Eva-Maria Mandelkow
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Alzheimer's researcher
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(Suggest an Edit or Addition)According to Wikipedia, Eva-Maria Mandelkow is a German neuroscientist and Alzheimer's disease researcher at the German Center for Neurodegenerative Diseases , Bonn. Biography Eva-Maria Mandelkow studied medicine in Hamburg and Heidelberg, qualifying in 1968. After three years of medical internships, she began doctoral studies at the Max Planck Institute for Medical Research, Heidelberg, investigating the enzyme kinetics of the motor protein myosin. She graduated in 1973 with a Ph.D. in biochemistry, then undertook postdoctoral training at Brandeis University in Massachusetts researching cytoskeletal proteins. She continued to work in this area after returning to the Max Planck Institute in Heidelberg as a staff scientist . In 1986 she moved with her husband and colleague, , to lead research teams at the located within the DESY facility, Hamburg. Since 2011 Eva-Maria and Eckhard Mandelow have led closely aligned research teams at DZNE.
Eva-Maria Mandelkow's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- Tau in Alzheimer's disease. (1998) (905)
- MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption (1997) (827)
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
- Biochemistry and cell biology of tau protein in neurofibrillary degeneration. (2012) (660)
- Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? (2001) (606)
- Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease (2014) (604)
- Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines (2010) (593)
- Microtubule dynamics and microtubule caps: a time-resolved cryo- electron microscopy study (1991) (539)
- Microtubules and microtubule-associated proteins. (1995) (526)
- Microtubules and microtubule-associated proteins. (1995) (526)
- Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure. (1994) (523)
- Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009) (522)
- A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads (2004) (521)
- Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure* (2001) (469)
- The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region. (1992) (456)
- Neuronal activity regulates extracellular tau in vivo (2014) (418)
- The release and trans-synaptic transmission of Tau via exosomes (2017) (411)
- Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses (2003) (401)
- Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses (2003) (401)
- Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. (2000) (371)
- MAPs, MARKs and microtubule dynamics. (1998) (348)
- Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. (2000) (338)
- Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy (2006) (334)
- In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice (2011) (310)
- Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark) (1995) (309)
- Missorting of Tau in Neurons Causes Degeneration of Synapses That Can Be Rescued by the Kinase MARK2/Par-1 (2007) (286)
- Phosphorylation of microtubule‐associated protein tau: identification of the site for Ca2(+)‐calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. (1990) (278)
- Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant (2011) (276)
- The Potential for β-Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy (2008) (275)
- Single‐molecule investigation of the interference between kinesin, tau and MAP2c (2002) (251)
- Autophagic degradation of tau in primary neurons and its enhancement by trehalose (2012) (248)
- A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. (2009) (247)
- Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease (2007) (224)
- What is the evidence that tau pathology spreads through prion-like propagation? (2017) (221)
- Development of tau aggregation inhibitors for Alzheimer's disease. (2009) (216)
- Tubulin domains probed by limited proteolysis and subunit-specific antibodies. (1985) (212)
- Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. (2012) (208)
- Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation* (2008) (207)
- The tau of MARK: a polarized view of the cytoskeleton. (2009) (206)
- Amyloid‐β oligomers induce synaptic damage via Tau‐dependent microtubule severing by TTLL6 and spastin (2013) (201)
- Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration (2011) (173)
- Tau protein and tau aggregation inhibitors (2010) (164)
- A mechanistic model of tau amyloid aggregation based on direct observation of oligomers (2015) (158)
- Recombinant kinesin motor domain binds to beta-tubulin and decorates microtubules with a B surface lattice. (1993) (156)
- The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy* (2007) (155)
- The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. (1999) (149)
- Rhodanine-based tau aggregation inhibitors in cell models of tauopathy. (2007) (147)
- Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. (2012) (144)
- Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology* (2013) (141)
- On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness (1986) (139)
- On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness (1986) (139)
- Atypical, non-standard functions of the microtubule associated Tau protein (2017) (138)
- Tau as a marker for Alzheimer's disease. (1993) (130)
- Tau as a marker for Alzheimer's disease. (1993) (130)
- Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly. (1985) (129)
- Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly. (1985) (129)
- Kinesin motors and disease. (2002) (127)
- Proteolytic processing of tau. (2010) (126)
- Interplay of pathogenic forms of human tau with different autophagic pathways (2017) (125)
- Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells. (2007) (118)
- Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau (2012) (114)
- Oligomer Formation of Tau Protein Hyperphosphorylated in Cells* (2014) (112)
- Tau: From research to clinical development (2016) (108)
- Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease (2001) (108)
- Accurate Balance of the Polarity Kinase MARK2/Par-1 Is Required for Proper Cortical Neuronal Migration (2008) (108)
- A new look at the microtubule binding patterns of dimeric kinesins. (2000) (107)
- The anatomy of flagellar microtubules: polarity, seam, junctions, and lattice (1995) (106)
- Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment (2011) (105)
- Regulation of Alternative Splicing of Human Tau Exon 10 by Phosphorylation of Splicing Factors (2001) (104)
- Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau (2015) (102)
- S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila (2007) (101)
- Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability* (2010) (101)
- Alzheimer's disease: The tangled tale of tau (1999) (100)
- Structure and function of polarity‐inducing kinase family MARK/Par‐1 within the branch of AMPK/Snf1‐related kinases (2010) (100)
- Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells. (1995) (95)
- Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules (2001) (91)
- Microtubule‐Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study (2000) (87)
- The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity (2016) (86)
- Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation (2010) (86)
- Tubulin domains responsible for assembly of dimers and protofilaments. (1985) (85)
- Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease (1999) (85)
- X-ray kinetic studies of microtubule assembly using synchrotron radiation (1980) (84)
- Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid‐β Peptides (2006) (83)
- Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. (2006) (81)
- Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture (2017) (81)
- Linking Amyloid-β and Tau: Amyloid-β Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton (2011) (79)
- Dynamics and cooperativity of microtubule decoration by the motor protein kinesin. (2001) (78)
- Spatial patterns from oscillating microtubules. (1989) (77)
- Spatial patterns from oscillating microtubules. (1989) (77)
- Screening for inhibitors of tau polymerization. (2005) (76)
- Structure, Stability, and Aggregation of Paired Helical Filaments from Tau Protein and FTDP-17 Mutants Probed by Tryptophan Scanning Mutagenesis* (2002) (74)
- Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease. (1998) (72)
- Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology (2013) (70)
- Microtubule structure at low resolution by x-ray diffraction. (1977) (69)
- Tau's role in the developing brain: implications for intellectual disability. (2012) (69)
- Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity* (2014) (65)
- Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability (2017) (64)
- Hyperphosphorylation and Aggregation of Tau in Experimental Autoimmune Encephalomyelitis* (2004) (64)
- On the structure of microtubules, tau, and paired helical filaments (1995) (63)
- On the structure of microtubules, tau, and paired helical filaments (1995) (63)
- Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia (2015) (62)
- Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation (2015) (62)
- Structural Variations in the Catalytic and Ubiquitin-associated Domains of Microtubule-associated Protein/Microtubule Affinity Regulating Kinase (MARK) 1 and MARK2* (2006) (60)
- Analysis of in vivo turnover of tau in a mouse model of tauopathy (2015) (60)
- Junctions between microtubule walls. (1979) (57)
- Junctions between microtubule walls. (1979) (57)
- Signaling from MARK to Tau: Regulation, Cytoskeletal Crosstalk, and Pathological Phosphorylation (2006) (55)
- Microtubular structure and tubulin polymerization. (1989) (54)
- Antagonistic Effects of Doublecortin and MARK2/Par-1 in the Developing Cerebral Cortex (2008) (54)
- Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. (2008) (54)
- Microtubular structure and tubulin polymerization. (1989) (54)
- Tau neurotoxicity and rescue in animal models of human Tauopathies (2016) (54)
- Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease (2012) (53)
- ‘Prion-Like’ Propagation of Mouse and Human Tau Aggregates in an Inducible Mouse Model of Tauopathy (2010) (50)
- Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies (2015) (46)
- Tubulin protofilaments and kinesin-dependent motility (1992) (43)
- Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors (2013) (43)
- Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model (2011) (43)
- Effect of MAP2, MAP2c, and tau on kinesin-dependent microtubule motility (1991) (42)
- Engineered antibodies: new possibilities for brain PET? (2019) (42)
- The structure of microtubule motor proteins. (2005) (41)
- A model of microtubule oscillations (2004) (38)
- Tubulin oligomers and microtubule assembly studied by time-resolved X-ray scattering: separation of prenucleation and nucleation events. (1987) (37)
- Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model (2016) (36)
- Making the Brain Glow: In Vivo Bioluminescence Imaging to Study Neurodegeneration (2013) (36)
- Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy. (2010) (34)
- Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition (2017) (33)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Inhibition of tau aggregation in cell models of tauopathy. (2007) (33)
- Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD (2016) (33)
- Histological Markers in Nasal Mucosa of Patients with Alzheimer’s Disease (1998) (32)
- Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280 (2016) (31)
- MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations (2016) (29)
- Microtubule oscillations. (1992) (29)
- Microtubule oscillations. (1992) (29)
- Structure of tubulin rings studied by X-ray scattering using synchrotron radiation. (1983) (28)
- Abeta oligomers cause local missorting of endogenous tau into dendrites, tau phosphorylation, destruction of microtubules and spines (2010) (26)
- Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. (2015) (26)
- FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments (2020) (26)
- Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. (2018) (25)
- N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands. (2011) (24)
- The microtubule lattice--dynamic instability of concepts. (1995) (24)
- Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model (2019) (24)
- The microtubule lattice--dynamic instability of concepts. (1995) (24)
- Microtubule structure studied by quick freezing: Cryo‐electron microscopy and freeze fracture (1986) (23)
- Three-dimensional reconstruction of tubulin sheets and re-investigation of microtubule surface lattice. (1983) (23)
- Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity. (2005) (22)
- Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport (2018) (22)
- Assembly and three-dimensional image reconstruction of tubulin hoops. (1984) (22)
- Assembly and three-dimensional image reconstruction of tubulin hoops. (1984) (22)
- Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems (2018) (20)
- Disruption of microtubules in living cells and cell models by high affinity antibodies to beta‐tubulin. (1985) (19)
- Development of Tau Aggregation Inhibitors for Alzheimer′s Disease. (2009) (19)
- Isoforms of tau protein from mammalian brain and avian erythrocytes: structure, self-assembly, and elasticity. (1990) (18)
- Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy (2017) (18)
- Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation (2018) (17)
- Self-assembly of microtubule protein studied by time-resolved X-ray scattering using temperature jump and stopped flow (1983) (16)
- Anti-aggregant tau mutant promotes neurogenesis (2017) (16)
- Nontubulin Molecules in the Spindle (1977) (14)
- A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications (2020) (14)
- X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity. (2008) (14)
- Paracrystalline structure of the stalk domain of the microtubule motor protein kinesin. (1994) (14)
- Synchrotron radiation as a tool for studying microtubule self-assembly (1983) (13)
- Conformations of microtubule-associated protein Tau mapped by fluorescence resonance energy transfer. (2012) (13)
- Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. (2009) (13)
- Sabeluzole, a memory-enhancing molecule, increases fast axonal transport in neuronal cell cultures (1992) (13)
- Emerging modes of PINK1 signaling: another task for MARK2 (2014) (12)
- Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages. (2017) (12)
- Image reconstruction of tubulin hoops. (1981) (11)
- Networking with proline-directed protein kinases implicated in tau phosphorylation (1995) (11)
- Tau protein and Alzheimer's disease (1994) (11)
- Image reconstruction of tubulin hoops. (1981) (11)
- RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease (2021) (10)
- Quantification of Amyloid Precursor Protein and Tau for the Study of Axonal Traffic Pathways (2007) (9)
- Glycogen Synthase Kinase (GSK) 3 Directly Phosphorylates Serine 212 in the Regulatory Loop and Inhibits Microtubule (2008) (9)
- Novel antibody against low‐n oligomers of tau protein promotes clearance of tau in cells via lysosomes (2020) (8)
- Correlation between structural polarity and polar assembly of brain tubulin. (1979) (8)
- Correlation between structural polarity and polar assembly of brain tubulin. (1979) (8)
- Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment (2018) (7)
- Microtubule assembly and oscillations induced by flash photolysis of caged-GTP (2004) (7)
- Overexpression of tau protein inhibits the outward flow of vesicles and organelles along microtubules (2000) (6)
- Tracking Tau in Neurons: How to Transfect and Track Exogenous Tau into Primary Neurons. (2017) (6)
- Aluminum fluoride, microtubule stability, and kinesin rigor (1991) (5)
- Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability? (2019) (5)
- Influence of tau on neuronal traffic mechanisms (2006) (5)
- Influence of tau on neuronal traffic mechanisms (2006) (5)
- Reconstructions of tubulin protofilaments: different appearances of the same structure. (1984) (5)
- Reconstructions of tubulin protofilaments: different appearances of the same structure. (1984) (5)
- Applications of synchrotron radiation to the study of biopolymers in solution: Time-resolved X-ray scattering of microtubule self-assembly and oscillations (1989) (5)
- Cryo-electron microscopy of unstained frozen-hydrated microtubules. (1986) (5)
- Cryo-electron microscopy of unstained frozen-hydrated microtubules. (1986) (5)
- Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice (2021) (5)
- Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice (2015) (4)
- ROLE OF NUCLEATION AND MICROTUBULE NUMBER CONCENTRATION (1990) (4)
- Quick‐Frozen Microtubules Studied by Cryoelectron Microscopy and Image Processing (1986) (3)
- Tau and Axonal Transport (2007) (2)
- Microtubule assembly in vitro studied by time-resolved X-ray scattering and electron image analysis of kinetic overshoot aggregates (1982) (2)
- Tools for diagnosis and treatment of Alzheimer's disease. (1992) (2)
- Subunit Structure and Conformations of Tubulin Protofilaments (1980) (2)
- Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator. (1993) (2)
- Tau and Axonal Transport (2007) (2)
- Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study (2022) (2)
- Composite microtubular structures from brain tubulin (1978) (1)
- Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice (2014) (1)
- Tau protein and Alzheimer's disease: Phosphorylation and role in intracellular trafficking (2000) (1)
- Atypical, non-standard functions of the microtubule associated Tau protein (2017) (1)
- Making the Brain Glow: In Vivo Bioluminescence Imaging to Study Neurodegeneration (2012) (1)
- P3-255 Mark/PAR1 kinase is a regulator of microtubule-dependent transport in axons by phosphorylating tau protein (2004) (1)
- Crystal structure of a kinase MARK2/Par-1 mutant (2008) (1)
- S2-03-06: The role of tau in axonal transport and neurodegeneration (2008) (1)
- Tau and Intracellular Transport in Neurons (2009) (1)
- Pathway of tau aggregation into Alzheimer paired helical filaments (2000) (1)
- In vivo analysis of methylene blue and kinase inhibitors in a Tau transgenic zebrafish model (2009) (1)
- Structural variations in the catalytic and ubiquitin associated domains of MARK 1 and MARK 2 (2006) (1)
- Spreading of Tau Protein Does Not Depend on Aggregation Propensity (2021) (1)
- The Search for structure of tau and paired helical filaments (2006) (1)
- Microtubular structure and tubulin polymerization. (1989) (1)
- What is the evidence that tau pathology spreads through prion-like propagation? (2017) (1)
- O4-01-02: Neurofibrillary tangles and neuronal loss in an inducible transgenic mouse model expressing a mutant repeat domain of tau (2008) (1)
- Microtubular structure and tubulin polymerization. (1989) (1)
- X-ray diffraction from intermediate(10nm) filaments (1979) (1)
- Inhibition of Tau aggregation in a novel C . elegans model of Tauopathy mitigates proteotoxicity (2012) (1)
- Review Article Tau: From research to clinical development (2016) (0)
- Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model (2019) (0)
- Catalytic and UBA domain of kinase MARK2/(Par-1) K82R, T208E double mutant (2009) (0)
- Reversal of tau-dependent cognitive decay by blocking adenosine A1 receptors in mouse models of tauopathy (2022) (0)
- Tau phosphorylation regulates cell process formation (2000) (0)
- P3-231 Generation of conditional TG mice expressing human tau mutants allows studies of formation and reversal of neurofibrillary pathology (2004) (0)
- Microtubules, Tau Protein,and Paired Helical Filaments in Alzheimer’s Disease (1995) (0)
- P1-022 Diolistic studies of tau pathology in transgenic mice expressing human tau K18 with delK280 mutation (2006) (0)
- KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS (1998) (0)
- Mechanisms of tau toxicity in cell and mouse models (2011) (0)
- S.02.03 Tau toxicity in cell and animal models (2010) (0)
- A novel approach for monitoring tau aggregation in cell models of tauopathy by fluorescence-activated cell sorting (FACS) (2011) (0)
- P3-267 Mimicking phosphorylation within the microtubule-binding repeat domain of tau abolishes microtubule binding and PHF formation (2004) (0)
- A cascade linking A-beta through Tau missorting to destruction of dendritic microtubules by spastin (2014) (0)
- Tau Protein and Alzheimer Paired Helical Filament Assembly: Interacting Domains and Control Residues (1996) (0)
- P3-303 Inhibition of tau aggregation and disaggregation of PHFs by low MW compounds in vitro and in cells (2006) (0)
- Trehalose enhances the degradation of Tau through the autophagy pathway (2011) (0)
- P2-138: Prevention of tau aggregation in vitro and in cells by low molecular weight compounds derived from phenylthiazolyl-hydrazide or rhodanine core structures (2008) (0)
- Rapid aggregation of tau protein into Alzheimer-like paired helical filaments reveals a nucleation-elongation mechanism (2000) (0)
- O1-06-05: Swimming against the tide: Mechanisms of Tau distribution in neurons (2008) (0)
- Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau (2015) (0)
- Microtubule Oscillations ROLE OF NUCLEATION AND MICROTUBULE (2001) (0)
- P2-047 Inducible cell model of tauopathy expressing full-length tau (2006) (0)
- On theSurfaceLatticeofMicrotubules :HelixStarts, Protofilament Number, Seam, andHandedness (2006) (0)
- On theSurfaceLatticeofMicrotubules :HelixStarts, Protofilament Number, Seam, andHandedness (2006) (0)
- U nc or re ct ed P ro of Tau and Intracellular Transport in Neurons (0)
- O2-05-05 Inducible expression of tau in cell models of Alzheimer neurofibrillary pathology causes tau aggregation in a reversible fashion (2004) (0)
- Antibody Mediated Inhibition of TAU Aggregation in In vitro And in Neuronal cells (2019) (0)
- Oscillations in Microtubule Assembly Studied by Time-Resolved X-Ray Scattering (1989) (0)
- PRESYNAPTIC AND POSTSYNAPTIC SIGNALING IN TAU-INDUCED PATHOLOGY (2016) (0)
- Indicators of Tau pathology in organotypic brain slices of inducible transgenic mice (2010) (0)
- Microtubule Structure and Assembly Studied by Time-Resolved X-Ray Scattering and Cryo-Electron Microscopy (1987) (0)
- Tau-induced defects in hippocampal neuroplasticity, learning and memory are reversible in a regulatable transgenic mouse model (2010) (0)
- Short communication Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity (2004) (0)
- Anti-Tau therapy - is it the answer? (2016) (0)
- Dynamics ofthemicrotubule oscillator: role of nucleotides andtubulin -MAP interactions (1988) (0)
- Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD (2016) (0)
- 756 Structure of tau and assembly into paired helical filaments (1996) (0)
- 756 Structure of tau and assembly into paired helical filaments (1996) (0)
- P2-126: Stepwise proteolysis liberates tau fragments that nucleate the aggregation of tau and tau-dependent toxicity in a neuronal cell model (2008) (0)
- FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments (2020) (0)
- The Conformations of Tau Protein and its Aggregation into Alzheimer Paired Helical Filaments (1998) (0)
- Motor domain of Neurospora crassa kinesin-3 (NcKin3) (2008) (0)
- 46 Reversibility of cognitive decline and synapse loss in regulatable mice with tau pathology (2012) (0)
- Motor domain of Neurospora crassa kinesin-3 (NcKin3) (2008) (0)
- The release and trans-synaptic transmission of Tau via exosomes (2017) (0)
- Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment (2018) (0)
- Structural studies of the motor protein kinesin by image reconstruction and X-ray crystallography (1996) (0)
- S.02.03 Tau toxicity in cell and animal models (2010) (0)
- A study of microtubule self-assembly by means of time-resolved X-ray scattering (1981) (0)
- P2-044 Inducible cell models of tauopathy show that tau aggregation is toxic to cells, but tau pathology can be reversed (2006) (0)
- 172 Macromolecular assemblages ® 8 nm discontinuity ® (2004) (0)
- Anti-aggregant tau mutant promotes neurogenesis (2017) (0)
- Paracrystals of Tau Protein — A Molecular Accordion (1989) (0)
- Paracrystals of Tau Protein — A Molecular Accordion (1989) (0)
- Phosphorylierungsepitope from the tau protein in the diagnosis and treatment of Alzheimer's disease (1992) (0)
- Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia (2015) (0)
- Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation (2015) (0)
- Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model (2016) (0)
- Hyperphosphorylation of tau in PHF (1995) (0)
- A worm model of tauopathy (2011) (0)
- Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type (2006) (0)
- P2-135: Mechanisms of neuronal traffic inhibition by tau protein (2008) (0)
- Analysis of in vivo turnover of tau in a mouse model of tauopathy (2015) (0)
- Synchrotron X-ray studies of biopolymers: self-assembly and oscillations of microtubules. (1989) (0)
- Tau cleavage by calpain: The intermediate at Mr 17kD / MW 11kD is metastable but not toxic (2011) (0)
- Recovered learning and memory functions through tau suppression in an inducible mouse model (oral presentation) (2008) (0)
- S3-02-01 Principles of assembly of tau protein into Alzheimer paired helical filaments (2004) (0)
- Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant (2006) (0)
- Structure of the catalytic and UBA domains of the kinase MARK 1 (2003) (0)
- System in Alzheimer Disease Lysosomal - Proteasome System and the Autophagic - The Ubiquitin (2012) (0)
- Tubulin Structure and Nucleotide Binding (1989) (0)
- Synchrotron X-ray studies of biopolymers: self-assembly and oscillations of microtubules. (1989) (0)
- Conformational analysis of tau and tau aggregates by fluorescence spectroscopy (2005) (0)
- The dual role of tau in cell polarisation and organelle trafficking (2001) (0)
- Neuronal kinase stimulation leads to aberrant tau phosphorylation and neurotoxicity (1995) (0)
- Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant (2006) (0)
- DomainsofTauProtein, Differential Phosphorylation, andDynamicInstability ofMicrotubules (1995) (0)
- Motor protein interactions with tubulin protofilaments (1998) (0)
- Microtubule assembly studied by time-resolved X-ray scattering (1980) (0)
- MATERIALS AND METHODS Preparation of Pig Brain and Chicken Erythrocyte Tubulin (0)
- O2-04-04 Formation of tau pathology in transgenic mice conditionally expressing human tau with delK280 mutation impairs synaptic plasticity in hippocampal neurons (2006) (0)
- MATERIALS AND METHODS Preparation of Pig Brain and Chicken Erythrocyte Tubulin (0)
- Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Inactive double mutant with selenomethionine (2006) (0)
- Monoclonal antibodies against the protein tau mikrotubulusassoziierte. (1992) (0)
- Role of Tau, Tau kinases, and microtubule dynamics in neurite growth and degeneration (2004) (0)
- Role of Tau, Tau kinases, and microtubule dynamics in neurite growth and degeneration (2004) (0)
- Catalytic and ubiqutin-associated domains of MARK1/PAR-1 (2006) (0)
- Human kinase MARK/Par-1: Structure of catalytic and ubiquitin-associated domains (2007) (0)
- P1-085 Neurofibrilary tangle formation and neuronal loss in an inducible transgenic mouse model expressing 4R repeat tau domain with DelK280 mutation (2006) (0)
- Means for the diagnosis and treatment of Alzheimer's disease (1992) (0)
- O4-05-06 Linkage between axonal transport and Aβ generation (2006) (0)
- PL-2-3 TAU and tauopathy: physiological role and pathological dysfunction (2004) (0)
- Cognitive decline and defects in neuroplasticity are reversible in an inducible mouse model expressing pro-aggregant full-length human tau (2011) (0)
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