Ferry Breedveld | Academic Influence

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Ferry Breedveld

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Computer Science

Ferry Breedveld's Degrees

PhD Computer Science Delft University of Technology
Masters Computer Science Delft University of Technology
Bachelors Computer Science Delft University of Technology

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Why Is Ferry Breedveld Influential?

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According to Wikipedia, Ferdinand Christoffel "Ferry" Breedveld is a Dutch rheumatologist. He was a professor of internal medicine, specializing in rheumatology, at Leiden University from 1991 to 2015. He served as chair of the board of directors of the Leiden University Medical Center from 2006 to 2015.

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Ferry Breedveld's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs (2010) (4048)
Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial (1999) (2434)
Treating rheumatoid arthritis to target: recommendations of an international task force (2010) (1927)
The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. (2006) (1853)
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. (1998) (1712)
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update (2013) (1711)
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. (2005) (1537)
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. (2000) (1533)
Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force (2015) (1155)
Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial (2008) (796)
How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. (2002) (793)
Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies. (2001) (620)
Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. (1997) (599)
Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis. (1999) (598)
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. (2005) (594)
Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate. (2004) (540)
The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. (2009) (527)
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis (2005) (483)
Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. (2005) (477)
Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial. (2007) (413)
Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. (1996) (410)
Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time. (1999) (407)
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. (2004) (392)
Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis (2011) (391)
A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions. (2007) (379)
The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. (2006) (379)
Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles (2005) (339)
SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS (1988) (311)
Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. (2000) (307)
Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. (1996) (305)
Validity and reliability of the twenty-eight-joint count for the assessment of rheumatoid arthritis activity. (1995) (301)
Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation. (1995) (296)
Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial. (2003) (286)
Asymptomatic synovitis precedes clinically manifest arthritis. (1998) (286)
Evidence for treating rheumatoid arthritis to target: results of a systematic literature search (2010) (280)
Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update (2015) (276)
Rheumatoid arthritis is a heterogeneous disease: evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. (2003) (271)
Comparison of manual therapy and exercise therapy in osteoarthritis of the hip: a randomized clinical trial. (2004) (256)
A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. (2006) (250)
Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? (1997) (240)
Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response. (2006) (236)
Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. (1995) (233)
TNF-α promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients (1997) (232)
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes. (2006) (224)
Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. (1999) (217)
Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis (2008) (210)
Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. (2002) (210)
Correlation of polymorphic variation in the promoter region of the interleukin‐1β gene with secretion of interleukin‐1β protein (2004) (202)
Comparison of Treatment Strategies in Early Rheumatoid Arthritis (2007) (200)
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. (2001) (199)
T Cells Cloned from Human Rheumatoid Synovial Membrane Functionally Represent the Th 1 Subset (1992) (195)
Diagnosis and course of early-onset arthritis: results of a special early arthritis clinic compared to routine patient care. (1998) (194)
TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. (2000) (184)
Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis. (2005) (184)
Leflunomide: mode of action in the treatment of rheumatoid arthritis (2000) (183)
Effect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial (2000) (178)
IgG autoantibodies against C1q are correlated with nephritis, hypocomplementemia, and dsDNA antibodies in systemic lupus erythematosus. (1991) (172)
Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus. (1995) (171)
Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis (2003) (171)
Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. (1997) (168)
Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study (2004) (168)
Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis (2008) (166)
Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis. (1997) (164)
The Leiden Early Arthritis Clinic. (2003) (164)
Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study. (1991) (164)
Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine. (1999) (163)
Using internet technology to deliver a home-based physical activity intervention for patients with rheumatoid arthritis: A randomized controlled trial. (2006) (162)
Consensus-based recommendations for the use of biosimilars to treat rheumatological diseases (2017) (159)
Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis. (1999) (158)
Elderly-onset rheumatoid arthritis. (1994) (158)
Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study. (1992) (154)
Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis (2004) (154)
Factors predicting outcome of rheumatoid arthritis: results of a followup study. (1993) (154)
A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. (1995) (153)
How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion. (2002) (153)
Randomised placebo-controlled study of stopping second-line drugs in rheumatoid arthritis (1996) (152)
Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity (2000) (152)
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. (1999) (151)
Quantification of the cell infiltrate in synovial tissue by digital image analysis. (2000) (150)
Comparison of the responsiveness of the Harris Hip Score with generic measures for hip function in osteoarthritis of the hip (2003) (148)
Radiographic damage of large joints in long-term rheumatoid arthritis and its relation to function. (2000) (147)
Displacement of Linker for Activation of T Cells from the Plasma Membrane Due to Redox Balance Alterations Results in Hyporesponsiveness of Synovial Fluid T Lymphocytes in Rheumatoid Arthritis (2000) (147)
The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis (2010) (145)
Comparison of high and low intensity training in well controlled rheumatoid arthritis. Results of a randomised clinical trial. (1996) (145)
Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case-control study. (1996) (145)
Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. (1998) (145)
Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis (2003) (143)
Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial (2009) (143)
Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors (2002) (141)
Expression of adhesion molecules in early rheumatoid synovial tissue. (1995) (140)
Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers. (1998) (140)
Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis (1998) (138)
Osteoarthritis--the impact of a serious disease. (2004) (138)
Aiming at low disease activity in rheumatoid arthritis with initial combination therapy or initial monotherapy strategies: the BeSt study. (2006) (138)
Cost effectiveness and cost utility analysis of multidisciplinary care in patients with rheumatoid arthritis: a randomised comparison of clinical nurse specialist care, inpatient team care, and day patient team care (2003) (137)
Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. (1994) (137)
Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis. (2005) (136)
Rheumatoid arthritis joint progression in sustained remission is determined by disease activity levels preceding the period of radiographic assessment. (2009) (135)
Rituximab Pharmacokinetics in Patients With Rheumatoid Arthritis: B‐Cell Levels Do Not Correlate With Clinical Response (2007) (134)
Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy. (1998) (133)
Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus. (1993) (132)
Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. (2000) (129)
Predicting functional status in patients with rheumatoid arthritis. (1999) (129)
Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis. (1992) (129)
Long-term outcome in rheumatoid arthritis: a simple algorithm of baseline parameters can predict radiographic damage, disability, and disease course at 12-year followup. (2002) (129)
Infliximab and methotrexate as induction therapy in patients with early rheumatoid arthritis. (2007) (126)
Long term high intensity exercise and damage of small joints in rheumatoid arthritis (2004) (125)
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. (2002) (125)
INCREASED EXPRESSION OF IL‐15 IN THE SYNOVIUM OF PATIENTS WITH RHEUMATOID ARTHRITIS COMPARED WITH PATIENTS WITH YERSINIA‐INDUCED ARTHRITIS AND OSTEOARTHRITIS (1997) (125)
The influence of tetracyclines on T cell activation (1995) (124)
Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo (2002) (123)
An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. (2005) (120)
HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis. (1999) (120)
Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions (2012) (120)
Appropriate and effective management of rheumatoid arthritis (2004) (118)
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3 (2003) (118)
Outcome of rheumatoid arthritis in relation to age and rheumatoid factor at diagnosis. (1993) (118)
Progression of joint damage in early rheumatoid arthritis: association with HLA-DRB1, rheumatoid factor, and anti-citrullinated protein antibodies in relation to different treatment strategies. (2008) (118)
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8) (2000) (118)
A randomized comparison of care provided by a clinical nurse specialist, an inpatient team, and a day patient team in rheumatoid arthritis. (2002) (118)
Two-year clinical and radiographic results with combination etanercept-methotrexate therapy versus monotherapy in early rheumatoid arthritis: a two-year, double-blind, randomized study. (2010) (117)
The tetracycline derivative minocycline differentially affects cytokine production by monocytes and T lymphocytes (1996) (117)
Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis (2008) (115)
Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: a systematic literature review for the 2019 update of EULAR recommendations (2019) (113)
Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritis. (1999) (111)
Remission of Behçet's syndrome with tumour necrosis factor α blocking therapy (2001) (109)
Two-year follow-up of a randomized controlled trial of a clinical nurse specialist intervention, inpatient, and day patient team care in rheumatoid arthritis. (2003) (107)
Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study (2005) (105)
Are differences in interleukin 10 production associated with joint damage? (2000) (104)
Slowing of bone loss in patients with rheumatoid arthritis by long-term high-intensity exercise: results of a randomized, controlled trial. (2004) (102)
Cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis. (2009) (102)
Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score (2007) (101)
Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement (2012) (101)
Dendritic cells and high endothelial venules in the rheumatoid synovial membrane. (1990) (101)
Childhood-onset Systemic Lupus Erythematosus: clinical presentation and prognosis in 31 patients. (1999) (100)
Early agalactosylation of IgG is associated with a more progressive disease course in patients with rheumatoid arthritis: results of a follow-up study. (1994) (100)
Diagnostic and prognostic characteristics of the enzyme linked immunosorbent rheumatoid factor assays in rheumatoid arthritis. (1996) (99)
Changes in bone mineral density in patients with recent onset, active rheumatoid arthritis (2007) (98)
Undifferentiated arthritis--disease course assessed in several inception cohorts. (2004) (98)
p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. (1999) (97)
Effect of Redox Balance Alterations on Cellular Localization of LAT and Downstream T-Cell Receptor Signaling Pathways (2002) (97)
Detection of bacterial DNA in serial synovial samples obtained during antibiotic treatment from patients with septic arthritis. (1999) (95)
T cell receptors in rheumatoid arthritis. (1995) (94)
Treating Rheumatoid Arthritis to Target: multinational recommendations assessment questionnaire (2011) (93)
Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis. (1996) (91)
Treatment with monoclonal anti-tumor necrosis factor alpha antibody results in an accumulation of Th1 CD4+ T cells in the peripheral blood of patients with rheumatoid arthritis. (1999) (89)
The effects of interferon-β treatment on synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis (2000) (88)
Disease Activity, Physical Function, and Radiographic Progression After Longterm Therapy with Adalimumab Plus Methotrexate: 5-Year Results of PREMIER (2010) (88)
Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study (2008) (87)
Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes (1999) (86)
An open-label pilot study of the effectiveness of adalimumab in patients with rheumatoid arthritis and previous infliximab treatment: relationship to reasons for failure and anti-infliximab antibody status (2008) (86)
The relation between class-specific serum rheumatoid factors and age in the general population. (1993) (85)
A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study) (1998) (84)
Are Patients With Rheumatoid Arthritis Less Physically Active Than the General Population? (2007) (84)
IgG and IgA antibodies to the collagen-like region of C1q in rheumatoid vasculitis. (1990) (83)
Criteria for early rheumatoid arthritis: from Bayes' law revisited to new thoughts on pathogenesis. (2002) (83)
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. (2001) (83)
Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. (1994) (82)
Anti-endothelial cell antibodies in patients with rheumatoid arthritis complicated by vasculitis. (1989) (82)
Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis. (2005) (81)
The effects of interferon beta treatment on arthritis. (1999) (81)
Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis. (1998) (81)
Functional Analysis of a Human Tumor Necrosis Factor α (TNF-α) Promoter Polymorphism Related to Joint Damage in Rheumatoid Arthritis (1998) (80)
The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel (2010) (80)
T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis (2004) (80)
Distribution of T cells and signs of T-cell activation in the rheumatoid joint: implications for semiquantitative comparative histology. (1998) (78)
Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation. (1995) (78)
Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD): a systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD (2019) (77)
Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health. (2006) (75)
Sociodemographic factors and the outcome of rheumatoid arthritis in young women. (1994) (75)
Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis (2004) (75)
Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis. (2004) (75)
Analysis of serial synovial biopsies in patients with rheumatoid arthritis: description of a control group without clinical improvement after treatment with interleukin 10 or placebo. (1999) (74)
Difference in expression of the plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis. (1996) (74)
Minocycline treatment for rheumatoid arthritis: an open dose finding study. (1990) (73)
IL‐6‐induced anaemia in rats: possible pathogenetic implications for anaemia observed in chronic inflammations (1996) (73)
Follow-up standards and treatment targets in rheumatoid arthritis: results of a questionnaire at the EULAR 2008 (2009) (73)
Rap1 Signaling Is Required for Suppression of Ras-Generated Reactive Oxygen Species and Protection Against Oxidative Stress in T Lymphocytes1 (2004) (73)
The value of early intervention in RA—a window of opportunity (2011) (73)
Characterization of anti‐endothelial cell antibodies in systemic lupus erythematosus (SLE) (1991) (73)
Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis (2007) (71)
Feasibility of adenovirus-mediated nonsurgical synovectomy in collagen-induced arthritis-affected rhesus monkeys. (1999) (71)
Minimal clinically important difference module: summary, recommendations, and research agenda. (2001) (71)
Pregnancy and oral contraceptive use do not significantly influence outcome in long term rheumatoid arthritis (2002) (71)
Leflunomide: a manageable safety profile. (2004) (70)
Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue. (1998) (70)
Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial) (2007) (70)
Regulation of synovial B cell survival in rheumatoid arthritis by vascular cell adhesion molecule 1 (CD106) expressed on fibroblast-like synoviocytes. (2000) (69)
Understanding emerging treatment paradigms in rheumatoid arthritis (2011) (69)
Measurement of cytokine and adhesion molecule expression in synovial tissue by digital image analysis (2001) (69)
The mortality of rheumatoid vasculitis compared with rheumatoid arthritis. (1996) (68)
Expression of the activation antigen CD27 in rheumatoid arthritis. (1996) (68)
An open study of pentoxyfylline and thalidomide as adjuvant therapy in the treatment of rheumatoid arthritis. (1996) (67)
The two-year follow-up of a randomized comparison of in-patient multidisciplinary team care and routine out-patient care for active rheumatoid arthritis. (1997) (67)
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis (2004) (67)
Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab. (2006) (67)
Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper (2007) (66)
T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. (1993) (65)
Engagement and satisfaction with an Internet-based physical activity intervention in patients with rheumatoid arthritis. (2007) (65)
Randomized comparison of a multidisciplinary job-retention vocational rehabilitation program with usual outpatient care in patients with chronic arthritis at risk for job loss. (2005) (64)
Consensus statement on the initiation and continuation of tumour necrosis factor blocking therapies in rheumatoid arthritis* (2000) (64)
An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition (1998) (63)
Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis. (2008) (63)
Treatment of recent-onset rheumatoid arthritis: lessons from the BeSt study. (2007) (63)
Efficacy of cyclooxygenase-2-specific inhibitors. (2001) (61)
Diagnostic strategy for the assessment of rheumatoid vasculitis (2003) (61)
Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patients. (1998) (60)
Are magnetic resonance flexion views useful in evaluating the cervical spine of patients with rheumatoid arthritis? (2000) (60)
Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. (2007) (60)
Prognostic factors in rheumatoid arthritis. (1996) (60)
Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis. (2005) (59)
Innate production of tumour necrosis factor α and interleukin 10 is associated with radiological progression of knee osteoarthritis (2007) (59)
Remission of Behçet's syndrome with tumour necrosis factor alpha blocking therapy. (2001) (59)
Detection of mycobacteria in joint samples from patients with arthritis using a genus-specific polymerase chain reaction and sequence analysis. (1999) (59)
Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation. (2005) (58)
Prednisone plus azathioprine treatment in patients with rheumatoid arthritis complicated by vasculitis. (1991) (57)
Ectopic production of 1,25‐dihydroxyvitamin D by B‐cell lymphoma as a cause of hypercalcemia (1987) (57)
CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis. (2002) (56)
Controversies in COX-2 selective inhibition. (2002) (55)
Longterm Effect of Delaying Combination Therapy with Tumor Necrosis Factor Inhibitor in Patients with Aggressive Early Rheumatoid Arthritis: 10-year Efficacy and Safety of Adalimumab from the Randomized Controlled PREMIER Trial with Open-label Extension (2014) (55)
Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity (2006) (55)
A randomized clinical trial of in-patient multidisciplinary treatment versus routine out-patient care in active rheumatoid arthritis. (1996) (55)
The relationship between serum titers of autoantibodies to C1q and age in the general population and in patients with systemic lupus erythematosus. (1993) (55)
Dominant T‐Cell Receptor β‐Chain Gene Rearrangements Indicate Clonal Expansion in the Rheumatoid Joint (1990) (54)
The need for new classification criteria for rheumatoid arthritis. (2005) (53)
IgG and IgA autoantibodies to C1q in systemic and renal diseases. (1992) (53)
Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study. (1997) (53)
Primary Sjögren's syndrome: clinical spectrum and mode of presentation based on an analysis of 50 patients selected from a department of rheumatology. (1992) (52)
Magnetic resonance imaging in the evaluation of patients with rheumatoid arthritis and subluxations of the cervical spine. (1987) (51)
Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. (2000) (51)
The “Shrinking lung syndrome” in SLE, treatment with theophylline (1993) (50)
An HLA-DRB1-Derived Peptide Associated with Protection Against Rheumatoid Arthritis Is Naturally Processed by Human APCs1 (2001) (50)
Discordance between objective and subjective assessment of functional ability of patients with rheumatoid arthritis. (1995) (49)
Synovial biopsy in arthritis research: five years of concerted European collaboration (2000) (48)
CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells. (2006) (48)
Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis (1999) (47)
Rheumatoid factor isotypes in serum and salivary fluid of patients with primary Sjögren's syndrome. (1993) (47)
Anti-CD4 monoclonal antibody for relapsing polychondritis (1991) (46)
Polymorphism within the tumor necrosis factor alpha (TNF) promoter region in patients with ankylosing spondylitis. (1999) (46)
Arthritis of the large joints—in particular, the knee—at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis (2006) (46)
Measurement of morning stiffness in rheumatoid arthritis clinical trials. (1997) (46)
Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis. (1994) (45)
Tumor necrosis factor α-308 gene variants in relation to major histocompatibility complex alleles and Felty's syndrome (1994) (45)
The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis. (2000) (45)
The effect of minocycline in rat models of inflammatory arthritis: correlation of arthritis suppression with enhanced T cell calcium flux. (1996) (45)
Evaluation of joint mobility in rheumatoid arthritis trials: the value of the EPM-range of motion scale. (1993) (44)
Neurologic dysfunction in patients with rheumatoid arthritis of the cervical spine. Predictive value of clinical, radiographic and MR imaging parameters (2001) (44)
Withdrawal of longterm antihyperuricemic therapy in tophaceous gout. (1993) (44)
99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis. (1992) (44)
Evidence for a protective role of the human leukocyte antigen class II region in early rheumatoid arthritis. (2001) (44)
Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies (2011) (43)
Characterization of anti-endothelial antibodies in patients with rheumatoid arthritis complicated by vasculitis. (1991) (43)
Manual therapy in osteoarthritis of the hip: outcome in subgroups of patients. (2005) (43)
Lack of T cell oligoclonality in enzyme‐digested synovial tissue and in synovial fluid in most patients with rheumatoid arthritis (1991) (42)
Effect of resumption of second line drugs in patients with rheumatoid arthritis that flared up after treatment discontinuation (1997) (42)
Female sex hormones at the onset of systemic lupus erythematosus affect survival. (1998) (42)
TNF-alpha blockade and tuberculosis: better look before you leap. (2003) (41)
Joint scintigraphy for quantification of synovitis with 99mTc-labelled human immunoglobulin G compared to late phase scintigraphy with 99mTc-labelled diphosphonate. (1994) (41)
Detection of Borrelia burgdorferi sensu stricto by reverse line blot in the joints of Dutch patients with Lyme arthritis. (1999) (41)
The cervical spine in rheumatoid arthritis: relationship between neurologic signs and morphology on MR imaging and radiographs (1996) (40)
Evidence for selective in vivo expansion of synovial tissue-infiltrating CD4+ CD45RO+ T lymphocytes on the basis of CDR3 diversity. (1994) (40)
Joint scintigraphy for quantification of synovitis with 99mTc-labelled human immunoglobulin G compared to histological examination. (1995) (40)
Quantitative detection of class-specific rheumatoid factors using mouse monoclonal antibodies and the biotin/streptavidin enhancement system. (1989) (40)
Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: a prospective longitudinal cohort study. (2007) (39)
ect of intensive exercise on patients with active rheumatoid arthritis : a randomised clinical trial (2000) (39)
The diagnostic value of salivary gland scintigraphy in patients suspected of primary Sjögren's syndrome. (1993) (39)
Coronary arteritis complicating rheumatoid arthritis. (1986) (39)
The limited value of the Health Assessment Questionnaire as an outcome measure in short term exercise trials. (1997) (39)
Depression of Tissue-Type Plasminogen Activator and Enhancement of Urokinase-Type Plasminogen Activator as an Expression of Local Inflammation (1992) (39)
Risk factors in familial osteoarthritis: the GARP sibling study. (2008) (38)
Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis. (2002) (38)
The efficacy of leflunomide monotherapy in rheumatoid arthritis: towards the goals of disease modifying antirheumatic drug therapy. (2004) (38)
The clinical significance of macrocytosis. (2009) (37)
Analysis of the effect of COX-2 specific inhibitors and recommendations for their use in clinical practice. (2000) (36)
The influence of synovial fluid on adenovirus-mediated gene transfer to the synovial tissue. (2001) (36)
Validation of a novel satisfaction questionnaire for patients with rheumatoid arthritis receiving outpatient clinical nurse specialist care, inpatient care, or day patient team care. (2003) (36)
99Tcm-labelled polyclonal human immunoglobulin G scintigraphy before and after intra‐articular knee injection of triamcinolone hexacetonide in patients with rheumatoid arthritis (1993) (36)
Imaging of inflammatory arthritis with technetium-99m-labeled IgG. (1989) (36)
Reading radiographs in pairs or in chronological order influences radiological progression in osteoarthritis. (2005) (35)
Rheumatoid vasculitis treated with infliximab. (2005) (35)
Immune complexes and the pathogenesis of neutropenia in Felty's syndrome. (1986) (35)
Using predicted disease outcome to provide differentiated treatment of early rheumatoid arthritis. (2006) (35)
Levels of circulating intercellular adhesion molecule-1 and -3 but not circulating endothelial leucocyte adhesion molecule are increased in patients with rheumatoid vasculitis. (1995) (35)
Presence of a population of CD20+, CD38- B lymphocytes with defective proliferative responsiveness in the synovial compartment of patients with rheumatoid arthritis. (2001) (34)
Abnormal clearance of soluble aggregates of human immunoglobulin G in patients with systemic lupus erythematosus. (1988) (34)
Rheumatoid arthritis in a population of persons aged 85 years and over. (1993) (34)
Effectiveness of the introduction of an International Classification of Functioning, Disability and Health-based rehabilitation tool in multidisciplinary team care in patients with rheumatoid arthritis. (2007) (34)
New insights in the pathogenesis of rheumatoid arthritis. (1998) (33)
Factors influencing the incidence of infections in Felty's syndrome. (1987) (33)
Minocycline in Rheumatoid Arthritis (1997) (33)
Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis. (1997) (33)
Detection of intracellular interferon‐γ by light microscopy using an immunoperoxidase technique: correlation with the corresponding mRNA and protein product (1993) (33)
FACTORS PREDICTING OUTCOME OF RHEUMATOID-ARTHRITIS - RESULTS OF A FOLLOW-UP-STUDY (VOL 20, PG 1288, 1993) (1993) (32)
Technetium-99m labelled human immunoglobulin scintigraphy predicts rheumatoid arthritis in patients with arthralgia. (1996) (32)
Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes (2006) (32)
Most people with rheumatoid arthritis undertake leisure- time physical activity and exercise in the Netherlands: an observational study (2007) (32)
Innovative treatment strategies for patients with rheumatoid arthritis (2008) (32)
Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells. (2007) (32)
Genetic linkage analysis of 14 candidate gene loci in a family with autosomal dominant osteoarthritis without dysplasia. (1997) (31)
IgA anti-dsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity. (1993) (31)
The diagnostic value of perivascular infiltrates in muscle biopsy specimens for the assessment of rheumatoid vasculitis (1998) (31)
Subcutaneous fat biopsy in the diagnosis of amyloidosis secondary to chronic arthritis. (1989) (31)
The severity of rheumatoid arthritis: a 6-year followup study of younger women with symptoms of recent onset. (1994) (30)
The accuracy of diagnosing neuropsychiatric systemic lupus erythematosus in a series of 49 hospitalized patients. (1999) (29)
Interleukin-6 activity in paired samples of synovial fluid. Correlation of synovial fluid interleukin-6 levels with clinical and laboratory parameters of inflammation. (1991) (29)
Lack of effect of doxycycline on disease activity and joint damage in patients with rheumatoid arthritis. A double blind, placebo controlled trial. (2001) (29)
Immune complexes in sera from patients with rheumatoid vasculitis induce polymorphonuclear cell-mediated injury to endothelial cells. (1988) (29)
Fixed-flexion knee radiography: the sensitivity to detect knee joint space narrowing in osteoarthritis. (2007) (29)
antirheumatic drugs: 2013 update synthetic and biological disease-modifying management of rheumatoid arthritis with EULAR recommendations for the (2013) (29)
Digital subtraction sialography of the parotid glands in primary Sjögren's syndrome. (1993) (29)
LONG-TERM COURSE AND OUTCOME OF FUNCTIONAL CAPACITY IN RHEUMATOID ARTHRITIS (1999) (29)
Value of serum cartilage oligomeric matrix protein as a prognostic marker of large-joint damage in rheumatoid arthritis--data from the RAPIT study. (2008) (29)
The effect of ranitidine on NSAID related dyspeptic symptoms with and without peptic ulcer disease of patients with rheumatoid arthritis and osteoarthritis (1996) (29)
A comparison of three radiologic scoring systems for the long-term assessment of rheumatoid arthritis: findings of an ongoing prospective inception cohort study of 132 women followed up for a median of twelve years. (2000) (29)
A comparative study of tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24-week analysis of a 1-year clinical trial. (1995) (28)
Parasympathetic dysfunction in rheumatoid arthritis patients with ocular dryness. (1996) (28)
New agents for scintigraphy in rheumatoid arthritis (1995) (28)
Probability of continued low disease activity in patients with recent onset rheumatoid arthritis treated according to the disease activity score (2007) (27)
Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone. (2001) (27)
Biologics in early rheumatoid arthritis. (2005) (27)
Human IgG Fc‐binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen‐dependent process of somatic hypermutation and clonal selection (2003) (27)
Efficacy of intraarticular infliximab in patients with chronic or recurrent gonarthritis: a clinical randomized trial. (2009) (27)
The usage of functional wrist orthoses in patients with rheumatoid arthritis (2008) (26)
Clinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early disease (2016) (26)
Subclass Distribution of IgA and IgG Antibodies Against Clq in Patients with Rheumatic Diseases (1995) (26)
Changes in outcome measures for impairment, activity limitation, and participation restriction over two years in osteoarthritis of the lower extremities. (2008) (26)
Interleukin-10 as an explanation for pregnancy-induced flare in systemic lupus erythematosus and remission in rheumatoid arthritis. (1999) (26)
Brain involvement in rheumatoid arthritis: a magnetic resonance spectroscopy study. (2009) (26)
Methods for the detection of anti-endothelial antibodies by enzyme-linked immunosorbent assay. (1991) (26)
Collagen arthritis in the rat is initiated by CD4+ T cells and can be amplified by iron. (1989) (26)
Autoantibodies to neutrophil cytoplasmic enzymes in Felty's syndrome. (1993) (26)
Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis. (1998) (25)
T‐Cell Receptor β‐Chain Gene Rearrangements of T‐Cell Populations Expanded from Multiple Sites of Synovial Tissue obtained from a Patient with Rheumatoid Arthritis (1992) (25)
Treatment with a chimeric CD4 monoclonal antibody is associated with a relative loss of CD4+/CD45RA+ cells in patients with rheumatoid arthritis. (1997) (25)
High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review. (2002) (25)
Phagocytosis and intracellular killing of Staphylococcus aureus by polymorphonuclear cells from synovial fluid of patients with rheumatoid arthritis. (1986) (25)
Phagocytosis and intracellular killing by polymorphonuclear cells from patients with rheumatoid arthritis and Felty's syndrome. (1985) (24)
Yersinia enterocolitica: a cause of chronic polyarthritis. (1997) (24)
Monoclonal antibodies to CD4. (1998) (24)
IgG autoantibodies to C1q do not detectably influence complement activation in vivo and in vitro in systemic lupus erythematosus (1992) (24)
Antibodies against C1q in anti‐glomerular basement membrane nephritis (1992) (22)
Catastrophic manifestation of the antiphospholipid syndrome. (1999) (22)
Elimination of soluble 123I-labeled aggregates of IgG in patients with systemic lupus erythematosus. Effect of serum IgG and numbers of erythrocyte complement receptor type 1. (1991) (22)
Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G (1991) (21)
Recruitment of patients with early rheumatoid arthritis -- the Netherlands experience. (1996) (21)
Neutropenia and infections in Felty's syndrome. (1988) (21)
Levels of circulating cellular fibronectin are increased in patients with rheumatoid vasculitis. (1998) (21)
Current and future management approaches for rheumatoid arthritis (2002) (21)
Combination Therapy for Rheumatoid Arthritis (2001) (21)
Antiendothelial cell antibodies in systemic lupus erythematosus: enhanced antibody binding to interleukin-1-stimulated endothelium. (1994) (20)
Most people with rheumatoid arthritis undertake leisure-time physical activity in the Netherlands: an observational study. (2007) (20)
Methotrexate treatment and mortality in rheumatoid arthritis (2002) (20)
Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate: the DINORA trial (2018) (20)
Technetium-99m labelled polyclonal human IgG scintigraphy before and 26 weeks after initiation of parenteral gold treatment in patients with rheumatoid arthritis. (1995) (19)
Future trends in the treatment of rheumatoid arthritis: cytokine targets. (1999) (19)
Detection of a C-insertion polymorphism within the human tumor necrosis factor alpha (TNFA) gene (1995) (19)
Rheumatoid factor production by mononuclear cells derived from different sites of patients with rheumatoid arthritis (1993) (19)
The spleen in Felty's syndrome: A histological, morphometrical, and immunohistochemical study (1988) (19)
A comparison of the OARSI response criteria with patient's global assessment in patients with osteoarthritis of the hip treated with a non-pharmacological intervention. (2006) (18)
Anti-lactoferrin antibodies in patients with rheumatoid arthritis with vasculitis. (1993) (17)
Analysis of serial synovial biopsies as a screening method for predicting the effects of therapeutic interventions. (1997) (17)
Humoral immunity and composition of immune complexes in patients with rheumatoid arthritis, with special reference to IgE-containing immune complexes. (1989) (17)
High dose intravenous gamma globulin for Felty's syndrome. (1985) (17)
Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cells (2001) (16)
Tumor necrosis factor alpha-308 gene variants in relation to major histocompatibility complex alleles and Felty's syndrome. (1994) (16)
Lack of evidence for the presence of neutrophil autoantibodies in the serum of patients with Felty's syndrome (1988) (16)
Polyreactivity of human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis. (2002) (16)
Granulocyte-macrophage colony-stimulating factor treatment of neutropenia associated with Felty's syndrome. (1990) (16)
The diagnostic value of streptococcal serology in early arthritis: a prospective cohort study. (2000) (16)
HLA-DRB1, DQA1, and DQB1 genotypes and risk of vasculitis in patients with rheumatoid arthritis. (1997) (15)
Remission rates in subjects with active early rheumatoid arthritis - 1 year results of the comet trial (2007) (15)
Bisphosphonates in collagen arthritis (2004) (15)
Elastase and collagenase activities in synovial fluid of patients with arthritis. (1987) (15)
Inflamed joints of patients with rheumatoid arthritis contain T cells that display in vitro proliferation to antigens present in autologous synovial fluid. Functional analysis on the basis of synovial-fluid-reactive T-cell clones and lines. (1994) (15)
Does cyclosporin A cause cancer? (1999) (15)
In-patient treatment for active rheumatoid arthritis: clinical course and predictors of improvement. (1995) (15)
Vasculitis due to cholesterol embolism. (1997) (15)
Case Report: Severe Hepatitis and Pure Red Cell Aplasia in Adult Still's Disease Good Response to Immunosuppressive Therapy (1999) (15)
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial. (2008) (15)
New tumor necrosis factor-alpha biologic therapies for rheumatoid arthritis. (1998) (14)
CD28 co‐stimulation is intact and contributes to prolonged ex vivo survival of hyporesponsive synovial fluid T cells in rheumatoid arthritis (1998) (14)
Anterior spinal artery syndrome in systemic lupus erythematosus. (1989) (14)
Reduced cellularity and expression of adhesion molecules and cytokines after treatment with soluble human recombinant TNF receptor (P75) in RA patients (1999) (14)
Joint-derived T cells in rheumatoid arthritis proliferate to antigens present in autologous synovial fluid. (1995) (14)
Progress in the understanding of inducible models of chronic arthritis. (1987) (14)
T cells in rheumatoid arthritis. (1997) (14)
Tyrosine kinase inhibition (2011) (14)
Does partial control of inflammation prevent long-term joint damage? Clinical rationale for combination therapy with multiple disease-modifying antirheumatic drugs. (1999) (13)
Monoclonal antibody therapy of inflammatory rheumatic diseases. (1995) (13)
Therapeutic Regulation of T Cells in Rheumatoid Arthritis (1995) (13)
Recommendations for an update of 2003 European regulatory requirements for registration of drugs to be used in the treatment of RA (2011) (13)
Molecular analysis of the T‐cell receptor β‐chain repertoire in early rheumatoid arthritis: heterogeneous TCRBV gene usage with shared amino acid profiles in CDR3 regions of T lymphocytes in multiple synovial tissue needle biopsies from the same joint (1996) (13)
Detection of arthritogenic factor in adjuvant arthritis. (1988) (13)
Subclass distribution and size of human IgA rheumatoid factor at mucosal and nonmucosal sites. (1991) (13)
Roundtable on biosimilars with European regulators and medical societies, Brussels, Belgium, 12 January 2016 (2016) (13)
CNS involvement in systemic lupus erythematosus: a case with remarkable histopathological findings (2001) (12)
Rheumatoid arthritis with vertical atlanto-axial subluxation complicated by hydrocephalus. (1987) (12)
Bone marrow IgA and IgA subclass synthesis in ankylosing spondylitis. (1992) (12)
Effect of medial tibial plateau alignment on serial radiographs on the capacity to predict progression of knee osteoarthritis. (2008) (12)
Chloroquine Therapy in Patients with Recent-Onset Rheumatoid Arthritis: The Clinical Response can be Predicted by the Low Level of Acute-Phase Reaction at Baseline (1999) (12)
Current perspectives on synovitis (1999) (11)
Flexion contractures associated with a malignant neoplasm: ‘A paraneoplastic syndrome?’ (2005) (11)
Intranasal administration of recombinant human cartilage glycoprotein-39 as a treatment for rheumatoid arthritis: a phase II, multicentre, double-blind, randomised, placebo-controlled, parallel-group, dose-finding trial (2009) (11)
C3 receptors on granulocytes from patients with rheumatoid arthritis and Felty's syndrome. (1984) (11)
Inhibition of polymorphonuclear leukocyte-mediated endothelial cell detachment by antileukoprotease: a comparison with other proteinase inhibitors. (1991) (11)
Cigarette smoking and pulmonary diffusion defects in rheumatoid arthritis (1998) (11)
Differential therapy in early and late stages of rheumatoid arthritis. (1996) (11)
Leflunomide in combination therapy (2004) (10)
Immune ablation and stem-cell therapy in autoimmune disease: Introduction (2000) (10)
Allele-specific quantification of TNFA transcripts in rheumatoid arthritis (1996) (10)
Rapidly progressive glomerulonephritis with glomerular crescent formation in rheumatoid arthritis (1985) (10)
Clinical significance of a low serum alkaline phosphatase. (1992) (10)
Antinuclear antibodies in psychiatric patients (1994) (10)
Measurement of synovial inflammation in rheumatoid arthritis with technetium 99m labelled human polyclonal immunoglobulin G (2004) (10)
Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage (2007) (10)
CNS involvement in primary Sjögren’s syndrome: a case with a clue for the pathogenesis (2000) (10)
Increased cellularity and expression of adhesion molecules in muscle biopsy specimens from patients with rheumatoid arthritis with clinical suspicion of vasculitis, but negative routine histology (2000) (10)
Reduction in cellularity and expression of adhesion molecules in rheumatoid synovial tissue after anti-TNFα monoclonal antibody treatment. (1996) (10)
T cell vaccination in rheumatoid arthritis. (1991) (10)
New perspectives on treating rheumatoid arthritis. (1995) (9)
Direct assessment of junctional diversity in rearranged T cell receptor beta chain encoding genes by combined heteroduplex and single strand conformation polymorphism (SSCP) analysis. (1996) (9)
Chorioretinopathy in primary antiphospholipid syndrome: a case report. (1998) (9)
Characterization of the hyporesponsiveness of synovial T cells in rheumatoid arthritis: role of chronic oxidative stress (1998) (9)
Autoantibodies against C1q in systemic lupus erythematosus. (1993) (9)
Linker for activation of T cells: sensing redox imbalance. (2002) (9)
The effect of promoter strength in adenoviral vectors in hyperplastic synovium. (2000) (9)
[Diagnosis and course of early arthritis; study in a specialized clinic for early arthritis]. (1996) (8)
IgA containing immune complexes and hematuria in ankylosing spondylitis. A prospective longitudinal study. (1988) (8)
Methotrexate treatment and mortality in rheumatoid arthritis. Authors' reply (2002) (8)
The plasminogen activation system in rheumatoid arthritis (1996) (8)
Do patients with systemic sclerosis have abnormal gallbladder function? (1997) (8)
Responsiveness of the shoulder function assessment scale in patients with rheumatoid arthritis (2006) (8)
IgA rheumatoid factor in mucosal fluids and serum of patients with rheumatoid arthritis: immunological aspects and clinical significance (1992) (8)
The diagnostic value of salivary fluid levels of β2-microglubulin, lysozyme and lactoferrin for primary Sjögren's synrome (1992) (8)
Evidence for Selective in Vivo Expansion of Synovial Tissue‐Infiltrating CD4+CD45RO+ T‐Lymphocytes on the Basis of CDR3 Diversity (1995) (8)
Anti-endothelial cell antibodies in patients with rheumatoid vasculitis. (1989) (8)
Rheumatoid arthritis with eosinophilic fasciitis and pure red cell aplasia. (1989) (7)
Fc receptors on granulocytes from patients with rheumatoid arthritis and Felty's syndrome. (1984) (7)
Cartilage invasion by rheumatoid synovial fibroblasts in vivo is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor: abstract (2000) (7)
Properdin factor B and complement factor C4 allotypes in rheumatoid arthritis: results of a follow-up study. (1992) (7)
Experimental arthritis in rats induced by intra-articular injection of IgE aggregates: evidence for arthritogenic role of complexed IgE. (1992) (7)
TNF-blockade and tuberculosis : better look before you leap (2003) (7)
Should rheumatoid arthritis be treated conservatively or aggressively? (2003) (7)
Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis (2005) (7)
6 Vasculitis associated with connective tissue disease (1997) (7)
Tenidap, but not Nonsteroidal Anti‐Inflammatory Drugs, Inhibits T‐Cell Proliferation and Cytokine Induction (1995) (6)
Clinical trial and ‘real-world’ data support switching from a bio-originator to its biosimilar (2019) (6)
Gastric outlet obstruction as a presenting manifestation of systemic lupus erythematosus. (1994) (6)
Unproven hypothesis that leflunomide is better than methotrexate as measured by magnetic resonance imaging: comment on the article by Reece et al - Reply (letter) (2003) (6)
No therapeutic effect of plasmin antagonist tranexamic acid in rheumatoid arthritis. A double-blind placebo-controlled pilot study. (2003) (6)
Influence of blood and synovial fluid immune complexes of patients with rheumatoid arthritis on production of nitric oxide and growth and viability of chondrocytes. (2000) (6)
How to realize the potential of off-patent biologicals and biosimilars in Europe? Guidance to policymakers (2018) (6)
Achieving comprehensive disease control in patients with early and established rheumatoid arthritis treated with adalimumab plus methotrexate versus methotrexate alone (2017) (6)
Vasculitis associated with connective tissue disease. (1997) (6)
Value of 99mTc-IgG scintigraphy in the prediction of joint destruction in patients with rheumatoid arthritis of recent onset (2004) (6)
Cutaneous immunofluorescence in ankylosing spondylitis. Absence of correlation with disease activity. (1990) (5)
Role of liver endothelial and Kupffer cells in clearance of human Clq in rats (1993) (5)
Felty syndrome: autoimmune neutropenia or immune-complex-mediated disease? (2004) (5)
A 26-year-old woman with fever, migratory polyarthritis, and pericarditis subsequent to a T-cell lymphoma (1997) (5)
Clinical remission, radiographic non-progression, and normalized function with the combination of etanercept and methotrexate in the treatment of early active rheumatoid arthritis: 1-year results of the COMET trial (2008) (5)
Uptake and degradation of soluble aggregates of IgG by monocytes of patients with rheumatoid arthritis: relation to disease activity. (1991) (5)
Which clinical variables contribute to the physician's assessment of medium term outcome in rheumatoid arthritis? (1993) (5)
INTERNATIONAL JOURNAL OF ADVANCES IN (2007) (5)
The influence of synovial fibroblasts on the phagocytosis of Staphylococcus by polymorphonuclear cells (2004) (5)
Degradation of aggregates of activated C3 (C3b) by monocytes of patients with rheumatoid arthritis is related to vasculitis (1990) (5)
Rheumatoid factor production in the joint. (1995) (4)
Long-term use of adalimumab as monotherapy after attainment of low disease activity with adalimumab plus methotrexate in patients with rheumatoid arthritis (2018) (4)
Cytolytic activity in T cell clones derived from human synovial rheumatoid membrane: inhibition by synovial fluid (1990) (4)
InforMatrix®: treatment of rheumatoid arthritis using biologicals (2006) (4)
Regulation of Rheumatoid Factor Production by B Cells from Healthy Individuals and Patients with Rheumatoid Arthritis (1997) (4)
Multiple faces of rheumatoid arthritis: diagnostic and therapeutic algorithms. (2004) (4)
IgE-containing immune complexes in synovial fluid of patients with rheumatoid arthritis (1990) (4)
Influence of blood and synovial fluid immune complexes of rheumatoid arthritis patients on production of nitric oxide, growth and viability of chondrocytes (2000) (4)
Distal renal tubular acidosis in polyarteritis nodosa. (1986) (4)
Lefunomide in combination therapy. (2004) (4)
Vasculitis: mechanisms of injury (1996) (4)
Tumour necrosis factor blockade in rheumatoid arthritis. (2001) (4)
CD4 Monoclonal Antibody Therapy in Rheumatoid Arthritis (1996) (3)
T‐Cell Phenotypes after Stimulation of Human Mononuclear Cells by Pokeweed Mitogen or Pokeweed Mitogen Bound to Erythrocytes (1989) (3)
A Pilot Dose‐Finding Study of Etanercept in Rheumatoid Arthritis (2017) (3)
Advances in targeted therapies V (2003) (3)
5 Future treatment (1997) (3)
Systematic Review of Combination DMARD Therapy in Rheumatoid Arthritis (2000) (3)
A2 INNATE PRODUCTION OF TUMOR NECROSIS FACTOR-ALFA AND INTERLEUKIN-10 IS ASSOCIATED WITH PROGRESSION OF KNEE OSTEOARTHRITIS (2006) (3)
Rheumatic manifestations of hepatitis C virus infection. (1997) (3)
Exercise therapy in patients with rheumatoid arthritis (2002) (3)
Initial combination therapy with adalimumab and methotrexate sustains clinical remission and response for early RA patients treated through year 5 (2008) (3)
Anti-CD4 antibodies in rheumatoid arthritis. (1992) (3)
Updating the 2003 European regulatory requirements for registering disease-modifying drugs to be used in the treatment of rheumatoid arthritis. (2011) (3)
[Spondylodiscitis caused by Streptococcus agalactiae]. (1997) (2)
Standing Committee on Investigative Rheumatology (2001) (2)
Effect of monomeric immunoglobulin G (IgG) on the clearance of soluble aggregates of IgG in man. (1991) (2)
Reactivity and Self‐Association In Vivo of a Human Monoclonal IgG Rheumatoid Factor (1992) (2)
THU0190 Long-Term Impact of Delaying Combination Therapy with Adalimumab Plus Methotrexate by 2 Years in Patients with Early Rheumatoid Arthritis: Final 10-Year Results of the Premier Trial (2013) (2)
Persistent CD3‐Crosslinking Down‐Regulates Interleukin‐2 Responsiveness in Interleukin‐2‐Competent Cloned T Cells: the Possible Involvement of Protein Kinase C (1996) (2)
Mononuclear phagocyte system Fc-receptor function in patients with seropositive rheumatoid arthritis. (1987) (2)
The clinical spectrum of giant cell arteritis. (1993) (2)
F.40. Relationship Between Clinical Response, Rituximab (Rtx) Pharmacokinetics, and Peripheral B-Cell Levels in Rheumatoid Arthritis (RA) (2006) (1)
26. Disseminated thrombosis, an unusual and catastrophic manifestation of the antiphospholipid syndrome (1997) (1)
Possibilities for the immunotherapy of rheumatoid arthritis (1990) (1)
Muscle disorders111. The impact of fatigue in patients with idiopathic inflammatory myopathy: a mixed method study (2012) (1)
HLA-DRB1 alleles and risk of vasculitis in rheumatoid arthritis; genetic heterogeneity between clinical subgroups of vasculitis (1996) (1)
Early rheumatoid arthritis. Future treatment. (1997) (1)
Evidence for selective usage of amino acids within CDR3 regions of T cell receptor V genes derived from synovial tissue-infiltrating CD4+CD45RO+ T-lymphocytes. (1995) (1)
Nephritis and dermatitis in systemic lupus erythematosus sle are strongly associated with the occurrence of igg autoantibodies c1qab against the first subcomponent of complement (1989) (1)
Possibility and safety of gene transfer to inflamed synovial tissue after intra-articular administration (1997) (1)
An approach to therapeutic trials in rheumatology: the foundation for applied rheumatology research. (1996) (1)
239 PROGRESSION OF HAND OSTEOARTHRITIS OVER TWO YEARS: A CLINICAL AND RADIOLOGICAL FOLLOW-UP STUDY (2007) (1)
COMET results are not stellar – Authors' reply (2008) (1)
Functional analysis of the human tumor necrosis factor alpha (TNF) -238 promoter polymorphism (1997) (1)
Sustained clinical remission and response for early RA patients with adalimumab and methotrexate initial combination therapy: 5-year results of the PREMIER trial. (2009) (1)
TREATMENT OF RHEUMATOID-ARTHRITIS WITH ANTIBODY TO TNF-ALPHA DECREASES EXPRESSION AND SHEDDING OF E-SELECTIN (1995) (1)
Studies Including Therapeutics (ESCISIT) Standing Committee for International Clinical early arthritis: report of a task force of the European EULAR recommendations for the management of (2007) (1)
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UvA-DARE ( Digital Academic Repository ) T cells , fibroblast-like synoviocytes , and granzyme B plus cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis (2004) (0)
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Immunecomplexes andthepathogenesis of neutropenia inFelty's syndrome (1986) (0)
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E V ect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial (2000) (0)
Lymphocytes and Protection Against Oxidative Stress in T of Ras-Generated Reactive Oxygen Species Rap 1 Signaling Is Required for Suppression (2004) (0)
Cytokine-Suppressive Anti-Inflammatory Drugs (1996) (0)
Clinical, Radiologic, and Functional Outcomes Following Methotrexate Withdrawal in Etanercept-Treated Patients with Active Early Rheumatoid Arthritis: A Subanalysis of COMET Year 2 by Week 52 DAS28 Status (2021) (0)
cohort study (the Rotterdam study) radiological osteoarthritis in a population-based A genetic association study of the IGF-1 gene and (2006) (0)
Exposition ‘ 13 covers of the Netherlands Journal of Medicine (2003) (0)
EXTENDED REPORT Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis (2003) (0)
Thematic stream: inflammatory arthritis BPP1. Golimumab in Rheumatoid Arthritis Patients Previously Treated with Anti-Tnf Alpha Agents: 2 Year Results from go-after Study (2011) (0)
Comparison of Technetium-99m-Labelled Human Polyclonal Immunoglobulin Scintigraphy with Conventional Bone Scintigraphy in Patients with Rheumatoid Arthritis and Osteoarthritis (1994) (0)
Urokinase mediated, plasmin degradation of bone-like matrix (1995) (0)
Arthritis Therapy in Rheumatoid α Anti-TNF-and Acute-Phase Proteins Following Regulation of Cytokines , Cytokine Inhibitors , (1999) (0)
IMMUNOLOGY OF CONNECTIVE TISSUE DISEASE (1992) (0)
Degradation ofaggregates ofactivated C3 (C3b)bymonocytes of patients withrheumatoid arthritis isrelated tovasculitis (1990) (0)
PREMIER Longterm Therapy with Adalimumab Plus Methotrexate : 5-Year Results of Disease Activity , Physical Function , and Radiographic Progression After (2010) (0)
Lack of effect of doxyxyxline on disease activity and pyridinoline excretion rates in rheumatoid arthritis : a double-blind placebo-controlled study (2000) (0)
91 Experimental arthritis in rats induced by intra-articular injection of IgE-aggregates: Evidence for arthritogenic role of complexed IgE (1991) (0)
Leflunomide in treatment of rheumatoid arthritis. Author's reply (2002) (0)
Combination disease-modifying antirheumatic drug therapy in rheumatoid arthritis (1999) (0)
rheumatoid vasculitis Diagnostic strategy for the assessment of (2006) (0)
Immunological aspects of inflammatory rheumatic diseases: towards immunomodulation (2002) (0)
Regulation of rheumatoid factor production by peripheral blood and synovial fluid B cells in rheumatoid arthritis (1997) (0)
Investigational treatments in rheumatoid arthritis. (1999) (0)
AB0315 Reduction of Concomitant Oral Methotrexate or Corticosteroids in Combination Treatment with Adalimumab Does Not Affect Effectiveness in Patients with Rheumatoid Arthritis (2016) (0)
Anopen study ofpentoxyfylline andthalidomide asadjuvant therapy inthetreatmentof rheumatoid arthritis (2011) (0)
C3receptors ongranulocytes frompatients withrheumatoid arthritis andFelty's syndrome (1984) (0)
Cellular Interactions between Synovial T‐Cell Clones from a Patient with Rheumatoid Arthritis (1993) (0)
Regulation of IL-2 gene expression through CD28 is dependent on cooperativity between cis-acting promoter sequences (1997) (0)
Anti-endothelial cell antibodies inpatients with rheumatoid arthritis complicated byvasculitis (1989) (0)
P269 THE RELATIONSHIP BETWEEN RADIOGRAPHIC MEASUREMENT OF JOINT SPACE WIDTH AND MRI MEASUREMENTS OF CARTILAGE THICKNESS AND VOLUME IN OSTEOARTHRITIC AND CONTROL KNEES (2006) (0)
Rheumatology in the 21st century. (1999) (0)
Musculoskeletal disorders anddisability inpersons aged85andover:acommunity survey (1994) (0)
COMMENT ON: IS ONE YEAR EARLY, OR TOO LATE? AUTHORS' REPLY (1997) (0)
Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor (1999) (0)
252 PROGRESSION OF OSTEOARTHRITIS IN THE LOWER EXTREMITIES: A CLINICAL AND RADIOLOGICAL FOLLOW-UP STUDY. (2007) (0)
Gastric outlet obstruction asapresenting manifestation ofsystemic lupus erythematosus (1994) (0)
T cell directed therapies and biologics (1998) (0)
European rheumatology is advancing (2006) (0)
Quantitative Detection of Class-Specific Rheumatoid Factors and IgA Rheumatoid Factor Subclasses (1989) (0)
BeSt strategies in Rheumatoid Arthritis (BeSt) (2011) (0)
Difference in expression of plasminogen activators and plasminogen activator inhibitors in synovial tissue of patients with rheumatoid arthritis and osteoarthritis (1994) (0)
Antibodies against Clqinanti-glomerular basement membranenephritis (1992) (0)
58 The plaminogen activation system in bone and cartilage degradation in vitro and in vivo (1997) (0)

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