F. Merlin Bumpus
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Medical Biology
F. Merlin Bumpus's Degrees
- PhD Biochemistry University of California, Berkeley
- Doctorate Medicine University of California, San Francisco
Why Is F. Merlin Bumpus Influential?
(Suggest an Edit or Addition)F. Merlin Bumpus's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. (1990) (877)
- Angiotensin II-forming pathways in normal and failing human hearts. (1990) (601)
- Cardiac Hypertrophy in Spontaneously Hypertensive Rats (1974) (431)
- Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. (1993) (407)
- Measurement of Renin Activity in Human Plasma (1965) (271)
- Cardiac hypertrophy and antihypertensive therapy. (1977) (268)
- Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor. (1991) (210)
- Effect of Converting Enzyme Inhibitor (SQ14,225) on Myocardial Hypertrophy in Spontaneously Hypertensive Rats (1980) (179)
- Angiotensin II receptors in normal and failing human hearts. (1989) (157)
- Cloning of the gene and cDNA for human heart chymase. (1991) (152)
- Collagen synthesis in development and reversal of cardiac hypertrophy in spontaneously hypertensive rats. (1979) (147)
- Renin in Rats with Spontaneous Hypertension (1972) (143)
- Synthesis and pharmacology of the octapeptide angiotonin. (1957) (135)
- Synthesis of a Biologically Active Octapeptide Similar to Natural Isoleucine Angiotonin Octapeptide1 (1957) (130)
- Angiotensinase with a High Degree of Specificity in Plasma and Red Cells (1963) (126)
- Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart. (1991) (122)
- Biochemical changes associated with development and reversal of cardiac hypertrophy in spontaneously hypertensive rats. (1976) (116)
- Angiotensin Tachyphylaxis and its Reversal (1966) (111)
- Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries. (1987) (111)
- Isolation of a phospholipid renin inhibitor from kidney. (1967) (99)
- Evidence for selective expression of angiotensin II receptors on atretic follicles in the rat ovary: an autoradiographic study. (1988) (94)
- Structure-Activity Relationship in Angiotensin II Analogs (1974) (94)
- Rat ovarian angiotensin II receptors. Characterization and coupling to estrogen secretion. (1987) (92)
- Separation and characterization of the protein moiety of human α1-lipoprotein (1958) (90)
- Angiotensins and the failing heart. Enhanced positive inotropic response to angiotensin I in cardiomyopathic hamster heart in the presence of captopril. (1990) (89)
- Inhibition of norepinephrine uptake in hearts by angiotensin II and analogs. (1969) (87)
- A New, Long-Lasting Competitive Inhibitor of Angiotensin (1972) (86)
- Reversal of cardiac hypertrophy in renal hypertensive rats: medical vs. surgical therapy. (1981) (84)
- The relationship of structure to pressor and oxytocic actions of isoleucine5 angiotensin octapeptide and various analogues (1961) (79)
- Use of Angiotensin II Antagonists in Experimental Hypertension (1973) (77)
- Angiotensin analogs: the influence of sarcosine substituted in position 1. (1974) (74)
- Measurement of angiotensin I converting enzyme inhibition in the heart. (1993) (74)
- Synthesis of some analogs of angiotensin II as specific antagonists of the parent hormone. (1972) (74)
- Failure sequence in solid-phase peptide synthesis due to the presence of an N-alkylamino acid. (1972) (71)
- Release of adrenal catecholamines by angiotensin I. (1971) (68)
- Lack of specific inhibition of angiotensin II in eels by angiotensin antagonists. (1978) (63)
- Antihypertensive effect of an isolated phospholipid. (1968) (63)
- A proposed conformation of isoleucyl5-angiotensin II (1962) (61)
- Analogs of angiotensin II. II. Mechanism of receptor interaction. (1970) (61)
- Regulation of angiotensin II receptors in cultured rat ovarian granulosa cells by follicle-stimulating hormone and angiotensin II. (1988) (59)
- DISTRIBUTION AND METABOLIC FATE OF ANGIOTENSIN II AND VARIOUS DERIVATIVES. (1964) (58)
- Synthesis of [alpha-methyltyrosine-4]angiotensin II: studies of its conformation, pressor activity, and mode of enzymatic degradation. (1981) (54)
- Role of Renin‐Angiotensin System in Chronic Renal Hypertensive Rats (1979) (53)
- A Naturally Occurring Renin Inhibitor (1967) (53)
- Characterization of angiotensin I-converting enzyme (ACE)-containing follicles in the rat ovary during the estrous cycle and effects of ACE inhibitor on ovulation. (1990) (52)
- The fifth scientific meeting of the interamerican society of hypertension, 1983 (1983) (50)
- Isolation of Aldosterone‐Stimulating Factor (ASF) and Its Effect on Rat Adrenal Glomerulosa Cells In Vitro (1981) (49)
- Angiotensin II: an intraovarian regulatory peptide. (1988) (49)
- Circular-dichroism spectra of truncated and other analogs of angiotensin II. (1976) (47)
- Cellular organization of the brain renin-angiotensin system. (1987) (45)
- Rat ovarian renin: characterization and changes during the estrous cycle. (1988) (45)
- Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals. (1977) (44)
- Identification of angiotensin II receptors in the rat ovary. (1986) (44)
- Amino acid side chain conformation in angiotensin II and analogs: correlated results of circular dichroism and 1H nuclear magnetic resonance. (1980) (44)
- Plasma renin activity in hypertensive rats after treatment with renin preinhibitor. (1969) (42)
- Angiotensin II: Its Metabolic Fate (1962) (42)
- A synthesis of cis-11-octadecenoic and trans-11-octadecenoic (vaccenic) acids. (1948) (41)
- Synthesis and evaluation of (Des-Asp1)angiotensin I as a precursor for (Des-Asp1)angiotensin II ("Angiotensin III"). (1975) (41)
- Competitive antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat ascending colon (1971) (41)
- Solubilisation of angiotensin II receptors in rabbit aortae membranes (1974) (39)
- Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa. (1988) (39)
- Pharmacologic Aspects of Synthetic Angiotonin (1957) (39)
- Studies on angiotensin II and analogs: impact of substitution in position 8 on conformation and activity. (1985) (38)
- Erythrocytosis in spontaneously hypertensive rats. (1972) (38)
- Action of (1-des(aspartic acid), 8-isoleucine) angiotensin II upon the pressor and steroidogenic activity of angiotensin II. (1975) (37)
- Regulation of Angiotensin II in Rat Adrenal Gland (1987) (37)
- Identification and synthesis of [1-asparagine, 5-valine, 9-glycine] angiotensin I produced from plasma of American eel Anguilla rostrata. (1985) (35)
- A Renin‐like Substance in the Human Placenta (1967) (34)
- Syntheses of an Optically Pure Tetrapeptide Contained in Angiotensin1,2 (1959) (34)
- Characterization of angiotensin receptors on bovine adrenal fasciculata cells. (1981) (34)
- Circular dichroism studies of angiotensin II and analogues: effects of primary sequence, solvent, and pH on the side-chain conformation. (1977) (33)
- Antagonism of peripheral and central effects of angiotensin II by (1-sarcosine, 8-isoleucine)angiotensin II. (1973) (33)
- Vascular and adrenocortical responses to a specific antagonist of angiotensin II. (1975) (32)
- The course of arterial pressure and the effect of Sar1-Thr8-angiotensin II in a new model of two-kidney hypertension in conscious dogs. (1977) (32)
- Analogs of angiotensin II. I. Solid phase synthesis. (1970) (31)
- Purification of angiotonin. (1945) (30)
- Idiopathic hyperaldosteronism. A possible role for aldosterone-stimulating factor. (1984) (30)
- Antagonists of Angiotensin II (1974) (29)
- Competitive binding activity of angiotensin II analogues in an adrenal cortex radioligand-receptor assay;. (1975) (29)
- Synthesis and Properties of Angiotonin (1958) (29)
- Isolation of a Hypertension‐Producing Compound from Normal Human Urine (1977) (29)
- Measurement of plasma renin substrate using homologous and heterologous renin. (1971) (29)
- Agonist and antagonist relationships in 1- and 8-substituted analogs of angiotensin II. (1974) (28)
- Angiotensin II: does it have a direct obligate role in ovulation? (1989) (28)
- Cardiac effects of angiotensin antagonists in normotensive rats. (1979) (27)
- Production of Renin by Human Juxtaglomerular Cells in Vitro (1966) (27)
- Localization, Purification, and Biological Activity of a New Aldosterone‐Stimulating Factor (1981) (26)
- Synthesis of Succinyl1-isoleucyl5-angiotensin II and N-(Poly-O-acetyl-seryl)-isoleucyl5-angiotensin II (1962) (26)
- An Improved Synthesis of Isoleucine5 Angiotensin Octapeptide1 (1961) (26)
- Chemical Assay of Phospholipid Renin Preinhibitor in Canine and Human Blood (1967) (25)
- Synthesis of [5-isoleucine, 8-alanine]-angiotensin II by the solution method synthesis and the solid-phase method synthesis. (1967) (24)
- Adrenal catecholamine response to haemorrhage abolished by an angiotensin antagonist. (1977) (24)
- Factors that influence the antagonistic properties of angiotensin II antagonists. (1973) (24)
- Interrelations between various blood pressure regulatory systems and the mosaic theory of hypertension. (1979) (23)
- A potent competitive antagonist of angiotensin II. (1972) (23)
- Lung Perfusion with Angiotensins I and II (1971) (22)
- Effects of SQ 20,881 on the Intact Kidney of Dogs With Two‐Kidney, One Clip Hypertension (1980) (22)
- Synthesis of [1-Isoleucine-, 3-proline-, and 5-alanine]-angiotensins. II. (1968) (21)
- Comparative receptor-binding properties of heptapeptide and octapeptide antagonists of angiotensin II in rat adrenal glomerulosa and uterine smooth muscle. (1980) (21)
- Solid-phase peptide synthesis of [L-alanine 3-L-isoleucine 5]-angiotensin II. (1967) (21)
- Effect of Synthetic Angiotonin on the Carotid Sinus (1957) (21)
- Partial Separation of an Oxytocic Principle from Preparations of Angiotonin (1956) (20)
- Irvine H. Page: 1901‐1991 The Celebration of a Leader (1991) (20)
- Isolation and amino acid composition of bradykinin released by venom of Bothrops jararaca from bovine plasma. (1961) (20)
- Angiotensin, the Renal Pressor Hormone (1961) (20)
- Conformation and activity in angiotensin II peptides (1981) (20)
- Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system. (1983) (20)
- Renin Production by Organ Cultures of Renal Cortex (1965) (19)
- Synthesis of angiotensin II analogues by incorporating beta-homotyrosine or beta-homoisoleucine residues. (1979) (18)
- Synthesis of Nonmammalian Angiotensins and Their Comparative Pressor Properties in Dogfish Shark, Domestic Chicken, and Rat (1983) (17)
- Experimental hypertensive disease of pregnancy. (1967) (17)
- Comparative studies of receptor binding and steroidogenic properties of angiotensins in the rat adrenal glomerulosa. (1979) (17)
- Steroidogenic Characteristics of a New Aldosterone‐Stimulating Factor (ASF) Isolated from Normal Human Urine (1981) (17)
- Synthesis of analogs of (8-isoleucine)angiotensin II with variations in position 1. (1974) (16)
- Influence of the adrenal gland on the pressor effect and antagonistic potency of angiotensin II analogs. (1975) (15)
- Development of two-kidney Goldblatt hypertension in rats under dietary sodium restriction. (1980) (15)
- Synthesis of angiotensin II antagonists by incorporating alpha-methylalanine or O-methylthreonine residues in angiotension II analogues. (1977) (15)
- The Chemistry of Antimycin A. II. Degradation Studies1 (1953) (15)
- Synthesis of Isoleucyl5-alanyl7-angiotensin II (1962) (14)
- Hypotensive effect of [Sar1,Thr8]angiotensin II in spontaneously hypertensive sodium-depleted rats. (1978) (14)
- pH titration effects on the cd spectra of angiotensin II, truncated peptides and other analogues: Aromatic region (1975) (14)
- In vitro steroidogenic properties of a new hypertension-producing compound isolated from normal human urine. (1980) (13)
- The renin-angiotensin system and treatment of heart failure. (1988) (13)
- In vitro and in vivo studies of (1-sarcosine, 8-threonine) angiotensin II. (1976) (13)
- Synthesis of angiotensin II antagonists containing N- and O-methylated and other amino acid residues. (1976) (13)
- Effects of Frog‐Skin Angiotensin II in Amphibians (1983) (13)
- Synthesis of Alanyl-isoleucyl-angiotensin II (1962) (13)
- Development and Preliminary Application of a New Assay for Aldosterone Stimulating Factor (1983) (12)
- BIOCHEMICAL ASPECTS OF THE RENIN-ANGIOTENSIN SYSTEM. (1965) (12)
- Angiotensin I and II Some Early Observations Made at The Cleveland Clinic Foundation and Recent Discoveries Relative to Angiotensin II Formation in Human Heart (1991) (12)
- Hierarchy of blood pressure control mechanisms after spinal sympathectomy. (1983) (12)
- Editorial: A Commentary on the Measurement of Renin and Angiotensin (1965) (12)
- Comparative studies of the humoral and arterial pressure responses to Sar1-Ala8-, Sar1-Ile8 and Sar1-Thr8-angiotensin II in the trained unanaesthetized dog. (1976) (11)
- Spontaneous Hypertension and Erythrocytosis in Rats (1972) (11)
- Solid-phase synthesis of (6-arginine)-, (4-histidine, 6-tyrosine)-, and (8-isoleucine)angiotensins II. (1972) (11)
- Biochemical and immunological properties of dog brain isorenin. (1984) (11)
- Efficacy of octa- and heptapeptide antagonists of angiotensin II as inhibitors of angiotensin III binding in the rat adrenal glomerulosa. (1985) (11)
- Apparatus for Solid-Phase Peptide Synthesis (1967) (11)
- Alteration in the feedback control of renin release by an angiotensin antagonist. (1974) (10)
- Renin in experimental "toxemia of pregnancy". (1967) (10)
- Biological activity of des-asp1-des-arg2-angiotensin II in man. (1982) (10)
- Phospholipase A2 in experimental hypertension. (1975) (10)
- Synthesis and specific pressor activity of [1-aspartic acid,5-valine,9-serine]angiotensin I ("fowl angiotensin I"). (1977) (10)
- Serotonin and its methylated derivatives in human urine. (1955) (10)
- Differential effects of Asp-angiotensin II and Sar-angiotensin II on vascular and adrenal receptors in the dog. (1976) (9)
- Importance of Amino Acid Side Groups for Biologic Activity of Angiotensin II (1962) (9)
- Synthesis of ala-pro-gly-[Ile3, Val5]angiotensin II isolated from the skin of the australian frog Crinia georgiana. (1981) (9)
- Inhibition of the pressor and aldosterone-releasing effects of angiotensin II. (1975) (9)
- Angiotensin Antagonist and Possible Release of Catecholamine (1974) (9)
- Synthesis of [1-sarcosine, 8-O-methylserine]angiotensin II and 1-substituted analogues of [8-threonine]angiotensin II as antagonists of angiotensin II. (1977) (8)
- Steroidogenic and pressor activity of angiotensin analogues in the rat. (1978) (8)
- Effects of angiotensin antagonists in various forms of experimental arterial hypertension. (1976) (8)
- Steroidogenic properties of a new aldosterone-stimulating factor: interaction with angiotensin II and adrenocorticotropin during variations of dietary sodium. (1984) (8)
- Mechanisms and sites of action of newer angiotensin agonists and antagonists in terms of activity and receptor. (1977) (8)
- A new short-acting antagonist of angiotensin II. (1973) (7)
- Solid-phase synthesis of (3-proline,8-isoleucine)-,(1-sarcosine,3-proline,8-isoleucine)-, and (4-phenylalanine,8-isoleucine)angiotensin II as the antagonists of the parent hormone. (1973) (7)
- Angiotensinase activity in red blood cell membranes and intact adrenal cells. (1977) (7)
- Unitage and Suggested Designation of Angiotensin Activity (1962) (7)
- Identity of Synthetic trans-11-Octadecenoic Acid (1950) (7)
- Glucocorticoid hypersecretion and hypertensive vascular disease in experimental malignant hypertension in rats (1982) (6)
- Localization of angiotensin receptors in the canine CNS. (1984) (6)
- Separation and characterization of the protein moiety of human alpha1-lipoprotein. (1958) (6)
- A cardiac specific analog of angiotensin I potentiated by converting enzyme inhibition. (1985) (6)
- Quantitative studies of renin preinhibitor and total phospholipids in organs and in plasma and erythrocytes to control, nephrectomized, and very old rats. (1969) (5)
- The purification of hog renin substrate. (1954) (5)
- Isorenin in dog brain and other tissues. (1984) (5)
- Differing patterns of altered glucocorticoid secretion in experimental malignant and benign hypertension. Influences upon the lymphoid system and on arterial connective tissue metabolism (1983) (5)
- Comparison of octa- and heptapeptide antagonists of angiotensin II as inhibitors of angiotensin II-induced steroidogenesis in the rat adrenal glomerulosa. (1981) (5)
- A hypertensive macromolecule from human urine. (1974) (5)
- Characterization of receptors for angiotensin-induced drinking and blood pressure responses in conscious rats using angiotensin analogs extended at the N-terminal. (1986) (5)
- Identification of a pressor polypeptide in human amniotic fluid. (1971) (4)
- A proposed conformation of isoleucyl-5-angiotensin II. (1962) (4)
- Cutaneous tubeless ureterostomy as a procedure to study renal function in conscious dogs. (1978) (4)
- Angiotensin Antagonists in Relation to Hypertension (1974) (4)
- Tritiated Angiotensin: Preparation and Purification (1966) (3)
- The hormone angiotensin: a chemical and pharmacologic survey. (1962) (3)
- Effect of mercuric chloride on plasma renin substrate level in rats. (1972) (3)
- SYNTHESIS OF ANGIOTENSIN II ANTAGONISTS BY INCORPORATING α-METHYLALANINE OR O-METHYLTHREONINE RESIDUES IN ANGIOTENSIN II ANALOGS (1977) (3)
- New approaches to the study of angiotensin tachyphylaxis. (1977) (3)
- Effect of urea and amino acids on angiotensin interaction with smooth muscle. (1965) (3)
- AGONIST AND ANTAGONIST RELATIONSHIPS IN 1- AND 8-SUBSTITUTED ANALOGS OF ANGIOTENSIN II (1975) (2)
- Angiotensin Analogues That Selectively Augment the Force of Contraction of the Isolated Heart (1988) (2)
- Competitive inhibition of Asp1‐β‐amide‐Val5‐angiotensin II by Sar1‐Ile5‐Ile8‐angiotensin II in cat isolated cardiac muscle and coronary vessels * (1974) (2)
- Selective Pharmacological Effects of Triprolyl and Pentasarcosyl Angiotensin II (1987) (2)
- Renin "preinhibitor" in blood of anephric patients, in a case of hypobetalipoproteinemia, and evidence of its major association with plasma alpha lipoproteins. (1969) (2)
- Extended forms of brain angiotensins and other peptide hormones. (1984) (2)
- SYNTHESIS OF (1-SARCOSINE,8-O-METHYLSERINE)ANGIOTENSIN II AND 1-SUBSTITUTED ANALOGS OF (8-THREONINE)ANGIOTENSIN II AS ANTAGONISTS OF ANGIOTENSIN II (1977) (1)
- Pathogenic factors involved in renovascular hypertension. State of the art. (1977) (1)
- Synthesis of isoleucine-5-tyrosine-8-angiotensin II and isoleucine-5-hydroxyproline-7-angiotensin II. (1966) (1)
- Preliminary Studies on the Structure of Angiotonin. (1954) (1)
- Biological Activity of Angiotensin II-(4-8)-Pentapeptide in Man (1982) (1)
- Extrarenal Renin-Angiotensin System: Comments on its Occurrence and Cardiovascular Role (1984) (1)
- Effects of angiotensin I of the American bullfrog Rana catesbeiana on amphibian tissues. (1993) (1)
- Characterization of Angiotensin I in Turtle Plasma (1986) (1)
- SYNTHESIS OF ANGIOTENSIN II ANTAGONISTS CONTAINING N- AND O-METHYLATED AND OTHER AMINO ACID RESIDUES (1976) (1)
- New aspects of aldosterone regulation. (1977) (1)
- Lung Perfusion with Angiotensins I and II: Evidence of Release of Myotropic and Inhibitory Substances (1971) (1)
- SYNTHESIS AND SPECIFIC PRESSOR ACTIVITY OF (1-ASPARTIC ACID, 5-VALINE, 9-SERINE)ANGIOTENSIN I (′FOWL AND ANGIOTENSIN I′) (1977) (1)
- SYNTHESIS OF ALA-PRO-GLY-(ILE3,VAL5)ANGIOTENSIN II ISOLATED FROM THE SKIN OF THE AUSTRALIAN FROG CRINIA GEORGIANA (1981) (1)
- Luminescent properties of Angiotensin II and its analogues (1973) (0)
- Circulation Research provides a medium for bringing together basic research on the cardiovascular sys- tem from various disciplines including biology, biochemistry, biophysics, morphology, pathology, physiology, and pharmacology. The Journal also will accept for publication manuscripts on clinical r (1977) (0)
- A novel angiotensin II-forming pathway in the human heart (1992) (0)
- [Therepeutic effect of an angiotensin II antagonist in experimental malignant nephrosclerosis]. (1976) (0)
- ANALOGA DES ANGIOTENSINS II 1. MITT. SYNTH. AN FESTER PHASE (1970) (0)
- Renal hypertension. (1967) (0)
- Estimating endogenous renin. (1968) (0)
- Central actions of circulating angiotensin II on the sympathetic nervous system and blood pressure control. (1985) (0)
- Synthesis of(a-methyltyrosin e-4)angiotensin II:Studies ofits conformation, pressor activity, andmodeofenzymatic degradation (1981) (0)
- Irvine Heinly Page, MD (1901–1991) (1991) (0)
- Competative antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat colon. (1971) (0)
- Studies on Experimental Hypertension Using Blockers of Renin, Converting Enzyme, and Angiotensin II (1981) (0)
- BRIEF COMMUNICATIONS Evidence for the Existence of a Family of Biologically Active Angiotensin I-Like Peptides in the Dog Central Nervous System (2005) (0)
- SYNTHESIS OF ANALOGS OF (8-ISOLEUCINE)ANGIOTENSIN II WITH VARIATIONS IN POSITION 1 (1974) (0)
- SOLID-PHASE SYNTHESIS OF (3-PROLINE, 8-ISOLEUCINE)-, (1-SARCOSINE, 3-PROLINE, 8-ISOLEUCINE)- AND (4-PHENYLALANINE, 8-ISOLEUCINE)ANGIOTENSIN II AS THE ANTAGONISTS OF THE PARENT HORMONE (1974) (0)
- A tribute to Robert C. Tarazi, M.D. (1925–1986) (1989) (0)
- Summary of Discussions (1972) (0)
- SYNTHESIS OF ANGIOTENSIN II ANALOGS BY INCORPORATING β-HOMOTYROSINE OR β-HOMOISOLEUCINE RESIDUES (1980) (0)
- Proceedings: Structural activity requirements for the action of angiotensin II on fluid transport by rat jejunum. (1976) (0)
- IBCALIZATION OF ANGIOTENSM RECEPTORS IN THE CANME CNS (1985) (0)
- FACTORS THAT INFLUENCE THE ANTAGONISTIC PROPERTIES OF ANGIOTENSIN II ANTAGONISTS (1973) (0)
- Importance of Residue 5 in Antiotensin II (1983) (0)
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