Fernand Labrie
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Canadian medical researcher
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(Suggest an Edit or Addition)According to Wikipedia, Fernand Labrie, was a Canadian medical researcher who specializes in endocrinological research and prostate cancer research. Life and career Born in Laurierville, Quebec, he received a Bachelor of Arts degree in 1957 from the Séminaire de Québec. He received his Doctor of Medicine in 1962 and a Ph.D. in 1966 from Université Laval. From 1966 to 1969, he took his postdoctoral studies at the University of Cambridge and the University of Sussex.
Fernand Labrie's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of late-onset hypogonadism in middle-aged and elderly men. (2010) (1176)
- Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. (1997) (957)
- The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds (1996) (866)
- Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. (1997) (715)
- A candidate prostate cancer susceptibility gene at chromosome 17p (2001) (568)
- Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. (2003) (534)
- Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. (1999) (501)
- Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. (2010) (473)
- Is dehydroepiandrosterone a hormone? (2005) (454)
- Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs. (2000) (437)
- A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening. (1995) (433)
- Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. (1994) (422)
- The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology (1997) (411)
- Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release. (1978) (378)
- Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. (1997) (358)
- DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging (1998) (350)
- DHEA and Its Transformation into Androgens and Estrogens in Peripheral Target Tissues: Intracrinology (2001) (348)
- Serum prostate specific antigen as pre-screening test for prostate cancer. (1992) (348)
- The Dense LDL Phenotype: Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men (1996) (347)
- Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-lsomerase in Human Adrenals and Gonads (1991) (345)
- Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release. (1978) (338)
- Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists. (1982) (337)
- Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families (1994) (325)
- Intracrinology (1991) (322)
- Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer. (1997) (311)
- Complete androgen blockade for the treatment of prostate cancer. (1985) (311)
- Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. (1997) (302)
- Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease. (2000) (295)
- Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women (2006) (287)
- Full Length cDNA Structure and Deduced Amino Acid Sequence of Human β-Hydroxy-5-Ene Steroid Dehydrogenase (1989) (287)
- New approach in the treatment of prostate cancer: Complete instead of partial withdrawal of androgens (1983) (281)
- Screening decreases prostate cancer death: First analysis of the 1988 Quebec Prospective Randomized Controlled Trial (1999) (279)
- New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen. (1982) (277)
- DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology (1995) (270)
- Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. (2011) (270)
- Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture. (1976) (258)
- Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). (2012) (258)
- Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues (1986) (249)
- High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden. (2011) (246)
- Physiological role of somatostatin in the control of growth hormone and thyrotropin secretion. (1976) (242)
- Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans (2003) (242)
- Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution. (1995) (240)
- Characteristics of human types 1, 2 and 3 17β-hydroxysteroid dehydrogenase activities: Oxidation/reduction and inhibition (1995) (234)
- Antifertility effects of LHRH agonists in the male rat and inhibition of testicular steroidogenesis in man. (1980) (231)
- Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men. (1989) (231)
- Modulation of pituitary thyrotropin releasing hormone receptor levels by estrogens and thyroid hormones. (1977) (225)
- Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line. (1986) (224)
- Older Men With Low Serum Estradiol and High Serum SHBG Have an Increased Risk of Fractures (2008) (219)
- Screening decreases prostate cancer mortality: 11‐year follow‐up of the 1988 Quebec prospective randomized controlled trial (2004) (218)
- Increase in plasma high-density lipoprotein concentration following complete androgen blockage in men with prostatic carcinoma. (1987) (216)
- Comparison of crystal structures of human androgen receptor ligand‐binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity (2006) (212)
- Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues (1992) (211)
- Development of the hypothalamic-pituitary-thyroid axis in the neonatal rat. (1975) (210)
- Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. (2004) (210)
- Congenital adrenal hyperplasia due to point mutations in the type II 3β–hydroxysteroid dehydrogenase gene (1992) (209)
- Low serum testosterone and estradiol predict mortality in elderly men. (2009) (208)
- Androgen receptor antagonists (antiandrogens): structure-activity relationships. (2000) (208)
- Immunohistochemical Localization of β-Lipotropic Hormone in the Pituitary Gland (1977) (206)
- The impact of family history on early detection of prostate cancer (1995) (193)
- Structure of human type II 5 alpha-reductase gene. (1992) (192)
- Androgen biosynthetic pathways in the human prostate. (2008) (190)
- All sex steroids are made intracellularly in peripheral tissues by the mechanisms of intracrinology after menopause (2015) (188)
- Estradiol-induced increase of the LH responsive to LH releasing hormone (LHRH) in rat anterior pituitary cells in culture. (1976) (187)
- Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women (2009) (187)
- Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause (2016) (187)
- Treatment of prostate cancer with gonadotropin-releasing hormone agonists. (1986) (184)
- Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs. (1982) (184)
- Reduced testosterone and adrenal C19 steroid levels in obese men. (1995) (180)
- Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone. (1972) (178)
- Inhibition of testicular luteinizing hormone receptor level by treatment with a potent luteinizing hormone-releasing hormone agonist of human chorionic gonadotropin. (1977) (177)
- A physiologic role for testosterone in limiting estrogenic stimulation of the breast (2003) (176)
- Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies. (2004) (175)
- Structure of two in tandem human 17β-hydroxysteroid dehydrogenase genes (1990) (173)
- Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4isomerase(3β-HSD), 17β-HSD5α-reductase and aromatase activities in the rhesus monkey (1994) (173)
- Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women. (2006) (172)
- Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy (2009) (171)
- Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. (1990) (171)
- Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate. (1988) (171)
- The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form. (1985) (170)
- Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone. (2005) (169)
- Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. (2011) (168)
- EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium (1999) (166)
- DHEA, important source of sex steroids in men and even more in women. (2010) (165)
- Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. (1994) (164)
- Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate (1985) (159)
- Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men. (2012) (158)
- Effect of neoadjuvant endocrine therapy (combined androgen blockade) on normal prostate and prostatic carcinoma. A randomized study. (1996) (158)
- The intracrine sex steroid biosynthesis pathways. (2010) (157)
- Stimulation of cyclic AMP accumulation and corticotropin release by synthetic ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action. (1982) (155)
- Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in advanced prostate cancer: a marked improvement in response and survival. (1985) (155)
- Gonadotropin-releasing hormone agonists in the treatment of prostate cancer. (2005) (154)
- Molecular mass and carbohydrate structure of prostate specific antigen: Studies for establishment of an international PSA standard (1995) (153)
- Role of 17β-Hydroxysteroid Dehydrogenases in Sex Steroid Formation in Peripheral Intracrine Tissues (2000) (147)
- Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex (1999) (147)
- Potent inhibitory activity of [D-Leu6, Des-Gly-NH2(10)]LHRH ethylamide on LH/hCG and PRL testicular receptor levels in the rat. (1977) (146)
- Stimulation of prolactin release in the rat by intraventricular injection of beta-endorphin and methionine-enkephalin. (1977) (141)
- Electron microscopic immunohistochemical localization of growth hormone-release inhibiting hormone (somatostatin) in the rat median eminence. (1974) (140)
- Inhibition of adenosine 3',5'-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone. (1974) (140)
- (S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen. (1997) (139)
- Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues (1992) (139)
- Localization of Type 5 17β-Hydroxysteroid Dehydrogenase, 3β-Hydroxysteroid Dehydrogenase, and Androgen Receptor in the Human Prostate by in Situ Hybridization and Immunocytochemistry. (1999) (139)
- Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations. (1996) (137)
- Inhibitory Effect of LHRH and Its Agonists on Testicular Gonadotrophin Receptors and Spermatogenesis in the Rat (1978) (137)
- Estradiol Is Required for a Proper Immune Response to Bacterial and Viral Pathogens in the Female Brain 1 (2005) (136)
- Inhibitory effects of long term treatment with a luteinizing hormone-releasing hormone agonist on the pituitary-gonadal axis in male and female rats. (1979) (136)
- The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. (1997) (134)
- Structure of the human type II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) gene : adrenal and gonadal specificity (1991) (132)
- Steroid hormone receptors and pharmacology. (1980) (132)
- Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary? (2011) (131)
- Treatment of hirsutism with the pure antiandrogen flutamide. (1990) (130)
- Adrenal androgens and intracrinology. (2004) (130)
- Response to flutamide withdrawal in advanced prostate cancer in progression under combination therapy. (1993) (128)
- Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators. (1998) (128)
- Inhibition of serum androgen levels by chronic intranasal and subcutaneous administration of a potent luteinizing hormone-releasing hormone (LH-RH) agonist in adult men. (1982) (127)
- Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin. (1976) (125)
- Effect of chronic estradiol and haloperidol treatment on striatal dopamine receptors. (1981) (124)
- Activity of two new potent dopaminergic agonists at the striatal and anterior pituitary levels (1980) (122)
- Intracrinology and The Skin (2001) (122)
- Mechanism of action and pure antiandrogenic properties of flutamide (1993) (122)
- Effect of Combination Endocrine Therapy (LHRH Agonist and Flutamide) on Normal Prostate and Prostatic Adenocarcinoma: A Histopathologic and Immunohistochemical Study (1991) (122)
- Vasopressin potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture. (1982) (122)
- Metabolism of DHEA in postmenopausal women following percutaneous administration (2007) (121)
- Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients. (1992) (121)
- Beta-endorphin: stimulation of growth hormone release in vivo. (1977) (120)
- Are there any sensitive and specific sex steroid markers for polycystic ovary syndrome? (2010) (119)
- Are women with Sjögren's syndrome androgen-deficient? (2003) (118)
- Comparable amounts of sex steroids are made outside the gonads in men and women: Strong lesson for hormone therapy of prostate and breast cancer (2009) (118)
- A sensitive, simple and robust LC–MS/MS method for the simultaneous quantification of seven androgen- and estrogen-related steroids in postmenopausal serum (2014) (117)
- Characteristics of the interaction between thyrotropin-releasing hormone and somatostatin for thyrotropin and prolactin release. (1976) (117)
- Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line (1988) (114)
- Flutamide eliminates the risk of disease flare in prostatic cancer patients treated with a luteinizing hormone-releasing hormone agonist. (1987) (114)
- Prostate cancer susceptibility genes: lessons learned and challenges posed. (2003) (112)
- Downstaging of localized prostate cancer by neoadjuvant therapy with flutamide and lupron: the first controlled and randomized trial. (1993) (112)
- Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer. (1990) (111)
- Extremely rapid degradation of [3H] methionine-enkephalin by various rat tissues in vivo and in vitro. (1977) (111)
- Extragonadal synthesis of sex steroids: intracrinology. (2003) (111)
- Relationships between endogenous steroid hormone, sex hormone-binding globulin and lipoprotein levels in men: contribution of visceral obesity, insulin levels and other metabolic variables. (1997) (111)
- Subunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta. (1992) (111)
- Type 5 17β-hydroxysteroid dehydrogenase: its role in the formation of androgens in women (2001) (110)
- Characteristics of the α-Adrenergic Stimulation of Adrenocorticotropin Secretion in Rat Anterior Pituitary Cells (1981) (110)
- Corticotropin-releasing factor stimulates secretion of melanocyte-stimulating hormone from the rat pituitary. (1982) (110)
- Crystal structure of human estrogenic 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol (1996) (110)
- Characterization, Expression, and Immunohistochemical Localization of 5α-Reductase in Human Skin (1994) (110)
- Science behind total androgen blockade: from gene to combination therapy. (1993) (109)
- Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line. (1989) (109)
- Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women (2009) (108)
- Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. (2001) (107)
- Effect of prolactin and estradiol on rat striatal dopamine receptors. (1982) (107)
- Acute stimulatory effects of progesterone on luteinizing hormone and follicle-stimulating hormone release in rat anterior pituitary cells in culture. (1980) (107)
- Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. (2013) (106)
- Similar luteinizing hormone-releasing hormone binding sites in rat anterior pituitary and ovary. (1980) (105)
- MOLECULAR BASIS OF CONGENITAL ADRENAL HYPERPLASIA DUE TO 3β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY (1993) (105)
- Immunocytochemical Localization of Type 5 17 β-Hydroxysteroid Dehydrogenase in Human Reproductive Tissues (1999) (105)
- Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. (1989) (104)
- Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25. (1989) (104)
- Immunohistochemical localization of luteinizing hormone-releasing hormone in the rat median eminence. (1974) (103)
- Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride (2010) (103)
- Down-staging of early stage prostate cancer before radical prostatectomy: The first randomized trial of neoadjuvant combination therapy with flutamide and a luteinizing hormone-releasing hormone agonist (1994) (102)
- Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. (1986) (102)
- Inhibition of spermatogenesis in the rat by treatment with [D-Ala6, Des-Gly-NH210] LHRH ethylamide. (1978) (102)
- Hormonal therapy of prostate cancer. (2010) (102)
- Localization of growth hormone-release-inhibiting hormone (somatostatin) in the rat brain. (1975) (101)
- Unique features of the basal cells of human prostate epithelium (2000) (100)
- Evidence for geographical and racial variation in serum sex steroid levels in older men. (2010) (99)
- Role of androgens in women's sexual dysfunction (2010) (99)
- Analysis of the androgenic activity of synthetic "progestins" currently used for the treatment of prostate cancer. (1987) (98)
- Age-dependent changes in the β-endorphin content of discrete rat brain nuclei (1981) (98)
- Binding of thyrotropin-releasing hormone to plasma membranes of bovine anterior pituitary gland (hormone receptor-adenylate cyclase-equilibrium constant-( 3 H)thyrotropin). (1972) (98)
- Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women (2008) (97)
- Structure and tissue-specific expression of 3ß-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues (1992) (97)
- SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. (2006) (95)
- Effects of estrogens on the characteristics of [3H]spiroperidol and [3H]RU24213 binding in rat anterior pituitary gland and brain (1979) (95)
- Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. (1988) (95)
- Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH) (1976) (95)
- Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration (2009) (94)
- Vasopressin rapidly stimulates phosphatidic acid‐phosphatidylinositol turnover in rat anterior pituitary cells (1985) (94)
- Age-related changes in central nervous system enkephalins and substance P. (1981) (93)
- Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first‐line therapy (1993) (93)
- beta-Endorphin and met-enkephalins: their distribution, modulation by estrogens and haloperidol, and role in neuroendocrine control. (1980) (92)
- Blockade of testicular and adrenal androgens in prostate cancer treatment (2011) (92)
- Can combined androgen blockade provide long-term control or possible cure of localized prostate cancer? (2002) (91)
- Oestrogenic Regulation of Pro‐Opiomelanocortin, Neuropeptide Y and Corticotrophin‐Releasing Hormone mRNAs in Mouse Hypothalamus (2007) (91)
- Neoadjuvant hormonal therapy: the Canadian experience. (1997) (91)
- A new approach in the hormonal treatment of prostate cancer: complete instead of partial blockade of androgens. (1984) (91)
- Characterization, Expression, and Immunohistochemical Localization of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase in Human Skin (1992) (90)
- Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells. (1991) (90)
- An LHRH agonist inhibits FSH-induced cyclic AMP accumulation and steroidogenesis in porcine granulosa cells in culture. (1980) (90)
- Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men. (2010) (89)
- Specific binding of a potent LHRH agonist in rat testis (1980) (89)
- Androgen Receptor Targeted Treatments of Prostate Cancer: 35 Years of Progress with Antiandrogens (2018) (89)
- Additive effects of epinephrine and corticotropin-releasing factor (CRF) on adrenocorticotropin release in rat anterior pituitary cells. (1983) (88)
- Potent prolactin and growth hormone releasing activity of more analogues of Met-enkephalin (1977) (87)
- Down-regulation of testicular androgen biosynthesis and LH receptor levels by an LHRH agonist: role of prolactin (1979) (86)
- Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations. (2009) (86)
- Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice. (1991) (85)
- Structure and sexual dimorphic expression of a liver-specific rat 3 beta-hydroxysteroid dehydrogenase/isomerase. (1990) (84)
- In vitro interactions of gastrointestinal hormones on cyclic adenosine 3':5'-monophosphate levels and amylase output in the rat pancreas. (1975) (84)
- CRF stimulates α-MSH secretion and cyclic AMP accumulation in rat pars intermedia cells (1982) (84)
- Changes in plasma lipoproteins during various androgen suppression therapies in men with prostatic carcinoma: effects of orchiectomy, estrogen, and combination treatment with luteinizing hormone-releasing hormone agonist and flutamide. (1988) (84)
- Molecular Cloning of Human Type 3 3α-Hydroxysteroid Dehydrogenase That Differs from 20α-Hydroxysteroid Dehydrogenase by Seven Amino Acids (1996) (84)
- Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration (1988) (83)
- EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β. (1998) (82)
- Structure and tissue-specific expression of a novel member of the rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) family. The exclusive 3 beta-HSD gene expression in the skin. (1993) (82)
- Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin. (1977) (82)
- Interactions between 17 beta-estradiol and progesterone in the control of luteinizing hormone and follicle-stimulating hormone release in rat anterior pituitary cells in culture. (1981) (81)
- 11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues (1994) (80)
- Synthesis and biological activity of new halo-steroidal antiestrogens. (1991) (80)
- DHEA and intracrinology at menopause, a positive choice for evolution of the human species (2013) (79)
- Inhibitory effect of a luteinizing hormone (LH)-releasing hormone agonist on rat ovarian LH and follicle-stimulating hormone receptor levels during pregnancy. (1978) (79)
- Novel compounds inhibit estrogen formation and action. (1992) (79)
- Evaluation of prostatic specific antigen and digital rectal examination as screening tests for prostate cancer (2000) (78)
- Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs (1979) (78)
- Treatment of pain at sexual activity (dyspareunia) with intravaginal dehydroepiandrosterone (prasterone) (2015) (78)
- Serum Levels of Specific Glucuronidated Androgen Metabolites Predict BMD and Prostate Volume in Elderly Men (2006) (78)
- Possible luteolytic effects of luteinizing hormone-releasing hormone in normal women. (1979) (77)
- Diagnosis of advanced or noncurable prostate cancer can be practically eliminated by prostate-specific antigen. (1996) (77)
- The relationships between sex hormones and sexual function in middle-aged and older European men. (2011) (77)
- Characterization of the effects of the novel non‐steroidal antiestrogen EM‐800 on basal and estrogen‐induced proliferation of T‐47D, ZR‐75‐1 and MCF‐7 human breast cancer cells in vitro (1997) (77)
- Ligand-independent Activation of the Estrogen Receptors α and β by Mutations of a Conserved Tyrosine Can Be Abolished by Antiestrogens (1998) (77)
- Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase. (2000) (77)
- Widespread tissue distribution of steroid sulfatase, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD 5 alpha-reductase and aromatase activities in the rhesus monkey. (1994) (76)
- Benefits of combination therapy with flutamide in patients relapsing after castration. (1988) (76)
- Changes in plasma lipoprotein and apolipoprotein composition in relation to oral versus percutaneous administration of estrogen alone or in cyclic association with utrogestan in menopausal women. (1991) (76)
- Changes of cell morphology and prolactin secretion induced by 2-Br- alpha-ergocryptine, estradiol, and thyrotropin-releasing hormone in rat anterior pituitary cells in culture (1980) (76)
- The pure antiandrogen ru 23908 (anandron®), a candidate of choice for the combined antihormonal treatment of prostatic cancer: A review (1984) (76)
- Relation of Steroid Hormones to Glucose Tolerance and Plasma Insulin Levels in Men: Importance of visceral adipose tissue (1995) (76)
- Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells. (1997) (76)
- Effects of the estrogen antagonist EM-652.HCl on energy balance and lipid metabolism in ovariectomized rats (2000) (75)
- Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. (1979) (75)
- Intravaginal dehydroepiandrosterone (prasterone), a highly efficient treatment of dyspareunia (2011) (75)
- Perspective: prostate cancer susceptibility genes. (2002) (75)
- Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™ (2009) (74)
- Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women (1996) (74)
- Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3β‐hydroxy‐5‐ene steroid dehydrogenase/Δ5‐Δ4 isomerase (1989) (73)
- Prolonged neoadjuvant combined androgen blockade leads to a further reduction of prostatic tumor volume: three versus six months of endocrine therapy. (1999) (73)
- Androgens decrease LHRH binding sites in rat anterior pituitary cells in culture. (1981) (73)
- Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. (2003) (72)
- Human Types 1 and 3 3α-Hydroxysteroid Dehydrogenases: Differential Lability and Tissue Distribution1 (2001) (72)
- Changes of pituitary thyrotropin releasing hormone (TRH) receptor level and prolactin response to TRH during the rat estrous cycle. (1977) (72)
- Inhibition of basal and adrenocorticotropin-stimulated plasma levels of adrenal androgens after treatment with an antiandrogen in castrated patients with prostatic cancer. (1984) (71)
- Localization of oestrogen receptor (cid:1) , oestrogen receptor (cid:2) and androgen receptors in the rat reproductive organs (2000) (71)
- Immunocytochemical Localization of 5α-Reductase in Rat Brain (1994) (70)
- Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads. (1991) (70)
- Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues. (2004) (70)
- Assignment of the human 3 beta-hydroxysteroid dehydrogenase gene (HSDB3) to the p13 band of chromosome 1. (1989) (70)
- Molecular basis of human 3β-hydroxysteroid dehydrogenase deficiency (1995) (70)
- Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy. (2015) (70)
- Corticotropin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland (1982) (69)
- Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. (2013) (69)
- The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men. (2007) (69)
- Localization of 3β-Hydroxysteroid Dehydrogenase in Rat Brain as Studied by in Situ Hybridization (1994) (69)
- Role of microtubules in basal and stimulated release of growth hormone and prolactin in rat adenohypophysis in vitro. (1973) (69)
- Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol. (1999) (68)
- Expression of aromatase and 17β-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer An immunocytochemical study (2006) (68)
- Time-course of the effect of treatment with a potent LHRH agonist on testicular steroidogenesis and gonadotropin receptor levels in the adult rat. (1980) (68)
- A wide range of sensitivities to androgens develops in cloned shionogi mouse mammary tumor cells (1986) (67)
- CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant (2001) (67)
- Stimulation of apolipoprotein D secretion by steroids coincides with inhibition of cell proliferation in human LNCaP prostate cancer cells. (1991) (67)
- Identification of gonadotropic cells in the human pituitary by immunoperoxidase technique (1976) (66)
- LHRH rapidly stimulates phosphatidylinositol metabolism in enriched gonadotrophs (1984) (66)
- Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cells (1992) (65)
- Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cells. (1992) (65)
- Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. (1978) (65)
- Distribution of β-lipotropin (β-LPH), adrenocorticotropin (ACTH) and α-melanocyte-stimulating hormone (α-MSH) in the rat brain. I. Origin of the extrahypothalamic fibers (1980) (65)
- Evidence for a role of endorphins in stress- and suckling-induced prolactin release in the rat (1978) (65)
- Inhibition of cell cycle kinetics and proliferation by the androgen 5 alpha-dihydrotestosterone and antiestrogen N,n-butyl-N-methyl-11-[16' alpha-chloro-3',17 beta-dihydroxy-estra-1',3',5'-(10')triene-7' alpha-yl] undecanamide in human breast cancer ZR-75-1 cells. (1991) (64)
- Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology (2017) (64)
- The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. (1995) (64)
- Direct effects of sex steroids on prolactin release at the anterior pituitary level: interactions with dopamine, thyrotropin-releasing hormone, and isobutylmethylxanthine. (1982) (63)
- Rat ovarian epidermal growth factor receptors: Characterization and hormonal regulation (1983) (63)
- Hypothalamus and Endocrine Functions (1976) (63)
- Obesity and metabolic complications: contribution of dehydroepiandrosterone and other steroid hormones. (1996) (63)
- Cellular localization of estrogen receptor beta messenger ribonucleic acid in cynomolgus monkey reproductive organs. (1999) (63)
- The dopamine receptor in the intermediate lobe of the rat pituitary gland is negatively coupled to adenylate cyclase. (1982) (62)
- Comparative effects of 28‐day treatment with the new anti‐estrogen EM‐800 and tamoxifen on estrogen‐sensitive parameters in intact mice (1997) (62)
- Lack of effect of intravaginal dehydroepiandrosterone (DHEA, prasterone) on the endometrium in postmenopausal women (2015) (62)
- Simultaneous administration of pure antiandrogens, a combination necessary for the use of luteinizing hormone-releasing hormone agonists in the treatment of prostate cancer. (1984) (62)
- Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate (1988) (62)
- Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate. (1989) (62)
- Molecular biology and genetics of the 3 beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family. (1996) (62)
- Molecular biology and genetics of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family (1996) (61)
- Effect of exposure to cold on hypothalamic TRH activity and plasma levels of TSH and prolactin in the rat. (1975) (61)
- Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study (2011) (61)
- Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator. (2002) (61)
- Effects of estradiol on intact and denervated striatal dopamine receptors and on dopamine levels: a biochemical and behavioral study. (1982) (61)
- Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast cancer cells. (1989) (60)
- Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat (2000) (60)
- LH-releasing activity of potent LH-RH analogs in vitro. (1975) (60)
- Luteolytic effect of intranasal administration of [D-Ser(TBU)6,DES-Gly-NH2(10)]-luteinizing hormone-releasing hormone ethylamide in normal women. (1979) (60)
- No evidence of mutations in the genes for type I and type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) in nonclassical 3 beta HSD deficiency. (1994) (60)
- Intravaginal prasterone (DHEA) provides local action without clinically significant changes in serum concentrations of estrogens or androgens (2013) (60)
- A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial. (2017) (60)
- Characterization of macaque 3β-hydroxy-5-ene steroid dehydrogenase/Δ5-Δ4 isomerase: structure and expression in steroidogenic and peripheral tissues in primate (1991) (59)
- Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. (1993) (59)
- Inhibition of ovarian luteinizing hormone (LH) and follicle-stimulating hormone receptor levels with an LH-releasing hormone agonist during the estrous cycle in the rat. (1978) (59)
- Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome (2005) (59)
- Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat. (1978) (59)
- Estrogenic activity of phenol red in rat anterior pituitary cells in culture. (1986) (59)
- Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells (1996) (58)
- Serum steroid concentrations remain within normal postmenopausal values in women receiving daily 6.5mg intravaginal prasterone for 12weeks (2016) (58)
- Predictors of sexual desire disorders in women. (2011) (58)
- Regulation of proopiomelanocortin messenger ribonucleic acid content by sex steriods in the arcuate nucleus of the female rat brain (1990) (57)
- Content of beta-LPH and its fragments (including endorphins) in anterior and intermediate lobes of the bovine pituitary gland. (1978) (57)
- Adenohypophyseal secretory granules. I. Their phosphorylation and association with protein kinase. (1971) (57)
- The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer (2006) (56)
- Prolactin inhibits pituitary luteinizing hormone-releasing hormone receptors in the rat. (1982) (56)
- Localization of 3β-Hydroxysteroid DehydrogenaseΔ5-Δ4-Isomerase in Rat Gonads and Adrenal Glands by Immunocytochemistry and in Situ Hybridization (1990) (56)
- Drug Insight: breast cancer prevention and tissue-targeted hormone replacement therapy (2007) (56)
- Science of intracrinology in postmenopausal women (2017) (56)
- Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat. (1998) (56)
- Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. (1993) (56)
- Changes in 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Messenger Ribonucleic Acid, Activity and Protein Levels During the Estrous Cycle in the Bovine Ovary* (1990) (56)
- New Highly Stereoselective Synthesis of (Z)-4-Hydroxytamoxifen and (Z)-4-Hydroxytoremifene via McMurry Reaction. (1996) (55)
- Actinomycin-insensitive stimulation of protein synthesis in rat anterior pituitary in vitro by dibutyryl adenosine 3',5'-monophosphate. (1971) (55)
- Steroid glucuronides: Human circulatory levels and formation by LNCaP cells (1991) (55)
- Effects of dehydroepiandrosterone, Premarin and Acolbifene on histomorphology and sex steroid receptors in the rat vagina (2005) (55)
- Specific binding of [3H]-methyltrienolone to both progestin and androgen binding components in human benign prostatic hypertrophy (BPH). (1979) (55)
- Placental STAT3 signaling is activated in women with polycystic ovary syndrome. (2015) (54)
- Regulation of mRNA expression of 3 beta-hydroxy-5-ene steroid dehydrogenase in porcine granulosa cells in culture: a role for the protein kinase-C pathway. (1990) (54)
- Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (1995) (54)
- Sex steroids, insulin sensitivity and sympathetic nerve activity in relation to affective symptoms in women with polycystic ovary syndrome (2011) (54)
- Inhibition of growth hormone and thyrotropin release by growth hormone-release inhibiting hormone. (1974) (54)
- The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity. (2003) (54)
- Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12* (2007) (54)
- Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells. (1991) (54)
- Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. (2007) (54)
- Immunocytochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human ovary. (1992) (53)
- Atrial natriuretic factor does not affect basal, forskolin- and CRF-stimulated adenylate cyclase activity, cAMP formation or ACTH secretion, but does stimulate cGMP synthesis in anterior pituitary (1986) (53)
- Response of Symbiotic Endomycorrhizal Fungi to Estrogens and Antiestrogens (1997) (53)
- Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Expression and Activity in the Hypophysectomized Rat Ovary: Interactions between the Stimulatory Effect of Human Chorionic Gonadotropin and the Luteolytic Effect of Prolactin* (1990) (53)
- Ontogeny and subcellular localization of 3β-hydroxysteroid dehydrogenase (3β-HSD) in the human and rat adrenal, ovary and testis (1992) (53)
- Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency. (1994) (53)
- Low androgen levels induce the development of androgen-hypersensitive cell clones in Shionogi mouse mammary carcinoma cells in culture. (1988) (53)
- A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: Hormonal control of β-adrenergic receptors and correlation with tumor growth (1991) (52)
- Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program. (2015) (52)
- Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5α-reductase, 20α-hydroxysteroid dehydrogenase and estrogen sulfotransferase (2005) (52)
- Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss. (2016) (52)
- Molecular basis of congenital adrenal hyperplasia in two siblings with classical nonsalt-losing 3 beta-hydroxysteroid dehydrogenase deficiency. (1994) (52)
- Inactivation of the Pure Antiestrogen Fulvestrant and Other Synthetic Estrogen Molecules by UDP-Glucuronosyltransferase 1A Enzymes Expressed in Breast Tissue (2006) (52)
- Mechanism of action of hypothalamic hormones in the adenohypophysis. (1979) (52)
- Comparison of the effects of the antiestrogens EM-800 and tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice. (1998) (52)
- Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men (2013) (52)
- Evidence for distinct dehydrogenase and isomerase sites within a single 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein. (1991) (52)
- Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial. (2016) (51)
- Cloning and expression of cDNA encoding human placental estrogen sulfotransferase (1994) (51)
- Immunocytochemical Localization of Sex Steroid Hormone Receptors in Normal Human Mammary Gland (2010) (51)
- Phosphorylation of adenohypophyseal plasma membranes and properties of associated protein kinase. (1974) (51)
- History of LHRH agonist and combination therapy in prostate cancer (1996) (50)
- Control of protein synthesis in anterior pituitary gland. (1973) (50)
- Inhibitory effects of a single intranasal administration of [D-Ser(TBU)6, des-Gly-NH210]LHRH ethylamide, a potent LHRH agonist, on serum steroid levels in normal adult men. (1980) (50)
- Localization by in situ hybridization of steroid 5alpha-reductase isozyme gene expression in the human prostate and preputial skin. (1998) (50)
- Long term treatment with luteinising hormone releasing hormone agonists and maintenance of serum testosterone to castration concentrations. (1985) (50)
- Effect of Combined Androgen Blockade with an LHRH Agonist and Flutamide in One Severe Case of Male Exhibitionism (1990) (49)
- Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptors (1998) (49)
- Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina. (2004) (49)
- Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland. (2001) (49)
- Structure of the Human 3α-Hydroxysteroid Dehydrogenase Type 3 in Complex with Testosterone and NADP at 1.25-Å Resolution* (2001) (49)
- Mechanisms of androgen production in male pseudohermaphroditism due to 17 beta-hydroxysteroid dehydrogenase deficiency. (1992) (48)
- Expression of liver-specific member of the 3 beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity. (1992) (48)
- Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients. (1996) (48)
- Prasterone has parallel beneficial effects on the main symptoms of vulvovaginal atrophy: 52-week open-label study. (2015) (48)
- Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression. (2004) (48)
- Ultrastructural changes accompanying the stimulatory effect of N6-monobutyryl adenosine 3',5'-monophosphate on the release of growth hormone(GH), prolactin (PRL) and adrenocorticotropic hormone (ACTH) in rat anterior pituitary gland in vitro. (1972) (48)
- Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. (1999) (48)
- Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. (1977) (48)
- COMBINED TREATMENT WITH LHRH AGONIST AND PURE ANTIANDROGEN IN ADVANCED CARCINOMA OF PROSTATE (1984) (48)
- Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase. (1989) (48)
- Multihormonal control of pre-pro-somatostatin mRNA levels in the periventricular nucleus of the male and female rat hypothalamus. (1990) (47)
- Growth hormone-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland. (1983) (47)
- Multiple actions of synthetic ‘progestins’ on the growth of ZR-75-1 human breast cancer cells: Anin vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids (2005) (47)
- Evidence for the regulation of 3 beta-hydroxysteroid dehydrogenase messenger RNA by human chorionic gonadotrophin in luteinized porcine granulosa cells. (1990) (47)
- Specificity of the stimulatory effect of prostaglandins on hormone release in rat anterior pituitary cells in culture. (1976) (47)
- Adenosine 3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. I. Properties. (1971) (47)
- Androgen and glucocorticoid receptor-mediated inhibition of cell proliferation by medroxyprogesterone acetate in ZR-75-1 human breast cancer cells (1989) (47)
- Immunocytochemical localization of type I 17β-hydroxysteroid dehydrogenase in the rat brain (1995) (47)
- Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men (2010) (46)
- Cations Inhibit Specifically Type I 5α-Reductase Found in Human Skin (1995) (46)
- Levels of eighteen non-conjugated and conjugated steroids in human breast cyst fluid: relationships with cyst type. (1990) (46)
- New hormonal treatment in cancer of the prostate: combined administration of an LHRH agonist and an antiandrogen. (1983) (46)
- Light Microscopic Immunocytochemical Localization of 3β-Hydroxy-5-ene-steroid dehydrogenase/Δ5-Δ4- Isomerase in the Gonads and Adrenal Glands of the Guinea Pig (1990) (46)
- Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities. (1999) (46)
- Optimized strategy for detection of early stage, curable prostate cancer: role of prescreening with prostate-specific antigen. (1993) (45)
- EM-652 (SCH57068), a pure SERM having complete antiestrogenic activity in the mammary gland and endometrium (2001) (45)
- Increased testicular 5α-androstane-3α, 17β-diol formation induced by treatment with [D-Ser(TBU)6, des-Gly-NH210]LHRH ethylamide in the rat (1980) (45)
- Effects of chronic treatment with a potent luteinizing hormone releasing hormone agonist on serum luteinizing hormone and steroid levels in the male rhesus monkey. (1982) (45)
- Effects of dihydrotestosterone on skeletal muscle transcriptome in mice measured by serial analysis of gene expression. (2006) (45)
- Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid. (2005) (45)
- Local and systemic reduction by topical finasteride or flutamide of hamster flank organ size and enzyme activity. (1995) (44)
- Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat (1994) (44)
- Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ 5-Δ 4 isomerase (3β-HSD) in human adrenal gland performed by immunocytochemistry (1990) (44)
- Androsterone 3α-Ether-3β-Substituted and Androsterone 3β-Substituted Derivatives as Inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase: Chemical Synthesis and Structure−Activity Relationship (2005) (44)
- Interactions between growth hormone-releasing factor, prostaglandin E2 and somatostatin on cyclic AMP accumulation in rat adenohypophysial cells in culture (1983) (44)
- The 3β-Hydroxysteroid Dehydrogenase/Isomerase Gene Family: Lessons from Type II 3β-HSD Congenital Deficiency (1996) (44)
- Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women. (1997) (43)
- Structure-based Inhibitor Design for an Enzyme That Binds Different Steroids (2007) (43)
- Androgens and breast cancer. (1992) (43)
- Effect of an LHRH agonist and hCG on testicular steroidogenesis in the adult rat. (1980) (43)
- Full oestrogenic activity of C19-Δ 5 adrenal steroids in rat pituitary lactotrophs and somatotrophs (1988) (43)
- Increased body fat mass explains the positive association between circulating estradiol and insulin resistance in postmenopausal women. (2018) (43)
- Dehydroepiandrosterone, androgens and the mammary gland (2006) (42)
- Purification of Microsomal and Mitochondrial 3β‐Hydroxysteroid Dehydrogenase/Δ5‐Δ4 Isomerase from Human Placenta (1990) (42)
- Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat (1998) (42)
- Serum androgen profile and physical performance in women Olympic athletes (2017) (42)
- Effects of sex steroids on regulation of the levels of C1 peptide of rat prostatic steroid-binding protein mRNA evaluated by in-situ hybridization. (1988) (42)
- Screening and early hormonal treatment of prostate cancer are accumulating strong evidence and support (2000) (42)
- Interactions between CRF, epinephrine, vasopressin and glucocorticoids in the control of ACTH secretion. (1984) (42)
- A study of LH-RH receptors in the pituitary gland of the winter flounder (Pseudopleuronectes americanus Walbaum). (1988) (42)
- Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line. (2010) (42)
- Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LH-RH in vitro (1974) (41)
- Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. (2004) (41)
- Lack of influence of dyspareunia on the beneficial effect of intravaginal prasterone (dehydroepiandrosterone, DHEA) on sexual dysfunction in postmenopausal women. (2014) (41)
- Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause (2015) (41)
- High bioavailability of dehydroepiandrosterone administered percutaneously in the rat. (1996) (41)
- Androstane-3α,17β-diol glucuronide as a steroid correlate of visceral obesity in men (1997) (41)
- Gender differences and effects of sex steroids and dehydroepiandrosterone on androgen and oestrogen α receptors in mouse sebaceous glands (2006) (41)
- Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells (1994) (41)
- New concepts on the androgen sensitivity of prostate cancer. (1987) (41)
- Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues. (1992) (41)
- Stimulation by prostaglandin F2 alpha of phosphatidic acid-phosphatidylinositol turnover in rat luteal cells. (1983) (41)
- Effects of flutamide and aminoglutethimide on plasma 5 alpha-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate. (1987) (40)
- Gonadal sex steroid status and bone health in middle-aged and elderly European men (2010) (40)
- Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-α-melanocyte-stimulating hormone (1975) (40)
- Role of sex steroids on LH and FSH secretion in the rat. (1976) (40)
- Distribution of radioactivity in the organs of the rat and mouse after injection of (125I)alpha-melanocyte-stimulating hormone. (1975) (40)
- Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. (1994) (40)
- Endocrine therapy for prostate cancer. (1991) (40)
- Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men. (2010) (40)
- Effect of intravaginal dehydroepiandrosterone (DHEA) on the female sexual function in postmenopausal women: ERC-230 open-label study (2016) (39)
- Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women (2007) (39)
- Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts. (1998) (39)
- Interleukin‐6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin‐1α on apolipoprotein D and GCDFP‐15 expression in human breast cancer cells (1995) (39)
- Sex steroids interact with dopamine at the hypothalamic and pituitary levels to modulate prolactin secretion. (1980) (39)
- Beta-adrenergic receptors in the rat mammary gland during pregnancy and lactation: characterization, distribution, and coupling to adenylate cyclase. (1990) (39)
- New hormonal therapy in prostate cancer: combined use of a pure antiandrogen and an LHRH agonist. (1983) (39)
- Occurrence of cytochrome P450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract (1995) (39)
- Androgenic down-regulation of urotensin II precursor, urotensin II-related peptide precursor and androgen receptor mRNA in the mouse spinal cord (2005) (39)
- Calcium‐dependent stimulation of prolactin release in rat anterior pituitaryin vitro by n6‐monobutyryl adenosine 3′,5′‐monophosphate (1972) (39)
- Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer (2007) (39)
- Immunoelectron microscopic localization of corticotropin-releasing factor in the rat hypothalamus. (1982) (39)
- Role of cyclic AMP in the action of hypothalamic regulatory hormones. (1975) (39)
- Effect of gonadal steroids on the luteinizing hormone and follicle-stimulating hormone response to 8-bromo-adenosine 3',5'-monophosphate in anterior pituitary cells in culture. (1978) (39)
- Effect of pharmacological blockade of ACTH and TSH secretion on the acute stimulation of prolactin release by exposure to cold and ether stress. (1976) (39)
- Genetic variations in sex steroid-related genes as predictors of serum estrogen levels in men. (2009) (38)
- Isolation, structural elucidation and synthesis of a tetradecapeptide with in vitro ACTH-releasing activity corresponding to residues 33-46 of the alpha-chain of porcine hemoglobin. (1978) (38)
- Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. (2003) (38)
- Electron microscope immunohistochemical localization of neurophysin in the rat hypothalamus and pituitary (1974) (38)
- Dissociated changes of pituitary luteinizing hormone-releasing hormone (LHRH) receptors and responsiveness to the neurohormone induced by 17 beta-estradiol and LHRH in vivo in the rat. (1981) (38)
- Characteristics of flutamide action on prostatic and testicular functions in the rat. (1988) (38)
- Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21. (1993) (38)
- Electron microscopic autoradiographic localization of prolactin mRNA in rat pituitary. (1989) (38)
- Organ distribution of radioactivity and disappearance of radioactivity from plasma after administration of (3H) luteinizing hormone-releasing hormone to mice and rats. (1974) (38)
- Relative importance of the adenohypophyseal and gonadal sites in inhibitory action of LHRH agonists. (1981) (38)
- Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland. (1998) (38)
- Cyclic adenosine 3',5'-monophosphate dependent phosphorylation of ribosomal proteins from bovine anterior pituitary gland. (1973) (37)
- Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA (2008) (37)
- Androgens in the maternal and fetal circulation: association with insulin resistance (2013) (37)
- Specific progesterone receptors in dimethylbenzanthracene (DMBA)-induced mammary tumors (1976) (37)
- Prostate specific antigen and prostatic acid phosphatase for monitoring therapy of carcinoma of the prostate. (1991) (37)
- Comparison of the effects of EM‐652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW‐5638 and raloxifene on the growth of human ZR‐75‐1 breast tumors in nude mice (2002) (36)
- Detection of a novel mutation (stop 468) in exon 10 of the low-density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians. (1994) (36)
- Potent stimulatory effect of interleukin‐1α on apolipoprotein D and gross cystic disease fluid protein‐15 expression in human breast‐cancer cells (1994) (36)
- Inhibitory effect of androgen on estrogen-induced prolactin messenger ribonucleic acid accumulation in the male rat anterior pituitary gland. (1989) (36)
- Comparison of intravaginal 6.5mg (0.50%) prasterone, 0.3mg conjugated estrogens and 10μg estradiol on symptoms of vulvovaginal atrophy (2017) (36)
- Pangenomic changes induced by DHEA in the skin of postmenopausal women (2008) (36)
- Adenosine 3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. II. Subcellular distribution. (1971) (36)
- Estrogen receptor α-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene (2005) (36)
- Regulation of growth hormone mRNA and pro-opiomelanocortin mRNA levels by cyclic AMP in rat anterior pituitary cells in culture. (1986) (36)
- Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG) (2006) (35)
- Receptor for thyrotropin-releasing hormone in plasma membranes of bovine anterior pituitary gland. Role of lipids. (1973) (35)
- Multiple steroid metabolic pathways in ZR-75-1 human breast cancer cells (1991) (35)
- Differential expression and regulation of connexin-43 and cell-cell coupling in myocytes from the circular and longitudinal layers of bovine myometrium. (1995) (35)
- Additive inhibitory effects of treatment with an LHRH agonist and an antiandrogen on androgen-dependent issues in the rat (1981) (35)
- High internal consistency and efficacy of intravaginal DHEA for vaginal atrophy (2010) (35)
- Androstenedione and androst-5-ene-3β,17β-diol stimulate DMBA-induced rat mammary tumors — role of aromatase (2005) (35)
- Combined long‐term treatment with an LHRH agonist and a pure antiandrogen blocks androgenic influence in the rat (1982) (35)
- Morphological Changes Induced by 6-Month Treatment of Intact and Ovariectomized Mice with Tamoxifen and the Pure Antiestrogen EM-800. (1997) (35)
- Sensitivity of pituitary and corpus luteum responses to single intranasal administration of (D-ser[TBU]6-des-gly-NH2(10)) luteinizing hormone-releasing hormone ethylamide (Buserelin) in normal women. (1982) (35)
- Serum estradiol is associated with lean mass in elderly Swedish men. (2010) (35)
- Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3 beta-hydroxysteroid dehydrogenase gene. (1995) (35)
- Localization and glucocorticoid regulation of 11β-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain (2007) (35)
- Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer. (2004) (35)
- Combined data of intravaginal prasterone against vulvovaginal atrophy of menopause (2017) (35)
- Validated LC–MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum (2015) (35)
- Interactions between LHRH, sex steroids and inhibin in the control of LH and FSH secretion (1978) (34)
- Prolactin and prolactinomas. (1983) (34)
- Stimulatory effect of synthetic progestins currently used for the treatment of prostate cancer on growth of the androgen-sensitive Shionogi tumor in mice. (1988) (34)
- Transrectal ultrasound evaluation of local prostate cancer in patients treated with LHRH agonist and in combination with flutamide. (1992) (34)
- Purification of adenohypophyseal plasma membranes and properties of associated adenylate cyclase. (1974) (34)
- Effect of twenty-four-week treatment with the antiestrogen EM-800 on estrogen-sensitive parameters in intact and ovariectomized mice. (1998) (34)
- Stimulation of phosphatidic acid and phosphatidylinositol labeling in luteal cells by luteinizing hormone releasing hormone. (1983) (34)
- Immunohistochemical localization of β-LPH in the human hypothalamus (1978) (33)
- Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate (1990) (33)
- The combination of a novel selective estrogen receptor modulator with an estrogen protects the mammary gland and uterus in a rodent model: the future of postmenopausal women's health? (2003) (33)
- Normal gonadal functions and fertility after 23 months of treatment of prepubertal male and female dogs with the GnRh agonist [D-Trp6, des-Gly-NH2(10)]GnRH ethylamide. (1989) (33)
- Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. (2009) (33)
- The Effects of MSH and MIF on the Brain (1975) (33)
- Efficacy of sequential cyclical hormonal therapy in endometrial cancer and its correlation with steroid hormone receptor status (1988) (33)
- Specific inhibition by glucocorticoids of the alpha 2-adrenergic stimulation of adrenocorticotropin release in rat anterior pituitary cells. (1982) (33)
- RHEUMATIC FEVER IN CHILDREN AND ADOLESCENTS. (1964) (33)
- Rapid modulation of ovarian 3β-hydroxysteroid dehydrogenase/Δ 5-Δ 4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat (1994) (33)
- Combined Effects of Dehydroepiandrosterone and EM-800 on Bone Mass, Serum Lipids, and the Development of Dimethylbenz(A)Anthracene-Induced Mammary Carcinoma in the Rat. (1997) (33)
- Decreased efficacy of twice-weekly intravaginal dehydroepiandrosterone on vulvovaginal atrophy (2015) (33)
- Antiestrogenic properties of keoxifene,trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells (1989) (33)
- Identification of three mutations in the low‐density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians (1998) (33)
- Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens. (1998) (32)
- Modulation of pituitary luteinizing hormone releasing hormone receptors by sex steroids and luteinizing hormone releasing hormone in the rat. (1982) (32)
- Strategies for chemoprevention of prostate cancer (1999) (32)
- A rapid and sensitive UPLC–MS/MS method for the simultaneous quantification of serum androsterone glucuronide, etiocholanolone glucuronide, and androstan-3α, 17β diol 17-glucuronide in postmenopausal women (2015) (32)
- Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. (1997) (32)
- Keoxifene shows pure antiestrogenic activity in pituitary gonadotrophs (1985) (32)
- Inhibitory effect of the novel anti‐estrogen EM‐800 and medroxyprogesterone acetate on estrone‐stimulated growth of dimethylbenz[a]anthracene‐induced mammary carcinoma in rats (1997) (32)
- Biosynthesis and Degradation of Androgens in Human Prostatic Cancer Cell Lines (1990) (32)
- LOSS OF LUTEINIZING HORMONE BIOACTIVITY IN PATIENTS WITH PROSTATIC CANCER TREATED WITH AN LHRH AGONIST AND A PURE ANTIANDROGEN (1986) (32)
- Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase close to D1S514 and the centromeric D1Z5 locus (1995) (32)
- Characterization of beta-adrenergic receptors in dispersed rat testicular interstitial cells. (1987) (31)
- Effects of ovariectomy and dehydroepiandrosterone (DHEA) on vaginal wall thickness and innervation. (2012) (31)
- Intracrinology and menopause: the science describing the cell-specific intracellular formation of estrogens and androgens from DHEA and their strictly local action and inactivation in peripheral tissues (2019) (31)
- Ocular toxicity of Anandron in patients treated for prostatic cancer. (1986) (31)
- Distribution of corticotropin-releasing factor in ovine brain determined by radioimmunoassay (1983) (31)
- Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y). (2007) (31)
- Corrigendum to “Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women” [Journal of Steroid Biochemistry and Molecular Biology (2008) 178–194] (2008) (31)
- Localisation of 15-hydroxy prostaglandin dehydrogenase (PGDH) and steroidogenic enzymes in the equine placenta. (1995) (31)
- Extensive esterification of adrenal C19-delta 5-sex steroids to long-chain fatty acids in the ZR-75-1 human breast cancer cell line. (1989) (31)
- Morphological study of the effects of an GnRH agonist on the canine testis after 4 months of treatment and recovery. (1987) (31)
- A common ancestor for mammalian 3 beta-hydroxysteroid dehydrogenase and plant dihydroflavonol reductase. (1990) (31)
- Synthesis and antiestrogenic activity of diaryl thioether derivatives. (1994) (30)
- Effect of estradiol and haloperidol on hypophysectomized rat brain dopamine receptors (1984) (30)
- Identification and characterization of the G15D mutation found in a male patient with 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) deficiency: alteration of the putative NAD-binding domain of type II 3 beta-HSD. (1995) (30)
- Intracrinology in action: Importance of extragonadal sex steroid biosynthesis and inactivation in peripheral tissues in both women and men (2015) (30)
- Site of calcium requirement for stimulation of ACTH release in rat anterior pituitary cells in culture by synthetic ovine corticotropin-releasing factor. (1982) (30)
- Effect of luteinizing hormone releasing hormone (LHRH) and [D-Trp6, DES-GLy-NH210] LHRH ethylamide on α-subunit and LHβ messenger ribonucleic acid levels in rat anterior pituitary cells in culture (1988) (29)
- Interaction between estradiol, prolactin, and striatal dopaminergic mechanisms. (1984) (29)
- Expression of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) and 17B-hydroxysteroid dehydrogenase (17β-HSD) in adipose tissue (1991) (29)
- Inhibition of ovulation during discontinuous intranasal luteinizing hormone-releasing hormone agonist dosing in combination with gestagen-induced bleeding. (1985) (29)
- Modulation by sex steroids and [D-Trp6, Des-Gly-NH2(10)]luteinizing hormone (LH)-releasing hormone ethylamide of alpha-subunit and LH beta messenger ribonucleic acid levels in the rat anterior pituitary gland. (1988) (29)
- Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues. (2004) (29)
- Persistence of high-grade prostatic intra-epithelial neoplasia under combined androgen blockade therapy. (1999) (29)
- Thyrotropin‐releasing hormone receptor: Its partial purification from bovine anterior pituitary gland and its close association with adenyl cyclase (1972) (29)
- Expression of Enzymes Involved in Estrogen Metabolism in Human Prostate (2006) (29)
- Antidopaminergic activity of estrogens on prolactin release at the pituitary level in vivo (1979) (29)
- Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone receptor expression in human breast cancer. (1989) (29)
- Additive inhibitory effects of bromocryptine (CB-154) and medroxyprogesterone acetate (MPA) on dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the rat. (1989) (29)
- Dinucleotide repeat polymorphisms in the HSD3B2 gene. (1994) (29)
- Atrial natriuretic factor-induced cGMP accumulation in rat anterior pituitary cells in culture is not coupled to hormonal secretion (1986) (29)
- Changes of pituitary sensitivity to LH-RH during the rat estrous cycle (1975) (29)
- Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line (2009) (29)
- Localization of 17 beta-hydroxysteroid dehydrogenase throughout gestation in human placenta. (1991) (28)
- Possible role of somatostatin in the regulation of the sexually differentiated steroid metabolism and prolactin receptor in rat liver. (1983) (28)
- Distribution of luteinizing hormone-releasing hormone receptors in the rat ovary (1982) (28)
- Downstaging by combination therapy with flutamide and an LHRH agonist before radical prostatectomy. (1995) (28)
- Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400448-JLR200 (2005) (28)
- Human 17β-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization (1994) (28)
- EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. (1998) (28)
- Specificity of the β2-adrenergic receptor stimulating cyclic AMP accumulation in the intermediate lobe of rat pituitary gland (1982) (28)
- Complete response to combination therapy with an LHRH agonist and flutamide in metastatic male breast cancer: a case report. (1990) (28)
- High inhibitory activity of R 5020, a pure progestin, at the hypothalamic-adenohypophyseal level on gonadotropin secretion. (1977) (28)
- GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer. (2014) (28)
- The development of the hypothalamo-pituitary axis in the neonatal rat: sexual maturation in male and female rats as assessed by hypothalamic LHRH and pituitary and serum LH and FSH concentrations. (1977) (28)
- Contents Vol. 54, 2000 (2001) (28)
- LHRH Agonists and Antiandrogens in Prostate Cancer (1987) (28)
- Prostatic Intraepithelial Neoplasia and Endocrine Manipulation (1999) (28)
- Inhibitory effect of androgens on DMBA-induced mammary carcinoma in the rat (1989) (28)
- Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium (2003) (28)
- Modulation of prolactin secretion by sex steroids and thyroid hormones (1980) (28)
- Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin. (1992) (28)
- The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. (2008) (28)
- Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells (2003) (27)
- Medical castration with LHRH agonists: 25 years later with major benefits achieved on survival in prostate cancer. (2004) (27)
- High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors. (1977) (27)
- Parallel release of ACTH, β-endorphdm, α-MSH and β-MSH-like immunoreactivities in rat anterior pituitary cells in culture (1979) (27)
- Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program. (2012) (27)
- Ontogenesis of 3β-Hydroxysteroid DehydrogenaseΔ5-Δ4 Isomerase in the Rat Adrenal as Revealed by Immunocytochemistry and in Situ Hybridization (1991) (27)
- Plasma levels of hydroxy‐flutamide in patients with prostatic cancer receiving the combined hormonal therapy: An LHRH agonist and flutamide (1988) (27)
- Immunohistochemical localization of 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5----delta 4 isomerase in human placenta and fetal membranes throughout gestation. (1992) (27)
- Prolactin and estradiol increase striatal dopamine receptor density in intact, castrated and hypophysectomized rats (1982) (27)
- Prevention of development of dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in the rat by the new nonsteroidal antiestrogen EM-800 (SCH57050) (1998) (27)
- Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal and gonadal specificity. (1991) (27)
- Rapid restriction fragment analysis for screening four point mutations of the Low‐density lipoprotein receptor gene in French Canadians (1995) (27)
- Anti-hormone treatment for prostate cancer relapsing after treatment with flutamide and castration. Addition of aminoglutethimide and low dose hydrocortisone to combination therapy. (1989) (27)
- N-butyl, N-methyl, 11-[3′,17′ β-(dihydroxy)-1′,3′,5′(10′)- estratrien-16′ α-yl]-9(R/S)-bromo undecanamide: synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities (1994) (27)
- Effects of human chorionic gonadotropin (hCG) and prolactin (PRL) on 3β-hydroxy-5-ene-steroid dehydrogenase/Δ 5-Δ 4 isomerase (3β-HSD) expression and activity in the rat ovary (1990) (26)
- Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity. (1995) (26)
- Inhibition of luteinizing hormone release by analogs of luteinizing hormone-releasing hormone (LHRH) in vitro. (1976) (26)
- Serum levels of sex steroids and metabolites following 12 weeks of intravaginal 0.50% DHEA administration (2015) (26)
- Castration levels of plasma testosterone have potent stimulatory effects on androgen-sensitive parameters in the rat prostate. (1988) (26)
- Increase in plasma ACTH after dopaminergic stimulation in rats (2004) (26)
- Inhibition of HCG-induced cyclic AMP accumulation and steroidogenesis in rat luteal cells by an LHRH agonist. (1981) (26)
- Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P450(C17)in ovine placentomes with the natural onset of labour. (2000) (26)
- Endocrine therapy of prostate cancer: optimal form and timing. (1995) (26)
- Purification, Cloning, Complementary DNA Structure, and Predicted Amino Acid Sequence of Human Estradiol 17β‐Dehydrogenase (1990) (26)
- Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. (1995) (26)
- Gonadotroph and corpus luteum responses to two successive intranasal doses of a luteinizing hormone-releasing hormone agonist at different days after the midcycle luteinizing hormone surge. (1983) (26)
- Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men (2011) (26)
- Relative potencies of Flutamide and Casodex: preclinical studies (1996) (26)
- Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS). (2011) (26)
- Cycling activity of benign prostatic epithelial cells during long‐term androgen blockade: evidence for self‐renewal of luminal cells (1998) (26)
- Site of the in vivo stimulatory effect of prostaglandins on LH release. (1976) (25)
- EFFECT OF THYROXINE ON THE INACTIVATION OF THYROTROPHIN‐RELEASING HORMONE BY RAT AND HUMAN PLASMA (1976) (25)
- Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey (2007) (25)
- Inhibitory effects of treatment with LHRH or its agonists on ovarian receptor levels and function. (1979) (25)
- Comparison of the Effects of the New Orally Active Antiestrogen EM-800 with ICI 182 780 and Toremifene on Estrogen-Sensitive Parameters in the Ovariectomized Mouse. (1998) (25)
- Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or β-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome (2015) (25)
- Combined effects of dehydroepiandrosterone and EM-800 on bone mass, serum lipids, and the development of dimethylbenz(A)anthracene-induced mammary carcinoma in the rat. (1997) (25)
- Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study. (2010) (25)
- Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus. (2007) (25)
- Ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) in human testis as studied by immunocytochemistry. (1991) (25)
- Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. (2001) (25)
- SELECTIVE INHIBITORY EFFECT OF PORCINE FOLLICULAR FLUID ON FOLLICLE STIMULATING HORMONE SECRETION IN ANTERIOR PITUITARY CELLS IN CULTURE (1979) (24)
- Interactions between Estrogens, Androgens, Progestins, and Glucocorticoids in ZR‐75‐1 Human Breast Cancer Cells (1990) (24)
- Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study (2011) (24)
- Is vulvovaginal atrophy due to a lack of both estrogens and androgens? (2017) (24)
- Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ5 — Δ4 isomerase (3β-HSD) in rat testis as studied by immunocytochemistry (1993) (24)
- Biphasic effect of estradiol and domperidone on lingual dyskinesia in monkeys (1983) (24)
- High risk genes predisposing to prostate cancer development—do they exist? (2000) (24)
- Serum steroids remain within the same normal postmenopausal values during 12-month intravaginal 0.50% DHEA (2015) (24)
- Dexamethasone is a potent stimulator of growth hormone-releasing factor-induced cyclic AMP accumulation in the adenohypophysis. (1984) (24)
- Localization of Type 8 17β-hydroxysteroid Dehydrogenase mRNA in Mouse Tissues as Studied by In Situ Hybridization (2005) (24)
- Steroid metabolism and profile of steroidogenic gene expression in Episkin™: High similarity with human epidermis (2007) (24)
- Structure-function relationships and molecular genetics of the 3β-hydroxysteroid dehydrogenase gene family (1995) (24)
- Skin responses to topical dehydroepiandrosterone: implications in antiageing treatment? (2010) (24)
- Ontogeny of prolactin mRNA in the rat pituitary gland as evaluated by in situ hybridization (1989) (24)
- Unconjugated and Glucuronide Steroid Levels in Human Breast Cyst Fluid (1990) (24)
- Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity. (1997) (23)
- Endocrine effects of combined treatment with an LHRH agonist in association with flutamide in metastatic prostatic carcinoma. (1988) (23)
- Characteristics of the β-adrenergic receptor in the rat ventral prostate using [125I]cyanopindolol (1986) (23)
- Actinomycin-sensitive induction of tyrosine transaminase and tryptophan pyrrolase by amino acids and tryptophan. (1968) (23)
- Development of androgen resistance in mouse mammary tumor cells can be prevented by the antiandrogen flutamide (1987) (23)
- Multihormonal regulation of dehydroepiandrosterone sulfotransferase messenger ribonucleic acid levels in adult rat liver. (1994) (23)
- Regulation of 3-ketosteroid reductase messenger ribonucleic acid levels and 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase activity in rat liver by sex steroids and pituitary hormones. (1992) (23)
- Advantages of the combination therapy in previously untreated and treated patients with advanced prostate cancer. (1986) (23)
- Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. (2008) (23)
- Gonadotropins and estradiol responses to single intranasal or subcutaneous administration of a luteinizing hormone-releasing hormone agonist in the early follicular phase. (1983) (23)
- Characteristics of action of prostaglandins on cyclic AMP accumulation in rat anterior pituitary gland. (1975) (23)
- Serum luteinizing hormone (LH) biological activity in castrated patients with cancer of the prostate receiving a pure antiandrogen and in estrogen-pretreated patients treated with an LH-releasing hormone agonist and antiandrogen. (1986) (23)
- Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report. (1992) (23)
- Pure selective estrogen receptor modulators, new molecules having absolute cell specificity ranging from pure antiestrogenic to complete estrogen-like activities. (2001) (22)
- N-Butyl-N-methyl-11-(3'-hydroxy-21',17'-carbolactone-19'-nor-17'α-pregna-1',3',5'(10')-trien-7'α-yl)-undecanamide: an inhibitor of type 2 17β-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity (2000) (22)
- Comparison of crystal structures of human type 3 3α‐hydroxysteroid dehydrogenase reveals an “induced‐fit” mechanism and a conserved basic motif involved in the binding of androgen (2005) (22)
- Characterization of two mRNA species encoding human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17. (1989) (22)
- Immunohistochemical localization of 3 beta-hydroxysteroid/delta 5-delta 4-isomerase, tyrosine hydroxylase and phenylethanolamine N-methyl transferase in adrenal glands of sheep fetuses throughout gestation and in neonates. (1992) (22)
- Expression of 17β-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: A correlation to clinicopathological parameters (2008) (22)
- Characterization, expression, and immunohistochemical localization of 5 alpha-reductase in human skin. (1994) (22)
- Impairment of pituitary and gonadal functions in alloxan-induced diabetic male rats (1980) (22)
- Ontogenesis of 3 beta-hydroxysteroid dehydrogenase delta 5-delta 4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization. (1993) (22)
- Genetic linkage mapping of the human steroid 5 alpha-reductase type 2 gene (SRD5A2) close to D2S352 on chromosome region 2p23-->p22. (1996) (22)
- Characteristics of the plasma disappearance of (3H)-thyrotropin-releasing hormone in the rat. (1974) (22)
- Radioautographic localization of radioactivity in rat brain after intraventricular or intracarotid injection of 3H-L-prolyl-L-leucyl glycinamide (1975) (22)
- Outcome of Vaginoplasty in Male-to-Female Transgenders: A Systematic Review of Surgical Techniques (2015) (22)
- Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone. (1996) (22)
- Testosterone and depressive symptoms among men in the Diabetes Prevention Program (2016) (22)
- Long‐term inhibitory effects of a novel anti‐estrogen on the growth of ZR‐75‐1 and MCF‐7 human breast cancer tumors in nude mice (1997) (22)
- Androgenic action of dehydroepiandrosterone (DHEA) on nerve density in the ovariectomized rat vagina. (2013) (22)
- Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3β-hydroxysteroid dehydrogenase/5→4-ene-isomerase activity (1990) (22)
- Almost Exclusive Androgenic Action of Dehydroepiandrosterone in the Rat Mammary Gland. (1998) (21)
- Stimulated release of hypothalamic growth hormone-releasing activity by morphine and pentobarbital (1977) (21)
- Morphological Studies of Prolactin-Secreting Cells in Estrogen Receptor α and Estrogen Receptor β Knockout Mice (2003) (21)
- Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat mammary tumors (1988) (21)
- Why both LC–MS/MS and FDA-compliant validation are essential for accurate estrogen assays? (2015) (21)
- Stimulation of Androgen‐Dependent Gene Expression by the Adrenal Precursors Dehydroepiandrosterone and Androstenedione in the Rat Ventral Prostate (1990) (21)
- Inhibition by six somatostatin analogs of plasma growth hormone levels stimulated by thiamylal and morphine in the rat (1976) (21)
- Evaluation of AIbZIP and Cdc47 as markers for human prostatic diseases. (2007) (21)
- Immunocytochemical localization of 5 alpha-reductase in rat brain. (1994) (21)
- Calcium requirement for stimulation of cyclic AMP accumulation in anterior pituitary gland by LH-RH (1975) (21)
- Androgenic 17β-hydroxysteroid dehydrogenase activity of expressed rat type I 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (1992) (21)
- Stability of secretory granules containing growth hormone and prolactin from bovine anterior pituitary gland. (1974) (21)
- Presence of C-19 steroids in mammary Shionogi carcinoma (SC 115) in castrated mice. (1985) (21)
- Adrenal C19-5-ene steroids induce full estrogenic responses in rat pituitary gonadotrophs. (1987) (21)
- Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in previously untreated patients with clinical stage D2 prostate cancer: today's therapy of choice. (1988) (21)
- Codon 367 polymorphism of the human type I 3 beta-hydroxysteroid dehydrogenase/isomerase gene (HS5DB3). (1991) (21)
- Linkage analysis of 26 Canadian breast and breast-ovarian cancer families (1995) (21)
- Somatostatin prevents the desensitizing action of growth hormone-releasing factor on growth hormone release (1987) (20)
- RAPID INACTIVATION OF ENKEPHALIN-LIKE MATERIAL BY C.S.F. IN CHRONIC SCHIZOPHRENIA (1978) (20)
- Adenosine-3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. 3. Structural specificity of the ATP site of the catalytic subunit. (1974) (20)
- Characteristics of the β‐adrenergic stimulation of adenylate cyclase activity in rat ventral prostate and its modulation by androgens (1986) (20)
- Combined blockade of testicular and locally made androgens in prostate cancer: A highly significant medical progress based upon intracrinology (2015) (20)
- Effect of Dehydroepiandrosterone on Bone Mass, Serum Lipids, and Dimethylbenz(a)anthracene-Induced Mammary Carcinoma in the Rat. (1997) (20)
- Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. (1977) (20)
- Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. (2014) (20)
- Study of the direct action of luteinizing hormone-releasing hormone agonists at the testicular level in intact rats treated with an antiluteinizing hormone serum. (1982) (20)
- Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. (1992) (20)
- Gender differences in hemodynamic responses to endothelin-1. (2000) (20)
- Multiple hormonal control of pars intermedia cell activity. (1983) (20)
- Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. (2007) (20)
- Controversies : Endocrine therapy of prostate cancer : optimal form and appropriate timing (1995) (20)
- Combination of screening and preoperative endocrine therapy: the potential for an important decrease in prostate cancer mortality. (1995) (20)
- Steroid derivatives as pure antagonists of the androgen receptor (2012) (19)
- Mediation by the androgen receptor of the stimulatory and antiandrogenic actions of 17 beta-estradiol on the growth of androgen-sensitive Shionogi mammary carcinoma cells in culture. (1988) (19)
- Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: Antagonism by insulin (1989) (19)
- Androgen blockade in prostate cancer in 2002: major benefits on survival in localized disease (2002) (19)
- Synthesis of 17β-estradiol derivatives with n-butyl, n-methyl alkylamide side chain at position 15 (1991) (19)
- Combination therapy with flutamide and the LHRH agonist [D-Trp6, des-Gly-NH(2)10]LHRH ethylamide in stage C prostatic carcinoma. (1993) (19)
- Combination of an antiandrogen and a 5 alpha-reductase inhibitor: a further step towards total androgen blockade? (1991) (19)
- Radioautographic Localization of β‐Adrenergic Receptors in the Rat Ventral Prostate (1986) (19)
- MULTIPLE FACTORS INVOLVED IN THE CONTROL OF ACTH AND α-MSH SECRETION (1983) (19)
- Glycosyltransferase and UDP-galactose pyrophosphatase activities in the endometrium during oestrous cycle of the rat. (1977) (19)
- A low dose (6.5 mg) of intravaginal DHEA permits a strictly local action while maintaining all serum estrogens or androgens as well as their metabolites within normal values (2017) (19)
- Distribution of radioactivity in the organs of the rat and mouse after injection of L-(3H)prolyl-L-leucyl-glycinamide. (1975) (19)
- Combination therapy with flutamide and medical (LHRH agonist) or surgical castration in advanced prostate cancer: 7-year clinical experience (1990) (19)
- The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams (2017) (19)
- Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes. (1990) (19)
- Bioavailability and pharmacokinetics of dehydroepiandrosterone in the cynomolgus monkey. (2003) (19)
- Induction of rat liver tyrosine aminotransferase by dibutyryl cyclic AMP and its inhibition by actinomycin D and α‐Amanitin (1971) (18)
- Sex-related Expression of 20α-hydroxysteroid Dehydrogenase mRNA in the Adult Mouse (2003) (18)
- The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer: a review. (1984) (18)
- Plasma 3 beta-hydroxy-delta 5-steroids in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. (1994) (18)
- A Novel Pure SERM Achieves Complete Regression of the Majority of Human Breast Cancer Tumors in Nude Mice (2003) (18)
- Synthesis and in vitro activity of 17 beta-(N-alkyl/arylformamido)- and 17 beta-[(N-alkyl/aryl)alkyl/arylamido]-4-methyl-4-aza-3-oxo-5 alpha-androstan-3-ones as inhibitors of human 5 alpha-reductases and antagonists of the androgen receptor. (1995) (18)
- Isolation and characterization of a cDNA encoding mouse 3α-hydroxysteroid dehydrogenase An androgen-inactivating enzyme selectively expressed in female tissues (2006) (18)
- ["Intracrinology". Autonomy and freedom of peripheral tissues]. (1995) (18)
- Reductions in glucose among postmenopausal women who use and do not use estrogen therapy (2012) (18)
- Comparison of the effects of the new orally active antiestrogen EM-800 with ICI 182 780 and toremifene on estrogen-sensitive parameters in the ovariectomized mouse. (1998) (18)
- Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines]. (1983) (18)
- Effect of dehydroepiandrosterone on bone mass, serum lipids, and dimethylbenz(a)anthracene-induced mammary carcinoma in the rat. (1997) (18)
- Weight loss decreases follicle stimulating hormone in overweight postmenopausal women (2015) (18)
- Major impact of hormonal therapy in localized prostate cancer—death can already be an exception (2004) (18)
- Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients. (1987) (17)
- Hormonal regulation of beta-adrenergic receptors in the rat mammary gland during the estrous cycle and lactation: role of sex steroids and prolactin. (1990) (17)
- Androstane-3alpha,17beta-diol glucuronide as a steroid correlate of visceral obesity in men. (1997) (17)
- Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids. (1996) (17)
- Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384 (1995) (17)
- Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase. (1996) (17)
- Recovery of gonadal functions in the adult male rat following cessation of five-month daily treatment with an LHRH agonist. (1984) (17)
- Synthesis and structure–activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution (2005) (17)
- Androstenedione and androst-5-ene-3 beta,17 beta-diol stimulate DMBA-induced rat mammary tumors--role of aromatase. (1989) (17)
- Mechanism of action of TRH: involvement of the phosphatidylinositol (PI) response in the action of TRH in rat anterior pituitary cells. (1982) (17)
- Binding of the opiate-like pentapeptide methionine-enkephalin to a particulate fraction from rat brain. (1976) (17)
- Stimulatory Effects of Androgens, Estrogens, Progestins, and Dexamethasone on the Growth of the LNCaP Human Prostate Cancer Cells (1990) (17)
- Multiple Factors Controlling ACTH Secretion at the Anterior Pituitary Level (1987) (17)
- Parallel stimulation of ACTH, β-LPH + β-endorphin and α-MSH release by α-adrenergic agents in rat anterior pituitary cells in culture (1981) (17)
- Response of the adipose tissue transcriptome to dihydrotestosterone in mice. (2008) (17)
- Androgen inhibition of basal and estrogen-stimulated prolactin binding in rat liver (1977) (17)
- Localization and regulation of expression of the FAR-17A gene in the hamster flank organs. (1996) (17)
- Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation (2008) (16)
- Adrenal steroids stimulate growth and progesterone receptor levels in rat uterus and DMBA-induced mammary tumors (2005) (16)
- DHEA as physiological replacement therapy at menopause (1998) (16)
- Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells (1990) (16)
- Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo (2009) (16)
- Effect of estrone on the growth of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in the rat: a model of postmenopausal breast cancer. (1994) (16)
- Androgen receptor and familial prostate cancer (1995) (16)
- Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol. (1996) (16)
- Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes. (2001) (16)
- Future perspectives of selective estrogen receptor modulators used alone and in combination with DHEA. (2006) (16)
- Beta-adrenergic receptors in DMBA-induced rat mammary tumors: Correlation with progesterone receptor and tumor growth (1989) (16)
- Modulation of rat pituitary gonadotrophin secretion by porcine granulosa cell 'inhibin', LH releasing hormone and sex steroids in rat anterior pituitary cells in culture. (1984) (16)
- Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey (2002) (16)
- Estradiol, TRH and striatal dopaminergic mechanisms (1982) (16)
- Characteristics of the inhibitory effect of chronic treatment with an LHRH agonist on testicular steroidogenesis in the dog (1984) (16)
- Influence of treatment of vulvovaginal atrophy with intravaginal prasterone on the male partner (2015) (15)
- Adrenal precursor C19 steroids are potent stimulators of growth of androgen-sensitive mouse mammary carcinoma Shionogi cells in vitro (1988) (15)
- Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism. (2003) (15)
- Screening and hormonal therapy of localized prostate cancer shows major benefits on survival. (2000) (15)
- Androgens in Gynecological Practice: Androgens in postmenopausal women: their practically exclusive intracrine formation and inactivation in peripheral tissues (2015) (15)
- Localization of type 7 17β-hydroxysteroid dehydrogenase in mouse tissues In situ hybridization studies (2005) (15)
- Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat (2008) (15)
- Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates. (2002) (15)
- Important prognostic value of standardized objective criteria of response in stage D2 prostatic carcinoma. (1988) (15)
- Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. (2006) (15)
- Sensitizing effect of treatment with estrogens on TSH response to TRH in male rats. (1977) (14)
- Androgen blockade in prostate cancer (2000) (14)
- Metastatic prostate cancer pulmonary nodules: Beneficial effects of combination therapy and subsequent withdrawal of flutamide (1994) (14)
- Glucocorticoids stimulate the growth of mouse mammary carcinoma Shionogi cells in culture (1988) (14)
- Combination therapy with flutamide and [D-Trp6]LHRH ethylamide for stage C prostatic carcinoma. (1988) (14)
- Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus (2006) (14)
- Prostate cancer pathology, screening, and epidemiology. (2001) (14)
- Expression of the estrogen receptors and steroidogenic enzymes involved in estradiol formation in the monkey vagina. (2014) (14)
- Effects of progestagen treatments and PMSG on the induction of the preovulatory LH discharge in ewes (1983) (14)
- Acute vascular effects of the selective estrogen receptor modulator EM-652 (SCH 57068) in the rat mesenteric vascular bed. (2003) (14)
- Differential effects of a steroidal antiestrogen, EM-139, on prostaglandin and cyclic adenosine 3',5'-monophosphate production in the circular and longitudinal layers of bovine myometrium. (1995) (14)
- Androgen receptor modulation in benign human prostatic tissue and prostatic adenocarcinoma during neoadjuvant endocrine combination therapy (1996) (14)
- Localization of type 5 17β-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization (2005) (14)
- Estrogen-stimulated glucuronidation of dihydrotestosterone in MCF-7 human breast cancer cells (1992) (14)
- Anterior Pituitary Cells in Culture: A Precise Assay System for Hypothalamic and Peripheral Hormones (1983) (14)
- Effects of the new generation selective estrogen receptor modulator EM-652 and oral administration of estradiol valerate on circulating, brain, and adrenal beta-endorphin and allopregnanolone levels in intact fertile and ovariectomized rats. (2002) (14)
- Reversible inhibition of testicular androgen secretion by 3-, 5- and 6-month controlled-release microsphere formulations of the LH-RH agonist [D-Trp6, des-Gly-NH10(2)] LH-RH ethylamide in the dog. (1989) (13)
- Anti-androgens in treatment of prostate cancer (1995) (13)
- Synthesis and in vitro evaluation of 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17 beta-carboxamides as 5 alpha-reductase inhibitors and antiandrogens. (1995) (13)
- Wide spectrum of steroids serving as substrates for the formation of lipoidal derivatives in ZR-75-1 human breast cancer cells. (1990) (13)
- Modulation of gonadotropin secretion by Sertoli cell inhibin, LHRH, and sex steroids. (1984) (13)
- 17α-Alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity (1999) (13)
- Microarray analysis of survival pathways in human PC-3 prostate cancer cells. (2007) (13)
- Further Studies on the Inhibitory Effect of [D‐A1a6, des‐Gly‐NH210]LHRH Ethylamide on Spermatogenesis and Steroidogenesis in the Rat: Reversibility and Effect of Androgen Administration (1980) (13)
- CRF stimulates adenylate cyclase activity in the intermediate lobe of the pituitary gland (1983) (13)
- Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears. (1996) (13)
- Interactions between hypothalamic and peripheral hormones in the control of prolactin secretion. (1980) (13)
- Expression of 11β-hydroxysteroid Dehydrogenase Type 1 in Breast Cancer and Adjacent Non-Malignant Tissue. An Immunocytochemical Study (2011) (13)
- Changes in 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase messenger ribonucleic acid, activity and protein levels during the estrous cycle in the bovine ovary. (1990) (13)
- Stimulatory effect of luteinizing hormone and human chorionic gonadotropin on testicular prolactin receptor levels. (1980) (13)
- Plasma lipoprotein profile in the male cynomolgus monkey under normal, hypogonadal, and combined androgen blockade conditions. (2004) (13)
- Cations inhibit specifically type I 5 alpha-reductase found in human skin. (1995) (13)
- Mild dementia is associated with increased adrenal secretion of cortisol and precursor sex steroids in women (2011) (13)
- D-Ring alkylamine derivatives of estradiol: effect on er-binding affinity and antiestrogenic activity (1996) (13)
- Steroid hormones—agonists and antagonists (1981) (13)
- Isolation and characterization of a stereospecific 3beta-hydroxysteriod sulfotransferase (pregnenolone sulfotransferase) cDNA. (1996) (13)
- Growth hormone inhibition of hydrocortisone induction of tyrosine transaminase and tryptophan pyrrolase and its reversal by amino acids. (1968) (13)
- Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin. (2000) (13)
- Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. (2004) (13)
- Combination therapy with castration and flutamide: today's treatment of choice for prostate cancer. (1989) (13)
- Cellular Localization of mRNA Expression of Enzymes Involved in the Formation and Inactivation of Hormonal Steroids in the Mouse Prostate (2004) (13)
- BEHAVIOURAL AND BIOCHEMICAL EVIDENCE OF AN EFFECT OF ESTRADIOL ON STRIATAL DOPAMINE RECEPTORS (1981) (13)
- Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry (2007) (13)
- Morphological changes induced by 6-month treatment of intact and ovariectomized mice with tamoxifen and the pure antiestrogen EM-800. (1997) (13)
- Regulation of Adrenal 3β-Hydroxysteroid Dehydrogenase/Δ5-δ4-Isomerase Expression and Activity by Adrenocorticotropin and Corticosterone in the Rat* (1991) (13)
- COMBINATION THERAPY IN PROSTATE CANCER (1986) (12)
- Transcriptome of mouse uterus by serial analysis of gene expression (SAGE): Comparison with skeletal muscle (2004) (12)
- Parellel inhibition of LH-RH-induced cyclic AMP accumulation and LH and FSH release by LH-RH antagonists in vitro. (1975) (12)
- New aspects of the control of pituitary hormone secretion. (1978) (12)
- Morphological studies of prolactin-secreting cells in estrogen receptor alpha and estrogen receptor beta knockout mice. (2003) (12)
- Inhibition of progesterone secretion during the luteal phase by two luteinizing hormone-releasing hormone agonists in Macaca fascicularis. (1980) (12)
- Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland (2012) (12)
- Expression of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) in adipose tissue. (1991) (12)
- Prolactin Stimulation of Testicular Steroid Biosynthesis in the Male Rat (1981) (12)
- Expression of Estrogen Sulfotransferase 1E1 and Steroid Sulfatase in Breast Cancer: A Immunohistochemical Study (2009) (12)
- Multiple intracrine hormonal targets in the prostate: opportunities and challenges (2007) (12)
- Expression of enzymes involved in synthesis and metabolism of estradiol in human breast as studied by immunocytochemistry and in situ hybridization. (2009) (12)
- Changes in the abundance of mRNA for type-I 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase in the human placenta and fetal membranes during pregnancy and labor. (1993) (12)
- 481 HIGH SERUM TESTOSTERONE IS ASSOCIATED WITH REDUCED RISK OF CARDIOVASCULAR EVENTS IN ELDERLY MEN (2011) (12)
- Proteomic analysis identifies new biomarkers for postmenopausal and dry skin (2012) (12)
- Synthesis and biological activity of 17α-alkynylamide derivatives of estradiol (1991) (12)
- Phosphorylation of nuclear proteins fron bovine anterior pituitary gland induced by adenosine 3':5'-monophosphate. (1974) (12)
- Prevalence of depression and anxiety in women newly diagnosed with vulvovaginal atrophy and dyspareunia. (2019) (12)
- Effects of colchicine on the morphology and prolactin secretion of rat anterior pituitary cells in monolayer culture. (1979) (12)
- Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells. (1992) (12)
- Octreotide and bromocriptine in patients with stage D2 prostate cancer who relapsed during treatment with flutamide and castration. (1990) (11)
- Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase (2010) (11)
- Dopaminergic activity of some simplified ergoline derivatives (1981) (11)
- Beta-adrenergic, CRF-ergic and dopaminergic mechanisms controlling α-MSH secretion in rat pars intermedia cells in primary culture (1982) (11)
- CRF stimulates alpha-MSH secretion and cyclic AMP accumulation in rat pars intermedia cells. (1982) (11)
- Stimulation of adenosine 3',5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by purified growth hormone-releasing hormone. (1973) (11)
- Potent inhibitory activity of a new antiestrogen, RU 16 117, on the development and growth of DMBA-induced rat mammary adenocarcinoma. (1976) (11)
- Major advantages of "early" administration of endocrine combination therapy in advanced prostate cancer. (1993) (11)
- Mechanism of action of luteinizing hormone releasing hormone and thyrotropin releasing hormone in the anterior pituitary gland and modulation of their activity by peripheral hormones. (1977) (11)
- Effects of estrogens on the ultrastructural characteristics of female rat prolactin cells as evaluated by in situ hybridization in combination with immunogold staining technique. (1990) (11)
- New aspects of the mechanism of action of hypothalamic regulatory hormones. (1976) (11)
- Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family (2007) (11)
- Structure, regulation and role of 3 beta-hydroxysteroid dehydrogenase, 17 beta-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues. (1994) (11)
- Effects of flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat. (1987) (11)
- Multiple factors involved in the control of ACTH secretion (1984) (11)
- The enzyme and inhibitors of 4-ene-3-oxosteroid 5 alpha-oxidoreductase. (1995) (11)
- Attempts to demonstrate peptide localization and secretion in primary cell cultures of fetal rat hypothalamus. (1981) (11)
- Immunoelectron microscopic localization of 3 (cid:1) -hydroxysteroid dehydrogenase and type 5 17 (cid:1) -hydroxysteroid dehydrogenase in the human prostate and mammary gland (2001) (11)
- Vinyl fluoride as a mimic of the "intermediate' enol form in the 5 alpha-reductase transformation: synthesis and in vitro activity of (N-1',1'-dimethylethyl)-3-haloandrost-3,5-diene-17 beta-carboxamides. (1996) (11)
- Highly efficient nucleophilic addition of alkyl Grignard reagents to 17-ketosteroids in the presence of cerium(III) chloride: Synthesis of 17α-propyl-17β-hydroxy-4-androsten-3-one, an androgen receptor antagonist (1994) (11)
- A pure antiandrogen does not interfere with the LHRH agonist-induced blockade of testicular androgen secretion in the dog (1988) (11)
- Relationship among initial serum prostate specific antigen, prostate specific antigen progression and prostate cancer detection at repeat screening visits. (2006) (11)
- Long‐term inhibitory effect of the orally active and pure antiestrogen EM‐800 on the growth of human breast cancer xenografts in nude mice (2000) (10)
- Rapid modulation of ovarian 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat. (1994) (10)
- RE: Is There a Correlation Between Androgens and Sexual Desire in Women? (2015) (10)
- Intracrinology: its impact on prostate cancer (1993) (10)
- Androgen receptor as a potential sign of prostate cancer metastasis (2009) (10)
- Crystal growth of human estrogenic 17beta-hydroxysteroid dehydrogenase. (1994) (10)
- Synthesis and deuterium labelling of the pure selective estrogen receptor modulator (SERM) acolbifene glucuronides (2007) (10)
- F099 metabolic effects of 12-month percutaneous DHEA replacement therapy in postmenopausal women (1996) (10)
- Blockade of androstenedione-induced stimulation of androgen-sensitive parameters in the rat prostate by combination of Flutamide and 4-MA (1993) (10)
- COMBINED TREATMENT WITH FLUTAMIDE AND SURGICAL OR MEDICAL (LHRH AGONIST) CASTRATION IN METASTATIC PROSTATIC CANCER (1986) (10)
- Effects of the antiestrogen EM-800 (SCH 57050) and cyclophosphamide alone and in combination on growth of human ZR-75-1 breast cancer xenografts in nude mice. (1999) (10)
- Characterization and measurement of prostate-specific antigen using monoclonal antibodies. (1993) (10)
- Effect of combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice. (1999) (10)
- Inhibitory effects of RU 16117, a potent estrogen antagonist, on the estrous cycle in the rat. (1978) (10)
- INHIBITORY ACTIVITY OF ANALOGUES OF LUTEINIZING HORMONE‐RELEASING HORMONE (LH‐RH) IN VITRO AND IN VIVO (1976) (10)
- 3β-Alkyl-androsterones as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines (2006) (10)
- Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization. (2004) (10)
- Androgens exert selective effects on protein kinase C induced LH and FSH release in rat anterior pituitary cells in culture. (1988) (10)
- Molecular Mechanism of Inhibition of Steroid Dehydrogenases by Licorice‐Derived Steroid Analogs in Modulation of Steroid Receptor Function a (1995) (10)
- 32 Cloned shionogi mouse mammary carcinoma cells develop a wide range of sensitivities as well as resistance to androgens (1985) (10)
- Letter to the Editor: Superior Mass Spectrometry-Based Estrogen Assays Should Replace Immunoassays. (2015) (10)
- Age-dependent changes in the beta-endorphin content of discrete rat brain nuclei. (1981) (10)
- Comparative study of central dopaminergic properties of RU 29717 (N-propyl-9-oxaergoline) and pergolide. (1983) (10)
- Controlled release low dose medroxyprogesterone acetate (MPA) inhibits the development of mammary tumors induced by dimethyl-benz(a) anthracene in the rat (2004) (9)
- Expression of human 17 beta-hydroxysteroid dehydrogenase in mammalian cells. (1992) (9)
- Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus (2009) (9)
- The pituitary dopamine receptor. (1980) (9)
- Antagonistic activity of analogs of luteinizing hormone-releasing hormone (LH-RH) in vitro (1976) (9)
- Sensitivity of rat adenohypophyseal cells to estradiol and LHRH during long-term culture. (1981) (9)
- Potent Antagonism between Estrogens and Androgens on GCDFP‐15 Expression and Cell Growth in the ZR‐75‐1 Human Breast Cancer Cells a (1990) (9)
- Effect of GnRH-induced endogenous luteinizing hormone release and exogenous progestogen treatment on ovarian activity in the postpartum ewe. (1982) (9)
- 1H and 13C nuclear magnetic resonance assignments and stereochemistry of N-n-butyl-N-methyl-11-(16′α-chloro-3′,17′β- and 17′ α-dihydroxyestrase-1′,3′,5′(10′)-trien-7′αyl undecanamide (1994) (9)
- The ESR1 (6q25) Locus Is Associated with Calcaneal Ultrasound Parameters and Radial Volumetric Bone Mineral Density in European Men (2011) (9)
- Opposite effects of prolactin and corticosterone on the expression and activity of 3β-hydroxysteroid dehydrogenase/δ5-δ4 isomerase in rat skin (1994) (9)
- Hormonal and biochemical changes during treatment of endometriosis with the luteinizing hormone-releasing hormone (LH-RH) agonist [D-Trp6,des-Gly-NH2(10)]LH-RH ethylamide. (1990) (9)
- Luteolytic activity of LHRH and [D-Ser(TBU)6, des-Gly-NH2(10)]LHRH ethylamide: a new and physiological approach to contraception in women. (1980) (9)
- Effect of glucagon, insulin, and thyroxine on tyrosine transaminase and tryptophan pyrrolase of rat liver. (1969) (9)
- Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients with advanced prostate cancer. (1988) (9)
- Autohistoradiographic localization of thyrotropin-releasing hormone (TRH)-binding sites in cultured rat pituitary cells. (1979) (9)
- Localization of Peptide Gene Expression by in Situ Hybridization at Electron Microscopic Level (1989) (9)
- Characteristics of the desensitization of growth hormone and cyclic AMP responses to growth hormone-releasing factor and prostaglandin E2 in rat anterior pituitary cells in culture (1986) (9)
- Antifertility effects of luteinizing hormone-releasing hormone (LHRH) agonists. (1981) (9)
- Androgen levels in prostatic tissue of patients with carcinoma of the prostate treated with the combined therapy using an LHRH agonist and a pure antiandrogen (1986) (9)
- Formation and degradation of dihydrotestosterone by recombinant members of the rat 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase family (1994) (9)
- Hormonal Regulation of Estradiol 17β‐Hydroxysteroid Dehydrogenase Activity in the ZR‐75‐1 Human Breast Cancer Cell Line (1990) (9)
- Human 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth. (2016) (9)
- Selective inhibition of spermatogenesis in the presence of normal libido following combined treatment with an LHRH agonist and testosterone in the dog. (1984) (8)
- Localization of BRCA1 Gene Expression in Adult Cynomolgus Monkey Tissues (1997) (8)
- THE PROLACTIN CELL: STRUCTURE AND FUNCTION (1984) (8)
- Sensitivity of luteinizing hormone and gonadal steroid responses to single intranasal administration of an LHRH agonist (Hoe-766) in young normal adult men (1982) (8)
- Estimated potency of casodex: A problematic design [1] (multiple letters) (1997) (8)
- Chemical synthesis and biological activities of 16α-derivatives of 5α-androstane-3α,17β-diol as antiandrogens (2007) (8)
- Prostate-specific genes and their regulation by dihydrotestosterone. (2008) (8)
- Role of Extra‐Ovarian Oestrogens in the Regulation of Gonadotropin Releasing Hormone mRNA Expression in the Rat Brain (2001) (8)
- Morphological studies of the canine pituitary luteinizing hormone (LH) cells after long-term treatment with the LH-releasing hormone (LHRH) agonist [D-Trp6]LHRH ethylamide. (1987) (8)
- Inhibitory effects of medroxyprogesterone acetate (MPA) and the pure antiestrogen EM-219 on estrone (E1)-stimulated growth of dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat (1995) (8)
- Molecular Biology of Steroid Sulfotransferases a (1996) (8)
- Evaluation of the acceptability of intravaginal prasterone ovule administration using an applicator (2016) (8)
- The importance of optimal extraction to insure the reliable MS-based assays of endogenous compounds. (2016) (8)
- Weight loss results in a small decrease in follicle stimulating hormone in overweight glucose-intolerant postmenopausal women (2014) (8)
- Inhibition of Spermatogenesis and Steroidogenesis During Long-Term Treatment with hCG in the Rat (1982) (8)
- Effect of a long-term percutaneous adrenal steroid treatment on rat adipose tissue metabolism (2000) (8)
- Effect of 3-week treatment with [D-Trp6, des-Gly-NH10(2)]LHRH ethylamide, aminoglutethimide, ketoconazole or flutamide alone or in combination on testicular, serum, adrenal and prostatic steroid levels in the dog. (1989) (8)
- Effects of progesterone and R2323 on the development of dimethylbenzanthracene-induced mammary tumors. (1979) (8)
- Enzymatic degradation of somatostatin by rat plasma and hypothalamus. (1978) (8)
- Variations of pre-prosomatostatin MRNA levels in the hypothalamic periventricular nucleus during the rat estrous cycle (1991) (8)
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- High Level of Esterification of Steroids to Long‐Chain Fatty Acids in ZR‐75‐1 Human Breast Cancer Cells (1990) (5)
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- Glycoprotein Hormones: Gonadotropins and Thyrotropin (1990) (5)
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- Inhibition of human-type 1 3β-hydroxysteroid deshydrogenase/Δ5-Δ4-isomerase expression using siRNA (2005) (4)
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- F116 Important androgenic component in the stimulatory effect of dehydroepiandrosterone (DHEA) on bone density in the rat (1996) (4)
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- Detection of frequent BglII polymorphism by polymerase chain reaction and TaqI restriction fragment length polymorphism for 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase at the human HSD beta 3 locus (1p11-p13). (1991) (2)
- N-butyl, N-methyl, 11-[3',17' beta-(dihydroxy)-1',3',5'(10')-estratrien-16' alpha-yl]-9(R/S)-bromo undecanamide: synthesis and 17 beta-HSD inhibiting, estrogenic and antiestrogenic activities. (1994) (2)
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- Luteinising Hormone-Releasing Hormone Agonists and Fertility Regulation the 9th Jennifer Hallam Memorial Lecture (1983) (2)
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- 26 Blockage of the potent estrogenic activity of 5-androstene-3 8, 17 β-diol (Δ5-diol) and dehydroepiandrosterone (DHEA) by the antiestrogen LY-156758 in rat anterior pituitary cells in culture (1985) (2)
- Detection of frequent BglII polymorphism by polymerase chain reaction and TaqI restriction fragment length polymorphism for 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase at the human HSDβ3 locus (1p11–p13) (1991) (2)
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- 1447 – EVIDENCE FOR A PHYSIOLOGICAL ROLE OF ENDORPHINS IN THE CONTROL OF PROLACTIN SECRETION IN THE RAT AND HUMAN (1978) (2)
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- BRIEF REPORT The Uridine Diphosphate Glucuronosyltransferase 2B15 D 85 Y and 2B17 Deletion Polymorphisms Predict the Glucuronidation Pattern of Androgens and Fat Mass in Men (2007) (1)
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- Combination Therapy with Flutamide and Castration (by LHRH Agonist or Orchiectomy): The Minimal Endocrine Therapy in Prostate Cancer (1987) (0)
- Novel therapeutic medicine using lh-rh agonist (1993) (0)
- Interactions among LH, FSH, PRL, LH-RH, and Sex Steroids in the Control of Testicular LH, FSH, and PRL Receptors in the Rat (1981) (0)
- Antiestrogenic activity of LY156758 in adenohypophysial cells in culture (1984) (0)
- Crystal structure of human androgen receptor ligand binding domain in complex with tetrahydrogestrinone (2006) (0)
- Intermittent intranasal LHRH agonist dosing sequentially combined with an oral progestagen as antiovulatory contraceptive approach (1984) (0)
- [I-131 HIPPURAN RENOGRAM. CLINICAL EXPERIENCE]. (1963) (0)
- [Specific role of sex steroids on the pituitary level. Sex steroids and anterior pituitary secretion]. (1978) (0)
- The compounds and process for their preparation containing benzopyran (1997) (0)
- Modulators abcd3 carrier in the treatment of acne or of hyperseborrhoea (2006) (0)
- 142. Long-term (5-month treatment) inhibitory effects of combined administration of an lhrh agonist and a pure antiandrogen on secondary sex organ weight in the male rat (1982) (0)
- components in the mouse uterus and MKP and downregulation of IGF-I pathway key Temporal analysis of E2 transcriptional induction of PTP (2013) (0)
- A WALK THROUGH LUCIANO’S ROLE IN INTERNATIONAL MEETINGS AND THE ROAD TO A NOVEL UNDERSTANDING OF SEX STEROID PHYSIOLOGY (2020) (0)
- Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone (2002) (0)
- Subject Index, Vol. 73, 1996 (1996) (0)
- Bicalutamide versus flutamide in combination therapy. (1999) (0)
- EFFECT OF NEOADJUVANT AND ADJUVANT COMBINED ANDROGEN BLOCKADE ASSOCIATED WITH RADIATION THERAPY ON PSA FAILURE IN T2-T3 PROSTATE CANCER (1999) (0)
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