Florian Markowetz
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Why Is Florian Markowetz Influential?
(Suggest an Edit or Addition)According to Wikipedia, Florian Markowetz is the Professor of Computational Oncology at the University of Cambridge. He is a Senior Group Leader at the Cancer Research UK Cambridge Institute and Director and co-founder of Tailor Bio, a genomics company aiming to improve precision medicine for cancers with high levels of chromosomal instability.
Florian Markowetz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups (2012) (4591)
- Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions (2013) (684)
- The evolutionary history of 2,658 cancers (2017) (575)
- Acetylcysteine for prevention of contrast nephropathy: meta-analysis (2003) (480)
- Inferring cellular networks – a review (2007) (422)
- Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study (2016) (384)
- Patterns of somatic structural variation in human cancer genomes (2020) (377)
- Patterns of somatic structural variation in human cancer genomes (2020) (377)
- Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling (2012) (367)
- Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis (2015) (313)
- Systems-level dynamic analyses of fate change in murine embryonic stem cells (2009) (291)
- Cancer Evolution: Mathematical Models and Computational Inference (2014) (284)
- Copy-number signatures and mutational processes in ovarian carcinoma (2017) (258)
- Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (2020) (220)
- Comprehensive molecular characterization of mitochondrial genomes in human cancers (2017) (197)
- OncoNEM: inferring tumor evolution from single-cell sequencing data (2016) (188)
- Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (2020) (180)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2020) (166)
- Master regulators of FGFR2 signalling and breast cancer risk (2013) (166)
- Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes (2020) (166)
- Diverse epigenetic strategies interact to control epidermal differentiation (2012) (142)
- Phylogenetic Quantification of Intra-tumour Heterogeneity (2013) (136)
- Regulators of genetic risk of breast cancer identified by integrative network analysis (2015) (135)
- Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (2020) (128)
- Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry (2016) (119)
- Nested effects models for high-dimensional phenotyping screens (2007) (117)
- HTSanalyzeR: an R/Bioconductor package for integrated network analysis of high-throughput screens (2011) (116)
- BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies (2015) (111)
- Non-transcriptional pathway features reconstructed from secondary effects of RNA interference (2005) (104)
- Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier (2014) (96)
- Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial (2020) (89)
- Multi-omic machine learning predictor of breast cancer therapy response (2021) (86)
- A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes (2018) (85)
- RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations (2012) (84)
- Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes (2011) (82)
- Five selfish reasons to work reproducibly (2015) (78)
- All biology is computational biology (2017) (75)
- The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer (2019) (73)
- Reproducibility standards for machine learning in the life sciences (2021) (71)
- Unraveling tumor–immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy (2020) (70)
- Intratumor heterogeneity defines treatment‐resistant HER2+ breast tumors (2018) (66)
- Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas. (2016) (65)
- How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation Screens (2009) (63)
- Structure Learning in Nested Effects Models (2007) (58)
- Unraveling tumor–immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy (2018) (55)
- Neutral tumor evolution? (2017) (54)
- SANTA: Quantifying the Functional Content of Molecular Networks (2014) (51)
- Support Vector Machines for Protein Fold Class Prediction (2003) (49)
- KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice (2018) (48)
- A community effort to create standards for evaluating tumor subclonal reconstruction (2019) (46)
- Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types (2018) (45)
- Sex differences in oncogenic mutational processes (2019) (41)
- A phylogenetic latent feature model for clonal deconvolution (2016) (39)
- Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis (2017) (38)
- Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging. (2020) (38)
- Probabilistic Soft Interventions in Conditional Gaussian Networks (2005) (37)
- Differential C3NET reveals disease networks of direct physical interactions (2011) (36)
- A pan-cancer compendium of chromosomal instability (2022) (35)
- A Sparse Regulatory Network of Copy-Number Driven Gene Expression Reveals Putative Breast Cancer Oncogenes (2012) (34)
- High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations (2020) (34)
- Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning (2021) (34)
- How Subclonal Modeling Is Changing the Metastatic Paradigm (2016) (32)
- Dissecting cancer heterogeneity--an unsupervised classification approach. (2013) (31)
- Analyzing gene perturbation screens with nested effects models in R and bioconductor (2008) (31)
- Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma (2017) (31)
- Molecular Diagnosis (2005) (30)
- Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig (2020) (30)
- Tissue-specific and interpretable sub-segmentation of whole tumour burden on CT images by unsupervised fuzzy clustering (2020) (29)
- Intratumoral Heterogeneity of Glioblastoma Infiltration Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging. (2018) (29)
- Inferring structural variant cancer cell fraction (2020) (27)
- Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq (2018) (25)
- Support Vector Machines in Bioinformatics (2002) (25)
- Immunophenotypes of pancreatic ductal adenocarcinoma: Meta‐analysis of transcriptional subtypes (2019) (23)
- VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer (2019) (23)
- Integrative radiogenomics for virtual biopsy and treatment monitoring in ovarian cancer (2020) (23)
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (22)
- Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-Depleted Murine Embryonic Stem Cells (2010) (22)
- A saltationist theory of cancer evolution (2016) (21)
- Computational identification of cellular networks and pathways. (2007) (20)
- Estimating the predictability of cancer evolution (2019) (20)
- BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes (2016) (19)
- Posterior Association Networks and Functional Modules Inferred from Rich Phenotypes of Gene Perturbations (2012) (17)
- Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival (2017) (16)
- Evolutionary Distances in the Twilight Zone—A Rational Kernel Approach (2010) (16)
- Reconstructing evolving signalling networks by hidden Markov nested effects models (2014) (16)
- Evaluating the effect of perturbations in reconstructing network topologies (2003) (16)
- Multi-parametric and multi-regional histogram analysis of MRI: modality integration reveals imaging phenotypes of glioblastoma (2019) (15)
- Ccube: A fast and robust method for estimating cancer cell fractions (2018) (13)
- SVclone: inferring structural variant cancer cell fraction (2017) (12)
- Ultrasound-guided targeted biopsies of CT-based radiomic tumour habitats: technical development and initial experience in metastatic ovarian cancer (2020) (12)
- Decoding the Interdependence of Multiparametric Magnetic Resonance Imaging to Reveal Patient Subgroups Correlated with Survivals12 (2019) (12)
- Computational diagnostics with gene expression profiles. (2008) (11)
- Genome-wide Estrogen Receptor-α activation is sustained, not cyclical (2018) (11)
- Inferring modulators of genetic interactions with epistatic nested effects models (2017) (11)
- The Genomic Landscape of Early-Stage Ovarian High-Grade Serous Carcinoma (2021) (9)
- GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images (2014) (9)
- Abstract 3000: Pervasive intra-tumour heterogeneity and subclonal selection across cancer types (2018) (9)
- Allele-specific multi-sample copy number segmentation in ASCAT (2020) (8)
- Probabilistic Models for Gene Silencing Data (2006) (8)
- Clinically Interpretable Radiomics-Based Prediction of Histopathologic Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma (2022) (6)
- Non-transcriptional pathway features reconstructed from secondary effects of RNAi (2006) (6)
- Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (2020) (6)
- Publisher Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (2020) (6)
- Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development (2020) (5)
- Absolute copy number fitting from shallow whole genome sequencing data (2021) (5)
- PathML: A unified framework for whole-slide image analysis with deep learning (2021) (5)
- Three-Dimensional Printed Molds for Image-Guided Surgical Biopsies: An Open Source Computational Platform (2020) (5)
- Development of a miRNA‐based classifier for detection of colorectal cancer molecular subtypes (2022) (5)
- Reconstructing gene regulation networks from passive observations and active interventions (2003) (5)
- OncoNEM: inferring tumor evolution from single-cell sequencing data (2016) (5)
- Intra-tumor heterogeneity defines treatment-resistant HER2+ breast tumors (2018) (4)
- A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes (2010) (4)
- Predictive modelling of highly multiplexed tumour tissue images by graph neural networks (2021) (4)
- An introduction to systems genetics (2015) (4)
- Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer (2011) (4)
- Systems genetics: Linking genotypes and phenotypes (2015) (4)
- Data generation and network reconstruction strategies for single cell transcriptomic profiles of CRISPR-mediated gene perturbations. (2019) (3)
- — Molecular Diagnosis — Tumor classification by SVM and PAM (2005) (3)
- Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic reconstruction (2015) (3)
- Deregulation upon DNA damage revealed by joint analysis of context-specific perturbation data (2011) (3)
- Copy number signatures and mutational processes in ovarian carcinoma (2018) (3)
- Class Discovery in Gene Expression Data: Characterizing Splits by Support Vector Machines (2003) (3)
- The integrated genomic and immune landscapes of lethal metastatic breast cancer (MBC). (2018) (3)
- Vignette for RTN : reconstruction of transcriptional networks and analysis of master regulators (2013) (3)
- You Are Not Working for Me; I Am Working with You (2015) (3)
- Allele-specific multi-sample copy number segmentation (2017) (3)
- 3D-printed moulds of renal tumours for image-guided tissue sampling in the clinical setting (2019) (3)
- Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Metaanalysis of transcriptional subtypes (2017) (3)
- Integrated radiogenomics models predict response to neoadjuvant chemotherapy in high grade serous ovarian cancer (2021) (2)
- VULCAN: Network Analysis of ER-α activation reveals reprogramming of GRHL2 (2018) (2)
- Causal modeling dissects tumour-microenvironment interactions in breast cancer (2017) (2)
- A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes (2018) (2)
- Abstract 218: The evolutionary history of 2,658 cancers (2018) (2)
- Estimating cellular pathways from an ensemble of heterogeneous data sources (2014) (2)
- REFINING CELLULAR PATHWAY MODELS USING AN ENSEMBLE OF HETEROGENEOUS DATA SOURCES. (2018) (2)
- 3D-printed moulds for image-guided surgical biopsies: an open source computational platform (2019) (1)
- Yinyin Yuan Complements Genomic Profiling Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors (2012) (1)
- Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig (2020) (1)
- BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes (2017) (1)
- GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images (2014) (1)
- RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations (2012) (1)
- HTSanalyzeR: a R/Bioconductor package for integrated network analysis of high-throughput RNAi screens (2010) (1)
- Novel Quantitative ChIP-seq Methods Measure Absolute Fold-Change in ER Binding Upon Fulvestrant Treatment (2017) (1)
- Statistical discovery of signaling pathways from an ensemble of weakly informative data sources (2007) (1)
- Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (2020) (1)
- The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1 (2017) (1)
- FrenchFISH: Poisson Models for Quantifying DNA Copy Number From Fluorescence In Situ Hybridization of Tissue Sections (2021) (1)
- PLOS Computational Biology 2017 Reviewer and Editorial Board Thank You (2018) (1)
- Intratumoral Heterogeneity of Tumor Infiltration of Glioblastoma Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging (2017) (1)
- High-grade serous ovarian carcinoma organoids as models of chromosomal instability (2022) (1)
- Author Correction: Pan-cancer analysis of whole genomes (2023) (1)
- Scabsolute: Measuring Single-Cell Ploidy and Replication Status (2022) (1)
- VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer (2019) (1)
- Quantification of TFF3 expression from a non-endoscopic device predicts clinically relevant Barrett's oesophagus by machine learning (2022) (1)
- The genomic landscape of recurrent ovarian high grade serous carcinoma: the BriTROC-1 study (2022) (1)
- 11 The heterogeneous genomic and immune landscapes of lethal metastatic breast cancer (2018) (1)
- Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier (2014) (1)
- Inferring structural variant cancer cell fraction (2020) (0)
- How to understand the cell by breaking it – methods and software for network analysis of gene perturbation screens (2010) (0)
- Smoking-dependent expression alterations in nasal epithelium reveal immune impairment linked to germline variation and lung cancer risk (2021) (0)
- In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response (2023) (0)
- Functional analysis of interaction networks (2015) (0)
- Investigating intra-tumour heterogeneity in prostate cancer using structural variation (2015) (0)
- Gene set enrichment and network analyses of high-throughput screens using HTSanalyzeR (2012) (0)
- A composite biomarker for esophageal cancer risk from automated analysis of a non-endoscopic device (2021) (0)
- Signaling pathways from RNAi data (2005) (0)
- Decision letter: A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes (2020) (0)
- AB012. S012. Immunophenotypes of pancreatic ductal adenocarcinoma (2018) (0)
- Abstract IA01: Gene regulatory network approaches to interpreting breast cancer GWAS results (2014) (0)
- Abstract AP09: COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA (2019) (0)
- 1 An introduction to systems genetics (2015) (0)
- Abstract SY38-03: Quantifying tumor heterogeneity in the microenvironment (2016) (0)
- Computational pathology aids derivation of microRNA biomarker signals from Cytosponge samples (2022) (0)
- ecoding the Interdependence of ultiparametric Magnetic esonance Imaging to Reveal atient Subgroups Correlated with urvivals 1 , 2 (2019) (0)
- Phenotype state spaces and strategies for exploring them (2015) (0)
- Author Correction: Inferring structural variant cancer cell fraction (2022) (0)
- Author Correction: Inferring structural variant cancer cell fraction (2022) (0)
- Abstract 476: Predicting response to treatment in early breast cancer using dynamic integrative multi-omic profiling (2022) (0)
- BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies (2015) (0)
- Five selfish reasons to work reproducibly (2015) (0)
- Pleiotropic hierarchies from high-dimensional phenotyping by RNA interference (2006) (0)
- Human Fly Human Target Control Untreated Treated Untreated Treated or Xenogeneic Standard or Internal Standard ChIP-Seq of Target of interest (2017) (0)
- Abstract IA20: Quantifying patterns of tumor evolution (2016) (0)
- Title: KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice (2018) (0)
- Correction to: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer (2019) (0)
- Sa1147 – Analysis of Socio-Economic Factors Affecting the Uptake of the Novel Medical Device Cytosponge (2019) (0)
- CBIO-33INVESTIGATING GLIOMA CELL PHENOTYPES WITH SMALL MOLECULES (2015) (0)
- Author Correction: Patterns of somatic structural variation in human cancer genomes (2020) (0)
- Author Correction: Patterns of somatic structural variation in human cancer genomes (2020) (0)
- D R A F T Integrated radiogenomics models predict response to neoadjuvant chemotherapy in high grade serous ovarian cancer (2021) (0)
- Computational Inference of Cellular Pathways (2005) (0)
- Network analysis of ChIP-seq data by VULCAN identifies GRHL2 as a key co-regulator of ERa in luminal breast cancer (2019) (0)
- Molecular diagnosis, part II (2005) (0)
- COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA (2019) (0)
- Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (0)
- The effect of perturbations in reconstructing network structure (2003) (0)
- ER ChIP-seq on Treatment of Fulvestrant with CTCF Control (2017) (0)
- TMOD-24. PATIENT-DERIVED BRAIN TUMOUR IPSCS: MODELS FOR INVESTIGATING GLIOMA STEMNESS AND DRUG DISCOVERY (2018) (0)
- Joining the dots: network analysis of gene perturbation data (2015) (0)
- Package 'santa' Title Spatial Analysis of Network Associations (2013) (0)
- The small molecule KHS 101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD 1 (2017) (0)
- RADIOMIC FEATURES FROM PHYSIOLOGICAL MRI SHOWS IMPROVED ACCURACY OVER STRUCTURAL MRI IN PREDICTING MGMT PROMOTER METHYLATION IN GLIOBLASTOMA (2018) (0)
- Probabilistic Graphical Models for Cellular Pathways (2005) (0)
- The evolutionary history of 2,658 cancers (2020) (0)
- Clonal expansion index stratifies patients into prognostic subgroups. (2015) (0)
- Vignette for Fletcher 2013 b : master regulators of FGFR 2 signalling and breast cancer risk (2014) (0)
- Gene networks from RNAi data (2004) (0)
- Correction to: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer (2019) (0)
- FrenchFISH: Poisson models for quantifying DNA copy-number from fluorescence in situ hybridisation of tissue sections (2018) (0)
- Deregulation of hydroxybutyric acid metabolism provides diagnostic and prognostic biomarkers in ovarian high-grade serous carcinomas (2016) (0)
- Neutral tumor evolution? (2018) (0)
- PO-329 Rejecting neutral tumour evolution across human cancer types (2018) (0)
- Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development (2020) (0)
- Dynamic network models of protein complexes (2015) (0)
- Predicting response to cytotoxic chemotherapy (2023) (0)
- Neutral tumor evolution? (2018) (0)
- Author Correction: The evolutionary history of 2,658 cancers (2023) (0)
- Author Correction: The evolutionary history of 2,658 cancers (2023) (0)
- A community effort to create standards for evaluating tumor subclonal reconstruction (2020) (0)
- Triage-driven diagnosis for early detection of esophageal cancer using deep learning (2020) (0)
- Vignette for Fletcher2013b: master regulators of FGFR2 signalling and breast cancer risk. (2015) (0)
- ZMIZ1 — A novel Estrogen Receptor co-activator that enhances the growth of ER+ breast cancer (2019) (0)
- Abstract PL05-03: Phylogenetic quantification of intra-tumor heterogeneity predicts time to relapse in high-grade serous ovarian cancer. (2013) (0)
- Vignette for PANR : Posterior association network and enriched functional gene modules inferred from rich phenotypes of gene perturbations (2012) (0)
- Abstract 53: The copy number landscape of early stage ovarian high grade serous carcinoma (2022) (0)
- Abstract 4321: Clinical-grade early detection of esophageal cancer on data from a non-endoscopic device using deep learning (2023) (0)
- Inferring genetic architecture from systems genetics studies (2015) (0)
- Traces of molecular disease mechanisms on microarrays (2005) (0)
- Abstract LB-108: Automated immunohistochemistry-based identification of molecular subtypes in colorectal cancer (2015) (0)
- — Nested Effects Models — An example in Drosophila immune response (2006) (0)
- Multi-Parametric and Multi-Regional Histogram Analysis of MRI: Revealing Imaging Phenotypes of Glioblastoma Correlated with Patient Survival (2017) (0)
- Title : KHS 101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice (2018) (0)
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What Schools Are Affiliated With Florian Markowetz?
Florian Markowetz is affiliated with the following schools:
