Fuad N. Ziyadeh
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Fuad N. Ziyadehbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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#1981
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Biology
Fuad N. Ziyadeh's Degrees
- PhD Biochemistry University of California, San Francisco
- Masters Molecular Biology Stanford University
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)Fuad N. Ziyadeh's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. (2000) (1082)
- Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. (2000) (928)
- Leptin and renal disease. (2002) (652)
- Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. (1994) (615)
- Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice (1996) (615)
- From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. (2005) (561)
- Molecular mechanisms of diabetic renal hypertrophy. (1999) (480)
- Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. (2002) (477)
- Mediators of Diabetic Renal Disease: The Case for TGF-β as the Major Mediator (2004) (418)
- Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. (1993) (378)
- Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. (2008) (377)
- High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β (1992) (348)
- Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis1 (1999) (335)
- Elevated glucose stimulates TGF-beta gene expression and bioactivity in proximal tubule. (1992) (303)
- Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes (1997) (283)
- The emerging role of transforming growth factor-beta in kidney diseases. (1994) (276)
- The extracellular matrix in diabetic nephropathy. (1993) (270)
- Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. (1997) (264)
- Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. (2003) (255)
- Cellular and Molecular Mechanisms of Proteinuria in Diabetic Nephropathy (2007) (248)
- The role of angiotensin II in diabetic nephropathy: emphasis on nonhemodynamic mechanisms. (1997) (234)
- Hydrogen peroxide increases extracellular matrix mRNA through TGF-beta in human mesangial cells. (2001) (226)
- High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. (1990) (222)
- Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator. (2004) (216)
- Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. (2002) (214)
- Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse. (1994) (212)
- Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. (2006) (200)
- Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. (1997) (196)
- Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. (2001) (191)
- Leptin and renal fibrosis. (2006) (182)
- Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. (2002) (175)
- Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients. (1999) (170)
- Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration. (1998) (166)
- Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy. (1995) (157)
- Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression. (2001) (146)
- High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-beta. (1999) (146)
- Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis [seecomments]. (1999) (144)
- The urine/plasma electrolyte ratio: a predictive guide to water restriction. (2000) (143)
- Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. (2003) (136)
- Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: involvement of the transforming growth factor-beta system. (1998) (132)
- Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells. (2000) (126)
- Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels: possible mediation via protein kinase C. (1995) (126)
- Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. (2000) (119)
- Amadori glucose adducts modulate mesangial cell growth and collagen gene expression. (1994) (117)
- Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells. (2001) (113)
- Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test. (2005) (111)
- Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. (2007) (111)
- F(2)-isoprostanes mediate high glucose-induced TGF-beta synthesis and glomerular proteinuria in experimental type I diabetes. (2000) (111)
- Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy. (1997) (110)
- High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy. (1997) (108)
- Podocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes. (2004) (105)
- PKC and high glucose stimulate collagen alpha 1 (IV) transcriptional activity in a reporter mesangial cell line. (1994) (102)
- Renal tubular basement membrane and collagen type IV in diabetes mellitus. (1993) (100)
- Glomerular expression of p27Kip1 in diabetic db/db mouse: role of hyperglycemia. (1998) (97)
- THE KEY ROLE OF THE TRANSFORMING GROWTH FACTOR-β SYSTEM IN THE PATHOGENESIS OF DIABETIC NEPHROPATHY (2001) (96)
- Angiotensin II stimulates α3(IV) collagen production in mouse podocytes via TGF-β and VEGF signalling: implications for diabetic glomerulopathy (2005) (92)
- Angiotensin II is mitogenic for cultured rat glomerular endothelial cells. (1996) (92)
- Overview: combating diabetic nephropathy. (2003) (89)
- Angiotensin II stimulates expression of transforming growth factor β receptor type II in cultured mouse proximal tubular cells (1999) (88)
- Uremia induces functional incompetence of bone marrow-derived stromal cells. (2012) (86)
- Role of Amadori-modified nonenzymatically glycated serum proteins in the pathogenesis of diabetic nephropathy. (1996) (86)
- The utility of the transtubular potassium gradient in the evaluation of hyperkalemia. (2008) (84)
- Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease. (1992) (81)
- Amadori-glycated albumin in diabetic nephropathy: pathophysiologic connections. (2000) (79)
- The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture. (1991) (76)
- Estradiol reverses TGF-β1-stimulated type IV collagen gene transcription in murine mesangial cells. (1998) (76)
- Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney. (2000) (74)
- Different roles for TGF-beta and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy. (2008) (74)
- The renal tubulointerstitium in diabetes mellitus. (1991) (73)
- Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications. (2006) (73)
- Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells. (2004) (71)
- TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy. (2001) (70)
- Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor (2012) (69)
- The transforming growth factor-beta system and the kidney. (1993) (68)
- High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. (1992) (68)
- Evolution of renal function abnormalities in the db/db mouse that parallels the development of human diabetic nephropathy. (1996) (67)
- Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. (2005) (66)
- Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: attenuation after stable transfection with the c-mas oncogene. (1995) (65)
- Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose. (1991) (65)
- Significance of tubulointerstitial changes in diabetic renal disease. (1996) (64)
- Serum-stimulated α1 type IV collagen gene transcription is mediated by TGF-β and inhibited by estradiol. (1998) (62)
- Renal tubular hypertrophy induced by angiotensin II. (1997) (62)
- Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule. (1994) (62)
- Hypotonicity and cell volume regulation in shark rectal gland: role of organic osmolytes and F-actin. (1992) (59)
- Potential Role of TGF-β in Diabetic Nephropathy (1998) (59)
- Role of transforming growth factor-beta in diabetic glomerulosclerosis and renal hypertrophy. (1995) (58)
- Retinoids as a potential treatment for experimental puromycin‐induced nephrosis (2003) (58)
- Role of transforming growth factor beta in diabetic nephropathy. (1994) (56)
- Glycated albumin stimulation of PKC-β activity is linked to increased collagen IV in mesangial cells. (1999) (56)
- Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats (1999) (55)
- Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy. (2005) (53)
- 20-HETE and EETs in Diabetic Nephropathy: A Novel Mechanistic Pathway (2013) (51)
- Overview of the physiology and pathophysiology of leptin with special emphasis on its role in the kidney. (2013) (49)
- ANG II is a mitogen for a murine cell line isolated from medullary thick ascending limb of Henle's loop. (1995) (47)
- Taurine Intestinal Absorption and Renal Excretion Test in Diabetic Patients (2007) (45)
- The cardiorenal syndrome in diabetes mellitus. (2010) (45)
- The Renal TGF-β System in the db/db Mouse Model of Diabetic Nephropathy (1998) (45)
- Angiotensin II stimulates expression of transforming growth factor beta receptor type II in cultured mouse proximal tubular cells. (1999) (43)
- Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose. (1998) (43)
- Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells. (2002) (42)
- Involvement of transforming growth factor-beta and its receptors in the pathogenesis of diabetic nephrology. (1997) (41)
- Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. (2012) (37)
- Glomerular Hyperfiltration and Proteinuria in Transfusion-Independent Patients with β-Thalassemia Intermedia (2012) (37)
- Inhibiting Albumin Glycation Ameliorates Diabetic Nephropathy in the db/db Mouse (2000) (36)
- Angiotensin II Induces α3(IV) Collagen Expression in Cultured Murine Proximal Tubular Cells (1999) (36)
- Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen α1 (IV) in glomerular mesangial cells (1995) (34)
- Update on pathogenesis, markers and management of diabetic nephropathy. (1996) (33)
- Role of insulin and IGF1 receptors in proliferation of cultured renal proximal tubule cells. (1992) (32)
- Vascular endothelial growth factor and diabetic nephropathy (2008) (32)
- Effects of glycated albumin on mesangial cells: evidence for a role in diabetic nephropathy (1993) (32)
- Angiotensin II inhibits inducible nitric oxide synthase in tubular MCT cells by a posttranscriptional mechanism. (1997) (31)
- Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. (2004) (31)
- Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (2000) (30)
- Antioxidant treatment induces transcription and expression of transforming growth factor β in cultured renal proximal tubular cells (2001) (30)
- Mediators of hyperglycemia and the pathogenesis of matrix accumulation in diabetic renal disease. (1995) (28)
- Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1. (2002) (27)
- Hepatocyte growth factor: a regulator of extracellular matrix genes in mouse mesangial cells. (2000) (27)
- Atrial natriuretic peptide stimulates the expression of transforming growth factor-beta in cultured murine mesangial cells: relationship to suppression of proliferation. (1995) (25)
- Utility of Serum and Urinary Transforming Growth Factor-Beta Levels as Markers of Diabetic Nephropathy (2000) (25)
- GLUT1 and TGF-beta: the link between hyperglycaemia and diabetic nephropathy. (1999) (25)
- Cyclosporin A induces transcription of transforming growth factor beta in a cultured murine proximal tubular cell line. (1996) (25)
- Potential role of TGF-beta in diabetic nephropathy. (1998) (25)
- Taurine and cell volume maintenance in the shark rectal gland: cellular fluxes and kinetics. (1988) (24)
- The renal TGF-beta system in the db/db mouse model of diabetic nephropathy. (1998) (23)
- Propionate induces cell swelling and K+ accumulation in shark rectal gland. (1989) (23)
- Growth arrest of a murine mesangial cell line by transforming growth factor beta 1 is associated with inhibition of mitogen-induced Ca2+ mobilization. (1995) (22)
- A 5-year survey of biopsy proven kidney diseases in Lebanon: significant variation in prevalence of primary glomerular diseases by age, population structure and consanguinity. (2010) (22)
- Estradiol reverses TGF-beta1-stimulated type IV collagen gene transcription in murine mesangial cells. (1998) (22)
- Albumin modified by Amadori glucose adducts activates mesangial cell type IV collagen gene transcription (1995) (22)
- What is the role of decorin in diabetic kidney disease? (1999) (21)
- Effects of weight reduction regimens and bariatric surgery on chronic kidney disease in obese patients. (2013) (20)
- Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells. (1999) (19)
- pCMBS-induced swelling of dogfish (Squalus acanthias) rectal gland cells: role of the Na+,K(+)-ATPase and the cytoskeleton. (1990) (17)
- Global Renal Gene Expression Profiling Analysis in B2-Kinin Receptor Null Mice: Impact of Diabetes (2012) (17)
- The diabetic renal tubulointerstitium. (1995) (16)
- Diabetic kidney disease research: where do we stand at the turn of the century? (2000) (16)
- Emerging Therapies for Diabetic Nephropathy Patients: Beyond Blockade of the Renin-Angiotensin System (2012) (16)
- Early and advanced non-enzymatic glycation products in the pathogenesis of diabetic kidney disease. (1997) (16)
- The renin-angiotensin system in diabetic nephropathy. (2001) (15)
- Proteome profiling in the aorta and kidney of type 1 diabetic rats (2017) (14)
- THE ROLE OF ANGIOTENSIN II IN DIABETIC (1997) (13)
- Glycated albumin modified by amadori adducts modulates aortic endothelial cell biology (1995) (13)
- Role of protein kinase C and cyclic AMP/protein kinase A in high glucose-stimulated transcriptional activation of collagen alpha 1 (IV) in glomerular mesangial cells. (1995) (13)
- Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells. (1999) (12)
- Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C. (1998) (12)
- Thiazides stimulate calcium absorption in urinary bladder of winter flounder. (1987) (12)
- RAGE mRNA expression in the diabetic mouse kidney (1997) (11)
- Bartter's syndrome: a unifying hypothesis. (1985) (11)
- Serum-stimulated alpha 1 type IV collagen gene transcription is mediated by TGF-beta and inhibited by estradiol. (1998) (11)
- Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose. (1998) (9)
- Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells (2019) (9)
- Angiogenic factors. (2011) (9)
- Pathophysiology and Pathogenesis of Diabetic Nephropathy (2013) (8)
- Facilitative glucose transport proteins and sodium-glucose co-transporters in the kidney. (1995) (8)
- Hormones, autacoids, and the kidney (1992) (7)
- Perspectives in Diabetes Hyperglycemia and Diabetic Kidney Disease The Case for Transforming Growth Factor-P as a Key (1995) (7)
- Relationships between calcium and chloride transport in frog skin glands. (1986) (7)
- Regulation of Inducible Class II MHC, Costimulatory Molecules, and Cytokine Expression in TGF-β1 Knockout Renal Epithelial Cells: Effect of Exogenous TGF-β1 (2002) (7)
- The use of neutralizing antibodies to demonstrate the role of transforming growth factor-beta and Amadori-glycated albumin as mediators of experimental diabetic kidney disease. (1996) (6)
- Modulation of proteomic and inflammatory signals by Bradykinin in podocytes (2020) (6)
- End stage renal disease in six patients with beta-thalassemia intermedia. (2013) (6)
- Why should an angiogenic factor modulate tubular structure in diabetic nephropathy? Some answers, more questions. (2003) (5)
- Diabetes and hypertension. Australian Diabetes Society position statement (1996) (5)
- Role of calcium in chloride-secreting epithelia. (1988) (4)
- cAMP- and beta-adrenergic-stimulated chloride-dependent Ca2+ secretion in frog skin. (1985) (4)
- stable transfection with the c-mas oncogene (1995) (4)
- The role of growth factors in the development of diabetic nephropathy (1996) (4)
- Benzodiazepines stimulate sodium ion transport in frog skin epithelium. (1988) (4)
- IN-DEPTH REVIEWS Leptin and Renal Disease (2002) (3)
- Transforming growth factor- and diabetic nephropathy (2009) (3)
- Benzodiazepines inhibit transport-related oxygen consumption in thick ascending limb. (1988) (3)
- Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals (2020) (3)
- Transforming Growth Factor-β and other Cytokines in Experimental and Human Nephropathy (1998) (3)
- Growth factors in the pathogenesis of diabetic nephropathy (2011) (3)
- Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes. (2015) (2)
- The urine/plasma electrolyte ratio (2000) (2)
- CHAPTER 78 – Pathophysiology and Pathogenesis of Diabetic Nephropathy (2008) (2)
- Involvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy (2002) (2)
- Mechanisms of calcium transport in the thick ascending limb of the loop of Henle. (1986) (2)
- [Current issues in the diagnosis and therapy of diabetic nephropathy]. (1997) (2)
- Pathophysiology of Diabetic Nephropathy (2020) (2)
- Glomerular lesions and microalbuminuria in diabetes. (1989) (1)
- New Clothes for the Emperor (2002) (1)
- Management of Diabetic Nephropathy (2009) (1)
- Transforming Growth Factor-β Signal Transduction in the Pathogenesis of Diabetic Nephropathy (2006) (1)
- Fractional excretion of chloride in prerenal azotemia. (1985) (1)
- A novel mechanistic pathway linking diabetes to colorectal cancer: Role of AMPK and mTOR (2012) (0)
- Contents Vol. 10, 2002 (2002) (0)
- Contents Vol. 121, 2012 (2013) (0)
- TRANSFORMING GROWTH FACTOR 1 (TGF-P) IN PROXIMAL TUBULE CELLS (PTC): PRODUCTION, GLUCOSE - INDUCED TRANSCRIPTIONAL CONTROL AND AUTOCRINE ROLE IN CELL PROLIFERATION (1990) (0)
- Characteristics of Pulmonary Arteriovenous Malformation in Non-Hereditary Hemorrhagic Telangiectasia; a Population-Based Study (2021) (0)
- Announcements – Book Review (2000) (0)
- Subject Index Vol. 10, 2002 (2002) (0)
- Diabetes Mellitus: Is the Presence of Nephropathy Important as a Cardiovascular Risk Factor for Cardioneral Syndrome? (2010) (0)
- AFLUID May 45/5 (1999) (0)
- Prevalence, Predicators and Impact of Primary Immunodeficiency in Adults with Asthma; A Population-Based Study (2021) (0)
- Treatment of the Patient with End‐Stage Diabetic Nephropathy (2012) (0)
- VEGF-A: A NOVEL MECHANISTIC LINK BETWEEN CYP2C-DERIVED EET AND NOX4 IN DIABETIC KIDNEY DISEASE. (2023) (0)
- Steroid treatment of drug-induced acute interstitial nephritis. (2008) (0)
- Inhibition of F2-isoprostane synthesis reduces proteinuria and improves renal function in streptozotocin (STZ)-induced diabetic rats (1999) (0)
- Correction to: Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-b type II receptor (2021) (0)
- [Current questions concerning the pathomechanism of diabetic nephropathy]. (1996) (0)
- The TGF-beta system mediates some of the high glucose effects on differentiated mouse podocytes (2002) (0)
- Structural and Functional Consequences of Streptozotocin-Induced Diabetes on the Kidney (2018) (0)
- collagen gene expression (1994) (0)
- High glucose (HG)-induced synthesis of transforming growth factor β (TGF-β) in glomerular cells is driven by F2-isoprostane formation (1999) (0)
- TGF-jl: A CRUCIAL COMPONENT OF THE PATHOGENESIS OF DIABETIC NEPHROPATHY (2007) (0)
- Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris (2021) (0)
- 75 VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING BLOCKADE AMELIORATES DIABETIC ALBUMINURIA IN MICE: EFFECTS ON THE KIDNEY PODOCYTE. (2007) (0)
- Correction to: Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-b type II receptor. (2022) (0)
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