Ettore Novellino

Ettore Novellino's AcademicInfluence.com Rankings

Ettore Novellino

Medical

#1978

World Rank

#2366

Historical Rank

Pharmacology

#199

World Rank

#239

Historical Rank

medical Degrees

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Medical

Ettore Novellino's Degrees

PhD Pharmacology University of Milan
Masters Pharmaceutical Sciences University of Milan
Bachelors Pharmacy University of Milan

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Ettore Novellino's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Therapeutic Potential of Apigenin (2019) (453)
Polyphenols: A concise overview on the chemistry, occurrence, and human health (2019) (368)
Topological characterization of nucleic acid G-quadruplexes by UV absorption and circular dichroism. (2011) (327)
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity (2012) (218)
Nutraceuticals: opening the debate for a regulatory framework (2018) (213)
Nutraceuticals: A paradigm of proactive medicine (2017) (207)
Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. (2019) (188)
Nutraceutical potential and antioxidant benefits of red pitaya (Hylocereus polyrhizus) extracts (2012) (181)
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition (2010) (165)
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis. (2017) (162)
From pharmaceuticals to nutraceuticals: bridging disease prevention and management (2018) (156)
New α-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity (2004) (155)
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. (2007) (148)
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling. (1998) (145)
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors. (2003) (134)
Nutraceuticals - shedding light on the grey area between pharmaceuticals and food (2018) (133)
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. (2006) (132)
Toward a quantitative comparative toxicology of organic compounds. (1989) (125)
An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of multiple sclerosis. (2005) (121)
The G-triplex DNA. (2013) (120)
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide. (2011) (120)
Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity. (2007) (112)
Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential (2017) (108)
Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery. (2014) (107)
New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. (2007) (104)
Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle. (2010) (103)
Docking studies on αvβ3 integrin ligands: Pharmacophore refinement and implications for drug design (2003) (103)
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. (2014) (102)
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives. (2002) (101)
Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations. (2000) (99)
A decade of nutraceutical patents: where are we now in 2018? (2018) (99)
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta (2003) (97)
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1. (2008) (96)
Is diet partly responsible for differences in COVID-19 death rates between and within countries? (2020) (96)
Sampling protein motion and solvent effect during ligand binding (2012) (95)
Simulated gastrointestinal digestion, intestinal permeation and plasma protein interaction of white, green, and black tea polyphenols. (2015) (94)
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. (2008) (92)
5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives. (1999) (90)
Nutraceuticals in hypercholesterolaemia: an overview (2016) (88)
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. (2013) (88)
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells (2014) (87)
Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology (2019) (87)
Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology (2019) (87)
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications. (2011) (87)
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies. (1999) (86)
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action. (2006) (85)
Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations (2017) (83)
[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper. (2017) (83)
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations. (2007) (83)
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders. (2009) (82)
Insights into the Mechanism of Partial Agonism (2007) (82)
Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells (2015) (81)
Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma (2019) (80)
State of the art of Ready-to-Use Therapeutic Food: a tool for nutraceuticals addition to foodstuff. (2013) (79)
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. (2003) (78)
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. (2009) (77)
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity. (2004) (77)
An assessment of the nutraceutical potential of Juglans regia L. leaf powder in diabetic rats. (2017) (74)
Conformational control of integrin-subtype selectivity in isoDGR peptide motifs: a biological switch. (2010) (73)
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. (2001) (73)
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. (2008) (73)
A different molecular mechanism underlying antimicrobial and hemolytic actions of temporins A and L. (2008) (72)
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies. (2009) (72)
STAT-3 inhibitors: state of the art and new horizons for cancer treatment. (2011) (72)
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection. (2017) (72)
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. (2001) (71)
Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis (2016) (71)
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. (2005) (70)
Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor (2013) (70)
Identification of the spiro(oxindole-3,3'-thiazolidine)-based derivatives as potential p53 activity modulators. (2010) (70)
CDC25 phosphatase inhibitors: an update. (2012) (69)
Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands1 (1996) (69)
A new, potent urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge. (2002) (69)
Trichoderma harzianum strain T-22 induces changes in phytohormone levels in cherry rootstocks (Prunus cerasus × P. canescens) (2011) (69)
A Critical Review of Recent CoMFA Applications (1998) (69)
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. (2008) (69)
Abelmoschus esculentus (L.): Bioactive Components’ Beneficial Properties—Focused on Antidiabetic Role—For Sustainable Health Applications (2018) (68)
Ligand Binding Analysis for Human α5β1 Integrin: Strategies for Designing New α5β1 Integrin Antagonists (2005) (68)
May Polyphenols Have a Role Against Coronavirus Infection? An Overview of in vitro Evidence (2020) (68)
Reduced Frizzled Receptor 4 Expression Prevents WNT/&bgr;‐Catenin‐driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease (2017) (68)
Structure-activity relationship, conformational and biological studies of temporin L analogues. (2011) (68)
Calmodulin-dependent kinase II mediates vascular smooth muscle cell proliferation and is potentiated by extracellular signal regulated kinase. (2010) (68)
Mechanistic insight into ligand binding to G-quadruplex DNA (2014) (68)
Resveratrol as a Novel Anti-Herpes Simplex Virus Nutraceutical Agent: An Overview (2018) (66)
Dietary Lignans: Definition, Description and Research Trends in Databases Development (2018) (65)
Colon Bioaccessibility and Antioxidant Activity of White, Green and Black Tea Polyphenols Extract after In Vitro Simulated Gastrointestinal Digestion (2018) (65)
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. (2008) (65)
Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase. (2007) (65)
To Nutraceuticals and Back: Rethinking a Concept (2017) (65)
Combinatorial peptide library screening for discovery of diverse α-glucosidase inhibitors using molecular dynamics simulations and binary QSAR models (2019) (64)
Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. (2011) (63)
Modeling of Cdc25B Dual Specifity Protein Phosphatase Inhibitors: Docking of Ligands and Enzymatic Inhibition Mechanism (2006) (63)
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. (2014) (62)
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. (2008) (62)
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes α5β1 and αvβ6: conformational control through flanking amino acids. (2013) (62)
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins. (2015) (61)
Investigating the mechanism of substrate uptake and release in the glutamate transporter homologue Glt(Ph) through metadynamics simulations. (2012) (61)
Online comprehensive RPLC × RPLC with mass spectrometry detection for the analysis of proteome samples. (2011) (61)
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies. (2009) (61)
In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca). (2013) (60)
N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor. (2004) (60)
The effect of d-amino acid substitution on the selectivity of temporin L towards target cells: identification of a potent anti-Candida peptide. (2013) (59)
Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators. (2013) (58)
Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma (2014) (58)
Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review (2010) (58)
Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. (2014) (58)
Nanopharmaceutics: Part I—Clinical Trials Legislation and Good Manufacturing Practices (GMP) of Nanotherapeutics in the EU (2020) (58)
Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines. (2013) (58)
REACH and in silico methods: an attractive opportunity for medicinal chemists. (2014) (57)
Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives (2014) (57)
Chemical characterization, antioxidant properties, anti-inflammatory activity, and enzyme inhibition of Ipomoea batatas L. leaf extracts (2017) (57)
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. (2008) (57)
Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1). (2014) (56)
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity. (2008) (56)
Antioxidant peptides released from gastrointestinal digestion of “Stracchino” soft cheese: Characterization, in vitro intestinal protection and bioavailability (2016) (56)
Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study (2019) (56)
Effects of Grape Pomace Polyphenolic Extract (Taurisolo®) in Reducing TMAO Serum Levels in Humans: Preliminary Results from a Randomized, Placebo-Controlled, Cross-Over Study (2019) (55)
Nutraceutical potential of monofloral honeys produced by the Sicilian black honeybees (Apis mellifera ssp. sicula). (2012) (55)
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB₁ receptor. (2012) (55)
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. (2010) (54)
Selective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)]4 (2010) (54)
Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials. (2010) (54)
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI‐1) (2010) (54)
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. (2005) (54)
Common G-Quadruplex Binding Agents Found to Interact With i-Motif-Forming DNA: Unexpected Multi-Target-Directed Compounds (2018) (53)
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. (2009) (53)
Thiazolidin-4-one formation. Mechanistic and synthetic aspects of the reaction of imines and mercaptoacetic acid under microwave and conventional heating. (2004) (53)
Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors. (2005) (52)
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis. (2009) (52)
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. (2012) (52)
Regulation of HuR structure and function by dihydrotanshinone-I (2017) (51)
Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity. (2007) (51)
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma. (2016) (51)
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation. (2011) (51)
Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus. (2009) (51)
Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer (2017) (50)
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. (2008) (50)
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands. (2016) (50)
Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and nanonutraceuticals research (2020) (50)
Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death. (2012) (50)
G-triplex structure and formation propensity (2014) (50)
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target. (2005) (49)
Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking (2015) (49)
Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism (2018) (49)
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column. (2003) (49)
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. (2005) (49)
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity. (2005) (49)
Protein Flexibility in Virtual Screening: The BACE-1 Case Study (2012) (48)
Disease‐Modifying Anti‐Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with β‐Amyloid Aggregation (2014) (48)
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors. (2012) (48)
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists. (2001) (48)
Use of comparative molecular field analysis and cluster analysis in series design (1995) (47)
Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors. (2003) (47)
Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds. (2020) (47)
Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage (2007) (47)
Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening. (2012) (47)
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase (2014) (46)
Conformational Analysis of Furanoid ε-Sugar Amino Acid Containing Cyclic Peptides by NMR Spectroscopy, Molecular Dynamics Simulation, and X-ray Crystallography: Evidence for a Novel Turn Structure (2003) (46)
An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics (2020) (46)
Biological activity of 3-chloro-azetidin-2-one derivatives having interesting antiproliferative activity on human breast cancer cell lines. (2013) (46)
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity. (2002) (46)
Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α. (2012) (46)
A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. (2001) (46)
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands. (2013) (46)
Nanopharmaceutics: Part II—Production Scales and Clinically Compliant Production Methods (2020) (45)
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant. (2006) (45)
Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives. (2016) (45)
Emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer. (2014) (44)
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases. (2003) (44)
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model. (2008) (44)
Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies. (2005) (44)
Human Integrin αvβ5: Homology Modeling and Ligand Binding (2004) (44)
Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities (2008) (44)
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function. (2009) (44)
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach. (2013) (44)
Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships. (2008) (44)
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. (2014) (43)
Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence. (2013) (43)
New insight into the mechanism of action of the temporin antimicrobial peptides. (2010) (43)
Melanocortin MC₄ receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia. (2011) (43)
Development of an improved online comprehensive hydrophilic interaction chromatography × reversed-phase ultra-high-pressure liquid chromatography platform for complex multiclass polyphenolic sample analysis. (2017) (43)
Probiotic species in the modulation of the anticancer immune response. (2017) (43)
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. (2012) (43)
Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. (2008) (43)
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. (2015) (43)
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations. (2000) (43)
Looking for Efficient G‐Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug‐Like Molecules (2015) (43)
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation. (2011) (42)
Antitumor agents. 1. Synthesis, biological evaluation, and molecular modeling of 5H-pyrido[3,2-a]phenoxazin-5-one, a compound with potent antiproliferative activity. (2002) (42)
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies (2020) (42)
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage (2016) (42)
Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.). (2018) (42)
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. (2006) (41)
Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria. (2014) (41)
Differential scanning calorimetry to investigate G-quadruplexes structural stability. (2013) (41)
State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders. (2012) (40)
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. (2005) (40)
Design, synthesis, conformational analysis, and biological studies of urotensin-II lactam analogues. (2002) (40)
Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues. (2010) (40)
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes. (2014) (40)
Progresses in the pursuit of aldose reductase inhibitors: the structure-based lead optimization step. (2012) (40)
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening. (2009) (39)
Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation. (2013) (39)
Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action. (2012) (39)
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors. (2009) (39)
Exogenous opioid peptides derived from food proteins and their possible uses as dietary supplements: A critical review (2018) (39)
New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. (2011) (39)
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils. (2011) (39)
Unraveling the active conformation of urotensin II. (2004) (39)
Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors. (2013) (39)
Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system. (2005) (39)
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation. (2013) (38)
Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells. (2017) (38)
Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors (2014) (38)
Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca). (2013) (38)
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis. (2010) (38)
Further structure–activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5 (2007) (38)
Effect of restriction vegan diet's on muscle mass, oxidative status, and myocytes differentiation: A pilot study (2018) (37)
Imaging of αvβ3 Expression by a Bifunctional Chimeric RGD Peptide not Cross-Reacting with αvβ5 (2009) (37)
Noncanonical DNA Secondary Structures as Drug Targets: the Prospect of the i‐Motif (2014) (37)
Alanine scanning analysis and structure–function relationships of the frog‐skin antimicrobial peptide temporin‐1Ta (2011) (37)
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. (2015) (37)
Tryptophan Derivatives from a Mediterranean Anthozoan, Astroides calycularis (1985) (37)
Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. (2006) (37)
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis (2013) (37)
Peptidome profiles and bioactivity elucidation of buffalo-milk dairy products after gastrointestinal digestion. (2018) (37)
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity. (1996) (37)
Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives. (2003) (37)
Discovery of arginine-containing tripeptides as a new class of pancreatic lipase inhibitors. (2019) (36)
Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance (2015) (36)
Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer. (2013) (36)
Rational design of the first difluorostatone-based PfSUB1 inhibitors. (2014) (36)
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments (2015) (36)
Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism. (2010) (36)
Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activity. (2014) (35)
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors. (2014) (35)
New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation. (2007) (35)
Modulation of the JAK/ERK/STAT signaling in melanocortin-induced inhibition of local and systemic responses to myocardial ischemia/reperfusion. (2013) (35)
The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors. (2013) (35)
Development of peptidomimetic boronates as proteasome inhibitors. (2013) (35)
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors. (2014) (35)
Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models. (2010) (35)
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. (2008) (35)
Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells (2011) (34)
[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. (2001) (34)
Linking CoMFA and protein homology models of enzyme-inhibitor interactions: an application to non-steroidal aromatase inhibitors. (2000) (34)
ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice (2020) (34)
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. (2012) (34)
G-quadruplex on oligo affinity support (G4-OAS): an easy affinity chromatography-based assay for the screening of G-quadruplex ligands. (2014) (34)
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes. (2017) (34)
Pharmacological folding chaperones act as allosteric ligands of Frizzled4. (2015) (34)
Homology Modeling of NR2B Modulatory Domain of NMDA Receptor and Analysis of Ifenprodil Binding (2007) (34)
ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy” (2019) (34)
Synthesis and biological evaluation of new N-alkylcarbazole derivatives as STAT3 inhibitors: preliminary study. (2013) (34)
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators. (2016) (34)
Spirohydantoin derivatives of thiopyrano[2,3-b]pyridin-4(4H)-one as potent in vitro and in vivo aldose reductase inhibitors. (2005) (33)
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds (2015) (33)
Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells (2014) (33)
Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria) (2016) (33)
Antioxidant peptides from "Mozzarella di Bufala Campana DOP" after simulated gastrointestinal digestion: In vitro intestinal protection, bioavailability, and anti-haemolytic capacity (2015) (33)
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity. (2008) (33)
The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: biophysical and molecular modeling studies. (2011) (33)
Effect of Grape Pomace Polyphenols With or Without Pectin on TMAO Serum Levels Assessed by LC/MS-Based Assay: A Preliminary Clinical Study on Overweight/Obese Subjects (2019) (33)
Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. (2010) (33)
Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors. (2013) (33)
Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor. (1996) (33)
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds (2015) (33)
NMR spectrometers as "magnetic tongues": prediction of sensory descriptors in canned tomatoes. (2011) (33)
Occurrence of two new mycosporine-like aminoacids, mytilins A and B in the edible mussel, mytilus galloprovincialis☆ (1979) (33)
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. (2009) (32)
Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors. (2008) (32)
Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry. (2018) (32)
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. (1999) (32)
Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: introducing hydroxamic acids to the MIDAS to tune potency and selectivity. (2009) (32)
A Gαs Carboxyl-Terminal Peptide Prevents Gs Activation by the A2A Adenosine Receptor (2000) (32)
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase. (2015) (32)
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. (2011) (32)
Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. (2005) (32)
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication. (2019) (32)
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. (2007) (32)
The design of multitarget ligands for chronic and neuropathic pain. (2015) (32)
Novel α-MSH Peptide Analogues with Broad Spectrum Antimicrobial Activity (2013) (32)
Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities. (2017) (31)
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies. (2018) (31)
Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity. (2005) (31)
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors. (2018) (31)
Application of "magnetic tongue" to the sensory evaluation of extra virgin olive oil. (2013) (31)
Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. (2014) (31)
Ensemble‐Docking Approach on BACE‐1: Pharmacophore Perception and Guidelines for Drug Design (2007) (31)
Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity. (2012) (31)
Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial. (2017) (31)
Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav2.2 Blocker Multitarget Ligands (2015) (31)
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. (2005) (31)
Toxicity of aflatoxin B1 towards the vitamin D receptor (VDR). (2015) (31)
Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial (2019) (31)
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands. (1996) (31)
Sterol composition of some mediterranean green algae (1982) (30)
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity (2014) (30)
A Convenient One Step Synthesis of 5-Cystein-S-yldopa Using Ceric Ammonium Nitrate (1986) (30)
Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays. (2013) (30)
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. (2001) (30)
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. (2012) (30)
Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity. (2013) (30)
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. (2009) (30)
Structure—affinity relationship studies on benzotriazole derivatives binding to 5-HT receptor subtypes (1996) (30)
Exploring the nutraceutical potential of polyphenols from black, green and white tea infusions - an overview. (2015) (30)
Diarylheterocycle Core Ring Features Effect in Selective COX‐1 Inhibition (2012) (30)
Lower incidence of macrovascular complications in patients on insulin glargine versus those on basal human insulins: a population-based cohort study in Italy. (2014) (30)
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents. (2005) (30)
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis (2012) (29)
In vitro hypoglycaemic and hypolipidemic potential of white tea polyphenols. (2013) (29)
Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties. (2009) (29)
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. (2015) (29)
Targeting the BCL2 Gene Promoter G‐Quadruplex with a New Class of Furopyridazinone‐Based Molecules (2018) (29)
Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial (2017) (29)
Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives. (2007) (29)
Structural insights into amyloid structures of the C-terminal region of nucleophosmin 1 in type A mutation of acute myeloid leukemia. (2019) (29)
Cdc25B phosphatase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. (2008) (29)
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data. (2015) (29)
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells. (2012) (29)
Detailed polyphenolic profiling of Annurca apple (M. pumila Miller cv Annurca) by a combination of RP-UHPLC and HILIC, both hyphenated to IT-TOF mass spectrometry. (2015) (29)
Novel α-melanocyte stimulating hormone peptide analogues with high candidacidal activity (2003) (29)
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents. (2003) (29)
Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone (1995) (29)
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent. (2008) (29)
Novel and Selective αvβ3 Receptor Peptide Antagonist: Design, Synthesis, and Biological Behavior (2006) (28)
Obestatin conformational features: a strategy to unveil obestatin's biological role? (2007) (28)
Designed glycopeptides with different beta-turn types as synthetic probes for the detection of autoantibodies as biomarkers of multiple sclerosis. (2008) (28)
Identification of novel interactors of human telomeric G-quadruplex DNA. (2015) (28)
Study of Benzodiazepines Receptor Sites Using a Combined QSAR‐CoMFA Approach (1992) (28)
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H. (2016) (28)
Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation. (2013) (28)
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives. (2013) (28)
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARα and PPARγ Agonist Activity (2007) (28)
Phenolic Analysis and In Vitro Biological Activity of Red Wine, Pomace and Grape Seeds Oil Derived from Vitis vinifera L. cv. Montepulciano d’Abruzzo (2021) (28)
Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation. (2015) (28)
Effects of Annurca apple polyphenols on lipid metabolism in HepG2 cell lines: A source of nutraceuticals potentially indicated for the metabolic syndrome (2014) (28)
CDC25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy. (2009) (28)
HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation? (2018) (27)
Red Propolis and Its Dyslipidemic Regulator Formononetin: Evaluation of Antioxidant Activity and Gastroprotective Effects in Rat Model of Gastric Ulcer (2020) (27)
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists. (2002) (27)
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. (2012) (27)
Fermentation of Foods and Beverages as a Tool for Increasing Availability of Bioactive Compounds. Focus on Short-Chain Fatty Acids (2020) (27)
Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors (2017) (26)
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. (2009) (26)
Biophysical and biochemical characterization of a liposarcoma‐derived recombinant MnSOD protein acting as an anticancer agent (2008) (26)
Chemical composition and biological activity of Capparis spinosa L. from Lipari Island (2019) (26)
Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity. (2006) (26)
Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. (2008) (26)
Bio-Inspired Dual Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives. (2020) (26)
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue. (2014) (26)
Allosteric modulators of human A2B adenosine receptor. (2014) (26)
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. (2010) (25)
Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. (2014) (25)
Detailed peptide profiling of “Scotta”: from a dairy waste to a source of potential health-promoting compounds (2016) (25)
Mimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer (2018) (25)
Exploring the Nutraceutical Potential of Dried Pepper Capsicum annuum L. on Market from Altino in Abruzzo Region (2020) (25)
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. (2011) (25)
Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism (2015) (25)
Urotensin-II receptor ligands. From agonist to antagonist activity. (2005) (25)
The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II. (2016) (25)
Quinoline‐Based p300 Histone Acetyltransferase Inhibitors with Pro‐apoptotic Activity in Human Leukemia U937 Cells (2014) (25)
Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein (2019) (25)
Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex (2014) (24)
Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion (2014) (24)
Use of NMR in profiling of cocaine seizures. (2013) (24)
Identification of a new series of amides as non-covalent proteasome inhibitors. (2014) (24)
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization. (2012) (24)
Novel cyclic biphalin analogue with improved antinociceptive properties. (2014) (24)
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity. (2008) (24)
Membrane charge dependent states of the beta-amyloid fragment Abeta (16-35) with differently charged micelle aggregates. (2010) (24)
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides. (2015) (24)
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies. (2012) (24)
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues. (2011) (24)
Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization. (2010) (24)
Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors (2013) (24)
Binding of the hemopressin peptide to the cannabinoid CB1 receptor: structural insights. (2010) (24)
An efficient approach for monosulfide bridge formation in solid-phase peptide synthesis (2004) (24)
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials (2009) (24)
Synthesis and Biological Evaluation of 5H-Indolo [3,2-b][1,5]Benzothiazepine Derivatives, Designed as Conformationally Constrained Analogues of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor L-737,126 (1998) (24)
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. (2019) (23)
Synthesis and Pharmacological Evaluation of Some 4‐Oxo‐quinoline‐2‐carboxylic Acid Derivatives as Anti‐inflammatory and Analgesic Agents (2010) (23)
Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists (2017) (23)
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas. (2016) (23)
Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. (2018) (23)
Occurrence of mycosporine related compounds in sea urchin eggs (1986) (23)
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease. (2019) (23)
p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. (2014) (23)
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors (2017) (23)
Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells. (2017) (23)
Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals (2017) (23)
Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay (2014) (23)
Tailoring a lead-like compound targeting multiple G-quadruplex structures. (2019) (23)
Use of the hydrogen bond potential function in a comparative molecular field analysis (CoMFA) on a set of benzodiazepines (1993) (23)
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies. (1994) (23)
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. (2009) (23)
Comparative Molecular Field Analysis on a Set of Muscarinic Agonists (1991) (23)
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists. (2016) (23)
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. (2007) (23)
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury. (2018) (23)
Design and Synthesis of New Cell Penetrating Peptides: Diffusion and Distribution Inside the Cornea. (2016) (23)
Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016) (2016) (23)
From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands. (2018) (22)
Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure. (2019) (22)
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. (2012) (22)
Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We? (2020) (22)
DPP-4 inhibitors: a patent review (2012 – 2014) (2015) (22)
New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide. (2009) (22)
Hemopressin Peptides as Modulators of the Endocannabinoid System and their Potential Applications as Therapeutic Tools. (2016) (22)
Shading the TRF2 recruiting function: a new horizon in drug development. (2014) (22)
Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies (2019) (22)
The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin‐L (2019) (22)
Bioassay-guided identification of the antihyperglycaemic constituents of walnut (Juglans regia) leaves (2016) (22)
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists. (2012) (21)
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3. (2017) (21)
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids. (2006) (21)
A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. (2018) (21)
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. (2001) (21)
Identification of Structural Features of 2‐Alkylidene‐1,3‐Dicarbonyl Derivatives that Induce Inhibition and/or Activation of Histone Acetyltransferases KAT3B/p300 and KAT2B/PCAF (2015) (21)
Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine (2016) (21)
Urotensin‐II receptor is over‐expressed in colon cancer cell lines and in colon carcinoma in humans (2014) (21)
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops (2018) (21)
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). (2002) (21)
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. (2008) (21)
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: a docking and molecular dynamics study. (2007) (21)
Design, synthesis, and cytotoxic evaluation of acyl derivatives of 3-aminonaphtho[2,3-b]thiophene-4,9-dione, a quinone-based system. (2011) (20)
Characterization of a selective CaMKII peptide inhibitor. (2013) (20)
Design and synthesis of spirotryprostatin-inspired diketopiperazine systems from prolyl spirooxoindolethiazolidine derivatives. (2010) (20)
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures? (2017) (20)
Discovery of novel amide tripeptides as pancreatic lipase inhibitors by virtual screening (2019) (20)
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists. (2012) (20)
Lignans: Quantitative Analysis of the Research Literature (2020) (20)
Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure. (2014) (20)
A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation: Results of a Randomized Trial (2017) (20)
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands. (2016) (20)
Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening. (2016) (20)
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions (2016) (20)
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor. (1994) (20)
Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase. (2014) (20)
Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors. (2013) (20)
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies. (2011) (20)
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer. (2017) (20)
Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs (2016) (20)
Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement. (2015) (20)
Reaction between (Z)-arylchlorooximes and α-isocyanoacetamides: a procedure for the synthesis of aryl-α-ketoamide amides. (2014) (19)
Predictive Structure-Based Toxicology Approaches To Assess the Androgenic Potential of Chemicals. (2017) (19)
Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. (2014) (19)
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. (2015) (19)
Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models. (2013) (19)
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists. (2015) (19)
Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation (2018) (19)
A1 adenosine receptor antagonists, 3‐aryl[1,2,4]triazino[4,3‐a]benzimidazol‐4‐(10H)‐ones (ATBIs) and N‐alkyl and N‐acyl‐(7‐substituted‐2‐phenylimidazo[1,2‐a][1,3,5]triazin‐4‐yl)amines (ITAs): Different recognition of bovine and human binding sites (2004) (19)
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist. (2017) (19)
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors. (2014) (19)
Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells (2020) (19)
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds. (2008) (19)
Antioxidant and antimicrobial properties of polyphenolic fractions from selected Moroccan red wines. (2011) (19)
(1S,3R,4S,5R)5-O-Caffeoylquinic acid: isolation, stereo-structure characterization and biological activity. (2015) (19)
Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands. (2015) (19)
Mycosporine aminoacids and related compounds from the eggs of fishes (2010) (19)
Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells. (2018) (19)
New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site (1997) (19)
Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of action (2021) (19)
Arylthiopyrrole (AThP) Derivatives as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 2) (2006) (18)
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition. (2013) (18)
Chemical composition, antioxidant and antimicrobial properties of Rapa Catozza Napoletana (Brassica rapa L. var. rapa DC.) seed meal, a promising protein source of Campania region (southern Italy) horticultural germplasm. (2012) (18)
Structure−Activity Relationship Studies Optimizing the Antiproliferative Activity of Novel Cyclic Somatostatin Analogues Containing a Restrained Cyclic β-Amino Acid† (2005) (18)
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists (2013) (18)
Cycloaddition reactions of thiazolidine derivatives. An approach to the synthesis of new functionalized heterocyclic systems (2001) (18)
In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors (2016) (18)
The Pomace Extract Taurisolo Protects Rat Brain From Ischemia-Reperfusion Injury (2020) (18)
Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors (2016) (18)
3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands. (2000) (18)
Binding Site of Loperamide: Automated Docking of Loperamide in Human μ‐ and δ‐Opioid Receptors (2008) (18)
Spiro[(dihydropyrazin-2,5-dione)-6,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)]-based cytotoxic agents: structure-activity relationship studies on the substituent at N4-position of the diketopiperazine domain. (2008) (18)
An investigation into the origin of the biased agonism associated with the urotensin II receptor activation (2015) (18)
A Membrane-Permeable Peptide Containing the Last 21 Residues of the GαS Carboxyl Terminus Inhibits GS-Coupled Receptor Signaling in Intact Cells: Correlations between Peptide Structure and Biological Activity (2006) (18)
Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese (2019) (18)
Synthesis of aminocarbonyl N-acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids. (2014) (18)
A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells (2019) (18)
First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment (2021) (17)
Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones. (2015) (17)
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations. (2009) (17)
Amyloid fibers deriving from the aromatic core of C-terminal domain of nucleophosmin 1. (2019) (17)
The acute myeloid leukemia‐associated Nucleophosmin 1 gene mutations dictate amyloidogenicity of the C‐terminal domain (2019) (17)
Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors. (2017) (17)
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment. (2017) (17)
Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation (2018) (17)
Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design. (2003) (17)
Structural studies on Hgr3 orphan receptor ligand prolactin-releasing peptide. (2002) (17)
Design and Synthesis of Melanocortin Peptides with Candidacidal and Anti-TNF-α Properties (2005) (17)
Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies. (2014) (17)
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. (2007) (17)
Designed glucopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. (2012) (17)
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. (2011) (17)
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening. (2017) (17)
Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells (2017) (17)
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. (2008) (17)
Synthesis and pharmacological evaluation of a set of N-[2-(alkylamino)ethyl]benzotriazol-X-yl isobutyramides acting as local anesthetics (1996) (16)
Nucleophosmin-1 regions associated with acute myeloid leukemia interact differently with lipid membranes. (2018) (16)
In Vitro Characterization, Modelling, and Antioxidant Properties of Polyphenon-60 from Green Tea in Eudragit S100-2 Chitosan Microspheres (2020) (16)
Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents (2014) (16)
Antitumor agents 4. Characterization of free radicals produced during reduction of the antitumor drug 5H-pyridophenoxazin-5-one: an EPR study. (2003) (16)
Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer. (2015) (16)
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides. (2016) (16)
Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces. (2017) (16)
Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques. (2016) (16)
A practical, green, and selective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems using alumina-catalyzed Michael addition reaction (2008) (16)
Production of enniatins A, A1, B, B1, B4, J1 by Fusarium tricinctum in solid corn culture: structural analysis and effects on mitochondrial respiration. (2013) (16)
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations. (2019) (16)
New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (2014) (16)
tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells (2013) (16)
Urotensin-II receptor antagonists. (2006) (16)
Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies (2019) (16)
On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity (2019) (16)
Development of novel cyclic peptides as pro-apoptotic agents. (2016) (16)
( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation. (2018) (16)
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2. (2015) (16)
Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies. (2016) (16)
Structure‐Based Design of Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors using a Virtual Fragment Growing Optimization Scheme (2016) (16)
Urotensin‐II receptor peptide agonists (2004) (16)
Sirtuins and SIRT6 in Carcinogenesis and in Diet (2019) (16)
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein. (2011) (16)
Synthesis and pharmacological characterization of conformationally restricted retigabine analogues as novel neuronal Kv7 channels activators. (2019) (15)
Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats (2020) (15)
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (2011) (15)
Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics (2020) (15)
Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin. (2017) (15)
Recent structure-activity studies of the peptide hormone urotensin-II, a potent vasoconstrictor. (2004) (15)
Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. (2019) (15)
Coffee and Depression: A Short Review of Literature. (2015) (15)
Rapid and Efficient Methodology to Perform Macrocyclization Reactions in Solid-Phase Peptide Chemistry (2003) (15)
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor. (2005) (15)
Three-dimensional structure of the α-MSH-derived candidacidal peptide [Ac-CKPV]2 (2008) (15)
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. (2013) (15)
Pyroglutamic Acid Derivatives: Building Blocks for Drug Discovery (2014) (15)
Nutraceutical value and toxicological profile of selected red wines from Morocco. (2011) (15)
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors. (2018) (15)
Fruit‐based juices: Focus on antioxidant properties—Study approach and update (2019) (15)
Plant-derived peptides rubiscolin-6, soymorphin-6 and their c-terminal amide derivatives: Pharmacokinetic properties and biological activity (2020) (15)
A stereoselective approach to peptidomimetic BACE1 inhibitors. (2013) (15)
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma. (2016) (15)
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site. (2012) (15)
Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO‐Like Cyclic Sulfones as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors (2006) (14)
Approaches to Three‐Dimensional Quantitative Structure‐Activity Relationships (2007) (14)
Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents. (2017) (14)
A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome. (2016) (14)
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor. (2015) (14)
Constrained Peptides with Fine‐Tuned Flexibility Inhibit NF‐Y Transcription Factor Assembly (2019) (14)
MHC class II invariant chain–adjuvanted viral vectored vaccines enhances T cell responses in humans (2020) (14)
Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges. (2014) (14)
Structure–function Relationships and Conformational Properties of α‐MSH(6–13) Analogues with Candidacidal Activity (2007) (14)
Endogenous Urotensin II Selectively Modulates Erectile Function through eNOS (2012) (14)
Antioxidant and antimicrobial properties of traditional green and purple “Napoletano” basil cultivars (Ocimum basilicum L.) from Campania region (Italy) (2017) (14)
Malaria chemotherapy: recent advances in drug development. (2010) (14)
Novel temporin L antimicrobial peptides: promoting self-assembling by lipidic tags to tackle superbugs (2020) (14)
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. (2018) (14)
Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. (2018) (14)
Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells (2016) (14)
A novel approach to the synthesis of diaza-bridged heterocycle derivatives (2006) (14)
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor (2016) (14)
Urotensin II: a novel target in human corpus cavernosum. (2010) (14)
Synthesis, local anesthetic activity and QSAR studies for a set of N-[2-(alkylamino)ethyl]benzotriazol-x-yl acetamides (1995) (14)
Olive Leaves and Hibiscus Flowers Extracts-Based Preparation Protect Brain from Oxidative Stress-Induced Injury (2020) (14)
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies. (2013) (14)
Derivatives of Benzimidazol‐2‐ylquinoline and Benzimidazol‐2‐ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility (2011) (14)
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents. (2015) (14)
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. (2017) (13)
A Fhit-mimetic peptide suppresses annexin A4-mediated chemoresistance to paclitaxel in lung cancer cells (2016) (13)
Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. (2018) (13)
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides. (2006) (13)
From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum (2014) (13)
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase. (2020) (13)
Synthesis and Pharmacological Activity of 2‐(substituted)‐3‐{2‐[(4‐phenyl‐4‐cyano)piperidino]ethyl}‐1,3‐thiazolidin‐4‐ones (2006) (13)
Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. (2000) (13)
Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives. (2019) (13)
Managing Allergic Rhinitis in the Pharmacy: An ARIA Guide for Implementation in Practice (2020) (13)
Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors (2015) (13)
A novel quinone‐based derivative (DTNQ‐Pro) induces apoptotic death via modulation of heat shock protein expression in Caco‐2 cells (2010) (13)
WNT Inhibitory Activity of Malus Pumila miller cv Annurca and Malus domestica cv Limoncella Apple Extracts on Human Colon-Rectal Cells Carrying Familial Adenomatous Polyposis Mutations (2017) (13)
Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells. (2016) (13)
Temporin L-derived peptide as a regulator of the acute inflammatory response in zymosan-induced peritonitis. (2019) (13)
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis. (2019) (13)
New anticancer agents mimicking protein recognition motifs. (2013) (13)
Synthesis of new β-turn dipeptide mimetic based on tetrahydroisoquinoline moiety (2002) (13)
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists. (2011) (13)
A NOVEL ROUTE TO 4H-1,4-BENZOTHIAZINES BY RING-EXPANSION OF 2,3-DIHYDRO-1,3-BENZOTHIAZOLES (1977) (13)
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands. (2007) (13)
Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile. (2017) (13)
Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇. (2017) (13)
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy. (2016) (13)
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates (2016) (13)
SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors. (2014) (13)
Conformational Stability of Aβ‐(25–35) in the Presence of Thiazolidine Derivatives (2007) (13)
Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation (2014) (12)
A New Synthesis of 4H-1,4-Thiazines and Benzothiazines (1978) (12)
Targeting the KRAS Oncogene: Synthesis, Physicochemical and Biological Evaluation of Novel G-Quadruplex DNA Binders. (2020) (12)
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity (2015) (12)
Synthesis, Characterization, and DNA Binding Profile of a Macrocyclic β-Sheet Analogue of ARC Protein. (2015) (12)
Computer-aided structure-affinity relationships in a set of piperazine and 3,8-diazabicyclo[3.2.1]octane derivatives binding to the μ-opioid receptor (1993) (12)
Facile Baeyer-Villiger oxidation of cyclic ketones: Conventional versus microwave-assisted approach (2015) (12)
Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition (2016) (12)
Antimicrobial Peptide Temporin-L Complexed with Anionic Cyclodextrins Results in a Potent and Safe Agent against Sessile Bacteria. (2020) (12)
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies (2012) (12)
Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells (2019) (12)
Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor. (2011) (12)
POTENT, EFFICACIOUS AND STABLE CYCLIC OPIOID PEPTIDES WITH LONG LASTING ANTINOCICEPTIVE EFFECT AFTER PERIPHERAL ADMINISTRATION. (2019) (12)
A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex. (2014) (12)
New insight into the binding mode of peptides at urotensin‐II receptor by Trp‐constrained analogues of P5U and urantide (2013) (12)
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans. (2019) (12)
A Pilot Screening of Agro-Food Waste Products as Sources of Nutraceutical Formulations to Improve Simulated Postprandial Glycaemia and Insulinaemia in Healthy Subjects (2020) (12)
NMR Assignment of N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide Seized as Herbal Incense for the First Time in Italy (2014) (12)
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75. (2015) (12)
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors. (1995) (12)
Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode (2015) (11)
DTNQ-Pro, a Mimetic Dipeptide, Sensitizes Human Colon Cancer Cells to 5-Fluorouracil Treatment (2013) (11)
Nanocarriers Conjugated with Cell Penetrating Peptides: New Trojan Horses by Modern Ulysses. (2016) (11)
Urantide Conformation and Interaction with the Urotensin‐II Receptor (2014) (11)
The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver (2020) (11)
N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors. (2012) (11)
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis (2014) (11)
Design of novel nicotinic ligands through 3D database searching. (2005) (11)
Lower Rate of Cardiovascular Complications in Patients on Bolus Insulin Analogues: A Retrospective Population-Based Cohort Study (2013) (11)
Co-polymerization of dopa and cysteinyldopa in melanogenesis in vitro (1980) (11)
Identification of novel indole derivatives acting as inhibitors of the Keap1–Nrf2 interaction (2019) (11)
New alpha-(N)-heterocyclichydrazones: evaluation of anticancer, anti-HIV and antimicrobial activity. (2004) (11)
Canned bluefin tuna, an in vitro cardioprotective functional food potentially safer than commercial fish oil based pharmaceutical formulations. (2014) (11)
The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: a successful drug discovery tale. (2014) (11)
The Glycan Role in the Glycopeptide Immunogenicity Revealed by Atomistic Simulations and Spectroscopic Experiments on the Multiple Sclerosis Biomarker CSF114(Glc) (2015) (11)
Identification of cysteinyldopa‐derived units in eumelanins from mammalian eyes (1981) (11)
Novel propanamides as fatty acid amide hydrolase inhibitors. (2017) (11)
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library. (2013) (11)
Anthocyanin composition and extractability in berry skin and wine of Vitis vinifera L. cv. Aglianico. (2011) (11)
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island (2018) (11)
Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries? (2020) (10)
Some new aspects on the chemistry of 1,4‐benzoxazines (1985) (10)
Challenging clinically unresponsive medullary thyroid cancer: Discovery and pharmacological activity of novel RET inhibitors. (2018) (10)
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II). (2019) (10)
Amphoteric 2-(sulfonylamino)benzaldehydes, secondary amines and isocyanides in the multicomponent synthesis of elusive N-alkyl-2,3-diaminoindoles (2017) (10)
1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: an effective scaffold for the design of either CB1 or CB2 receptor ligands. (2011) (10)
A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-β-carboline derivatives using the Pictet–Spengler reaction (2004) (10)
Oleuropein as a novel anti-diabetic nutraceutical. An overview (2018) (10)
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative ability (2017) (10)
Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration. (2018) (10)
Synthesis and Pharmacological Evaluation of Analogs of Indole‐Based Cannabimimetic Agents (2010) (10)
Exploiting the 4-Phenylquinazoline Scaffold for the Development of High Affinity Fluorescent Probes for the Translocator Protein (TSPO). (2017) (10)
Reaction between quinone and thiazolidine. A study on the formation mechanism of new antiproliferative quinolindiones (2004) (10)
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. (2009) (10)
A nutraceutical formulation based on Annurca apple polyphenolic extract is effective on intestinal cholesterol absorption: A randomised, placebo-controlled, crossover study (2018) (10)
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists. (2005) (10)
A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides (2013) (10)
Opioid Receptor Activity and Analgesic Potency of DPDPE Peptide Analogues Containing a Xylene Bridge. (2017) (10)
Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. (2018) (10)
Homology modelling and docking studies on Varicella Zoster Virus Thymidine kinase. (2003) (10)
Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors. (2019) (10)
Structure‐activity studies of peptidomimetics based on kinase‐inhibitory region of suppressors of cytokine signaling 1 (2018) (10)
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity. (2017) (10)
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. (2019) (9)
Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets † (2020) (9)
Molecular Docking for Predictive Toxicology. (2018) (9)
Interactions of cisplatin analogues with lysozyme: a comparative analysis (2017) (9)
Synthesis, antimicrobial data and correlation analysis in a set of 2-alkyl-5-amidobenzotriazoles (1992) (9)
Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation (2017) (9)
Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes (2019) (9)
Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase (2016) (9)
GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1. (2015) (9)
Conformational studies on a synthetic C-terminal fragment of the alpha subunit of G(S) proteins. (2000) (9)
Molecular Scavengers, Oxidative Stress and Cardiovascular Disease (2019) (9)
Synthesis of Novel Indole-Based Ring Systems by Acid-Catalysed Condensation from α-Amino Aldehydes and L-Trp-OMe (2008) (9)
Stabile Peptide statt “gestapelte Peptide”: hochaffine αvβ6‐selektive Integrinliganden (2016) (9)
New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid. (2015) (9)
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors. (1998) (9)
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme. (2021) (9)
Cholest-5-ene-2.alpha.,3.alpha.,7.beta.,15.beta.,18-pentol 2,7,15,18-tetraacetate, a novel highly hydroxylated sterol from the marine hydroid Eudendrium glomeratum (1985) (9)
Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. (2006) (9)
Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function (2021) (8)
Assessing the influence of pH and cationic strength on i-motif DNA structure (2019) (8)
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N‐Dialkyl‐2‐arylindol‐3‐ylglyoxylamides (2017) (8)
A galpha(s) carboxyl-terminal peptide prevents G(s) activation by the A(2A) adenosine receptor. (2000) (8)
Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives (2020) (8)
Aryl azides as forgotten electrophiles in the Van Leusen reaction: a multicomponent transformation affording 4-tosyl-1-arylimidazoles. (2019) (8)
Long lasting inhibition of Mdm2-p53 interaction potentiates mesenchymal stem cell differentiation into osteoblasts. (2019) (8)
Croton argyrophyllus Kunth Essential Oil-Loaded Solid Lipid Nanoparticles: Evaluation of Release Profile, Antioxidant Activity and Cytotoxicity in a Neuroblastoma Cell Line (2020) (8)
Antifungal peptides at membrane interaction. (2012) (8)
Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR (1994) (8)
In Silico Identification of Tripeptides as Lead Compounds for the Design of KOR Ligands (2021) (8)
A New Series of 1,3‐Dihidro‐Imidazo[1,5‐c]thiazole‐5,7‐Dione Derivatives: Synthesis and Interaction with Aβ(25‐35) Amyloid Peptide (2009) (8)
4‐amino‐6‐alkyloxy‐2‐alkylthiopyrimidine derivatives as novel non‐nucleoside agonists for the adenosine A1 receptor (2016) (8)
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach. (2020) (7)
Opposite Modulation of Cell Migration by Distinct Subregions of Urokinase Connecting Peptide (2013) (7)
Synthesis and antimicrobial activities of 5-amidobenzotriazole derivatives (1990) (7)
Developing Cyclic Opioid Analogues: Fluorescently Labeled Bioconjugates of Biphalin. (2020) (7)
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors. (2018) (7)
Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses (2020) (7)
How are thermodynamically stable G-quadruplex–duplex hybrids? (2015) (7)
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric Acids. (2016) (7)
Novel alpha-melanocyte stimulating hormone peptide analogues with high candidacidal activity. (2003) (7)
Trimeric aldolization product of 1,4-benzothiazine (1977) (7)
Driving forces in the delivery of penetratin conjugated G protein fragment. (2007) (7)
HCV-targeted antivirals: current status and future challenges. (2014) (7)
Combined HAT/EZH2 modulation leads to cancer-selective cell death (2018) (7)
Plasma lipid lowering effect by a novel chia seed based nutraceutical formulation (2018) (7)
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues (2013) (7)
Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells (2003) (7)
Molecular signaling involving intrinsically disordered proteins in prostate cancer (2016) (7)
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers. (2018) (7)
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors (2019) (7)
Rapid Screening of Antioxidant Anthocyanins in Autochthonous Nero d’Avola Grape Clones by Pre-column DPPH Reaction Coupled to UHPLC-UV/Vis-IT-TOF: a Strategy to Combine Chemical data and Genetic Diversity (2016) (7)
Disulfide bond replacement with 1,4- and 1,5-disubstituted [1,2,3]-triazole on C-X-C chemokine receptor type 4 (CXCR4) peptide ligands: small changes that make big differences. (2020) (7)
Potential Functional Snacks: Date Fruit Bars Supplemented by Different Species of Lactobacillus spp. (2021) (7)
Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids (1994) (7)
Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors. (2021) (7)
A novel β-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA. (2021) (7)
Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals (2020) (6)
Petiodial, a new monocyclic diterpenoid from the Mediterranean green algaUdotea petiolata (1983) (6)
From Protein Communication to Drug Discovery. (2015) (6)
Resveratrol-based Nutraceuticals for the Management of Diabetes and Obesity: Real Therapeutic Potential or a mere Palliative? (2018) (6)
Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold. (2021) (6)
Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies. (2015) (6)
Cyclotides: a natural combinatorial peptide library or a bioactive sequence player? (2015) (6)
Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors. (2006) (6)
13C‐NMR and 1H‐NMR Chemical Shifts in a Correlation Analysis of Benzotriazole Derivatives Active as Plant Growth Regulators (1988) (6)
Unprecedented synthesis of a novel amino quinone ring system via oxidative decarboxylation of quinone-based alpha,alpha-amino esters. (2010) (6)
A Practical Synthesis of 5-Aroyl-1-aryltetrazolesUsing an Ugi-Like 4-Component Reaction Followed by a BiomimeticTransamination (2010) (6)
Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98. (1995) (6)
Abscisic Acid Treatment in Patients with Prediabetes (2020) (6)
Three-dimensional structure of the alpha-MSH-derived candidacidal peptide [Ac-CKPV]2. (2005) (6)
Quantitative structure-activity relationships in a set of thiazolidin -4-ones acting as H1-histamine antagonists. (1995) (6)
Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols. (2014) (6)
A novel route to synthesize Freidinger lactams by micowave irradiation. (2005) (6)
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. (2010) (6)
Conformational analysis of the Gαs protein C‐terminal region (2002) (6)
Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents (2000) (6)
Improved Anti-Prion Nucleic Acid Aptamers by Incorporation of Chemical Modifications. (2020) (6)
Use of Integrated Computational Approaches in the Search for New Therapeutic Agents (2016) (6)
Thinned Nectarines, an Agro-Food Waste with Antidiabetic Potential: HPLC-HESI-MS/MS Phenolic Characterization and In Vitro Evaluation of Their Beneficial Activities (2022) (6)
A structure-activity relationship study on position-2 of the Galpha(s) C-terminal peptide able to inhibit G(s) activation by A2A adenosine receptor. (2003) (6)
Further caulerpenyne-like esters from the green algaCaulerpa prolifera (1983) (5)
Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages (2014) (5)
Novel route in the synthesis of ψ[CH2NH] amide bond surrogate (2008) (5)
Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs (2016) (5)
Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors (2013) (5)
COMBINED USE OF FACTORIAL DESIGN AND COMPARATIVE MOLECULAR FIELD ANALYSIS (COMFA) : A CASE STUDY (1994) (5)
Immunomodulatory activity of Humulus lupulus bitter acids fraction: Enhancement of natural killer cells function by NKp44 activating receptor stimulation (2019) (5)
Application of a Rapid and Simple Technological Process to Increase Levels and Bioccessibility of Free Phenolic Compounds in Annurca Apple Nutraceutical Product (2022) (5)
Ex Vivo Study on the Antioxidant Activity of a Winemaking By-Product Polyphenolic Extract (Taurisolo®) on Human Neutrophils (2021) (5)
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives. (2005) (5)
Beneficial Contribution to Glucose Homeostasis by an Agro-Food Waste Product Rich in Abscisic Acid: Results from a Randomized Controlled Trial (2022) (5)
Native PAGE to study the interaction between the oncosuppressor p53 and its protein ligands (2015) (5)
Sterols of four Mediterranean hydroids (1985) (5)
Antioxidant Properties of Four Commonly Consumed Popular Italian Dishes (2019) (5)
Taurisolo®, a Grape Pomace Polyphenol Nutraceutical Reducing the Levels of Serum Biomarkers Associated With Atherosclerosis (2021) (5)
Investigation of the Stereochemical-Dependent DNA and RNA Binding of Arginine-Based Nucleopeptides (2019) (5)
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. (2011) (5)
α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications (2019) (5)
Geometrically Constrained Analogues of N‐Benzylindolylglyoxylylamides: [1, 2, 4]Triazino[4, 3‐a]benzimidazol‐4(10H)‐one Derivatives as Potential New Ligands at the Benzodiazepine Receptor (2003) (5)
Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands (2017) (5)
A Comparative Study on Phytochemical Fingerprint of Two Diverse Phaseolus vulgaris var. Tondino del Tavo and Cannellino Bio Extracts (2022) (5)
On-water pyrrolidine-mediated domino synthesis of 2-iminoisatins (2018) (5)
Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides (2018) (5)
A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands (2014) (5)
GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis. (2020) (5)
Structure–Activity Relationship Studies, SPR Affinity Characterization, and Conformational Analysis of Peptides That Mimic the HNK‐1 Carbohydrate Epitope (2017) (5)
Biomimetic Synthesis of 5,6-Dihydroxyindole-2-Carboxylic Acid and of its Benzyl Ester (1987) (4)
Optimization of Phlorizin Extraction from Annurca Apple Tree Leaves Using Response Surface Methodology (2022) (4)
Synthesis of new pyrido(4,3- g and 3,4-g)quinoline-5,10-dione and dihydrothieno(2,3-g and 3,2-g)quinoline-4,9-dione derivatives and preliminary evaluation of cytotoxic activity (2004) (4)
Preparation of Constrained Unnatural Aromatic Amino Acids via Unsaturated Diketopiperazine Intermediate (2016) (4)
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald–Hartwig intramolecular cyclization (2016) (4)
Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors. (2019) (4)
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase (2021) (4)
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor. (2018) (4)
An antibody-free strategy for screening putative HDM2 inhibitors using crude bacterial lysates expressing GST-HDM2 recombinant protein. (2013) (4)
Synthesis and antiinflammatory—analgesic profile of 1-methyl-2-(4-X-benzoyl) imidazole-5-carboxylic acids (1995) (4)
Two New Polyoxygenated Sterols from the Marine Hydroid Eudendrium glomeratum (1985) (4)
Novel Cyclic Biphalin Analogues by Ruthenium-Catalyzed Ring Closing Metathesis: in Vivo and in Vitro Biological Profile. (2019) (4)
Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at Cα of selected amino acids (2017) (4)
Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors. (2021) (4)
Arylthiopyrrole (AThP) Derivatives as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors: Synthesis, Structure–Activity Relationships, and Docking Studies (Part 1) (2006) (4)
In vitro Bioaccessibility, Bioavailability, and Plasma Protein Interaction of New Oral Anticoagulants in the Presence of Macronutrients. (2019) (4)
A Food-Grade Method for Enhancing the Levels of Low Molecular Weight Proanthocyanidins with Potentially High Intestinal Bioavailability (2022) (4)
From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair. (2012) (4)
Cold pressed argan (Argania spinose) oil (2020) (4)
In vitro effects of protein fractions from Controne beans (Phaseolus vulgaris L. ecotype Controne) on intestinal permeability, ACE and α-amylase activities (2019) (4)
Inside Cover: Identification of Structural Features of 2‐Alkylidene‐1,3‐Dicarbonyl Derivatives that Induce Inhibition and/or Activation of Histone Acetyltransferases KAT3B/p300 and KAT2B/PCAF (ChemMedChem 1/2015) (2015) (4)
Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “AMES”? (2022) (4)
Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary Cirrhosis. (2015) (4)
Synthetic Strategies for Aspartic and Glutamic Acid-Proline Chimeras: A Review (2015) (4)
2-Amino-6-[(1'R,2'S)-1',2'-dihydroxypropyl]-3-methyl-pterin-4-one, a biologically active metabolite from the anthozoanAstroides calycularis Pallas (1987) (4)
Site‐directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non‐Nucleoside Inhibitors (2016) (4)
Cardioprotective Effects of Taurisolo® in Cardiomyoblast H9c2 Cells under High-Glucose and Trimethylamine N-Oxide Treatment via De Novo Sphingolipid Synthesis (2020) (4)
p 53 Functional Inhibitors Behaving Like Pi fi thrin ‐ β Counteract the Alzheimer Peptide Non-β-amyloid Component E ff ects in Human SH-SY 5 Y Cells (2014) (3)
Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca2+/Calmoduline-Dependent Protein Kinase II (2010) (3)
A fast route for the synthesis of tetrazolyl oximes by a novel multicomponent reaction between Z-chlorooximes, isocyanides and trimethylsilyl azide (2017) (3)
Design and synthesis of melanocortin peptides with candidacidal and anti-TNF-alpha properties. (2005) (3)
Studies of membranotropic and fusogenic activity of two putative HCV fusion peptides. (2019) (3)
Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study (2019) (3)
Design and synthesis of small libraries of peptidomimetics based on a thiazolidine moiety (2006) (3)
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases. (2019) (3)
Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6- Arylpyrrolo(2,1-d) (1,5)benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. (1994) (3)
Synthesis and Pharmacological Evaluation of Potent and Highly Selective D3 Receptor Ligands: Inhibition of Cocaine-Seeking Behavior and the Role of (2003) (3)
New results on the reactivity of 5,6-diamino-4-hydroxy- 2-mercaptopyrimidine (2004) (3)
HOPPI-NMR: Hot-Peptide-Based Screening Assay for Inhibitors of Protein-Protein Interactions by NMR. (2020) (3)
DOTA-Derivatives of Octreotide Dicarba-Analogs with High Affinity for Somatostatin sst2,5 Receptors (2017) (3)
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents (2018) (3)
Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds (2020) (3)
Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives. (2011) (3)
Nutraceuticals Food Supplements and Cholesterol Level Control (2017) (3)
Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis (2014) (3)
Nondenaturing polyacrylamide gel electrophoresis to study the dissociation of the p53·MDM2/X complex by potentially anticancer compounds (2015) (3)
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines (2019) (3)
Gαs protein C‐terminal α‐helix at the interface: does the plasma membrane play a critical role in the Gαs protein functionality? (2005) (3)
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand (2021) (3)
1. Bertini, I., Luchinat, C., Parigi, G., and Ravera, E., SedNMR: on the edge between solution and solid state NMR, Acc.Chem.Res., 2013, Epub ahead of print (IF 21.640). (2013) (3)
Structure–Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9 (2016) (3)
Unusual reaction of a substituted benzothiazoline with sulphuryl chloride: formation of a 2,2′-(ethane-1,2-diylidene)bis-1,4-benzothiazine dye (1977) (3)
Cover Picture: Ensemble‐Docking Approach on BACE‐1: Pharmacophore Perception and Guidelines for Drug Design (ChemMedChem 5/2007) (2007) (3)
Online comprehensive hydrophilic interaction chromatography × reversed phase liquid chromatography coupled to mass spectrometry for in depth peptidomic profile of microalgae gastro-intestinal digests. (2019) (3)
Benzodiazepine Scaffold as Drug-like Molecular Simplification of FR235222: A Chemical Tool for Exploring HDAC Inhibition. (2016) (2)
Identification of novel β‐secretase inhibitors through the inclusion of protein flexibility in virtual screening calculations (2008) (2)
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at the indole-2-carboxamide (2011) (2)
Synthesis of conformationally constrained β-turn thiazolidine mimetic (2002) (2)
Galphas protein C-terminal alpha-helix at the interface: does the plasma membrane play a critical role in the Galphas protein functionality? (2005) (2)
Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides (2020) (2)
Ensemble‐Docking Approach on BACE‐1: Pharmacophore Perception and Guidelines for Drug Design (2007) (2)
Synthesis of Quinolindione Derivatives Assisted by Microwave Irradiation (2005) (2)
Synthesis of 3-phenyl-2H-1,4-benzoxazin-2-one. Revision of some structural assignments (1977) (2)
Lipidated peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as biased allosteric ligands (2021) (2)
Bioactive Compounds for the Management of Hypertriglyceridemia: Evidence From Clinical Trials and Putative Action Targets (2020) (2)
Human integrin alphavbeta5: homology modeling and ligand binding. (2004) (2)
CHOLEST-5-ENE-2α,3α,7β,15β,18-PENTOL 2,7,15,18-TETRAACETATE, A NOVEL HIGHLY HYDROXYLATED STEROL FROM THE MARINE HYDROID EUDENDRIUM GLOMERATUM (1985) (2)
Use of the Hydrophobic Substituent Constant in a Comparative Molecular Field Analysis (CoMFA) on a Set of Anilides Inhibiting the Hill Reaction (1993) (2)
Synthesis of Dihydroplakortin (2010) (2)
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: A mild access to N-substituted α-amino acid amides (2018) (2)
Reversible formation of cyclic 1,4-benzothiazine oligomers (1987) (2)
Design, Synthesis and Conformational Analysis of Human Urotensin II (U-II) Analogues with Lactam Bridge (2001) (2)
A Practical Synthesis of 5‐Aroyl‐1‐aryltetrazoles Using an Ugi‐Like 4‐Component Reaction Followed by a Biomimetic Transamination. (2011) (2)
Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes (2021) (2)
Chemical behaviour of 1,4-benzoxazine† (1980) (2)
UROTENSIN II RECEPTOR IS INVOLVED IN THE REGULATION OF MOTILITY OF PROSTATE ADENOCARCINOMA CELLS AND PREDICTS THE CLINICAL OUTCOME OF PROSTATE CANCER PATIENTS (2010) (1)
Indolylarylsulfones Bearing Natural and Unnatural Amino Acids as Potent HIV-1 NNRTIs. (2009) (1)
Properly Substituted Cyclic Bis-(2-bromobenzylidene) Compounds Behaved as Dual p300/CARM1 Inhibitors and Induced Apoptosis in Cancer Cells (2020) (1)
Receptors: Design, Synthesis, and Effects on Behavior (2009) (1)
Corrigendum to “Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors” [Eur. J. Pharmacol. 477 (2003) 227–234] (2004) (1)
The economic impact of biosimilars in Italy: a scenario analysis (2019) (1)
Recent trends and advances in food chemistry and analysis: research highlights from the IX Italian Congress of Food Chemistry. (2013) (1)
Tandem solid phase peptide synthesis and microwave-assisted reaction to perform macrocyclization reactions (2003) (1)
Thiazolidin‐4‐one Formation. Mechanistic and Synthetic Aspects of the Reaction of Imines and Mercaptoacetic Acid under Microwave and Conventional Heating. (2005) (1)
Design, Synthesis, Biological Activity, and Structural Analysis of Lactam‐Constrained PTPRJ Agonist Peptides (2018) (1)
Optimization of Ursolic Acid Extraction in Oil from Annurca Apple to Obtain Oleolytes with Potential Cosmeceutical Application (2023) (1)
Synthetic studies toward bicyclic endoperoxides presenting polar side chains (2018) (1)
Investigation on side-product formation during the synthesis of a lactoferrin-derived lactam-bridged cyclic peptide (2018) (1)
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory. (2021) (1)
A Practical, Green, and Selective Approach Toward the Synthesis of Pharmacologically Important Quinone-Containing Heterocyclic Systems Using Alumina-Catalyzed Michael Addition Reaction. (2008) (1)
Effect of Annurca Apple Polyphenols on Intermittent Claudication in Patients With Peripheral Artery Disease. (2019) (1)
Modification of the potent peptide FK888 with unusual aminoacids: effects on activity on neurokinin receptors. (1996) (1)
Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion (2014) (1)
Benzotriazole Derivatives Active on Plant Growth: Design, Synthesis, and Physicochemical Properties. (1988) (1)
Synthesis, in vivo pharmacological evaluation and pharmacokinetic studies of N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide cannabinoid receptor ligands. (2010) (1)
Indole derivatives as probes to study the benzodiazepine binding site in GABA receptor complex. (1996) (1)
Erratum: Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant (Journal of Medicinal Chemistry (2006) 49, (5840)) (2006) (1)
Uratensin-II receptor: A new diagnostic marker and therapeutic target in human prostate adenocarinoma (2007) (1)
A Stereoselective Route to 6‐Substituted Pyrrolo‐1,5‐benzoxazepinones and Their Analogues. (2014) (1)
Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections (2023) (1)
Synthesis of Aminocarbonyl N‐Acylhydrazones by a Three‐Component Reaction of Isocyanides, Hydrazonoyl Chlorides, and Carboxylic Acids. (2015) (1)
DOP66 A CEACAM5 small peptide restores the suppressive activity of CD8 + T cells in patients with Crohn’s disease (2020) (1)
Exploiting the pyrazolo[3,4-d]pyrimidinone ring system as a useful template for the obtainment of potent adenosine deaminase inhibitors (2008) (0)
Folding intermediate states of the parallel human telomeric G-quadruplex DNA explored using Well-Tempered Metadynamics (2020) (0)
Discovery of a new subnanomolar Tumor Necrosis Factor-alpha Converting Enzyme (TACE) inhibitor as antiinvasive agent (2009) (0)
Synthesis and biological evaluation on human glioblastoma cells of novel pyrazolo3,4-Dpyrimidine adenosine A3 receptor antagonists (2009) (0)
Drug Design of New NS3/4A HCV Serine Protease Inhibitors. Structure-Based and Ligand-Based Approaches. (2009) (0)
NMR structure analysis of the Penetratin conjugated Gas (374-394) peptide (2007) (0)
Novel Peptidomimetic as MMP-2 Inhibitors (2007) (0)
Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor. (1995) (0)
Molecular Modeling Studies of Arylthioindoles and Related Bioisosteres, Potent Inhibitors of Tubulin Polymerization. (2009) (0)
University of Groningen Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease Skronska-Wasek, (2017) (0)
Shooting for selective drug-like DNA G-quadruplex binders (2012) (0)
Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking (2014) (0)
Towards an analytical methodology for the screening of G-quadruplex-binding ligands (2013) (0)
Rational Design and Synthesis of Potent and Selective Adenosine Receptor Antagonists (2009) (0)
NMR structure of peptide 7, characterized by a cis-4-amino-Pro residue, with a significant lower MIC on E. coli (2019) (0)
Synthesis and Antimicrobial Activities of 5-Amidobenzotriazole Derivatives. (1990) (0)
Fluorescence enhancement in G-quadruplex folding: Synthesis, structure and stability of a novel dansyl-tagged, conjugated TBA (2012) (0)
Correction to "Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease". (2019) (0)
First venting while heating microwave-assisted synthesis of 3-arylthioindoles as potent Inhibitors of tubulin polymerization. (2012) (0)
Synthesis and antimicrobiological evaluation of Temporin A analogues substituted with L-alanine. (2010) (0)
New Results on the Reactivity of 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine. (2005) (0)
P141 Annurca apple extracts in treatment of children's hypercholesterolemia: double-blind placebo-controlled cross-over randomized study (2018) (0)
New Pyrrolobenzothiazepine Derivatives as Molecular Probes of the “ Peripheral-Type” Benzodiazepine Receptor (PBR) Binding Site. (1997) (0)
Synthesis of 3-(2'-furoyl)indole derivatives as potential new ligands at the benzodiazepine receptor, structurally more restrained analogues of indoleglyoxylylamides. (1995) (0)
Validation of an LC-MS/MS Method for the Determination of Abscisic Acid Concentration in a Real-World Setting (2023) (0)
High-throughput drug screening by Printing Biology (2015) (0)
2-PHENYL[1,2,3]TRIAZOLO[1,2-a]BENZOTRIAZIN-1-ONE DERIVATIVES AS A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS (2005) (0)
Increased Levels of Circulating Iron-Albumin Complexes in Peripheral Arterial Disease Patients (2023) (0)
Synthesis and muscarinic receptor binding profiles of antagonist benzotriazole derivatives. (1993) (0)
Synthesis and biological evaluation of Modified 2-Phenylindol-3-ylglyoxylamides as good candidates for the development of radioligands for the visualization of peripheral benzodiazepine receptor (2007) (0)
Microwave-assisted synthesis of KN-62, KN-92 and KN-93 as pharmacological tools for Ca2+/calmodulin-dependent protein kinase II (CAMK II) activity investigation (2008) (0)
The mesenchymal stem cell differentiation to osteoblasts is potentiate by the allosteric modulation of A2B adenosine receptors. (2015) (0)
Molecular Underpinnings of MMP-13 Selective Inhibition by Arylsulfonamido Hydroxamate Analogues as Potential Therapeutic Agents in Osteoarthritis (2009) (0)
A combined cell based and site directed mutagenesis approach defines highly conserved residues involved in the selective inhibition of the HIV-1 ribonuclease H function by diketoacid derivatives (2014) (0)
NMR structure of Urotensin Peptide Asp-c[Cys-Phe-(N-Me)Trp-Lys-Tyr-Cys]-Val in SDS solution (2019) (0)
Antitumoral effect by induction of collapse of mitochondrial membrane potential in Glioblastoma Multiforme cells (2012) (0)
Amyloidogenicity of regions of Nucleophosmin 1: a direct link between protein misfolding and Acute Myeloid Leukemia (2018) (0)
Indolyl Aryl Sulfones with aminoacid units as potent HIV-1 NNRTIs. (2008) (0)
Novel Antitumoral Pyrazolopyrimidines Based on Inhibition of Protein Tyrosine Kinase (2007) (0)
Docking and Molecular Dynamics Studies of Arylthioindoles. (2008) (0)
Conformational analysis of furanoid epsilon-sugar amino acid containing cyclic peptides by NMR spectroscopy, molecular dynamics simulation, and X-ray crystallography: evidence for a novel turn structure. (2003) (0)
Design, Synthesis, and Evaluation of Gluten Peptide Analogs as Selective Inhibitors of Human TG2 (2006) (0)
Peptide Agonists and Antagonists with Potential Application in Neurological Disorders. (2016) (0)
Reversible Formation of Cyclic 1,4-Benzothiazine Oligomers. (1988) (0)
3D-QSAR and virtual screening studies for the translocator protein(TSPO) (2008) (0)
NMR structure of Peptide PG-989 in DPC micelles (2015) (0)
Translocator protein (tspo) ligand residence time: a new parameter to predict neurosteroidogenic efficacy for n,n-dialkyl-2-arylindol-3-ylglyoxylamides (PIGAs) (2016) (0)
Novel Pyrazolopyrimidine Derivatives as Therapeutic Agents for the Treatment of Medullary Thyroid Carcinoma (2011) (0)
New Urotensin-II Analogs Modified at Position 4 (2006) (0)
Carboxyl-Terminal Peptide Prevents Gs Activation by the A 2 A Adenosine Receptor (2000) (0)
Urotensin-II Receptor Regulates Cell Mobility/Invasion and Determines Prognosis of Bladder Cancer (2013) (0)
Continuous-flow synthesis of thiazolidine libraries:one-pot two steps protocol optimization (2015) (0)
Solution structure of the G-triplex truncated-TBA (2014) (0)
342 TMAO PLASMA LEVELS PREDICT RECURRENT ISCHEMIC EVENTS IN SURVIVORS OF MYOCARDIAL INFARCTION (2022) (0)
Response to Keith et al. Re: "Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial". (2019) (0)
Progress in the development of arylthioindoles, potent inhibitors of tubulin polymerization and MCF-7 cell growth. (2008) (0)
Tubulin-6j complex (2018) (0)
Reactivation of p53 by inhibition of interaction with its natural inhibitor MDM2 in glioblastoma multiforme cells (2013) (0)
Arylthioindole Bioisosteres as Potent Tubulin Polymerization and MCF-7 Cell Growth Inhibitors (2009) (0)
Synthesis and Biological Activity of Benzotriazole Derivatives Structurally Related to Trazodone. (1995) (0)
Correction to new anticancer agents mimicking protein recognition motifs. (2015) (0)
NMR structure of Peptide PG-992 in DPC micelles (2015) (0)
Aromatase Inhibitors: Comparison between a CoMFA Model and the Enzyme Active Site (2000) (0)
COMPUTATIONAL INVESTIGATION ON SUBSTRATE UPTAKE AND RELEASE IN A GLUTAMATE TRANSPORTER (2012) (0)
Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties. (2023) (0)
Cover Picture: Breaking the Dogma of the Metal‐Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity (Angew. Chem. Int. Ed. 24/2009) (2009) (0)
Indolylarylsulfones Bearing Natural and Unnatural Amino Acids are Potent HIV-1 Reverse Transcriptase and Coxsackie B4 Virus Non-Nucleoside Inhibitors. (2009) (0)
Pyrazolo[3,4,-d]pyrimidine-4-one Derivatives as Novel and Potent Inhibitors of Adenosine Deaminase (2007) (0)
Novel peptidomimetic as MMP2 inhibitors (2007) (0)
Characterization of two synthetic ligands of peroxisome proliferator‐activated receptor γ (PPARγ) by cofactor recruitment, site‐directed mutagenesis and structure analysis (2010) (0)
Suitable Scaffolds for the Development of Noncamptothecin Topoisomerase I (Top1) Inhibitors (2014) (0)
Inhibition of Metalloproteinases in Vitro Activity and Arrest of Invasion in Human Glioblastoma Cells (2010) (0)
Identification of novel dual Peroxisome Proliferator‐Activated Receptor α/γ ligands and characterization of their biochemical properties by 3D structural studies (2006) (0)
ChemInform Abstract: Cycloaddition Reactions of Thiazolidine Derivatives. An Approach to the Synthesis of New Functionalized Heterocyclic Systems. (2002) (0)
Urotensin-II Receptor Peptide Agonists (2004) (0)
5HT1a Receptor Binding Affinities of a Series of Serotonin Transporter (SERT) Inhibitors and Related Thermodynamic Insights (2015) (0)
Glioblastoma multiforme: induction of mitochondria-mediated apoptotic pathway by simultaneous pharmacological activation of TSPO (18KDa) and p53. (2013) (0)
Pepducin UT-Pep2 a biased allosteric agonist of Urotensin-II receptor (2019) (0)
Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86) (2012) (0)
New 2-Heterocyclil-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors (2012) (0)
Targeting the Translocator protein (TSPO) with 2-phenylindol-3-ylglyoxylamide derivatives (2009) (0)
CCDC 786882: Experimental Crystal Structure Determination (2010) (0)
Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands (2020) (0)
A Convenient One Step Synthesis of 5-Cystein-S-yldopa Using Ceric Ammonium Nitrate. (1987) (0)
New Urotensin-II Analogs with a Constrained Trp-7 Side Chain (2006) (0)
N,N-dialkyl-2-phenylindol-3-ylglyoxylylamide derivatives: a new class of potent and selective "pheripheral-type" benzodiazepine receptor ligands (2003) (0)
UNUSUAL REACTION OF A SUBSTITUTED BENZOTHIAZOLINE WITH SULFURYL CHLORIDE‐ FORMATION OF A 2,2′‐(ETHANE‐1,2‐DIYLIDENE)BIS‐1,4‐BENZOTHIAZINE DYE (1978) (0)
Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors (2017) (0)
Refinement of Structure-activity Relationships of the Triazinobenzimidazole A1AR Antagonists (2007) (0)
Design, Synthesis, and Biological Evaluation of 3-Arylindazole Acetic Acid Derivatives as Aldose Reductase Inhibitors (2007) (0)
Crystal structure of the complex between PPAR-gamma and the agonist LT248 (clofibric acid analogue) (2008) (0)
Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid (2009) (0)
Molecular modelling studies with CCK-B receptor antagonists (1993) (0)
NMR solution structure of the 4:1 complex between an uncharged distamycin A analogue and [d(TGGGGT)]4 (2010) (0)
Design, Synthesis and Biological Evaluation of Novel 2-(N-Aryl or Heteroarylphenylsulfonamido)acetic Acids as Aldose Reductase Inhibitors (2009) (0)
RING EXPANSION OF BENZOTHIAZOLINES INTO 1,4-BENZOTHIAZINES (1977) (0)
Combinatorial Approach in the Synthesis of a Small Library of β-Turn Structures Based on Thiazolidine Moiety (2006) (0)
A regioselective approach toward the synthesis of pharmacologically important quinone-containing heterocyclic systems (2009) (0)
Computer aided drug design approach in the development of PKnB inhibitors as potential antimycobacterial agents. (2012) (0)
On resin click-chemistry-mediated synthesis of novel enkephalin analogues with potent anti-nociceptive activity (2019) (0)
We-P11:119 3D structure and biological activity of novel dual peroxisome proliferator-activated receptors alpha/gamma ligands (2006) (0)
Inside Cover: Looking for Efficient G-Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug-Like Molecules (ChemMedChem 4/2015) (2015) (0)
Allosteric modulation of A2B adenosine receptors potentiate the effects of orthosteric receptor agonists to promote mesenchymal stem cell differentiation to osteoblasts. (2013) (0)
Enantioselective properties of Penicillin G Acylase: Liquid Crhomatographic studies end docking simulations (2005) (0)
Arylthioindoles: Design, Synthesis and Biological Activity (2007) (0)
Multicomponent Reaction of Z‐Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One‐Pot Route to Aminodioximes and Their Transformation into 5‐Amino‐1,2,4‐oxadiazoles by Mitsunobu—Beckmann Rearrangement. (2016) (0)
Biomimetic Synthesis of 5,6-Dihydroxyindole-2-carboxylic Acid and of Its Benzyl Ester. (1988) (0)
Crystal structures of two trimers of 1,4-benzothiazine (1989) (0)
Interactions of cisplatin analogues with lysozyme: a comparative analysis (2017) (0)
Glycosylated derivatives of N omega-nitro-L-arginine for use as anti-tumor agents (2007) (0)
Novel Anti-HIV agents targeted to the HIV-1 Reverse Transcriptase associated Ribonuclease H function: Quinolonyl Acid and 5,6-Dihidroxybenzopyranone derivatives (2012) (0)
New α-(N)-Heterocyclichydrazones: Evaluation of Anticancer, anti-HIV, and Antimicrobial Activity. (2004) (0)
Identification of novel dual Peroxisome Proliferator-Activated Receptor alpha/gamma ligands and characterization of their biochemical properties by 3D structural studies (2006) (0)
New Indolylarylsulfones as Potent and Broad Spectrum HIV‐1 Non-Nucleoside Reverse Transcriptase Inhibitors. II. (2014) (0)
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties (2010) (0)
Investigation on side-product formation during the synthesis of a lactoferrin-derived lactam-bridged cyclic peptide (2018) (0)
Synthesis and Antiinflammatory-Analgesic Profile of 1-Methyl-2-(4-X- benzoyl)imidazole-5-carboxylic Acids (1995) (0)
Efficient Synthesis in Solid-Phase of Freidinger-like Lactams by Microwave Irradiation (2006) (0)
Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid. (2005) (0)
clic endoperoxides : new antimalarial sca ff olds † (2015) (0)
Synthesis and biological evaluation of delta2-isoxazoline derivatives as DNA methyltransferase 1 (DNMT1) inhibitors (2015) (0)
Green Tea Composition : “ Fig . 3 ” : Composition of Tea Catechin mode of action : 1 (2022) (0)
Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops (2018) (0)
Cover Picture: tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells (ChemMedChem 5/2013) (2013) (0)
Reaction Between (Z)‐Arylchlorooximes and α‐Isocyanoacetamides: A Procedure for the Synthesis of Aryl‐α‐ketoamide Amides. (2015) (0)
A Round Trip from Medicinal Chemistry to Predictive Toxicology. (2016) (0)
CHEMICAL BEHAVIOR OF 1,4-BENZOXAZINE (1980) (0)
On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives. (1989) (0)
Facile Baeyer-Villiger Oxidation of Cyclic Ketones: Conventional versus Microwave-Assisted Approach. (2016) (0)
Asymmetrically Substituted N,N-dialkyl-2-phenylindol-3-ylglyoxylamides as Topological Probes to Explore the L3 and L4 Lipophilic Regions of the Peripheral Benzodiazepine Receptor Site (2005) (0)
Design, synthesis, and biological evaluation of novel fluorescent probes targeting the Translocator Protein (18 kDa) (TSPO) (2009) (0)
HIV-1 Integrase and Ribonuclease H inhibition by pyrrolyl diketohexenoic acids derivatives (2012) (0)
An Efficient Synthesis of 1‐Arylindazole‐3‐carboxamides Using Nitrile Imines, Isocyanides and 2‐Hydroxymethylbenzoic Acid, Followed by a Chemoselective Buchwald—Hartwig Intramolecular Cyclization. (2016) (0)
Benzo[d]isothiazoles and Matrix Metalloproteinases. Searching for Novel and Selective Inhibitors of MMP9 (2008) (0)
NMR structure of peptide 10 targeting CXCR4 (2016) (0)
A New Efficient Synthetic Methodology for Tetrahydroisoquinoline and Tetrahydro-β-carboline Derivatives Using the Pictet—Spengler Reaction. (2005) (0)
Substituted 2-Arylindolglyoxylamides as Potent Translocator Protein (18 kDa) TSPO ligands: Synthesis and Biological Evaluation (2009) (0)
Molecular modeling of the urotensin-ut receptor complex (2004) (0)
Synthesis and Pharmacological Evaluation of Some 4-Oxo-quinolin-2-carboxylic Acid Derivatives as Antiinflammatory and Analgesic Agents. (2011) (0)
FROM GARCINOL TO BARBITURIC ACID DERIVATIVES: DEVELOPMENT OF NEW AND SELECTIVE P300 INHIBITORS. (2014) (0)
Conformational studies on three synthetic C-terminal fragments of the α subunit of a Gs protein (2002) (0)
Tubulin polymerization and mitochondrial potential: a link under exploration (2012) (0)
Effects of physical exercise associated with a diet enriched with natural antioxidants on cerebral hypoperfusion and reperfusion injury in spontaneously hypertensive rats (2023) (0)
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Aza-tanshinones as novel, effective HuR Inhibitors (2021) (0)
Design and synthesis of a novel irreversible fluorescent ligand for the visualization of Translocator Protein (18kDa) (2009) (0)
Synthesis, biological evaluation and molecular modeling investigation of fibrates analogues with PPARalpha945; and PPARgamma47; agonist activity (2008) (0)
Free protein amino acids of some Mediterranean Siphonales (1984) (0)
Regulation of gene expression in the liver and adipose tissue by a new dual PPAR alpha/gamma Agonist (2009) (0)
High-throughput screening at the picoliter scale by combining Dip Pen Lithography with Inkjet printing (2015) (0)
NOVEL KINASE INHIBITORS IN THYROID CANCER TREATMENT: SYNTHESIS AND BIOLOGICAL EVALUATION (2012) (0)
P.08.6 UROTENSIN-II RECEPTOR: A NEW MARKER FOR THE DIFFERENTIATION AND THE TARGET IN COLON CANCER? (2012) (0)
Studies in search for selective ligands for GABAA/BzR receptor subtypes: synthesis and biological evaluation of 4'-modified N-(benzyl)indol-3-ylglyoxylamides (2005) (0)
Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer) (2008) (0)
Phoenix dactylifera polyphenols improve plasma lipid profile in hyperlipidemic rats and oxidative stress on HepG2 cells (2021) (0)
Synthesis of N-Methyl and Azasulfuryl Urotensin-II(4-11) Derivatives (2015) (0)
NEW APPROACHES IN THE TREATMENT OF GLIOBLASTOMA USING A LOW DOSAGE OF MATRIX-METALLOPROTEINASE INHIBITORS (2010) (0)
Glioblastoma multiforme: antitumoral in vitro effect by induction of collapse of mitochondrial membrane potential (2012) (0)
Effects of variable sampling on COMFA coefficient contour maps (1994) (0)
SAR Study on CN17β a Potent and Selective CaMKII Peptide Inhibitor (2013) (0)
Ensemble-docking approach on BACE-1: Pharmacophore Perception and Directives for Drug Development (2007) (0)
Structural and biological studies of a penetratin linked G alpha(s) C-terminal peptide (2003) (0)
Allosteric modulation of A2B adenosine receptors favours mesenchymal stem cell differentiation to osteoblasts. (2014) (0)
Design,Synthesis and Biological Evaluation of New 4-Thiazolidinone Derivatives in Breast Cancer Cells (2012) (0)
A cell-penetrating peptide combined with the G alpha(s) C-terminal sequence as inhibitor of A(2A) adenosine receptor signaling in PC12 cells (2005) (0)
A New Approach to the Synthesis of Policyclic Dipeptide Derivatives as Potential Antitumoral Agents (2006) (0)
NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa. (2019) (0)
Genotoxicity Assessment of Nutraceuticals Extracted from Thinned Nectarine (Prunus persica L.) and Grape Seed (Vitis vinifera L.) Waste Biomass (2023) (0)
Indolylarylsulfones bearing natural and unnatural amino acids as inhibitors of HIV-1 reverse transcriptase and Coxsackie B4 virus. (2010) (0)
Some New Aspects on the Chemistry of 1,4-Benzoxazines. (1986) (0)
Template for the Design of Highly Selective A 2 B Adenosine Receptor Antagonists (2012) (0)
A Crosstalk between Melatonin and Taste-Receptors’ Signaling Tunes Quinine-Induced Gut Hormone Secretion in Mice (2018) (0)
Crystal structure of PPARgamma with the ligand FS214 (2013) (0)
3-Aroyl-1-arylpyrroles: a New Class of Potent Inhibitors of Tubulin Polymerization. (2014) (0)
Design, Synthesis, and Conformational Analysis of Melanotropin Analogues of MTII and SHU9119 (2013) (0)
Design and synthesis of novel metalloproteinases inhibitors (2009) (0)
NMR Structure of Peptide PG-990 in DPC micelles (2015) (0)

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What Schools Are Affiliated With Ettore Novellino?

Ettore Novellino is affiliated with the following schools:

University of Catania
Consorzio ICoN
University of Milan
University of Salerno
Cardiff University
University of Siena
University of Padua
University of Florence
University of Naples Federico II
Technical University of Munich
Università Cattolica del Sacro Cuore
University of Bologna