Evgeny Nudler
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U.S. biochemist
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Evgeny Nudlerbiology Degrees
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Biology
Evgeny Nudler's Degrees
- PhD Biochemistry Moscow State University
Why Is Evgeny Nudler Influential?
(Suggest an Edit or Addition)According to Wikipedia, Evgeny Nudler is an American biochemist, currently the Julie Wilson Anderson Professor at New York University School of Medicine. He is an investigator with the Howard Hughes Medical Institute and is best known for his pioneering work on the molecular mechanisms of transcription elongation and termination, mechanisms of cellular adaptation to genotoxic and proteotoxic stress, as well as his role in the discovery of riboswitches and RNA polymerase backtracking.
Evgeny Nudler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Decade of Riboswitches (2013) (809)
- Sensing Small Molecules by Nascent RNA A Mechanism to Control Transcription in Bacteria (2002) (608)
- The riboswitch control of bacterial metabolism. (2004) (561)
- H2S: A Universal Defense Against Antibiotics in Bacteria (2011) (540)
- Cooperation Between Translating Ribosomes and RNA Polymerase in Transcription Elongation (2010) (482)
- The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase (1997) (424)
- RNA-mediated response to heat shock in mammalian cells (2006) (366)
- The mechanism of intrinsic transcription termination. (1999) (353)
- Endogenous Nitric Oxide Protects Bacteria Against a Wide Spectrum of Antibiotics (2009) (352)
- A Ratchet Mechanism of Transcription Elongation and Its Control (2005) (329)
- Linking RNA Polymerase Backtracking to Genome Instability in E. coli (2011) (281)
- Termination Factor Rho and Its Cofactors NusA and NusG Silence Foreign DNA in E. coli (2008) (261)
- NO-mediated cytoprotection: instant adaptation to oxidative stress in bacteria. (2005) (261)
- The riboswitch-mediated control of sulfur metabolism in bacteria (2003) (240)
- Transcription-replication encounters, consequences and genomic instability (2013) (230)
- RNA Polymerase Backtracking in Gene Regulation and Genome Instability (2012) (219)
- Transcription termination and anti‐termination in E. coli (2002) (218)
- Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli. (1992) (214)
- Cooperation Between RNA Polymerase Molecules in Transcription Elongation (2003) (214)
- New insights into the mechanism of heat shock response activation (2008) (196)
- Transcription through the roadblocks: the role of RNA polymerase cooperation (2003) (195)
- Motion and enzymatic degradation of DNA in the atomic force microscope. (1994) (194)
- UvrD facilitates DNA repair by pulling RNA polymerase backwards (2014) (192)
- Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages (2008) (188)
- Transcription Processivity: Protein-DNA Interactions Holding Together the Elongation Complex (1996) (187)
- Riboswitch control of Rho-dependent transcription termination (2012) (175)
- Riboswitch-dependent gene regulation and its evolution in the plant kingdom. (2007) (165)
- An allosteric mechanism of Rho-dependent transcription termination (2010) (159)
- Bacterial Nitric Oxide Extends the Lifespan of C. elegans (2013) (155)
- RNA polymerase active center: the molecular engine of transcription. (2009) (151)
- RNA polymerase holoenzyme: structure, function and biological implications. (2003) (150)
- sRNA-Mediated Control of Transcription Termination in E. coli (2016) (148)
- Bacterial Nitric-oxide Synthases Operate without a Dedicated Redox Partner* (2008) (147)
- Control of Intrinsic Transcription Termination by N and NusA The Basic Mechanisms (2001) (146)
- RNA polymerase: the vehicle of transcription. (2008) (141)
- An autocatalytic mechanism of protein nitrosylation. (2000) (139)
- Transcription inactivation through local refolding of the RNA polymerase structure (2009) (135)
- Catalysis of S-nitrosothiols formation by serum albumin: The mechanism and implication in vascular control (2002) (134)
- Coupling between transcription termination and RNA polymerase inchworming (1995) (133)
- Discontinuous mechanism of transcription elongation. (1994) (133)
- Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response (2009) (126)
- An allosteric path to transcription termination. (2007) (123)
- Mechanism of H2S-mediated protection against oxidative stress in Escherichia coli (2017) (120)
- Transcription elongation: structural basis and mechanisms. (1999) (116)
- The translation elongation factor eEF1A1 couples transcription to translation during heat shock response (2014) (116)
- Thermodynamic and kinetic modeling of transcriptional pausing. (2006) (114)
- Isolation and Characterization of σ70-Retaining Transcription Elongation Complexes from Escherichia coli (2001) (114)
- RNA polymerase and the ribosome: the close relationship. (2013) (108)
- Extensive functional overlap between sigma factors in Escherichia coli. (2006) (101)
- ppGpp couples transcription to DNA repair in E. coli (2016) (101)
- Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex (2020) (98)
- Therapeutic effect of exogenous hsp70 in mouse models of Alzheimer's disease. (2013) (97)
- Extensive functional overlap between σ factors in Escherichia coli (2006) (97)
- Rates and Mechanisms of Bacterial Mutagenesis from Maximum-Depth Sequencing (2016) (95)
- Assessment of nitric oxide signals by triiodide chemiluminescence (2007) (89)
- Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination. (2019) (88)
- Methicillin-resistant Staphylococcus aureus Bacterial Nitric-oxide Synthase Affects Antibiotic Sensitivity and Skin Abscess Development* (2013) (86)
- Histidine-tagged RNA polymerase of Escherichia coli and transcription in solid phase. (1996) (85)
- Spatial organization of transcription elongation complex in Escherichia coli. (1998) (80)
- The ratcheted and ratchetable structural states of RNA polymerase underlie multiple transcriptional functions. (2015) (78)
- Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress (2017) (75)
- Exogenous Hsp70 delays senescence and improves cognitive function in aging mice (2015) (71)
- Mechanistic model of the elongation complex of Escherichia coli RNA polymerase. (1998) (67)
- Structure of RNA polymerase bound to ribosomal 30S subunit (2017) (64)
- Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4 (2018) (63)
- Paf1C regulates RNA polymerase II progression by modulating elongation rate (2019) (61)
- Transcription regulatory elements are punctuation marks for DNA replication. (2006) (59)
- Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance (2021) (58)
- Basic mechanism of transcription by RNA polymerase II. (2013) (58)
- Mechanistic insights into transcription coupled DNA repair. (2017) (51)
- Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer (2018) (50)
- Bacteriophage T4 Alc protein: A transcription termination factor sensing local modification of DNA (1993) (50)
- A unified model of transcription elongation: what have we learned from single-molecule experiments? (2011) (49)
- Flipping Riboswitches (2006) (46)
- The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach. (2019) (45)
- Gene Control by Large Noncoding RNAs (2006) (41)
- Pre-termination Transcription Complex: Structure and Function. (2020) (40)
- Rethinking transcription coupled DNA repair. (2015) (39)
- Bacterial gasotransmitters: an innate defense against antibiotics. (2014) (39)
- Natural RNA Polymerase Aptamers Regulate Transcription in E. coli. (2017) (39)
- H2S, a Bacterial Defense Mechanism against the Host Immune Response (2018) (38)
- Macromolecular micromovements: how RNA polymerase translocates. (2009) (37)
- Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans (2017) (36)
- Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain. (2014) (36)
- The RNA polymerase bridge helix YFI motif in catalysis, fidelity and translocation. (2013) (36)
- Trigger loop folding determines transcription rate of Escherichia coli’s RNA polymerase (2014) (36)
- Control of Plasma Nitric Oxide Bioactivity by Perfluorocarbons: Physiological Mechanisms and Clinical Implications (2004) (34)
- Methods of walking with the RNA polymerase. (2003) (32)
- Dietary thiols accelerate aging of C. elegans (2021) (31)
- Tagetitoxin Inhibits RNA Polymerase through Trapping of the Trigger Loop* (2011) (30)
- New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson's disease (2018) (30)
- Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH. (2016) (29)
- The structure of a virus-encoded nucleosome (2021) (28)
- Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice (2012) (26)
- Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction (2021) (26)
- Template switching by RNA polymerase II in vivo. Evidence and implications from a retroviral system. (2002) (26)
- Isolation and characterization of the heat shock RNA 1. (2009) (23)
- RNA polymerase stalls in a post-translocated register and can hyper-translocate (2012) (23)
- Riboswitches in regulation of Rho-dependent transcription termination. (2014) (23)
- A Magic Spot in Genome Maintenance. (2017) (22)
- Protein S-Nitrosylation: Enzymatically Controlled, but Intrinsically Unstable, Post-translational Modification. (2018) (17)
- Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state (2021) (16)
- Analysis of the intrinsic transcription termination mechanism and its control. (2003) (14)
- Upregulation of cystathione β‐synthase and p70S6K/S6 in neonatal hypoxic ischemic brain injury (2017) (14)
- S-Nitrosylation Signaling in Escherichia coli (2012) (14)
- Rho-dependent transcription termination: a revisionist view (2021) (14)
- Unfolding the Bridge between Transcription and Translation (2012) (13)
- Transcription factor YcjW controls the emergency H2S production in E. coli (2019) (13)
- iRAPs curb antisense transcription in E. coli (2019) (12)
- Pervasive Transcription-coupled DNA repair in E. coli (2022) (12)
- CydDC functions as a cytoplasmic cystine reductase to sensitize Escherichia coli to oxidative stress and aminoglycosides (2020) (12)
- Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides (2021) (12)
- Adaptive mutations in RNA-based regulatory mechanisms Computational and experimental investigations (2006) (11)
- S-nitrosylation of peroxiredoxin 1 contributes to viability of lung epithelial cells during Bacillus anthracis infection. (2017) (11)
- Antibiotic killing through oxidized nucleotides (2018) (10)
- Variation in FPOP Measurements Is Primarily Caused by Poor Peptide Signal Intensity (2018) (10)
- Clamping the clamp of RNA polymerase (2011) (10)
- Crucial role and mechanism of transcription-coupled DNA repair in bacteria (2022) (10)
- Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging (2018) (9)
- Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials (2021) (8)
- Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity (2020) (8)
- Jamming the ratchet of transcription (2008) (7)
- STR2: A structure to string approach for locating G-box riboswitch shapes in pre-selected genes (2004) (7)
- Transcriptional approaches to riboswitch studies. (2009) (6)
- Shelterin is a dimeric complex with extensive structural heterogeneity (2022) (6)
- Ratcheting of RNA polymerase toward structural principles of RNA polymerase operations (2015) (6)
- Reactive oxygen species as the long arm of bactericidal antibiotics (2019) (6)
- Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long‐evans rats (2021) (4)
- Methicillin-resistantStaphylococcus aureusBacterial Nitric-oxide Synthase Affects Antibiotic Sensitivity (2013) (4)
- Characterization of protein-nucleic acid interactions that are required for transcription processivity. (2003) (4)
- Looking for a promoter in 3D (2013) (4)
- Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides (2021) (4)
- Modular RNA heats up. (2008) (4)
- Reactive rifampicin derivative able to damage transcription complex. (2013) (3)
- Towards the unified principles of transcription termination (2019) (3)
- Reading of the non‐template DNA by transcription elongation factors (2018) (3)
- Erratum to: Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice (2012) (3)
- Inheritance of repressed chromatin domains during S phase requires the histone chaperone NPM1 (2022) (3)
- An allosteric mechanism of Rho-dependent transcription termination (2010) (3)
- Response to Klyuyev and Vassylyev: On the mechanism of tagetitoxin inhibition of transcription (2012) (3)
- Inheritance of Repressed Chromatin Domains during S-phase Requires the Histone Chaperone NPM1 (2021) (3)
- PIM1 phosphorylation of the androgen receptor and 14-3-3 ζ regulates gene transcription in prostate cancer (2021) (2)
- Strategies and Methods of Transcription-Coupled Repair Studies In Vitro and In Vivo. (2017) (2)
- Author response: Structure of RNA polymerase bound to ribosomal 30S subunit (2017) (2)
- Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9 (2021) (2)
- Transcription factor YcjW controls the emergency H2S production in E. coli (2019) (1)
- Lost in translation: codon optimization inactivates SARS-CoV-2 RdRp (2021) (1)
- Site-specific photolabile roadblocks for the study of transcription elongation in biologically complex systems (2022) (1)
- Control of transcription elongation and DNA repair by alarmone ppGpp. (2023) (1)
- Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer (2018) (1)
- H2S as a Bacterial Defense Against Antibiotics (2013) (1)
- PP82 – Systemic infection and combined burn and infection: Contribution of host-derived and bacteria-derived hydrogen sulfide production to bacterial clearance (2015) (1)
- The very hungry bactericidal antibiotics (2022) (1)
- Supplemental Data An Allosteric Path to Transcription Termination (2007) (1)
- Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE (2023) (1)
- Nitric oxide produced by bacteria extends Caenorhabditis elegans lifespan (2012) (1)
- CMET-46. EXPRESSION OF HYDROGEN SULFIDE (H2S) PRODUCING ENZYMES IN METASTATIC BRAIN TUMORS (2017) (1)
- Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice (2012) (1)
- Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans (2017) (1)
- Uncovering Caprin1's biological role to understand it's function in autism (2019) (0)
- Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1 (2023) (0)
- Dynamics of Mismatch and Alternative Excision-Dependent Repair in Replicating Bacillus subtilis DNA Examined Under Conditions of Neutral Selection (2022) (0)
- O23. bNOS: A key player in bacterial adaptation to stress (2008) (0)
- Structural Basis of Dot 1 L S timulation by Histone H 2 B Lysine 120 Ubiquitination Graphical (2019) (0)
- The Molecular Architectur e of Native BBSome Obtained by an Integrated Structural Approach Graphical (2019) (0)
- MPTH-24. CYSTATHIONE β-SYNTHASE EXPRESSION IN ASTROCYTOMAS INCREASES WITH HISTOPATHOLOGICAL GRADE (2016) (0)
- Erratum to: Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice (2012) (0)
- Chapter 10:Mechanics of Transcription Termination (2009) (0)
- RNA polymerase and ppGpp deliver a one-two punch to antibiotics. (2023) (0)
- Kinetic Modelling of Transcription Elongation (2006) (0)
- En'Cas'ing The Stress: Engineering a Human Cell Line Knockout of Heat Shock Response Coordinator Genes Using CRISPR Cas9 System (2016) (0)
- Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1 (2023) (0)
- Supplementary Material for "A unified model of transcription elongation. What have we learned from single-molecule experiments?" (2010) (0)
- P075. A mechanism of NO mediated protein nitration and mechanism of denitration by thiols (2006) (0)
- YcjW: a transcription factor that controls the emergency generator of H2S in E. coli (2018) (0)
- CryoEM Structure of E. coli Rho-dependent Transcription Pre-termination Complex (2020) (0)
- Thermodynamic Model of Transcription Elongation (2006) (0)
- Bacterial Strategies for Silencing Foreign DNA (2011) (0)
- A New Look at Transcription‐Coupled DNA Repair (2015) (0)
- Structure of 30S ribosomal subunit and RNA polymerase complex in non-rotated state (2017) (0)
- CBMT-21. ALTERATIONS OF CYSTEINE METABOLISM IN GENETIC VARIANTS OF HIGH GRADE GLIOMAS (2018) (0)
- Bacterial nitric-oxide synthases operate without a dedicated redox partner. VOLUME 283 (2008) PAGES 13140-13147 (2008) (0)
- Bacterial Toxic Oxidants in Healthy Aging and Disease (2020) (0)
- CryoEM Structure of E. coli Rho-dependent Transcription Pre-termination Complex bound with NusG (2020) (0)
- Upregulation of cystathione b-synthase and p 70 S 6 K / S 6 in neonatal hypoxic ischemic brain injury (2016) (0)
- Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9 (2021) (0)
- Structure of 30S (S1 depleted) ribosomal subunit and RNA polymerase complex (2017) (0)
- Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4 (2018) (0)
- P152. Cardiomyocyte fate in ischemia/reperfusion is controlled by nitric oxide (2006) (0)
- Author response: The translation elongation factor eEF1A1 couples transcription to translation during heat shock response (2014) (0)
- Dot1L bound to the H2BK120 Ubiquitinated nucleosome (2019) (0)
- S7-6 Role of H2S and NO in Bacillus anthracis spore formation and virulence (2014) (0)
- An automated workflow for the discovery and docking simulation of the protein-protein complexes using in vivo chemical cross-linking (2018) (0)
- O04. Instant adaptation to oxidative stress in bacteria is mediated by NO (2006) (0)
- Analysis of the impact of molecular motions on the efficiency of XL-MS and the distance restraints in hybrid structural biology (2018) (0)
- Crucial role and mechanism of transcription-coupled DNA repair in bacteria (2022) (0)
- Publisher Correction: Dietary thiols accelerate aging of C. elegans (2021) (0)
- Explorer The translation elongation factor eEF 1 A 1 couples transcription to translation during heat shock response (2016) (0)
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