F. Peter Guengerich

F. Peter Guengerich's AcademicInfluence.com Rankings

F. Peter Guengerich

Biology

#776

World Rank

#1343

Historical Rank

Biochemistry

#45

World Rank

#59

Historical Rank

biology Degrees

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Biology

F. Peter Guengerich's Degrees

PhD Biochemistry University of California, San Francisco
Bachelors Chemistry University of California, Berkeley

Why Is F. Peter Guengerich Influential?

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According to Wikipedia, Frederick Peter Guengerich is a professor of biochemistry and the director of the Center in Molecular Toxicology at Vanderbilt University, Nashville, Tennessee. Guengerich is the author or co-author of over 500 peer-reviewed scientific articles, and a researcher in toxicology working on cytochromes P450, DNA damage and carcinogenesis, and drug metabolism. In 2005 he received the William C. Rose Award for his research.

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F. Peter Guengerich's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. (1994) (2898)
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. (1993) (1640)
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. (2001) (1485)
Cytochrome p450 and chemical toxicology. (2008) (1402)
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. (1991) (1237)
Cytochrome P-450 3A4: regulation and role in drug metabolism. (1999) (1231)
Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. (1997) (1200)
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. (1991) (1056)
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008) (1040)
Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. (1991) (1037)
Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone. (1982) (924)
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. (1996) (832)
Summary of information on human CYP enzymes: human P450 metabolism data (2002) (789)
The P450 gene superfamily: recommended nomenclature. (1987) (774)
Human cytochrome P-450 enzymes. (1992) (771)
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. (1986) (743)
Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. (1989) (668)
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. (1985) (646)
Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. (1985) (574)
Cytochrome P450s and other enzymes in drug metabolism and toxicity (2006) (561)
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. (1989) (552)
Reactions and significance of cytochrome P-450 enzymes. (1991) (541)
Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. (1988) (485)
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). (1990) (451)
Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. (1988) (439)
Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. (1982) (421)
Chemical mechanisms of catalysis by cytochromes P-450: a unified view (1984) (406)
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1 (1990) (404)
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. (1993) (399)
Complex reactions catalyzed by cytochrome P450 enzymes. (2007) (387)
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. (1992) (385)
Cytochromes P450, drugs, and diseases. (2003) (383)
Cooperativity in oxidations catalyzed by cytochrome P450 3A4. (1997) (382)
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. (1992) (380)
Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. (1993) (349)
Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. (1997) (346)
Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. (2000) (332)
Enzymatic activation of chemicals to toxic metabolites. (1985) (323)
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. (1989) (321)
Genetic polymorphism of S-mephenytoin hydroxylation. (1989) (317)
Characterization of human cytochrome P450 enzymes (1992) (315)
Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. (1994) (311)
Oxidation of quinidine by human liver cytochrome P-450. (1986) (311)
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. (1985) (308)
Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase (2009) (307)
Activation and detoxication of aflatoxin B1. (1998) (299)
Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest. (1977) (299)
Catalytic properties of polymorphic human cytochrome P450 1B1 variants. (1999) (292)
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. (1989) (285)
Drug metabolism by Escherichia coli expressing human cytochromes P450 (1997) (282)
Elucidating mechanisms of drug-induced toxicity (2005) (276)
Purification and characterization of human liver microsomal cytochrome P-450 2A6. (1991) (273)
Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. (1995) (271)
Role of cytochrome P450 enzymes in drug-drug interactions. (1997) (270)
Oxidation of indole by cytochrome P450 enzymes. (2000) (268)
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs. (1996) (267)
Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene. (1990) (267)
Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. (1991) (266)
Activation of procarcinogens by human cytochrome P450 enzymes. (1998) (266)
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. (1991) (265)
Metabolism of chemical carcinogens. (2000) (264)
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals (2014) (263)
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals (2014) (263)
Characterization of human microsomal cytochrome P-450 enzymes. (1989) (258)
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. (1990) (258)
Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. (1992) (256)
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. (2010) (255)
Unusual Cytochrome P450 Enzymes and Reactions* (2013) (255)
Enzymatic oxidation of xenobiotic chemicals. (1990) (253)
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. (1991) (247)
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. (2002) (245)
Resveratrol is a selective human cytochrome P450 1A1 inhibitor. (1999) (243)
Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. (1986) (241)
Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. (1992) (239)
Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. (1989) (233)
Cytochrome P450 activation of arylamines and heterocyclic amines. (2005) (229)
Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. (1993) (229)
Mechanisms of drug toxicity and relevance to pharmaceutical development. (2011) (228)
Elucidation of distinct ligand binding sites for cytochrome P450 3A4. (2000) (221)
Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450. (1988) (220)
Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. (2001) (219)
Selective inhibitors of cytochromes P450. (1994) (214)
Contributions of human enzymes in carcinogen metabolism. (2012) (214)
Contributions of human enzymes in carcinogen metabolism. (2012) (214)
Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. (1982) (210)
Mechanisms of cytochrome P450 substrate oxidation: MiniReview (2007) (210)
Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats. (1978) (209)
Cytochrome p450 enzymes in the generation of commercial products (2002) (209)
Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes. (1980) (208)
Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. (1995) (207)
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. (1990) (205)
Metabolic activation of carcinogens. (1992) (204)
Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. (1998) (203)
Recent Structural Insights into Cytochrome P450 Function. (2016) (202)
Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. (1995) (201)
Cytochrome P450: what have we learned and what are the future issues? (2004) (199)
Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system. (1980) (197)
Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes. (1991) (195)
Lack of Electron Transfer from Cytochrome b5 in Stimulation of Catalytic Activities of Cytochrome P450 3A4 (1996) (195)
Applying mechanisms of chemical toxicity to predict drug safety. (2007) (194)
Isolation and purification of cytochrome P-450, and the existence of multiple forms. (1979) (191)
Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes. (1983) (190)
Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. (1994) (189)
Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. (1998) (188)
Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. (2006) (185)
Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. (1990) (185)
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. (1993) (185)
Interaction of ranitidine with liver microsomes. (1979) (183)
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. (1993) (183)
Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis (2017) (180)
Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. (1992) (180)
Mechanisms of cytochrome P‐450 catalysis (1990) (179)
Polymorphism of human cytochrome P-450. (1987) (176)
Expression of cytochrome P-450 enzymes in cultured human hepatocytes. (1990) (174)
Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. (1998) (174)
Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. (1997) (171)
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450. (1982) (168)
Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions. (2003) (167)
Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems. (1997) (167)
Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. (1989) (166)
Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. (1998) (165)
DNA adduction by the potent carcinogen aflatoxin B1 : mechanistic studies (1994) (161)
Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity. (1994) (161)
Mechanisms of Cytochrome P450-Catalyzed Oxidations. (2018) (160)
Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. (1999) (159)
Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis. (1996) (159)
Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. (1995) (158)
Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. (1986) (157)
Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers. (2004) (156)
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies. (2003) (156)
Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. (1999) (155)
Identification of Human Liver Cytochrome P-450 3A4 as the Enzyme Responsible for Fentanyl and Sufentanil N-Dealkylation (1996) (154)
Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine. (1991) (154)
Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases. (1985) (154)
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. (1986) (154)
In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. (1980) (152)
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. (1993) (148)
Purification and characterization of microsomal cytochrome P-450s. (1982) (148)
Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. (1990) (146)
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction (2006) (145)
Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism. (1984) (144)
Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450. (1983) (143)
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations. (1997) (142)
An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats. (1981) (142)
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. (2001) (141)
DNA Adduct Bypass Polymerization by Sulfolobus solfataricus DNA Polymerase Dpo4 (2005) (141)
Cytochromes P-450 in human hepatocyte plasma membrane: recognition by several autoantibodies. (1993) (141)
Metabolism of N-nitrosodialkylamines by human liver microsomes. (1988) (140)
Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling. (1985) (139)
In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetic models. (1989) (138)
Formation of indigo by recombinant mammalian cytochrome P450. (1999) (137)
Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. (1994) (137)
Kinetics and Thermodynamics of Ligand Binding by Cytochrome P450 3A4* (2006) (137)
Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. (1997) (136)
Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition. (1987) (136)
Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations. (1996) (136)
Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. (1983) (135)
Function of human cytochrome P450s: characterization of the orphans. (2005) (135)
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. (1992) (135)
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. (1997) (133)
Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. (1997) (133)
Binding of Two Flaviolin Substrate Molecules, Oxidative Coupling, and Crystal Structure of Streptomyces coelicolor A3(2) Cytochrome P450 158A2* (2005) (132)
Metabolism of 17 α-ethynylestradiol in humans (1990) (131)
Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. (1996) (131)
Translesion Synthesis across Bulky N2-Alkyl Guanine DNA Adducts by Human DNA Polymerase κ* (2006) (129)
Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates. (1995) (129)
Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants. (2000) (129)
Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes (1996) (129)
Formation and Cleavage of C-C Bonds by Enzymatic Oxidation-Reduction Reactions. (2018) (128)
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. (1989) (128)
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. (1992) (128)
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. (1989) (128)
Kinetics of Cytochrome P450 2E1-Catalyzed Oxidation of Ethanol to Acetic Acid via Acetaldehyde* (1999) (126)
Immunological comparison of hepatic and extrahepatic cytochromes P-450. (1979) (124)
Cytochromes P450 and drug discovery. (2007) (124)
17 beta-estradiol 2- and 4-hydroxylation catalyzed by rat hepatic cytochrome P-450: roles of individual forms, inductive effects, developmental patterns, and alterations by gonadectomy and hormone replacement. (1986) (123)
Differential inhibition of individual human liver cytochromes P-450 by cimetidine. (1991) (123)
Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. (1985) (122)
Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. (1983) (122)
Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2 (2015) (122)
Intralobular distribution and quantitation of cytochrome P‐450 enzymes in human liver as a function of age (1991) (122)
Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity. (1993) (121)
Fidelity of Nucleotide Insertion at 8-Oxo-7,8-dihydroguanine by Mammalian DNA Polymerase δ (2001) (121)
The Role of Oxysterols in Human Cancer (2017) (121)
Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde. (1979) (120)
Characterization of cytochrome P-450 2B6 in human liver microsomes. (1993) (118)
Cytochrome P-450- and flavin-containing monooxygenase-catalyzed formation of the carcinogen N-hydroxy-2-aminofluorene and its covalent binding to nuclear DNA. (1982) (118)
Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver. (2000) (118)
Purified liver microsomal cytochrome P-450. Electron-accepting properties and oxidation-reduction potential. (1975) (117)
Cytochromes P-450. (1988) (117)
Efficient and High Fidelity Incorporation of dCTP Opposite 7,8-Dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA Polymerase Dpo4* (2005) (116)
Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N,N-Dialkylanilines by Cytochrome P450 2B1 (1996) (116)
Characterization of cimetidine, ranitidine, and related structures' interaction with cytochrome P-450. (1983) (115)
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. (1988) (115)
Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P-450. (1981) (115)
Aflatoxin B1 activation in human lung. (1997) (115)
Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. (1996) (115)
Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1 (2006) (114)
Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. (1992) (114)
Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. (1995) (114)
Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA. (1981) (113)
Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. (1997) (112)
Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters. (2010) (112)
Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters. (2010) (112)
Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 heme. (1985) (110)
Translesion Synthesis across O6-Alkylguanine DNA Adducts by Recombinant Human DNA Polymerases* (2006) (109)
Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs (2001) (109)
7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. (1996) (108)
Mechanism of cytochrome P-450 inhibition by cyclopropylamines (1982) (108)
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. (2000) (107)
New applications of bacterial systems to problems in toxicology. (1996) (107)
Substrate binding to cytochromes P450 (2008) (107)
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. (2010) (107)
Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450. (1976) (105)
Isolation and characterization of a l-pyrindine fungal alkaloid (1973) (105)
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. (1984) (104)
Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes. (1985) (104)
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate. (1996) (104)
Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization. (1995) (104)
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. (2004) (104)
Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. (1994) (103)
Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. (2001) (103)
Turnover of membrane proteins: kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase. (1984) (102)
Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. (1997) (102)
1,N 2-Ethenoguanine, a Mutagenic DNA Adduct, Is a Primary Substrate of Escherichia coliMismatch-specific Uracil-DNA Glycosylase and Human Alkylpurine-DNA-N-Glycosylase* (2002) (101)
Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. (1992) (101)
Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities (1995) (101)
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions. (2017) (100)
Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position. (1992) (100)
Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver. (1989) (100)
In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. (1996) (100)
Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. (1994) (100)
Mitochondria-targeted Cytochrome P450 2E1 Induces Oxidative Damage and Augments Alcohol-mediated Oxidative Stress* (2010) (99)
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. (1991) (99)
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype (2006) (98)
Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes. (1990) (98)
Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. (1999) (98)
Covalent binding of 1,2-dihaloalkanes to DNA and stability of the major DNA adduct, S-[2-(N7-guanyl)ethyl]glutathione. (1986) (98)
Immunohistochemical localizations of cytochromes P-450 in rat liver. (1978) (98)
Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. (2010) (97)
Aryl hydrocarbon receptor response to indigoids in vitro and in vivo. (2004) (97)
Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology (2011) (97)
Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe. (1995) (97)
Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. (1992) (96)
S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane. (1986) (96)
Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen. (1988) (96)
Metabolic activation of aromatic amines by human pancreas. (1997) (96)
“Phase I and Phase II” Drug Metabolism: Terminology that we Should Phase Out? (2005) (95)
Oxidation Kinetics of Ethanol by Human Cytochrome P450 2E1 (1997) (95)
Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs* (2015) (95)
Mammalian cytochromes P-450 (1987) (95)
Recombinant human cytochrome P450 1B1 expression in Escherichia coli. (1998) (94)
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. (1993) (93)
Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. (1995) (93)
Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. (2004) (93)
Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide (2008) (92)
Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications (2019) (92)
Interactions of carcinogen-bound DNA with individual DNA polymerases. (2006) (91)
[16] Production and application of antibodies to rat liver cytochrome P-450 (1981) (91)
Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5. (1997) (91)
Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver. (1991) (91)
Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450. (1989) (90)
Degradation Pathway of Bisphenol A: Does ipso Substitution Apply to Phenols Containing a Quaternary α-Carbon Structure in the para Position? (2007) (90)
Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4. (1992) (90)
Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. (2001) (90)
Kinetic Analysis of Oxidation of Coumarins by Human Cytochrome P450 2A6* (2005) (89)
Uncommon P450-catalyzed reactions. (2001) (89)
Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment. (1988) (89)
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. (1998) (88)
Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes. (1997) (88)
Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene. (1986) (87)
Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver. (1980) (87)
Maintenance of cytochrome P-450 in cultured adult human hepatocytes. (1985) (86)
Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. (2005) (86)
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). (1992) (85)
Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate (2011) (85)
Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids. (1990) (85)
Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms. (1979) (85)
Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes. (1982) (85)
The endo-8,9-epoxide of aflatoxin B1: a new metabolite. (1992) (84)
Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes. (2004) (83)
Immunohistochemical localization of cytochrome P-450 in rat brain (1987) (83)
KINETICS AND MECHANISM OF HYDROLYSIS OF AFLATOXIN B1 EXO-8,9-EPOXIDE AND REARRANGEMENT OF THE DIHYDRODIOL (1996) (83)
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. (2002) (82)
Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. (1985) (82)
Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. (1993) (82)
Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes. (1997) (81)
Cytochrome P450 3A4-catalyzed Testosterone 6β-Hydroxylation Stereochemistry, Kinetic Deuterium Isotope Effects, and Rate-limiting Steps* (2005) (81)
The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals. (1993) (80)
Oxidative metabolism of lansoprazole by human liver cytochromes P450. (1995) (80)
Sulfolobus solfataricus DNA Polymerase Dpo4 Is Partially Inhibited by “Wobble” Pairing between O6-Methylguanine and Cytosine, but Accurate Bypass Is Preferred* (2007) (80)
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation. (1988) (80)
Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. (2001) (79)
Analysis of Coumarin 7-Hydroxylation Activity of Cytochrome P450 2A6 using Random Mutagenesis* (2005) (79)
Studies on the structure-activity relationships for the metabolism of polybrominated biphenyls by rat liver microsomes. (1985) (79)
Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems* (2008) (79)
Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase. (2005) (78)
Specificity of 17β-oestradiol and benzo[α]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432 (2001) (78)
Localization of a cytochrome P-450 isozyme (cytochrome P-450 PB-B) and NADPH-cytochrome P-450 reductase in rat nasal mucosa. (1985) (77)
Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. (1987) (77)
Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. (1997) (77)
Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes. (1995) (77)
Xenobiotic-metabolizing Cytochromes P450 Convert Prostaglandin Endoperoxide to Hydroxyheptadecatrienoic Acid and the Mutagen, Malondialdehyde* (2000) (77)
Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme. (1982) (76)
Interaction of cimetidine with liver microsomes. (1979) (76)
Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation. (1995) (76)
Electron Transport Pathway for a Streptomyces Cytochrome P450 (2007) (76)
Evidence for an Episulfonium Ion Intermediate in the Formation of S-[2-(N7-Guanyl)ethyl]glutathione in DNA (1988) (76)
Kinetic Analysis of the Three-step Steroid Aromatase Reaction of Human Cytochrome P450 19A1* (2010) (76)
Forging the links between metabolism and carcinogenesis. (2001) (76)
Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants* (2012) (75)
Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. (2004) (75)
Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation. (1986) (75)
Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Human DNA Polymerase η*♦ (2014) (74)
Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. (1999) (74)
Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure. (1984) (74)
Preparation and properties of highly purified cytochrome p-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits. (1977) (74)
Hydrogen Bonding of 7,8-Dihydro-8-oxodeoxyguanosine with a Charged Residue in the Little Finger Domain Determines Miscoding Events in Sulfolobus solfataricus DNA Polymerase Dpo4*♦ (2007) (74)
Mechanism of cytochrome P-450 catalysis. Mechanism of N-dealkylation and amine oxide deoxygenation (1985) (74)
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. (2005) (73)
Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli. (1998) (73)
Purification of functional recombinant P450s from bacteria. (1996) (73)
Oxidative cleavage of carboxylic esters by cytochrome P-450. (1987) (73)
Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes. (1997) (73)
Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). (2003) (73)
Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. (2000) (73)
Partitioning between N-dealkylation and N-oxygenation in the oxidation of N,N-dialkylarylamines catalyzed by cytochrome P450 2B1. (1993) (73)
Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases. (1993) (73)
Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. (2013) (73)
Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. (1994) (73)
Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. (1994) (73)
Interaction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid. (1984) (72)
Roles of the vinyl chloride oxidation products 2-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases (1992) (72)
Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin. (1980) (72)
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. (2000) (72)
Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase (2014) (72)
Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs. (1998) (71)
Structural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase κ Opposite the 7,8-Dihydro-8-oxo-2′-deoxyguanosine Adduct* (2009) (71)
Functional characterization of four allelic variants of human cytochrome P450 1A2. (2004) (71)
Polymorphism of cytochrome P-450 in humans. (1989) (70)
Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. (2001) (70)
Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes. (1987) (70)
Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174. (1995) (70)
Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme. (1984) (70)
Kinetic Evidence for Inefficient and Error-prone Bypass across Bulky N2-Guanine DNA Adducts by Human DNA Polymerase ι* (2006) (69)
The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. (2002) (69)
Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization (1992) (69)
3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen. (1980) (69)
16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. (1998) (69)
Mechanism-based inactivation of cytochrome P-450 by heteroatom-substituted cyclopropanes and formation of ring-opened products (1984) (69)
Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes. (1986) (69)
Multiple Sequential Steps Involved in the Binding of Inhibitors to Cytochrome P450 3A4* (2007) (69)
Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes. (1985) (68)
Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes. (1995) (68)
Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide. (1982) (67)
Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. (1996) (67)
Expression of cytochrome P450 3A5 in Escherichia coli: effects of 5' modification, purification, spectral characterization, reconstitution conditions, and catalytic activities. (1995) (66)
Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-. (1996) (66)
Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver. (1987) (66)
Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. (1989) (66)
Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs. (1990) (66)
Metabolic activation and carcinogen-DNA adduct detection in human larynx. (1994) (66)
Reaction of aflatoxin B(1) oxidation products with lysine. (2002) (66)
Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chemically induced toxicity. (1988) (65)
Characterization of Orphan Human Cytochromes P450 (2007) (65)
Effects of nutritive factors on metabolic processes involving bioactivation and detoxication of chemicals. (1984) (65)
Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. (1989) (64)
Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. (1988) (64)
Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. (2012) (64)
Immunochemical comparison and quantitation of microsomal flavin-containing monooxygenases in various hog, mouse, rat, rabbit, dog, and human tissues. (1982) (64)
Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. (1999) (63)
Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis. (1997) (63)
Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. (2010) (63)
Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction* (2014) (63)
Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. (2004) (63)
Role of Active Site Water Molecules and Substrate Hydroxyl Groups in Oxygen Activation by Cytochrome P450 158A2 (2005) (63)
CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. (2013) (62)
Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors. (2007) (61)
Expansion of Substrate Specificity of Cytochrome P450 2A6 by Random and Site-directed Mutagenesis* (2005) (61)
Kinetic Analysis of Steps in the Repair of Damaged DNA by Human O6-Alkylguanine-DNA Alkyltransferase* (2005) (61)
In Vitro techniques for studying drug metabolism (1996) (61)
Drug metabolic enzymes in developmental toxicology. (1996) (61)
Versatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts* (2009) (61)
Membrane insertion of cytochrome P450 1A2 promoted by anionic phospholipids. (1998) (60)
Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. (2006) (60)
Characterization of roles of human cytochrome P-450 enzymes in carcinogen metabolism (1990) (60)
Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. (1996) (60)
Cooperativity in Oxidation Reactions Catalyzed by Cytochrome P450 1A2 (2008) (60)
Analysis and Characterization of Enzymes and Nucleic Acids (2007) (60)
Metabolism of 3-tert-butyl-4-hydroxyanisole by microsomal fractions and isolated rat hepatocytes. (1985) (59)
Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology. (2016) (59)
Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA. (1999) (59)
Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Mitochondrion-targeted Cytochrome P450 2D6 (2012) (59)
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2. (2001) (59)
Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta. (1997) (58)
Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. (2002) (58)
Update information on drug metabolism systems--2009, part I. (2010) (58)
Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. (1999) (58)
Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. (1996) (58)
Update information on drug metabolism systems--2009, part I. (2010) (58)
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases. (2001) (58)
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation. (2005) (58)
Roles of the Four DNA Polymerases of the Crenarchaeon Sulfolobus solfataricus and Accessory Proteins in DNA Replication* (2011) (58)
Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification. (1996) (57)
Comparison of rainbow trout and mammalian cytochrome P450 enzymes: evidence for structural similarity between trout P450 LMC5 and human P450IIIA4. (1991) (57)
Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. (1997) (57)
Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. (1984) (57)
Kinetic Analysis of Translesion Synthesis Opposite Bulky N2- and O6-Alkylguanine DNA Adducts by Human DNA Polymerase REV1* (2008) (57)
The Environmental Genome Project: functional analysis of polymorphisms. (1998) (57)
Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. (2012) (57)
Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. (2003) (57)
The induction of alkoxyresorufin metabolism: A potential indicator of environmental contamination (1990) (57)
Metabolism of vinyl chloride: destruction of the heme of highly purified liver Microsomal cytochrome P-450 by a metabolite. (1977) (56)
Cytochrome P450 Enzymes (2010) (56)
Decreased intestinal CYP3A in celiac disease: Reversal after successful gluten‐free diet: A potential source of interindividual variability in first‐pass drug metabolism (1996) (56)
Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine. (1998) (56)
Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations. (1995) (56)
Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. (2001) (55)
Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone (2008) (55)
Expression of mammalian cytochrome P450 enzymes using yeast-based vectors. (1991) (55)
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. (2000) (55)
Heterologous expression of human drug-metabolizing enzymes. (1997) (55)
Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products. (1996) (54)
Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method. (1999) (54)
Kinetic Analysis of Nucleotide Incorporation by Mammalian DNA Polymerase δ* (2000) (54)
Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. (1990) (54)
High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge. (1996) (54)
Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. (2001) (54)
Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. (1996) (53)
Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions. (2013) (53)
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. (2003) (53)
A malleable catalyst dominates the metabolism of drugs (2006) (53)
Similarities and differences in the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting in male rats. (1989) (53)
Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites. (1999) (52)
Oxidation-reduction properties of rat liver cytochromes P-450 and NADPH-cytochrome p-450 reductase related to catalysis in reconstituted systems. (1983) (52)
Circular dichroism and gel filtration study of binding of prochiral and chiral 1,4-benzodiazepin-2-ones to human serum albumin. (1979) (52)
In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids. (1981) (51)
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO (2014) (51)
Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4 (2007) (51)
Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. (2011) (51)
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. (2002) (51)
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase (2015) (51)
In Vivo Oxidative Damage in Rats Is Associated with Barbiturate Response but Not Other Cytochrome P450 Inducers (2007) (51)
Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: evidence for two binding sites. (2001) (50)
The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. (2001) (50)
Detection of free radicals produced from the reaction of cytochrome P-450 with linoleic acid hydroperoxide. (1997) (50)
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats. (1982) (50)
Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology. (1992) (50)
Reaction of cytochrome P450 with cumene hydroperoxide: ESR spin-trapping evidence for the homolytic scission of the peroxide O-O bond by ferric cytochrome P450 1A2. (1996) (49)
Identification of intratissue sites for xenobiotic activation and detoxication. (1986) (49)
Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. (1995) (49)
Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters. (1988) (49)
Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives. (1990) (48)
Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression (1999) (48)
Cytochrome P450 research and The Journal of Biological Chemistry (2019) (48)
Metabolism of 17 alpha-ethynylestradiol in humans. (1990) (48)
Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes. (1996) (48)
The relationships between cytochromes P450 and H2O2: Production, reaction, and inhibition. (2018) (48)
Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide. (1992) (48)
Oxidation of N-Nitrosoalkylamines by Human Cytochrome P450 2A6 (2010) (48)
Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. (2004) (48)
Immunological comparison of rat, rabbit, and human liver NADPH-cytochrome P-450 reductases. (1981) (47)
Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis* (2009) (47)
Analysis of the Effect of Bulk at N2-Alkylguanine DNA Adducts on Catalytic Efficiency and Fidelity of the Processive DNA Polymerases Bacteriophage T7 Exonuclease- and HIV-1 Reverse Transcriptase*[boxs] (2004) (47)
A history of the roles of cytochrome P450 enzymes in the toxicity of drugs (2020) (47)
Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase. (1997) (47)
A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system. (1996) (46)
Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. (2006) (46)
Roles of Cytochrome P450 in Metabolism of Ethanol and Carcinogens. (2018) (46)
Oxidation of Methoxyphenethylamines by Cytochrome P450 2D6 (2002) (46)
Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water. (1982) (46)
Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase ι* (2010) (46)
Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations. (2007) (46)
Testosterone 1β‐hydroxylation by human cytochrome P450 3A4 (2004) (46)
Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl. (1992) (46)
Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes. (1983) (45)
Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene. (1993) (45)
Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase* (2004) (45)
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalomethanes. (2001) (45)
Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome P4501A2 (2003) (45)
Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. (2009) (44)
Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. (2000) (44)
Cytochrome P450: advances and prospects (1992) (44)
Activation of dihaloalkanes by thiol-dependent mechanisms. (2003) (44)
Metabolism of acrylonitrile by isolated rat hepatocytes. (1983) (44)
Rate-Limiting Steps in Cytochrome P450 Catalysis (2002) (44)
Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes. (1999) (44)
Immunological comparison of rat, rabbit, and human microsomal cytochromes P-450. (1981) (44)
Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction. (2011) (44)
Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models* (2013) (44)
Studies on the activation of a model furan compound--toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan. (1977) (43)
Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes. (1990) (43)
Paradoxical Enhancement of the Toxicity of 1,2-Dibromoethane byO 6-Alkylguanine-DNA Alkyltransferase* (2002) (43)
Structural and Kinetic Basis of Steroid 17α,20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2* (2014) (43)
Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S] (2014) (43)
Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. (2013) (42)
Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. (1997) (42)
Purification and comparative properties of NADPH-cytochrome P-450 reductase from rat and rainbow trout: differences in temperature optima between reconstituted and microsomal trout enzymes. (1983) (42)
Oxidation of sparteines by cytochrome P-450: evidence against the formation of N-oxides. (1984) (42)
Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin. (1979) (42)
Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. (1990) (41)
Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver. (1989) (41)
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. (2002) (41)
Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures. (2007) (41)
Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm. (2010) (41)
Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts. (1987) (41)
Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. (1997) (41)
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. (2016) (41)
Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase η* (2015) (40)
Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. (1990) (40)
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. (2009) (40)
Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine. (1993) (40)
Cytochrome P450 2E1 and its roles in disease. (2020) (40)
Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery (2006) (40)
Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2. (1999) (40)
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. (2008) (40)
Biochemical Basis of Genotoxicity of Heterocyclic Arylamine Food Mutagens (2006) (39)
In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. (2012) (39)
Preparation and characterization of monoclonal antibodies to pregnenolone 16-α-carbonitrile inducible rat liver cytochrome P-450☆ (1986) (39)
The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype. (1987) (39)
Major isozymes of rat liver microsomal cytochrome P-450 involved in the N-oxidation of N-isopropyl-alpha-(2-methylazo)-p-toluamide, the azo derivative of procarbazine. (1984) (39)
Radical cation intermediates in N-dealkylation reactions. (1995) (39)
Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. (1993) (39)
Cytochrome P450 proteins and potential utilization in biodegradation. (1995) (38)
Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians. (2002) (38)
Conformational change and activation of cytochrome P450 2B1 induced by salt and phospholipid. (1998) (38)
Rat and human microsomal epoxide hydratase. Immunological characterization of various forms of the enzyme. (1979) (38)
Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys. (1993) (38)
7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. (2013) (38)
Human drug metabolism in vitro. (1988) (38)
Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations (2006) (38)
Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5 (2009) (38)
Metabolism of [14C]- and [36C]-labeled vinyl chloride in vivo and in vitro. (1979) (38)
Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues. (1998) (38)
Kinetic Analysis of Correct Nucleotide Insertion by a Y-family DNA Polymerase Reveals Conformational Changes Both Prior to and following Phosphodiester Bond Formation as Detected by Tryptophan Fluorescence* (2008) (37)
Drug interactions of H2-receptor antagonists involving cytochrome P450 (CYPs) enzymes: from the laboratory to the clinic. (1999) (37)
Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. (1999) (37)
Heterologous expression, purification, and properties of human cytochrome P450 27C1. (2006) (37)
General approach to chiroptical characterization of binding of prochiral and chiral 1,4-benzodiazepin-2-ones to human serum albumin. (1979) (37)
Mechanism of Aqueous Decomposition of Trichloroethylene Oxide (1999) (37)
Characterization of S-[2-(N1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane. (1990) (37)
Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. (2015) (37)
Participation of a rat liver cytochrome P-450 induced by pregnenolone 16 alpha-carbonitrile and other compounds in the 4-hydroxylation of mephenytoin. (1985) (37)
In situ localization and distribution of xenobiotic-activating enzymes and aryl hydrocarbon hydroxylase activity in lungs of untreated rats. (1990) (37)
Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. (2012) (36)
Introduction: Human metabolites in safety testing (MIST) issue. (2009) (36)
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. (2004) (36)
Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation. (1983) (36)
Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. (2012) (36)
Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. (2010) (36)
Diversity in Mechanisms of Substrate Oxidation by Cytochrome P450 2D6 (2001) (36)
In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. (2013) (36)
Oxidation of 1,2,4,5-Tetramethoxybenzene to a Cation Radical by Cytochrome P450 (2000) (36)
Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids[S] (2012) (36)
Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1 (2016) (36)
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2. (2001) (35)
Noncoordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B and P-450ISF/BNF-G. (1986) (35)
Biosynthesis of New Indigoid Inhibitors of Protein Kinases Using Recombinant Cytochrome P450 2A6 (2005) (35)
Analysis of 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts. (1997) (35)
Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. (2009) (35)
Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. (2006) (35)
Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. (1993) (35)
In vivo oxidative cleavage of a pyridine-carboxylic acid ester metabolite of nifedipine. (1989) (35)
mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1 (2008) (35)
Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes (2019) (35)
Cytochrome P-450 enzymes and drug metabolism (1987) (35)
Immunocytochemical evidence for the maintenance of cytochrome P-450 isozymes, NADPH cytochrome C reductase, and epoxide hydrolase in pure and mixed primary cultures of adult human hepatocytes. (1986) (35)
D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. (2009) (34)
Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). (1992) (34)
Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis. (2001) (34)
Chromatographic assays of drug oxidation by human cytochrome P450 3A4 (2009) (34)
Oxidation of nonionic detergents by cytochrome P450 enzymes. (1998) (34)
Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. (2008) (34)
Identification of retained N-formylmethionine in bacterial recombinant mammalian cytochrome P450 proteins with the N-terminal sequence MALLLAVFL...: roles of residues 3-5 in retention and membrane topology. (1996) (34)
Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η* (2016) (34)
Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. (2010) (33)
Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication. (1999) (33)
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. (2005) (33)
Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed. (1986) (33)
Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450). (1984) (33)
Approaches to deorphanization of human and microbial cytochrome P450 enzymes. (2011) (33)
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. (2015) (33)
Altered regulation of cytochrome P-450 enzymes in choline-deficient cirrhotic male rat liver: impaired regulation and activity of the male-specific androst-4-ene-3,17-dione 16 alpha-hydroxylase, cytochrome P-450UT-A, in hepatic cirrhosis. (1987) (33)
Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. (1999) (33)
Acylation of protein lysines by trichloroethylene oxide. (2000) (33)
Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes. (1996) (33)
Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene. (1983) (32)
Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes. (1987) (32)
Oxidation of Endogenous N-Arachidonoylserotonin by Human Cytochrome P450 2U1* (2014) (32)
Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design1 (2016) (32)
Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression (2009) (32)
In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds (2017) (32)
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. (2008) (32)
Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction. (2010) (32)
Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct. (2005) (32)
Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines. (2004) (32)
Exploiting the Versatility of Human Cytochrome P450 Enzymes: The Promise of Blue Roses From Biotechnology (2001) (32)
Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. (2013) (32)
Random mutagenesis by whole-plasmid PCR amplification. (1998) (32)
Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein. (1997) (32)
Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. (1996) (32)
Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats. (1989) (31)
Expression of drug-metabolizing enzymes. (1997) (31)
Immunohistochemical localization of carcinogen-metabolizing enzymes within the rat and hamster exocrine pancreas. (1984) (31)
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1 (2017) (31)
Kinetic deuterium isotope effects for 7‐alkoxycoumarin O‐dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes (2006) (30)
Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo (2015) (30)
Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. (2008) (30)
Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. (2010) (30)
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. (2008) (30)
Similarity of nuclear and microsomal cytochromes P-450 in the in vitro activation of aflatoxin B1. (1979) (30)
Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase (2011) (30)
Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. (2009) (30)
Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis. (2001) (30)
Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition – toxic effects and benefits (2018) (30)
Conformational Changes during Nucleotide Selection by Sulfolobus solfataricus DNA Polymerase Dpo4* (2009) (30)
Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition – toxic effects and benefits (2018) (30)
Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics (2000) (30)
Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450. (1987) (30)
Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry. (2008) (29)
Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. (2011) (29)
Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1. (2013) (29)
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update (2021) (29)
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update (2021) (29)
The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. (2017) (29)
Induction of cytochrome P450-dependent monooxygenases in hamster tissues by fasting. (1993) (29)
The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. (2009) (29)
Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane. (1991) (29)
Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions. (2017) (29)
Comparison of highly-purified microsomal cytochromes P-450 and NADPH-cytochrome P-450 reductases by peptide mapping. (1978) (28)
Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct†,‡ (2009) (28)
Replication of N2,3-ethenoguanine by DNA polymerases. (2012) (28)
Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. (2003) (28)
Induction of various cytochromes CYP2B, CYP2C and CYP3A by phenobarbitone in non-human primates. (1992) (28)
Cytochromes P450 catalyze oxidation of α,β-unsaturated aldehydes (2007) (28)
Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis. (2009) (28)
The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. (2018) (28)
Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine. (2006) (28)
2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine. (1989) (28)
Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. (2009) (28)
Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. (1998) (28)
Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. (2009) (27)
Oxidation of 9-alkylanthracenes by cytochrome P450 2B1, horseradish peroxidase, and iron tetraphenylporphine/iodosylbenzene systems: anaerobic and aerobic mechanisms. (1996) (27)
Human DNA polymerase η accommodates RNA for strand extension (2017) (27)
Human DNA polymerase η has reverse transcriptase activity in cellular environments (2019) (27)
Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia. (1999) (27)
Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism (2009) (27)
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2′-deoxyguanosine* (2015) (27)
Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases* (2012) (27)
Inhibition of Human Cytochrome P450 3A4 by Cholesterol* (2011) (27)
Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11 (2014) (27)
Active site topology of human cytochrome P450 2E1. (1996) (27)
Update Information on Human P450s (2002) (27)
Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. (2018) (27)
Inhibition of NADPH-cytochrome P450 reductase by cyclophosphamide and its metabolites. (1981) (27)
Interpretations of cytochrome P450 mechanisms from kinetic studies. (1995) (27)
Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. (2018) (27)
Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. (2011) (26)
Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins. (1995) (26)
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. (2001) (26)
Structure and Activity of Y-class DNA Polymerase DPO4 from Sulfolobus solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene* (2007) (26)
Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases* (2016) (26)
Understanding electron transport systems of Streptomyces cytochrome P450. (2006) (26)
Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. (2009) (26)
Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis (2016) (26)
20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice (2016) (26)
The Human CYP1A1 Gene Is Regulated in a Developmental and Tissue-specific Fashion in Transgenic Mice* (2004) (26)
Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity. (1993) (26)
Interaction of epoxide hydrolase with itself and other microsomal proteins. (1982) (26)
In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. (2011) (26)
Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity. (1980) (25)
Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes (2018) (25)
Thematic Minireview Series: Metals in Biology* (2009) (25)
Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia (2017) (25)
Enzymatic mono oxygenation of halogen atoms cytochrome p 450 catalyzed oxidation of iodo benzene by iodoso benzene (1980) (25)
Mechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1. 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. (2016) (25)
Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification. (2001) (25)
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. (2007) (25)
Induction and inhibition of cytochrome P-450-dependent monooxygenases in hamster tissues by ethanol. (1993) (25)
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. (2005) (25)
In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1† (2010) (25)
Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice. (2015) (25)
Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]. (1992) (25)
Oxidation of Dihydrotestosterone by Human Cytochromes P450 19A1 and 3A4* (2012) (25)
Identification and quantitation of a 2.0-kilobase messenger ribonucleic acid coding for 3-methylcholanthrene-induced cytochrome P-450 using cloned cytochrome P-450 complementary deoxyribonucleic acid. (1982) (24)
Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. (2008) (24)
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens. (1992) (24)
Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues. (1995) (24)
Production and application of antibodies to rat liver cytochrome P-450. (1981) (24)
Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis* (2015) (24)
Coumarin substrates for cytochrome P450 2D6 fluorescence assays. (2001) (24)
Conformational selection dominates binding of steroids to human cytochrome P450 17A1 (2019) (24)
Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions. (2001) (24)
Immunochemical characterization and toxicological significance of P-450HFLb purified from human fetal livers. (1992) (24)
Activation of carcinogens by human liver cytochromes P-450. (1990) (24)
Steady‐State Kinetic Analysis of DNA Polymerase Single‐Nucleotide Incorporation Products (2014) (24)
Oxidative, Reductive, and Hydrolytic Metabolism of Drugs (2007) (24)
Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. (1999) (24)
Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins. (1989) (24)
An immunohistochemical study on the localization and distribution of epoxide hydrolase within livers of untreated rats. (1981) (24)
Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. (2014) (23)
Kinetics of Nucleotide Incorporation Opposite DNA Bulky Guanine N2 Adducts by Processive Bacteriophage T7 DNA Polymerase (Exonuclease–) and HIV-1 Reverse Transcriptase* (2005) (23)
Interactions of FK506 (tacrolimus) with clinically important drugs. (1996) (23)
Safety Assessment of Stable Drug Metabolites (2006) (23)
Activation of alkyl halides by glutathione transferases. (2005) (23)
Mechanisms of Cytochrome P450 Reactions (2009) (23)
Functional genomics and proteomics applied to the study of nutritional metabolism. (2001) (23)
Heme–thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition (2017) (23)
Molecular advances for the cytochrome P-450 superfamily. (1991) (23)
Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. (2009) (23)
Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. (2014) (23)
Thematic Series: Metals in Biology* (2009) (23)
Artifacts in isoelectric focusing of the microsomal enzymes cytochrome P-450 and NADPH-cytochrome P-450 reductase. (1979) (22)
Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration * (2018) (22)
Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting. (2010) (22)
Rosuvastatin: an independent analysis of risks and benefits. (2006) (22)
New Trends in Cytochrome P450 Research at the Half-Century Mark* (2013) (22)
Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. (2000) (22)
Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements. (1994) (22)
The sulfoxidation of the hexachlorobutadiene metabolite N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine is catalyzed by human cytochrome P450 3A enzymes. (1995) (21)
Activation of the parasympathomimetic alkaloid slaframine by microsomal and photochemical oxidation. (1977) (21)
Liquid Chromatography‐Mass Spectrometry Analysis of DNA Polymerase Reaction Products (2011) (21)
Characterization of nucleoside and DNA adducts formed by S-(1-acetoxymethyl)glutathione and implications for dihalomethane-glutathione conjugates. (2001) (21)
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay. (2001) (21)
FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. (2019) (21)
Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione. (1998) (21)
SEQUENTIAL ELECTRON TRANSFER REACTIONS CATALYZED BY CYTOCHROME P-450 ENZYMES (1993) (21)
Human cytochrome P450 27C1 catalyzes 3,4‐desaturation of retinoids (2016) (21)
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. (2004) (21)
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. (2009) (21)
Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes. (2007) (21)
Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate. (2003) (20)
RELATIONSHIP BETWEEN GRAFT CYTOCHROME P‐450 3A CONTENT AND EARLY MORBIDITY AFTER LIVER TRANSPLANTATION1 (1993) (20)
Effect of the suicide substrate 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine on the metabolism of xenobiotics and on cytochrome P-450 apoproteins. (1986) (20)
WHAT MAKES P450s WORK? SEARCHES FOR ANSWERS WITH KNOWN AND NEW P450s* (2000) (20)
Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 (1994) (20)
Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. (2013) (20)
Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries. (2009) (20)
Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants (2011) (20)
Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH‐cytochrome P450 reductase and bacterial O‐acetyltransferase in SOS/umu assay (2000) (20)
Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1. (2016) (20)
LIVER MICROSOMAL MEMBRANES: RECONSTITUTION OF THE HYDROXYLATION SYSTEM CONTAINING CYTOCHROME P-450* (1976) (20)
Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde. (1994) (20)
Formation and reactions of N(7)-aminoguanosine and derivatives. (1999) (20)
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice (2017) (20)
Metabolism and genotoxicity of dihaloalkanes. (1994) (20)
Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. (2001) (19)
FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients. (2019) (19)
Formation of etheno adducts of adenosine and cytidine from 1-halooxiranes. Evidence for a mechanism involving initial reaction with the endocyclic nitrogen atoms (1992) (19)
Lysine catabolism in Rhizoctonia leguminicola and related fungi (1976) (19)
Structure of formamidopyrimidine adducts as determined by NMR using specifically 15N-labeled guanosine. (1991) (19)
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13 (2016) (19)
Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases* (2015) (19)
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia. (2015) (19)
Effects of phenobarbital, trans-stilbene oxide, and 3-methylcholanthrene on epoxide hydrolase within centrilobular, midzonal, and periportal regions of rat liver. (1983) (19)
Metabolic Reactions: Types of Reactions of Cytochrome P450 Enzymes (1993) (19)
Translesion Synthesis across 1,N6-(2-Hydroxy-3-hydroxymethylpropan-1,3-diyl)-2′-deoxyadenosine (1,N6-γ-HMHP-dA) Adducts by Human and Archebacterial DNA Polymerases* (2012) (19)
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. (2009) (18)
High-throughput fluorescence assay of cytochrome P450 3A4 (2009) (18)
Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. (2004) (18)
Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants (2014) (18)
In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds (2019) (18)
Carcinogenesis of urethane: simulation versus experiment. (2015) (18)
Pig and minipig cytochromes P450. (2002) (18)
Inhibition of Drug Metabolizing Enzymes: Molecular and Biochemical Aspects (1999) (18)
Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. (2002) (18)
Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. (2016) (18)
Distributions of monooxygenase components and epoxide hydratase within the livers of untreated male rats. (1980) (18)
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol (2017) (18)
The safety evaluation of food flavouring substances: the role of metabolic studies. (2018) (18)
Scavenging of hypochlorous acid by lipoic acid (1991) (18)
Addition of deoxyribose to guanine and modified DNA based by Lactobacillus helveticus trans-N-deoxyribosylase. (1996) (18)
Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage (2010) (18)
Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics. (1981) (18)
Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism. (1990) (18)
Thematic Minireview Series: Metals in Biology 2012 (2012) (18)
Detergents as probes of reconstituted rat liver cytochrome P-450 function. (1987) (18)
Roles of different cytochrome P450 enzymes in bioactivation of the potent hepatocarcinogen 3-methoxy-4-aminoazobenzene by rat and human liver microsomes. (1991) (17)
Quantification of two cytochrome P-450 isoenzymes by an enzyme-linked immunosorbent assay (ELISA). (1984) (17)
Frameshift Deletion by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W Is Selective for Purines and Involves Normal Conformational Change Followed by Slow Phosphodiester Bond Formation* (2009) (17)
Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. (2006) (17)
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes. (2001) (17)
16 α-Hydroxylation of estrone by human cytochrome P 4503 A 4 / 5 (1998) (17)
Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl (2016) (17)
Chemical carcinogenesis, mutagenesis, and teratogenesis. (1996) (17)
Multiple cytochromes P-450 are translated from multiple messenger ribonucleic acids. (1983) (17)
The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins. (1981) (17)
Oxidation and Glycolytic Cleavage of Etheno and Propano DNA Base Adducts† (2009) (17)
Mechanisms of formation of DNA adducts from ethylene dihalides, vinyl halides, and arylamines. (1994) (17)
Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase. (1978) (17)
Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens (1992) (17)
Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells* (2016) (17)
Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. (2012) (16)
The safety evaluation of food flavoring substances: the role of genotoxicity studies (2020) (16)
Synthesis and insertion, both in vivo and in vitro, of rat-liver cytochrome P-450 and epoxide hydratase into Xenopus laevis membranes. (1981) (16)
Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. (1995) (16)
Translesion DNA Synthesis by Human DNA Polymerase η on Templates Containing a Pyrimidopurinone Deoxyguanosine Adduct, 3-(2′-Deoxy-β-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one† (2008) (16)
A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human livers. (1991) (16)
Structure of the 1,N2-Ethenodeoxyguanosine Adduct Opposite Cytosine in Duplex DNA: Hoogsteen Base Pairing at pH 5.2† (2008) (16)
Cytotoxicity and bioactivation mechanism of benzyl 2-chloro-1,1,2-trifluoroethyl sulfide and benzyl 1,2,3,4,4-pentachlorobuta-1,3-dienyl sulfide. (1988) (16)
Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. (2007) (16)
Preparation and characterization of oligonucleotides containing S-[2-(N7-guanyl)ethyl]glutathione. (1991) (16)
Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. (2012) (16)
Stereoselectivein-vitro aromatic-ring oxygenations of chiral 1,4-benzodiazepin-2-ones (1977) (16)
Structural and Kinetic Basis of Steroid 17 , 20-Lyase Activity in Teleost Fish Cytochrome P 450 17 A 1 and Its Absence in Cytochrome P 450 17 A 2 * (2015) (16)
The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism (1994) (16)
A convenient assay for mephenytoin 4-hydroxylase activity of human liver microsomal cytochrome P-450. (1985) (16)
Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis (2014) (16)
Procarcinogens by Cytochromes P 450 1 a 1 and P 450 1 B 1 Allelic Variants and Other Human Cytochromes P 450 in Salmonella Typhimurium Nm 2009 (2001) (15)
Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data (2019) (15)
Localization of epoxide-metabolizing enzymes in rat testis. (1984) (15)
Life and Times in Biochemical Toxicology (2005) (15)
Safety evaluation of substituted thiophenes used as flavoring ingredients. (2017) (15)
Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. (2016) (15)
Purification of Cytochromes P450 : Products of Bacterial Recombinant Expression Systems. (2006) (15)
Inhibition of oral contraceptive steroid‐metabolizing enzymes by steroids and drugs (1991) (15)
Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. (2008) (15)
FEMA GRAS assessment of natural flavor complexes: Clove, Cinnamon leaf and West Indian bay leaf-derived flavoring ingredients. (2020) (15)
Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes (2017) (15)
Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6. (2007) (15)
Validation of human sterol 14α-demethylase (CYP51) druggability: structure-guided design, synthesis and evaluation of stoichiometric, functionally irreversible inhibitors. (2019) (15)
Methods in Nutrition Science (2001) (15)
Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. (2010) (15)
Cataloging the Repertoire of Nature's Blowtorch, P450. (2009) (15)
Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol (2007) (15)
Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450. (1980) (15)
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin. (2003) (15)
Hydrodynamic characterization of highly purified and functionally active liver microsomal cytochrome P-450. (1979) (14)
Differences in the functional interaction of two purified cytochrome P-450 isozymes with epoxide hydrolase. (1981) (14)
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters. (2020) (14)
Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. (2015) (14)
S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage* (2004) (14)
Toxic effects and a structure--property study of organic explosives, propellants, and related compounds. (1994) (14)
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone (2019) (14)
Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes. (2004) (14)
Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. (2006) (14)
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. (2013) (14)
ENZYMATIC MONOOXYGENATION OF HALOGEN ATOMS: CYTOCHROME P-450 CATALYZED OXIDATION OF IODOBENZENE BY IODOSOBENZENE (1981) (14)
Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters. (2020) (14)
Selective alteration of constitutive hepatic cytochrome P-450 enzymes in the rat during parenteral hyperalimentation. (1989) (14)
Preferential activation of 6-aminochrysene and 2-aminoanthracene to mutagenic moieties by different forms of cytochrome P450 in hepatic 9000 X g supernatants from the rat. (1989) (14)
Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. (2010) (14)
Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase. (2005) (14)
Metabolic activation, DNA adducts, and H‐ras mutations in human neoplastic and non‐neoplastic laryngeal tissue (1993) (14)
7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway (2017) (14)
A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli. (2011) (14)
Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. (1987) (13)
Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases. (2013) (13)
In vivo interaction of acrylonitrile and 2-cyanoethylene oxide with DNA in rats. (1986) (13)
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants (2018) (13)
Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation. (1984) (13)
Metabolic activation of model pyrroles by cytochrome P-450. (1980) (13)
Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51 (2018) (13)
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. (2018) (13)
The use of human liver banks in pharmacogenetic research. (1989) (13)
Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1. (1996) (13)
Effects of various inducers on the expression of cytochromes P-450 IIC8, 9, 10 and IIIA in cultured adult human hepatocytes. (1990) (13)
Testing urine for drugs (1992) (13)
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2′-deoxyguanosine by Human DNA Polymerase η* (2016) (13)
7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites (2018) (13)
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. (1991) (13)
Mass spectrometry of 1,4‐benzodiazepines (1975) (13)
Formation of etheno adducts and their effects on DNA polymerases. (1999) (13)
Immunohistochemical localization of epoxide hydratase in rat liver. (1980) (13)
Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone (2019) (12)
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. (1994) (12)
Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. (2014) (12)
Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA (2005) (12)
Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects (2021) (12)
Inhibition of CYP 1 A 2 and CYP 3 A 4 by Oltipraz Results in Reduction of Aflatoxin B 1 Metabolism in Human Hepatocytes in Primary Culture ' (2006) (12)
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. (2017) (12)
Mechanisms of Enhancement and Inhibition of Cytochrome-P450 Catalytic Activities (1994) (12)
Targeting of Splice Variants of Human Cytochrome P450 2C8 (CYP2C8) to Mitochondria and Their Role in Arachidonic Acid Metabolism and Respiratory Dysfunction* (2014) (12)
Characterization of the microsomal cytochrome P-450 species induced in rat liver by trans-stilbene oxide. (1982) (12)
FEMA GRAS assessment of natural flavor complexes: Lavender, Guaiac Coriander-derived and related flavoring ingredients. (2020) (12)
FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients. (2019) (12)
Biphasic response for hepatic microsomal enzyme induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. (1989) (12)
Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. (1991) (12)
Mutagenicity of a glutathione conjugate of butadiene diepoxide. (2010) (11)
Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. (2016) (11)
Characterization of a fusion protein between human cytochrome P450 1A1 and rat NADPH-P450 oxidoreductase in Escherichia coli. (1997) (11)
1,3-Butadiene: linking metabolism, dosimetry, and mutation induction. (1994) (11)
Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. (2006) (11)
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η* (2016) (11)
Characterization of a rat liver cytochrome P-450UT-H cDNA clone and comparison of mRNA levels with catalytic activity. (1987) (11)
STEREOSELECTIVE IN-VITRO AROMATIC-RING OXYGENATIONS OF CHIRAL 1,4-BENZODIAZEPIN-2-ONES (1977) (11)
Testing urine for drugs. (1992) (11)
Organic solvents as modifiers of aldrin epoxidase in reconstituted monooxygenase systems and in microsomes. (1989) (11)
Incorporation of Nucleoside Probes Opposite O6‐Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding (2013) (11)
Metabolism of A^-Nitrosodialkylamines by Human Liver Microsomes1 (1988) (11)
Structure of the 1,N2-Etheno-2′-deoxyguanosine Lesion in the 3′-G(εdG)T-5′ Sequence Opposite a One-Base Deletion† (2010) (10)
Evidence for a 1-Electron Oxidation Mechanism in N-Dealkylation of N , N-Dialkylanilines by Cytochrome P 450 2 B 1 KINETIC HYDROGEN ISOTOPE EFFECTS (1996) (10)
Unusual Metabolic Reactions and Pathways (2014) (10)
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. (2007) (10)
Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. (2019) (10)
Effects of human choriogonadotropin on mitochondrial and microsomal cytochrome P-450 levels in mouse testes. (1983) (10)
Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4. (2004) (10)
The characterization of N-isopropyl-p-hydroxymethylbenzamide formed during the oxidative metabolism of azo-procarbazine. (1982) (10)
Generation of reactive intermediates (2005) (10)
Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. (2013) (10)
Thematic Minireview Series: Metals in Biology 2010* (2010) (10)
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine. (2002) (10)
A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis (2020) (10)
A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach (2019) (10)
FEMA GRAS assessment of natural flavor complexes: Eucalyptus oil and other cyclic ether-containing flavoring ingredients. (2021) (9)
Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. (2015) (9)
Purification of Cytochromes P450 (1998) (9)
N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule. (1993) (9)
Species- and gender-related differences in amine, alcohol and phenol sulphoconjugations. (1995) (9)
Reactive intermediates in biological systems: what have we learned and where are we going? (2001) (9)
Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. (2004) (9)
GRAS 28 flavoring substances (2018) (9)
Enantioselective hydrolysis of oxazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction. (1990) (9)
The Dose—Response Model for Dioxin (1998) (9)
Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. I. Pipecolic acid and slaframine biogenesis. (1973) (9)
Modulation of the Structure, Catalytic Activity, and Fidelity of African Swine Fever Virus DNA Polymerase X by a Reversible Disulfide Switch* (2009) (9)
Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches. (2013) (9)
Immunotoxicology and expression of human cytochrome P450 in microorganisms. (1993) (9)
Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes (2018) (9)
FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results. (2016) (9)
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry. (2016) (9)
Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). (2010) (9)
In-Vitro Metabolism of FK506, Cytochrome P450 and Drug Interactions (1993) (9)
Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA. (2018) (8)
Biochemical characterization of highly purified cytochrome P-450 and other components of the mixed function oxidase system of liver microsomal membranes. (1975) (8)
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study. (1998) (8)
Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties. (1993) (8)
Mechanism of C 8 alkylation of guanine residues by activated arylamines : Evidence for initial adduct formation at the N 7 position ( aromatic amines / DNA adducts / chemical carciogens ) (8)
Protective Role of Glutathione Against Peroxynitrite-Mediated DNA Damage During Acute Inflammation. (2020) (8)
The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. (2010) (8)
Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements. (1994) (8)
FEMA GRAS assessment of natural flavor complexes: Origanum oil, thyme oil and related phenol derivative-containing flavoring ingredients. (2021) (8)
Immunohistochemical demonstration of β‐naphthoflavone–inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells (1998) (8)
Thematic Minireview Series: Metals in Biology 2013 (2013) (8)
Lesion orientation of O4-alkylthymidine influences replication by human DNA polymerase η (2016) (8)
Introduction: use of radioactive compounds in drug discovery and development. (2012) (8)
Synthesis of oligonucleotides containing the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione at a single site. (1997) (8)
Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. (1999) (8)
Formation of Etheno Adducts of Adenosine and Cytidine from 1- Halooxiranes. Evidence for a Mechanism Involving Initial Reaction with the Endocyclic Nitrogen Atoms. (1992) (8)
Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition. (2020) (8)
High-throughput fluorescence assay of cytochrome P450 3A4. (2013) (7)
Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. (2013) (7)
The abundant DNA adduct N7-methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η (2019) (7)
Purification and characterization of the major microsomal cytochrome P-450 form induced by trans-stilbene oxide in rat liver. (1984) (7)
Involvement of cytochrome P450 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa. (1994) (7)
Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters (2009) (7)
Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). (2012) (7)
Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair (2020) (7)
Structure-Function Relationships in Miscoding by Sulfolobus solfataricus DNA Polymerase Dpo4 (2009) (7)
Drug Metabolism as Catalyzed by Human Cytochrome P450 Systems (2007) (7)
Thematic Minireview Series: Metals in Biology 2014* (2014) (7)
Enzymatic transformations. (1981) (7)
1 In Vitro Cytochrome P 450 46 A 1 ( CYP 46 A 1 ) Activation by Neuroactive Compounds (2017) (7)
Metabolism of vinyl halides: in vitro studies on roles of potential activated metabolites. (1981) (7)
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. (2016) (7)
Dihaloalkanes and polyhaloalkenes. (1994) (7)
Tight binding of cytochrome b5 to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis (2021) (7)
Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models (2019) (7)
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes. (1990) (7)
Mechanisms of Mutagenicity of DNA Adducts Derived from Alkyl and Vinyl Halides (1997) (7)
Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsomes and rat brain S9 fraction. (1991) (7)
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι* (2016) (6)
Pre‐Steady‐State Kinetic Analysis of Single‐Nucleotide Incorporation by DNA Polymerases (2016) (6)
DIFFERENTIAL INDUCTION OF RAT HEPATIC CYTOCHROMES P 450 3 A 1 , 3 A 2 , 2 B 1 , 2 B 2 , AND 2 E 1 IN RESPONSE TO PYRIDINE TREATMENT (2001) (6)
Kinetic Evidence for an Induced Fit Mechanism in the Binding of the Substrate Camphor by Cytochrome P450cam. (2020) (6)
Interaction of stanozolol with cytochrome P-450. (1988) (6)
CHAPTER 4 – PURIFICATION AND CHARACTERIZATION OF LUNG ENZYMES INVOLVED IN XENOBIOTIC METABOLISM (1993) (6)
GRAS 29 flavoring substances (2020) (6)
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide. (2002) (6)
DETOXICATION OF AFLATOXIN B1 AS A MODEL FOR CARCINOGEN METABOLISM (1998) (6)
Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells (2019) (6)
Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts. (1997) (6)
Activation of mutagens by human cytochrome P-450 enzymes. (1990) (6)
N-HYDROXYARYLAMINES (2002) (6)
Cytochrome P450‐Mediated Drug Interaction and Cardiovascular Safety: The Seldane to Allegra Transformation (2014) (6)
Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes (2020) (6)
Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1. (2019) (6)
Expression of Human Cytochrome-P-450-3A4 and Cytochrome-P450-2E1 in the Bacterium Escherichia-Coli (1992) (6)
Oxidation and conjugation of aflatoxins by humans and experimental animals. (1992) (6)
Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process (2020) (6)
Where is Toxicology Headed in the Future? (2004) (6)
Reaction of the model thiol 2-mercaptoethanol and glutathione with methylvinylmaleimide, a Michael acceptor with extended conjugation. (1987) (6)
Structure and function of the translesion DNA polymerases and interactions with damaged DNA (2015) (6)
Evolution of the scientific literature of cytochrome P450 from 1977 to 2008. (2010) (6)
Structure and function of cytochrome P-450. (1986) (6)
Time- and NADPH-Dependent Inhibition of Cytochrome P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral Changes (2014) (6)
Enzymatic bypass of an N6-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases (2021) (5)
Human liver debrisoquine 4-hydroxylase: test for specifity toward various monooxygenase substrates and model of the active site (2004) (5)
Inhibition of Cytochrome P450 Enzymes by Drugs—Molecular Basis and Practical Applications (2021) (5)
Structure − Function Studies of Naphthalene , Phenanthrene , Biphenyl , and Their Derivatives in Interaction with and Oxidation by Cytochromes P 450 2 A 13 and 2 A 6 (2016) (5)
Symposium overview: Characterization of xenobiotic metabolizing enzyme function using heterologous expression systems. (1999) (5)
Aryl Hydrocarbon Receptor Activation and Cytochrome P 450 1 A Induction by the Mitogen-Activated Protein Kinase Inhibitor U 0126 in Hepatocytes (2004) (5)
Synthesis and Characterization of Site‐Specific O6‐Alkylguanine DNA‐Alkyl Transferase‐Oligonucleotide Crosslinks (2019) (5)
Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. (2002) (5)
Thematic Minireview Series on Biological Applications of Mass Spectrometry* (2011) (5)
Selective changes in cholesterol metabolite levels in plasma of breast cancer patients after tumor removal (2017) (5)
Some Changes in Submission and Handling Policies at the JBC (2015) (5)
Experimental Approaches to Analysis of Reactions of Cytochrome P450 Enzymes (2014) (5)
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions (2022) (5)
Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants. (2021) (5)
Cytochrome P 450 2 S 1 is Reduced by NADPH-Cytochrome P 450 Reductase (2011) (5)
Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes* (2016) (5)
The Vanderbilt University Center in Molecular Toxicology: the first 30 years. (1999) (5)
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. (2013) (5)
1 Unusual Cytochrome P 450 Enzymes and Reactions (5)
Multi-Step Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity. (2020) (5)
Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions (2019) (5)
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions (2022) (5)
Efficient and High Fidelity Incorporation of dCTP Opposite 7,8-Dihydro-8-oxodeoxyguanosine bySulfolobus solfataricus (2006) (5)
Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. (1986) (5)
Factors involved in the regulation of the levels and activities of rat liver cytochromes P-450. (1984) (5)
Stimulation of Cytochrome P450 Reactions by Apo-cytochromeb 5 (2001) (5)
Interactions of N7-guanyl methyl- and thioether-substituted d(CATGCCT) derivatives with d(AGGNATG). (1993) (5)
Effects of N-terminal modification of recombinant human cytochrome P450 1A2 on catalytic activity (2007) (4)
Roles of Cytochrome P450 1A1 and 1B1 in Metabolic Activation of Dibenzo[a, l]Pyrene by Microsomes from the Human Mammary Carcinoma Cell Line MCF-7 (2000) (4)
Target inactivation analysis applied to determination of molecular weights of rat liver proteins in the purified state and in microsomal membranes. (1987) (4)
Cytochrome P450 Activation of Toxins and Hepatotoxicity (2013) (4)
Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes (1996) (4)
Base Intercalation in DNA (2014) (4)
Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes. (1989) (4)
Oxidation Reactions Catalyzed by Cytochrome P-450 Enzymes (1990) (4)
Effects of acetone administration on cytochrome P-450-dependent monooxygenases in hamster liver, kidney, and lung (2005) (4)
Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation (2021) (4)
Mibefradil is a potent inhibitor of both CYP3A and P‐glycoprotein (P‐GP) (1999) (4)
IV. Identification of Cytochrome P450 3A Proteins as the Major Enzymes Responsible for the Oxidative Metabolism of Lovastatin in Rat and Human Liver Microsomes (1991) (4)
Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes. (2020) (4)
Applications of theoretical chemistry in the prediction of metabolism (1983) (4)
Cytochrome P450: advances and prospects. (1992) (4)
Chemical mechanisms of cytochrome P-450 catalysis (1990) (4)
Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145. (1997) (4)
Structural and chemical characterization of S-(2-(N/sup 7/-guanyl)-ethyl)glutathione, the major DNA adduct formed from 1,2-dibromoethane (1986) (4)
Kinetic Analysis of Translesion Synthesis Opposite Bulky N 2 - and O 6 -Alkylguanine DNA Adducts by Human DNA (2008) (4)
enzyme activities in human liver Systematic genetic and genomic analysis of cytochrome P 450 Material (2010) (4)
Highly purified cytochrome P-450 from liver microsomal membranes: recent studies on the mechanism of catalysis. (1976) (4)
EFFECTS OF XENOBIOTICS ON THE DISTRIBUTIONS OF MONOOXYGENASE COMPONENTS IN LIVER (1980) (4)
SYMPOSIUM OVERVIEW Drug Metabolic Enzymes in Developmental Toxicology1 (1996) (4)
Stereoselective metabolism of prazepam and halazepam by human liver microsomes. (1991) (4)
Propane and propylene formation during the microsomal metabolism of iproniazid and isopropylhydrazine. (1985) (4)
Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation (2020) (4)
Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. (2012) (4)
FEMA GRAS assessment of natural flavor complexes: Asafetida oil, garlic oil and onion oil. (2023) (3)
Cytochrome P450 7A1 Cholesterol 7α-Hydroxylation (2010) (3)
Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. (2015) (3)
Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases. (2017) (3)
Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases (2011) (3)
Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. II. The origin of pipecolic acid. (1973) (3)
Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes (2020) (3)
A POTENT INHIBITOR OF BOTH P-GLYCOPROTEIN AND CYP 3 A IN VITRO (2000) (3)
15th International Symposium on microsomes and drug oxidations (2005) (3)
Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future. (2022) (3)
Nucleophilic Thiol Proteins Bind Covalently to Abasic Sites in DNA. (2022) (3)
Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. (2021) (3)
Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene. (2017) (3)
Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene. (2017) (3)
Preparation, purification, and spectrophotometric characterization of cytochrome P450 1A2 conjugated with polyethylene glycol monomethyl ether. (1996) (3)
Purification of cytochromes P450: products of bacterial recombinant expression systems. (2006) (3)
Rat and human liver microsomal epoxide hydratase. Purification and evidence for multiple forms (1980) (3)
Toxicology Strategies for Drug Discovery - Present and Future: Introduction. (2016) (3)
Binding of (+)- and (-)-isomers and racemate of etomoxir to human serum albumin and effect of stearic acid and stanozolol. (1994) (3)
Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes? (2014) (3)
Stereochemical characterization of interactions of chiral 1,4-benzodiazepine-2-ones with liver microsomes (2010) (3)
A comparative study of some topological indices and log P in structure-property-activity analysis of phenylalkylamines (1993) (3)
What Happens When You Submit a Paper to JBC? (2017) (3)
Oxidation of Salicylic Acid and Aspirin by Human Cytochromes P450 (2015) (2)
The Natural Products Withaferin A and Withanone from the Medicinal Herb Withania somnifera Are Covalent Inhibitors of the SARS-CoV-2 Main Protease (2022) (2)
Chapter 2 Fifty Years of Progress in Drug Metabolism and Toxicology : What Do We Still Need to Know About Cytochrome P 450 Enzymes ? (2018) (2)
Strategies for more effective and reliable ADME (2004) (2)
Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H2O2 Sensitivity in POLI-Deficient Cells. (2020) (2)
DNA Cross-linking (2014) (2)
Purification of cytochromes P450. Rat and human hepatic forms. (1998) (2)
Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis (2021) (2)
A and morphine synthesis 1 Cytochrome P 450 3 A Enzymes Catalyze the O 6-Demethylation of Thebaine , a Key Step in Endogenous Mammalian Morphine Biosynthesis (2015) (2)
Inhibition of 7-Alkoxyresorufin O-Dealkylation Activities of Recombinant Human CYP1A1 and CYP1B1 by Resveratrol (2002) (2)
Human cytochrome P450 (CYP) enzymes in doping control: metabolism, interactions, adverse effects (1996) (2)
Introduction to Metals in Biology 2017: Iron transport, storage, and the ramifications (2017) (2)
Celebrating the scientific legacy of Herbert Tabor (2019) (2)
Inhibition of Drug Metabolizing Enzymes (2019) (2)
STEREOSELECTIVITY IN ENZYMATIC BIOTRANSFORMATION OF CHIRAL AND ACHIRAL 1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONES (1974) (2)
Comment on M.V. Evans and J.C. Caldwell: evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280-290, 2010. (2010) (2)
IMMUNOLOGICAL CROSS-REACTIVITY OF RAT LIVER AND HUMAN CYTOCHROMES P-450 (1980) (2)
Biochemistry of drug metabolism studies: metabolism of testosterone and T/E ratio (1994) (2)
Happy centennial birthday to Herb Tabor, pillar of JBC (2018) (2)
Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA 1535 leads to base-pair mutations upon exposure to dihalomethanes ( glutathione / chemical carcinogens / mutagenidty ) (2005) (2)
Mechanisms of formation of 1,N6-ethenoadenine, 3,N4-ethenocytosine, 1,N2-ethenoguanine and N2,3-ethenoguanine DNA adducts from substituted oxiranes. (1994) (2)
2. Cytochromes P450 (2012) (2)
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η (2021) (2)
Bypass DNA Polymerases (2011) (2)
O I.4 Roles of human cytochrome P450s 1A1, 1A2, 1B1, 2E1, and 3A4/5/7 in the activation of environmental procarcinogens and promutagens (1997) (2)
Evidence for formation of an S 12-( N 7-guanyl ) ethyllglutathione adduct in glutathione-mediated binding of the carcinogen 1 , 2-dibromoethane to DNA ( bioactivation / DNA adducts / glutathione S-transferase / N 7-ethylguanine ) (2)
Development of a mass spectrometric assay for 5,6,7,9-tetrahydro-7-hydroxy-9-oximidazo[1,2-alpha] purine in DNA modified by 2-chloro-oxirane. (1996) (2)
Retention of N-Formylmethionine in Recombinant Bacterial Cytochrome-P450 Enzymes Containing the N-Terminal Sequence Malllavfl (1995) (2)
FEMA GRAS assessment of natural flavor complexes: Allspice, anise, fennel-derived and related flavoring ingredients. (2023) (2)
Introduction: Metals in Biology (2015) (1)
Expression and Purification of Human Cytochrome-P450 Enzymes From Escherichia-Coli (1994) (1)
Study of the sporulation of Bacillus thuringiensis var. thuringiensis. (1975) (1)
Next-generation sequencing reveals the biological significance of the N[superscript 2],3-ethenoguanine lesion in vivo (2015) (1)
COVALENT BINDING OF VINYL CHLORIDE METABOLITES IN VITRO; ROLES OF CYTOCHROME P-450, NADPH-CYTOCHROME P-450 REDUCTASE, EPOXIDE HYDRATASE, AND ALCOHOL DEHYDROGENASE (1980) (1)
N-Nitroso-N-methylvinylamine: Reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule. [Erratum to document cited in CA118:118722] (1994) (1)
Structure and Activity of Y-class DNA Polymerase DPO4 from Sulfolobus solfataricus with Templates Containing the (2007) (1)
Drug Metabolism: A Half-Century Plus of Progress, Continued Needs, and New Opportunities (2022) (1)
Comparison of rates of enzymic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses [Erratum to document cited in CA110(23):207559z] (1989) (1)
[Prevention by metyrapone of halothane induced liver necrosis in rats (author's transl)]. (1982) (1)
Cell-catalyzed binding of 3H-(-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to cellular and exogenous DNA and the role of purified human liver epoxide hydrolase. (1988) (1)
Comparison of reconstitution conditions for recombinant human P450 2C9 with systems containing P450S 1A1, 1A2, 2D6, 2E1, and 3A4. Effects of P450-P450 and P450-b(5) interactions (1997) (1)
Sulfolobus solfataricus DNA Polymerase Dpo4 Is Partially Inhibitedby "Wobble"PairingbetweenO 6 -Methylguanine (2007) (1)
Metabolism and covalent binding of vic-dihaloalkanes, vinyl halides and acrylonitrile. (1986) (1)
1,N2-Etheno-2′-deoxyguanosine Adopts the syn Conformation about the Glycosyl Bond When Mismatched with Deoxyadenosine (2011) (1)
Human Cytochromes P450: Regulation and Functional Variability (1995) (1)
Symposium 13: Drugs of abuse: Metabolism, analysis and clinical implications (1990) (1)
Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylamines, and N,N -dimethylanilines by cytochrome P -450 enzymes (1991) (1)
Letter to the Editor Pig and Minipig Cytochromes P450 (1)
Molecular characterization of a renal cytochrome p450 epoxygenase responsive to animal sodium chloride loading (1992) (1)
Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids (2020) (1)
FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes. (2023) (1)
DNA polymerases η and κ bypass N2-guanine-O6-alkylguanine DNA alkyltransferase cross-linked DNA-peptides (2021) (1)
Working toward reducing bias in peer review (2021) (1)
Evidence for a Role of a Perferryl-Oxygen Complex, FeO 3 (cid:49) , in the N -Oxygenation of Amines by Cytochrome P450 Enzymes (1997) (1)
Introduction to Thematic Series: Protein Interactions, Structures, and Networks* (2015) (1)
Oxidative DNA Damage (2014) (1)
Competing Reactions of Aflatoxin B1Dialdehyde: Enzymatic Reduction versus Adduction with Lysine (2003) (1)
Working toward reducing bias in peer review (2021) (1)
STEREOSELECTIVE IN VITRO AROMATIC OXYGENATION OF CHIRAL 1,4-BENZODIAZEPIN-2-ONES (1977) (1)
Liquid chromatographic determination of para-substituted N,N-dialkylaniline N-oxides. (1993) (1)
Mechanisms of Enzyme Catalysis and Inhibition (2010) (1)
Biotransformation: Introduction and Historical Perspective (2010) (1)
Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides (2021) (1)
DNA-glutathione adducts derived from vic-dihaloalkanes: mechanisms of mutagenesis. (1990) (1)
Expression of Human Cytochrome-P450 Enzymes in Escherichia-Coli, Purification, and Reconstitution of Catalytic Activity (1993) (1)
WARFARIN METABOLISM - A PROBE OF PURIFIED RAT LIVER CYTOCHROMES P-450 (1980) (1)
Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition. (2021) (1)
Drug Metabolism: Cytochrome P450 (2021) (1)
10.03 – Mechanisms of Enzyme Catalysis and Inhibition☆ (2018) (1)
Purification of cytochromes P450: products of bacterial recombinant expression systems. (1998) (1)
Effect of N 2 -alkylguanine adducts on replication by Y-class Sulfolobus solfataricus DNA polymerase Dpo4 (2011) (1)
ormation of Indigo by Recombinant Mammalian ytochrome P 4501 (1999) (1)
Oxidation of Estrogens and Other Steroids by Cytochrome P-450 Enzymes: Relevance to Tumorigenesis (1992) (1)
Roles of Human CYP 2 A 6 and Monkey CYP 2 A 24 and 2 A 26 Cytochrome P 450 Enzymes in the Oxidation of 2 , 5 , 2 ́ , 5 ́Tetrachlorobiphenyl ́Tetrachlorobiphenyl ́Tetrachlorobiphenyl (2016) (1)
Introduction: Drug Metabolism and Toxicology Special Issue. (2020) (1)
Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes (2021) (1)
Distinguished service award, F. Peter Guengerich. (2005) (1)
METABOLISM OF FLUROXENE AND ANALOGOUS FLUORINATED ETHER ANESTHETICS BY HIGHLY PURIFIED CYTOCHROMES P-450 AND THE ASSOCIATED ENZYME DESTRUCTION (1980) (1)
Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons (1988) (1)
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes (2021) (1)
Mechanisms of Cytochrome P450‐Mediated Reactions (2012) (1)
Correction: Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. (2019) (1)
IDENTIFICATION OF RAT AND HUMAN CYTOCHROME P 450 FORMS INVOLVED IN THE METABOLISM OF THE THROMBOXANE A 2 RECEPTOR ANTAGONIST (1997) (1)
The Prevention of Halothane-Induced Liver Cell Necrosis in Rats with Metyrapone (1983) (1)
Ultraviolet Light DNA Damage (2014) (0)
AUTOCATALYZED COVALENT BINDING OF 3H(-)t-7,8-DIOL BENZO(a)PYRENE TO MIXED-FUNCTION OXIDASE ENZYMES AND DNA: THE ROLE OF EPOXIDE HYDRATASE (1980) (0)
OMEPRAZOLE HYDROXYLATION BY CYP2C19 AND CYP3A4: PREDICTION TOWARDS HUMAN LIVER ACTIVITIES USING THE DATA OF RECOMBINANT P450 ENZYMES (1997) (0)
DNA Damage by Endogenous Chemicals (2014) (0)
DNA Base Pairing, Modes of (2018) (0)
Spectroscopy of Damaged DNA (2014) (0)
Ternary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA with incoming dGTP (2009) (0)
Oxidation of 3’-methoxyflavone, 4’-methoxyflavone, and 3’,4’-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13 (2022) (0)
Practical Screening for DNA Damage (2014) (0)
CYP2A6*15およびCYP2A6*16の機能解析 (2004) (0)
Cytochrome P-450-and Flavin-containing Monooxygenase-catalyzed Formation of the Carcinogen A /-Hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DMA 1 (2006) (0)
Enzymes within the Rat and Hamster Exocrine Pancreas Immunohistochemical Localization of Carcinogen-metabolizing Updated (2006) (0)
Metabolism of Acrylonitrile by Isolated Rat Hepatocytes 1 (2006) (0)
2,4,3,5-Tetramethoxystilbene, a selective and potent inhibitor of human cytochrome P450 1B1 (2002) (0)
DNA Damage, Practical Screening for (2018) (0)
Relevance of DNA Damage to Cancer (2014) (0)
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases. (2023) (0)
DNA Damage, Relevance to Cancer (2018) (0)
S01-1Mechanisms of adverse drug reactions: Metabolic and others (2016) (0)
Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase. Vol. 279 (2004) 19217-19229 (2004) (0)
10.01 – Biotransformation: Introduction and Historical Perspective (2018) (0)
Functional basis of P 450 21 A 2 deficiencies 1 Functional Analysis of Human Cytochrome P 450 21 A 2 Variants Involved in Congenital Adrenal Hyperplasia (2017) (0)
DNA Damage, Types of (2018) (0)
Molecular Cloning and Expression of Fusion Proteins Containing Human Cytochrome P450 3As and Rat NADPH-P450 Reductase in Escherichia coli (2002) (0)
n of O 4-alkylthymidine in fl uences replication by human DNA polymerase h † (2016) (0)
OBSOLETE: Drug Metabolism: Cytochrome P450 (2020) (0)
and .16 in oxidation of midazolam, nifedipine, and testosterone (2008) (0)
1,N6‐Ethenoadenosine, a Damaged Ribonucleotide in DNA: Impact on Translesion Synthesis and Repair (2021) (0)
Response letter from ACSH phthalate panel. (2000) (0)
Cytochrome P450IIIA-mediated hydroxylation of dapsone in normal subjects and cirrhotics (1990) (0)
Chapter 23. Unique Roles of Human Translesion Synthesis DNA Polymerase η (2020) (0)
HYDRODYNAMIC CHARACTERIZATION OF LIVER MICROSOMAL CYTOCHROME P-450 (1980) (0)
DNA Damage, Frequency of (2018) (0)
Mitochondria Targeted Cytochrome P450 2E1: Potential Role in Alcohol Mediated Mitochondrial Oxidative Stress (2010) (0)
Identification of highly polymorphic S-mephenytoin hydroxyiase in humans (1995) (0)
Teranry complex of human DNA polymerase iota(26-445) inserting dCMPNPP opposite template G in the presence of Mg2+ (2016) (0)
Evidence for an Episulfonium Ion Intermediate in the Formation of S-(2-(N7-Guanyl)ethyl)glutathione in DNA. (1988) (0)
Corrigendum: Incorporation of Nucleoside Probes Opposite O6‐Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding (0)
AROMATIC AMINES AND NITROAROMATIC HYDROCARBONS (1988) (0)
Site-Specific Mutagenesis (2014) (0)
Kinetics of DNA Damage (2014) (0)
Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells (2023) (0)
Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. (2011) (0)
Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins. (1986) (0)
Rat and Human Microsomal Epoxide Hydratase (2002) (0)
MECHANISM OF N -OXIDATION REACTION CATALYZED BY CYTOCHROME P-450 (1994) (0)
Expression of P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of the recombinant enzyme (1997) (0)
Characterization of pirenzepine interaction with cytochrome P-450. (1985) (0)
Y-family DNA polymerase Dpo4 bypassing N2-naphthyl-guanine adduct in anti orientation (2008) (0)
Examining tissue-specific bioactivation in vitro: Cytochrome P450 1B1 and other extrahepatic forms in the metabolism of carcinogens (2000) (0)
A Novel Non‐oxidative [2+2] Cycloaddition of an Endogenous Substrate Catalyzed by Streptomyces coelicolor Cytochrome P450 154A1 (2011) (0)
Cytochrome P450 1 family: the roles of 1A1, 1A2 and 1B1 in drug metabolism (2016) (0)
DNA Polymerases , 3-Ethenoguanine by Human Y-family 2 N Basis of Miscoding of the DNA Adduct DNA and Chromosomes : (2012) (0)
Development of umu-test system Bioactivation of aromatic amines by human P450 1A2, NADPH-P450 reductase and/or O-acetyltransferase-expressing Salmonella typhimurium strains (1999) (0)
Cytochrome P450 Catalysis in the Biosynthesis of Natural Products (2019) (0)
Damaged DNA, Analysis of (2018) (0)
Effects of adduct formation derived from ethylene dibromide on DNA conformation. (1991) (0)
Direct Enzymatic Reversal of DNA Damage (2014) (0)
Damage DNA, Natural Products that (2018) (0)
Judy L. Bolton, 1962-2019. (2019) (0)
Ternary complex of human DNA polymerase eta inserting rATP opposite an 8-Oxodeoxyguanosine Lesion (2016) (0)
Reactive Oxygen Species (2014) (0)
Analysis of Damaged DNA (2014) (0)
Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. VOLUME 281 (2006) PAGES 2358-2372 (2008) (0)
O I.1 Chemistry of DNA-carcinogen adducts: Formation and biological effects (1997) (0)
S-1452及びそのβ-酸化代謝物の水酸化反応に関与するラット及びヒト肝チトクロームP-450分子種の比較 (1995) (0)
Electrophiles, Types of (2018) (0)
Interactions of Carcinogen‐Bound DNA with Individual DNA Polymerases (2006) (0)
NITROSAMINE METABOLISM IN HUMAN LIVER MICROSOMES organ donors who met accidental deaths and donated other tissues for transplant (2006) (0)
Interaction of Human Cytochrome P450 3A4 with Hydrophobicity Probe Nile Red Shows Heterogeneous, Strong Binding (2009) (0)
Types of DNA Damage (2014) (0)
Involvement of human P450s in the metabolic activation of heterocyclic amines using UMU tester strains (2000) (0)
CONTENTS (2006) (0)
Metabolic Activation of Procarcinogens by Human Cytochrome P450 Enzymes in Microsomes of Adult and Fetal Livers and of Adult Lungs (1995) (0)
Metabolism of cholesterol with Escherichia coli whole cells coexpressing P450 27A1 with adrenodoxin and adrenodoxin reductase (2011) (0)
Time- and NADPH-Dependent Inhibition of P450 3A4 by the Cyclopentapeptide Cilengitide: Significance of the Guanidine Group and Accompanying Spectral Changes (2014) (0)
Mechanism‐based Inhibition of Human Cytochrome P450 2D6 by SCH 66712 Involves Protein Adduction (2011) (0)
Ternary complex of Sulfolobus solfataricus Dpo4 DNA polymerase, O6- methylguanine modified DNA, and dATP. (2006) (0)
Evidence for cytochrome P45 ONF , the nifedipine oxidase , being the principal enzyme involved in the bioactivation of aflatoxins in human liver ( mutagenicity / drug metabolism / chemical carcinogens ) (0)
Fifty years after the discovery of cytochrome P450: what do we really know about the positive and negative roles in toxicology & health issues? (2012) (0)
Highly Purified Liver Microsomal Cytochrome P 450 : Properties and Catalytic Mechanism * (2018) (0)
DISCOVERIES IN BASIC ENZYMOLOGY AND APPLICATIONS TO PROBLEMS IN DRUG METABOLISM AND TOXICOLOGY (1997) (0)
Dr. Fred F. Kadlubar (1946–2010) (2011) (0)
Induction of human cytochrome P450 3A enzymes in hepatic and placental cells by thalidomide and relevance to bioactivation (2018) (0)
Using Fluorescence Spectroscopy to Evaluate Hill Parameters and Heterogeneity of Ligand Binding to Cytochromes P450 (2009) (0)
Time-dependent inhibition of CYP3A4-mediated midazolam metabolism by macrolide antibiotics in CYP3A4 genetic variants: Comparison with testosterone metabolism (2021) (0)
Analysis of cytochrome P450 2D6 : substrate interactions by site-directed mutagenesis (1998) (0)
DNA-Binding of a Carcinogen, 1, 2-Dibromoethane : Mechanism of Activation of the DNA-Binding by GSH and GSH S-Transferase (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology) (1984) (0)
ELUCIDATING THE FUNCTION OF ORPHAN HUMAN CYTOCHROME P450S (2010) (0)
Resource : Correlating Human Cytochrome P 450 21 A 2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia (2015) (0)
Mechanisms of Oxidations of Drugs and Carcinogens Catalyzed by Human P450s (2002) (0)
Cyp 27 c 1 RedShifts the S pectral Sensitivity of Photoreceptors by Converting Vitamin A 1 into A 2 Graphical Abstract Highlights (2015) (0)
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G (2015) (0)
Enyzmes | Structure and Function of Cytochrome P450 Enzymes (2020) (0)
Post-insertion complex of the Y-family DNA polymerase Dpo4 with M1dG containing template DNA (2009) (0)
Hill Parameters and Heterogeneity of alpha-Naphthoflavone Binding to Human Cytochrome P450 3A4 by Fluorescence Spectroscopic Analysis (2009) (0)
Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides (2021) (0)
RELATIONSHIPS BETWEEN GENETIC POLYMORPHISMS IN CYP2D6 AND CYP2E1 GENES AND LIVER MICROSOMAL DRUG OXIDATION ACTIVITIES (2000) (0)
Structure and function of the translesion DNA polymerases and interactions with (2015) (0)
3-Alpha-Hydroxylation and 8,9-Epoxidation of Aflatoxin-B(1) by Cytochrome-P450-3A4 - Evidence for Allosteric Behavior in Microsomal-Membranes and a Recombinant Enzyme (1993) (0)
Bioactivation of Carcinogens (2014) (0)
Cytochrome P-450- and Flavin-containing Monooxygenase-catalyzed Formation of the Carcinogen A/-Hydroxy-2-aminofluorene and Its Covalent Binding to Nuclear DMA1 (2006) (0)
Selectivity of Chemicals for DNA Damage (2014) (0)
Types of Electrophiles (2015) (0)
O-17 Detection of genomatic aromatic amines using umu-tester strains endogenously expressing human cytochrome P450 1A2 and a human NADPH-450 reductase, and/or bacterial O-acetyltransferase (1999) (0)
Correction to Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1. (2021) (0)
Anti-human liver cytochrome P-450 IA2 antibodies in patients with dihydralazine hepatitis (1990) (0)
Ternary complex of human DNA polymerase eta inserting rCTP opposite template G (2016) (0)
Modes of DNA Base Pairing (2014) (0)
Expression of human cytochrome P4501B1 in bacteria (1998) (0)
Obituary for Professor Allan H. Conney (1930–2013) (2013) (0)
Identification of the highly polymorphic S-mephenytoin hydroxylase in humans. (1996) (0)
Effects of Adducts on Tm (2014) (0)
Mass Spectrometry of Nucleic Acids (2015) (0)
Natural Products that Damage DNA (2014) (0)
Adducts on Tm, Effects of (2018) (0)
proteasome inhibitor carfilzomib in human cells (2016) (0)
Non-productive complex of the Y-family DNA polymerase Dpo4 with dGTP skipping the M1dG adduct to pair with the next template cytosine (2009) (0)
ANTIMICROSOMAL ANTIBODIES: WHAT ARE THEY (1991) (0)
Synthesis of Modified Oligonucleotides (2014) (0)
A sensitive umu test system for detecting genotoxicity of mutagenic dihaloalkanes using Salmonella typhimurium tester strain expressing rat glutathione S-transferase (1996) (0)
Cytochrome P450 3A enzyme-dependent thalidomide toxicity and inducibility in cultured human placental cells (2019) (0)
Structure and activity of human DNA polymerase kappa bypass of 8‐oxoG (2009) (0)
Dissecting changes in Dpo4 DNA polymerase structure during catalysis by hydrogen‐deuterium exchange mass spectrometry (2008) (0)
Sequence Selectivity of DNA Damage (2014) (0)
Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase STRUCTURE OF THE ENZYME (cid:2) PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C–H BOND CLEAVAGE * (2020) (0)
The molecular basis of the rhodopsin-porphyropsin switch (2015) (0)
Use of recombinant human P450 enzymes in the studies of drug metabolism and chemical carcinogenesis (2000) (0)
DNA Damage as a Therapeutic Strategy (2014) (0)
Catalytic mechanisms of amine-N-dealkylation and N-oxygenation by cytochrome P450 enzymes (1992) (0)
Biological chemistry without borders (2018) (0)
Selectivity of recombinant human cytochrome P450 enzymes in oxidation of benzo pyrene and aflatoxin B-1 (1995) (0)
Binary complex of Dpo4 bound to N2,N2-dimethyl-deoxyguanosine modified DNA (2009) (0)
Functional Studies of Orphan Enzymes by LC‐MS Based Metabolomics: Oxidation of Endogenous N‐Arachidonoylserotonin by Human Cytochrome P450 2U1 (LB174) (2014) (0)
Stability of cytochrome P450 enzymes in human liver samples stored in different tissue preservation buffers. (2002) (0)
Purification of Cytochrome P‐450 Enzymes (1999) (0)
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite an 8-Oxoguanine Lesion (2015) (0)
Erratum Comparison of the biotransfonnation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice (2004) (0)
Oxidation of indole by human cytochrome P450 enzymes (2000) (0)
Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes. (2001) (0)
Frequency of DNA Damage (2014) (0)
STEREOSELECTIVE BINDING OF CHIRAL 7-CHLORO-1,3-DIHYDRO-3-(S- AND R)-ISOPROPYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE TO HUMAN SERUM ALBUMIN (1980) (0)
Prognostički i dijagnostički testovi odabranih bolesti jetre (2002) (0)
Substrate specificities and stereoselectivities of 7 purified isozymes of rat liver cytochrome p 450 (1982) (0)
Human P450 Metabolism Database (2020) (0)
Human P450 Metabolism Database - Updated (2004) (0)
Characterization of Thioether‐Linked Protein Adducts of DNA Using a Raney‐Ni‐Mediated Desulfurization Method and Liquid Chromatography‐Electrospray‐Tandem Mass Spectrometry (2015) (0)
The Cytochrome P450 Database (2020) (0)
Testing urine for drugs. (1992) (0)
Kinetic Analysis of the Processivity of Human Cytochrome P450 17A1 (2015) (0)
Human metabolic databases for drug development and drug interactions (2007) (0)
New clues in the acetaminophen mystery (2005) (0)
Bypass and Misincorporation of DNA Polymerases at DNA‐Peptide Crosslinks (2017) (0)
They defend the body against environmental pollutants, detoxify drugs and synthesize several important signaling molecules (2016) (0)
Chapter 3. Structural Multiplicity and Functional Versatility of Cytochrome P-450 (1989) (0)
Random mutagenesis by whole-plasmid PCR amplification. (2002) (0)
How I became a biochemist (2005) (0)
Oxidative Inhibition of the ω‐Hydroxylation Activity of Cytochrome P450 4A11 by Sulfenylation of the Heme‐Thiolate Cysteine (2017) (0)
Chapter 21:Metabolism-Based Toxicology Prediction (2011) (0)
Kinetic analysis of steps involved in oxidation by cytochrome P450 19A1 (2010) (0)
Enzymatic Transformations: Enzymatic Basis of Detoxication . William B. Jakoby, Ed. Academic Press, New York, 1980. In two volumes. Vol. 1. xvi, 416 pp. $43. Vol. 2. xiv, 370 pp. $38.50. Biochemical Pharmacology and Toxicology. (1981) (0)
Human Metabolism Databases - Updated (2002) (0)
A Fluorescence Spectroscopic Study of Cytochromes P450 1A2 and 3A4. (2006) (0)
Bioactivation of Dibromoethane by Conjugation with Glutathione (1991) (0)
Toxicogenomics and pharmacogenomics: basic principles, potential applications, and issues (2002) (0)
The role of Arg332 in Dpo4‐catalyzed bypass of 7,8‐dihydro‐2′‐oxodeoxyguanosine (2007) (0)
Mechanism‐Based Inhibition of Human Cytochrome P450 2D6 by Schering 66712 (2010) (0)
Expressed P450s in toxicity assays (2001) (0)
Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4 and relevance to substrate cooperativity (2006) (0)
Discovery of a role for cytochrome b5 in cytochrome P450 reactions. (2022) (0)
Working Toward Reducing Bias in Peer Review (2021) (0)
Drug Metabolism and Toxicology Special Issue Call for Papers. (2019) (0)
Inhibition of Human Cytochrome P450 2D6 by Schering 66712 (2007) (0)
Positive cooperativity in catalysis of pyrene 1‐hydroxylation by cytochrome P450 1A2 (2008) (0)
Drug Metabolism and Toxicology Special Issue Call for Papers. (2019) (0)
FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients (2023) (0)
Mitochondria‐Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic‐Induced Toxicity (2018) (0)
Biochemistry and metabolism of drugs of abuse as related ot their pharmacological activity, interactions with receptors and analysis (1990) (0)
Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1). (2023) (0)
Organic Explosives as Dangerous Environmental Xenobiotics - QSAR Study (1996) (0)
Hydrolytic, Deamination, and Rearrangement Reactions of DNA Adducts (2014) (0)
Guest editor's introduction. Special issue on catalytic mechanisms. (2011) (0)

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