Erwin Sigel
#164,769
Most Influential Person Now
Researcher
Erwin Sigel's AcademicInfluence.com Rankings
Erwin Sigelbiology Degrees
Biology
#13281
World Rank
#16821
Historical Rank
Molecular Biology
#2228
World Rank
#2262
Historical Rank
Biochemistry
#2314
World Rank
#2462
Historical Rank
Download Badge
Chemistry Biology
Erwin Sigel's Degrees
- PhD Biochemistry University of Vienna
- Masters Chemistry University of Vienna
- Bachelors Chemistry University of Vienna
Why Is Erwin Sigel Influential?
(Suggest an Edit or Addition)Erwin Sigel's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The effect of subunit composition of rat brain GABAA receptors on channel function (1990) (589)
- The benzodiazepine binding site of GABAA receptors. (1997) (527)
- Structure, Function, and Modulation of GABAA Receptors* (2012) (491)
- The regulation of intracellular calcium. (1976) (404)
- A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. (1983) (331)
- Forced subunit assembly in α1β2γ2 GABAA receptors: insight into the absolute arrangement (2002) (241)
- Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. (2002) (231)
- Subunit Arrangement of γ-Aminobutyric Acid Type A Receptors* (2001) (217)
- Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. (1992) (217)
- Mapping of the benzodiazepine recognition site on GABA(A) receptors. (2002) (208)
- The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects (2004) (202)
- A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions. (1984) (187)
- Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels. (1988) (181)
- The purified Ca2+ pump of human erythrocyte membranes catalyzes an electroneutral Ca2+-H+ exchange in reconstituted liposomal systems. (1982) (178)
- The Benzodiazepine Binding Sites of GABAA Receptors. (2018) (154)
- The major central endocannabinoid directly acts at GABAA receptors (2011) (154)
- ReviewThe benzodiazepine binding site of GABAA receptors (1997) (150)
- Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor (1990) (149)
- Properties of single sodium channels translated by Xenopus oocytes after injection with messenger ribonucleic acid. (1987) (133)
- Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites. (1992) (131)
- Individual Properties of the Two Functional Agonist Sites in GABAA Receptors (2003) (130)
- A Kinetic Study of the Energy‐Linked Influx of Ca2+ into Heart Mitochondria (1976) (127)
- Functional expression and sites of gene transcription of a novel α subunit of the GABAA receptor in rat brain (1990) (121)
- Azo-propofols: photochromic potentiators of GABA(A) receptors. (2012) (120)
- The relative amount of cRNA coding for γ2 subunits affects stimulation by benzodiazepines in GABAA receptors expressed in Xenopus oocytes (2002) (117)
- Recombinant GABAA receptor function and ethanol (1993) (111)
- Subtle Changes in Residue 77 of the γ Subunit of α1β2γ2 GABAA Receptors Drastically Alter the Affinity for Ligands of the Benzodiazepine Binding Site* (1997) (109)
- Positioning of the α-subunit isoforms confers a functional signature to γ-aminobutyric acid type A receptors (2004) (109)
- Activation of protein kinase C results in down‐modulation of different recombinant GABAA‐channels (1991) (108)
- A closer look at the high affinity benzodiazepine binding site on GABAA receptors. (2011) (103)
- A GABAA receptor of defined subunit composition and positioning: Concatenation of five subunits (2006) (98)
- A simple system for the measurement of ion activities with solvent polymeric membrane electrodes. (1979) (98)
- Allosteric modulation by benzodiazepine receptor ligands of the GABAA receptor channel expressed in Xenopus oocytes (1988) (92)
- A point mutation in the γ2 subunit of γ-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity (1997) (91)
- The rat β1 ‐subunit of the GABAA receptor forms a picrotoxin‐sensitive anion channel open in the absence of GABA (1989) (86)
- The γ3‐subunit of the GABAA‐receptor confers sensitivity to benzodiazepine receptor ligands (1991) (84)
- Residues at Positions 206 and 209 of the α1 Subunit of γ-Aminobutyric AcidA Receptors Influence Affinities for Benzodiazepine Binding Site Ligands (1997) (81)
- Unanticipated Structural and Functional Properties of δ-Subunit-containing GABAA Receptors* (2009) (78)
- Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site. (1996) (77)
- Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes. (1987) (77)
- The proton pump of cytochrome c oxidase and its stoichiometry. (1978) (74)
- Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor γ2 subunit (2004) (73)
- Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement. (2002) (72)
- On the Benzodiazepine Binding Pocket in GABAA Receptors* (2004) (71)
- The Xenopus oocyte: system for the study of functional expression and modulation of proteins. (2005) (70)
- Functional characterization of the new human GABAA receptor mutation β3(R192H) (2002) (69)
- GABAA-receptor subtypes (1996) (63)
- Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. (2003) (58)
- Techniques: Use of concatenated subunits for the study of ligand-gated ion channels. (2004) (57)
- Monepantel Allosterically Activates DEG-3/DES-2 Channels of the Gastrointestinal Nematode Haemonchus contortus (2010) (57)
- The benzodiazepine binding pocket of recombinant alpha1beta2gamma2 gamma-aminobutyric acidA receptors: relative orientation of ligands and amino acid side chains. (1998) (56)
- Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital (2016) (56)
- Use ofXenopus oocytes for the functional expression of plasma membrane proteins (1990) (55)
- Rotation of cytochrome oxidase in phospholipid vesicles. Investigations of interactions between cytochrome oxidases and between cytochrome oxidase and cytochrome bc1 complex. (1981) (54)
- Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs (2008) (51)
- Functional modulation of ligand-gated GABAA and NMDA receptor channels by phosphorylation. (1995) (51)
- Quantitative analysis of the proton and charge stoichiometry of cytochrome c oxidase from beef heart reconstituted into phospholipid vesicles. (1980) (50)
- Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors. (2004) (49)
- Structure of α6β3δ GABAA receptors and their lack of ethanol sensitivity (2009) (49)
- Isolation of a GABA receptor from bovine brain using a benzodiazepine affinity column (1982) (47)
- Proteins Associated with α1‐Subunit‐Containing GABAA Receptors from Bovine Brain (1997) (45)
- Impact of subunit positioning on GABAA receptor function. (2006) (44)
- Cytochrome oxidase rotates in the inner membrane of intact mitochondria and submitochondrial particles. (1980) (44)
- Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites. (1994) (43)
- Anticipating antiport in P-type ATPases. (2008) (42)
- A point mutation in the gamma2 subunit of gamma-aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. (1997) (41)
- Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). (2002) (40)
- Electrophysiological Evidence for the Coexistence of α1 and α6 Subunits in a Single Functional GABAA Receptor (2000) (40)
- myo-Inositol Uptake Is Essential for Bulk Inositol Phospholipid but Not Glycosylphosphatidylinositol Synthesis in Trypanosoma brucei* (2012) (38)
- Subtle changes in residue 77 of the gamma subunit of alpha1beta2gamma2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site. (1997) (38)
- acr-23 Encodes a Monepantel-Sensitive Channel in Caenorhabditis elegans (2013) (37)
- On high‐ and low‐affinity agonist sites in GABAA receptors (2003) (36)
- A Venom-derived Neurotoxin, CsTx-1, from the Spider Cupiennius salei Exhibits Cytolytic Activities* (2012) (35)
- The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABAA receptors (2012) (35)
- Two Novel Residues in M2 of the γ-Aminobutyric Acid Type A Receptor Affecting Gating by GABA and Picrotoxin Affinity* (2001) (34)
- The promiscuous role of the epsilon subunit in GABAA receptor biogenesis (2008) (34)
- Membrane Biochemistry (1979) (34)
- Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators. (2007) (33)
- Amino acid residue 200 on the alpha1 subunit of GABA(A) receptors affects the interaction with selected benzodiazepine binding site ligands. (1998) (32)
- Role of the Conserved Lysine Residue in the Middle of the Predicted Extracellular Loop Between M2 and M3 in the GABAA Receptor (1999) (32)
- Residues at positions 206 and 209 of the alpha1 subunit of gamma-aminobutyric AcidA receptors influence affinities for benzodiazepine binding site ligands. (1997) (32)
- The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes. (1989) (30)
- Benzodiazepines Affect Channel Opening of GABAA Receptors Induced by Either Agonist Binding Site (2005) (30)
- Monepantel Irreversibly Binds to and Opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 Receptors (2015) (29)
- The polarized distribution of poly(A+)-mRNA-induced functional ion channels in the Xenopus oocyte plasma membrane is prevented by anticytoskeletal drugs (1991) (29)
- Interaction between GABAA Receptor β Subunits and the Multifunctional Protein gC1q-R* (2001) (28)
- Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls. (2009) (28)
- Forced Subunit Assembly in α1β2γ2 GABAAReceptors (2002) (28)
- The charge stoichiometry of cytochrome c oxidase in the reconstituted system. (1979) (27)
- Molecular analysis of the site for 2‐arachidonylglycerol (2‐AG) on the β2 subunit of GABAA receptors (2013) (27)
- Inhibition of the purified and reconstituted calcium pump of erythrocytes by μM levels of dids and nap‐taurine (1982) (26)
- Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors* (2016) (24)
- Mitochondria and the regulation of cell calcium (1975) (24)
- α subunits in GABAA receptors are dispensable for GABA and diazepam action (2017) (24)
- Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors (2015) (22)
- Subunit Stoichiometry of Oligomeric Membrane Proteins: GABAA Receptors Isolated by Selective Immunoprecipitation from the Cell Surface (1996) (22)
- THE REGULATION OF INTRACELLULAR CALCIUM (1976) (22)
- Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors. (2014) (21)
- Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptors. (2010) (21)
- The Benzodiazepine Recognition Site on GABAA Receptors (2005) (21)
- N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole. (2002) (20)
- The antiepileptic drug AWD 131–138 stimulates different recombinant isoforms of the GABAA receptor through the benzodiazepine binding site (1998) (20)
- Flagellar membranes are rich in raft-forming phospholipids (2015) (19)
- Conformational changes at benzodiazepine binding sites of GABAA receptors detected with a novel technique (2005) (19)
- Two neighboring residues of loop A of the α1 subunit point towards the benzodiazepine binding site of GABAA receptors (2007) (19)
- mRNA-induced expression of the cardiac Na+-Ca2+ exchanger in Xenopus oocytes. (1988) (19)
- Relative positioning of diazepam in the benzodiazepine‐binding‐pocket of GABAA receptors (2009) (19)
- Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening. (2014) (19)
- Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors. (2014) (19)
- Consequence of the presence of two different β subunit isoforms in a GABAA receptor (2005) (18)
- Structure and properties of the brain GABA/benzodiazepine receptor complex. (1984) (18)
- Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site (2015) (18)
- A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes (2015) (18)
- Exon 17 skipping in CLCN1 leads to recessive myotonia congenita (2004) (18)
- Replacement of histidine in position 105 in the α5 subunit by cysteine stimulates zolpidem sensitivity of α5β2γ2 GABAA receptors (2007) (17)
- Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. (2014) (17)
- Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth (2015) (16)
- Highly Potent Modulation of GABAA Receptors by Valerenic Acid Derivatives (2010) (16)
- Novel chloride channel mutations leading to mild myotonia among Chinese (2008) (15)
- 5-[1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4, 5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA(A) receptor with a new mode of action. (2000) (15)
- Diversity of Structure and Function of α1α6β3δ GABAA Receptors (2010) (15)
- Proteins associated with alpha 1-subunit-containing GABAA receptors from bovine brain. (1997) (15)
- A novel positive allosteric modulator of the GABAA receptor: the action of (+)‐ROD188 (2000) (15)
- Molecular mode of action of CGS 9895 at α1β2γ2 GABAA receptors (2016) (15)
- Novel Plant Substances Acting as β Subunit Isoform-Selective Positive Allosteric Modulators of GABAA Receptors (2005) (14)
- Reconstitution of the purified γ-aminobutyric acid-benzodiazepine receptor complex from bovine cerebral cortex into phospholipid vesicles (1985) (14)
- Rotation of Cytochrome Oxidase in Phospholipid Vesicles (1981) (14)
- Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors? (2013) (14)
- Transporters of Trypanosoma brucei—phylogeny, physiology, pharmacology (2018) (13)
- A Novel Serine Kinase with Specificity for β3-Subunits Is Tightly Associated with GABAA Receptors* (1999) (13)
- Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain. (1990) (13)
- Mitochondrial Calcium Transport and the Intracellular Calcium Homeostasis (1977) (13)
- H+-dependent inorganic phosphate uptake in Trypanosoma brucei is influenced by myo-inositol transporter (2017) (12)
- Electrophysiological evidence for the coexistence of alpha1 and alpha6 subunits in a single functional GABA(A) receptor. (2000) (12)
- The purified GABA/benzodiazepine complex: Retention of multiple functions (1984) (12)
- Dual mode of stimulation by the β‐carboline ZK 91085 of recombinant GABAA receptor currents: molecular determinants affecting its action (1999) (12)
- The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. (1991) (12)
- Influence of GABAA Receptor α Subunit Isoforms on the Benzodiazepine Binding Site (2012) (12)
- The purified GABA/benzodiazepine/barbiturate receptor complex: four types of ligand-binding sites, and the interactions between them, are preserved in a single isolated protein complex. (1984) (11)
- Preparation and utilization of an ion-specific calcium minielectrode. (1987) (11)
- Effects of veratridine on single neuronal sodium channels expressed inXenopus oocytes (1987) (11)
- Novel positive allosteric modulators of GABA(A) receptors (2001) (11)
- Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABA(A) receptor. (2000) (11)
- Loreclezole as a simple functional marker for homomeric ρ type GABAC receptors (2000) (10)
- Novel positive allosteric modulators of GABAA receptors with anesthetic activity (2016) (10)
- TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes (2017) (9)
- Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. (2013) (9)
- GABAA-receptor subunits: functional expression and gene localisation. (1990) (8)
- Differential cross talk of ROD compounds with the benzodiazepine binding site. (2001) (8)
- Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor. (2005) (8)
- Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol. (2014) (8)
- A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion. (2016) (7)
- Cellular prion protein and GABAA receptors: no physical association? (1995) (7)
- Loreclezole as a simple functional marker for homomeric rho type GABA(C) receptors. (2000) (7)
- A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels (2014) (7)
- Demonstration of a voltage dependent calcium current in follicles of the cockroach Nauphoeta cinerea. (1990) (6)
- Ligand-Operated Membrane Channels: GABA (2004) (5)
- Xenopus Oocytes: Optimized Methods for Microinjection, Removal of Follicular Cell Layers, and Fast Solution Changes in Electrophysiological Experiments. (2016) (5)
- Ionic channels: modulation by G proteins and by phosphorylation (1991) (5)
- Influence of the point mutation alpha-1-H101R on the assembly of gamma-aminobutyric acid type A receptors (2005) (5)
- A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained (2010) (5)
- Proximity-accelerated Chemical Coupling Reaction in the Benzodiazepine-binding Site of γ-Aminobutyric Acid Type A Receptors (2007) (4)
- Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei (2017) (3)
- Key receptor involved in neuronal signalling visualized (2018) (3)
- THE BENZODIAZEPINE RECEPTOR COMPLEX - PURIFICATION AND CHARACTERIZATION (1984) (3)
- Microinjection into Xenopus Oocytes (2010) (3)
- Low Expression in Xenopus Oocytes and Unusual Functional Properties of α1β2γ2 GABAA Receptors with Non-Conventional Subunit Arrangement (2017) (3)
- ISOLATION OF A GABA BENZODIAZEPINE RECEPTOR COMPLEX OF BOVINE CEREBRAL-CORTEX (1983) (3)
- Functional sites for anesthetics in GABAA receptors (2017) (3)
- Use of Bicuculline, a GABA Antagonist, as a Template for the Development of a New Class of Ligands Showing Positive Allosteric Modulation of the GABAA Receptor. (2001) (3)
- Proton Translocation Catalyzed by Mitochondrial Cytochrome Oxidase (1979) (2)
- A y-Aminobutyric Acid/Benzodiazepine Receptor Cerebral Cortex PURIFICATION AND PARTIAL CHARACTERIZATION* Complex of Bovine (2001) (2)
- Trypanosoma brucei bloodstream forms depend upon uptake of myo-inositol for 1 Golgi phosphatidylinositol synthesis and normal cell growth 2 3 4 (2016) (2)
- mRNA-induced expression of the cardiac Na/sup +/-Ca/sup 2 +/ exchanger in Xenopus oocytes (1988) (1)
- N-substituted 1- (butyrolactone) -isochinoline for the treatment of nerve disorders (2000) (0)
- Novel Plant Substances Acting as (cid:1) Subunit Isoform-Selective Positive Allosteric Modulators of GABA A Receptors (2005) (0)
- Monepantel irreversibly binds to and opens H. contortus MPTL-1 and C. elegans ACR-20 receptors (2014) (0)
- Distinguishing the two calcium carriers of mitochondria (1979) (0)
- Dangers of 'single-point pharmacology' in receptor studies. GABAA receptor: complex picture confused. (1990) (0)
- Acylation of Proteins in Isolated Mitochondria (1988) (0)
- Biochemical , structural and functional study of ELIC probed with cysteine-reactive benzodiazepine analogs (2012) (0)
- Symmetry considerations provide a new novel open channel blocker of GABA‐A receptors (1059.2) (2014) (0)
- TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes (2017) (0)
- α subunits in GABAA receptors are dispensable for GABA and diazepam action (2017) (0)
- Measurement and perturbation of intracellular calcium (1987) (0)
- GABAA receptor: complex picture confused (1990) (0)
- EDPC: a novel high affinity ligand for the benzodiazepine site on rat GABAA receptors (1999) (0)
- Key receptor involved in neuronal signalling visualized (2018) (0)
- Experiment‐guided virtual screening provides new high affinity ligands for the benzodiazepine site on GABA‐A receptors (654.4) (2014) (0)
- Functional studies on mitochondrial cytochrome c oxidase in natural and reconstituted membrane systems (1980) (0)
- Nonequilibrium Thermodynamics and Cellular Bioenergetics (1988) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Erwin Sigel?
Erwin Sigel is affiliated with the following schools:
