Francis A. Fitzpatrick

Francis A. Fitzpatrick's AcademicInfluence.com Rankings

Philosophy

#9382

World Rank

#12935

Historical Rank

Logic

#6362

World Rank

#7874

Historical Rank

philosophy Degrees

Francis A. Fitzpatrick

Biology

#12901

World Rank

#16407

Historical Rank

Biochemistry

#2229

World Rank

#2375

Historical Rank

biology Degrees

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Philosophy
Biology

Francis A. Fitzpatrick's Degrees

PhD Biochemistry University of California, Berkeley
Doctorate Medicine Stanford University

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Francis A. Fitzpatrick's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. (1990) (646)
Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. (1983) (335)
Cyclooxygenase-2 and carcinogenesis. (2000) (285)
Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids. (1988) (258)
Cyclooxygenase enzymes: regulation and function. (2004) (242)
Regulated formation of eicosanoids. (2001) (218)
Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase* (2003) (164)
Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma. (1981) (154)
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. (1986) (153)
Inflammation, carcinogenesis and cancer. (2001) (149)
Erythrocyte-neutrophil interactions: formation of leukotriene B4 by transcellular biosynthesis. (1986) (147)
Inhibition of phospholipase C dependent processes by U-73, 122. (1989) (142)
Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase (*) (1996) (140)
Albumin stabilizes leukotriene A4. (1982) (138)
Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. (1998) (137)
Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. (1996) (136)
Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. (2005) (134)
Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4. (1984) (132)
Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes Their Transcriptional Repressor Function* (2010) (125)
Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. (1991) (125)
A radioimmunoassay for thromboxane B2. (1977) (125)
Cyclopentenone Prostaglandins of the J Series Inhibit the Ubiquitin Isopeptidase Activity of the Proteasome Pathway* (2001) (123)
Synthesis and structure of the platelet aggregation factor thromboxane A2 (1985) (122)
Curcumin impairs tumor suppressor p53 function in colon cancer cells. (2004) (122)
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. (1985) (119)
Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances. (1979) (118)
5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. (1994) (115)
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles. (2006) (108)
The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity. (1994) (108)
In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents. (1976) (107)
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells (1979) (107)
Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death. (2002) (104)
The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents. (2003) (103)
Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid. (1977) (102)
The stability of 13,14-dihydro-15 keto-PGE2. (1980) (99)
Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential. (1979) (94)
Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor (2007) (92)
Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon. (1981) (81)
Virus and interferon effects on cellular prostaglandin biosynthesis. (1980) (80)
Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. (1991) (75)
6,9-deepoxy-6,9,-(phenylimino)-delta 6,8-prostaglandin I1, (U-60,257), a new inhibitor of leukotriene C and D synthesis: in vitro studies. (1982) (72)
Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits. (1998) (72)
High resolution liquid chromatography of derivatized nonultraviolet absorbing hydroxy steroids (1973) (71)
Oximes for high performance liquid and electron capture gas chromatography of prostaglandins and thromboxanes. (1977) (68)
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. (2000) (67)
Reactive Lipid Species from Cyclooxygenase-2 Inactivate Tumor Suppressor LKB1/STK11 (2006) (67)
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. (1992) (66)
Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer (2010) (65)
High performance liquid chromatographic determination of prostaglandins F2alpha, E2, and D2 from in vitro enzyme incubations. (1976) (64)
Transcellular biosynthesis of eicosanoids. (1989) (64)
Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. (1983) (63)
Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization. (1992) (62)
Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity. (2004) (61)
A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics. (1982) (61)
A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. (1978) (59)
9,11-Epoxyiminoprosta-5,13-dienoic acid is a thromboxane A2 antagonist in human platelets (1978) (58)
Biological activity and metabolism of 20‐hydroxyeicosatetraenoic acid in the human platelet (1992) (55)
Metabolism of leukotriene A4 by an enzyme in blood plasma: a possible leukotactic mechanism. (1983) (52)
Nitric oxide modulates the activity of the hemoproteins prostaglandin I2 synthase and thromboxane A2 synthase. (1997) (51)
Albumin-eicosanoid interactions. A model system to determine their attributes and inhibition. (1984) (49)
Platelet rich plasma transforms exogenous prostaglandin endoperoxide H2 into thromboxane A2. (1977) (47)
Human neutrophil activation with interleukin-1. A role for intracellular calcium and arachidonic acid lipoxygenation. (1987) (46)
Glass capillary gas chromatography with electron-capture detection. Separation of prostaglandins. (1979) (46)
Inhibition of mitogen-activated protein kinase kinase blocks activation and redistribution of 5-lipoxygenase in HL-60 cells. (1996) (45)
Effect of taxol and taxotere on gene expression in macrophages: induction of the prostaglandin H synthase-2 isoenzyme. (1999) (45)
High speed liquid chromatography of derivatized urinary 17-keto steroids. (1972) (42)
Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase. (1992) (41)
Reciprocal regulation of human platelet cAMP levels by thromboxane A2 and prostacyclin. (1978) (40)
5-Lipoxygenase compartmentalization in granulocytic cells is modulated by an internal bipartite nuclear localizing sequence and nuclear factor kappa B complex formation. (1998) (40)
High-performance liquid chromatographic assay for prostacyclin. (1979) (38)
Mechanism-based inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. (1990) (38)
Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase. (1992) (38)
Irreversible inactivation of 5-lipoxygenase by leukotriene A4. Characterization of product inactivation with purified enzyme and intact leukocytes. (1994) (37)
Leukotriene A4-hydrolase activity in guinea pig and human liver. (1985) (36)
Hapten mimic elicits antibodies recognizing prostaglandin E2. (1978) (36)
"Suicide" inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. (1990) (36)
Conditional Expression of 15-Lipoxygenase-1 Inhibits the Selenoenzyme Thioredoxin Reductase (2004) (35)
Oxidation of 2-Cys-peroxiredoxins by Arachidonic Acid Peroxide Metabolites of Lipoxygenases and Cyclooxygenase-2* (2007) (35)
Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. (1992) (34)
Cell damage unmasks 15-lipoxygenase activity in human neutrophils. (1985) (34)
Genomics and the discovery of new drug targets. (1999) (33)
Cyclooxygenase-2 induction by paclitaxel, docetaxel, and taxane analogues in human monocytes and murine macrophages: structure-activity relationships and their implications. (2002) (33)
"Suicide" inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells. (1995) (30)
Separation of prostaglandins and thromboxanes by gas chromatography with glass capillary columns (1978) (30)
Thromboxane A2 synthase. Modification during "suicide" inactivation. (1991) (28)
Thromboxane B2 (TxB2) release following acetyl glyceryl ether phosphorylcholine (AGEPC) infusion in the rabbit. (1983) (27)
A rapid, solid phase radioimmunoassay for prostaglandin F2alpha and its main circulating metabolite. (1976) (27)
Electron capture gas chromatographic detection of thromboxane B2. (1977) (25)
Development and comparative evaluation of radioimmunoassay and gas chromatographic/mass spectrometric procedures for determination of leukotriene B4. (1988) (25)
A selective thromboxane synthetase inhibitor blocks the cAMP lowering activity of PGH2. (1977) (25)
Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. (1979) (24)
Comparison between circulating interferon and drug levels following administration of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) to different animal species. (1982) (24)
Leukotriene-induced contraction and thromboxane production in guinea-pig lung parenchymal strips. (1984) (24)
9,11-Iminoepoxyprosta-5,13-dienoic acid is a selective thromboxane A2 synthetase inhibitor. (1979) (23)
Prostacyclin biosynthesis in activated, stimulated and normal mouse peritoneal cell populations. (1978) (23)
Inhibitors of arachidonic acid metabolism: effects on rat striatal dopamine release and uptake. (1991) (22)
Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. (1983) (22)
Hemoprotein catalysis of leukotriene formation. (1984) (22)
The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2’deoxycytidine (decitabine) are differentially regulated by cell cycle progression (2011) (22)
[41] A radioimmunoassay for thromboxane B2 (1982) (20)
Receptor antagonism of leukotriene B4 myotropic activity by the 2,6 disubstituted pyridine analog U-75302: characterization on lung parenchyma strips. (1989) (20)
Albumin-lipid interactions: prostaglandin stability as a probe for characterizing binding sites on vertebrate albumins. (1981) (20)
Determination of leukotriene C4 by radioimmunoassay with a specific antiserum generated from a synthetic hapten mimic. (1984) (18)
Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum (1990) (18)
Liquid chromatographic determination of intact leukotriene A4 (1982) (18)
Phase I study of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP), an oral interferon inducer, in cancer patients. (1986) (16)
Modulation of pulmonary leukotriene formation and perfusion pressure by bestatin, an inhibitor of leukotriene A4 hydrolase. (1994) (16)
Indirect actions of thapsigargin on human platelets: activation of eicosanoid biosynthesis and cellular signaling pathways. (1992) (16)
Arachidonate related lipid mediators (1990) (13)
Gas chromatography of the prostaglandins. (1978) (12)
Cardiovascular and renal actions of cytochrome P-450 metabolites of arachidonic acid. (1989) (12)
In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. (1983) (12)
Chapter 10 The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways (1991) (12)
Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of ApcMin/+ mice☆ (2015) (11)
High-performance liquid chromatographic analysis of prostaglandins formed during in vitro incubations with prostaglandin 15-dehydrogenase. (1976) (11)
Arachidonic acid and 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid modulate human polymorphonuclear neutrophil activation by monocyte derived neutrophil activating factor. (1987) (10)
Leukotriene B4 and 20-hydroxyleukotriene B4 contract guinea-pig trachea strips in vitro. (1986) (10)
A comparison of absorption-inhibition and absorption-elution methods in the detection of ABO(H) antigens found in vaginal samples submitted in sexual offense cases. (1978) (9)
High-performance liquid chromatography of the steroid hormones. (1978) (9)
Suicide Inactivation of Leukotriene A4 Hydrolase/Aminopeptidase a (1994) (8)
Plasma levels of the prodrug, arbaprostil, [(15R)-15-methylprostaglandin E2], and its active, antiulcer (15S) epimer in humans after single dose oral administration. (1986) (8)
Chapter 11 – The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways (1996) (7)
Albumin stabilizes 14,15‐leukotriene A4 (1983) (7)
Piriprost: a selective inhibitor of leukotriene synthesis. (1985) (7)
An antiserum against 9,11-azo-15-hydroxy-prosta-5,13-dienoic acid recognises and binds prostaglandin endoperoxides (1978) (7)
Influence of thromboxane synthetase inhibitors on virus replication in human lung fibroblasts in vitro. (1983) (7)
Genesis and "suicide" of eicosanoid biosynthetic enzymes. (1991) (7)
Hydrolysis of an orally active platelet inhibitory prostanoid amide in the plasma of several species. (1980) (6)
High-performance liquid chromatographic determination of 5-halopyrimidinone interferon inducers. (1980) (6)
MGMT methylation in newly-diagnosed glioblastoma multiforme (GBM): From the S0001 phase III study of radiation therapy (RT) and O6-benzylguanine, (O6BG) plus BCNU versus RT and BCNU alone for newly diagnosed GBM. (2006) (6)
PGD3 is the mediator of the antiaggregatory effects of the trienoic endoperoxide PGH3. (1980) (6)
Signal transduction pathways involved in presynaptic receptor-mediated inhibition of dopamine release in rat striatum (1992) (6)
Myotropic activity of leukotriene B4 on lung parenchyma strips is not necessarily attributable to thromboxane A2 release. (1988) (6)
Fiberoptic Resonance Raman Spectroscopy to Measure Carotenoid Oxidative Breakdown in Live Tissues (2010) (6)
An antiserum against 9-deoxy-6,9-epoxy-PGF1alpha recognizes and binds PGI2 (prostacyclin). (1978) (5)
Pharmacology of synthetic thromboxane A2. (1987) (5)
Effects of Leukotriene A4 on Neutrophil Activation a (1994) (5)
Novel effects of epoxyeicosatrienoic acid isomers: inhibition of platelet aggregation and cyclooxygenase activity. (1987) (4)
Hapten mimic elicits antibodies recognizing prostaglandin E 2 ( isosteric hapten / immunochemical mimic / radioimmunoassay ) (3)
14, 15-cis-episulfide-eicosatrienoic acid, an 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation. (1991) (3)
Some observations on vaginal phosphoglucomutase. (1978) (3)
Modification of leukotriene A(4) hydrolase/aminopeptidase by sulfhydryl-blocking reagents: differential effects on dual enzyme activities by methyl-methane thiosulfonate. (1999) (3)
Leukotriene B4 biosynthesis by erythrocyte-neutrophil interactions. (1990) (3)
Mechanism-based inactivation of thromboxane A2 synthase. (1991) (2)
The Stability of Eicosanoids: Analytical Consequences (1980) (2)
Nitrile-terminated hydrocarbons as stationary phases for high-performance liquid chromatography of steroid hormones. (1973) (2)
Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid. (1989) (2)
Effect of Piriprost, a 5-lipoxygenase inhibitor, on leukocyte accumulation during thioglycollate-induced acute inflammation. (1986) (2)
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation. (1990) (1)
Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2. (1995) (1)
Radioimmunologic determination of 15-keto-13,14-dihydro-PGE2: a method for its stable degradation product, 11-deoxy-15-keto-13,14-dihydro-11 beta, 16 xi-cyclo-PGE2. (1982) (1)
Prostaglandin formation by murine malignant melanoma cells: inverse correlation with metastasis. (1981) (1)
A radioimmunoassay for thromboxane B2. (1977) (1)
Determination of leukotriene C4 by radioimmunoassay with a specific antiserum against a synthetic hapten. (1985) (0)
Pharmacodynamic study of gefitinib in skin from patients with recurrent carcinoma of head + neck (2005) (0)
Alternate Functions for Aminopeptidases: Hydrolysis of Leukotriene A4 (1996) (0)
Formation and Mechanism of Action of Epoxyeicosatrienoic Acids (1989) (0)
Leukotrienes as mediators of immediate hypersensitivity. (1985) (0)
Thromboxane A2 synthesis in human erythroleukemia cells. (1991) (0)
Improving the therapeutic value of DNA methylation inhibitors (2005) (0)
Factors affecting prostaglandin endoperoxide transformation: antibodies against PGH2. (1981) (0)
Prostaglandin H Synthase-2 Isoenzyme Expression in Macrophages : Induction of the Effect of Taxol and Taxotere on Gene (1998) (0)
Transcriptional Repressor Function 2 , and 3 and Antagonizes Their Inactivates Class I Histone Deacetylases 1 , ( Carbonylation ) of Conserved Cysteines Redox Signaling , Alkylation Signal Transduction : (2010) (0)
In Vivo Disposition of Prostaglandin E1 Via Pharmacokinetic Characterization of Its Pulmonary Metabolite (1982) (0)
Abstract 2274: Effect of myeloperoxidase inhibitor resorcinol on colon tumorigenesis in APCmin/+ mice (2010) (0)
Abstract 4388: beta-Carotene's oxidative breakdown inhibits p53 conformational folding and function (2010) (0)
Formation and mechanism of action of leukotrienes: enzymatic hydration of leukotriene A4 by human blood cells (1984) (0)
Evaluating 2-chlorodeoxycytidine for its novel mechanism as a DNA methylation inhibitor. (2004) (0)
Metabolism ofleukotriene A4byanenzymeinbloodplasma: A possible leukotactic mechanism (1983) (0)
National Educational Association (1901) (0)
THE SYNTHESIS OF COMPOUNDS FORMED IN THE ARACHIDONIC ACID CASCADE AND AGENTS WHICH MODULATE THEIR PRODUCTION (1979) (0)

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Francis A. Fitzpatrick is affiliated with the following schools:

University of Utah

Francis A. Fitzpatrick's Academic­Influence.com Rankings

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Francis A. Fitzpatrick's Published Works

Published Works

What Schools Are Affiliated With Francis A. Fitzpatrick?

Francis A. Fitzpatrick's AcademicInfluence.com Rankings