Folkert Kuipers

Q: What Schools Are Affiliated With Folkert Kuipers

Folkert Kuipers is affiliated with the following schools: University of Amsterdam, Kanazawa University, University of British Columbia, University of Groningen, Leiden University

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Folkert Kuipers

Philosophy

#6086

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#9058

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#3278

World Rank

#4409

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Philosophy

Folkert Kuipers's Degrees

PhD Medicine University of Amsterdam
Doctorate Medicine University of Amsterdam

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Folkert Kuipers's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Role of bile acids and bile acid receptors in metabolic regulation. (2009) (1386)
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria (2002) (817)
The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice* (2006) (517)
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. (2006) (505)
Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles* (2002) (494)
The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity* (2006) (414)
Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. (1999) (407)
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. (1995) (401)
The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. (2005) (343)
Beyond intestinal soap—bile acids in metabolic control (2014) (336)
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. (2002) (317)
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction (2019) (311)
Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity (2007) (306)
Hepatic steatosis: a mediator of the metabolic syndrome. Lessons from animal models. (2004) (271)
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity (2011) (267)
Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion. (2000) (262)
Increased Hepatobiliary and Fecal Cholesterol Excretion upon Activation of the Liver X Receptor Is Independent of ABCA1* (2002) (244)
Glucose regulates the expression of the farnesoid X receptor in liver. (2004) (242)
Differential Effects of Scavenger Receptor BI Deficiency on Lipid Metabolism in Cells of the Arterial Wall and in the Liver* (2003) (234)
Enterohepatic circulation in the rat. (1985) (225)
Activation of the Liver X Receptor Stimulates Trans-intestinal Excretion of Plasma Cholesterol* (2009) (224)
The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition* (2005) (224)
24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux* (2006) (224)
Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice (2003) (223)
Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome (2010) (221)
Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice (2006) (208)
Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. (2007) (207)
Fibrates Suppress Bile Acid Synthesis via Peroxisome Proliferator–Activated Receptor-&agr;–Mediated Downregulation of Cholesterol 7&agr;-Hydroxylase and Sterol 27-Hydroxylase Expression (2001) (205)
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. (2003) (197)
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. (2005) (196)
Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. (2008) (193)
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. (2005) (184)
Dietary fat content alters insulin-mediated glucose metabolism in healthy men. (2001) (179)
Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism (2010) (178)
Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes. (1997) (172)
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. (2003) (166)
High Fat Feeding Induces Hepatic Fatty Acid Elongation in Mice (2009) (159)
Proprotein Convertase Subtilisin Kexin Type 9 Null Mice Are Protected From Postprandial Triglyceridemia (2009) (157)
Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. (2004) (153)
A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis (2018) (152)
Fenofibrate Simultaneously Induces Hepatic Fatty Acid Oxidation, Synthesis, and Elongation in Mice* (2009) (149)
Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. (1997) (146)
Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. (1988) (144)
Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. (2005) (142)
Emerging roles of the intestine in control of cholesterol metabolism. (2006) (138)
Bile Acid Sequestrants and the Treatment of Type 2 Diabetes Mellitus (2012) (133)
Apolipoprotein E Participates in the Regulation of Very Low Density Lipoprotein-Triglyceride Secretion by the Liver* (1999) (133)
Liver X receptor activation restores memory in aged AD mice without reducing amyloid (2011) (132)
Increased epithelial cell proliferation in the colon of patients with acromegaly. (1996) (131)
The Liver X‐Receptor (LXR) gene promoter is hypermethylated in a mouse model of prenatal protein restriction (2009) (130)
Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia (2011) (128)
Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate, and bile acids. (1990) (127)
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL (2001) (124)
Regulation of direct transintestinal cholesterol excretion in mice. (2008) (123)
Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. (1991) (115)
Tissue-Specific Induction of Intestinal ABCA1 Expression With a Liver X Receptor Agonist Raises Plasma HDL Cholesterol Levels (2006) (114)
Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk. (2019) (113)
Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. (2017) (110)
Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. (2003) (108)
Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice. (1998) (108)
Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation. (2004) (108)
Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures. (2009) (107)
Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture (1995) (107)
Peroxisome Proliferator–Activated Receptor α Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets (2006) (106)
A Role of the Bile Salt Receptor FXR in Atherosclerosis (2010) (103)
ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance. (2007) (102)
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. (2003) (102)
New insights into the mechanism of bile acid—induced biliary lipid secretion (1995) (101)
Altered lipid metabolism in apolipoprotein E–deficient mice does not affect cholesterol balance across the liver (1996) (101)
Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation (1997) (100)
Acute Inhibition of Hepatic Glucose-6-phosphatase Does Not Affect Gluconeogenesis but Directs Gluconeogenic Flux toward Glycogen in Fasted Rats (2001) (99)
Pharmacomicrobiomics: a novel route towards personalized medicine? (2018) (99)
The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse. (2005) (99)
Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. (1997) (99)
Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter. (2006) (98)
Dietary plant sterols accumulate in the brain. (2006) (97)
Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor– and liver X receptorα–controlled metabolic pathways in mice (2010) (97)
Biliary fibrosis associated with altered bile composition in a mouse model of erythropoietic protoporphyria. (1999) (95)
Reverse Cholesterol Transport Revisited: Contribution of Biliary Versus Intestinal Cholesterol Excretion (2011) (95)
Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats (1999) (95)
The effects of carbohydrate variation in isocaloric diets on glycogenolysis and gluconeogenesis in healthy men. (2000) (93)
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP‐binding cassette transporter g5/g8 in mice (2009) (92)
Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. (2003) (92)
CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500112-JLR200 (2005) (91)
Localization of the Wilson's disease protein in human liver. (1999) (91)
Transient impairment of the adaptive response to fasting in FXR‐deficient mice (2005) (90)
Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux (2009) (87)
Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4. (2015) (87)
Non‐alcoholic fatty liver disease is associated with cardiovascular disease risk markers (2009) (82)
Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation. (2000) (82)
Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice (2010) (82)
HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes. (2005) (81)
Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status (1999) (80)
Quantification of hepatic carbohydrate metabolism in conscious mice using serial blood and urine spots. (2003) (80)
Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E. (2001) (79)
Differential effects of streptozotocin-induced diabetes on expression of hepatic ABC-transporters in rats. (2002) (79)
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control (2007) (78)
Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats. (2001) (78)
Increased de novo Lipogenesis and Delayed Conversion of Large VLDL into Intermediate Density Lipoprotein Particles Contribute to Hyperlipidemia in Glycogen Storage Disease Type 1a (2008) (77)
The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design. (2010) (77)
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL. (2001) (77)
Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids[S] (2017) (76)
Plasma bile acids are not associated with energy metabolism in humans (2010) (76)
Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase. (1986) (75)
Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. (2006) (75)
Measurement of parameters of cholic acid kinetics in plasma using a microscale stable isotope dilution technique: application to rodents and humans. (2001) (75)
Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production. (2005) (74)
A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice (2011) (74)
The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways* (2010) (73)
Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats. (1991) (69)
Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice. (2011) (68)
Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome (2018) (68)
Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice. (2000) (67)
The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia (2006) (67)
A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S] (2019) (67)
Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. (2006) (67)
Randomized, double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary nonpolyposis colorectal cancer. (1995) (66)
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine. (2000) (66)
The ins and outs of reverse cholesterol transport (2004) (66)
Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. (2002) (65)
The uncoupling of biliary lipid from bile acid secretion by organic anions in the rat. (1990) (64)
Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity (2020) (63)
A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. (2008) (62)
Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes (2003) (62)
An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption in Fxr–/– Mice* (2009) (61)
Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia. (1989) (61)
Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women. (2009) (61)
Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diets⃞ Published, JLR Papers in Press, September 28, 2006. (2006) (61)
Ritonavir Impairs Lipoprotein Lipase–Mediated Lipolysis and Decreases Uptake of Fatty Acids in Adipose Tissue (2006) (61)
Differential effects of nitric oxide synthase inhibitors on endotoxin- induced liver damage in rats (1997) (60)
Disturbed lipid metabolism in glycogen storage disease type 1 (2002) (60)
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice (2006) (60)
ATP binding cassette transporter gene expression in rat liver progenitor cells (2003) (59)
Low-fat, high-carbohydrate and high-fat, low-carbohydrate diets decrease primary bile acid synthesis in humans. (2004) (59)
The Farnesoid X Receptor (FXR) as Modulator of Bile Acid Metabolism (2004) (59)
Induction of Mdr1b expression by tumor necrosis factor‐α in rat liver cells is independent of p53 but requires NF‐κB signaling (2001) (58)
In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein (2004) (57)
Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats. (2005) (56)
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. (1999) (56)
Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty acid oxidation defects. (2013) (56)
A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice (2013) (55)
Acyl‐coenzyme A: Cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7α‐hydroxylase in cultured rat hepatocytes and in vivo in the rat (1999) (55)
The farnesoid X receptor (2004) (55)
Gall bladder dysmotility: a risk factor for gall stone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil (2003) (55)
The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism (2012) (53)
New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition (2015) (53)
Cholesterol transport by the placenta: placental liver X receptor activity as a modulator of fetal cholesterol metabolism? (2007) (52)
Hepatic de Novo Synthesis of Glucose 6-Phosphate Is Not Affected in Peroxisome Proliferator-activated Receptor α-Deficient Mice but Is Preferentially Directed toward Hepatic Glycogen Stores after a Short Term Fast* (2004) (52)
Liver receptor homolog‐1 is critical for adequate up‐regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration (2011) (52)
Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo (2010) (51)
Bile secretion of cadmium, silver, zinc and copper in the rat. Involvement of various transport systems. (1996) (50)
Liver pathology and hepatocarcinogenesis in a long‐term mouse model of erythropoietic protoporphyria (2003) (50)
The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia? (2010) (49)
Two pathways for biliary copper excretion in the rat: The role of glutathione (1990) (48)
Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice1[S] (2009) (47)
Bile acids suppress the secretion of very‐low‐density lipoprotein by human hepatocytes in primary culture (1995) (46)
Farnesoid X receptor: a new player in glucose metabolism? (2005) (46)
Extracorporal albumin dialysis (MARS) improves cholestasis and normalizes low apo A-I levels in a patient with benign recurrent intrahepatic cholestasis (BRIC). (2002) (46)
A low-carbohydrate/high-fat diet improves glucoregulation in type 2 diabetes mellitus by reducing postabsorptive glycogenolysis. (2004) (46)
Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles. (2005) (46)
New insights in the multiple roles of bile acids and their signaling pathways in metabolic control (2018) (45)
Increased lipogenesis and resistance of lipoproteins to oxidative modification in two patients with glycogen storage disease type 1a. (2002) (45)
Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex (2012) (45)
Benign recurrent intrahepatic cholestasis: altered bile acid metabolism. (1989) (44)
Adenosine triphosphate-dependent copper transport in isolated rat liver plasma membranes. (1995) (44)
Hyperlipidemia and atherosclerosis associated with liver disease in ferrochelatase-deficient mice. (1999) (44)
The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice. (2004) (43)
Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes. (1995) (43)
Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion (2018) (43)
The farnesoid X receptor: a novel drug target? (2004) (43)
Disturbed hepatic carbohydrate management during high metabolic demand in medium‐chain acyl–CoA dehydrogenase (MCAD)–deficient mice (2008) (42)
Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation (2001) (42)
Cyclosporine A–Induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation (2004) (41)
Soraphen, an inhibitor of the acetyl‐CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high‐fat diet (2009) (41)
Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats. (1994) (41)
Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions. (1991) (41)
Impaired activity of the bile canalicular organic anion transporter (Mrp2/cmoat) is not the main cause of ethinylestradiol‐induced cholestasis in the rat (1998) (41)
Treatment of EFA deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis. (2004) (40)
Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. (2010) (40)
Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation. (1998) (40)
Activation of liver X receptor-α reduces activation of the renal and cardiac renin–angiotensin–aldosterone system (2010) (40)
Lipoproteins and liposomes as in vivo cholesterol vehicles in the rat: preferential use of cholesterol carried by small unilamellar liposomes for the formation of muricholic acids. (1986) (40)
Plant Sterols Cause Macrothrombocytopenia in a Mouse Model of Sitosterolemia* (2008) (40)
Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling. (2001) (39)
Modulation of pharmacokinetic behavior of liposomes (1997) (39)
Lxrα Deficiency Hampers the Hepatic Adaptive Response to Fasting in Mice* (2008) (39)
Isolation and characterization of canalicular and basolateral plasma membrane fractions from human liver. (1991) (39)
Gene expression profiling in livers of mice after acute inhibition of beta-oxidation. (2007) (39)
Exercise enhances whole-body cholesterol turnover in mice. (2009) (39)
Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat. (1999) (38)
Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver. (2007) (38)
Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content. (2020) (38)
Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. (2000) (37)
Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol. (2012) (37)
Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. (1999) (37)
Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞ Published, JLR Papers in Press, November 4, 2006. (2007) (37)
Contribution of newly synthesized cholesterol to rat plasma and bile determined by mass isotopomer distribution analysis: bile-salt flux promotes secretion of newly synthesized cholesterol into bile. (1998) (37)
Evidence for reverse cholesterol transport in vivo from liver endothelial cells to parenchymal cells and bile by high-density lipoprotein. (1990) (37)
FXR‐deficiency confers increased susceptibility to torpor (2007) (37)
Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes. (1992) (37)
Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1. (2010) (36)
The ABC of hepatic and intestinal cholesterol transport. (2005) (36)
Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice (2008) (36)
Human apolipoprotein C-I expression in mice impairs learning and memory functions Published, JLR Papers in Press, December 26, 2007. (2008) (36)
Dietary carbohydrate deprivation increases 24-hour nitrogen excretion without affecting postabsorptive hepatic or whole body protein metabolism in healthy men. (2003) (36)
Hepatic glucose production is more sensitive to insulin-mediated inhibition than hepatic VLDL-triglyceride production. (2006) (35)
Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice. (1999) (35)
Benign recurrent intrahepatic cholestasis: A long‐term follow‐up study of two patients (1989) (35)
Selective expression of cholesterol metabolism genes in normal CD34+CD38- cells with a heterogeneous expression pattern in AML cells. (2006) (35)
Cyclosporin A and Enterohepatic Circulation of Bile Salts in Rats: Decreased Cholate Synthesis but Increased Intestinal Reabsorption (2003) (35)
Short- and long-term effects of biliary drainage on hepatic cholesterol metabolism in the rat. (1990) (34)
[Bile formation and cholestasis]. (2000) (34)
Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet. (2009) (33)
FXR: the key to benefits in bariatric surgery? (2014) (33)
Cerebral Accumulation of Dietary Derivable Plant Sterols does not Interfere with Memory and Anxiety Related Behavior in Abcg5−/− Mice (2011) (33)
Scavenger receptor BI facilitates hepatic very low density lipoprotein production in mice (2010) (32)
Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice (2010) (32)
Cross-talk between liver and intestine in control of cholesterol and energy homeostasis. (2014) (32)
Characterization of the inhibitory effects of bile acids on very-low-density lipoprotein secretion by rat hepatocytes in primary culture. (1996) (32)
Mechanisms and (patho)physiological significance of biliary cholesterol secretion. (1997) (32)
Selected Nutrients and Their Implications for Health and Disease across the Lifespan: A Roadmap (2014) (32)
Mechanism of bile acid-induced biliary lipid secretion in the rat: effect of conjugated bilirubin. (1993) (32)
Gut microbiome and bile acids in obesity-related diseases. (2021) (32)
Hepatic processing of the cholesteryl ester from low density lipoprotein in the rat. (1986) (32)
Hepatic expression of ABC transporters G5 and G8 does not correlate with biliary cholesterol secretion in liver transplant patients (2005) (32)
Different pathways of canalicular secretion of sulfated and non-sulfated fluorescent bile acids: a study in isolated hepatocyte couplets and TR- rats. (1999) (32)
Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes. (2001) (32)
Detection of impaired intestinal absorption of long-chain fatty acids: validation studies of a novel test in a rat model of fat malabsorption. (2000) (32)
Effects of oral calcium supplementation on intestinal bile acids and cytolytic activity of fecal water in patients with adenomatous polyps of the colon (1993) (31)
Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia. (2006) (31)
Voluntary exercise increases cholesterol efflux but not macrophage reverse cholesterol transport in vivo in mice (2010) (30)
Enterohepatic circulation in man. A simple method for the determination of duodenal bile acids. (1986) (30)
Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice[S] (2013) (30)
BILE ACIDS AND THE HEPATOBILIARY SYSTEM (1993) (29)
EFFECTS OF CYCLOSPORINE A (CSA) ON LDL-RECEPTOR ACTIVITY AND BILE-ACID SYNTHESIS IN HEPATOCYTE MONOLAYER-CULTURES AND INVIVO IN RAT (1987) (29)
The unique acyl chain specificity of biliary phosphatidylcholines in mice is independent of their biosynthetic origin in the liver (1999) (29)
Hepatic lipid accumulation, altered very low density lipoprotein formation and apolipoprotein E deposition in apolipoprotein E3-Leiden transgenic mice. (2000) (29)
Nutrient Status Assessment in Individuals and Populations for Healthy Aging—Statement from an Expert Workshop (2015) (29)
Role of bile acids in inflammatory liver diseases (2021) (29)
Biliary lipid secretion in the rat. The uncoupling of biliary cholesterol and phospholipid secretion from bile acid secretion by sulfated glycolithocholic acid. (1987) (28)
Prednisolone increases enterohepatic cycling of bile acids by induction of Asbt and promotes reverse cholesterol transport. (2014) (28)
Org 214007-0: A Novel Non-Steroidal Selective Glucocorticoid Receptor Modulator with Full Anti-Inflammatory Properties and Improved Therapeutic Index (2012) (28)
Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice (2004) (28)
Mechanism of biliary lipid secretion in the rat: A role for bile acid–independent bile flow? (1993) (27)
Combining Simvastatin with the Farnesyltransferase Inhibitor Tipifarnib Results in an Enhanced Cytotoxic Effect in a Subset of Primary CD34+ Acute Myeloid Leukemia Samples (2009) (27)
Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer proteins⃞ Published, JLR Papers in Press, October 19, 2006. (2007) (27)
Rosuvastatin Reduces Plasma Lipids by Inhibiting VLDL Production and Enhancing Hepatobiliary Lipid Excretion in ApoE*3-Leiden Mice (2005) (26)
Validation in an animal model of the carbon 13-labeled mixed triglyceride breath test for the detection of intestinal fat malabsorption. (1999) (26)
Hypothalamically-induced insulin release and its potentiation during oral and intravenous glucose loads (1984) (26)
Low retinol levels differentially modulate bile salt–induced expression of human and mouse hepatic bile salt transporters (2009) (26)
Macrophage ABCG 1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice (2006) (25)
Fat Absorption and Lipid Metabolism in Cholestasis (2013) (25)
Dexamethasone Exposure of Neonatal Rats Modulates Biliary Lipid Secretion and Hepatic Expression of Genes Controlling Bile Acid Metabolism in Adulthood Without Interfering With Primary Bile Acid Kinetics (2008) (25)
Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant). (1992) (25)
Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice (2014) (25)
Hepatic bile salt flux does not modulate level and activity of the sinusoidal Na+-taurocholate cotransporter (ntcp) in rats. (1997) (25)
Relationship between biliary lipid and protoporphyrin secretion; potential role of mdr2 P-glycoprotein in hepatobiliary organic anion transport. (1996) (25)
Fat malabsorption in essential fatty acid-deficient mice is not due to impaired bile formation (2002) (24)
Transintestinal and Biliary Cholesterol Secretion Both Contribute to Macrophage Reverse Cholesterol Transport in Rats—Brief Report (2017) (24)
Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice. (2006) (23)
Cholangiopathy and Biliary Fibrosis in Cyp2c70-Deficient Mice Are Fully Reversed by Ursodeoxycholic Acid (2020) (23)
Administration of phosphatidylcholine-cholesterol liposomes partially reconstitutes fat absorption in chronically bile-diverted rats. (2004) (23)
Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice. (2010) (23)
Bile Acid Sequestration Reduces Plasma Glucose Levels in db/db Mice by Increasing Its Metabolic Clearance Rate (2011) (23)
A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation (2015) (23)
Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis[S] (2018) (22)
The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion Published, JLR Papers in Press, June 26, 2007. (2007) (22)
Mdr P‐glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin‐induced mouse model of erythropoietic protoporphyria (2002) (22)
The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance. (2019) (22)
Bile Secretion of Trace Elements in Rats with a Congenital Defect in Hepatobiliary Transport of Glutathione (1990) (22)
The contribution of newly synthesized cholesterol to bile salt synthesis in rats quantified by mass isotopomer distribution analysis. (2000) (21)
Characterization of gut microbial structural variations as determinants of human bile acid metabolism (2021) (21)
Biliary secretion of trace elements and minerals in the rat. Effects of bile flow variation and diurnal rhythms. (1991) (21)
Feeding and temperature responses to intravenous leptin infusion are differential predictors of obesity in rats. (2004) (21)
Mice Expressing Only the Mutant APOE3Leiden Gene Show Impaired VLDL Secretion (2001) (20)
Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice (2019) (20)
Reduced cholesterol absorption upon PPARδ activation coincides with decreased intestinal expression of NPC1L1 Published, JLR Papers in Press, December 16, 2004. DOI 10.1194/jlr.M400400-JLR200 (2005) (20)
High Frequency of a Retinoid X Receptor &ggr; Gene Variant in Familial Combined Hyperlipidemia That Associates With Atherogenic Dyslipidemia (2007) (20)
Differential hepatic processing and biliary secretion of head-group and acyl chains of liposomal phosphatidylcholines. (1991) (20)
Acute effects of pentobarbital-anaesthesia on bile secretion. (1985) (20)
How does copper get into bile? New insights into the mechanism(s) of hepatobiliary copper transport. (1996) (20)
Differences in hepatic processing of dietary and intravenously administered copper in rats (1997) (19)
Apolipoprotein CI knock-out mice display impaired memory functions. (2011) (19)
Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism. (2008) (19)
Effects of dietary cholesterol on bile formation and hepatic processing of chylomicron remnant cholesterol in the rat (1993) (19)
The effect of carbohydrate and fat variation in euenergetic diets on postabsorptive free fatty acid release. (2002) (19)
Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis. (2009) (18)
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development (2019) (18)
Clofibrate improves glucose tolerance in fat-fed rats but decreases hepatic glucose consumption capacity. (2002) (18)
Bile acid sequestration normalizes plasma cholesterol and reduces atherosclerosis in hypercholesterolemic mice. No additional effect of physical activity. (2013) (18)
Cholestasis induced by sulphated glycolithocholic acid in the rat: protection by endogenous bile acids. (1985) (18)
Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. (1999) (18)
Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice (2004) (18)
Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretions⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of two figures. Published, JLR Papers in Press, November 25, 2007. (2008) (18)
Stereoselectivity of glutathione conjugation: blood elimination of alpha-bromoisovalerylurea enantiomers and biliary excretion of the conjugates in unanesthetized normal or congenitally jaundiced rats. (1989) (17)
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome (2022) (17)
Determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates by means of stable isotope dilution technique, making use of deuterated cholic acid and chenodeoxycholic acid. (1988) (17)
Adenosine triphosphate-dependent copper transport in human liver. (1996) (17)
Cholesterol Synthesis and De Novo Lipogenesis in Premature Infants Determined by Mass Isotopomer Distribution Analysis (2002) (17)
Fat malabsorption in essential fatty acid-deficient mice is not due to impaired bile formation. (1999) (17)
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis (2021) (17)
Metabolic responses to long-term pharmacological inhibition of CB1-receptor activity in mice in relation to dietary fat composition (2010) (16)
Intestinal absorption of lithocholic acid sulfates in the rat: inhibitory effects of calcium. (1986) (16)
Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification. (2020) (16)
FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements[S] (2019) (16)
Excessive Portal Venous Supply of Long‐Chain Free Fatty Acids to the Liver, Leading to Hypothalamus‐Pituitary‐Adrenal‐Axis and Sympathetic Activation as a Key to the Development of Syndrome X: A Proposed Concept for the Induction of Syndrome X (1999) (15)
Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients. (2012) (15)
Two pathways for biliary copper excretion in the rat. The role of glutathione. (1989) (15)
Postnatal Treatment With Dexamethasone Perturbs Hepatic and Cardiac Energy Metabolism and Is Associated With a Sustained Atherogenic Plasma Lipid Profile in Suckling Rats (2007) (15)
Cholestasis and the interactions of sulfated glyco- and taurolithocholate with calcium. (1988) (15)
Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia. (2009) (15)
Acute inhibition of hepatic beta-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity. (2005) (15)
Impaired chylomicron formation in mdr2 P-glycoprotein-deficient mice lacking biliary lipid secretion (1998) (15)
Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice. (2009) (15)
Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice (2019) (14)
Heterogeneity in simvastatin-induced cytotoxicity in AML is caused by differences in Ras-isoprenylation (2012) (14)
ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota. (2017) (14)
The role of transhepatic bile salt flux in the control of hepatic secretion of triacylglycerol-rich lipoproteins in vivo in rodents. (2002) (14)
Hepatic ChREBP activation limits NAFLD development in a mouse model for Glycogen Storage Disease type Ia. (2020) (14)
Molecular Link Between Bile Acid and Lipid and Glucose Metabolism (2005) (13)
Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance. (2012) (13)
Changes in rectal epithelial cell proliferation and intestinal bile acids after subtotal colectomy in familial adenomatous polyposis. (1992) (13)
Emerging roles of bile acids in control of intestinal functions. (2020) (13)
Treatment of patients with benign recurrent intrahepatic cholestasis (1989) (13)
Neonatal dexamethasone administration causes progressive renal damage due to induction of an early inflammatory response. (2008) (13)
Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. (2005) (13)
Processing of the phospholipid analogue phosphatidyl(N-sulphorhodamine B sulphonyl)ethanolamine by rat hepatocytes in vitro and in vivo. (1992) (13)
Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a (2020) (13)
One-step solvolysis of 3-, 7- and 12-sulfated free and conjugated bile acids. (1990) (12)
Altered bile acid kinetics contribute to postprandial hypoglycaemia after Roux-en-Y gastric bypass surgery (2021) (12)
Effect of infusion of "tris-galactosyl-cholesterol" on plasma cholesterol, clearance of lipoprotein cholesteryl esters, and biliary secretion in the rat. (1987) (12)
Variability in responsiveness to lovastatin of the primitive CD34+ AML subfraction compared to normal CD34+ cells (2009) (12)
Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease. (2019) (12)
Liposomes in vivo; conversion of liposomal cholesterol to bile salts. (1987) (11)
Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes. (2007) (11)
University of Groningen Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha (2007) (11)
Variability of human hepatic UDP-glucuronosyltransferase activity. (1999) (11)
Assessment of modes of action and efficacy of plasma cholesterol-lowering drugs: measurement of cholesterol absorption, cholesterol synthesis and bile acid synthesis and turnover using novel stable isotope techniques. (2005) (11)
SEPARATE TRANSPORT MECHANISMS FOR BILIARY-EXCRETION OF SULFATED AND UNSULFATED BILE-ACIDS IN THE RAT (1987) (11)
Sulphated lithocholic acid conjugates in serum from children with hepatic and intestinal diseases. (1985) (11)
Bile duct proliferation associated with bile salt‐induced hypercholeresis in Mdr2 P‐glycoprotein‐deficient mice (2005) (10)
Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis (2021) (10)
Developments in bile acid kinetic measurements using 13C and 2H: 105 times improved sensitivity during the last 40 years (2009) (10)
Characterization of human liver microsomal UDP-glycosyltransferases using photoaffinity analogs. (1995) (10)
Processing of cholesteryl ester from low-density lipoproteins in the rat. Hepatic metabolism and biliary secretion after uptake by different hepatic cell types. (1989) (10)
Effects of dietary corn and olive oil versus coconut fat on biliary cholesterol secretion in rats. (1994) (10)
Intestinal capacity to digest and absorb carbohydrates is maintained in a rat model of cholestasis. (2007) (10)
Disturbed lipid metabolism in glycogen storage disease type 1 (2007) (10)
Effects of hemicolectomy on bile acid metabolism in relation to colon carcinogenesis in man (1997) (10)
Lipid Trafficking in Hepatocytes: Relevance to Biliary Lipid Secretion (1994) (10)
Modulation of Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles (2021) (10)
Cholecystectomy increases the risk of dumping syndrome and postbariatric hypoglycemia after bariatric surgery. (2020) (10)
Bile acid look-alike controls life span in C. elegans. (2013) (9)
Delivery of liposome-associated drugs to liver cells. (1987) (9)
The Origin of Follicular Bile Acids in the Human Ovary. (2019) (9)
Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study (2020) (9)
Interactions between organic anions, micelles and vesicles in model bile systems. (1996) (9)
Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients (2019) (8)
Metabolism of steroids: the removal of exogenous 17-hydroxycorticosterone from the peripheral circulation in dogs. (1958) (8)
The role of glutathione in bile secretion of endogenous trace elements in rats. (1993) (8)
Inhibition of apolipoprotein B secretion by taurocholate is controlled by the N-terminal end of the protein in rat hepatoma McArdle-RH7777 cells. (2003) (8)
In vivo determination of very-low-density lipoprotein-apolipoprotein B100 secretion rates in humans with a low dose of l-[1-13C]valine and isotope ratio mass spectrometry. (1998) (8)
Impaired VLDL catabolism links hypoglycemia to hypertriglyceridemia in GSD Ia. (2021) (7)
Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice. (2001) (7)
Downregulation of hepatic and intestinal ATP-binding-cassette transporters abcg5 and abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes (2003) (7)
The Effects of Intrauterine Malnutrition on Maternal-Fetal Cholesterol Transport and Fetal Lipid Synthesis in Mice (2010) (7)
Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet (2019) (7)
24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer’s Disease (2021) (7)
Hepatic SR-BI but not endothelial lipase ( EL ) expression determines biliary cholesterol secretion in mice (2009) (7)
University of Groningen 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors ( statins ) induce hepatic expression of the phospholipid translocase mdr 2 in rats (1999) (7)
The canalicular bile salt exporting protein BSEP is not expressed in patients with progressive familial intrahepatic cholestasis type 2. (1998) (7)
Copper-induced apical trafficking of ATP7B in polarized cells provides a mechanism for biliary copper excretion. (2000) (7)
Mechanism of biliary lipid secretion (1995) (7)
Treatment of essential fatty acid deficiency with dietary triglycerides or phospholipids in a murine model of extrahepatic cholestasis6 (2003) (7)
LOWERING PLASMA-CHOLESTEROL IN THE RAT BY INFUSION OF A TRIS-GALACTOSIDE-TERMINATED CHOLESTEROL DERIVATIVE (1987) (6)
Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet (2019) (6)
Localization and regulation of a novel canalicular ABC-transporter. (1996) (6)
Dietary cholesterol-induced down-regulation of intestinal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity is diminished in rabbits with hyperresponse of serum cholesterol to dietary cholesterol. (1993) (6)
Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase (2021) (5)
Chapter 4 CD 36 Deficiency in Mice Impairs Lipoprotein Lipase-Mediated Triglyceride Clearance (2006) (5)
Inhibition and induction of bile acid synthesis by ketoconazole effects on bile formation in the rat (1989) (5)
Short-term obeticholic acid treatment does not impact cholangiopathy in Cyp2c70-deficient mice with a human-like bile acid composition. (2022) (5)
The effects of intrauterine malnutrition on maternal-fetal cholesterol transport and fetal lipid synthesis in mice. (2010) (5)
Gut-microbe derived TMAO and its association with more progressed forms of AF: Results from the AF-RISK study (2021) (5)
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich VLDL particles (2002) (5)
Evaluation and clinical application of the Enterotest for the determination of human biliary porphyrin composition. (1995) (5)
BILE ACID-INDUCED BILIARY LIPID SECRETION IS TRIGGERED BY BILE-ACIDS IN THE CANALICULAR LUMEN (1990) (5)
Induction of Mdr 1 b Expression by Tumor Necrosis Factor-in Rat Liver Cells Is Independent of p 53 but Requires NF-B Signaling (2001) (5)
Low production of 12α-hydroxylated bile acids prevents hepatic steatosis in Cyp2c70−/− mice by reducing fat absorption (2021) (4)
An unexpected role for bile acid synthesis in adaptation to low temperature (2017) (4)
A novel C-13-linoleic acid absorption test detects lipid malabsorption due to impaired solubilization in rats. (1997) (4)
Conversion of liposomal 5-fluoro-2′-deoxyuridine and its dipalmitoyl derivative to bile acid conjugates of α-fluoro-β-alanine and their excretion into rat bile (1993) (4)
Hyperinsulinemia is Highly Associated with Markers of Hepatocytic Senescence in Two Independent Cohorts. (2022) (4)
Induction of MDR2 P-glycoprotein (PGP) by fibrates is mediated by peroxisome proliferator-activated receptor alpha (PPARα) in the mouse (2000) (4)
Dietary lipid structure in early life does not program fat absorption in later life (2018) (4)
Impaired Very‐Low‐Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia (2021) (4)
Adiponectin levels correlate with the severity of hypertriglyceridaemia in glycogen storage disease Ia (2009) (3)
Fish oil-induced changes in hepatic processing of cholesterol and bile acid synthesis in the rat (1990) (3)
CHAPTER 2 Reduced cholesterol absorption upon PPAR activation coincides with decreased intestinal expression of NPC 1 L 1 (2017) (3)
An early-life diet containing large phospholipid-coated lipid globules programmes later-life postabsorptive lipid trafficking in high-fat diet- but not in low-fat diet-fed mice (2020) (3)
ABCA1-dependent but Apo-A-I-independent cholesterol and phosphatidylcholine efflux mediated by FABAC. (2002) (3)
Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes. (2007) (3)
Two time-point assessment of bile acid kinetics in humans using stable isotopes (2010) (3)
Induction of hepatic mdr2 expression by cholesterol synthesis inhibitors (statins) is mediated via SERBPs (1999) (3)
Chipping away at gallstones (2008) (3)
Effects of dietary fish oil on hepatic cholesterol metabolism. (1992) (3)
Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice (2020) (3)
Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function (2011) (3)
The SPGP gene, encoding the canalicular bile acid transporting protein SPGP/cBST, is not expressed in a subgroup of patients with progressive familial intrahepatic cholestasis (PFIC-2) (1998) (3)
Pipelines and Systems for Threshold-Avoiding Quantification of LC–MS/MS Data (2021) (3)
DIFFERENT CHOLESTEROL PRECURSOR POOLS FOR BILE-ACID SYNTHESIS IN THE RAT (1988) (3)
Biliary secretion of anionic polypeptide fraction is not coupled to that of phospholipids and cholesterol in rats (1997) (3)
Bile secretion of sulfated glycolithocholic acid is required for its cholestatic action in rats. (1992) (3)
Intestinal ABCA1 is a significant contributor to plasma HDL-C and apoB levels in vivo (2005) (3)
Ablation of liver Fxr results in an increased colonic mucus barrier in mice (2021) (3)
BENIGN RECURRENT INTRA-HEPATIC CHOLESTASIS - AN INDICATION FOR AN INTESTINAL DEFECT (1982) (3)
Bile secretion of cadmium, silver, zinc and copper. Involvement of various transport systems in hepatobiliary removal of mono- and divalent metals in the rat. (1996) (2)
REDUCTION OF BILIARY GLUTATHIONE SECRETION BY LOW-DOSES OF SULFATED AND GLUCURONIDATED LITHOCHOLIC ACID IN RATS (1988) (2)
DEFECTIVE BILE SECRETION OF BILE ACID-3-O-GLUCURONIDES IN RATS WITH HEREDITARY CONJUGATED HYPERBILIRUBINEMIA - IMPLICATIONS FOR THE MECHANISM OF LITHOCHOLATE-GLUCURONIDE INDUCED CHOLESTASIS (1988) (2)
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet (2020) (2)
Ritonavir Impairs LPL-mediated Lipolysis And Decreases Uptake of Fatty Acids in Adipose Tissue (2006) (2)
Tu-W28:5 Lack of association of plasma phytosterols with risk of coronary heart disease in the cora-study (2006) (2)
Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans (2022) (2)
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia (2021) (2)
Systems genetics approach reveals cross-talk between bile acids and intestinal microbes (2019) (2)
Enteral administration of phosphatidylcholine-cholesterol liposomes partially overcomes intestinal fat malabsorption in bile-deficient rats. (2000) (2)
SULFATED GLYCOLITHOCHOLIC ACID-INDUCED CHOLESTASIS - THE ROLE OF THE ENTEROHEPATIC CIRCULATION (EHC) (1984) (2)
Impaired production of very low density lipoproteins (VLDL) by apolipoprotein E-deficient mouse hepatocytes in primary culture (1996) (2)
Low retinol levels potentiate bile acid-induced expression of the bile salt export pump in vitro and in vivo. (2004) (2)
CHOLESTATIC LIVER DISEASES: NEW STRATEGIES FOR PREVENTION AND TREATMENT OF HEPATOBILIARY AND CHOLESTATIC LIVER DISEASES (1994) (2)
ERRATUM The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse (vol 328, pg 57, 2005) (2005) (2)
Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism (2022) (2)
Plant sterols in the brain, good or bad? (2008) (2)
The role of bile in essential fatty acid absorption and metabolism (1998) (2)
Peroxisome proliferator-activated receptor delta activation increases intestinal cholesterol excretion in an ABCA1 independent manner (2003) (2)
The ABC-transporter genes Mdr1/Mdr1b, Mrp1, and Mrp3 are highly expressed in hepatic progenitor cells. (2001) (2)
BROMOSULFOPHTHALEIN (BSP) AND CLOSELY RELATED-COMPOUNDS INHIBIT CHOLESTEROL CRYSTALLIZATION IN BILE (1993) (2)
Increased fecal neutral sterol loss upon activation of the liver X receptor is independent of biliary cholesterol secretion in mice (2003) (2)
Increased hepatic cholesterol synthesis in mdr2 P-glycoprotein deficient mice with impaired biliary cholesterol and phospholipid secretion (1995) (2)
79 ALTERED BILE ACID METABOLISM IN BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS (1988) (2)
22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts (2015) (2)
BILIARY COPPER SECRETION IN RATS DURING EXPERIMENTAL COPPER OVERLOAD - THE ROLE OF HEPATOCYTIC LYSOSOMES REVISITED (1993) (2)
Does increased fatty acid oxidation enhance development of liver cirrhosis and progression to hepatocellular carcinoma in patients with glycogen storage disease type-III? (2007) (2)
Hepatic de novo synthesis of glucose-6-phosphate is not affected in PPAR α-deficient mice but is preferentially directed towards hepatic glycogen stores after a short-term fast (2017) (2)
TNF-alpha mediated up-regulation of the multidrug resistance gene mdr1b but not of mrp1 in rat hepatocytes is dependent on NF-kappa B activation (1999) (2)
Acute inhibition of hepatic β-oxidation in APOE*3Leiden mice does not affect hepatic VLDL secretion or insulin sensitivity Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.M400505-JLR200 (2005) (1)
ATP-DEPENDENT TAUROCHOLATE TRANSPORT IN CANALICULAR AND BASOLATERAL PLASMA-MEMBRANE VESICLES ISOLATED FROM HUMAN LIVER (1993) (1)
MS22 VOLUNTARY WHEEL RUNNING BENEFICIALLY AFFECTS CHOLESTEROL TURNOVER AND ATHEROSCLEROSIS IN HYPERCHOLESTEROLEMIC MICE (2010) (1)
CHAPTER 7 Increased fecal bile salt excretion is independent of the presence of dietary fat malabsorption in two mouse models for cystic fibrosis (1998) (1)
Heterogeneity in Simvastatin-Induced Cytotoxicity in AML Is Related to Differential Ras-Isoprenylation, Rather Than to Blockade of Cholesterol Synthesis. (2009) (1)
59 ATP‐DEPENDENT TAUROCHOLATE TRANSPORT IN HUMAN LIVER PLASMA MEMBRANE VESICLES (1992) (1)
University of Groningen Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1 Plosch, (2002) (1)
European Lipoprotein Club: report of the 26th ELC Annual Conference, Tutzing, 8-11 September 2003. (2005) (1)
Liver-gut axis controls the colonic mucus barrier via hepatic FXR (2021) (1)
Endogenous IL-10 Protects Against Hepatic Steatosis, but Does Not Improve Insulin Sensitivity During High Fat Feeding in Mice (2006) (1)
Abstract 1202: Hyperthyroidism Decreases Plasma HDL Cholesterol by Inhibition of Hepatic ABCA1 Expression (2006) (1)
Increased expression of the apical sodium-dependent bile salt transporter in liver and intestine of MDR2 P-glycoprotein-deficient mice. (2000) (1)
Pharmacomicrobiomics: a novel route towards personalized medicine? (2018) (1)
PHOTOAFFINITY-LABELING AND PARTIAL-PURIFICATION OF A TRANSPORTING GLUTATHIONE CONJUGATE-DEPENDENT ATPASE FROM CANALICULAR RAT-LIVER PLASMA-MEMBRANES (1992) (1)
TNF-α mediated up-regulation of the multidrug resistance gene mdrlb but not of mrpl in rat hepatocytes is dependent on NF-KB activation (1999) (1)
Scavenger Receptor BI Mediates Biliary Cholesterol Secretion Independent of Abcg5/g8 in Mice (2009) (1)
Advances in Molecular and Cell Biology (1994) (1)
Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70-/- mice with human-like bile acids. (2022) (1)
PHOTOAFFINITY-LABELING WITH 8-AZIDO[ALPHA-32P] ATP OF THE ATP-DEPENDENT GLUTATHIONE CONJUGATE TRANSPORTER IN CANALICULAR PLASMA-MEMBRANES FROM NORMAL WISTAR AND GY MUTANT RATS (1991) (1)
Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent from the Abcg5/Abcg8 transporter (2006) (1)
Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms. (2021) (1)
ON THE ROLE OF GLUTATHIONE IN BILIARY COPPER SECRETION IN RATS (1988) (1)
Differential effects of scavenger receptor BI (SRBI) deficiency on the arterial wall and the liver (2002) (1)
EFFICACY OF BILE-ACIDS TO INDUCE BILIARY LIPID SECRETION IS INFLUENCED BY BILE ACID-INDEPENDENT BILE-FLOW (BAIF) (1993) (1)
Omeprazole-Induced Dysbiosis Impacts Bile Acid Metabolism In Mice And Humans (2019) (1)
THE ROLE OF BILIARY CHOLESTEROL AND PHOSPHOLIPIDS IN THE REGULATION OF PLASMA-LIPID LEVELS - STUDIES IN MDR2 TRANSGENIC MICE (1994) (1)
The art of quantifying glucose metabolism. (2017) (1)
Gut microbial structural variations as determinants of human bile acid metabolism (2021) (1)
Liver-X-receptor agonist T0901317 suppresses endotoxin-induced expression of inflammatory genes in Kupffer cells in vitro (2005) (1)
The Wilson disease gene encodes a putative copper transport ATPase localized at the bile canalicular pole of the human hepatocyte. (1996) (1)
Increased atherosclerosis in a mouse model of glycogen storage disease type 1a (2022) (1)
DIETARY FISH OIL POTENTIATES BILE ACID-INDUCED CHOLESTEROL SECRETION IN RATS (1993) (1)
FOURTH INTERNATIONAL CONGRESS ON ESSENTIAL FATTY ACIDS AND EICOSANOIDS (1998) (1)
Bile salt sequestration induces the hepatic lipogenic pathway without altering bile salt pool size and transhepatic bile salt flux in mice (2008) (1)
BILE-SALT CONJUGATION IN THE RAT - INFLUENCE OF VARIATIONS IN HEPATIC BILE-SALT FLUX AND TAURINE ADMINISTRATION (1982) (1)
Strong induction of MDR2 P-glycoprotein expression in livers of simvastatin-treated rats. (1997) (1)
B002 Proprotein convertase sublitisin kexin type 9 null mice are protected from postprandial triglyceridemia (2009) (1)
Erratum to: Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid (vol 1438, pg 111, 1999) (1999) (1)
Relationship between liver size and liver function in mice (2019) (1)
BILIARY COPPER SECRETION IN RATS - THE ROLE OF LYSOSOMES AND GLUTATHIONE (1994) (1)
Hepatic steatosis and altered very low density lipoprotein (VLDL) formation in apolipoprotein (APO) E3-Leiden transgenic mice (2000) (1)
PROCEEDINGS OF THE FIRST EUROPEAN WORKSHOP ON GLUTATHIONE (1993) (1)
Role of the nuclear orphan receptor Rev-erb??; in the regulation of bile acid synthesis (2006) (1)
THE ENTEROHEPATIC CIRCULATION OF TRACE-ELEMENTS IN THE RAT (1982) (1)
Sustained activation of the mTOR nutrient sensing pathway associates with hepatic insulin resistance but not with steatosis per se in mice (2006) (1)
Hepatic lipid accumulation in transgenic mice carrying the apolipoprotein E3 Leiden gene (1997) (1)
Microbial Impact on Plasma Metabolites is Linked to the Cardiovascular Risk and Phenotypes (2018) (1)
Conversion of liposomal 5-fluoro-2'-deoxyuridine and its dipalmitoyl derivative to bile acid conjugates of alpha-fluoro-beta-alanine and their excretion into rat bile. (1993) (1)
O.55 The contribution of newly formed cholesterol to bile salt synthesis in the rat determined by mass isotopomer distribution analysis (MIDA) (1997) (1)
HEPATIC CATABOLISM OF CHOLESTEROL (1986) (0)
Bile duct proliferation and biliary fibrosis associated with altered bile composition in a mouse model of erythropoetic protoporphyria. (1998) (0)
Evidence for ATP-binding-cassette transporter g5 (ABCG5)-independent hepatobiliary cholesterol secretion in mice. (2004) (0)
Cholesteryl ester transfer protein does not alter cholesterol and bile salt excretion in transgenic mice (2005) (0)
Higher glomerular filtration rate predicts lower high density lipoprotein cholesterol and apolipoprotein A-I concentrations in subjects without compromised kidney function (2011) (0)
Bile acids and metabolic control: bile acid-sensing by FXR (2008) (0)
PPAR-ALPHA deficiency aggravates diabetes in ob/ob mice (2005) (0)
IMPAIRMENT OF BILE FLOW IN LIVERS AFFECTED BY STEATOSIS OR STEATOHEPATITIS (2008) (0)
Gallistono formation in patients with hypertriglyceridemia: Altered bile composition, gallbladder dysmotility or both? (2001) (0)
Elevated copper induces relocation of the copper transporter ATP7B from the Trans-Golgi network to the apical membrane in HepG2 cells (1999) (0)
KEYNOTE: WHAT COULD COME FROM UNDERSTANDING THE BIOLOGY OF AGING? (2017) (0)
2 DIFFERENT PATHWAYS FOR BILIARY COPPER EXCRETION IN THE RAT (1989) (0)
Cholestatic bile salt concentrations do not affect proliferation or differentiation of intestinal epithelial cells in vitro (2007) (0)
Glycogen storage disease type 1a patients with severe hyperlipidemia are protected from premature onset of atherosclerosis by resistance of lipoproteins to oxidative modification (1999) (0)
Differential effects of farnesoid X receptor-deficiency on hepatic and intestinal triglyceride-rich lipoprotein formation in mice (2004) (0)
Severe sitosterolemia but unaffected biliary cholesterol content in ATP-binding cassette transporter ABCG5-null mice (2003) (0)
longitudinal studies in mice A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in (2013) (0)
University of Groningen Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice Boesjes, (2014) (0)
In memoriam: Marten Hofker (1956-2016). (2016) (0)
Evidence-based management of Lipid disorders (2010) (0)
Differential effects of 24(S)‐hydroxycholesterol in astrocytes and on the expression of apolipoprotein E and apolipoprotein E‐mediated cholesterol efflux. (2006) (0)
33 DEFECTIVE BILE SECRETION OF BILE ACID GLUCURONIDES IN RATS WITH HEREDITARY CONJUGATED HYPERBILIRUBINEMIA: IMPLICATIONS FOR THE MECHANISM OF CHOLESTAIS (1988) (0)
Bile formation and ABC-transporter expression in rats with streptozotocin-induced diabetes. (2000) (0)
CHOLESTASIS INDUCED BY SULFATED GLYCOLITHOCHOLIC ACID IN THE RAT - THE PROTECTING EFFECT OF ENDOGENOUS BILE-ACIDS (1984) (0)
Hepatotoxic actions of dietary cholesterol in MDR2 P-glycoprotein-deficient mice. (1997) (0)
Dietary fish oil potentiates bile acid-induced cholesterol secretion into bile in rats 1 (2002) (0)
Differential effects of pharmacological LXR activation on peripheral and hepatic insulin sensitivity in lean and ob/ob mice. (2005) (0)
Gender-Specific Differences At Both Extreme Ends Of The Ldl Cholesterol Distribution Curve (2019) (0)
SULFATED LITHOCHOLIC ACID CONJUGATES AND CHOLESTASIS: CLINICAL IMPLICATIONS AND PROTECTING FACTORS (1985) (0)
Abstract 3477: Liver X Receptor-Alpha is a Regulator of the Renal and Cardiac Renin-Angiotensin System (2008) (0)
The biliary phosphatidylcholine acyl chain specificity is determined independently from the biosynthetic origin of the phosphatidylcholine headgroup (1998) (0)
Emerging Roles of Gut Microbial Modulation of Bile Acid Composition in the Etiology of Cardiovascular Diseases (2023) (0)
The intestinal FXR-mediated Fgf-115 pathway contributes to the diurnal control of hepatic bile acid synthesis and bile formation in chow fed mice but its contribution is overruled during bile acid feeding and bile acid sequestration (2009) (0)
European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006. (2007) (0)
A maternal low protein diet programs glucose and fatty acid metabolism differentially in adult male and female mouse offspring (2011) (0)
The search for proteins involved in transport of cholesterol and related sterols (2004) (0)
Enterohepatic circulation and cholestasis (1987) (0)
University of Groningen Secretory phospholipase A ( 2 ) increases SRB 1-mediated selective uptake from HDL but not biliary cholesterol secretion (2008) (0)
Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems (2009) (0)
Thyroid hormone induces biliary cholesterol secretion mediated by the ATP-binding cassette G5 and G8 proteins (2010) (0)
not due to impaired bile formation Fat malabsorption in essential fatty acid-deficient mice is (2016) (0)
circulation of bile salts in health and disease (2017) (0)
W15-P-004 PPAR-alpha deficiency aggravates diabetes in OB/OB mice (2005) (0)
Glutathione is required for the induced expression of iNOS in rat hepatocytes in vivo and in vitro (1998) (0)
Processing of cholesteryl ester from low density lipoproteins in the rat: hepatic metabolism and biliary excretion after uptake by different hepatic cells. (1988) (0)
In vivo production of VLDL-apo-B and VLDL-triglycerides are not affected by the LDL receptor (2000) (0)
CHAPTER 6 Essential fatty acid deficiency in mice : milder fat malabsorption and a more hydrophobic bile salt composition (2007) (0)
Treatment of essential fatty acid deficiency in a murine model of cholestasis (2003) (0)
Cyclosporin A-induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation (2004) (0)
We-W37:1 The metabolic syndrome: It's in the movement of fatty acids, as learnt from studies in transgenic mice (2006) (0)
Nuclear receptor FXR controls sensitivity to the insulin (2006) (0)
Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis (2023) (0)
UNCOUPLING OF BILIARY LIP ID SECRETION FROM BILE ACID SECRETION BY ORGANIC ANIONS, DUE TO INTRACANALICULAR INTERACTION WITH BILE ACIDS (1989) (0)
Characterization of intestinal fat malabsorption : In vivo differentiation between lipolysis and solubilization. (1998) (0)
The acyl chain specificity of biliary phosphatidylcholine is independent from its biosynthetic origin (1998) (0)
FXR-deficient mice are resistant to obesity induced by fad diets (2007) (0)
Metabolic Syndrome X (1999) (0)
BILE-ACID METABOLISM IN MAN - A NEW, EASY METHOD OF DETERMINING DUODENAL BILE-ACIDS (1986) (0)
Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome (2018) (0)
Kupffer cell depletion preserves ntcp gene expression in endotoxemic rats. (2002) (0)
INHIBITION OF VERY-LOW-DENSITY LIPOPROTEIN (VLDL) SECRETION BY CULTURED RAT AND HUMAN HEPATOCYTES IN THE PRESENCE OF PHYSIOLOGICAL BILE-ACID CONCENTRATIONS (1994) (0)
Bile acids and cholestasis. (2013) (0)
74 A SIMPLE METHOD FOR THE DETERMINATION OF BILE ACID POOL COMPOSITION IN MAN (1986) (0)
Intestinal expression of cholesterol transporter genes and chylomicron formation are not affected by dietary phytosterols and stanols in rodents (2006) (0)
Retinoids Decrease Plasma HDL Cholesterol Levels by Increasing Cholesteryl Ester Transfer Protein Expression and Activity in Transgenic Mice (2009) (0)
Response to Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH (2022) (0)
Colesevelam treatment increases hydrophilicity of the bile acid pool and reduces FGF19 signaling without altering total bile acid pool size in healthy and type 2 diabetic subjects (2010) (0)
The canalicular bile salt export pump BSEP is not expressed in livers of PFIC-2 patients (1999) (0)
Aramchol induces cholesterol and phospholipid efflux from cultured cells in an ABCA1 dependent way (2003) (0)
Impaired postprandial chylomicron formation but quantitatively unaffected fat absorption in multidrug resistance gene-2 P-glycoprotein-deficient mice (1999) (0)
Transfer of dietary plant sterols across the blood-brain barrier (2006) (0)
Rapid recovery of bile salt secretion is associated with transient bile duct injury after human liver transplantation (2004) (0)
141 PATHOGENESIS OF EREDITARY TYROSINEMIA TYPE I: METABOLID DISORDERS IN CULTURED HEPATOCYTES FROM TRANSPLANATION PATIENTS (1991) (0)
Chapter 5 Induction of Mdr 1 b expression by tumor necrosis factor-α in rat liver cells is independent of p 53 but requires NF-κ B signaling (2002) (0)
European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007. (2008) (0)
W40 FXR-DEFICIENCY IMPROVES GLUCOSE AND ENERGY HOMEOSTASIS IN GENETIC OBESITY (2010) (0)
Abstract 5518: Mice Deficient for Proprotein Convertase Subtilisin Kexin Type 9 are Protected Against Postprandial Lipemia (2008) (0)
Elevated plasma cholesterol concentrations comprise a major risk factor for development of atherosclerosis and cardiovascular disease remaining the leading cause of morbidity and mortality (2004) (0)
Impaired linoleic acid (LA) status in bile - Diverted rats is not due to decreased LA absorption. (1998) (0)
Down-regulation of the phosphatidylcholine translocator MDR2 by insulin in cultured rat hepatocytes. (2002) (0)
Tu-P8:318 Modulation of plasma HDL by intestine specific activation of the liver X receptor (2006) (0)
Reply to: “Impaired expression of multidrug resistance–associated protein 2 and liver damage in erythropoietic protoporphyria” (2016) (0)
Perturbed lysosomal architecture and localization in liver-specific WASH-deficient mice does not affect hepatic cholesterol and bile acid metabolism (2019) (0)
Cell Metabolism, deadline February 7th, 2020 Title Microbiome modulation of host’s adaptive immunity through bile acid modification (2021) (0)
Mutations in the gene encoding the bile salt export pump are responsible for progressive familial intrahepatic cholestasis type 2 (1999) (0)
EFFECTS OF PARTIAL COLONIC RESECTIONS ON INTESTINAL BILE-ACID METABOLISM (1993) (0)
Chapter 5 Type 1 Diabetes Mellitus Decreases in vivo Macrophage-to-Feces Reverse Cholesterol Transport Despite Increased Biliary Sterol Secretion in Mice (2018) (0)
Impaired adaptive response to fasting in FXR-deficient mice (2005) (0)
Altered hepatic cholesterol metabolism in peroxisome Proliferator-activated receptor alpha-deficient mice (1999) (0)
Fish oil does not prevent high fat diet-induced peripheral insulin resistance in mice (2007) (0)
Lipid metabolism is regulated by the liver X receptor in the fetal mouse liver (2006) (0)
49 FARNESOID X RECEPTOR ACTIVATION INDUCES CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION IN HUMANS AND TRANSGENIC MICE (2011) (0)
Induction of lipogenesis by a high-fat diet does not stimulate hepatic VLDL-triglyceride production in mice (2008) (0)
Autoantibodies to apolipoprotein A-I as independent predictors of cardiovascular mortality in renal transplant recipients (2018) (0)
Carbohydrate digestion and absorption in a rat model of cholestasis (2007) (0)
Induction of hepatic lipogenic gene expression upon pharmacological inhibition of glucose-6-phosphate translocase is independent of liver X receptor alpha Chapter 7 (2006) (0)
CHOLESTASIS AND THE DIFFERENTIAL INTERACTIONS OF SULFATED GLYCO AND TAUROLITHOCHOLATE WITH SOLUBLE CALCIUM AND INSOLUBLE CALCIUM-PHOSPHATE (1987) (0)
SHORT-TERM EFFECTS OF DIETARY CALCIUM SUPPLEMENTATION ON FECAL EXCRETION OF MINERALS AND BILE-ACIDS (1988) (0)
Unexpected consequences of sitosterolemia on platelet formation. (2006) (0)
Chapter 3 Dietary fat-induced hepatic insulin resistance with regard to VLDL production in rats (2002) (0)
The nuclear receptor FXR regulates adipocyte differentiation and function by interfering with the Wnt/beta-catenin and by inducing path fignalisation PPAR. (2010) (0)
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases (2023) (0)
The role of the intestine in reverse cholesterol transport. (2005) (0)
A Human-Like Composition Of The Circulating Bile Acid Pool Impacts On Plasma Ldl Cholesterol In Mice (2019) (0)
Regulation of hepatocyte abc-transporters during liver regeneration. (1996) (0)
TMAO and its precursors in relation to host genetics, gut microbial composition, diet, and clinical outcomes: Meta-analysis of 5 prospective population-based cohorts (2022) (0)
HETEROGENEITY OF RAT HEPATOCYTES IN METABOLISM AND BILIARY TRANSPORT OF CHOLIC-ACID AND GLYCOCHOLIC ACID (1988) (0)
In Vivo Treatment of AML Patients with High-Dose Simvastatin Inhibits Geranylgeranylation In AML Cells (2010) (0)
[Liver diseases in infants. Metabolism and transport of bilirubin and bile acids]. (1993) (0)
Cholestasis induced by precipitation in the biliary tree. Mechanism studied with indocyanine green (1991) (0)
Regulation of intestinal fat absorption as a novel therapeutic strategy to enhance excretion of toxic hydrophobic compounds from the body (2000) (0)
BILE-ACID METABOLISM IN MAN - DETERMINATION OF BILE-ACID POOL SIZE BY THE STABLE ISOTOPE-DILUTION TECHNIQUE (1986) (0)
DIFFERENTIAL HEPATIC PROCESSING AND BILIARY-SECRETION OF LIPOSOMAL PHOSPHOLIPIDS IN THE RAT (1988) (0)
Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome (2018) (0)
Increased expression of mdr2 P-glycoprotein and biliary secretion of phospholipids in streptozotocin-induced diabetic rats (1999) (0)
Hepatic gluconeogenic flux is not affected in PPAR alpha- deficient mice, but is preferentially directed towards glycogen stores after a short-term fast. (2002) (0)
ODEVIXIBAT TREATMENT INDUCES BILIARY BILE ACID SECRETION IN RESPONSIVE PATIENTS WITH BILE SALT EXPORT PUMP DEFICIENCY (PFIC2). (2023) (0)
Cholestatic conditions and intestinal cell proliferation and differentiation (2007) (0)
ROLE OF APOLIPOPROTEIN-E (APOE) IN INTRACELLULAR LIPID-METABOLISM AND VERY-LOW-DENSITY LIPOPROTEIN (VLDL) SECRETION BY MOUSE HEPATOCYTES (1995) (0)
Stimulation of fecal fat excretion and the disposal of protoporphyrin in a murine model for erythropoietic protoporphyria. (2007) (0)
Involvement of apolipoprotein E in triacylglycerol incorporation into Very Low Density Lipoprotein particles (2001) (0)
Regulation of hepatobiliary transport and bile formation: lessons from knockout mice (2004) (0)
How can we deal with inborn errors in cholesterol and bile acid biosynthesis (2010) (0)
CHOLESTASIS AND THE INTERACTIONS OF SULFATED GLYCO-LITHOCHOLATE AND TAUROLITHOCHOLATE WITH CALCIUM (1988) (0)
University of Groningen Expression and regulation of ABC transporter genes during liver regeneration (2017) (0)
Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome (2018) (0)
Effects of pharmacological FXR activation on the enterohepatic circulation of bile salts in rats (2004) (0)
Th-P15:15 Characterization of the direct trans-intestinal cholesterol excretion pathway (2006) (0)
DNA methylation of the Liver X‐Receptor (LXR) gene promoter in the fetal mouse liver (2011) (0)
3P-0737 Bile acid metabolism in hypertriglyceridemic patients. Effects of body mass index and triglyceride-lowering therapy by bezafibrate and fish-oil (2003) (0)
The fed to fasting transition differentially affects PEPCK protein expression in pericentral and periportal murine hepatocytes (2011) (0)
CHAPTER 4 The 13 C-palmitic acid test with plasma sampling detects fat malabsorption in bile-diverted rats (1998) (0)
What Is The Origin Of Severe Hypercholesterolemia In A Large Cohort Of Emiratis With A High Prevalance Of Type 2 Diabetes (2019) (0)
TRANSCRIPTIONAL REGULATION OF THE RAT PHOSPHOLIPID TRANSLOCASE MDR 2 GENE EXPRESSION BY CHOLESTEROL SYNTHESIS INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEINS (2000) (0)
Farnesoid X receptor (FXR) regulates peripheral insulin sensitivity (2005) (0)
BILE ACIDS: FROM GENOMICS TO DISEASE AND THERAPY (2003) (0)
ACUTE SUPPRESSION OF VERY-LOW-DENSITY LIPOPROTEIN SECRETION BY BILE-ACIDS - POTENTIAL ROLE IN THE REGULATION OF POSTPRANDIAL LIPID-METABOLISM (1995) (0)
Effects of fish-oil vs bezafibrate on lipid parameters and determinants of cholelithiasis in hypertriglyceridemia (2001) (0)
10 DIFFERENCES IN HEPATIC PROCESSING OF DIETARY AND I.V. ADMINISTERED COPPER IN NORMAL WISTAR (NW) AND MUTANT GRONINGEN YELLOW (GY) RATS (1992) (0)
Abstract 1099: Reduced Fecal Sterol Excretion in Subjects with Low HDL Cholesterol Levels (2007) (0)
ABCA1/SR-BI DOUBLE DEFICIENT MICE DEMONSTRATE THE INDEPENDENT ROLES FOR ABCA1 AND SR-BI IN REVERSE CHOLESTEROL TRANSPORT (2008) (0)
471 The molecular mechanism of biliary cholesterol secretion (2003) (0)
P62 Total, primary, and secondary serum bile acid changes and pruritus improvement during odevixibat treatment in patients with progressive familial intrahepatic cholestasis (2022) (0)
Chronic prednisolone treatment leads to dyslipidemia in mice carrying a dimerization-defective glucocorticoid receptor (2011) (0)
ATP-DEPENDENT COPPER TRANSPORT IN RAT-LIVER PLASMA-MEMBRANES (1994) (0)
The effects of transhepatic bile salt flux on hepatic production of very low density lipoprotein triglyceride in vivo in rats and mice. (2001) (0)
Activation of the liver X-receptor (LXR) leads to increased cholesterol excretion into bile and feces independent of Abca1 in mice. (2002) (0)
ATP-dependent copper transport in human liver (cCOP). (1996) (0)
Combining Simvastatinwith the Farnesyltransferase Inhibitor Tipifarnib Results in an Enhanced Cytotoxic Effect in a Subset of Primary CD 34 + AcuteMyeloid Leukemia Samples (2009) (0)
The induction of inducible Nitric Oxide Synthase (iNOS) in endotoxemic hepatocytes is dependent on the intracellular redox status (1999) (0)
Alterations in bile formation and the expression of hepatobiliary transportes in human orthotopic liver transplantation (2002) (0)
CHAPTER 5 Abcg 5 / Abcg 8-independent pathways contribute to hepatobiliary cholesterol secretion in mice (2018) (0)
Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study (2022) (0)
Inhibition of glucose-6-phosphatase activity in rats leads to increased lipogenesis and development of fatty liver without affecting hepatic VLDL-triglyceride production (1999) (0)
Apolipoprotein e-dependent and -independent regulation of very-low-density lipoprotein-triglyceride secretion in mice (1999) (0)
Reply (2020) (0)
Mdr1a/b nor Mdr2 P-glycoprotein is essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria. (2001) (0)
Acute inhibition of carnitine palmitoyl transferase I in vivo does not increase hepatic VLDL secretion (2004) (0)
The Liver X Receptor (LXR) is functionally active in the fetal mouse liver (2007) (0)
Genome-wide transcriptome analysis of livers from obese subjects reveals lncRNAs associated with progression of fatty liver to nonalcoholic steatohepatitis (2019) (0)
Regulation of sterol transport in mouse enterocytes by the Liver-X-Receptor LXR (2004) (0)
LACK OF APOLIPOPROTEIN-E DOES NOT AFFECT BILE-ACID METABOLISM AND BILE SECRETION OF CHOLESTEROL IN CHOW-FED MICE (1994) (0)
RELATIONSHIP BETWEEN HEPATOBILIARY TRANSPORT AND CHOLESTATIC PROPERTIES OF LITHOCHOLIC ACID CONJUGATES IN RATS (1994) (0)
Macrophage 12/15-Lipoxygenase Deficiency Increases the Development of Adipose Tissue Inflammation and Insulin Resistance (2010) (0)
INHIBITION OF BILE-ACID FORMATION IN THE RAT BY MEVINOLIN, A POTENT BLOCKER OF CHOLESTEROL-SYNTHESIS (1987) (0)
Prednisolone-treatment increases fasting glucose and insulin levels, but does not affect hepatic and peripheral insulin sensetivity (2008) (0)
Chapter 2 High-fat feeding in rats abolishes the ability of insulin to suppress de novo glucose-6-phosphate synthesis (2002) (0)
P61 Total, primary, and secondary serum bile acid concentrations in patients with progressive familial intrahepatic cholestasis with serum bile acid response or not with odevixibat treatment: assessing the contribution of ursodeoxycholic acid concentration (2022) (0)
Chapter 4 Cyclosporin A-induced reduction of bile salt synthesis associated with increased plasma lipids in children after liver transplantation (2004) (0)
Total, primary, and secondary serum bile acid changes and pruritus improvement during odevixibat treatment in patients with progressive familial intrahepatic cholestasis (2022) (0)
Elevated copper induces translocation of the Wilson disease protein from Golgi to the apical membrane in HepG2 hepatoma cells (1998) (0)
University of Groningen Metabolic responses to long-term pharmacological inhibition of CB 1-receptor activity in mice in relation to dietary fat composition (2017) (0)
Reply to Letter to the Editor HEP-20-0593. (2020) (0)
Farnesoid X Receptor alters adipose tissue architecture in mice and limits storage capacity leading to metabolic derangements (2019) (0)
Secretory phospholipase A2 expression in transgenic mice results in increased hepatic selective HDL cholesteryl ester uptake without influencing biliary and fecal sterol excretion (2005) (0)
Liver X Receptor-Alpha is a Regulator of the Renal and Cardiac Renin-Angiotensin System (2008) (0)
BILE ACIDS IN GASTROENTEROLOGY (1995) (0)
Impaired cholate synthesis without change in cholate pool size in cyclosporin A-treated rats, associated with induction of the ileal. sodium-dependent bile salt transporter (2000) (0)
Induction of Mdr2 expression as a component of the peroxisome proliferator-activated receptor alpha (PPAR alpha)-induced fasting response in the mouse. (2001) (0)
COLONIC EPITHELIAL-CELL PROLIFERATION IN ACROMEGALY - RELATION WITH GROWTH-HORMONE, INSULIN-LIKE GROWTH-FACTOR ONE AND INTESTINAL BILE-ACIDS (1994) (0)
The Enterohepatic Circulation of Sulfated and Nonsulfated Bile Acids (1987) (0)
CHAPTER 4 Cholestatic conditions and intestinal cell proliferation and differentiation (2007) (0)
Pharmacological inhibition of ACC activity by Soraphen reverses high fat-induced obesity and insulin resistance (2009) (0)
Improving chemotherapy efficacy in acute myeloid leukemia patients by modulation of dysfunctional cholesterol metabolism (2006) (0)
Liver, gastrointestinal and metabolic diseases (2003) (0)
University of Groningen Regulatory enzymes of mitochondrial B-oxidation as targets for treatment of the metabolic syndrome (2017) (0)
Nutrition and Disease Fish Oil Increases Bile Acid Synthesis in Male Patients with Hypertriglyceridemia 1 (2006) (0)
Lipoprotein-X formation in mouse models of Erythropoietic Protoporphyria (2000) (0)
Circadian rhythms in hepatic Abcg5 and Abcg8 expression and biliary cholesterol secretion in mice (2018) (0)
THE ROLE OF INCREASED BILIARY PRESSURE AND TOXIC BILE COMPONENTS IN THE PATHOGENESIS OF CHOLESTATIC LIVER FIBROSIS (1991) (0)
Fetal lipid metabolism is regulated by the Liver X Receptor (LXR) in mice (2009) (0)
INCREASED INTESTINAL-ABSORPTION AND URINARY DISPOSITION OF COPPER IN MUTANT GY WISTAR RATS AFTER CHRONIC CU-LOADING (1994) (0)
472 Diosgenin-induced biliary cholesterol hypersecretion depends on the presence of ABCG8 (2003) (0)
Scavenger receptor BI mediates biliary cholesterol secretion independent of ATB binding cassette transporters G5/G8 (2010) (0)
Chapter 2 12 / 15-Lipoxygenase Deficiency Promotes the Development of Adipose Tissue Inflammation and Insulin Resistance (2018) (0)
W15-IS-002 Role of farnesoid X receptor (FXR) in control of plasma lipid levels (2005) (0)
FXR activation normalizes dyslipidemia and alleviates obesity in western-type diet–fed APOE*3-Leiden.CETP transgenic mice (2018) (0)
Dominant drivers of the human plasma metabolome (2021) (0)
ABCA1xSR-BI double knockout mice show the independent functions of ABCA1 and SR-BI in reverse cholesterol transport (2005) (0)
HUMAN HEPATOCYTES ARE LESS SUSCEPTIBLE TO PROPIONATE-INDUCED INHIBITION OF LIPID-SYNTHESIS THAN RAT HEPATOCYTES (1993) (0)
The mechanism of organic anion-induced uncoupling of biliary lipid from bile acid secretion in the rat (1989) (0)
Mouse models for human disorders of mitochondrial fatty acid oxidation: studies on glucose metabolism (2007) (0)
Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms (2020) (0)
BILE-ACID POOL COMPOSITION IN HUMAN - INFLUENCE OF DIETARY FACTORS (1988) (0)
UvA-DARE ( Digital Academic Repository ) Novel insights in cholesterol excretion (2009) (0)
Sitosterolemia in ABCG5-Null mice is aggrevated upon activation of the liver X-receptor (2003) (0)
Effect of cotreatment with statins and farnesyltranferase inhibitors on acute myeloid leukemia cells (2008) (0)
Increased hepatobiliary cholesterol transport by activation of the liver X-receptor LXR is independent of ABCA1 in mice (2002) (0)
INTESTINAL ABSORPTION OF SULFATED LITHOCHOLIC ACID CONJUGATES: EFFECT OF CALCIUM (1985) (0)
Activation of the liver x receptor (LXR) in utero does not affect lipid metabolism in mouse offspring upon high fat dietary challenge (2008) (0)
Activation of liver X receptor attenuates activation of the renal and cardiac renin-angiotensin system (2009) (0)
PS-038-A humanized bile acid pool induced by somatic CRISPR/Cas9-mediated deletion of Cyp2c70 modulates effects of pharmacological FXR activation in mice (2019) (0)
Altering activity of the Farnesoid-X receptor (FXR) reduces atherogenicity of the plasma lipid profile (2003) (0)
THE ROLE OF GLUTATHIONE IN BILE SECRETION OF COPPER AND ZINC IN RATS (1993) (0)
Elevated plasma bile salt levels without cholestasis in mdr2 P-glycoprotein-deficient mice due to impaired Na+-taurocholate transporting protein (Ntcp) function (1999) (0)
Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice (2023) (0)
Hepatic glucose-6-phosphate metabolism is perturbed in LXR-alpha-null mice (2008) (0)
Cyclosporin A inhibits bile salt synthesis rate and increases plasma triglycerides after liver transplantation in children (2003) (0)
Acids in Adipose Tissue Mediated Lipolysis and Decreases Uptake of Fatty − Ritonavir Impairs Lipoprotein Lipase (2005) (0)
Figure 1, [The liver as a central organ in lipid metabolism.]. (2013) (0)
Zonal distribution of apolipoprotein B messenger RNA in rodent liver (2001) (0)
Transmission of gut bacteria and viruses from mothers to infants (2021) (0)
Pharmacological blockade of the ACC system prevents obesity but only marginally improves insulin sensitivity in mice fed a high fat diet (2007) (0)
CHAPTER 7 Activation of the Liver X Receptor stimulates direct intestinal secretion of plasma cholesterol (2018) (0)
PREFERENTIAL USE OF LIPOSOMAL-CHOLESTEROL FOR THE FORMATION OF MURICHOLIC ACID IN THE RAT (1985) (0)
Detection of intestinal fat malabsorption due to impaired lipolysis by the 13C‐mixed triglyceride breath test in rats (1998) (0)
Abstract 424: Transintestinal Cholesterol Excretion Can Drive Massive Cholesterol Elimination in Mice (2016) (0)
Impaired cholic acid synthesis without change in cholic acid pool size in cyclosporin A-treated rats, associated with induction of the ileal apical sodium-dependent bile acid transporter (2000) (0)
Assessment of triple bile acid kinetics in humans applying single stable isotope administration and dual blood sampling (2010) (0)
P1-12 Activation of the Liver X Receptor in utero does not affect lipid metabolism in MOUSE offspring upon high fat dietary challenge (2007) (0)
The fed to fasting transition differentially affects phosphoenol pyruvate carboxykinase protein but not gene expression in pericentral and periportal murine hepatocytes (2010) (0)
Adenosine triphosphate-dependent copper transport in human liver plasma membranes (1995) (0)
Computational analysis of carbohydrate metabolism (2010) (0)
Dietary plant sterol and plant stanol supplementation increases fecal cholesterol excretion and prevents hepatic triglyceride accumulation in mice on cholesterol diet without influencing intestinal gene expression (2005) (0)
Constitutive androstane receptor negatively regulates human apolipoprotein A-1 expression (2005) (0)
Hepatic synthesis and hepatobiliary cholesterol transport are not effected in ABCA1-deficient mice (2001) (0)
CHAPTER 2 Detection of intestinal fat malabsorption due to impaired lipolysis by the 13 C-mixed triglyceride breath test in rats (1998) (0)
MDR2 GENE EXPRESSION BY CHOLESTEROL SYNTHESIS INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEINS (2000) (0)

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