osteoblastic cell differentiation. (2003) (177)
- A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity (2008) (176)
- Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. (2005) (172)
- Interleukin-1 has independent effects on deoxyribonucleic acid and collagen synthesis in cultures of rat calvariae. (1986) (171)
- Effects of glucocorticoids on fetal rat bone collagen synthesis in vitro. (1979) (168)
- Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae. (1988) (165)
- Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. (2002) (165)
- Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone (1991) (164)
- Cortisol downregulates osteoblast α1(I) procollagen mRNA by transcriptional and posttranscriptional mechanisms (1995) (159)
- Skeletal tissue and transforming growth factor β (1988) (158)
- Effect of growth factors on bone cell replication and differentiation. (1985) (156)
- Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. (2001) (155)
- Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae. (1985) (155)
- Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. (2003) (153)
- Notch and the Skeleton (2009) (148)
- Glucocorticoid suppression of IGF I transcription in osteoblasts. (2001) (144)
- Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures. (1990) (141)
- New understanding and treatments for osteoporosis (2012) (140)
- Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells. (1989) (139)
- Glucocorticoid-induced osteoporosis: summary of a workshop. (2001) (138)
- Mechanisms of glucocorticoid action in bone cells (1994) (136)
- Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters. (2002) (135)
- Effects of tumor necrosis factor on bone formation in vitro. (1987) (133)
- Insulin-like growth factor (IGF) and bone. (1989) (132)
- Infrared Analysis of the Mineral and Matrix in Bones of Osteonectin‐Null Mice and Their Wildtype Controls (2003) (130)
- Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth factors (1994) (130)
- Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria. (1981) (129)
- Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway (2019) (128)
- Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells (1990) (125)
- Hormonal control of bone collagen synthesis in vitro. Effects of insulin and glucagon. (1977) (124)
- Tumor necrosis factor-alpha inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxyribonucleic acid synthesis in osteoblast-enriched bone cell cultures. (1988) (122)
- Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. (1995) (120)
- Studies of hormonal regulation of osteocalcin synthesis in cultured fetal rat calvariae. (1985) (120)
- Growth factor control of bone mass (2009) (116)
- Local regulators of skeletal growth: a perspective. (1985) (116)
- Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice. (2008) (116)
- Insulin like growth factors and the local regulation of bone formation. (1992) (111)
- Cortisol Increases Interstitial Collagenase Expression in Osteoblasts by Post-transcriptional Mechanisms (*) (1995) (110)
- Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone. (1990) (110)
- Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. (1993) (108)
- Conditional Deletion of Gremlin Causes a Transient Increase in Bone Formation and Bone Mass* (2007) (107)
- Serum IGF‐1 Determines Skeletal Strength by Regulating Subperiosteal Expansion and Trait Interactions (2009) (106)
- Osteoblast lineage-specific effects of notch activation in the skeleton. (2013) (106)
- Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I. (1993) (104)
- Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia. (2002) (103)
- Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures. (1995) (102)
- Effect of epidermal growth factor on bone formation in vitro. (1979) (101)
- Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria. (1980) (101)
- Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae. (1983) (98)
- Hormonal control of bone collagen synthesis in vitro: inhibitory effect of 1-hydroxylated vitamin D metabolites. (1978) (97)
- Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone. (1988) (97)
- Mechanisms of glucocorticoid induced osteoporosis (2003) (92)
- Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts1 (2000) (92)
- Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone. (1989) (92)
- Expression and regulation of CCN genes in murine osteoblasts. (2006) (92)
- Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling* (2013) (90)
- Cellular and clinical perspectives on skeletal insulin‐like growth factor I (1994) (90)
- The role of growth factors in skeletal remodeling. (1989) (89)
- CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. (2004) (88)
- Cortisol regulates the expression of Notch in osteoblasts (2002) (87)
- The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. (2006) (85)
- Update in new anabolic therapies for osteoporosis. (2010) (84)
- Interleukin-6 and Its Soluble Receptor Cause a Marked Induction of Collagenase 3 Expression in Rat Osteoblast Cultures* (1997) (83)
- Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone (1991) (81)
- Cortisol Inhibits the Synthesis of Insulin-like Growth Factor-binding Protein-5 in Bone Cell Cultures by Transcriptional Mechanisms (*) (1996) (79)
- A bone-derived growth factor isolated from rat calvariae is beta 2 microglobulin. (1987) (79)
- Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet‐derived growth factor in osteoblast‐enriched cultures from fetal rat bone (1991) (79)
- Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells. (1989) (77)
- Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells. (1995) (76)
- Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2* (1999) (75)
- Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. (2000) (75)
- Age-Related Changes in Trabecular Architecture Differ in Female and Male C 57 BL / 6 J Mice * (2007) (71)
- The fate of circulating osteoblasts. (2005) (71)
- Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone. (1992) (71)
- Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor. (2014) (71)
- Hajdu-Cheney syndrome: a review (2014) (70)
- Role of platelet derived growth factor in bone cell function. (1992) (70)
- Effects of endothelial cell growth factor on bone remodelling in vitro. (1987) (68)
- Nephroblastoma Overexpressed (Nov) Inhibits Osteoblastogenesis and Causes Osteopenia* (2007) (67)
- Differential effects of continuous and transient treatment with parathyroid hormone related peptide (PTHrp) on bone collagen synthesis. (1990) (66)
- Mitogenesis in fetal rat bone cells simultaneously exposed to type β transforming growth factor and other growth regulators (1987) (65)
- Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage. (1995) (65)
- Transforming growth factor β1 inhibits collagenase 3 expression by transcriptional and post‐transcriptional mechanisms in osteoblast cultures (1997) (63)
- Notch Signaling in Osteoblasts (2008) (63)
- PPARG by Dietary Fat Interaction Influences Bone Mass in Mice and Humans (2008) (63)
- Insulin-like growth factors and osteoporosis. (1997) (62)
- Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption*♦ (2015) (62)
- Mechanisms of glucocorticoid-induced osteoporosis. (2003) (60)
- Regulation of insulin‐like growth factors I and II and their binding proteins in human bone marrow stromal cells by dexamethasone (1998) (59)
- Regulation of insulin-like growth factor-II production in bone cultures. (1991) (59)
- MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis. (2018) (58)
- Effect of sodium vanadate on deoxyribonucleic acid and protein syntheses in cultured rat calvariae. (1985) (58)
- Notch signaling in skeletal health and disease. (2013) (57)
- Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures. (1997) (57)
- Beta 2-microglobulin enhances insulin-like growth factor I receptor levels and synthesis in bone cell cultures. (1989) (56)
- The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton* (2011) (55)
- Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells. (1995) (55)
- Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells. (1997) (55)
- Skeletal Growth Factors Regulate the Synthesis of Insulin-like Growth Factor Binding Protein-5 in Bone Cell Cultures (*) (1995) (54)
- Notch in skeletal physiology and disease (2018) (53)
- Bone morphogenetic protein 2 increases insulin‐like growth factor I and II transcripts and polypeptide levels in bone cell cultures (1994) (53)
- The epidemiology of partialandrogen deficiency in aging men (PADAM). (2005) (53)
- Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders (2012) (53)
- Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts. (1996) (53)
- Hormonal regulation of bone formation. (1978) (52)
- Effect of fibroblast growth factor on cultured fetal rat calvaria. (1980) (52)
- Effect of somatomedin and growth hormone on bone collagen synthesis in vitro. (1977) (51)
- Glucocorticoid‐induced osteoporosis in rheumatic diseases (2010) (51)
- Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTLs With Sex‐Dependent Regulation of Bone Phenotypes (2007) (51)
- Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells. (1994) (51)
- Isolation of EGF‐dependent transforming growth factor (TGFβ‐like) activity from culture medium conditioned by fetal rat calvariae (1987) (50)
- Connective Tissue Growth Factor Enhances Osteoblastogenesis in Vitro* (2008) (50)
- A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength (2012) (50)
- Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts. (1999) (49)
- Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. (2008) (49)
- Bone loss or lost bone: Rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss (2009) (48)
- Clinical review 35: Growth factors and their potential clinical value. (1992) (48)
- AU-Rich Elements in the Collagenase 3 mRNA Mediate Stabilization of the Transcript by Cortisol in Osteoblasts* (2004) (48)
- Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. (1997) (47)
- Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts. (2000) (47)
- Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures. (1994) (46)
- Sex and Genetic Factors Determine Osteoblastic Differentiation Potential of Murine Bone Marrow Stromal Cells (2014) (46)
- Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors. (1994) (45)
- New treatment modalities in osteoporosis. (2010) (45)
- Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast‐enriched cells (1992) (45)
- Bone morphogenetic protein‐4 regulates its own expression in cultured osteoblasts (2000) (44)
- Transforming growth factor-β increases interleukin-6 transcripts in osteoblasts (2000) (44)
- C/EBP homologous protein is necessary for normal osteoblastic function (2006) (44)
- Determination and expression of platelet-derived growth factor-AA in bone cell cultures. (1992) (44)
- HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass* (2010) (44)
- Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells. (1995) (44)
- Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures. (1996) (43)
- Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts. (1999) (43)
- Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects. (2007) (42)
- Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site. (2000) (42)
- Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts* (2010) (42)
- Retinoic acid stimulates the transcription of insulin‐like growth factor binding protein‐6 in skeletal cells (1996) (40)
- Effects of activated T cells on osteoclastogenesis depend on how they are activated. (2004) (40)
- Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. (2009) (39)
- Hajdu Cheney Syndrome; report of a novel NOTCH2 mutation and treatment with denosumab. (2016) (39)
- Constitutive synthesis of insulin-like growth factor-II by primary osteoblast-enriched cultures from fetal rat calvariae. (1992) (39)
- Insulin‐like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures (1997) (38)
- Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors. (1996) (38)
- Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. (2010) (38)
- Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts. (2000) (38)
- Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease. (2003) (37)
- Secondary osteoporosis : pathophysiology and management (2015) (37)
- Skeletal growth factors and aging. (1994) (37)
- Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. (1997) (37)
- CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. (2007) (37)
- Gremlin1 is required for skeletal development and postnatal skeletal homeostasis (2012) (36)
- Invited review of a workshop: anabolic hormones in bone: basic research and therapeutic potential. (1996) (36)
- Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. (1998) (36)
- Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. (1999) (36)
- Canonical Notch activation in osteocytes causes osteopetrosis. (2016) (35)
- Growth factor regulation of insulin‐like growth factor binding protein‐6 expression in osteoblasts (1997) (35)
- MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment. (2019) (33)
- Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells. (1996) (33)
- Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts* *This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundação Coordenação de Aperfeiçoa mento de Pessoal de Nível Superior (CAPES), Uni (1999) (33)
- Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture. (2014) (33)
- Noggin arrests stromal cell differentiation in vitro. (2003) (32)
- Interleukin 6 mediates selected effects of Notch in chondrocytes. (2013) (32)
- Cortisol represses insulin-like growth factor II receptor transcription in skeletal cell cultures. (1995) (32)
- Signals that determine the fate of osteoblastic cells. (2005) (32)
- Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation. (2010) (32)
- Platelet‐derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex (2000) (32)
- Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes. (2013) (31)
- Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations (2016) (31)
- 1,25-Dihydroxyvitamin D3 effects on collagen and DNA synthesis in periosteum and periosteum-free calvaria. (1985) (31)
- Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming. (1978) (31)
- Retinoic acid regulates the expression of insulin‐like growth factors I and II in osteoblasts (1997) (31)
- Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. (2012) (31)
- A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. (2010) (30)
- Nuclear Factor of Activated T-cells (NFAT)c2 Inhibits Notch Receptor Signaling in Osteoblasts* (2012) (29)
- Loss of Gremlin Delays Primordial Follicle Assembly but Does Not Affect Female Fertility in Mice1 (2011) (29)
- The Metastasis-Associated Metalloproteinase Stromelysin-3 Is Induced by Transforming Growth Factor-β in Osteoblasts and Fibroblasts. (2001) (29)
- Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes. (2017) (29)
- The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome (2008) (29)
- Differential effects of warfarin on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix Gla protein in vitro (1994) (28)
- Effects of transforming growth factors on bone cells. (1989) (28)
- Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. (2010) (28)
- Notch and the regulation of osteoclast differentiation and function. (2020) (28)
- An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice (2017) (27)
- Effects of glucocorticoids on the skeleton. (2002) (27)
- Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. (2015) (26)
- Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts. (1999) (26)
- Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro. (2005) (26)
- Editorial: Inhibitory Actions of Glucocorticoids on Skeletal Growth. Is Local Insulin-Like Growth Factor I to Blame? (1998) (26)
- ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of calcium metabolic disorders and osteoporosis (2020) (26)
- Glucocorticoid-induced osteoporosis and parathyroid hormone. (2010) (25)
- Effect of partially purified bone morphogenetic protein on DNA synthesis and cell replication in calvarial and fibroblast cultures. (1985) (25)
- 11β‐Hydroxysteroid Dehydrogenase, an Amplifier of Glucocorticoid Action in Osteoblasts (2002) (25)
- Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro. (2004) (25)
- Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms (2000) (25)
- The lateral meningocele syndrome mutation causes marked osteopenia in mice (2018) (24)
- Insulin-like growth factors and their role in osteoporosis (1996) (24)
- The generation of sulfation factor activity by proteolytic modification of growth hormone. (1980) (24)
- Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP‐2 (2008) (24)
- Dual Regulation of Stromelysin-3 by Fibroblast Growth Factor-2 in Murine Osteoblasts* (1998) (23)
- Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome (2017) (23)
- Role of the Ram Domain and Ankyrin Repeats on Notch Signaling and Activity in Cells of Osteoblastic Lineage (2006) (23)
- Skeletal actions of insulin-like growth factors (2006) (23)
- Novel treatments for osteoporosis. (2000) (23)
- Bone morphogenetic protein-2 inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures. (1995) (22)
- Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders. (2017) (22)
- Factors influencing bone formation in organ culture. (1976) (21)
- Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. (2006) (21)
- The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts. (2001) (21)
- Scanning electron microscopy and gel electrophoresis of vascularized periosteal autografts. (1989) (20)
- Isolation of a nontransforming bone-derived growth factor from medium conditioned by fetal rat calvariae. (1986) (20)
- Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. (1998) (20)
- Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts. (1999) (20)
- Nephroblastoma Overexpressed (Nov) Is a Novel Bone Morphogenetic Protein Antagonist (2007) (19)
- Effect of sex steroids on bone collagen synthesis in vitro (1978) (19)
- Effects of desamino-(1-3)-insulin-like growth factor I on bone cell function in rat calvarial cultures. (1991) (19)
- Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts. (1999) (18)
- Glucocorticoids inhibit notch target gene expression in osteoblasts (2018) (18)
- Growth hormone, skeletal growth factors and osteoporosis. (1995) (18)
- Expression and growth factor regulation of platelet-derived growth factor B transcripts in primary osteoblast cell cultures. (1996) (18)
- Insulin-like growth factor II promoter expression in cultured rodent osteoblasts and adult rat bone. (1998) (17)
- Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts. (1999) (17)
- Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis. (2018) (17)
- Isolation of growth factors from adult bovine bone (1988) (16)
- Inhibitory actions of glucocorticoids on skeletal growth. Is local insulin-like growth factor I to blame? (1998) (16)
- Hairy and Enhancer of Split-related with YRPW Motif (HEY)2 Regulates Bone Remodeling in Mice* (2013) (16)
- An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice (2020) (16)
- Systemic and local factors and the maintenance of bone quality (2005) (16)
- Growth factors and the skeletal system (1989) (16)
- BMD Regulation on Mouse Distal Chromosome 1, Candidate Genes, and Response to Ovariectomy or Dietary Fat (2010) (16)
- Selective stimulation of sulfated glycosaminoglycan synthesis by multiplication-stimulating activity, cartilage-derived factor and bone-derived growth factor. Comparison of their actions on cultured chondrocytes with those of fibroblast growth factor and Rhodamine fibrosarcoma-derived growth factor. (1982) (15)
- Effect of cortisol on periosteal and nonperiosteal collagen and DNA synthesis in cultured rat calvariae (1984) (15)
- Overexpression of IGF-Binding Protein 5 Alters Mineral and Matrix Properties in Mouse Femora: An Infrared Imaging Study (2005) (15)
- Nemo‐like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling (2012) (15)
- Deficiency of Sef Is Associated With Increased Postnatal Cortical Bone Mass by Regulating Runx2 Activity (2014) (15)
- Treatment of glucocorticoid-induced osteoporosis (2009) (15)
- Growth factors and bone (1997) (15)
- Transforming growth factor-beta increases interleukin-6 transcripts in osteoblasts. (2000) (15)
- Effect of bone-derived growth factor on DNA, RNA, and proteoglycan synthesis in cultures of rabbit costal chondrocytes. (1982) (15)
- Transgenic Overexpression of Gremlin Results in Developmental Defects in Enamel and Dentin in Mice (2008) (14)
- Bone morphogenetic protein‐2 suppresses collagenase‐3 promoter activity in osteoblasts through a runt domain factor 2 binding site (2005) (14)
- Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. (2014) (13)
- Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis (2022) (13)
- Hormonal regulation of mineral metabolism. (1977) (13)
- Activation Of Nfatc2 in osteoblasts causes osteopenia (2015) (12)
- Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome (2020) (12)
- Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice (2015) (10)
- Transcriptional regulation of collagenase‐3 by interleukin‐1 alpha in osteoblasts (2003) (10)
- The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone. (2018) (10)
- Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo (2018) (10)
- The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α (2019) (10)
- Effects of Sex and Notch Signaling on the Osteocyte Cell Pool (2017) (10)
- Prevention and treatment of glucocorticoid-induced osteoporosis. (2008) (10)
- Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts. (1998) (9)
- The cellular and molecular basis of glucocorticoid actions in bone. (2002) (9)
- Transgenic mice expressing selected insulin-like growth factor-binding protein-5 fragments do not exhibit enhanced bone formation. (2004) (9)
- NOVEL ANABOLIC TREATMENTS FOR OSTEOPOROSIS (2017) (9)
- Gene delivery by retroviruses. (2008) (9)
- Platelet-Derived Growth Factor and the Skeleton (2008) (9)
- Growth Factors, Bone Metabolism, and Metabolic Bone Diseases (1996) (8)
- Glucocorticoid-induced osteoporosis (2000) (8)
- Hairy and Enhancer of Split‐Related With YRPW Motif‐Like (HeyL) Is Dispensable for Bone Remodeling in Mice (2017) (7)
- Factors That Regulate Bone Formation (1993) (7)
- Nemo‐Like Kinase Regulates Postnatal Skeletal Homeostasis (2014) (7)
- Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis (2020) (7)
- Notch signaling and bone (2011) (6)
- Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism (2019) (6)
- Dynamic bone morphometry and studies on the effects of serum on ben meta lism in vitro in a case of pycnodysostosis (1980) (6)
- CHAPTER 11 – Parathyroid Hormone: Anabolic and Catabolic Effects on Bone and Interactions with Growth Factors (2001) (6)
- Nephroblastoma overexpressed (Nov) induces gremlin in ST‐2 stromal cell lines by post‐transcriptional mechanisms (2011) (5)
- The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. (2011) (5)
- Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts* *This work was supported by NIAMSD Grant AR-21707. (2000) (5)
- Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis. (2018) (5)
- Notch and its ligands (2020) (4)
- Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T‐cells (NFAT) in cells of the osteoblastic lineage (2010) (4)
- Osteopenia and decreased bone formation in osteonectin-deficient mice. (2000) (4)
- CLOSURE OF THORACOTOMY WITH RESORBABLE PLATES VERSUS CLASSIC INTERCOSTAL SUTURES (2009) (4)
- Effect of multiplication-stimulating activity on DNA and protein synthesis in cultured fetal rat calvaria (1979) (4)
- The Dmp1‐SOST Transgene Interacts With and Downregulates the Dmp1‐Cre Transgene and the RosaNotch Allele (2016) (3)
- Erratum: Transforming growth factor β1 inhibits collagenase 3 expression by transcriptional and post‐transcriptional mechanisms in osteoblast cultures. J. Cell. Physiol. 170:145–152. (1997) (3)
- Role of Notch signaling in osteoblast differentiation and bone remodeling (2009) (3)
- The Skeleton of Lateral Meningocele Syndrome (2021) (3)
- Role of Insulin-Like Growth Factor I And II on Skeletal Remodeling (1989) (3)
- Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling (2021) (3)
- CHAPTER 29 – Metabolic Bone Disease (2011) (2)
- Chapter 46 – Platelet-Derived Growth Factor and the Skeleton (2002) (2)
- Effect of cartilage-derived factor on DNA and protein synthesis in cultured rat calvariae (2006) (2)
- The heparin-binding domain of IGFBP-2 has IGF binding-independent biologic activity in the growing skeleton (2011) (2)
- Local bone growth factors (1984) (1)
- Growth Factors and the Skeleton (1998) (1)
- Analysis of hydroxyproline by high performance liquid chromatography and its application to collagen turnover studies in bone cultures (1989) (1)
- Hypercalcemia: diagnosis and therapy. (1977) (1)
- Use of antisense oligonucleotides to target Notch3 in skeletal cells (2022) (1)
- Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice. (2022) (1)
- Modern concepts of calcium homeostasis. (1976) (1)
- In vitro and in vivo actions of growth factors on the skeleton (1996) (1)
- Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function (2021) (1)
- ACTION OF GROWTH FACTORS ON CHONDROCYTES: DISCOVERY OF LOCAL SOMATOMEDINS IN FETAL BOVINE CARTILAGE (1983) (1)
- Role of nuclear factor of activated T cells in chondrogenesis osteogenesis and osteochondroma formation (2022) (1)
- Role of Notch Signaling in Bone Remodeling and Skeletal Diseases (2020) (1)
- The role of insulin-like growth factors in bone remodelling (1992) (1)
- 1 1 2 3 CANONICAL NOTCH ACTIVATION IN OSTEOCYTES CAUSES OSTEOPETROSIS 4 5 6 7 8 (2015) (0)
- A mutant mouse model of Hajdu-Cheney syndrome (2016) (0)
- List of contributors (2021) (0)
- Skeletal Effects of Glucocorticoids: Basic and Clinical Aspects (2005) (0)
- Systemic and local factors and the maintenance of bone quality. Discussion (1993) (0)
- Growing Skeleton Binding-independent Biologic Activity in Has Insulin-like Growth Factor The Heparin-binding Domain of IGFBP-2 Cell Biology : (2011) (0)
- PRECISE EXCISION OF LUNG NODULES WITH 1318 NM LASER PLUS PLEURAL SEALANT (2009) (0)
- List of Reviewers 2002–2003 (2003) (0)
- Cellular Mechanisms of Glucocorticoid Action in Bone (2014) (0)
- Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway (2019) (0)
- Retinoic acid induces the transcription of insulin-like growth factor binding protein-6 (IGFBP-6) in osteoblast cells (1995) (0)
- RAP-661 treatment, an ALK3 (BMPRIA) antagonist, decreases rankl and regulates osteoclastogenesis (2011) (0)
- Notch Signaling in Skeletal Diseases (2020) (0)
- Calcium and the kidney: renal osteodystrophy and renal calculi. (1977) (0)
- Murine Bone Exhibits Temporal and Dosage Response to Metabolic Acidosis (2022) (0)
- Serum Cortisoland 11-Deoxycortisolby LiquidChromatography: ClinicalStudiesand Comparisonwith Radioimmunoassay (2004) (0)
- New treatments in osteoporosis (2001) (0)
- Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. (1998) (0)
- Induced pluripotent stem cell technology in bone biology. (2023) (0)
- Paget's disease of bone: recent advances in therapy. (1977) (0)
- Resection of Lung Nodules With 1318 Nm LASER Precise Excision plus Pleural Sealant (2010) (0)
- Remembering Dr John D Termine (2021) (0)
- Determinant of Bone Mass HES1 (Hairy and Enhancer of Split 1) Is a Developmental Biology (2014) (0)
- Relief Of Postoperative Pain Syndrome By closing Thoracotomy With Resorbable Plates Versus Classic Intercostal Sutures (2010) (0)
- CHAPTER 19 – Skeletal Growth Factors (2008) (0)
- and Paracrine Secretion of Connective Tissue Growth Factor (2014) (0)
- Abstracts of the 6th International Congress on Glucocorticoid-induced Osteoporosis (GIO). October 8-10, 2009. Siena, Italy. (2009) (0)
- Osteopenia: osteoporosis, osteomalacia and other forms of decreased mineralized bone mass. (1976) (0)
- Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts. (1999) (0)
- Establishment of the professional practice committee (1995) (0)
- Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders (2011) (0)
- Novel signals determining skeletal cell fate and function (2016) (0)
- List of Contributors (2020) (0)
- Preliminary Pages / Contents / Foreword (2002) (0)
- SYMPATHECTOMY FOR HYPERHIDROSIS THROUGH VIDEOTHORACOSCOPY WITH TRACHEAL INTUBATION AND SEATING POSITION OF THE PATIENT (2009) (0)
- Correction to: Notch in skeletal physiology and disease (2018) (0)
- AP-1 and multiple response element binding sites are necessary for the stimulation of interleukin-6 by platelet-derived growth factor in osteoblasts (1995) (0)
- Glucocorticoid Regulation ofTransforming GrowthFactor 31 Activity andBinding inOsteoblast-Enric hed Cultures fromFetal RatBone (1991) (0)
- Regulates Cancellous and Cortical Bone Notch Signaling in Osteocytes Differentially Molecular Bases of Disease : (2013) (0)
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