Fabienne Mackay | Academic Influence

Fabienne Mackay's AcademicInfluence.com Rankings

Fabienne Mackay

Biology

#11718

World Rank

#15138

Historical Rank

Immunology

#884

World Rank

#907

Historical Rank

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Biology

Fabienne Mackay's Degrees

Bachelors Biology University of California, Berkeley
PhD Immunology Stanford University

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Why Is Fabienne Mackay Influential?

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According to Wikipedia, Fabienne Mackay is a French Australian research immunologist and institutional leader within the Australian medical research, education and innovation sectors. She is the Director and CEO of the QIMR Berghofer Medical Research Institute since 2020, after being the inaugural Head of the School of Biomedical Sciences at the University of Melbourne during the preceding five years. She is also an Honorary Professor at the Faculties of Medicine of the University of Queensland and the University of Melbourne. Her work has attracted public attention for its contribution to the pathophysiological understanding and treatment of lupus and other autoimmune diseases. Mackay has been notably awarded, achieving international reputation for her widely cited research describing B-cell activating factor and other cytokines of the TNF receptor superfamily, and their roles in B cell physiology, autoimmunity and cancer. She is an elected Fellow of the Australian Academy of Health and Medical Sciences.

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Fabienne Mackay's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 (2009) (2462)
Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations (1999) (1531)
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth (1999) (1368)
BAFF AND APRIL: a tutorial on B cell survival. (2003) (951)
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. (2002) (915)
Cracking the BAFF code (2009) (869)
Baff Mediates Survival of Peripheral Immature B Lymphocytes (2000) (758)
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. (2004) (737)
BAFF: A fundamental survival factor for B cells (2002) (687)
Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 (2007) (625)
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes (2004) (570)
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. (2013) (522)
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells. (2003) (506)
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs (1996) (431)
Control systems and decision making for antibody production (2010) (421)
Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population (2000) (400)
Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55 (1993) (396)
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation (2011) (389)
BAFF and MyD88 signals promote a lupuslike disease independent of T cells (2007) (374)
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. (2000) (372)
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells1 (2004) (364)
Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective (2012) (344)
The BAFF/APRIL system in SLE pathogenesis (2014) (334)
The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity (2013) (319)
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. (2008) (299)
Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor (1998) (299)
Targeted Inactivation of Gh/Tissue Transglutaminase II* (2001) (291)
B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. (2007) (291)
Mcl-1 is essential for the survival of plasma cells (2013) (273)
Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness (2011) (273)
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells. (2019) (264)
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (2009) (263)
B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation (2004) (257)
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1 (2006) (257)
Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie (2000) (255)
Maturation of Marginal Zone and Follicular B Cells Requires B Cell Activating Factor of the Tumor Necrosis Factor Family and Is Independent of B Cell Maturation Antigen (2001) (253)
The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles (1998) (253)
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. (2008) (253)
Turning off follicular dendritic cells (1998) (223)
Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice (1997) (214)
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. (1993) (209)
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 (2019) (208)
The BAFF/APRIL system: an important player in systemic rheumatic diseases. (2005) (193)
A fundamental bimodal role for neuropeptide Y1 receptor in the immune system (2005) (181)
B‐cell stage and context‐dependent requirements for survival signals from BAFF and the B‐cell receptor (2010) (179)
TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma1 (2004) (178)
The TNF family members BAFF and APRIL: the growing complexity. (2003) (173)
Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. (2007) (170)
Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE−/− Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation (2012) (168)
The role of the BAFF/APRIL system on T cell function. (2006) (165)
The BAFF/APRIL system: life beyond B lymphocytes. (2005) (163)
Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. (1998) (160)
Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines (1996) (158)
Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling (2004) (156)
TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. (2008) (152)
BAFF Augments Certain Th1-Associated Inflammatory Responses1 (2005) (144)
Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. (1998) (133)
Marginal-Zone B-Cells of Nonobese Diabetic Mice Expand With Diabetes Onset, Invade the Pancreatic Lymph Nodes, and Present Autoantigen to Diabetogenic T-Cells (2008) (128)
Clinical associations of serum interleukin-17 in systemic lupus erythematosus (2013) (128)
The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers. (2004) (125)
TNF ligands and receptors in autoimmunity: an update. (2002) (116)
BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. (2005) (116)
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells (2008) (112)
NPY and receptors in immune and inflammatory diseases. (2007) (112)
The anti‐apoptotic factor Bcl‐2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF (2004) (106)
Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses (2009) (105)
Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. (2006) (99)
B-cell tolerance breakdown in Sjögren's syndrome: focus on BAFF. (2010) (99)
The Tetraspanin CD37 Orchestrates the α4β1 Integrin–Akt Signaling Axis and Supports Long-Lived Plasma Cell Survival (2012) (93)
The role of BAFF in B-cell maturation, T-cell activation and autoimmunity. (2002) (87)
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells (2009) (87)
BAFF costimulation of Toll‐like receptor‐activatedB‐1 cells (2006) (87)
BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus (2012) (83)
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (2005) (80)
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8− dendritic cells require the intramembrane endopeptidase SPPL2A (2013) (80)
Increased Expression of CD27 on Activated Human Memory B Cells Correlates with Their Commitment to the Plasma Cell Lineage1 (2005) (80)
Development of nephritis but not sialadenitis in autoimmune‐prone BAFF transgenic mice lacking marginal zone B cells (2006) (78)
Association of serum B cell activating factor from the tumour necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) with central nervous system and renal disease in systemic lupus erythematosus (2013) (78)
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells (2015) (75)
Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation. (1994) (72)
Obesity is associated with activated and insulin resistant immune cells (2012) (71)
Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. (2002) (68)
Lymphotoxin β Receptor Triggering Induces Activation of the Nuclear Factor κB Transcription Factor in Some Cell Types* (1996) (68)
CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons (2014) (67)
Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. (2006) (66)
An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome (2007) (65)
Mutation of the BAFF furin cleavage site impairs B‐cell homeostasis and antibody responses (2011) (62)
The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death. (2013) (60)
Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies (2006) (59)
The Y1 receptor for NPY: A key modulator of the adaptive immune system (2007) (56)
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis (2017) (53)
Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. (1995) (53)
Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia (2014) (43)
BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus (2012) (42)
Malaria infection alters the expression of B‐cell activating factor resulting in diminished memory antibody responses and survival (2012) (42)
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers. (2015) (42)
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 (2019) (41)
Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity (2012) (39)
Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes. (1997) (38)
CXC Chemokine Receptor 7 (CXCR7) Regulates CXCR4 Protein Expression and Capillary Tuft Development in Mouse Kidney (2012) (37)
Phenotypic analysis of TNFR1-deficient mice and characterization of TNFR1-deficient fibroblasts in vitro. (1994) (36)
MHC Class II Expression in Human Basophils: Induction and Lack of Functional Significance (2013) (34)
B cells flying solo (2008) (34)
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors (2018) (33)
Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice. (2011) (31)
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells (2016) (31)
CXC Chemokine Receptor 7 (CXCR7) Affects the Migration of GnRH Neurons by Regulating CXCL12 Availability (2013) (31)
BAFF-driven autoimmunity requires CD19 expression. (2015) (30)
Machine learning applied to whole‐blood RNA‐sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus (2019) (30)
Y1 signalling has a critical role in allergic airway inflammation (2011) (30)
The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology (2015) (30)
Roles of ligands from the TNF superfamily in B cell development, function, and regulation. (2014) (29)
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types. (1996) (26)
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation (2017) (26)
Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases (2013) (23)
IL‐10 regulates Aicda expression through miR‐155 (2015) (22)
Travelling with the BAFF/BLyS family: are we there yet? (2006) (21)
Human Tumor Necrosis Factor a (TNF'a) Mutants with Exclusive Specificity for the 55-kDa or 75-kDa TNF' Receptors* (2001) (20)
Analysis of serum B cell‐activating factor from the tumor necrosis factor family (BAFF) and its soluble receptors in systemic lupus erythematosus (2019) (19)
The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice (2014) (19)
Methotrexate and BAFF interaction prevents immunization against TNF inhibitors (2018) (18)
Distinguishing naive‐ from memory‐derived human B cells during acute responses (2019) (16)
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia* (2016) (14)
Chemokine Signaling Controls Integrity of Radial Glial Scaffold in Developing Spinal Cord and Consequential Proper Position of Boundary Cap Cells (2015) (14)
Urinary B-cell-activating factor of the tumour necrosis factor family (BAFF) in systemic lupus erythematosus (2018) (14)
Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus (2018) (11)
Induction of Germinal Centers by MMTV Encoded Superantigen on B Cells (2001) (10)
Gene Therapy Delivery of Myelin Oligodendrocyte Glycoprotein (MOG) via Hematopoietic Stem Cell Transfer Induces MOG-Specific B Cell Deletion (2014) (9)
Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus (2020) (9)
Molecular control of B‐cell homeostasis in health and malignancy (2018) (8)
Protective Effect of Inflammasome Activation by Hydrogen Peroxide in a Mouse Model of Septic Shock (2017) (8)
Tumor Necrosis Factor c ~ ( TNF-c ~ )-induced Cell Adhesion to Human Endothelial Cells Is under Dominant Control of One TNT Receptor Type , TNF-R 55 By (2003) (7)
B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF (2021) (7)
Two Distinct Tumor Necrosis Factor Receptors in Health and Disease (1993) (6)
Serum soluble Fas and Fas ligand (FasL) in primary Sjögren's syndrome. (2019) (3)
BAFF AND APRIL: AT utorial on BC ell Survival (2003) (3)
The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology (2015) (3)
Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (2010) (3)
Editorial overview: Autoimmunity. (2015) (2)
Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation (2020) (2)
Blocking of BAFF signaling pathway by BCMA-Fc attenuates autoimmune manifestations in BAFF transgenic mice and reveals its important role in maintaining peripheral B cell homeostasis. (2000) (2)
The BAFF/APRIL System in Autoimmunity (2009) (1)
B Cells and Autoimmunity (2006) (1)
Signaling through the Lymphotoxin 13 Receptor Induces the Death of Some Adenocarcinoma Tumor Lines By Jeffrey L. Browning, Konrad Miatkowski, Irene Sizing, (1996) (1)
The effects of B‐cell–activating factor on the population size, maturation and function of murine natural killer cells (2022) (1)
Reveals a Predisposition to B Cell Lymphoma Transgenic Mice against Autoimmunity and TNF Deficiency Fails to Protect BAFF (2003) (1)
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors (2018) (1)
Efficient conditional gene expression following transplantation of retrovirally transduced bone marrow stem cells. (2015) (1)
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis (2017) (1)
Special Focus on malaria (2000) (1)
Temporal depletion of B cells, by selectively targeting BAFF, prevents diabetes in NOD mice (2005) (1)
THE PATTERN OF THE HUMAN VENTILATORY RESPONSE TO TRANSIENT HYPOXIA (1980) (1)
Circulating T and B Cells Receptor Facilitating BAFF Costimulation of BAFFTNF Family ( BAFF )-R Is the Principal B Cell-Activating Factor Belonging to the (2004) (1)
Not from Venus, not from Mars — all equally superstars (2020) (1)
Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence (2021) (1)
345 Deletion of the baff receptor taci fully protects against sle without reduction of b cell numbers and function (2017) (1)
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation (2017) (1)
Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization. (2022) (1)
Corrigendum: Mcl-1 is essential for the survival of plasma cells (2013) (1)
This Week in The Journal (2015) (0)
Long‐term exposure to monoclonal anti‐TNF is associated with an increased risk of lymphoma in BAFF‐transgenic mice (2021) (0)
97 Deletion of taci protects against autoimmune disease in lupus-prone mouse models with different disease mechanisms (2017) (0)
Use of BAFF for the treatment of Th2-mediated conditions (2006) (0)
The role of BAFF in Autoimmunity is T cell‐independent but requires MyD88 signalling. (2008) (0)
Long-term exposure to monoclonal anti-TNF is associated with an increased risk of lymphoma in BAFF-transgenic mice (2020) (0)
Inflammatory Responses BAFF Augments Certain Th1-Associated (2005) (0)
GENERATING ALLOGRAFT TOLERANCE BY BAFF- DEPENDANT EXPANSION OF REGULATORY T CELLS: 736 (2008) (0)
Treatment of BAFF Transgenic Mice with Anti-TNF: Monoclonals Are Associated with a Higher Risk of Lymphoma Than Etanercept (2016) (0)
The role of BAFF in the biology of NK cells (2019) (0)
MUTATIONS IN THE INTRAMEMBRANE ENDOPEPTIDASE SPPL2A AFFECT HUMORAL IMMUNITY AND B-CELL SURVIVAL BY REDUCING SURFACE BCR AND BAFF-R EXPRESSION AND AFFECTING CD74 METABOLISM (2012) (0)
The novel cytokine Interferon Lambda and its contribution to Systemic Lupus Erythematosus (2018) (0)
The bigger B cell picture (2016) (0)
The BAFF-APRIL System in Cancer (2023) (0)
Induction of germinal center formation in mmtv-vSAg7 expressing B cells by vSAg7 responsive T cells (2000) (0)
Cxcr7 controls chemotaxis in migrating cortical interneurons (2010) (0)
Modulation of the alloimmune response by BAFF (2005) (0)
P028 Treatment of BAFF transgenic mice with ANTI-TNF: monoclonal ANTI-TNF are associated with a higher risk of lymphoma than etanercept (2017) (0)
MOG-Specific B Cell Deletion Hematopoietic Stem Cell Transfer Induces Oligodendrocyte Glycoprotein (MOG) via Gene Therapy Delivery of Myelin (2014) (0)
Baff, inhibitors and their use in modulating the response of cells b. (2000) (0)
Gut Microbiota and Atrial Fibrillation: Pathogenesis, Mechanisms and Therapies (2023) (0)
Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8+T cells (2020) (0)
Baff stimulates Nogo receptor 1 and 3 expressed on b cells within spinal cord follicle-like structures formed during EAE (2019) (0)
The flavin binding sub-domains of rat neuronal nitric oxide synthase (2002) (0)
CD8+ T Cells Promote Pathological Angiogenesis in Ocular Neovascular Disease (2023) (0)
Not from Venus, not from Mars — all equally superstars (2020) (0)
BAFF, inhibitors and their use in modulating the B-cell response (2000) (0)
A role for BAFF in the development of Sjogren's syndrome through recruitment of B cells with a marginal zone-like phenotype (2001) (0)
Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor (2022) (0)
A chemokine receptor CXCR7 non-cell-autonomously controls migration and nuclei formation of pontine neurons from the migratory environment (2011) (0)
BAFF alters T-cell-dependant immune responses allowing allograft acceptance (2008) (0)
OP0307 Treatment of baff transgenic mice with ANTI-TNF: monoclonal ANTI-TNF are associated with a higher risk of lymphoma than etanercept (2017) (0)
Modulation of the T cell dependent alloimmune response by BAFF (2005) (0)
Proper segregation and connection between the CNS and PNS require SDF-1/CXCR4/CXCR7 signaling trio (2009) (0)
Tissue remodeling and cell signaling underpin changes in tumor microenvironment heterogeneity in glioma oncogenesis (2021) (0)
36 Identification of disease-associated gut microbiota in lupus-prone baff-tg mice (2017) (0)
Erratum: Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage (Journal of Immunology (2005) 174 (4034-4042)) (2005) (0)
S-15 : Cytokine-driven loss of plasmacytoid dendritic cell function in chronic lymphocytic leukemia (2014) (0)
THE PROTECTIVE EFFECTS OF ANGIOTENSIN TYPE 1 RECEPTOR BLOCKADE IN ISCHEMIC RETINOPATHY IS INFLUENCED BY FOXP3 TREGS (2013) (0)

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What Schools Are Affiliated With Fabienne Mackay?

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