Ernst Hafen
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Biology
Ernst Hafen's Degrees
- PhD Genetics University of Zurich
- Masters Biology University of Zurich
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(Suggest an Edit or Addition)Ernst Hafen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein (2001) (1377)
- Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. (2004) (1307)
- An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control (2001) (1131)
- Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. (2003) (1024)
- A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes (1984) (971)
- Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4 (1999) (823)
- Drosophila S6 kinase: a regulator of cell size. (1999) (768)
- Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. (2005) (759)
- Nutrient-Dependent Expression of Insulin-like Peptides from Neuroendocrine Cells in the CNS Contributes to Growth Regulation in Drosophila (2002) (703)
- Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells (1999) (568)
- Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. (2003) (553)
- The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling (2003) (552)
- Rheb is an essential regulator of S6K in controlling cell growth in Drosophila (2003) (548)
- A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos (1993) (526)
- The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. (1996) (509)
- Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body (2004) (443)
- Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. (2000) (440)
- A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways (1994) (413)
- Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain. (1987) (376)
- The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway (1994) (372)
- Drosophila Egg-Laying Site Selection as a System to Study Simple Decision-Making Processes (2008) (340)
- PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. (1999) (330)
- The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. (1996) (329)
- Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development (1984) (325)
- The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. (2004) (318)
- Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry (2004) (314)
- Raf functions downstream of Rasl in the Sevenless signal transduction pathway (1992) (313)
- Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus (1996) (310)
- The WW domain protein Kibra acts upstream of Hippo in Drosophila. (2010) (308)
- An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex (1983) (301)
- Dietary Restriction in Long-Lived Dwarf Flies (2002) (299)
- Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila (1987) (270)
- A high-quality catalog of the Drosophila melanogaster proteome (2007) (268)
- Will Democracy Survive Big Data and Artificial Intelligence? (2017) (266)
- Genetic control of cell size. (2000) (256)
- Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye (1991) (239)
- Rescue of the Drosophila phototransduction mutation trp by germline transformation. (1985) (227)
- The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource (2007) (226)
- The DrosDel Collection (2004) (226)
- Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila (1984) (221)
- Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance (2008) (220)
- The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. (1994) (219)
- Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB (2002) (213)
- Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. (1997) (211)
- The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development. (1994) (202)
- DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila (1996) (198)
- dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 (2002) (197)
- Model for the regulation of size in the wing imaginal disc of Drosophila (2007) (193)
- A Novel, Evolutionarily Conserved Protein Phosphatase Complex Involved in Cisplatin Sensitivity*S (2005) (193)
- Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye. (1997) (193)
- Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs (2008) (188)
- The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. (1996) (184)
- PDK1 regulates growth through Akt and S6K in Drosophila (2001) (177)
- The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. (2002) (171)
- Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration. (1994) (166)
- Spatial distribution of Antennapedia transcripts during Drosophila development. (1983) (156)
- Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster (2009) (155)
- Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain (1988) (154)
- Common and distinct roles of DFos and DJun during Drosophila development. (1997) (154)
- The heat shock protein 83 (Hsp83) is required for Raf‐mediated signalling in Drosophila (1997) (142)
- The paired box gene pox neuro: A determiant of poly-innervated sense organs in Drosophila (1992) (135)
- Knockout of ‘metal‐responsive transcription factor’ MTF‐1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis (2003) (135)
- Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis (2011) (133)
- Response to Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body" (2005) (132)
- Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity. (2001) (123)
- Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila (1984) (122)
- Exploring the effects of mechanical feedback on epithelial topology (2010) (120)
- Biochemical membrane lipidomics during Drosophila development. (2013) (117)
- Ras--a versatile cellular switch. (1998) (116)
- Genetic control of size in Drosophila. (2000) (115)
- Control of drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the raf kinase (1995) (114)
- Mutations Modulating Raf signaling in Drosophila eye development. (1996) (105)
- Substrate-dependent control of MAPK phosphorylation in vivo (2011) (102)
- Genetics of signal transduction in invertebrates. (1994) (96)
- Health Data Cooperatives – Citizen Empowerment (2014) (96)
- The spatial and temporal expression pattern of sevenless is exclusively controlled by gene‐internal elements. (1989) (91)
- The Drosophila SH2B Family Adaptor Lnk Acts in Parallel to Chico in the Insulin Signaling Pathway (2009) (87)
- Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk (2010) (84)
- Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough. (1990) (82)
- Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor. (1992) (78)
- The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4‐driven growth (2005) (76)
- Cancer, type 2 diabetes, and ageing: news from flies and worms. (2004) (74)
- Ubiquitous expression of sevenless: position-dependent specification of cell fate. (1989) (73)
- Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. (1995) (69)
- How Are the Sizes of Cells, Organs, and Bodies Controlled? (2003) (64)
- Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome (2011) (63)
- A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila (2009) (61)
- Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR. (2004) (59)
- The Hemolymph Proteome of Fed and Starved Drosophila Larvae (2013) (58)
- Experiences of Early Users of Direct-to-Consumer Genomics in Switzerland: An Exploratory Study (2012) (58)
- Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo (1997) (55)
- The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain (2013) (54)
- Diet-Dependent Effects of the Drosophila Mnk1/Mnk2 Homolog Lk6 on Growth via eIF4E (2005) (54)
- Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. (2006) (53)
- Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. (2001) (53)
- Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster (2015) (52)
- Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster. (2001) (52)
- Use of anionic denaturing detergents to purify insoluble proteins after overexpression (2012) (51)
- Dynamics of Drosophila eye development and temporal requirements of sevenless expression. (1989) (50)
- Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells (2006) (50)
- Specification of cell fate in the developing eye of Drosophila (1991) (48)
- The Drosophila melanogaster PeptideAtlas facilitates the use of peptide data for improved fly proteomics and genome annotation (2009) (46)
- Kinases and Phosphatases--A Marriage Is Consummated (1998) (40)
- The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER (2003) (39)
- Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster (2016) (39)
- Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis (1998) (39)
- MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress (2011) (38)
- The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis (2012) (38)
- TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules (2015) (36)
- Diagnostic of students' misconceptions using the Biological Concepts Instrument (BCI): A method for conducting an educational needs assessment (2017) (35)
- The RNA-binding Proteins FMR1, Rasputin and Caprin Act Together with the UBA Protein Lingerer to Restrict Tissue Growth in Drosophila melanogaster (2013) (35)
- Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues (2013) (35)
- Playing a Part in Research? University Students' Attitudes to Direct-To-Consumer Genomics (2014) (33)
- The dominant mutation Glazed is a gain-of-function allele of wingless that, similar to loss of APC, interferes with normal eye development. (1999) (33)
- Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate. (1988) (31)
- Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways (2004) (31)
- Dietary Restriction and Life-Span (2002) (30)
- Susi, a negative regulator of Drosophila PI3-kinase. (2005) (30)
- An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. (2004) (29)
- High-resolution SNP mapping by denaturing HPLC (2002) (29)
- Democratizing Health Research Through Data Cooperatives (2018) (28)
- A universal method for automated gene mapping (2005) (28)
- Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila (2010) (27)
- Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. (2002) (27)
- Biochemical Characterization of RolledSem, an Activated Form of Drosophila Mitogen-activated Protein Kinase* (1996) (27)
- Towards Long Term Cultivation of Drosophila Wing Imaginal Discs In Vitro (2014) (27)
- The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction (2013) (26)
- Control of Growth and Differentiation byDrosophila RasGAP, a Homolog of p120 Ras–GTPase-Activating Protein (1999) (26)
- Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions. (2013) (26)
- The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival (2008) (25)
- Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth (2008) (24)
- Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila. (1993) (24)
- dS 6 K-regulated cell growth is dPKB / dPI ( 3 ) K-independent , but requires dPDK 1 (2006) (24)
- The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila (2010) (22)
- Drosophila cbl Is Essential for Control of Cell Death and Cell Differentiation during Eye Development (2008) (20)
- 6 Growth Regulation by Insulin and TOR Signaling in Drosophila (2004) (20)
- A Proteome Catalog of Drosophila melanogaster: An Essential Resource for Targeted Quantitative Proteomics (2007) (18)
- SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development. (2009) (17)
- Attitudes towards personal genomics among older Swiss adults: An exploratory study (2016) (16)
- The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye (2006) (15)
- Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila (1994) (14)
- Year : 2003 Insulin activation of Rheb , a mediator of mTOR / S 6 K / 4 EBP signaling , is inhibited by TSC 1 and 2 (2006) (13)
- Genetic dissection of cell fate specification in the developing eye ofDrosophila (1996) (13)
- Patterning by cell recruitment in the Drosophila eye. (1991) (13)
- Genetic analysis of the sevenless signal transduction pathway of Drosophila. (1993) (12)
- Personal Data Cooperatives – A New Data Governance Framework for Data Donations and Precision Health (2019) (11)
- A reverse genetic screen in Drosophila using a deletion-inducing mutagen (2004) (10)
- The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain (2013) (9)
- Lilliputian : an AF 4 / FMR 2-related protein that controls cell identity and cell growth (8)
- New indicators and indexes for benchmarking university–industry–government innovation in medical and life science clusters: results from the European FP7 Regions of Knowledge HealthTIES project (2019) (8)
- Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics). (2014) (8)
- Towards Rawlsian ‘property-owning democracy’ through personal data platform cooperatives (2020) (7)
- Receptor tyrosine kinases mediate cell-cell interactions during Drosophila development. (1990) (6)
- The FlyCatwalk: A High-Throughput Feature-Based Sorting System for Artificial Selection in Drosophila (2015) (6)
- Multi-Functional Regulation of 4E-BP Gene Expression by the Ccr4-Not Complex (2015) (6)
- Diet-Dependent Effects of the Drosophila Mnk1/Mnk2 Homolog Lk6 on Growth via eIF4E (2005) (5)
- Year : 2003 Rheb is an essential regulator of S 6 K in controlling cell growth in Drosophila (2006) (5)
- Sex‐dependent and sex‐independent regulatory systems of size variation in natural populations (2019) (4)
- Debunking key and lock biology: Exploring the prevalence and persistence of students’ misconceptions on the nature and flexibility of molecular interactions (2016) (4)
- Using smartphone accelerometer data to obtain scientific mechanical-biological descriptors of resistance exercise training (2020) (4)
- Mechanisms of positional signalling in the developing eye of Drosophila studied by ectopic expression of sevenless and rough (1990) (4)
- Faculty Opinions recommendation of Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye. (2002) (3)
- Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility. (2021) (3)
- IMIA working group on health record banking - How complex systems can cooperate towards having individual's consolidated data (2016) (2)
- Dietary restriction and life-span - Response (2002) (2)
- Role of receptor tyrosine kinases during Drosophila development. (1990) (2)
- Drosophila – a Model System for Targets and Lead Identification in Cancer and Metabolic Disorders (2005) (2)
- Pushing single-gene genetic analysis up a Notch. (2009) (2)
- Year : 2006 Csk differentially regulates Src 64 during distinct morphological events in Drosophila germ cells (2006) (1)
- Author response: Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues (2013) (1)
- Year : 2004 The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S 6 K activity upstream of TSC in Drosophila (2006) (1)
- Genetic analysis of the sevenless signal transduction pathway of Drosophila. (1993) (1)
- The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction (2013) (1)
- Governance and IT Architecture (2019) (1)
- Year : 2003 The Drosophila dual-specificity ERK phosphatase DMKP 3 cooperates with the ERK tyrosine phosphatase PTP (2006) (0)
- Who will win the fight for our data (2019) (0)
- Democratizing Health Research Through Data Cooperatives (2018) (0)
- TECHNICAL COMMENT ABSTRACTS (2005) (0)
- The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis (2012) (0)
- New indicators and indexes for benchmarking university-industry-government innovation in medical and life science clusters: Results from European FP7 Regions of Knowledge project HealthTIES (2019) (0)
- Genetic screens in Drosophila have come a long way since the pioneering work of Nüsslein-Volhard (2009) (0)
- Connecting up the pathways in Drosophila development. (1997) (0)
- FLYCAT; Towards a Drosophila Proteome Database Differential Proteomic Analysis of the Human Pathogen Trichomonas vaginalis (2005) (0)
- Technology – Two of Three Pillars of Precision Medicine and Personalized Health (2017) (0)
- In vitro cultivation of imaginal wing discs of drosophila melanogaster (2009) (0)
- in cisplatin sensitivity (2005) (0)
- The Citizen – The Third Pillar in Precision Medicine and Personalized Health (2014) (0)
- Analysis of novel alleles of brother of tout‐velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovoD chromosome (2016) (0)
- The Genetics Company, Inc. - A newly founded Swiss Biotech Company (2000) (0)
- Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility (2021) (0)
- Mapping the protein-protein interactions of Drosophila melanogaster (2009) (0)
- The CdiTESK1 kinase is required for sevenless signaling and photoreceptor cell shape in the Drosophila eye (2006) (0)
- Specification of cell fate in the developing eye of Drosophila. (1991) (0)
- Contents Vol. 15, 2012 (2012) (0)
- Wing commanders (1997) (0)
- [Genome analysis - what does the future hold, what is science fiction? Interview by Prof. Dr. med. Johann Steurer]. (2012) (0)
- Understanding Randomness on a Molecular Level: A Diagnostic Tool. (2023) (0)
- FLP detection of InDels of various sizes in homozygotes and heterozygotes (2011) (0)
- Algorithmic extraction of smartphone accelerometer-derived mechano-biological descriptors of resistance exercise is robust to changes in intensity and velocity (2021) (0)
- Editorial board members (2007) (0)
- Results and discussion Removal of endogenous MAPK substrates reduces MAPK phosphorylation in vivo (2013) (0)
- Bunched, the homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth-4 (2011) (0)
- Example of peptides confirming a case of alternative splicing of the lamin A/C gene (LMNA) (2011) (0)
- Growth-regulating gene (2003) (0)
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What Schools Are Affiliated With Ernst Hafen?
Ernst Hafen is affiliated with the following schools:
